A method for preparing anthocyanin-coated nanoparticles and its application

CN121015626BActive Publication Date: 2026-06-30HARBIN UNIV OF COMMERCE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN UNIV OF COMMERCE
Filing Date
2025-07-17
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing medications for treating depression have side effects, significant individual differences in efficacy, and long treatment cycles. Furthermore, honeysuckle anthocyanins are unstable and easily degraded, limiting their application in the treatment of depression.

Method used

A composite droplet of honeysuckle berry anthocyanin and squalene was formed, and EVs@Sq@An nanoparticles with a particle size of 180~220nm, a zeta potential of -45~-55mV, and an encapsulation efficiency of ≥85% were prepared by encapsulating honeysuckle berry-derived extracellular vesicles. These nanoparticles were used to regulate gut microbiota and improve depressive symptoms.

Benefits of technology

The prepared nanoparticles exhibit good stability and biocompatibility, and can achieve antidepressant, antioxidant, and anti-inflammatory effects by regulating gut microbiota and improving depressive-like behaviors, providing a safe and efficient treatment pathway for depression.

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Abstract

This invention discloses a method for preparing anthocyanin-coated nanoparticles and their applications. First, anthocyanins and extracellular vesicles (EVs) are extracted from honeysuckle fruit to obtain anthocyanin powder. Then, PBS and squalene are added to the anthocyanin powder to obtain squalene@anthocyanin. Next, EVs are added to squalene@anthocyanin, co-incubated, and then centrifuged to obtain anthocyanin-coated nanoparticles. These nanoparticles have a particle size of 180-220 nm, a zeta potential of -45 to -55 mV, and an encapsulation efficiency ≥85%. They exhibit excellent stability and biocompatibility, possessing functions such as regulating gut microbiota, antidepressant, antioxidant, and anti-inflammatory effects. Furthermore, their good biocompatibility and low toxicity solve the problems of stability and bioavailability, achieving precise regulation of gut microbiota and providing a safe and efficient new approach for the treatment of depression.
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