A pet stress-relieving agent

Abstract

The present application belongs to the technical field of pet care, and provides a pet stress reliever which is simple, direct, long-term in use and harmless to pets, and comprises vitamin B group, catmint, benzalkonium chloride, rapid stress reliever and natural stress reliever, wherein the natural stress reliever comprises carboxymethyl chitosan, lavender extract and spina date seed, and the unexpected synergistic effect is generated under a specific ratio, so that the sleep quality of pets, especially cats and dogs, is improved, and the stress reaction when entering a strange environment or taking a bath is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pet care, in particular to a pet stress reliever. BACKGROUND

[0002] The stress of pets mainly comes from sudden changes in living environment, diseases, medical stress, food stress, unsatisfied curiosity, competition for love, etc. The rapid development of pet clinical medicine plays an important role in promoting the health and life extension of pets. We are pleased that pet medical treatment is becoming more and more humanized, especially in pet anesthesia and surgical operation, pet pain management, more and more attention is paid to their physical feelings, but in these aspects we are still lagging behind, or to say that in most pet hospitals, it is not very good, which will have an adverse effect on the recovery of pet diseases and will also leave a psychological shadow on pets. Similarly, in life, the personality and habits of pet owners often affect their pets, but there are also many times when the obedience of pets is not necessarily willing, and if their behavior or psychology is not understood or ignored, it may cause some chronic harm to their psychology and body, including the long-term unmet needs of pets, the jealousy of pets, etc. For pets, it is also a chronic stress. Under the continuous chronic stress, the neuroendocrine system in the body will play a long-term role, and the hormone level of the body will continue to be in a high state of readiness, which will harm the related organs in the body and will cause immunosuppression, thereby affecting the life of pets.

[0003] There are many acute stresses on pets, such as physical trauma, chemical trauma, injection of vaccines, etc. which can make the body complete a stress resistance. Active treatment, soothing during treatment and post-treatment care are important methods to reduce stress damage. However, chronic stress is relatively wide, in addition to living environment stress, food stress and psychological stress of pets cannot be ignored. In the research of economic animals, animal welfare is highly valued, and people know how to improve animal welfare and reduce stress to improve the feed-meat ratio and improve the quality of products. Pets can ignore the results of these problems, but chronic stress will accelerate the organ failure and even cause acute damage.

[0004] For example, when pets are purchased from a different place and transported, they will inevitably have some stress reactions when they arrive in a new environment, or when they are fed with different tastes and different brands of food, they will also have some stress reactions. At this time, if the pet-specific butyric acid clostridium complex probiotic bacteria are used to balance the intestinal flora, increase beneficial bacteria and eliminate harmful bacteria, in a state of microecological balance, the resistance of pets is enhanced to resist stress reactions, then many diseases can be reduced.

[0005] As living standards improve, people are treating their pets with increasing care, and different people have different responsibilities. For pet owners and anyone working in the pet industry, learning about pet psychology and behavior is essential. Understanding pets from multiple perspectives is crucial to providing support based on their psychological and physiological needs and improving their quality of life.

[0006] With the continuous expansion of the pet market and the increasing number of pets, the frequency of stress has also risen sharply. However, learning pet psychology and behavior presents a certain barrier for ordinary pet owners. On the other hand, the issue of stray cats and dogs is also being studied more extensively, and stress in stray cats and dogs is more likely to cause harm. Therefore, there is an urgent need for a simpler, more direct, and long-term solution or treatment to address pet stress. Summary of the Invention

[0007] The purpose of this invention is to provide a pet stress reliever that is simple, direct, and can be used long-term without harming pets.

[0008] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0009] A pet stress reliever, characterized by comprising B vitamins, catnip, benzalkonium chloride, a rapid-acting calming agent, a natural calming agent, and distilled water. The pet stress reliever can be formulated as a spray, or as a volatile liquid or solid form.

[0010] B vitamins participate in antioxidant reactions, protecting cells from free radical damage. They also maintain the health of the skin, eyes, and oral mucosa, and are involved in the production of mood-regulating chemicals such as serotonin and dopamine.

[0011] The main active ingredient in catnip is nepetalactone, a volatile oil compound that stimulates a cat's olfactory system. The ester mimics a cat's pheromones, triggering a pleasurable response in the brain, but it is neither addictive nor harmful.

[0012] Benzalkonium chloride is a cationic surfactant mainly used for cleaning and disinfection. Its disinfection mechanism is mainly reflected in the following aspects: 1. Altering cell membrane permeability: Benzalkonium chloride has both hydrophilic and lipophilic groups. The bacterial cell membrane is composed of a phospholipid bilayer. The lipophilic group can interact with lipids in the cell membrane and insert into the cell membrane, while the hydrophilic group interacts with water molecules. This interaction disrupts the integrity of the cell membrane, altering its permeability, causing substances such as proteins and nucleic acids inside the bacterial cell to leak out, leading to bacterial death. 2. Protein denaturation: Benzalkonium chloride can bind to proteins on the bacterial surface, interfering with the normal structure and function of proteins, causing protein denaturation. Proteins are an important material basis for bacterial life activities. Once denatured, the physiological processes of bacterial metabolism, growth, and reproduction cannot proceed normally, thus losing their activity. 3. Inhibiting enzyme activity: Bacterial metabolic processes depend on the participation of various enzymes. Benzalkonium chloride can bind to enzymes within bacteria, inhibiting enzyme activity, blocking bacterial metabolic pathways, and ultimately achieving the purpose of sterilization and disinfection. The invention was unexpectedly found to also have a good effect on relieving stress in pets, so it was chosen to be used.

[0013] Preferred ingredients include B vitamins, catnip, benzalkonium chloride, rapid soothing agents, natural soothing agents, and distilled water mixed in a mass ratio of 0.3~0.7:0.3~0.7:0.1~0.5:0.1~0.4:5:92~94.

[0014] Preferably, the mixture includes B vitamins, catnip, benzalkonium chloride, rapid soothing agent, natural soothing agent, and distilled water in a mass ratio of 0.5:0.5:0.3:0.2:5:93.5.

[0015] Preferably, the natural soothing agent comprises carboxymethyl chitosan, lavender extract, jujube seed, and distilled water mixed in a mass ratio of 1~2:2~3:2~3:92~95.

[0016] The addition of natural soothing agents can effectively reduce the use of chemical agents. It is a solution that uses natural extracts to regulate the stress state of pets, and can further enable the obtained pet stress soothing agents to be used for a long time and are safe and non-toxic.

[0017] Carboxymethyl chitosan (CMC) can promote the growth of fibroblasts and epidermal keratinocytes, and CMC with a molecular weight of around 3 kDa has a similar effect on promoting the growth of both cells as bFGF and EGF. CMC can effectively accelerate wound healing by promoting fibroblast proliferation and enhancing macrophage phagocytosis. CMC also accelerates wound healing by increasing TGF-β1 and IL-6 levels. Furthermore, CMC regulates collagen secretion by stimulating IL-8 in fibroblasts, TNF-α in macrophages, and MMP-1 in damaged skin, thus helping to reduce scar formation. These studies reveal the potential mechanisms by which CMC acts on wound healing.

[0018] Lavender extract has the effect of relieving anxiety and insomnia, and studies have shown that it has analgesic and antibacterial potential (such as inhibiting Staphylococcus aureus).

[0019] Sour jujube seed, also known as jujube kernel, sour jujube pit, or wild jujube seed, is made from the mature fruit of the sour jujube tree (Rhamnaceae family), after removing the pulp and shell, collecting the seeds, and drying them. It has a sweet and sour taste and is neutral in nature. It enters the liver, gallbladder, and heart meridians. It nourishes the liver and heart, calms the mind, and reduces sweating.

[0020] Preferably, the natural soothing agent comprises carboxymethyl chitosan, lavender extract, jujube seed, and distilled water mixed in a mass ratio of 1:2:2:95.

[0021] Preferably, the rapid soothing agent comprises 5-hydroxytryptamine, cannabidiol, and solvent mixed in a mass ratio of 1~2: 1~2: 96~98.

[0022] The addition of rapid-acting soothing agents allows for quick relief of bodily pain, including headaches, muscle aches, and arthritis. They improve overall health through analgesic, pain-relieving, and anti-inflammatory effects. Rapid-acting soothing agents can help reduce anxiety and stress, promoting relaxation. In the cosmetics industry, they can soothe the skin, relieving pain and discomfort. They can also protect the skin and prevent allergic reactions. Some rapid-acting soothing agents can be used to alleviate mood and anxiety in pets.

[0023] Among them, serotonin (5-hydroxytryptamine) is known as the "happy hormone" and plays an important role in mood stability, anti-anxiety, and happiness.

[0024] CBD (cannabidiol) can inhibit the release and activity of some key mediators in the inflammatory response, and can be used to alleviate symptoms of various inflammation-related diseases, such as inflammatory bowel disease and skin diseases. CBD acts on the neurotransmitter system in the brain, such as regulating the levels of neurotransmitters like serotonin, which helps alleviate anxiety and depression and improve related psychological states. Furthermore, CBD has a certain protective effect on the nervous system and may help prevent and improve some neurodegenerative diseases.

[0025] Preferably, the rapid soothing agent comprises 5-hydroxytryptamine, cannabidiol, and a solvent mixed in a mass ratio of 1:1:98.

[0026] Preferably, the solvent includes one or more of water and alcohol.

[0027] Preferably, the benzalkonium chloride comprises the following structural formula:

[0028] .

[0029] An application of the aforementioned pet stress reliever for pet care.

[0030] Compared with the prior art, implementing the present invention has the following beneficial effects:

[0031] This invention provides a simple, direct, and long-term pet stress reliever that does not harm pets. It includes B vitamins, catnip, benzalkonium chloride, a rapid-acting soothing agent, and a natural soothing agent. The natural soothing agent includes carboxymethyl chitosan, lavender extract, and jujube seed. In a specific ratio, these ingredients produce an unexpected synergistic effect, which can improve the sleep quality of pets, especially cats and dogs, and reduce stress reactions when entering unfamiliar environments or during bathing. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to specific embodiments, but the implementation of the present invention is not limited thereto.

[0033] Unless otherwise specified, the raw materials, reagents or apparatus used in the following examples or comparative examples are available from conventional commercial sources or can be obtained by existing known methods.

[0034] Example 1

[0035] A pet stress reliever is a mixture of the following components in parts by weight: 0.5% B vitamins, 0.5% catnip, 0.3% benzalkonium chloride, 0.2% rapid calming agent, 5% natural calming agent, and 93.5% distilled water.

[0036] The rapid soothing agent is a mixture of the following components in parts by weight: 1% serotonin, 1% cannabidiol, and 98% solvent (water).

[0037] The natural soothing agent is a mixture of the following components in parts by weight: 1% carboxymethyl chitosan, 2% lavender extract, 2% jujube seed extract, and 95% distilled water.

[0038] Example 2

[0039] A pet stress reliever is a mixture of the following components in parts by weight: 0.3% B vitamins, 0.3% catnip, 0.2% benzalkonium chloride, 0.2% rapid calming agent, 5% natural calming agent, and 94% distilled water.

[0040] The rapid-acting soothing agent is a mixture of the following components in parts by weight: 1% serotonin, 2% cannabidiol, and 97% solvent (water).

[0041] The natural soothing agent is a mixture of the following components in parts by weight: 2% carboxymethyl chitosan, 3% lavender extract, 3% jujube seed extract, and 92% distilled water.

[0042] Example 3

[0043] A pet stress reliever is a mixture of the following components in parts by weight: 0.7% B vitamins, 0.7% catnip, 0.5% benzalkonium chloride, 0.4% rapid calming agent, 5% natural calming agent, and 92.7% distilled water.

[0044] The rapid-acting soothing agent is a mixture of the following components in parts by weight: 2% serotonin, 2% cannabidiol, and 96% solvent (alcohol).

[0045] The natural soothing agent is a mixture of the following components in parts by weight: 2% carboxymethyl chitosan, 2% lavender extract, 2% jujube seed extract, and 94% distilled water.

[0046] Comparative Example 1

[0047] A pet stress reliever, with the same formulation ratio as in Example 1, except that benzalkonium chloride is not added to the formulation components in this comparative example.

[0048] Comparative Example 2

[0049] A pet stress reliever, with the same formulation ratio as in Example 1, except that in this comparative example, the natural reliever is mixed according to the following parts by weight: 2% lavender extract, 2% jujube seed, and 96% distilled water.

[0050] Comparative Example 3

[0051] A pet stress reliever, with the same formulation ratio as in Example 1, except that in this comparative example, the natural reliever is mixed according to the following mass parts: 1% carboxymethyl chitosan, 2% jujube seed, and 97% distilled water.

[0052] Comparative Example 4

[0053] A pet stress reliever, with the same formulation ratio as in Example 1, except that in this comparative example, the natural reliever is mixed according to the following parts by weight: 1% carboxymethyl chitosan, 2% lavender extract, and 97% distilled water.

[0054] Comparative Example 5

[0055] A pet stress reliever, with the same formulation ratio as in Example 1, except that in this comparative example, the natural reliever is mixed according to the following components in parts by weight: 1% carboxymethyl chitosan, 1% lavender extract, 1% jujube seed, and 97% distilled water.

[0056] Comparative Example 6

[0057] A pet stress reliever, with the same formulation ratio as in Example 1, except that in this comparative example, the natural reliever is mixed according to the following components by weight: 2% carboxymethyl chitosan, 1% lavender extract, 1% jujube seed, and 96% distilled water.

[0058] Comparative Example 7

[0059] A pet stress reliever is a mixture of the following components in parts by weight: 0.5% B vitamins, 0.5% catnip, 0.3% benzalkonium chloride, 0.2% rapid calming agent, 6% natural calming agent, and 92.5% distilled water.

[0060] The rapid soothing agent is a mixture of the following components in parts by weight: 1% serotonin, 1% cannabidiol, and 98% solvent (water).

[0061] The natural soothing agent is a mixture of the following components in parts by weight: 1% carboxymethyl chitosan, 2% lavender extract, 2% jujube seed extract, and 95% distilled water.

[0062] Comparative Example 8

[0063] A pet stress reliever is a mixture of the following components in parts by weight: 0.5% B vitamins, 0.5% catnip, 0.3% benzalkonium chloride, 0.2% rapid calming agent, 4% natural calming agent, and 94.5% distilled water.

[0064] The rapid soothing agent is a mixture of the following components in parts by weight: 1% serotonin, 1% cannabidiol, and 98% solvent (water).

[0065] The natural soothing agent is a mixture of the following components in parts by weight: 1% carboxymethyl chitosan, 2% lavender extract, 2% jujube seed extract, and 95% distilled water.

[0066] Example of effect 1

[0067] Experimental product: Pet stress reliever, with the formulation shown in Examples 1-3 and Comparative Examples 1-9.

[0068] Experimental subjects: 60 sound-sensitive cats of the same age (5 cats per group, repeated for verification).

[0069] Experimental method: Spray directly onto the pet and press the nozzle 2-3 times (approximately 0.2 mL).

[0070] Experimental scenario: continuous noise stimulation (85dB).

[0071] The experimental results are shown in Table 1:

[0072] Table 1

[0073]

[0074] As shown in Table 1, compared with the examples, Comparative Example 1, lacking benzalkonium chloride, exhibited a significant decrease in stability, and its onset time, duration, and behavioral improvement effects were all somewhat diminished. This indicates that benzalkonium chloride not only has good preservative effects but also unexpectedly enhances stress relief when combined with natural soothing agents. Comparative Example 2, lacking carboxymethyl chitosan in its natural soothing agent, showed a significantly slower onset time, a significantly shorter duration, and skin dryness, with a somewhat diminished behavioral improvement effect. This indicates that carboxymethyl chitosan not only has good moisturizing effects but also unexpectedly provides auxiliary stress relief. Comparative Example 3, lacking lavender extract in its natural soothing agent, showed a significantly slower onset time, a significantly shorter duration, and a somewhat diminished behavioral improvement effect. This indicates that lavender has an unexpected auxiliary stress relief effect. Comparative Example 4, lacking jujube seed in its natural soothing agent, showed a significantly shorter duration, a somewhat diminished onset time and behavioral improvement effect, and mild irritation. This indicates that jujube seed... Jujube seed has a certain effect in alleviating irritation and has an unexpected auxiliary stress-relieving effect. In Comparative Example 5, due to the low proportion of lavender extract and jujube seed in the natural soothing agent, the onset time, duration, and behavioral improvement effect all showed significant deterioration, indicating that the low dosage of lavender extract and jujube seed cannot effectively assist in stress relief. In Comparative Example 6, due to the high proportion of carboxymethyl chitosan in the natural soothing agent, the onset time, duration, and behavioral improvement effect all showed a certain degree of deterioration, indicating that carboxymethyl chitosan and lavender seed have a certain degree of deterioration. Lavender extract and jujube seed extract need to be used in a reasonable ratio to effectively assist in stress relief. In Comparative Example 7, due to the increased dosage of the natural soothing agent, mild drowsiness occurred, and there was no significant improvement in onset time, duration, or behavioral improvement, indicating that the dosage of the natural soothing agent must be controlled within a reasonable range. In Comparative Example 8, due to the decreased dosage of the natural soothing agent, the onset time, duration, and behavioral improvement all showed significant deterioration, indicating that too low a dosage of the natural soothing agent cannot effectively assist in stress relief. Only the formulations of the three examples of this invention have good soothing effects, with rapid onset, long duration, and no irritation. In particular, the formulation of Example 1 has the shortest onset time, the longest duration, and the best behavioral improvement effect, and should be considered the preferred choice.

[0075] Example 2

[0076] Golden Retriever stress in a car

[0077] Experimental product: Pet stress reliever, tested using the formulations shown in Example 1, Comparative Example 1, and Comparative Example 9.

[0078] Experimental subjects: Three golden retrievers of the same age, each placed in a different airline crate.

[0079] Experimental method: Spray on the areas where the pet often stays (bed, inner wall of the pet carrier), press the nozzle 2-3 times (about 0.2 mL).

[0080] Experimental scenario: Vehicle transportation.

[0081] The experimental results are shown in Table 2:

[0082] Table 2

[0083]

[0084] As shown in Table 2, Example 1, using the formula of this invention, can quickly eliminate stress and restore calm in pets. Comparative Example 1, however, showed a longer recovery time and poorer recovery effect. Comparative Example 9 failed to restore calm in the pet during this experiment.

[0085] Example 3

[0086] Experimental product: Pet stress reliever, tested using the formulation shown in Example 1.

[0087] Experimental subject: Ragdoll cat "Milo" (2 years old).

[0088] Experimental method: Spray the inside of the cat carrier.

[0089] Experimental scenario: waiting area at a pet hospital.

[0090] Experimental results:

[0091] Before use: Violent trembling, attempting to hide deep inside the cat carrier (persistent anxiety >10 minutes)

[0092] After use: The shaking stopped 5 minutes after spraying. Start observing the environment. No sound was made throughout the process.

[0093] Example of effect 4

[0094] Experimental product: Pet stress reliever, tested using the formulation shown in Example 1.

[0095] Experimental subject: Golden Retriever "Max" (3 years old).

[0096] Experimental method: Spray around the dog kennel.

[0097] Experimental scenario: Thunderstorm weather.

[0098] Experimental results:

[0099] Before use: shortness of breath, hiding everywhere (heart rate > 140 bpm).

[0100] After use: Spray for 15 minutes until the heart rate drops to 98 bpm, then lie down and rest.

[0101] Example 5

[0102] Additional security testing.

[0103] Skin irritation test: When sprayed directly onto pet dogs, 0 / 50 cases showed redness or itching (according to international standard ISO10993-10).

[0104] Licking test: 50 pet dogs were allowed to roam in the sprayed area for 24 hours and showed no signs of vomiting or diarrhea (meets FDA pet product safety standards).

[0105] The above-disclosed embodiments are merely preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. Therefore, any equivalent variations made in accordance with the claims of the present invention are still within the scope of the present invention.

Claims

1. A pet stress reliever, characterized in that, It is prepared by mixing B vitamins, catnip, benzalkonium chloride, rapid soothing agent, natural soothing agent, and distilled water in a mass ratio of 0.3~0.7:0.3~0.7:0.1~0.5:0.1~0.4:5:92~94; the natural soothing agent is prepared by mixing carboxymethyl chitosan, lavender extract, jujube seed, and distilled water in a mass ratio of 1~2:2~3:2~3:92~95; the rapid soothing agent is prepared by mixing 5-hydroxytryptamine, cannabidiol, and solvent in a mass ratio of 1~2:1~2:96~98; the solvent is one or more of water and alcohol.

2. The pet stress reliever as described in claim 1, characterized in that, It is made by mixing B vitamins, catnip, benzalkonium chloride, rapid soothing agent, natural soothing agent, and distilled water in a mass ratio of 0.5:0.5:0.3:0.2:5:93.

5.

3. The pet stress reliever as described in claim 1, characterized in that, The natural soothing agent is made by mixing carboxymethyl chitosan, lavender extract, jujube seed, and distilled water in a mass ratio of 1:2:2:

95.

4. The pet stress reliever as described in claim 1, characterized in that, The rapid-acting soothing agent is prepared by mixing 5-hydroxytryptamine, cannabidiol, and the solvent in a mass ratio of 1:1:

98.

5. The pet stress reliever as described in claim 1, characterized in that, The benzalkonium chloride has the following structural formula: 。

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