Traditional Chinese medicine composition for treating bedsore

Abstract

The invention discloses a traditional Chinese medicine composition for treating bedsore. The traditional Chinese medicine composition is prepared from salvia miltiorrhiza, ligusticum wallichii, lucid ganoderma, semen coicis, radix puerariae and honeysuckle. The preparation method comprises an extraction process and a preparation process, wherein the radix salviae miltiorrhizae, the rhizoma chuanxiong, the radix puerariae and the semen coicis are subjected to water extraction, filtration, concentration and spray drying to form powder; extracting ganoderma lucidum with 70% ethanol, filtering, concentrating, and spray-drying to obtain powder; honeysuckle is subjected to water extraction, filtration and standing, and supernate is taken; the extracts are mixed in proportion, and hyaluronic acid and purified water are added to prepare the spray. Experiments and clinical cases show that the composition can remarkably promote healing of bedsore wounds, reduce pus secretion and accelerate growth of granulation tissues, and is convenient to use, high in safety and remarkable in bedsore treatment effect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, specifically to a traditional Chinese medicine composition for treating bedsores. Background Technology

[0002] Pressure ulcers, also known as bedsores, are caused by prolonged pressure on local tissues, leading to impaired blood circulation, tissue ischemia and hypoxia, loss of normal skin function, and resulting in local tissue degeneration, necrosis, and ulceration. Once pressure ulcers develop, they not only increase patient suffering and worsen their condition, but also increase the workload of patients' families and caregivers. In severe cases, secondary infections can occur, such as sepsis, which can be life-threatening. Summary of the Invention

[0003] The purpose of this invention is to provide a traditional Chinese medicine composition for treating bedsores, so as to improve the treatment effect of bedsores.

[0004] To achieve the above objectives, the present invention provides the following technical solution: A traditional Chinese medicine composition for treating bedsores, the formula of which is: Salvia miltiorrhiza, Ligusticum chuanxiong, Ganoderma lucidum, Coix lacryma-jobi, Pueraria lobata, and Lonicera japonica.

[0005] Its preparation methods include extraction and formulation processes, as detailed below: Extraction process: S1, Salvia miltiorrhiza, Ligusticum chuanxiong, Pueraria lobata, Coix lacryma-jobi: Soak in 10 times the amount of water for 2 hours for the first time, boil and extract for 2 hours, filter the liquid through a 120-mesh filter, boil and extract in 8 times the amount of water for 2 hours, filter the liquid through a 120-mesh filter, concentrate to 1.05-1.1, and spray dry into powder.

[0006] S2, Ganoderma lucidum: First, soak in 8 times the amount of 70% ethanol for 12 hours, reflux for 2 hours, filter the liquid through a 120-mesh filter, then reflux for 2 hours, filter the liquid through a 120-mesh filter, concentrate to 1.05-1.1, and spray dry into powder.

[0007] S3, Honeysuckle: Soak in 10 times the amount of water for 2 hours for the first time, heat to 60 degrees Celsius and extract for 2 hours, filter the liquid through a 120-mesh filter. Soak in 8 times the amount of water for the second time, heat to 60 degrees Celsius and extract for 2 hours, filter the liquid through a 120-mesh filter, let the filtrate stand for 24 hours, and take the supernatant.

[0008] Preparation process: Take 3 parts of the mixed powder of Danshen, Chuanxiong, Gegen, and Yiyiren, and 1 part of Lingzhi. Dissolve them in water, filter, take the filtrate, add 1 part of honeysuckle solution, mix evenly, filter again, take the filtrate, and add an appropriate amount of hyaluronic acid and purified water to prepare a spray.

[0009] The following are the functions and effects of each medicinal herb: Salvia miltiorrhiza: Slightly cold in nature, bitter in taste, and enters the heart and liver meridians. It has the effects of removing blood stasis and relieving pain, promoting blood circulation and alleviating menstrual cramps, and clearing the heart and relieving irritability.

[0010] Chuanxiong (Ligusticum striatum): It is warm in nature and pungent in taste, and enters the liver, gallbladder, and pericardium meridians. It has the functions of promoting blood circulation and removing blood stasis, regulating qi and relieving depression, and dispelling wind and relieving pain.

[0011] Reishi mushroom: Neutral in nature, sweet in taste. It enters the heart, lung, liver, and kidney meridians. It has the effects of tonifying qi and calming the mind, relieving cough and asthma.

[0012] Job's tears: Cool in nature, sweet and bland in taste. It enters the spleen, stomach, and lung meridians. It has the functions of promoting diuresis and eliminating dampness, strengthening the spleen and stopping diarrhea, relieving numbness, draining pus, detoxifying and dispersing nodules.

[0013] Kudzu root: pungent in nature and sweet in taste. It enters the spleen and stomach meridians. It has the effects of relieving muscle tension and reducing fever, promoting body fluid production, relieving rashes, raising yang and stopping diarrhea.

[0014] Honeysuckle: It is cold in nature and sweet in taste. It enters the lung, heart and stomach meridians and has the effects of clearing heat and detoxifying, cooling blood and promoting blood circulation.

[0015] The beneficial effects of this invention are as follows: The medicine using the herbal composition described in this application can significantly promote wound healing, granulation tissue growth, and reduce exudate, demonstrating a potent therapeutic effect on pressure ulcers. After patients use this patented medicine, wound purulent secretion decreases rapidly, the time for scab formation and new tissue growth is shortened, and ultimately, complete skin healing is achieved without any adverse reactions, indicating that this application can effectively promote local tissue repair and shorten the treatment cycle.

[0016] The formula contains ingredients such as Salvia miltiorrhiza and Ligusticum chuanxiong, which can improve local blood circulation and relieve tissue ischemia and hypoxia; Ganoderma lucidum and Lonicera japonica have anti-inflammatory and antibacterial effects, which can reduce the risk of wound infection; Coix lacryma-jobi and Pueraria lobata help promote tissue regeneration, which is highly consistent with the pathological mechanism of pressure ulcers of "blood circulation disorder-tissue necrosis-secondary infection", and exerts a multi-target synergistic therapeutic effect.

[0017] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, the preferred embodiments of the present invention are described in detail below. Detailed Implementation

[0018] The specific embodiments of the present invention will be described in further detail below with reference to the examples. These examples are for illustrative purposes only and are not intended to limit the scope of the invention.

[0019] Unless otherwise specified, the technical solutions described in this invention are all conventional solutions in the field; unless otherwise specified, the reagents or materials described are all from commercial sources.

[0020] Formula: 50kg of Salvia miltiorrhiza, 50kg of Ligusticum chuanxiong, 200kg of Ganoderma lucidum, 50kg of Coix lacryma-jobi, 50kg of Pueraria lobata, and 50kg of Lonicera japonica.

[0021] Extraction process: Salvia miltiorrhiza, Ligusticum chuanxiong, Pueraria lobata, and Coix lacryma-jobi: First, soak in 10 times the amount of water for 2 hours, boil and extract for 2 hours, filter the liquid through a 120-mesh filter, then boil and extract in 8 times the amount of water for 2 hours, filter the liquid through a 120-mesh filter, concentrate to 1.05-1.1, and spray dry into powder.

[0022] Ganoderma lucidum: First, soak in 8 times the amount of 70% ethanol for 12 hours, then reflux for 2 hours, filter the liquid through a 120-mesh filter. Second, reflux for 2 hours with 6 times the amount of 70% ethanol, filter the liquid through a 120-mesh filter, concentrate to 1.05-1.1, and spray dry into powder.

[0023] Honeysuckle: Soak in 10 times the amount of water for 2 hours for the first time, heat to 60 degrees Celsius and extract for 2 hours. Filter the liquid through a 120-mesh filter. Soak in 8 times the amount of water for the second time, heat to 60 degrees Celsius and extract for 2 hours. Filter the liquid through a 120-mesh filter. Let the filtrate stand for 24 hours and take the supernatant.

[0024] Preparation process: Take 3 parts of the mixed powder of Danshen, Chuanxiong, Gegen, and Yiyiren, and 1 part of Lingzhi. Dissolve them in water, filter, take the filtrate, add 1 part of honeysuckle solution, mix evenly, filter again, take the filtrate, and add an appropriate amount of hyaluronic acid and purified water to prepare a spray.

[0025] Application Experiment: Thirty stage III pressure ulcer model rats were purchased and randomly divided into three groups: a control group (n=10), a drug group (n=10), and a blank control group (n=10). The control group received wound cleaning with physiological saline three times a day. The drug group received wound cleaning with physiological saline followed by spraying with 1 ml of the prepared drug solution three times a day. The blank control group received no treatment. All groups were housed in cages with free access to food and water.

[0026] Scoring criteria: The wound healing of rats was observed on days 1, 5, 10, and 15 to assess the degree of healing.

[0027] Cured: The ulceration at the pressure sore site has basically disappeared, and the wound is healing well, 4 points; Significant effect: There is no secretion at the pressure ulcer site, the ulcer area is significantly smaller than before treatment, and new granulation tissue grows on the wound, 3 points; Effective: Wound exudate was significantly reduced, and the wound did not expand; 2 points. Ineffective: No significant change in the wound compared to before treatment, 1 point; Death: 0 points.

[0028] Results: Compared with the control group, the drug group showed a significant therapeutic effect on pressure ulcers (P<0.05). The results are shown in the table below: Table 1. Results of pressure ulcer wound scoring in treated rats (x±s, n=10)

[0029] Note: *P<0.05 compared with the control group.

[0030] Typical case: 1. Ms. Liu, 78 years old, suffered from hemiplegia and was bedridden for a long time. Due to inadequate care, she developed an ulcer on her right lower leg, with a wound of approximately 4cm x 6cm and purulent discharge. She was treated with a solution prepared according to this formula. First, the wound was rinsed with saline to remove the purulent discharge. After rinsing, the prepared solution was sprayed onto the wound three times a day. On the third day, the purulent discharge significantly decreased, and treatment continued. On the fifth day, the wound began to scab over, and medication was continued. On the fifteenth day, the wound significantly shrank, with no discharge and minimal pain. New granulation tissue began to grow. After four weeks of treatment, the skin wound completely healed, the skin returned to normal, and the patient experienced no discomfort.

[0031] 2. Mr. Qin, male, 68 years old, was paralyzed after a stroke and had been bedridden for a long time. He developed redness, swelling, and ulceration of the skin on his sacrum and coccyx, with necrosis of skin tissue, purulent exudation, and severe pain, making it impossible for him to lie supine. He was then treated with a solution prepared according to this formula. First, the wound secretions and necrotic tissue were cleaned with physiological saline, and then the prepared solution was sprayed onto the wound. The treatment was carried out daily. By the fifth day, there was basically no purulent exudation from the wound, and the pain was reduced. By the tenth day, the wound began to scab over, and new tissue began to grow. After 6 weeks of treatment, the wound on his sacrum and coccyx healed, the skin returned to normal, and there was no pain or discomfort.

[0032] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0033] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A traditional Chinese medicine composition for treating pressure sores, characterized in that, It is composed of the following raw materials: salvia miltiorrhiza, chuanxiong, ganoderma lucidum, coix seed, pueraria, honeysuckle.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The amount of each raw material is: salvia miltiorrhiza 50 kg, chuanxiong 50 kg, ganoderma lucidum 200 kg, coix seed 50 kg, pueraria 50 kg, and honeysuckle 50 kg.

3. The preparation method of the traditional Chinese medicine composition according to claim 1, characterized in that, It comprises an extraction process and a preparation process, wherein the extraction process is: S1, salvia miltiorrhiza, chuanxiong, pueraria, and coix seed: first soaked in 10 times water for 2 hours, boiled and extracted for 2 hours, filtered with 120 mesh, secondly boiled and extracted with 8 times water for 2 hours, filtered with 120 mesh, concentrated to 1.05-1.1, and then spray dried into powder; S2, ganoderma lucidum: first soaked in 8 times 70% ethanol for 12 hours, reflux extracted for 2 hours, filtered with 120 mesh, secondly reflux extracted with 6 times 70% ethanol for 2 hours, filtered with 120 mesh, concentrated to 1.05-1.1, and then spray dried into powder; S3, honeysuckle: first soaked in 10 times water for 2 hours, extracted at 60 degrees for 2 hours, filtered with 120 mesh, secondly extracted with 8 times water at 60 degrees for 2 hours, filtered with 120 mesh, and the filtrate was left to stand for 24 hours, and then the supernatant was taken.

4. The production method according to claim 3, characterized by, The preparation process is: 3 parts of the mixed powder of salvia miltiorrhiza, chuanxiong, pueraria, and coix seed, and 1 part of ganoderma lucidum are dissolved in water, filtered, and then the filtrate is taken, 1 part of honeysuckle solution is added, mixed uniformly, filtered again, and then the filtrate is taken, and appropriate amount of hyaluronic acid and purified water are added to prepare a spray.

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