Anti-oxidation whitening traditional Chinese medicine hydrogel composition and preparation method thereof

Abstract

According to the composition, rhizoma bletillae, radix angelicae, ramie roots, moutan bark and herba violae serve as raw materials, ultrasonic extraction is conducted through an ethanol solvent to obtain a traditional Chinese medicine alcohol extracting solution, and the traditional Chinese medicine alcohol extracting solution and auxiliary materials such as carbomer, propylene glycol and triethanolamine are compounded into hydrogel. The preparation process comprises the following steps: crushing the medicinal materials, carrying out ultrasonic extraction (optimal conditions are as follows: the ethanol concentration is 40%, the solid-liquid ratio is 1: 12, the time is 30 minutes, and the number of times is 3), and mixing the auxiliary materials. The hydrogel disclosed by the invention has remarkable oxidation resistance (the DPPH removal rate is 89.80 + / -0.24%) and a whitening effect (the tyrosinase inhibition rate is 78.41 + / -1.18%), is good in transdermal absorption and excellent in physical and chemical stability, and can be used for solving the problems of dull yellow skin, hyperpigmentation or anti-oxidation nursing and the like.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of functional cosmetic technology, in particular to an anti-oxidation whitening traditional Chinese medicine hydrogel composition and a preparation method thereof.

BACKGROUND

[0002] With the vigorous development of social economy, life pressure is everywhere and increasing day by day. Modern urban population gradually steps into the fast-paced life track, diet and work schedule are increasingly irregular, long-term overtime, sleep deprivation and other phenomena are common. At the same time, the current living environment also faces many challenges, strong ultraviolet radiation, and people's long-term exposure to radiation generated by mobile phones, computers and other electronic screens. Under the combined influence of these adverse factors, the skin condition of modern women is getting worse and worse, becoming pitted, dull, yellowish, pigmented, and freckled. Therefore, improving skin color has become an important field of concern for modern people, and the development of skin care products with whitening effect has also attracted much attention.

[0003] Skin is an important organ of the human body, and maintaining its structural and functional integrity is of great significance to maintaining the health of the body. At present, China has become the second largest cosmetics consumer market in the world. With the continuous growth of national income, people's demand for cosmetics is showing an upward trend. The core function of whitening cosmetics is to accurately regulate the pigment metabolism process of the skin, effectively inhibit the formation and deposition of melanin, and thus achieve the ideal effect of whitening the skin and evening the skin color. In addition, based on the traditional aesthetic concept of "white is beautiful", whitening skin care products have become a key component of functional skin care products, accounting for one-third of the beauty and skin care product market, and naturally become the focus of research institutions and production enterprises.

[0004] Generally, some active ingredients with specific functions are added in whitening products, such as substances capable of inhibiting tyrosinase activity, antioxidants, vitamin C, arbutin, nicotinamide, etc. These ingredients work synergistically to significantly reduce the synthesis and deposition of melanin, accelerate skin metabolism, and thus brighten the skin color. However, despite the significant effect of these ingredients on whitening, they often come with many side effects in actual use. For example, kojic acid mainly captures copper ions in the active site of tyrosinase, thereby inhibiting the activity of tyrosinase, preventing the generation of melanin from the source, and achieving the purpose of whitening the skin. However, kojic acid has obvious limitations. It is chemically unstable and easily decomposed under the action of light and heat, and easily oxidized in air. It also has a certain degree of irritating effect on the skin. In contrast, traditional Chinese medicine whitening has been favored by many beauty enthusiasts due to its unique advantages of long history, significant effect, and high safety. Traditional Chinese medicine adheres to the unique concept of internal regulation and external care, providing comprehensive care for the skin. The methods of traditional Chinese medicine whitening are flexible and diverse, which can improve body function from the source through internal regulation, or directly act on the skin through external application. Its biggest advantage and characteristic is to return to nature and use safe materials. Traditional Chinese medicine culture has a long history, based on the theory of "taking similar objects and transforming excess and deficiency", the Chinese medicine with "white" often becomes a commonly used medicinal material for whitening.

[0005] Bletilla striata has the effects of astringing, stopping bleeding, detumescence, and promoting tissue regeneration. It contains 40-50% natural water-soluble bletilla striata polysaccharides, mainly composed of glucosan, which can dissolve in water and form a viscous hydrophilic glue liquid, with strong free radical scavenging ability, which can effectively scavenge DPPH and hydroxyl radicals. Angelica dahurica has the effects of whitening, dispelling wind and dampness, unblocking channels and relieving pain, etc. The main component is coumarin compound. Modern medical research has confirmed that angelica dahurica can effectively eliminate the excessive accumulation of pigments in tissues, and has good therapeutic effect on various skin problems such as chloasma, vitiligo, and acne. In addition, angelica dahurica extract has good inhibitory effect on tyrosinase. SUMMARY

[0006] One of the technical problems to be solved by the present application is to provide an antioxidant whitening traditional Chinese medicine hydrogel composition. The composition realizes efficient antioxidant activity and tyrosinase inhibition ability through optimization of extraction and formula process, and is used for improving problems such as dark yellow skin, pigmentation, and antioxidant care.

[0007] The present application is to solve one of the above technical problems:

[0008] An anti-oxidation whitening traditional Chinese medicine hydrogel composition comprises a traditional Chinese medicine extract obtained from medicinal material raw materials by extraction, and the medicinal material raw materials are as follows: 5-15 parts of white bletilla, 1.5-10 parts of white peony root, 5-15 parts of ramie root, 3-10 parts of cortex moutan, and 1.5-10 parts of purple flower.

[0009] Further, the traditional Chinese medicine extract is obtained from medicinal material raw materials by ultrasonic extraction with an ethanol solvent.

[0010] Further, the traditional Chinese medicine extract is obtained from medicinal material raw materials by ultrasonic extraction with an ethanol solvent, and the medicinal material raw materials are as follows: 7.5 parts of white bletilla, 2.5 parts of white peony root, 7.5 parts of ramie root, 5 parts of cortex moutan, and 2.5 parts of purple flower.

[0011] Further, the composition further comprises a hydrogel auxiliary material, and the weight percentage of each component in the composition is as follows: 10-30% of the traditional Chinese medicine extract, 10-30% of the hydrogel auxiliary material, and the rest is deionized water.

[0012] Further, the hydrogel auxiliary material comprises carbomer, propylene glycol, triethanolamine, nicotinamide, borneol, nipagin methyl ester, cochineal solution, and gardenia essential oil; and the weight percentage of each component in the composition is as follows: 0.5% of carbomer, 5% of propylene glycol, 5% of triethanolamine, 0.5% of nicotinamide, 0.05% of borneol, 0.01% of nipagin methyl ester, 0.04% of cochineal, 0.0125% of gardenia essential oil, 10% of the traditional Chinese medicine extract, and the rest is deionized water.

[0013] Further, the preparation conditions of the traditional Chinese medicine extract are as follows: an ethanol concentration of 30-60%, a solid-liquid ratio of 1:8-14 g / mL, an ultrasonic time of 30-60 min, an extraction number of 2-4 times, and an ultrasonic power of 100-300 W.

[0014] Further, the preparation conditions of the traditional Chinese medicine extract are as follows: an ethanol concentration of 40%, a solid-liquid ratio of 1:12 g / mL, an ultrasonic time of 30 min, an extraction number of 3 times, and an ultrasonic power of 280 W.

[0015] The second technical problem to be solved by the present application is to provide a preparation method of an anti-oxidation whitening traditional Chinese medicine hydrogel composition, which realizes efficient anti-oxidation activity and tyrosinase inhibition capacity by optimizing the extraction and formula process, and is used for improving problems such as skin yellowing, pigmentation, and anti-oxidation care.

[0016] The present application solves the above-mentioned second technical problem in the following manner:

[0017] The preparation method of the anti-oxidation whitening traditional Chinese medicine hydrogel composition comprises the following steps:

[0018] (a) Bletilla striata, Angelica dahurica, Boehmeria nivea, Paeonia suffruticosa, Viola yedoensis are crushed to pass through a 100-mesh screen;

[0019] (b) Add ethanol solvent, under the conditions of ethanol concentration 30-60%, solid-liquid ratio 1:8-14 g / mL, ultrasonic time 30-60 min, extraction times 2-4 times, ultrasonic power 100-300 W, ultrasonic extraction is carried out;

[0020] (c) Centrifugal separation is performed to obtain supernatant, which is concentrated and diluted to 10 mL to obtain a traditional Chinese medicine extract;

[0021] (d) Carbopol is swelled with water, and propylene glycol, triethanolamine, nicotinamide, borneol, nipagin methyl ester, cochineal solution and gardenia essential oil are sequentially added;

[0022] (e) The traditional Chinese medicine extract is uniformly mixed with the mixture of step (d), and water is added to reach the target weight to obtain a hydrogel.

[0023] Further, the preparation conditions of the traditional Chinese medicine extract in step (b) are as follows: ethanol concentration 40%, solid-liquid ratio 1:12 g / mL, ultrasonic time 30 min, extraction times 3 times, and ultrasonic power 280 W.

[0024] Further, the mixing in step (e) is carried out at room temperature, and the stirring speed is 500-1000 r / min.

[0025] The present application has the following advantages:

[0026] High antioxidant and whitening efficiency: the DPPH free radical scavenging rate of the hydrogel reaches 89.80±0.24% (the highest average value can reach 92.2964±0.3309%), and the tyrosinase inhibition rate reaches 78.41±1.18%, which is significantly higher than that of the prior art, indicating that the hydrogel has excellent antioxidant capacity and whitening activity potential.

[0027] Excellent stability: the hydrogel has no delamination, discoloration or precipitation under the conditions of centrifugal stability test (3000 r / min, 300 min) and extreme temperature cycle (-20℃ to 50℃), and the pH value is stable at 8.87-8.98.

[0028] Good transdermal property: in vitro transdermal experiment, the DPPH scavenging rate is stable at more than 50% within 6 hours, indicating that the active ingredients effectively penetrate the skin.

[0029] Process innovation: ultrasonic-assisted ethanol extraction and response surface optimization method are used to improve the extraction efficiency and ingredient activity; the sensory evaluation system ensures the optimization of the appearance and touch of the preparation.

[0030] Safety and environmental protection: based on traditional Chinese medicine raw materials, the use of chemical additives is reduced, and the risk of skin irritation is reduced.

[0031] In summary, the present application adopts ultrasonic-assisted ethanol extraction technology to efficiently extract active ingredients from white and white peony root, etc. and successfully prepares a hydrogel preparation with stable physical and chemical properties. Through systematic in vitro evaluation experiments, it is confirmed that: 1) DPPH free radical scavenging experiment shows that the hydrogel has significant antioxidant activity; 2) tyrosinase inhibition experiment proves that it can effectively block the key pathway of melanin production; 3) transdermal absorption experiment shows that the preparation has good skin permeability. Through process optimization, the extraction efficiency of active ingredients is significantly improved. It can solve the problems of instability, easy oxidation and irritation of active ingredients in existing whitening products; and the problems of low extraction process efficiency, poor preparation stability and insufficient skin permeability of traditional Chinese medicine extracts in application.

[0032] In summary, the present application develops a traditional Chinese medicine compound hydrogel with simple process and stable performance; the traditional Chinese medicine compound hydrogel has the dual effects of whitening and antioxidant. BRIEF DESCRIPTION OF DRAWINGS

[0033] The present application will be further described below with reference to the accompanying drawings and examples.

[0034] Figure 1 The present application is a single-factor test result diagram in the example.

[0035] Figure 2 The present application is a response surface and contour plot of the influence of two-factor interaction on the antioxidant activity of traditional Chinese medicine alcohol extract.

[0036] Figure 3 The present application is a sensory evaluation diagram of the hydrogel.

[0037] Figure 4 The present application is an antioxidant detection diagram of the transdermal test. DETAILED DESCRIPTION

[0038] The technical solutions of the present application will be described clearly and completely below with reference to the accompanying drawings and specific embodiments. Based on the examples in the present application, all other examples obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present application. If the specific conditions are not specified in the examples, the conventional conditions or the conditions recommended by the manufacturer are used. If the reagents or instruments used are not specified by the manufacturer, they are all conventional products that can be purchased on the market. Figures 1-4 DETAILED DESCRIPTION

[0039] EXAMPLE

[0040] 1. Experimental method

[0041] 1.1 Optimization of traditional Chinese medicine extraction process

[0042] 1.1.1 Chinese medicine extraction

[0043] Bletilla striata 7.5 g, Angelica dahurica 2.5 g, Boehmeria nivea 7.5 g, Cortex Moutan 5 g, and Viola yedoensis 2.5 g were weighed, crushed, and passed through a 100-mesh sieve. One-tenth of the amount was taken and placed in a 50-mL centrifuge tube. Ethanol was added at a certain proportion of the mass of the medicinal materials, and ultrasonic extraction was performed at 4000 r / min for 10 min. The supernatant was concentrated and diluted to 10 mL.

[0044] 1.1.2 DPPH antioxidant activity detection

[0045] 40.00 mg of DPPH powder was precisely weighed, dissolved in 50 mL of anhydrous ethanol, and prepared into a 0.8 mg / mL DPPH stock solution, which was stored at 4°C in the dark. A 50% DPPH solution was prepared for use. The medicinal liquid extract was concentrated to less than 10 mL, centrifuged, and the supernatant was taken and diluted to 10 mL with water. A certain volume of medicinal liquid was taken and added with an equal volume of anhydrous ethanol. After vortexing and centrifugation, the supernatant was taken and added. In a 96-well plate, 100 μL of DPPH solution was added, followed by the addition of different concentrations of the sample solution to be tested. After incubation at 37°C in a constant-temperature shaker for 30 min in the dark, the absorbance was measured at 517 nm using an enzyme marker. The experiment was repeated three times in parallel. The sample addition conditions are as follows:

[0046] Table 1 DPPH antioxidant experiment sample addition conditions

[0047]

[0048] The calculation formula of the DPPH clearance rate is: Clearance rate (%) = [A-(B-C)] / A x 100%

[0049] Wherein: A is the absorbance of the blank group; B is the absorbance of the sample group; and C is the absorbance of the control group.

[0050] 1.1.3 Single-factor experiment

[0051] The effects of the material-liquid ratio (1:4, 1:8, 1:10, 1:12, 1:14), extraction times (1, 2, 3, 4, 5), time (15, 30, 45, 60, 75 min), ultrasonic power [20%, 40%, 60%, 80%, 100% (total power 700 w, frequency: 28 KHz)], and ethanol concentration (20%, 40%, 60%, 80%, 100%) on the antioxidant efficacy of the alcohol extract of Chinese medicine were investigated.

[0052] 1.1.4 Box-Behnken response surface design

[0053] Through single factor experiment, the ethanol concentration (A), the ratio of material to liquid (B), and the ultrasonic time (C) were determined as response variables, and the free radical scavenging rate (DPPH method) was determined as response value. According to the test factor level table in the following table, response surface optimization was carried out.

[0054] Table 2 Test factor level table of response surface

[0055]

[0056] 1.2 Optimization of hydrogel preparation process

[0057] 1.2.1 Hydrogel preparation process

[0058] A certain amount of ultrapure water was used to swell carbomer, and propylene glycol, triethanolamine, nicotinamide, menthol, nipagin methyl ester, cochineal solution, gardenia essential oil and other auxiliary materials were added. The above-mentioned traditional Chinese medicine extract was mixed uniformly and water was added to 20g to prepare the hydrogel. The best proportion of auxiliary materials was determined by sensory evaluation.

[0059] 1.2.2 Sensory evaluation

[0060] The carbomer was swelled with ultrapure water, and propylene glycol, triethanolamine, nicotinamide, menthol, nipagin methyl ester, cochineal solution, gardenia essential oil and other auxiliary materials were added. After being mixed uniformly, water was added to 20g. 15 evaluators performed sensory evaluation on the hydrogel according to the set scoring standard.

[0061] Table 3 Sensory evaluation scoring standard table

[0062]

[0063] 1.3 Physicochemical properties of hydrogel

[0064] The prepared hydrogel was subjected to centrifugal test (4000r / min, 5min), and the material body had no stratification and other abnormal phenomena. In addition, high temperature and low temperature were carried out, and the hydrogel was placed in a constant temperature box at 50℃ and-20℃ for 24h, respectively. The pH value was detected and it was observed whether the whitening cream had stratification, discoloration, particle precipitation or other abnormal phenomena of the material body under each condition.

[0065] 1.4 Viscosity test

[0066] The viscosity of the gel was tested at 25℃ using NDJ-5S rotary viscometer. After the value was constant, the viscosity value was read, and 3 samples were determined in parallel, and the average value was taken.

[0067] 1.5 In vitro transdermal experiment

[0068] Preparation of isolated skin: The abdomen of SD rats was shaved with depilatory cream, and the rats were sacrificed by decapitation. The abdominal skin was immediately excised, and the subcutaneous fat layer and connective tissue were carefully removed. The skin was washed with normal saline and dried with filter paper. The isolated skin was fixed between the supply pool and the receiving pool of a Franz diffusion cell, and 7 mL of normal saline was added to the receiving pool. After the bubbles were removed, the diffusion cell was sealed with sealing film. The temperature of the diffusion cell was adjusted to (37.0 ± 0.2) °C, and the skin was in close contact with the liquid surface under constant magnetic stirring at 600 r / min for 20 min (n = 3). 1 mL of hydrogel was evenly applied to the surface of the skin to ensure that the preparation was in full contact with the skin. At 0.5, 1, 2, 3, 4, 5, and 6 h, 3 mL of the receiving solution was removed, and an equal volume of normal saline at the same temperature was added to the receiving pool. After concentration, the receiving solution was measured for antioxidant activity. The in vitro transdermal absorption curve was plotted with the sampling time t as the abscissa and the DPPH clearance rate as the ordinate.

[0069] 1.6 Detection of inhibition of tyrosinase activity

[0070] Accurately weigh 80 mg of levodopa powder and dissolve it in 40 mL of PBS (pH = 6.8) to obtain a levodopa solution (2 mmol / L) by ultrasonic treatment for 10 min in the dark. Accurately weigh 50 KU of tyrosinase powder and add PBS to a 250 mL brown volumetric flask to obtain a tyrosinase solution with an activity of 200 U / mL. Prepare sample solutions by diluting the drug solution with PBS to concentrations of 100%, 80%, 60%, 40%, and 20% of the original drug solution. Add PBS, 40 μL of the sample solution to be tested at different concentrations, 40 μL of the levodopa solution, and 40 μL of the tyrosinase solution to a 96-well plate, respectively, and incubate at 37°C for 10 min in the dark. Then, add 40 μL of the tyrosinase solution and continue incubation for 20 min. Measure the absorbance at 457 nm using a microplate reader. Repeat the measurement three times in parallel. The inhibition rate of tyrosinase activity (%) = [(A-B)-(C-D)] / (A-B) x 100%. The sample addition conditions are shown in the following table:

[0071] Table 4 Detection of the inhibition rate of tyrosinase activity

[0072]

[0073] 2. Results

[0074] 2.1 Results of single-factor experiment

[0075] The results of the single-factor experiment are shown in Table 1. When the solid-liquid ratio was 1:12, the extraction was performed 3 times, the extraction time was 45 min, and the ultrasonic power was 280 W, the extraction yield of TFSP reached the peak. Figure 1

[0076] 2.2 Response surface experiment

[0077] ​2.2.1 Experimental design and results

[0078] The BBD response surface test group design and results are shown in Table 5. Multiple regression fitting analysis was performed to obtain the following regression equation:

[0079] DPPH clearance rate (%) = 87.58 - 1.44A - 6.64B - 2.25C + 4.41AC + 1.33BC - 3.25A2-

[0080] 6.78B 2 -0.53C 2

[0081] Table 5 BBD response surface test group design and results

[0082]

[0083]

[0084] 2.2.2 Analysis of variance

[0085] The experimental results are shown in Table 6. The model has significance (P < 0.05), i.e. the linear relationship between ethanol concentration, extraction times, extraction time and DPPH clearance rate is significant, and the model is reliable. The P value of the lack-of-fit term is greater than 0.05, indicating that the test has good stability. The quadratic C2 and the interaction term BC have a very significant effect on DPPH clearance rate; the quadratic A2 is significant. From the F value, the order of the effect of single factors on DPPH clearance rate is: ethanol concentration > extraction time > extraction times.

[0086] Table 6 Analysis of variance of response surface test

[0087]

[0088] 2.2.3 Interaction between two factors

[0089] The 3D graph and contour graph of the interaction between two factors are shown in Figure 2. The response surface graph of ethanol concentration has a large surface inclination, indicating that ethanol concentration and extraction time have a significant effect on DPPH clearance rate, while extraction time is less significant, which is consistent with the analysis of variance.

[0090] 2.2.4 Verification of response surface optimization

[0091] The optimal extraction process was obtained by analyzing the regression equation, which was 40% ethanol concentration, 30 min extraction time, and 3 extraction times. The theoretical DPPH clearance rate was 90.49%. Under this condition, three repeated verification tests were carried out, and the DPPH clearance rates were 92.67%, 92.05%, and 92.17% respectively, with an average of 92.2964±0.3309%, which was greater than the theoretical prediction value, indicating that the extraction process parameters obtained by the model optimization were reliable.

[0092] 2.3 Construction of sensory evaluation system and determination of preparation process

[0093] The results of the system sensory evaluation analysis are shown in Table 1. Figure 3 The final auxiliary material system ratio is as follows: carbomer 0.5% (0.1 g), propylene glycol 5% (1 g), triethanolamine 5% (1 g), borneol 0.05% (0.01 g), nicotinamide 0.5% (0.1 g), cochineal 0.04% (400 μL, 2 mg / mL), nipagin methyl ester 0.01% (0.002 g, ethanol assisted dissolution), gardenia essential oil 0.0125% (2.5 μL), drug solution 10% (2 mL), and deionized water to 20 g. The prepared hydrogel is a light pink transparent gel state with a fresh fragrance.

[0094] 2.4 Viscosity test

[0095] At 25°C, the hydrogel viscosity is 15900±100 mPa.s at a rotation speed of 006.0 RPM.

[0096] 2.5 Comprehensive evaluation of hydrogel physicochemical stability

[0097] The physicochemical characterization shows that the hydrogel exhibits excellent phase stability and pH tolerance. The centrifugal stability experiment (3000 r / min, 30 min) shows that the system has no layering and no precipitation, confirming that the three-dimensional network structure has ideal mechanical integrity. The accelerated stability test shows that under extreme temperature cycling (-20°C to 50°C), the pH value of the system remains stable, with a normal temperature group (25°C±1°C) of 8.96±0.019, a high temperature group (50°C±1°C, 7d) of 8.98±0.017, and a low temperature group (-20°C±1°C, 30d) of 8.87±0.012.

[0098] 2.6 Antioxidant and tyrosinase inhibitory activity analysis

[0099] The experimental results show that the hydrogel exhibits significant antioxidant and tyrosinase inhibition dual efficacy. Through the DPPH free radical scavenging experiment, the clearance efficiency reaches (89.80±0.24)%, which indicates that it has excellent antioxidant capacity; at the same time, the inhibition rate of (78.41±1.18)% is measured in the tyrosinase inhibition experiment, which shows good whitening activity potential.

[0100] 2.7 In vitro transdermal experiment results

[0101] The in vitro transdermal absorption kinetics curve is drawn with the sampling time as the abscissa and the DPPH free radical clearance rate as the ordinate. The results show that the DPPH free radical clearance rate is continuously stable at more than 50% within 6h, as shown in Figure 4 .

[0102] In summary, the present application develops a green hydrogel with whitening and antioxidant functions based on the basic medicinal pair of Bletilla striata and Angelica dahurica, and the whitening effect is significant when Bletilla striata and Angelica dahurica are used in combination. The present application determines the optimal ratio of traditional Chinese medicinal materials by detecting the antioxidant properties and the ability to inhibit tyrosinase activity of the alcohol extract of traditional Chinese medicinal materials; the effects of ultrasonic time, solid-liquid ratio, ultrasonic power, ultrasonic frequency and other factors on the antioxidant properties of the alcohol extract of traditional Chinese medicinal materials are investigated by single factor experiment, and then the alcohol extraction process of the medicinal liquid is optimized by means of response surface Box-Benhnken design; then, the extracted medicinal liquid is combined with excipients to prepare a hydrogel, and the optimal proportion of excipients is determined by viscosity detection and sensory evaluation to complete the preparation of the hydrogel; finally, the efficacy of the hydrogel is improved through transdermal experiment and physical and chemical property detection. Therefore, the present application develops a hydrogel with significant whitening effect and stable appearance, which provides reliable experimental basis and new ideas for the field of traditional Chinese medicine whitening.

[0103] Although the specific embodiments of the present application are described above, those skilled in the art should understand that the specific examples described are only illustrative, and are not intended to limit the scope of the present application, and equivalent modifications and changes made by those skilled in the art in accordance with the spirit of the present application should be covered within the scope of the claims of the present application.

Claims

1. An anti-oxidative whitening traditional Chinese medicine hydrogel composition, characterized in that: The traditional Chinese medicine extract is obtained by extracting medicinal material raw materials in the following proportions by weight: 5-15 parts of white bletilla, 1.5-10 parts of white peony root, 5-15 parts of ramie root, 3-10 parts of cortex moutan, and 1.5-10 parts of purple flower ground ivy. ​ 2. The anti-oxidative and whitening traditional Chinese medicine hydrogel composition according to claim 1, characterized in that: The traditional Chinese medicine extract is obtained by ultrasonic extraction of medicinal material raw materials with an ethanol solvent.

3. The anti-oxidative and whitening traditional Chinese medicine hydrogel composition according to claim 1, characterized in that: The traditional Chinese medicine extract is obtained by ultrasonic extraction of medicinal material raw materials in the following proportions by weight with an ethanol solvent: 7.5 parts of white bletilla, 2.5 parts of white peony root, 7.5 parts of ramie root, 5 parts of cortex moutan, and 2.5 parts of purple flower ground ivy.

4. The anti-oxidative and whitening traditional Chinese medicine hydrogel composition according to claim 1, characterized in that: The composition further comprises a hydrogel auxiliary material, and the weight percentage of each component in the composition is: 10-30% of the traditional Chinese medicine extract, 10-30% of the hydrogel auxiliary material, and the balance being deionized water.

5. The anti-oxidative and whitening traditional Chinese medicine hydrogel composition according to claim 4, characterized in that: The hydrogel auxiliary material comprises carbomer, propylene glycol, triethanolamine, nicotinamide, borneol, nipagin methyl ester, cochineal solution, and gardenia essential oil; and the weight percentage of each component in the composition is: 0.5% of carbomer, 5% of propylene glycol, 5% of triethanolamine, 0.5% of nicotinamide, 0.05% of borneol, 0.01% of nipagin methyl ester, 0.04% of cochineal, 0.0125% of gardenia essential oil, 10% of the traditional Chinese medicine extract, and the balance being deionized water.

6. The anti-oxidative and whitening traditional Chinese medicine hydrogel composition according to claim 2, characterized in that: The preparation conditions of the traditional Chinese medicine extract are: an ethanol concentration of 30-60%, a solid-liquid ratio of 1:8-14 g / mL, an ultrasonic time of 30-60 min, an extraction number of 2-4 times, and an ultrasonic power of 100-300 W.

7. The anti-oxidative and whitening traditional Chinese medicine hydrogel composition according to claim 6, characterized in that: The preparation conditions of the traditional Chinese medicine extract are: an ethanol concentration of 40%, a solid-liquid ratio of 1:12 g / mL, an ultrasonic time of 30 min, an extraction number of 3 times, and an ultrasonic power of 280 W.

8. A method for preparing an anti-oxidative whitening traditional Chinese medicine hydrogel composition, characterized in that: The composition is the composition of any one of claims 1-4, and the preparation method comprises the following steps: (a) crushing white bletilla, white peony root, ramie root, cortex moutan, and purple flower ground ivy through a 100-mesh sieve; (b) adding an ethanol solvent, and performing ultrasonic extraction under the conditions of an ethanol concentration of 30-60%, a solid-liquid ratio of 1:8-14 g / mL, an ultrasonic time of 30-60 min, an extraction number of 2-4 times, and an ultrasonic power of 100-300 W; (c) centrifuging to obtain supernatant, and concentrating and constant-volumeing the supernatant to 10 mL to obtain a traditional Chinese medicine extract; (d) swelling carbomer with water, and sequentially adding propylene glycol, triethanolamine, nicotinamide, borneol, nipagin methyl ester, cochineal solution, and gardenia essential oil; (e) uniformly mixing the traditional Chinese medicine extract with the mixture of step (d), and adding water to a target weight to obtain a hydrogel.

9. The method for preparing an antioxidant and whitening herbal hydrogel composition according to claim 8, characterized in that: The preparation conditions of the traditional Chinese medicine extract in step (b) are: an ethanol concentration of 40%, a solid-liquid ratio of 1:12 g / mL, an ultrasonic time of 30 min, an extraction number of 3 times, and an ultrasonic power of 280 W.

10. The method for preparing an antioxidant and whitening herbal hydrogel composition according to claim 8, characterized in that: The mixing in step (e) is performed at room temperature, and the stirring speed is 500-1000 r / min.

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