Vegetable oil composition, double essence and preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a vegetable oil composition as well as a preparation method and application thereof. The vegetable oil composition provided by the invention comprises double purple oil, jasmine flower oil and pelargonium graveolens flower oil, the mass ratio of the double purple oil to the jasmine flower oil to the pelargonium roseum flower oil is (0.08-0.5): (0.01-0.5): (0.01-0.5). Furthermore, the invention provides the double essence as well as a preparation method and application thereof. The vegetable oil composition provided by the invention can play roles in synergistically inhibiting the activity of hyaluronidase and reducing the decomposition of hyaluronic acid, so that the vegetable oil composition has the functions of maintaining skin moisture and elasticity and protecting and repairing a skin barrier.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics. More particularly, it relates to a plant oil composition, a dual essence and a preparation method and application thereof. BACKGROUND

[0002] Skin is the largest organ of the human body and the first line of defense against external stimuli. It is like a "brick-mud" structure of the Great Wall: keratinocytes are "bricks", and intercellular lipids are "mud". When this Great Wall is intact, water is tightly locked, and elastic fibers and collagen remain full in a moist environment, and the skin appears soft, tight, and shiny. The stratum corneum is like an "intelligent sponge" with a water content of less than 10%. When it is dry and cracked, collagen and elastic fibers collapse. When water is sufficient, collagen fibers are like inflated springs, maintaining fullness and resilience. Hyaluronic acid has the triple functions of "moisturizing-locking-repairing", which can maintain skin moisture and elasticity, and protect and repair skin barrier function. By inhibiting the activity of hyaluronidase, the degradation of hyaluronic acid can be effectively reduced, thereby reducing the release of histamine and inflammatory factors, and playing a certain repair role of soothing and anti-sensitivity.

[0003] Jasmine flower essential oil contains jasmonate and polyphenols, which can absorb water from the air. The polyphenol molecular structure contains multiple phenolic hydroxyl groups, which can inhibit the activity of hyaluronidase and reduce the decomposition of hyaluronic acid, and can achieve deep moisturizing, soothing and repairing effects. How to provide more skin care products with excellent soothing and repairing effects based on jasmine oil is a technical problem that needs to be solved by those skilled in the art. SUMMARY

[0004] The technical problem to be solved by the present application is to overcome the defects and deficiencies of the prior art and provide a plant oil composition.

[0005] A second object of the present application is to provide a preparation method of the plant oil composition.

[0006] A third object of the present application is to provide an application of the plant oil composition in preparing a cosmetic for inhibiting the activity of hyaluronidase or soothing and repairing the skin.

[0007] A fourth object of the present application is to provide a dual essence.

[0008] A fifth object of the present application is to provide a preparation method of the dual essence.

[0009] A sixth object of the present application is to provide an application of the dual essence in preparing a cosmetic for inhibiting the activity of hyaluronidase or soothing and repairing the skin.

[0010] The above objects of the present application are achieved by the following technical solutions:

[0011] A plant oil composition comprising double purple oil, jasmine flower oil, and geranium oil; the mass ratio of the double purple oil, jasmine flower oil, and geranium oil being 0.08-0.5:0.01-0.5:0.01-0.5.

[0012] The present application provides a plant oil composition comprising double purple oil, jasmine flower oil, and geranium oil. In the present application, the jasmine flower oil contains jasmonate and polyphenols, which can inhibit the activity of hyaluronidase and reduce the decomposition of hyaluronic acid. The geranium oil and double purple oil in the present application contain flavonoids and other substances that can inhibit the activity of hyaluronidase, promote skin cell water absorption and water retention, improve dry and rough problems, and make the skin soft and smooth. The inventors have found through research that the above-mentioned three components can synergistically inhibit the activity of hyaluronidase and reduce the decomposition of hyaluronic acid, thereby maintaining skin moisture and elasticity, protecting and repairing the skin barrier, and soothing and repairing the skin.

[0013] Preferably, the mass ratio of the double purple oil, jasmine flower oil, and geranium oil is 0.1-0.3:0.1-0.3:0.1-0.3. Further preferably, the mass ratio of the double purple oil, jasmine flower oil, and geranium oil is 0.1:0.1:0.1.

[0014] Further, the present application claims a preparation method of a plant oil composition, which uniformly mixes double purple oil, jasmine flower oil, and geranium oil to obtain the plant oil composition.

[0015] Further, the present application claims the use of the plant oil composition in the preparation of a cosmetic for inhibiting the activity of hyaluronidase or soothing and repairing the skin.

[0016] Further, the present application claims a double essence comprising an aqueous phase and an oil phase; the oil phase comprising the above-mentioned plant oil composition.

[0017] In some embodiments, the double essence comprises an aqueous phase and an oil phase in a mass ratio of 65-75:25-35.

[0018] The water phase comprises, in parts by weight: 60-65 parts of Schizochytrium ferment filtrate, 4-6 parts of birch juice, 0.06-0.1 part of a metal chelating agent, 0.8-3 parts of a thickening agent, 0.02-0.08 part of sodium hyaluronate, 6-15 parts of a humectant, 0.03-0.07 part of an antioxidant, 0.01-0.05 part of 4-butylresorcinol, 0.1-0.3 part of acetylated chitosamine, 0.17-0.3 part of ergothioneine, 0.17-0.3 part of Centella asiatica extract, 0.2-0.6 part of a preservative, and 0.12-0.16 part of a pH adjuster;

[0019] The oil phase comprises, in parts by weight: 13-14 parts of C15-19 alkane, 0.1-0.2 part of ascorbic acid tetraisopalmitate, 3-10 parts of squalane, 0.3-0.7 part of tocopheryl acetate, 0.8-1.2 part of argan oil, 0.08-0.5 part of bisamyl oil, 0.01-0.1 part of orange oil, 0.01-0.5 part of jasmine flower oil, and 0.01-0.5 part of geranium oil.

[0020] The present application provides a dual essence based on a plant oil composition. The dual essence has an oil phase in the upper layer and a water phase in the lower layer, and is stable, has moderate oil-water layering, and a clear interface. The dual essence of the present application uses a water-free formula and replaces water with Schizochytrium ferment filtrate as a solvent, which is rich in various amino acids, vitamins, minerals and other bioactive substances, and can provide more nutrients and stronger effects for the skin, penetrate the skin bottom layer, provide long-lasting and deep nourishment and moisturization, and effectively improve the dry and water-deficient condition of the skin. In addition, the dual essence provided by the present application does not add emulsifiers, fragrances and other ingredients, and does not cause additional burden to the skin, and is more friendly to sensitive skin.

[0021] The dual essence provided by the present application is rich in various functional ingredients, and the ingredients are mutually adjusted, so that it can prevent damage to the skin barrier, promote the repair process of the damaged skin barrier, and has good anti-allergic effect on sensitive skin with abnormal skin barrier function; at the same time, it has good whitening, anti-wrinkle, moisturizing and repair effects.

[0022] Preferably, the water phase comprises, in parts by weight: Schizochytrium ferment filtrate 62-63 parts, birch juice 5-5.5 parts, metal chelator 0.06-0.1 part, thickening agent 0.8-1.5 parts, sodium hyaluronate 0.04-0.06 part, humectant 6-15 parts, antioxidant 0.04-0.06 part, 4-butylresorcinol 0.01-0.03 part, acetylchitose 0.1-0.3 part, ergothioneine 0.17-0.25 part, centella asiatica extract 0.17-0.25 part, preservative 0.3-0.5 part, pH adjuster 0.12-0.16 part; the oil phase comprises, in parts by weight: C15-19 alkane 13-14 parts, ascorbyl tetraisopalmitate 0.1-0.2 part, squalane 4-6 parts, tocopheryl acetate 0.4-0.6 part, argan oil 0.8-1.2 part, biswax oil 0.1-0.3 part, orange oil 0.01-0.1 part, jasmine flower oil 0.1-0.3 part, geranium oil 0.01-0.3 part. Under the above preferred range, the double essence has better stability, moderate oil-water stratification, clear interface, and no white middle layer for a long time.

[0023] Preferably, the humectant is selected from at least one of glycerol, panthenol, sugar isomer, dihydric alcohol; and / or

[0024] The metal chelator is selected from at least one of disodium ethylenediaminetetraacetate, octanohydroxamic acid, ethylenediamine disuccinic acid, methylglycine diacetic acid; and / or

[0025] The pH adjuster is selected from at least one of citric acid and its citrate, malic acid and its malate, tartaric acid and its tartrate; and / or

[0026] The thickening agent is selected from at least one of sodium chloride, magnesium sulfate, potassium chloride, sodium sulfate, dimethicone, phenyl silicone oil, carbomer, hydroxyethyl cellulose; and / or

[0027] The antioxidant is selected from at least one of sodium bisulfite, butylated hydroxytoluene, tertiary butyl hydroquinone, propyl gallate, butylated hydroxyanisole; and / or

[0028] The preservative is selected from at least one of p-hydroxyacetophenone, nipagin ester preservative, phenoxyethanol, benzoic acid and its salt, sorbic acid and its salt, methyl isothiazolinone.

[0029] Preferably, the humectant comprises, in parts by weight: glycerol 1-2 parts, dihydric alcohol 5-7 parts, panthenol 1-2 parts, sugar isomer 0.4-0.6 parts. Further preferably, the dihydric alcohol is 1,3-propanediol and 1,2-hexanediol.

[0030] Further, the present application claims to protect a preparation method of a double essence, comprising the following steps: heating and uniformly mixing each component of water phase according to formula amount to obtain water phase; heating and uniformly mixing each component of oil phase according to formula amount to obtain oil phase; mixing the oil phase and the water phase uniformly, to obtain the double essence.

[0031] Further, the present application claims to protect the application of the double essence in preparing a cosmetic for inhibiting the activity of hyaluronidase or for soothing and repairing skin.

[0032] The present application has the following beneficial effects:

[0033] (1) The present application provides a plant oil composition comprising double purple oil, jasmine flower oil and myrtle geranium flower oil, which can synergistically inhibit the activity of hyaluronidase, reduce the decomposition of hyaluronic acid, and further maintain skin moisture and elasticity, protect and repair skin barrier, and soothe and repair skin.

[0034] (2) The present application further provides a double essence which is rich in various functional ingredients, and the ingredients can prevent damage to the skin barrier, promote the repair process of the damaged skin barrier, and have good anti-allergic effect on sensitive skin with abnormal skin barrier function; at the same time, it has good whitening, anti-wrinkle, moisturizing and repairing effects.

[0035] (3) The double essence provided by the present application has oil phase in the upper layer and water phase in the lower layer, and the water phase and the oil phase are layered, so that the stability is high and the formula system will not produce a milky white intermediate layer for a long time. BRIEF DESCRIPTION OF DRAWINGS

[0036] Figure 1 The appearance schematic diagram of the double essence prepared for Example 1.

[0037] Figure 2 The appearance schematic diagram of the double essence prepared for Example 5.

[0038] Figure 3 The appearance schematic diagram of the double essence prepared for Example 11. DETAILED DESCRIPTION

[0039] The present application will be further described below in combination with specific examples, but the examples do not limit the present application in any form. Unless otherwise specified, the reagents, methods and devices used in the present application are conventional reagents, methods and devices in the technical field. Some of the raw materials used in the present application are shown in Table 1.

[0040] Table 1

[0041]

[0042]

[0043] Example 1-4 A double essence

[0044] The double essence provided by the present embodiment, according to the components and the weight parts of the components shown in Table 2, the preparation method comprises the following steps: mixing the components in the water phase, heating to 70℃, then stirring until completely dissolved, obtaining the water phase; mixing the components in the oil phase, then mixing with the water phase uniformly, obtaining the double essence. Figure 1 The schematic diagram of the appearance of the double essence prepared by the present embodiment. As shown in Figure 1 , the upper layer is the oil phase, the lower layer is the water phase, the water phase and the oil phase are layered, and the interface is clear, with high stability.

[0045] Table 2

[0046]

[0047]

[0048] Example 5-11

[0049] The double essence provided by the present embodiment, according to the components and the weight parts of the components shown in Table 3, the preparation method is as shown in Example 1.

[0050] Table 3

[0051]

[0052]

[0053] Figure 2 The schematic diagram of the appearance of the double essence prepared by Example 5. As shown in Figure 2 and Example 5, the double essence prepared by selecting hydrogenated polyisobutylene as oil and fat will appear pink oil layer on the upper layer, transparent water layer on the lower layer, slow stratification after shaking, and whitening. As shown in Example 6, the double essence prepared by selecting cetanol ethylhexanoate+C15-19 alkane as oil and fat will appear pink oil layer on the upper layer, transparent water layer on the lower layer, slow stratification after shaking, and slightly improved whitening, and the appearance diagram is basically as shown in Figure 2 . As shown in Example 7, the double essence prepared by selecting isohexadecane as oil and fat will appear pink oil layer on the upper layer, transparent water layer on the lower layer, slow stratification after shaking, and slightly improved whitening, but the oil and fat smell is large, and the appearance diagram is basically as shown in Figure 2 .

[0054] And as shown in Example 1 and Figure 1It can be seen that the double essence prepared by selecting C15-19 alkane as the oil and fat will have a pink oil layer on the upper layer, a transparent water layer on the lower layer, and the stratification is clear after shaking, without whitening and obvious odor. Therefore, the double essence prepared by selecting C15-19 alkane as the oil and fat will not have whitening phenomenon and no odor, and the stratification is clear after shaking.

[0055] Figure 3 The schematic diagram of the appearance of the double essence prepared for Example 11 is shown in Figure 3 As shown in Example 11, increasing the addition ratio of squalane in the combination, the double essence prepared has sufficient moisturizing degree, but the water layer is obviously yellow, and the oil layer fades quickly, and the phenomenon of obvious fading appears. In Examples 8-10, increasing the ratio of glycerin, panthenol and sugar isomer in the combination, the same phenomenon of obvious yellowing of the water layer and quick fading of the oil layer appears, and the appearance is basically as shown in Figure 3 Figure 3

[0056] Double essences provided by Comparative Examples 1-4 are prepared according to the components and weight parts of the components shown in Table 4, and the preparation method is as shown in Example 1.

[0057] Double essences provided by Comparative Examples 1-4 are prepared according to the components and weight parts of the components shown in Table 4, and the preparation method is as shown in Example 1.

[0058] Table 4

[0059]

[0060]

[0061] Stability test of Test Example 1

[0062] The double essence prepared by Example 1 is subjected to accelerated stability test, and the accelerated stability test items are shown in Table 5.

[0063] Table 5: Accelerated stability test items and detection methods

[0064]

[0065] The results of the accelerated stability test of the double essence prepared by Example 1 are shown in Table 6. As shown in Table 6, the double essence prepared by Example 1 is subjected to 3-month accelerated stability test, and the difference between the sensory and physical and chemical indexes before and after the test is not large, the stability is qualified, and it is suitable for storage at room temperature and 5±1℃.

[0066] Table 6: Accelerated stability test results of the double essence prepared by Example 1

[0067]

[0068] Efficiency evaluation test of Test Example 2​​

[0069] (1) Soothing-repairing effect test - hyaluronidase inhibition

[0070] Hyaluronic acid is widely present in the cell matrix and is one of the main components of the cell matrix and interstitium, which helps to maintain skin moisture and elasticity, and protects and repairs the skin barrier function. By inhibiting the activity of hyaluronidase, the degradation of hyaluronic acid can be effectively reduced, thereby reducing the release of histamine and inflammatory factors, and playing a certain soothing, anti-allergic and repairing effect.

[0071] Experimental method: 0.1 mL of 0.25 mmol / L calcium chloride solution and 0.5 mL of hyaluronidase solution (100 U / mL) were incubated at 37°C for 20 min; 0.5 mL of sample solution was added and incubated at 37°C for another 20 min; 0.5 mL of 0.5 g / L sodium hyaluronate solution (0.01 g of sodium hyaluronate was weighed into a beaker and dissolved in 20 mL of acetic acid buffer solution) was added and incubated at 37°C for 30 min, and then placed at room temperature for 5 min; 0.1 mL of 0.4 mol / L sodium hydroxide solution and 0.5 mL of acetylacetone solution (3.5 mL of acetylacetone was dissolved in 50 mL of 1 mol / L sodium carbonate solution to obtain acetylacetone solution) were added and heated in a boiling water bath for 15 min, then immediately cooled with ice water for 5 min; 1.0 mL of Ehrlich reagent (0.8 g of p-dimethylaminobenzaldehyde was dissolved in 15 mL of concentrated hydrochloric acid and 15 mL of anhydrous ethanol) was added and diluted with 3.0 mL of anhydrous ethanol, and then placed at room temperature for 25 min for color development. The absorbance value at 540 nm was measured by spectrophotometry. The 5% glycyrrhizic acid disodium solution was used as a positive control, and the inhibition rate of the sample on hyaluronidase was calculated according to the following formula:

[0072] Hyaluronidase inhibition rate (%) = [(A-B)-(C-D)] / (A-B) x 100%.

[0073] In the formula: A is the absorbance value of the blank group, which means using acetic acid buffer solution instead of sample solution; B is the absorbance value of the blank control group, which means using acetic acid buffer solution instead of sample solution and enzyme solution; C is the absorbance value of the sample group; D is the absorbance value of the sample control group, which means using acetic acid buffer solution instead of enzyme solution.

[0074] Table 7

[0075] Group Hyaluronidase inhibition rate (%) Example 2 81.43％ Comparative Example 1 63.41％ Comparative Example 2 69.35％ Comparative Example 3 69.05％ Comparative Example 4 70.45％ Positive control 75.35％

[0076] Table 7 is the inhibition rate of each group of samples on hyaluronidase. As can be seen from Table 7, the double essence provided by the application has a good inhibitory effect on hyaluronidase, and the inhibition rate is 81.43%, which is better than the positive control. The inhibition rate of the double essence of Example 1 on hyaluronidase is higher than that of Comparative Examples 1-4, which shows that it is difficult to achieve the technical effect of the application by using any two of the double purple oil, jasmine flower oil and myrtle geranium flower oil alone. The combination reflects the synergistic effect of double purple oil, jasmine flower oil and myrtle geranium flower oil on the inhibition rate of hyaluronidase, which can play a synergistic role in soothing and repairing the skin, protecting and repairing the skin barrier.

[0077] (2) Red blood cell hemolysis experiment (RBC experiment)

[0078] The irritability of the double essence was evaluated by red blood cell hemolysis experiment. Red blood cell hemolysis experiment is one of the alternative methods of rabbit eye irritation experiment (Draize test), and the basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin dissolved and the degree of denaturation. Internationally, RBC experiment is mainly used for eye irritation research of cosmetics and raw materials and other chemicals, and the grading standard is shown in Table 8. L / D is the ratio of HD50 (the sample concentration when 50% of red blood cells are hemolyzed) to DI (protein denaturation index).

[0079] Table 8

[0080] L / D Classification >100 Non-irritating 10 < L / D < 100 Mildly irritating 1 < L / D < 10 Slightly irritating 0.1 < L / D < 1 Moderately irritating L / D < 0.01 Severely irritating

[0081] Table 9

[0082] Group L / D Evaluation Example 1 >100 Non-irritating Example 2 >100 Non-irritating Example 3 >100 Non-irritating Comparative Example 1 >100 Non-irritating Comparative Example 2 >100 Non-irritating Comparative Example 3 >100 Non-irritating Comparative Example 4 >100 Non-irritating

[0083] The results of the red blood cell hemolysis experiment of the samples prepared by each group of examples and comparative examples are shown in Table 9. As can be seen from Table 9, the double essence prepared by the application has the characteristics of mildness and no irritation, and high safety.

[0084] The above examples are preferred embodiments of the application, but the embodiments of the application are not limited to the above examples, and any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the application shall be equivalent replacement methods, and all shall be included in the protection scope of the application.

Claims

1. A vegetable oil composition, characterized in that, The plant oil composition includes double purple oil, jasmine flower oil and geranium flower oil; the mass ratio of double purple oil, jasmine flower oil and geranium flower oil is 0.08-0.5:0.01-0.5:0.01-0.

5.

2. The vegetable oil composition according to claim 1, characterized in that, The mass ratio of the double purple oil, jasmine flower oil and geranium flower oil is 0.1-0.3:0.1-0.3:0.1-0.

3.

3. A method for preparing the vegetable oil composition according to any one of claims 1-2, characterized in that, The plant oil composition is prepared by mixing double purple oil, jasmine flower oil, and geranium flower oil evenly.

4. The use of the plant oil composition according to any one of claims 1-2 in the preparation of hyaluronidase-inhibiting products or in the preparation of cosmetics for soothing and repairing the skin.

5. A dual-effect serum, characterized in that, The dual essence comprises an aqueous phase and an oil phase; the oil phase comprises the plant oil composition according to any one of claims 1-2.

6. The dual-essence liquid according to claim 5, characterized in that, The dual-phase essence comprises an aqueous phase and an oil phase in a mass ratio of 65-75:25-35; The aqueous phase, by weight, comprises: 60-65 parts of Bifida ferment filtrate, 4-6 parts of birch sap, 0.06-0.1 parts of metal chelating agent, 0.8-3 parts of thickener, 0.02-0.08 parts of sodium hyaluronate, 6-15 parts of humectant, 0.03-0.07 parts of antioxidant, 0.01-0.05 parts of 4-butylresorcinol, 0.1-0.3 parts of acetylglucosamine, 0.17-0.3 parts of ergothioneine, 0.17-0.3 parts of Centella asiatica extract, 0.2-0.6 parts of preservative, and 0.12-0.16 parts of pH adjuster. The oil phase, by weight, comprises: 13-14 parts of C15-19 alkyl, 0.1-0.2 parts of ascorbic acid tetraisopalmitate, 3-10 parts of squalane, 0.3-0.7 parts of tocopheryl acetate, 0.8-1.2 parts of seven-seed white peony oil, 0.08-0.5 parts of double purple oil, 0.01-0.1 parts of orange oil, 0.01-0.5 parts of jasmine flower oil, and 0.01-0.5 parts of geranium flower oil.

7. The dual-essence liquid according to claim 6, characterized in that, The aqueous phase, by weight, comprises: 62-63 parts of Bifida ferment filtrate, 5-5.5 parts of birch sap, 0.06-0.1 parts of metal chelating agent, 0.8-1.5 parts of thickener, 0.04-0.06 parts of sodium hyaluronate, 6-15 parts of humectant, 0.04-0.06 parts of antioxidant, 0.01-0.03 parts of 4-butylresorcinol, 0.1-0.3 parts of acetylglucosamine, 0.17-0.25 parts of ergothioneine, 0.17-0.25 parts of Centella asiatica extract, 0.3-0.5 parts of preservative, and 0.12-0.16 parts of pH adjuster. The oil phase, by weight, comprises: 13-14 parts of C15-19 alkyl, 0.1-0.2 parts of ascorbic acid tetraisopalmitate, 4-6 parts of squalane, 0.4-0.6 parts of tocopheryl acetate, 0.8-1.2 parts of seven-seed white peony oil, 0.1-0.3 parts of double purple oil, 0.01-0.1 parts of orange oil, 0.1-0.3 parts of jasmine flower oil, and 0.01-0.3 parts of geranium flower oil.

8. The dual-essence liquid according to claim 6, characterized in that, The moisturizer is selected from at least one of glycerin, panthenol, saccharide isomers, and diols; and / or The metal chelating agent is selected from at least one of disodium ethylenediaminetetraacetate, octanoyl hydroxamic acid, ethylenediaminedisuccinic acid, and methylglycine diacetic acid; and / or The pH adjuster is selected from at least one of citric acid and its citrate, malic acid and its malate, and tartaric acid and its tartaric acid; and / or The thickener is selected from at least one of sodium chloride, magnesium sulfate, potassium chloride, sodium sulfate, polydimethylsiloxane, phenyl silicone oil, carbomer, and hydroxyethyl cellulose; and / or The antioxidant is selected from at least one of sodium bisulfite, butylated hydroxytoluene, tert-butylhydroquinone, propyl gallate, and butylated hydroxyanisole; and / or The preservative is selected from at least one of p-hydroxyacetophenone, parabens, phenoxyethanol, benzoic acid and its salts, sorbic acid and its salts, and methylisothiazolinone.

9. The method for preparing the dual-essence liquid according to any one of claims 5-8, characterized in that, The process includes the following steps: heating and mixing the components of the aqueous phase according to the formula to obtain the aqueous phase; heating and mixing the components of the oil phase according to the formula to obtain the oil phase; and mixing the oil phase and the aqueous phase evenly to obtain the dual essence.

10. The use of the dual essence according to any one of claims 5-8 in the preparation of hyaluronidase-inhibiting products or in the preparation of cosmetics for soothing and repairing the skin.

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