Anti-hair-loss composition containing cacumen biotae extract as well as preparation method and application of anti-hair-loss composition

Abstract

The invention discloses an anti-hair loss composition containing a cacumen biotae extract as well as a preparation method and application of the anti-hair loss composition, and belongs to the field of daily chemical products. The anti-hair loss composition comprises the following components: a cacumen biotae extract, acetyl tetrapeptide-3, a poloxamer solution, a carbomer swelling solution, an emulsifier, a surfactant, a penetration enhancer and a humectant. The anti-hair-loss composition is prepared by the following steps: S1, dispersing a cacumen biotae extract, an emulsifier and a surfactant to obtain an active matter oil phase; s2, mixing the poloxamer solution and the carbomer swelling solution with a penetration enhancer and a humectant, adding the active matter oil phase, and dispersing to form an emulsion; and S3, after the emulsion is cooled, adding a pH regulator, then adding acetyl tetrapeptide-3, and defoaming, thereby obtaining the product. The anti-alopecia composition provided by the invention can form gel when in use, and is continuously and slowly released, so that hair follicles are exposed to an effective drug concentration for a long time, and the effect of the anti-alopecia composition is improved.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products, specifically relating to an anti-hair loss composition containing arborvitae leaf extract, its preparation method, and its application. Background Technology

[0002] Arborvitae leaf extract is rich in flavonoids (such as quercetin and kaempferol) and phenolic acids (such as protocatechuic aldehyde and gallic acid), which can effectively inhibit 5α-reductase activity, thereby reducing DHT concentration. At the same time, it also has multiple effects such as anti-inflammation, promoting local microcirculation, reducing oxidative damage, and protecting hair follicle cells from oxidative stress. It intervenes in the hair loss process from the root and is a natural anti-hair loss ingredient with multi-pathway action.

[0003] Currently, most anti-hair loss products on the market are liquid formulations (such as water-based or alcohol-based products). After being applied to the scalp, the active ingredients are easily washed away or lost due to sweat, sebum secretion, or daily activities, failing to effectively remain at the treatment site. This results in a short actual contact time between active ingredients such as arborvitae leaf extract and hair follicles, making it difficult to achieve a sustained and effective intervention. Furthermore, existing products often employ simple dissolution technologies, making it difficult for the active ingredients in arborvitae leaf extract to effectively penetrate this barrier and reach the deep hair follicle papilla cells. This causes a large amount of active ingredients to remain on the skin surface, and poor penetration becomes another bottleneck restricting their efficacy.

[0004] Therefore, there is an urgent need in the field for a novel anti-hair loss composition that can solve the above problems. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this invention is to provide an anti-hair loss composition containing Platycladus orientalis leaf extract, its preparation method and application.

[0006] The first aspect of this invention is to provide a method for preparing an anti-hair loss composition containing Platycladus orientalis leaf extract, comprising the following steps: S1: Disperse the extract of Platycladus orientalis leaves, emulsifier and surfactant to obtain the active oil phase; S2: Mix poloxamer solution, carbomer swelling solution with penetration enhancer and moisturizer, add active oil phase, and disperse to form emulsion; S3: After the emulsion cools down, add a pH adjuster, then add acetyl tetrapeptide-3. After defoaming, the anti-hair loss composition containing arborvitae leaf extract is obtained.

[0007] In some embodiments, the poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5°C, wherein the amount of deionized water is 2-3 times the mass of poloxamer 407; the carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 3-5°C, wherein the amount of deionized water is 0.5-1 times the mass of carbomer 980.

[0008] It should be noted that poloxamer 407 has the property of cold melting and hot gelling, and must be prepared into an aqueous solution at low temperature. Carbomer needs to be pre-swollen in order to fully exert its thickening and gelling effect.

[0009] Poloxamer 407 is a triblock copolymer with a PEO-PPO-PEO structure. At low temperatures (<20℃), the PPO segments are hydrophilic, and the molecular chains flow freely in the solution, exhibiting a liquid state. At high temperatures (≥35℃), the PPO segments become hydrophobic and spontaneously aggregate to form a dense hydrophobic core in order to escape the aqueous environment, while the PEO segments remain hydrophilic, forming a hydrophilic shell around the core, resulting in a semi-solid physical gel. Carbomer is a polyacrylic acid polymer. Under neutral conditions (pH~7), most of the carboxyl groups on the carbomer molecular chains ionize into negatively charged carboxylate ions. Due to the repulsion of like charges, the molecular chains extend, resulting in a flowable liquid state. Under weakly acidic conditions (pH~5.5), the H+ in the solution... + As the concentration increases, carboxylate ions will recombine with H+. + The carboxyl groups revert to neutral, the electrostatic repulsion disappears, and the molecular chains no longer extend but instead curl and bend. These neutral carboxyl groups cross-link with each other through hydrogen bonds, forming a strong gel. When the product is applied to the scalp, body temperature (~35℃) and weak acidity (pH ~5.5) act simultaneously and synchronously on the system. The two effects reinforce each other, forming a complex hydrogel network that can encapsulate effective ingredients such as arborvitae leaf extract, thereby achieving long-lasting sustained release.

[0010] In some embodiments, the pH adjuster is selected from at least one of triethanolamine and aminomethylpropanol; the pH adjuster is adjusted to a pH of 7.0 ± 0.5.

[0011] In some embodiments, in S1, the dispersion time is 20-40 min and the dispersion temperature is 20-30℃; in S2, the shear speed used for dispersion is 350-450 rpm, the dispersion temperature is 10-15℃, and the dispersion time is 10-35 min.

[0012] In some embodiments, in S3, defoaming is performed by stirring at 4-5°C for 15-25 minutes.

[0013] A second aspect of the present invention is to provide an anti-hair loss composition containing arborvitae leaf extract.

[0014] In some embodiments, the anti-hair loss composition comprises, by weight, the following components: 3-5 parts of Platycladus orientalis leaf extract, 0.1-1 parts of acetyl tetrapeptide-3, 50-60 parts of poloxamer solution, 0.5-1 parts of carbomer swelling solution, 1-5 parts of emulsifier, 3-8 parts of surfactant, 15-20 parts of penetration enhancer, and 2-5 parts of moisturizer.

[0015] In some embodiments, the emulsifier is selected from at least one of caprylic / capric triglyceride, squalane, and isononyl isononanoate; the surfactant is hydrogenated castor oil; the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:1-3; and the humectant is selected from at least one of glycerin, propylene glycol, and panthenol.

[0016] It should be noted that the dipropylene glycol and 1,3-butanediol in the penetration enhancer can reversibly disrupt the lipid structure of the stratum corneum, reduce the resistance of the skin barrier, and help the active ingredients penetrate.

[0017] A third aspect of the present invention is to provide an anti-hair loss composition containing Platycladus orientalis leaf extract in the preparation of anti-hair loss shampoo and conditioner products.

[0018] In some embodiments, the anti-hair loss shampoo and conditioner also includes the following ingredients: menthol, argan kernel oil, jojoba seed oil, shea butter, ginger root extract, aloe vera leaf extract, and hydrolyzed wheat protein.

[0019] This invention does not limit the amount of ingredients used in anti-hair loss shampoo and conditioner products; the amount can be adjusted according to the actual shampoo and conditioner product.

[0020] Compared with the prior art, the present invention has the following beneficial effects: 1. The anti-hair loss composition containing Platycladus orientalis leaf extract provided by this invention can remain liquid in a storage environment. When applied to the scalp (body temperature ~35℃, pH ~5.5), it triggers the aggregation of hydrophobic segments of poloxamer and the cross-linking of molecular chains of carbomer, forming a gel network that encapsulates the active ingredients. The gel network effectively prevents the loss of ingredients due to sweat and sebum, keeping active ingredients such as Platycladus orientalis leaf extract at the site of action for a long time. Because the concentration of active ingredients (such as Platycladus orientalis leaf extract) in the gel is much higher than that in the surrounding skin tissue, the molecules will spontaneously and continuously release slowly through the micropores of the gel network, exposing the hair follicles to an effective drug concentration for a long time, greatly improving the efficacy of the anti-hair loss composition.

[0021] 2. Since most of the core active ingredients in Platycladus orientalis leaf extract (such as flavonoids like quercetin) are fat-soluble, they are difficult to dissolve in aqueous formulations. Therefore, in preparing the anti-hair loss composition containing Platycladus orientalis leaf extract, this invention uses emulsifiers, surfactants, and active ingredients to form an emulsion. The emulsion can dissolve and encapsulate these fat-soluble active ingredients, ensuring they are in a deliverable state. In addition, the emulsion has good wetting and spreading properties, which can increase the effective contact area with the skin, thereby increasing the probability and efficiency of penetration. Detailed Implementation

[0022] The present invention will be further described in detail below with reference to specific embodiments.

[0023] Example 1 A hair loss prevention composition containing Platycladus orientalis leaf extract comprises the following components in parts by weight: 4 parts Platycladus orientalis leaf extract, 0.6 parts acetyl tetrapeptide-3, 55 parts poloxamer solution, 0.8 parts carbomer swelling solution, 3 parts caprylic / capric triglyceride, 5 parts hydrogenated castor oil, 18 parts penetration enhancer, and 3 parts glycerin; wherein the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:2.

[0024] The above-mentioned anti-hair loss composition containing Platycladus orientalis leaf extract was prepared by the following steps: S1: The active ingredient oil phase was obtained by stirring the extract of Platycladus orientalis leaf, caprylic / capric triglyceride and hydrogenated castor oil at 25°C for 30 min. S2: Poloxamer solution, carbomer swelling solution, penetration enhancer, and glycerin are mixed, and the active ingredient oil phase is added. The mixture is sheared and dispersed at 400 rpm and 12°C for 20 min to form an emulsion. The poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5°C, and the amount of deionized water is twice the mass of poloxamer 407. The carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 4°C, and the amount of deionized water is 0.8 times the mass of carbomer 980. S3: After the emulsion cools down, add triethanolamine to adjust the pH to 7.0±0.5, then add acetyl tetrapeptide-3, and stir for 20 minutes at 4°C to defoam, thus obtaining the anti-hair loss composition containing arborvitae leaf extract.

[0025] The above-mentioned anti-hair loss composition containing arborvitae leaf extract can be used in anti-hair loss shampoo and conditioner products.

[0026] The anti-hair loss shampoo and conditioner contains the following ingredients by weight percentage: 0.7% anti-hair loss composition containing arborvitae leaf extract, 0.7% menthol, 0.5% argan kernel oil, 0.5% jojoba seed oil, 0.5% shea butter, 0.5% ginger root extract, 0.5% aloe vera leaf extract, 0.35% hydrolyzed wheat protein, and the balance being water.

[0027] Example 2 A hair loss prevention composition containing Platycladus orientalis leaf extract comprises the following components in parts by weight: 5 parts Platycladus orientalis leaf extract, 1 part acetyl tetrapeptide-3, 60 parts poloxamer solution, 1 part carbomer swelling solution, 5 parts squalane, 8 parts hydrogenated castor oil, 20 parts penetration enhancer, and 5 parts propylene glycol; wherein the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:3.

[0028] The above-mentioned anti-hair loss composition containing Platycladus orientalis leaf extract was prepared by the following steps: S1: The active ingredient oil phase was obtained by stirring the arborvitae leaf extract, squalane and hydrogenated castor oil at 30°C for 20 min. S2: Poloxamer solution, carbomer swelling solution, penetration enhancer, and propylene glycol are mixed, and the active ingredient oil phase is added. The mixture is sheared and dispersed at 450 rpm and 10°C for 35 min to form an emulsion. The poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5°C, and the amount of deionized water is 3 times the mass of poloxamer 407. The carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 5°C, and the amount of deionized water is 1 times the mass of carbomer 980. S3: After the emulsion cools down, add aminomethylpropanol to adjust the pH to 7.0±0.5, then add acetyl tetrapeptide-3, and stir for 25 minutes at 5°C to defoam, thus obtaining the anti-hair loss composition containing arborvitae leaf extract.

[0029] The above-mentioned anti-hair loss composition containing arborvitae leaf extract can be used in anti-hair loss shampoo and conditioner products.

[0030] The anti-hair loss shampoo and conditioner contains the following ingredients by weight percentage: 0.8% anti-hair loss composition containing arborvitae leaf extract, 0.8% menthol, 0.6% argan kernel oil, 0.6% jojoba seed oil, 0.6% shea butter, 0.6% ginger root extract, 0.6% aloe vera leaf extract, 0.4% hydrolyzed wheat protein, and the balance being water.

[0031] Example 3 A hair loss prevention composition containing Platycladus orientalis leaf extract comprises the following components in parts by weight: 3 parts Platycladus orientalis leaf extract, 0.1 parts acetyl tetrapeptide-3, 50 parts poloxamer solution, 0.5 parts carbomer swelling solution, 1 part isononyl isononanoate, 3 parts hydrogenated castor oil, 15 parts penetration enhancer, and 2 parts panthenol; wherein the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:1.

[0032] The above-mentioned anti-hair loss composition containing Platycladus orientalis leaf extract was prepared by the following steps: S1: The active ingredient oil phase was obtained by stirring the extract of Platycladus orientalis leaves, isononyl isononanoate and hydrogenated castor oil at 20°C for 40 min. S2: Poloxamer solution, carbomer swelling solution, penetration enhancer, and panthenol are mixed, and the active ingredient oil phase is added. The mixture is sheared and dispersed at 350 rpm and 10°C for 10 min to form an emulsion. The poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5°C, and the amount of deionized water is twice the mass of poloxamer 407. The carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 3°C, and the amount of deionized water is 0.5 times the mass of carbomer 980. S3: After the emulsion cools down, add triethanolamine to adjust the pH to 7.0±0.5, then add acetyl tetrapeptide-3, and stir for 15 minutes at 4°C to defoam, thus obtaining the anti-hair loss composition containing arborvitae leaf extract.

[0033] The above-mentioned anti-hair loss composition containing arborvitae leaf extract can be used in anti-hair loss shampoo and conditioner products.

[0034] The anti-hair loss shampoo and conditioner contains the following ingredients by weight percentage: 0.5% anti-hair loss composition containing arborvitae leaf extract, 0.6% menthol, 0.4% argan kernel oil, 0.4% jojoba seed oil, 0.4% shea butter, 0.4% ginger root extract, 0.4% aloe vera leaf extract, 0.3% hydrolyzed wheat protein, and the balance being water.

[0035] Example 4 A hair loss prevention composition containing Platycladus orientalis leaf extract comprises the following components in parts by weight: 4 parts Platycladus orientalis leaf extract, 0.8 parts acetyl tetrapeptide-3, 52 parts poloxamer solution, 0.6 parts carbomer swelling solution, 2 parts caprylic / capric triglyceride, 7 parts hydrogenated castor oil, 16 parts penetration enhancer, and 3 parts glycerin; wherein the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:2.

[0036] The above-mentioned anti-hair loss composition containing Platycladus orientalis leaf extract was prepared by the following steps: S1: The active ingredient oil phase was obtained by dispersing and mixing the extract of Platycladus orientalis leaf, caprylic / capric triglyceride and hydrogenated castor oil at 25°C for 35 min; S2: Poloxamer solution, carbomer swelling solution, penetration enhancer, and glycerin are mixed, and the active ingredient oil phase is added. The mixture is sheared and dispersed at 400 rpm and 13°C for 25 min to form an emulsion. The poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5°C, and the amount of deionized water is 2.5 times the mass of poloxamer 407. The carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 4°C, and the amount of deionized water is 0.9 times the mass of carbomer 980. S3: After the emulsion cools down, add aminomethylpropanol to adjust the pH to 7.0±0.5, then add acetyl tetrapeptide-3, and stir for 20 minutes at 5°C to defoam, thus obtaining the anti-hair loss composition containing arborvitae leaf extract.

[0037] The above-mentioned anti-hair loss composition containing arborvitae leaf extract can be used in anti-hair loss shampoo and conditioner products.

[0038] The anti-hair loss shampoo and conditioner contains the following ingredients by weight percentage: 0.6% anti-hair loss composition containing Platycladus orientalis leaf extract, 0.65% menthol, 0.45% Argan kernel oil, 0.45% jojoba seed oil, 0.45% shea butter, 0.45% ginger root extract, 0.45% aloe vera leaf extract, 0.35% hydrolyzed wheat protein, and the balance being water.

[0039] Example 5 A hair loss prevention composition containing Platycladus orientalis leaf extract comprises the following components in parts by weight: 4 parts Platycladus orientalis leaf extract, 0.3 parts acetyl tetrapeptide-3, 58 parts poloxamer solution, 0.9 parts carbomer swelling solution, 4 parts squalane, 4 parts hydrogenated castor oil, 19 parts penetration enhancer, and 4 parts propylene glycol; wherein the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:2.

[0040] The above-mentioned anti-hair loss composition containing Platycladus orientalis leaf extract was prepared by the following steps: S1: The active ingredient oil phase was obtained by stirring the arborvitae leaf extract, squalane and hydrogenated castor oil at 25°C for 35 min. S2: Poloxamer solution, carbomer swelling solution, penetration enhancer, and propylene glycol are mixed, and the active ingredient oil phase is added. The mixture is sheared and dispersed at 400 rpm and 12°C for 15 min to form an emulsion. The poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5°C, and the amount of deionized water is twice the mass of poloxamer 407. The carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 5°C, and the amount of deionized water is 0.6 times the mass of carbomer 980. S3: After the emulsion cools down, add triethanolamine to adjust the pH to 7.0±0.5, then add acetyl tetrapeptide-3, and stir for 20 minutes at 4°C to defoam, thus obtaining the anti-hair loss composition containing arborvitae leaf extract.

[0041] The above-mentioned anti-hair loss composition containing arborvitae leaf extract can be used in anti-hair loss shampoo and conditioner products.

[0042] The anti-hair loss shampoo and conditioner contains the following ingredients by weight percentage: 0.7% anti-hair loss composition containing arborvitae leaf extract, 0.75% menthol, 0.55% argan kernel oil, 0.55% jojoba seed oil, 0.55% shea butter, 0.55% ginger root extract, 0.55% aloe vera leaf extract, 0.35% hydrolyzed wheat protein, and the balance being water.

[0043] Comparative Example 1 It is basically the same as Example 1, except that: no poloxamer solution and carbomer swelling solution are added.

[0044] Comparative Example 2 It is basically the same as Example 1, except that no emulsifier and surfactant are added.

[0045] Comparative Example 3 It is basically the same as Example 1, except that acetyl tetrapeptide-3 is not added.

[0046] Comparative Example 4 It is basically the same as Example 1, except that no penetration enhancer is added.

[0047] The user experience and effects of the anti-hair loss compositions prepared in Examples 1-5 and Comparative Examples 1-4 were tested. The test method was as follows: 90 subjects with mild to moderate hair loss were randomly divided into 9 groups. The anti-hair loss compositions were applied to the scalp three times a day for 8 weeks. The user experience was recorded during the period. The user experience was based on their own feelings and referenced the rating scale. The rating scale used a 10-point scale (1 point indicates that they are very dissatisfied with the test product, and 10 points indicates that they are very satisfied with the test product). After 8 weeks, the doctor evaluated the treatment effect. The test results are shown in Table 1.

[0048] Table 1 As shown in Table 1, the anti-hair loss composition containing Platycladus orientalis leaf extract provided in the embodiments of the present invention scores higher in terms of texture and durability, and its therapeutic effect on hair loss is also significantly better than that of the comparative example.

[0049] Comparative Example 1 lost its gel network and became a traditional liquid, resulting in a lower score for lasting comfort. Participants generally reported that "the product was no longer noticeable after application, and they suspected it was being rubbed off or evaporated," leading to a significant decrease in overall satisfaction. Comparative Example 2, due to the absence of emulsifiers and surfactants, resulted in a sticky texture, slow absorption, and a feeling of heaviness on the scalp, resulting in the lowest overall score. Comparative Example 3, due to the absence of the active ingredient acetyl tetrapeptide-3, had reduced efficacy. Comparative Example 4, due to the absence of penetration enhancers, had a slower absorption rate, affecting the treatment effect.

[0050] The above descriptions are merely some embodiments of the present invention. Those skilled in the art can make various modifications and improvements without departing from the inventive concept of the present invention, and these all fall within the scope of protection of the present invention.

Claims

1. A method for preparing a hair loss prevention composition containing Platycladus orientalis leaf extract, characterized in that, Includes the following steps: S1: Disperse the extract of Platycladus orientalis leaves, emulsifier and surfactant to obtain the active oil phase; S2: Mix poloxamer solution, carbomer swelling solution with penetration enhancer and moisturizer, add the active ingredient oil phase, and disperse to form an emulsion; S3: After the emulsion cools down, add a pH adjuster, then add acetyl tetrapeptide-3, and after defoaming, the hair loss prevention composition containing arborvitae leaf extract is obtained.

2. The method for preparing the anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 1, characterized in that, The poloxamer solution is obtained by dissolving poloxamer 407 in deionized water at ≤5℃, with the amount of deionized water being 2-3 times the mass of poloxamer 407; the carbomer swelling solution is obtained by dispersing carbomer 980 in deionized water at 3-5℃, with the amount of deionized water being 0.5-1 times the mass of carbomer 980.

3. The method for preparing the anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 1, characterized in that, The pH adjuster is selected from at least one of triethanolamine and aminomethylpropanol; the pH adjuster is used to adjust the pH to 7.0 ± 0.

5.

4. The method for preparing the anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 1, characterized in that, In step S1, the dispersion time is 20-40 min and the dispersion temperature is 20-30℃; in step S2, the shearing speed used for dispersion is 350-450 rpm, the dispersion temperature is 10-15℃, and the dispersion time is 10-35 min.

5. The method for preparing the anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 1, characterized in that, In step S3, defoaming is performed by stirring at 4-5℃ for 15-25 minutes.

6. A hair loss prevention composition containing Platycladus orientalis leaf extract is prepared by the preparation method according to any one of claims 1-5.

7. The anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 6, characterized in that, The anti-hair loss composition comprises, by weight, 3-5 parts of Platycladus orientalis leaf extract, 0.1-1 parts of acetyl tetrapeptide-3, 50-60 parts of poloxamer solution, 0.5-1 parts of carbomer swelling solution, 1-5 parts of emulsifier, 3-8 parts of surfactant, 15-20 parts of penetration enhancer, and 2-5 parts of moisturizer.

8. The anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 7, characterized in that, The emulsifier is selected from at least one of caprylic / capric triglyceride, squalane, and isononyl isononyl isononyl ester; the surfactant is hydrogenated castor oil; the penetration enhancer is obtained by mixing dipropylene glycol and 1,3-butanediol in a mass ratio of 3:1-3; and the humectant is selected from at least one of glycerin, propylene glycol, and panthenol.

9. The use of the anti-hair loss composition containing Platycladus orientalis leaf extract as described in claim 8 in the preparation of an anti-hair loss shampoo and conditioner.

10. The application of the anti-hair loss composition containing Platycladus orientalis leaf extract according to claim 9 in the preparation of anti-hair loss shampoo and conditioner products, characterized in that, The hair loss prevention shampoo and conditioner also includes the following ingredients: menthol, argan kernel oil, jojoba seed oil, shea butter, ginger root extract, aloe vera leaf extract, and hydrolyzed wheat protein.

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