Traditional Chinese medicine composition for treating female tachyarrhythmia and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating female tachyarrhythmia and application thereof, and the traditional Chinese medicine composition comprises the following components in parts by weight: 3-4 parts of rose, 5-8 parts of salvia miltiorrhiza, 3-4 parts of leonurus, 1.5-2.5 parts of coptis chinensis, 2-3 parts of rhizoma nardostachyos and 5-8 parts of radix rehmanniae recen. The rose is used as a main medicine, the aromatic characteristic of the rose can relieve liver qi stagnation and relieve restlessness caused by emotional pressure of women, the rhizoma nardostachyos is matched to assist in regulating qi and relieving depression, and the rose and the rhizoma nardostachyos cooperate to regulate qi activity and improve anxiety, dysphoria and other mood problems. Coptis chinensis serves as a heat clearing core, directly clears heart fire, inhibits palpitation caused by liver depression transforming into heat, and has the compatibility characteristics of soothing liver without assisting heat and clearing heat without stagnation with roses. The radix rehmanniae recen nourishes yin and blood, supplements liver blood loss, prevents liver soothing medicine from being consumed to injure yin blood, forms closed-loop regulation of liver soothing, heat clearing and blood nourishing, and reduces inducements of tachyarrhythmia from the source.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for treating female tachyarrhythmias and its application. Background Technology

[0002] Frequent premature ventricular contractions (PVCs) and atrial fibrillation (AF) are common cardiovascular diseases in women. Due to hormonal fluctuations and socio-psychological stress, the incidence rate is significantly higher in women than in men. While medication and catheter ablation are important modern medical treatments for frequent PVCs, they cannot currently resolve all clinical problems, in addition to actively correcting the underlying cause. Long-term medication use can easily lead to serious side effects such as thyroid dysfunction and pulmonary fibrosis, while catheter ablation has limitations in success rate, complication risks, and high costs. Female patients, especially those of childbearing age, often present with clinical features of non-structural heart disease in cases of tachyarrhythmias. For those who fear the potential side effects of modern medical drugs and are concerned about the high cost of catheter ablation, traditional medicine becomes an important treatment option. While traditional Chinese medicine has unique advantages in regulating autonomic nerve function and improving myocardial microcirculation, existing treatment plans are mostly based on the general principle of "tonifying qi and nourishing yin," lacking targeted intervention for the dynamic pathogenesis chain of "liver stagnation and blood deficiency - central nervous system dysfunction - heart fire disturbance" in women. This results in unstable efficacy and unclear mechanisms of action, making it difficult to complement modern medicine.

[0003] The pathological mechanisms of cardiac arrhythmias in women are significantly unique: cyclical changes in estrogen can affect myocardial electrophysiological stability; socio-psychological stress exacerbates cardiac automaticity abnormalities through sympathetic nerve activation; and chronic blood deficiency caused by pregnancy, childbirth, and lactation further aggravates cardiac malnourishment. Current TCM and Western medicine treatment systems have not systematically integrated the multiple pathogenic links of "reproductive depletion - emotional imbalance - microcirculatory disturbance." Traditional prescriptions often remain at the level of "invigorating blood and calming the mind," failing to construct a synergistic network of "soothing the liver and relieving depression - nourishing blood and clearing the heart - regulating the mind and calming the spirit." This results in theoretical gaps and practical blind spots in the intervention of rapid cardiac arrhythmias in women.

[0004] To address the aforementioned challenges, this invention, grounded in classical Traditional Chinese Medicine (TCM) theory, innovatively proposes the treatment principle of "relieving depression and calming the mind." Breaking away from traditional prescription approaches, it establishes a multi-target regulatory mechanism by carefully selecting TCM herbs that soothe the liver, relieve depression, cool the blood, and calm the mind. This approach not only systematically elucidates the pathogenesis of "liver blood deficiency leading to dysfunction of the central nervous system and disturbance of the mind by internal heat," but also reveals, through modern pharmacological research, the molecular mechanisms by which it regulates ion channels and inhibits triggering activities. This provides a TCM solution with both theoretical innovation and practical value for the precise treatment of tachyarrhythmias in women. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine composition for treating female tachyarrhythmias and its application. It is composed of rose, salvia miltiorrhiza, motherwort, coptis chinensis, nardostachys chinensis and rehmannia glutinosa. Through the synergistic effects of soothing the liver and relieving depression, cooling the blood and calming the mind, and promoting blood circulation and nourishing the blood, it can improve palpitation symptoms and reduce premature ventricular contractions and atrial fibrillation. It takes into account the physiological and pathological characteristics of women and has significant curative effects.

[0006] To achieve the above-mentioned technical objectives and effects, the present invention is implemented through the following technical solution:

[0007] A traditional Chinese medicine composition for treating tachyarrhythmias in women, comprising rose, salvia miltiorrhiza, motherwort, coptis chinensis, nard, and rehmannia glutinosa.

[0008] Furthermore, the weight ratio of the traditional Chinese medicine composition is as follows: 2-5 parts of rose, 3-10 parts of salvia miltiorrhiza, 2-5 parts of motherwort, 1-3 parts of coptis chinensis, 1-4 parts of nardostachys jatamansi, and 3-10 parts of rehmannia glutinosa.

[0009] Furthermore, the weight ratio of the traditional Chinese medicine composition is as follows: 3-4 parts of rose petals, 5-8 parts of salvia miltiorrhiza, 3-4 parts of motherwort, 1.5-2.5 parts of coptis chinensis, 2-3 parts of nardostachys jatamansi, and 5-8 parts of rehmannia glutinosa.

[0010] Furthermore, the dosage form of the composition is a decoction, granules, pills, capsules, or oral liquid preparation.

[0011] On the other hand, the present invention proposes the application of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating frequent premature ventricular contractions in women of childbearing age, wherein the drug has the effect of reducing the number of premature ventricular contractions and improving palpitation symptoms.

[0012] On the other hand, the present invention proposes the application of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating atrial fibrillation in women, wherein the drug can reduce the number of rapid arrhythmic events in 24 hours.

[0013] Rose: Properties: Sweet; slightly bitter; warm; Liver meridian; Spleen meridian. Indications: Regulates Qi and relieves depression, harmonizes blood and dispels blood stasis. Treats liver and stomach Qi pain, acute and chronic wind-dampness, hematemesis, hemoptysis, irregular menstruation, leukorrhea, dysentery, mastitis, and boils.

[0014] Salvia miltiorrhiza: Properties: Bitter, slightly warm; enters the heart and liver meridians. Indications: Removes blood stasis and relieves pain, invigorates blood circulation and regulates menstruation, clears the heart and relieves irritability. Treats angina pectoris, irregular menstruation, dysmenorrhea, amenorrhea, metrorrhagia, leukorrhea, abdominal masses, accumulations, abdominal pain due to blood stasis, joint pain, palpitations, insomnia, and malignant sores and carbuncles.

[0015] Motherwort: Properties: Bitter, pungent, slightly cold; enters the liver and pericardium meridians. Indications: Activates blood circulation and regulates menstruation, removes blood stasis, promotes diuresis and reduces swelling. Treats irregular menstruation, threatened abortion, difficult labor, retained placenta, postpartum hemorrhage, abdominal pain due to blood stasis, metrorrhagia, hematuria, hematochezia, carbuncles and sores.

[0016] Coptis chinensis: Properties: Bitter; Cold; Meridians: Heart, Liver, Stomach, Large Intestine. Indications: Clears heat, dries dampness, detoxifies, kills parasites. Treats epidemic febrile diseases, typhoid fever, fever with restlessness, abdominal distension and vomiting, bacillary dysentery, diarrhea with abdominal pain, pulmonary tuberculosis, vomiting, nosebleeds, hematochezia, diabetes, malnutrition, ascariasis, whooping cough, sore throat, conjunctivitis, canker sores, carbuncles, eczema, burns.

[0017] Nardostachys jatamansi: Taste: pungent; sweet; nature: warm; enters the spleen and stomach meridians. Indications: Regulates qi and relieves pain, invigorates the spleen and strengthens the stomach. Treats stomach pain, abdominal distension, headache, hysteria, beriberi, and loss of appetite.

[0018] Rehmannia glutinosa: Taste and nature: sweet; bitter; slightly cold; enters the heart, liver, and kidney meridians. Indications: nourishes yin and clears heat, cools blood and replenishes blood. Used for feverish thirst, internal heat and thirst, steaming bone fever, febrile diseases with rashes, hematemesis, metrorrhagia, hematuria, hematochezia caused by blood heat, anemia and chlorosis, dizziness and palpitations, and amenorrhea due to insufficient blood.

[0019] The beneficial effects of this invention are:

[0020] This invention uses rose as the main ingredient, whose aromatic properties can relieve liver qi stagnation and alleviate restlessness caused by emotional stress in women. It is combined with Nardostachys jatamansi to further regulate qi and relieve stagnation; the two ingredients work synergistically to regulate qi and improve emotional problems such as anxiety and irritability. Coptis chinensis, as the core ingredient for clearing heat, directly clears heart fire and inhibits palpitations and anxiety caused by liver qi stagnation transforming into heat, forming a combination with rose that "soothes the liver without promoting heat, and clears heat without causing stagnation." Rehmannia glutinosa nourishes yin and blood, replenishing liver blood loss and avoiding the depletion of yin and blood by liver-soothing herbs, forming a closed-loop regulation of "soothing the liver - clearing heat - nourishing blood," reducing the root causes of rapid arrhythmias.

[0021] Danshen (Salvia miltiorrhiza) and Leonurus japonicus (Motherwort) are specifically designed to invigorate blood circulation and remove blood stasis. Danshen improves blood vessel obstruction and promotes myocardial microcirculation, while Leonurus japonicus focuses on regulating menstruation and unblocking meridians, addressing the issue of blood viscosity caused by physiological blood deficiency in women. Combined with the yin-nourishing properties of Rehmannia glutinosa, they both clear blood stasis and replenish insufficient yin and blood, avoiding the aggravation of blood deficiency by simply invigorating blood circulation. This combination of "invigorating blood without harming blood, and nourishing yin without leaving blood stasis" effectively repairs myocardial ischemia-reperfusion injury, reduces abnormal electrical activity caused by blood stasis or blood deficiency, and stabilizes cardiac rhythm.

[0022] This invention intervenes in arrhythmia at different levels through the synergistic effect of multiple drugs: rose petals and nard regulate the balance of the autonomic nervous system and reduce excessive sympathetic nerve excitation; coptis chinensis inhibits excessive heart fire and reduces abnormal discharge of myocardial cells; salvia miltiorrhiza and leonurus japonicus improve myocardial blood supply and enhance the heart's resistance to hypoxia; and rehmannia glutinosa nourishes yin fluid and stabilizes myocardial cell membrane potential. The entire formula addresses the triple regulation of "emotion-qi and blood-heart," relieving symptoms such as palpitations and chest tightness while improving the internal pathogenesis through soothing the liver, nourishing yin, and promoting blood circulation, thus achieving long-term therapeutic effects.

[0023] Of course, any product implementing this invention does not necessarily need to achieve all of the advantages described above at the same time. Detailed Implementation

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] Example 1

[0026] The traditional Chinese medicine composition for treating female tachyarrhythmias described in this embodiment is composed of rose, salvia miltiorrhiza, motherwort, coptis chinensis, nardostachys chinensis and rehmannia glutinosa.

[0027] In this embodiment, the weight ratio of the traditional Chinese medicine composition is as follows: 2-5 parts of rose, 3-10 parts of salvia miltiorrhiza, 2-5 parts of motherwort, 1-3 parts of coptis chinensis, 1-4 parts of nardostachys jatamansi, and 3-10 parts of rehmannia glutinosa.

[0028] Example 2

[0029] The traditional Chinese medicine composition for treating female tachyarrhythmias described in this embodiment is composed of rose, salvia miltiorrhiza, motherwort, coptis chinensis, nardostachys chinensis and rehmannia glutinosa.

[0030] In this embodiment, each dose of the traditional Chinese medicine composition includes: 2-5g of rose petals, 3-10g of salvia miltiorrhiza, 2-5g of motherwort, 1-3g of coptis chinensis, 1-4g of nardostachys chinensis, and 3-10g of rehmannia glutinosa; each dose contains 12-37g.

[0031] Furthermore, the dosage form of the composition is a decoction, granules, pills, capsules, or oral liquid preparation.

[0032] Example 3

[0033] Based on the treatment principle of "soothing the blood and qi and making it flow smoothly" in Suwen·Zhizhen Yaoda Lun, and combined with the academic thought of "when the qi and blood are in harmony, no disease will arise; once there is stagnation, all diseases will arise" in Danxi Xinfa, the method of relieving stagnation and cooling blood was created for the core pathogenesis of premature ejaculation in women: "stagnation fire scorching the collaterals and blood heat disturbing the mind". The empirical formula "Rose Heart-Clearing Drink" was also refined. Rose is the principal ingredient in this formula. *Ben Cao Zheng Yi* describes it as having "the strongest fragrance, clear and not turbid, harmonious and not harsh, soothing the liver and invigorating the stomach, promoting qi and blood circulation." *Ben Cao Zai Xin* states that it "soothes the stagnation of liver and gallbladder qi." Modern pharmacology confirms that its quercetin can regulate autonomic nerve tone. Salvia miltiorrhiza and Coptis chinensis are the assistant ingredients. *Fu Ren Ming Li Lun* states that "Salvia miltiorrhiza alone has the effects of four herbs, nourishing and generating blood, surpassing Angelica sinensis and Rehmannia glutinosa, regulating and astringing blood, comparable to peony root, dispelling blood stasis and promoting new blood production, with properties twice that of Ligusticum chuanxiong." *Ben Cao Bei Yao* states that Coptis chinensis "drains heart fire, calms the liver and cools the blood," a combination that subtly aligns with the *Shang Han Lun*. The formula follows the principle of "nourishing yin and reducing fire" in Huanglian Ejiao Decoction. Moutan bark and motherwort are used as adjuvants. The *Compendium of Materia Medica* states that Moutan bark "drains latent fire in the blood, reduces bone steaming without sweating, disperses blood stasis without leaving it, and treats epilepsy." The *Extended Meaning of Materia Medica* states that motherwort "promotes blood circulation and nourishes blood," which aligns with the *Complete Collection of Effective Prescriptions for Women*'s emphasis on "blood as the foundation for women" and also fits the pathological characteristics of modern microcirculatory disorders. Nardostachys jatamansi is used as the guiding herb. The *Compendium of Materia Medica* states that it "regulates vital energy and removes stagnant qi," and the *Kaibao Materia Medica* records that it "treats sudden pain in the heart and abdomen," and its valerone content has a clear antiarrhythmic effect. The entire formula follows the principle of "smoothing blood and qi and guiding stagnation" in the *Commentary on the Materia Medica*, inheriting the "cooling blood and calming the mind" principle of Baihe Dihuang Decoction in the *Essential Prescriptions of the Golden Chamber*, and incorporating the "clearing heat and transforming qi" effect of Qingying Decoction in the *Treatise on Warm Diseases*. This formula innovatively integrates the "Yueju Pill" method for relieving depression from "Medical Insights" with the "Qinghua Drink" method for cooling blood from "Jingyue Complete Works," forming a three-in-one treatment system of "soothing the liver and relieving depression, nourishing yin and cooling blood, and promoting blood circulation and calming the mind." It inherits the classic treatment principle of "relieving stagnation of wood and releasing stagnation of fire" from "Huangdi Neijing," highlighting the academic characteristics of classical formulary in "integrating theory, method, prescription and medicine, and referencing ancient and modern mechanisms."

[0034] Example 4

[0035] Case 1

[0036] Ms. Hu, 59 years old.

[0037] Chief complaint: Intermittent palpitations for 5 years. Patient

[0038] Intermittent palpitations, currently being managed with Wenxin granules and metoprolol, with slight improvement. Holter monitoring (June 6, 2022, no medication taken): sinus rhythm (total heartbeats, 112,005), frequent premature ventricular contractions (21,336).

[0039] Presenting symptoms include: occasional palpitations, usually short-tempered with dry and bitter mouth, usually anxious, weakness in the lower limbs, poor sleep with many dreams, preference for warm food, and normal bowel movements.

[0040] Physical examination: General condition is good, with no obvious edema in both lower extremities.

[0041] Past medical history: Denies coronary heart disease and diabetes.

[0042] Auxiliary examinations: None.

[0043] Tongue appearance: Red tongue with a slightly greasy white coating.

[0044] Pulse: wiry pulse.

[0045] Western medical diagnosis: Frequent premature ventricular contractions

[0046] Traditional Chinese Medicine name for this condition: palpitation

[0047] Traditional Chinese Medicine Syndrome: Liver Qi Stagnation Transforming into Fire, Heat Disturbing the Mind

[0048] Treatment: Soothe the liver and calm the mind, nourish blood and soothe the nerves.

[0049] Prescription: 6g rose petals, 15g salvia miltiorrhiza, 9g motherwort, 3g coptis chinensis, 6g nardostachys jatamansi, 15g rehmannia glutinosa, 28 doses.

[0050] A follow-up Holter monitor test one month later showed sinus rhythm (total heart rate: 81,332 beats) and frequent premature ventricular contractions (7,465 beats). The patient reported that palpitations and other discomforts had significantly decreased compared to before.

[0051] Case 2

[0052] He Wei, female, 53 years old

[0053] Chief complaint: Intermittent heart palpitations for six months.

[0054] Six months ago, I experienced heart palpitations, and a Holter monitor test revealed atrial fibrillation. I am currently taking sotalol 80mg twice daily.

[0055] Current symptoms include: occasional palpitations, easy irritability, dry and bitter mouth upon waking, good appetite and sleep, and normal bowel movements.

[0056] Auxiliary examinations: Holter monitoring: paroxysmal atrial fibrillation; echocardiography: mild mitral and tricuspid regurgitation.

[0057] Physical examination: General condition is good, with no obvious edema in both lower extremities.

[0058] Past medical history: Denies history of coronary heart disease, diabetes, hypertension, etc.

[0059] Auxiliary examinations: None.

[0060] Tongue appearance: Red tongue with white coating

[0061] Pulse: wiry pulse.

[0062] Western medical diagnosis: Paroxysmal atrial fibrillation

[0063] Traditional Chinese Medicine name for this condition: palpitation

[0064] Traditional Chinese Medicine Syndrome: Liver Qi Stagnation Transforming into Fire, Heat Disturbing the Mind

[0065] Treatment: Soothe the liver and calm the mind, nourish blood and soothe the nerves.

[0066] Prescription: 9g rose petals, 15g salvia miltiorrhiza, 12g motherwort, 6g coptis chinensis, 9g nardostachys jatamansi, 20g rehmannia glutinosa, 28 doses.

[0067] The patient reported significant improvement in symptoms such as palpitations, and no recurrence of atrial fibrillation occurred during the medication period after taking the medication and checking their pulse.

[0068] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A traditional Chinese medicine composition for treating tachyarrhythmia in women, characterized in that, Rose, Salvia miltiorrhiza, Motherwort, Coptis, Herba and Rehmannia.

2. The traditional Chinese medicine composition for treating tachyarrhythmia in women according to claim 1, characterized in that: The weight ratio of the traditional Chinese medicine composition is: rose 2-5 parts, Salvia miltiorrhiza 3-10 parts, Motherwort 2-5 parts, Coptis 1-3 parts, Herba 1-4 parts, and Rehmannia 3-10 parts.

3. The traditional Chinese medicine composition for treating tachyarrhythmia in women according to claim 1, characterized in that: The weight ratio of the traditional Chinese medicine composition is: rose 3-4 parts, Salvia miltiorrhiza 5-8 parts, Motherwort 3-4 parts, Coptis 1.5-2.5 parts, Herba 2-3 parts, and Rehmannia 5-8 parts.

4. The traditional Chinese medicine composition for treating tachyarrhythmia in women according to claim 1, characterized in that: The dosage form of the composition is a decoction, granules, pills, capsules or oral liquid preparation.

5. Use of the traditional Chinese medicine composition according to any one of claims 1-4 in the preparation of a drug for treating frequent premature ventricular contractions in women.

6. Use of the traditional Chinese medicine composition according to any one of claims 1-4 in the preparation of a drug for treating atrial fibrillation in women.