Medical guide wire super-lubricating coating structure and construction method thereof

Abstract

The invention provides a medical guide wire super-lubricity coating structure and a construction method, and the method comprises the following steps: soaking a medical guide wire in a coupling agent hydrolysis solution for curing to form a silane film on the surface of the medical guide wire; aromatic polyurethane triacrylate and a polymeric macromolecular photoinitiator are used for preparing a first coating solution, and polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, a polymethyl vinyl ether / maleic anhydride copolymer and a cross-linking agent are used for preparing a second coating solution; the mass ratio of the second coating solution to the first coating solution is (0.9-1.3): 1; soaking the silane film into a first coating solution for ultrasonic treatment, and then curing to form an undetermined hydrophilic coating on the surface of the silane film; the medical guide wire is soaked in the second coating solution to be subjected to ultrasonic treatment, then curing is conducted, and the final hydrophilic coating is obtained. The lubricating property of the medical guide wire coating can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a medical guide wire super-lubricating coating structure and a construction method thereof. BACKGROUND

[0002] Medical catheter or catheter guide wire is a special catheter used in medical treatment or medical operation process, which is used for auxiliary drainage or infusion. According to the classification of medical catheter, it includes one type of medical catheter, two types of medical catheter and three types of medical catheter. One type of medical catheter includes tracheal tube, endotracheal tube, ventricular drainage tube, wound drainage tube, etc. Two types of medical catheter include urinary catheter, gastric tube, intravenous catheter, etc. Three types of catheter include infusion tube, nasal oxygen tube, etc.

[0003] In the prior art, the hydrophilic coating is mainly applied to the surface of the polymer macromolecule. When applied to the surface of the medical intervention metal guide wire, the durability and smoothness of the coating are not ideal, and the firmness of the hydrophilic coating is poor and easy to fall off. SUMMARY

[0004] In view of the deficiencies of the prior art, the purpose of the present application is to provide a construction method of a medical guide wire super-lubricating coating structure to solve the technical problems mentioned in the background.

[0005] In order to achieve the above-mentioned purpose, the present application is realized by the following technical scheme:

[0006] A construction method of a medical guide wire super-lubricating coating structure, comprising the following steps:

[0007] S10, soaking the medical guide wire in a coupling agent hydrolysis solution for solidification to form a silane film on the surface of the medical guide wire;

[0008] S20, preparing a first coating solution using aromatic polyurethane triacrylate and a polymeric macromolecular photoinitiator, and preparing a second coating solution using polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, poly (methyl vinyl ether / maleic anhydride) copolymer and a crosslinking agent; the mass ratio of the second coating solution to the first coating solution is (0.9-1.3):1;

[0009] S30, soaking the silane film in the first coating solution for ultrasonic treatment, and then solidifying to form a to-be-determined hydrophilic coating on the surface of the silane film;

[0010] S40, soaking the medical guide wire in the second coating solution for ultrasonic treatment, and then solidifying to obtain a final hydrophilic coating.

[0011] According to one aspect of the above technical scheme, the solidification temperature in step S10 is 110-140 DEG C, and the solidification time is 1-2 hours.

[0012] According to an aspect of the above technical solution, the ultrasonic treatment time in the step S30 is 25s-35s, the curing temperature is 70℃-90℃, and the curing time is 50s-55s, the ultrasonic treatment time in the step S40 is 5s-10s, the curing temperature is 70℃-90℃, and the curing time is 80s-90s.

[0013] According to an aspect of the above technical solution, when preparing the second coating solution, the mass ratio of the cross-linking agent and the copolymer is (20-90):1.

[0014] According to an aspect of the above technical solution, when preparing the second coating solution, the mass ratio of the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, and polymethyl vinyl ether / maleic anhydride copolymer is (0.8-1.2):(1.3-1.6):1:(1.6-2.3), and the weight percentage of the polyvinylpyrrolidone in the second coating solution is 0.9%.

[0015] According to an aspect of the above technical solution, when preparing the first coating solution, the mass ratio of the aromatic polyurethane triacrylate and the polymerizable macromolecular photoinitiator is 1:0.015, and the weight percentage of the aromatic polyurethane triacrylate in the first coating solution is 6%.

[0016] According to an aspect of the above technical solution, the material of the medical guide wire is nickel-titanium alloy.

[0017] The application also provides a medical guide wire super-lubricating coating structure prepared by the construction method of the medical guide wire super-lubricating coating structure.

[0018] Compared with the prior art, the application has the following beneficial effects:

[0019] By coating the first coating solution prepared from the aromatic polyurethane triacrylate and the polymerizable macromolecular photoinitiator on the surface of the silane film, there is no problem of residue, volatilization, and migration of the photoinitiator, the adhesion between the guide wire and the coating is improved, and an interpenetrating network structure is formed between the guide wire and the coating, thereby avoiding the peeling of the coating; by coating a second coating solution containing the polyacrylamide, the hyaluronic acid, the polyvinylpyrrolidone, and the polymethyl vinyl ether / maleic anhydride copolymer on the first coating solution, the smoothness and the biocompatibility between the first coating solution and the second coating solution are improved, the coating shows good hydrophilicity, the stability of the coating is maintained, the water absorption and swelling capacity of the guide wire coating are not too strong, the bonding force between the metal substrate and the hydrophilic coating to be prepared is obviously improved after the treatment of the silane coupling agent, and the polymer and the cross-linking agent form a cross-linking network when the second coating solution is prepared, thereby improving the durability of the coating. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 This is a flowchart of the method for constructing the super-lubricating coating structure of the medical guidewire in the first embodiment of the present invention;

[0021] The following detailed description, in conjunction with the accompanying drawings, will further illustrate the present invention. Detailed Implementation

[0022] To facilitate understanding of the present invention, a more complete description will be given below with reference to the accompanying drawings. Several embodiments of the invention are illustrated in the drawings. However, the invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

[0023] It should be noted that when a component is said to be "fixed to" another component, it can be directly on the other component or there may be an intervening component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there may be an intervening component. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0025] Example 1

[0026] Please see Figure 1 The diagram illustrates a method for constructing a medical guidewire superlubricating coating structure according to a first embodiment of the present invention, comprising the following steps:

[0027] S10, the medical guidewire is immersed in a coupling agent hydrolysis solution for curing to form a silane film on the surface of the medical guidewire;

[0028] S20, a first coating solution is prepared using aromatic polyurethane triacrylate and a polymeric macromolecular photoinitiator; a second coating solution is prepared using polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, polymethyl vinyl ether / maleic anhydride copolymer, and a crosslinking agent; the mass ratio of the second coating solution to the first coating solution is (0.9~1.3):1;

[0029] S30, the silane membrane is immersed in the first coating solution for ultrasonic treatment, and then cured to form a hydrophilic coating to be determined on the surface of the silane membrane;

[0030] S40, the medical guide wire is immersed into the second coating solution for ultrasonic treatment, and then is solidified to obtain a final hydrophilic coating.

[0031] It can be understood that the present application can improve the adhesion between the guide wire and the coating by coating the first coating solution prepared from the aromatic polyurethane triacrylate and the polymerized macromolecular photoinitiator on the surface of the silane film without the problems of residue, volatilization and migration of the photoinitiator, and can form an interpenetrating network structure with the surface coating to avoid the peeling of the surface coating. The second coating solution containing the polyacrylamide, the hyaluronic acid, the polyvinylpyrrolidone and the polymethyl vinyl ether / maleic anhydride copolymer is coated on the first coating solution to improve the smoothness and biocompatibility between the first coating solution and the second coating solution, and the surface coating is stable and has good hydrophilicity without causing the water absorption and swelling capacity of the guide wire coating to be too strong. After the treatment of the silane coupling agent, the bonding force between the metal substrate and the hydrophilic coating to be prepared is obviously improved. The polymer and the crosslinking agent form a crosslinked network during the preparation of the second coating solution to improve the durability of the coating.

[0032] In the embodiment, the mass ratio of the second coating solution to the first coating solution is 0.9:1.

[0033] Specifically, the solidification temperature in the step S10 is 110℃-140℃, and the solidification time is 1h-2h.

[0034] In the embodiment, the solidification temperature is 110℃, and the solidification time is 1h.

[0035] Further, the ultrasonic treatment time in the step S30 is 25s-35s, the solidification temperature is 70℃-90℃, the solidification time is 50s-55s, the ultrasonic treatment time in the step S40 is 5s-10s, the solidification temperature is 70℃-90℃, and the solidification time is 80s-90s.

[0036] In the embodiment, the ultrasonic treatment time in the step S30 is 25s, the solidification temperature is 70℃, and the solidification time is 50s. The ultrasonic treatment time in the step S40 is 5s, the solidification temperature is 70℃, and the solidification time is 80s.

[0037] Further, the mass ratio of the crosslinking agent to the copolymer during the preparation of the second coating solution is (20-90):1.

[0038] In the embodiment, the mass ratio of the crosslinking agent to the copolymer is 50:1.

[0039] Further, the mass ratio of the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, and polymethyl vinyl ether / maleic anhydride copolymer in the second coating solution is (0.8-1.2):(1.3-1.6):1:(1.6-2.3), and the weight percentage of the polyvinylpyrrolidone in the second coating solution is 0.9%.

[0040] In the embodiment, the mass ratio of the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, and polymethyl vinyl ether / maleic anhydride copolymer is 0.8:1.3:1:1.6.

[0041] Further, when preparing the first coating solution, the mass ratio of the aromatic polyurethane triacrylate and the polymerizable macromolecular photoinitiator is 1:0.015, and the weight percentage of the aromatic polyurethane triacrylate in the first coating solution is 6%.

[0042] Further, the material of the medical guide wire is nickel-titanium alloy.

[0043] Embodiment Two

[0044] In the second embodiment, the curing temperature in the step S10 is 120°C, and the curing time is 1h.

[0045] The ultrasonic treatment time in the step S30 is 30s, the curing temperature is 80°C, and the curing time is 50s, and the ultrasonic treatment time in the step S40 is 5s, the curing temperature is 80°C, and the curing time is 85s.

[0046] The mass ratio of the crosslinking agent and the copolymer is 60:1.

[0047] The mass ratio of the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, and polymethyl vinyl ether / maleic anhydride copolymer is 1.1:1.6:1:2.3.

[0048] Embodiment Three

[0049] In the third embodiment, the curing temperature in the step S10 is 140°C, and the curing time is 1h.

[0050] The ultrasonic treatment time in the step S30 is 35s, the curing temperature is 90°C, and the curing time is 55s, and the ultrasonic treatment time in the step S40 is 10s, the curing temperature is 90°C, and the curing time is 90s.

[0051] The mass ratio of the crosslinking agent and the copolymer is 70:1.

[0052] The mass ratio of the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone and polymethyl vinyl ether / maleic anhydride copolymer is 0.8:1.5:1:2.

[0053] The application reflects the performance through four indexes of the guide wire coating structure.

[0054]

[0055]

[0056] It can be seen from the above table that the medical guide wire coating prepared by the construction method of the medical guide wire super-lubricating coating structure has good performance.

[0057] In conclusion, the construction method of the medical guide wire super-lubricating coating structure in the above embodiments can coat the first coating solution prepared from the aromatic polyurethane triacrylate and the polymeric macromolecular photoinitiator on the surface of the silane film, so that there is no problem of residue, volatilization and migration of the photoinitiator, the adhesion between the guide wire and the coating is improved, and the interpenetrating network structure can be formed with the surface coating, so that the surface coating is prevented from falling off; the second coating solution containing the polyacrylamide, the hyaluronic acid, the polyvinylpyrrolidone and the polymethyl vinyl ether / maleic anhydride copolymer is coated on the first coating solution, so that the lubricity and the biocompatibility between the first coating solution and the second coating solution are improved, the surface coating is stable and has good hydrophilicity, the guide wire coating is prevented from having too strong water absorption and swelling capacity, the bonding force between the metal substrate and the to-be-determined hydrophilic coating is obviously improved after the silane coupling agent treatment, the polymer and the crosslinking agent form the crosslinking network during the preparation of the second coating solution, and the durability of the coating is improved.

[0058] In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "an example", "a specific example" or "some examples" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily mean the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0059] The above-described embodiments only express several implementation manners of the present application, the description is more specific and detailed, but it cannot be understood as the limitation of the patent scope of the present application. It should be noted that, for ordinary skilled persons in the art, several modifications and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A method for constructing a super-lubricating coating structure for a medical guidewire, characterized in that, Includes the following steps: S10, the medical guidewire is immersed in a coupling agent hydrolysis solution for curing to form a silane film on the surface of the medical guidewire; S20, a first coating solution is prepared using aromatic polyurethane triacrylate and a polymeric macromolecular photoinitiator, and a second coating solution is prepared using polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, polymethyl vinyl ether / maleic anhydride copolymer, and a crosslinking agent. The mass ratio of the second coating solution to the first coating solution is (0.9–1.3):1; S30, the silane membrane is immersed in the first coating solution for ultrasonic treatment, and then cured to form a hydrophilic coating to be determined on the surface of the silane membrane; S40, the medical guidewire is immersed in the second coating solution for ultrasonic treatment, and then cured to obtain the final hydrophilic coating.

2. The method for constructing the super-lubricating coating structure of the medical guidewire according to claim 1, characterized in that, The curing temperature in step S10 is 110℃~140℃, and the curing time is 1h~2h.

3. The method for constructing the super-lubricating coating structure of the medical guidewire according to claim 1, characterized in that, In step S30, the ultrasonic treatment time is 25s to 35s, the curing temperature is 70℃ to 90℃, and the curing time is 50s to 55s. In step S40, the ultrasonic treatment time is 5s to 10s, the curing temperature is 70℃ to 90℃, and the curing time is 80s to 90s.

4. The method for constructing the super-lubricating coating structure of the medical guidewire according to claim 1, characterized in that, When preparing the second coating solution, the mass ratio of the crosslinking agent to the copolymer is (20-90):

1.

5. The method for constructing the super-lubricating coating structure of the medical guidewire according to claim 1, characterized in that, When preparing the second coating solution, the mass ratio of polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, and polymethyl vinyl ether / maleic anhydride copolymer is (0.8-1.2):(1.3-1.6):1:(1.6-2.3), and the weight percentage of polyvinylpyrrolidone in the second coating solution is 0.9%.

6. The method for constructing the super-lubricating coating structure of the medical guidewire according to claim 1, characterized in that, When preparing the first coating solution, the mass ratio of the aromatic polyurethane triacrylate to the polymerizable macromolecular photoinitiator is 1:0.015; the weight percentage of the aromatic polyurethane triacrylate in the first coating solution is 6%.

7. The method for constructing the super-lubricating coating structure of the medical guidewire according to claim 1, characterized in that, The medical guidewire is made of nickel-titanium alloy.

8. A super-lubricating coating structure for a medical guidewire, characterized in that, It is made by the method of constructing the medical guidewire super-lubricating coating structure according to any one of claims 1 to 7.

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