Hydrophobically Modified Brown Alginate Oligosaccharide Micelles, Preparation Methods and Applications

CN120988151BActive Publication Date: 2026-05-26SHENZHEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN UNIV
Filing Date
2025-07-03
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

In existing technologies, alginate oligosaccharide liposomes have poor stability, resulting in poor drug loading, low encapsulation rate of bioactive substances, and inability to effectively deliver them to the target.

Method used

Hydrophobically modified alginate oligosaccharide micelles are used to form nanoscale micelles by reacting alginate oligosaccharides with hydrophobic fatty acids. These micelles have a hydrophobic core and a hydrophilic shell structure, are loaded with fat-soluble nutrients, and are stabilized by bridging with cystamine and catalyst and heat treatment.

Benefits of technology

It improves the encapsulation efficiency and stability of lipid-soluble substances, enhances bioavailability, reduces toxic side effects, achieves targeted drug delivery and controlled release, and adapts to responsive release under inflammatory conditions.

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Abstract

This invention relates to the field of pharmaceutical formulation technology, specifically to a hydrophobically modified alginate oligosaccharide micelle, its preparation method, and its application. The alginate oligosaccharide micelle provided by this invention uses alginate oligosaccharide as a raw material, and is obtained by reacting alginate oligosaccharide with hydrophobic fatty acids. The micelles provided by this invention are nanoscale, and their structure of a hydrophobic core and hydrophilic shell can effectively load lipid-soluble substances. Simultaneously, by introducing hydrophobic fatty acids for derivatization modification, on the one hand, derivatization modification can structurally alter the amphiphilicity of alginate oligosaccharide, developing its function of encapsulating hydrophobic bioactive substances; on the other hand, derivatization modification of alginate oligosaccharide can endow the micelles with active targeting or responsive release capabilities, significantly improving the bioavailability of hydrophobic bioactive substances.
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