Blood perfusion device for pesticide poisoning treatment

Abstract

The invention relates to the technical field of medical instruments, and particularly discloses a blood perfusion device for pesticide poisoning treatment. The blood perfusion mechanism is arranged on one side of the machine shell, and the blood perfusion mechanism is used for adsorbing toxins in blood of a patient; according to the invention, through cooperative movement of components of the initial threshold mechanism, the secondary threshold mechanism and the dynamic adjusting mechanism, the rotating speed is deeply matched with the individual demand of a patient, and through linkage adjustment of an electric push rod, a connecting plate and a sliding sheet, the rotating speed of the patient can be accurately adjusted. The initial rotating speed threshold value of the blood pump is precisely limited in an adaptive interval, the rotating speed threshold value of the blood pump is deeply matched with the specific condition of a patient through the secondary threshold value mechanism, dynamic fine adjustment of the rotating speed within a safety threshold value is achieved through the dynamic adjusting mechanism, and when the patient has circulating fluctuation, the rotating speed of the blood pump is adjusted.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a blood perfusion device for pesticide poisoning treatment. BACKGROUND

[0002] Acute organophosphorus pesticide poisoning is a high-incidence acute and critical illness in primary medical institutions in China, accounting for 20%-50% of acute poisoning cases. It has rapid onset and rapid progression. If not treated in time, the mortality rate can be as high as 83.6%. Patients often die of complications such as respiratory failure, pulmonary edema, and brain edema. Clinical studies have confirmed that organophosphorus toxins cause poisoning symptoms by inhibiting cholinesterase activity and causing acetylcholine accumulation. The lower the cholinesterase activity, the more severe the poisoning (the activity of patients with severe poisoning is often lower than 30% of the normal value). Therefore, the core of treatment is to quickly remove toxins, accurately detoxify, and maintain stable circulation.

[0003] The existing blood perfusion device can only set a single fixed rotation speed threshold, and the blood pump rotation speed directly affects the toxin removal efficiency and patient circulation tolerance. High rotation speed can easily cause complications such as hypotension and hemolysis, and low rotation speed cannot effectively remove toxins. The existing blood perfusion device does not consider individual differences of different patients, which can easily cause perfusion-related circulation complications or incomplete toxin removal causing rebound. Therefore, we propose a blood perfusion device for pesticide poisoning treatment. SUMMARY

[0004] The purpose of the present application is to provide a blood perfusion device for pesticide poisoning treatment to solve the problem of the existing blood perfusion device not considering individual differences of different patients, which can easily cause perfusion-related circulation complications or incomplete toxin removal causing rebound as mentioned in the background.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a blood perfusion device for pesticide poisoning treatment, comprising: a casing;

[0006] Further comprising: a blood perfusion mechanism, the blood perfusion mechanism is arranged on one side of the casing, and the blood perfusion mechanism adsorbs toxins in the blood of the patient;

[0007] An initial threshold mechanism, the initial threshold mechanism is arranged in the interior of the casing, and the initial threshold mechanism limits the initial rotation speed threshold of the blood pump of the casing according to the tolerance of the patient;

[0008] A secondary threshold mechanism, the secondary threshold mechanism is arranged on one side of the initial threshold mechanism, and the secondary threshold mechanism performs secondary adjustment on the initial rotation speed threshold of the blood pump set by the initial threshold mechanism according to the body type, poisoning time, and poisoning amount of the patient;

[0009] The dynamic adjustment mechanism is arranged on one side of the initial threshold mechanism, and adjusts the rotating speed of the blood pump of the shell according to the blood pump threshold set by the initial threshold mechanism and the secondary threshold mechanism.

[0010] The drug injection mechanism is arranged on one side of the shell, and the drug injection mechanism injects the antidote.

[0011] The blood perfusion mechanism comprises a perfusion device clamped on one side of the shell, an access pipe fixedly connected to an input end of the perfusion device, the surface of the access pipe clamped in the interior of the shell blood pump, a first outflow pipe fixedly connected to an output end of the perfusion device, one end of the first outflow pipe fixedly connected to a Y-shaped pipe, the Y-shaped pipe arranged in the clamping piece of the shell, one end of the Y-shaped pipe fixedly connected to a second outflow pipe.

[0012] The initial threshold mechanism comprises a placing box arranged in the interior of the shell, an electric push rod fixedly connected to the interior of the placing box, a first sliding sheet arranged at one end of the electric push rod, a second resistance strip slidingly connected to the interior of the first sliding sheet, a first protective box sleeved to the surface of the second resistance strip, and the second resistance strip fixedly connected to the interior of the first protective box.

[0013] One end of the electric push rod is fixedly connected to a connecting plate, the connecting plate is fixedly connected to one end of the first sliding sheet, and a first sliding groove is formed in the top of the first protective box for sliding of the first sliding sheet.

[0014] One side of the connecting plate is fixedly connected to a fixed plate, the fixed plate is sleeved with an electromagnetic brake in the interior, the electromagnetic brake is slidingly connected with a guide rod in the interior, and the guide rod is fixedly connected to the interior of the first protective box.

[0015] The secondary threshold mechanism comprises a first guide block fixedly connected to the bottom of the first protective box, a first guide rail slidingly connected to the interior of the first guide block, a first sliding block fixedly connected to the interior of the first guide block, a first screw rod slidingly connected to the interior of the first sliding block, a coupling fixedly connected to one end of the first screw rod, a fixed motor fixedly connected to one end of the coupling, a support plate fixedly connected to the bottom of the fixed motor, the support plate fixedly connected to the interior of the placing box, and the first guide rail fixedly connected to the top of the support plate through the first protrusion at the bottom.

[0016] The dynamic adjustment mechanism comprises a worm rotatably connected to the interior of the placing box, a knob fixedly connected to one end of the worm, an empty slot formed in one end of the placing box and matched with the knob, a worm gear meshed between the teeth of the worm, a second screw rod fixedly connected to the interior of the worm gear, a second sliding block slidingly connected to the surface of the second screw rod, a second sliding sheet fixedly connected to the top of the second sliding block, a first resistance strip slidingly connected to the interior of the second sliding sheet, a second protective box sleeved to the surface of the first resistance strip, and the second protective box fixedly connected to the interior of the placing box.

[0017] The bottom of the second sliding block is fixedly connected with a second guide block, the inside of the second guide block is slidably connected with a second guide rail, the bottom of the second guide rail is fixedly connected with a supporting rod, and the supporting rod is fixedly connected inside the placing box.

[0018] The drug injection mechanism comprises a speed regulating motor arranged inside the shell, the output end of the speed regulating motor is fixedly connected with a driving gear, the driving gear is meshed with a driven gear between the teeth, the bottom of the driven gear is rotatably connected with a limiting piece, the limiting piece is fixedly connected to one end of the shell, the inside of the driven gear is slidably connected with a third lead screw, the bottom of the third lead screw is in contact with a syringe, one end of the syringe is fixedly connected with a connecting pipe, and one end of the connecting pipe is clamped inside the Y-shaped pipe.

[0019] A display panel is arranged at the top of one end of the shell, and a key panel is arranged on the side of the shell close to the display panel.

[0020] The present application has at least the following advantages:

[0021] The present application realizes the deep matching of the rotation speed and the individual needs of the patient through the cooperative movement of the components of the initial threshold mechanism, the secondary threshold mechanism and the dynamic adjustment mechanism. The initial rotation speed threshold of the blood pump is accurately limited in the adaptive interval through the linkage adjustment of the "electric push rod-connection plate-sliding sheet". The secondary threshold mechanism deeply matches the rotation speed threshold of the blood pump with the specific situation of the patient. The dynamic adjustment mechanism realizes the dynamic fine adjustment of the rotation speed within the safety threshold, and adjusts the rotation speed of the blood pump when the patient has a circulation fluctuation.

[0022] The present application realizes the "path avoidance + time sequence synchronization" through the cooperative movement of the components of the blood perfusion mechanism and the drug injection mechanism, maximizes the drug effect of the detoxifying agent, and drives the patient's blood containing toxins to enter the perfusion device through the access pipe. The organic phosphorus toxin is adsorbed by the built-in resin, the purified blood flows into the Y-shaped pipe through the first outflow pipe, the connecting pipe of the drug injection mechanism is clamped into the side opening of the Y-shaped pipe, the detoxifying agent is injected through this, mixed with the purified blood, and then returned to the patient through the second outflow pipe. In the whole blood flow path, the detoxifying agent is always located downstream of the perfusion device and does not pass through the inside of the perfusion device, so that the effective concentration of the detoxifying agent is improved. The drug injection is realized through the gear-screw transmission of the mechanism to realize the accurate time sequence and speed control, realizes the "synchronous mixing and return of purified blood and detoxifying agent", and avoids the neutralization of high-concentration toxins in the un-purified blood and the detoxifying agent. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is a perspective view of the present application;

[0024] Figure 2 It is a front view of the present application;

[0025] Figure 3 It is a perspective view of the drug injection mechanism of the present application;

[0026] Figure 4 The front view schematic diagram of the placing box of the present application;

[0027] Figure 5 The perspective view schematic diagram of the placing box of the present application;

[0028] Figure 6 The perspective view schematic diagram of the dynamic adjustment mechanism of the present application;

[0029] Figure 7 The perspective view schematic diagram of the initial threshold mechanism of the present application;

[0030] Figure 8 The schematic diagram of A of the present application.

[0031] In the figure: 1, the shell; 2, the blood perfusion mechanism; 21, the perfusion device; 22, the access pipe; 23, the first outflow pipe; 24, the Y-shaped pipe; 25, the second outflow pipe; 3, the initial threshold mechanism; 31, the placing box; 32, the electric push rod; 33, the first sliding sheet; 34, the second resistance strip; 35, the first protective box; 36, the connecting plate; 4, the secondary threshold mechanism; 41, the first guide block; 42, the first guide rail; 43, the first sliding block; 44, the first lead screw; 45, the coupling; 46, the fixed motor; 47, the support plate; 5, the dynamic adjustment mechanism; 51, the worm; 52, the knob; 53, the worm wheel; 54, the second lead screw; 55, the second sliding block; 56, the second sliding sheet; 57, the first resistance strip; 58, the second protective box; 6, the drug bolus injection mechanism; 61, the speed regulation motor; 62, the driving gear; 63, the driven gear; 64, the limiting piece; 65, the third lead screw; 66, the syringe; 67, the connecting pipe; 7, the fixed plate; 8, the electromagnetic brake; 9, the guide rod; 10, the second guide block; 11, the second guide rail; 12, the support rod; 13, the display panel; 14, the key plate. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0033] Embodiment one

[0034] Please refer to Figures 1 to 8 The present application provides a technical solution: a blood perfusion device for pesticide poisoning treatment, comprising: a shell 1;

[0035] Further comprising: a blood perfusion mechanism 2 arranged on one side of the casing 1, the blood perfusion mechanism 2 adsorbing toxins in the blood of the patient;

[0036] An initial threshold mechanism 3 arranged inside the casing 1, the initial threshold mechanism 3 limiting the range of the initial rotating speed threshold of the blood pump of the casing 1 according to the tolerance of the patient;

[0037] A secondary threshold mechanism 4 arranged on one side of the initial threshold mechanism 3, the secondary threshold mechanism 4 secondarily adjusting the initial rotating speed threshold of the blood pump set by the initial threshold mechanism 3 according to the body type, poisoning time and poisoning drug amount of the patient;

[0038] A dynamic adjustment mechanism 5 arranged on one side of the initial threshold mechanism 3, the dynamic adjustment mechanism 5 adjusting the rotating speed of the blood pump of the casing 1 according to the threshold of the blood pump set by the initial threshold mechanism 3 and the secondary threshold mechanism 4;

[0039] A drug bolus mechanism 6 arranged on one side of the casing 1, the drug bolus mechanism 6 bolus injecting the antidote.

[0040] The casing 1 provides an installation carrier and a power transmission basis for each functional mechanism, integrating the blood pump (core power component, driving blood circulation perfusion), the display panel 13 and the key panel 14;

[0041] The secondary threshold mechanism 4 secondarily corrects the rotating speed threshold of the blood pump on the basis of the initial threshold, in combination with the body type (weight, body surface area), poisoning time and poisoning drug amount of the patient, to improve the adaptability;

[0042] The dynamic adjustment mechanism 5 adjusts the actual rotating speed of the blood pump in real time based on the initial and secondary threshold ranges, to adapt to the circulation state of the patient in the treatment of organophosphorus poisoning;

[0043] The drug bolus mechanism 6 bolus injects the organophosphorus antidote (such as atropine for resisting M-like symptoms, and pralidoxime iodide for reviving cholinesterase) into the blood circuit at a set speed, to form a clearance and detoxification synergy with the perfusion adsorption.

[0044] The liquid casing mechanism comprises a perfusion device 21 clamped on one side of the casing 1, an access pipe 22 fixedly connected to the input end of the perfusion device 21, the surface of the access pipe 22 being clamped in the inside of the blood pump of the casing 1, a first outflow pipe 23 fixedly connected to the output end of the perfusion device 21, one end of the first outflow pipe 23 being fixedly connected with a Y-shaped pipe 24, the Y-shaped pipe 24 being arranged in the clamping piece of the casing 1, and a second outflow pipe 25 fixedly connected to one end of the Y-shaped pipe 24.

[0045] The perfusion device 21 is internally provided with an adsorption material special for organophosphorus toxins, which is a core component for adsorbing organophosphorus toxins (such as phosphate compounds) in blood, and removes the toxins in the blood circulation through physical adsorption to avoid the toxins from further acting on cholinesterase. The access pipe 22 is connected to the patient's artery at one end and fixedly connected to the input end of the perfusion device 21 at the other end, and is clamped on the inside of the blood pump of the casing 1. The patient's blood containing toxins is introduced into the perfusion device 21 through the driving force of the blood pump. The first outflow pipe 23 is connected to the output end of the perfusion device 21 and the Y-shaped pipe 24, and the blood purified by the perfusion device 21 is delivered to the Y-shaped pipe 24. The Y-shaped pipe 24 realizes the mixing function of the purified blood and the antidote. One end of the Y-shaped pipe 24 is connected to the first outflow pipe 23 (for purified blood), one end is connected to the connecting pipe 67 of the drug injection mechanism 6 (for antidote), and the other end is connected to the second outflow pipe 25 (for mixed liquid). The second outflow pipe 25 connects the Y-shaped pipe 24 and the patient's blood vessel, and the purified blood containing organophosphorus antidote is returned to the patient's body, and the blood circulation perfusion is completed.

[0046] The initial threshold mechanism 3 includes a placement box 31 arranged inside the casing 1. The inside of the placement box 31 is fixedly connected with an electric push rod 32. One end of the electric push rod 32 is provided with a first sliding sheet 33. The inside of the first sliding sheet 33 is slidably connected with a second resistance strip 34. The surface of the second resistance strip 34 is sleeved with a first protective box 35. The second resistance strip 34 is fixedly connected inside the first protective box 35.

[0047] One end of the electric push rod 32 is fixedly connected with a connecting plate 36. The connecting plate 36 is fixedly connected to one end of the first sliding sheet 33. The top of the first protective box 35 is provided with a first sliding groove for the sliding of the first sliding sheet 33.

[0048] The placement box 31 provides fixed support for the electric push rod 32, the second resistance strip 34 and other components in the initial threshold mechanism 3, so as to avoid displacement of the components when the casing 1 is running. The electric push rod 32, the connecting plate 36 and the first sliding sheet 33 adjust the resistance value of the second resistance strip 34 according to the tolerance of the patient (such as the tolerance of elderly patients and shock state patients is low, and the tolerance of young patients is high). The electric push rod 32 is telescopic to drive the connecting plate 36, and then push the first sliding sheet 33 to slide along the surface of the second resistance strip 34, so as to change the resistance of the circuit. The blood pump speed is associated with the resistance of the second resistance strip 34 (the resistance value corresponds to the speed threshold, such as low resistance corresponds to high speed threshold, and high resistance corresponds to low speed threshold), so as to limit the initial speed range of the blood pump. The second resistance strip 34 is a core parameter adjustment component in the initial threshold mechanism 3, which outputs the initial speed threshold electrical signal to the blood pump controller through resistance change. The first protective box 35 protects the second resistance strip 34 from dust erosion inside the casing 1, so as to ensure the resistance adjustment accuracy.

[0049] A fixing plate 7 is fixedly connected to one side of the connecting plate 36. An electromagnetic brake 8 is sleeved inside the fixing plate 7. A guide rod 9 is slidably connected inside the electromagnetic brake 8. The guide rod 9 is fixedly connected inside the first protective box 35.

[0050] The electromagnetic brake 8 and the guide rod 9 function as follows: when the first sliding plate 33 slides to the target initial threshold position, the electromagnetic brake 8 is energized to attract the guide rod 9 (the guide rod 9 is fixed inside the first protective box 35), and the position of the first sliding plate 33 is locked by the fixing plate 7 to prevent the initial threshold from shifting during the perfusion process.

[0051] The secondary threshold mechanism 4 includes a first guide block 41 fixedly connected to the bottom of the first protective box 35, a first guide rail 42 slidably connected inside the first guide block 41, a first slider 43 fixedly connected inside the first guide block 41, a first lead screw 44 slidably connected inside the first slider 43, a coupling 45 fixedly connected to one end of the first lead screw 44, a fixed motor 46 fixedly connected to one end of the coupling 45, a support plate 47 fixedly connected to the bottom of the fixed motor 46, the support plate 47 fixedly connected inside the placement box 31, and the first guide rail 42 fixedly connected to the top of the support plate 47 via a first protrusion at the bottom.

[0052] The fixed motor 46 (power source) drives the coupling 45 to rotate the first lead screw 44 based on the patient parameters (such as weight 50kg, poisoning time 3h, poisoning dose 10ml dichlorvos) input by medical staff through the keypad 14. The rotation of the first lead screw 44 is converted into the linear motion of the first slider 43 (the first slider 43 is sleeved on the first lead screw 44), which drives the first guide block 41 to slide along the first guide rail 42 (the first guide rail 42 is fixed to the top of the support plate 47 by the bottom protrusion). The first guide block 41 is linked with the first protective box 35 and the second resistor strip 34 inside, and the resistance value of the second resistor strip 34 is finely adjusted.

[0053] The dynamic adjustment mechanism 5 includes a worm gear 51 rotatably connected inside the placement box 31. A knob 52 is fixedly connected to one end of the worm gear 51. A slot adapted to the knob 52 is opened at one end of the placement box 31. A worm wheel 53 meshes between the teeth of the worm gear 51. A second lead screw 54 is fixedly connected inside the worm wheel 53. A second slider 55 is slidably connected to the surface of the second lead screw 54. A second sliding plate 56 is fixedly connected to the top of the second slider 55. A first resistance strip 57 is slidably connected inside the second sliding plate 56. A second protective box 58 is sleeved on the surface of the first resistance strip 57. The second protective box 58 is fixedly connected inside the placement box 31.

[0054] The medical staff observes the display panel 13 and the patient's vital signs (such as blood pressure falling below 90 / 60 mmHg), rotates the knob 52 to drive the worm 51 to rotate, the worm 51 and the worm gear 53 convert the rotary motion of the knob 52 into the vertical rotation of the worm gear 53 (the worm 51 and the worm gear 53 are meshed), and then drive the second lead screw 54 (fixed in the inside of the worm gear 53) to rotate, the second lead screw 54 drives the second sliding block 55 to move linearly along the second lead screw 54, and drives the second sliding block 56 at the top to slide along the first resistance strip 57 (the first resistance strip 57 is associated with the blood pump rotation speed electric signal), so as to change the actual rotation speed of the blood pump.

[0055] The bottom of the second sliding block 55 is fixedly connected with the second guide block 10, the inside of the second guide block 10 is slidably connected with the second guide rail 11, the bottom of the second guide rail 11 is fixedly connected with the supporting rod 12, and the supporting rod 12 is fixedly connected in the inside of the placing box 31.

[0056] The second guide block 10 and the second guide rail 11 limit the movement direction of the second sliding block 55, avoid sliding deviation, the second protective box 58 protects the first resistance strip 57, ensures the adjustment accuracy, the supporting rod 12 fixes the second guide rail 11, and the stability of the mechanism is enhanced.

[0057] The medicine injection mechanism 6 comprises a speed regulating motor 61 arranged in the inside of the shell 1, the output end of the speed regulating motor 61 is fixedly connected with a driving gear 62, the driving gear 62 is meshed with a driven gear 63, the bottom of the driven gear 63 is rotatably connected with a limiting piece 64, the limiting piece 64 is fixedly connected with one end of the shell 1, the inside of the driven gear 63 is slidably connected with a third lead screw 65, the bottom of the third lead screw 65 is in contact with a syringe 66, one end of the syringe 66 is fixedly connected with a connecting pipe 67, and one end of the connecting pipe 67 is clamped in the inside of the Y-shaped pipe 24.

[0058] The speed regulating motor 61 drives the driving gear 62 to rotate according to the treatment requirement, the driving gear 62 is meshed and drives the driven gear 63 to rotate (the limiting piece 64 is fixed to the bottom of the driven gear 63, so as to avoid axial displacement), the driven gear 63 is provided with a thread matched with the third lead screw 65 in the inside, the rotation of the driven gear 63 is converted into the vertical downward movement of the third lead screw 65, the syringe 66 piston is pushed, the syringe 66 is provided with organophosphorus antidote, and the piston pushes the antidote to be injected into the Y-shaped pipe 24 through the connecting pipe 67 after being pressed, the antidote is mixed with the purified blood and is returned to the patient, the antidote reaches the lesion along with the blood, the antidote is avoided from being adsorbed by the perfusion device 21 (the Y-shaped pipe 24 is located downstream of the perfusion device 21, so as to ensure that the antidote does not pass through the perfusion device 21), and the injection speed is controlled by changing the motor speed, for example, when the patient has atropinization signs (pupil dilation, dry mouth), the medical staff reduces the motor speed of the speed regulating motor 61 through the key plate 14, and reduces the injection amount of the antidote.

[0059] The top of one end of the casing 1 is provided with a display panel 13, and the side of the casing 1 close to the display panel 13 is provided with a key panel 14.

[0060] The display panel 13 displays the blood pump speed, perfusion time, antidote bolus, patient vital signs, and organic phosphorus toxin adsorption progress (indirectly fed back through the blood pump parameters) in real time, so as to facilitate the medical staff to monitor the treatment state, and the key panel 14 receives the operation instructions of the medical staff, such as starting / stopping perfusion, setting initial parameters (such as patient tolerance level), and adjusting the antidote bolus speed, to realize human-computer interaction.

[0061] Embodiment Two

[0062] As Figures 1 to 2 In this embodiment two, other structures are unchanged, and different from embodiment one, the inside of the casing 1 close to the display panel 13 is provided with a microcontroller, and the top of the casing 1 is provided with a multi-parameter monitor.

[0063] The multi-parameter monitor monitors the key indicators of the organic phosphorus poisoning patient in real time, including vital signs (heart rate, blood pressure, and blood oxygen saturation), and cholinesterase activity (a core indicator of organic phosphorus poisoning, and the lower the activity, the more severe the poisoning), and transmits the data to the microcontroller, the microcontroller receives the multi-parameter monitor data, automatically adjusts the blood pump speed and the antidote bolus, for example: when the cholinesterase activity is less than 30% (severe poisoning), the microcontroller controls the fixed motor 46 to increase the blood pump speed threshold, and at the same time, increases the speed of the speed regulation motor 61 to increase the antidote bolus; when the blood pressure is less than 85 / 55 mmHg, the dynamic adjustment mechanism 5 is automatically controlled to reduce the blood pump speed, and the adjusted parameters (such as real-time speed and bolus) are transmitted to the display panel 13, and at the same time, an alarm is triggered (such as insufficient antidote, and the blood pump speed exceeds the threshold) when the parameters are abnormal, and after the medical staff inputs the patient's basic information through the key panel 14, the microcontroller can automatically calculate the initial / secondary threshold, without manually adjusting the electric push rod 32 and the fixed motor 46, to improve the treatment efficiency.

[0064] Collaboration of each mechanism

[0065] 1. Collaboration of blood perfusion and drug bolus

[0066] Timing coordination: after the casing is started, the blood pump first drives the blood into the perfusion device 21 to adsorb the organic phosphorus toxin, and when the purified blood flows into the Y-shaped tube 24, the drug bolus mechanism 6 is started at the same time, to ensure that the antidote is mixed with the purified blood, and to avoid that the high concentration of toxin in the un-purified blood neutralizes the antidote;

[0067] Path coordination: the antidote is injected into the Y-shaped tube 24 (downstream of the perfusion device 21) through the connecting pipe 67, without passing through the perfusion device 21, to prevent the antidote from being adsorbed by the perfusion device 21, and to ensure the effective concentration of the antidote.

[0068] 2. Level matching of speed regulation mechanism

[0069] Initial threshold mechanism 3 and secondary threshold mechanism 4: first set the basic speed range according to the patient's tolerance, and then correct the threshold according to the body size, poisoning time and drug amount, to form a level adjustment of basic adaptation and precise correction;

[0070] Secondary threshold mechanism 4 and dynamic adjustment mechanism 5: dynamic adjustment mechanism 5 takes the secondary corrected threshold as the boundary to fine-tune the speed in real time (the blood pump speed can be adjusted according to the blood drug concentration), to ensure that the speed is always within the safe and effective speed value, avoiding exceeding the patient's tolerance or being lower than the toxin removal requirement.

[0071] 3. Central coordination of microcontroller

[0072] Data reception: receiving cholinesterase activity, blood pressure and other data from the multi-parameter monitor, and receiving manual instructions from the key panel 14,

[0073] Instruction output: sending adjustment instructions to the initial threshold mechanism 3 (controlling the electric push rod 32), the secondary threshold mechanism 4 (controlling the fixed motor 46) and the drug bolus mechanism 6 (controlling the speed regulation motor 61), to realize the automation of "monitoring, analyzing and adjusting" and reduce human operation errors.

[0074] 4. Synergistic intervention of toxin removal and detoxification

[0075] Timing coordination: after the blood pump is started, the blood is first driven into the perfusion device 21 to adsorb toxins (the circuit is filled within 30 seconds), and then the drug bolus mechanism 6 is started - to avoid the combination of high-concentration toxins in un-purified blood and detoxifying agents, reducing the detoxification effect;

[0076] Action coordination: the perfusion device 21 removes the absorbed organophosphorus toxins, reducing the inhibition of cholinesterase by toxins; the detoxifying agent (such as atropine to counteract M-like symptoms and pralidoxime to reactivate cholinesterase) directly blocks the poisoning pathological process, forming a dual effect of source removal and symptom control, accelerating patient recovery.

[0077] 5. Parameter adjustment-circulation stability coordination

[0078] Level coordination: the initial threshold mechanism 3 sets the basic speed range, the secondary threshold mechanism 4 corrects according to individual differences, and the dynamic adjustment mechanism 5 responds to circulation changes in real time, to ensure that the speed is always within the safe (not causing circulation complications) and effective (ensuring toxin removal) range through three-level adjustment;

[0079] Monitoring coordination: the multi-parameter monitor provides feedback on the circulation state in real time, providing a basis for dynamic adjustment (such as blood pressure drop, dynamic adjustment to reduce speed), to avoid risks caused by blind adjustment and to achieve a balance between treatment needs and circulation tolerance.

[0080] The above electronic devices are powered by internal batteries (not shown) or external leads (not shown).

[0081] It is to be understood that the terminology used herein such as first and second, and the like, is only used to distinguish one entity or action from another entity or action, and does not necessarily require or imply that there is any such actual relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus.

[0082] While embodiments of the present application have been shown and described, it is to be understood that the embodiments described are merely divergences, modifications, replacements and variations of the embodiments of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A blood perfusion device for treating pesticide poisoning, comprising: chassis; Its characteristic is that it further includes: a blood perfusion mechanism, which is disposed on one side of the machine housing, and the blood perfusion mechanism adsorbs toxins in the patient's blood; An initial threshold mechanism is disposed inside the casing, which limits the range of the initial rotational speed threshold of the blood pump in the casing according to the patient's tolerance. A secondary threshold mechanism is provided on one side of the initial threshold mechanism. The secondary threshold mechanism adjusts the initial blood pump speed threshold set by the initial threshold mechanism a second time according to the patient's body size, poisoning time, and dosage of poisoning drug. A dynamic adjustment mechanism is provided on one side of the initial threshold mechanism. The dynamic adjustment mechanism adjusts the rotation speed of the blood pump in the casing according to the blood pump threshold set by the initial threshold mechanism and the secondary threshold mechanism. A drug injection mechanism is located on one side of the housing, and the drug injection mechanism injects the antidote.

2. The blood perfusion device for treating pesticide poisoning according to claim 1, characterized in that: The blood perfusion mechanism includes a perfusion device that is snapped onto one side of the housing. The input end of the perfusion device is fixedly connected to an inlet tube, the surface of which is snapped into the inside of the blood pump in the housing. The output end of the perfusion device is fixedly connected to a first outlet tube, one end of which is fixedly connected to a Y-shaped tube. The Y-shaped tube is located inside the snap-fit ​​component of the housing, and one end of which is fixedly connected to a second outlet tube.

3. The blood perfusion device for treating pesticide poisoning according to claim 1, characterized in that: The initial threshold mechanism includes a placement box disposed inside the housing. An electric push rod is fixedly connected inside the placement box. A first sliding piece is provided at one end of the electric push rod. A second resistance strip is slidably connected inside the first sliding piece. A first protective box is sleeved on the surface of the second resistance strip. The second resistance strip is fixedly connected inside the first protective box.

4. The blood perfusion device for treating pesticide poisoning according to claim 3, characterized in that: One end of the electric push rod is fixedly connected to a connecting plate, and the connecting plate is fixedly connected to one end of the first sliding piece. The top of the first protective box is provided with a first sliding groove for the first sliding piece to slide.

5. The blood perfusion device for treating pesticide poisoning according to claim 3, characterized in that: A fixing plate is fixedly connected to one side of the connecting plate. An electromagnetic brake is sleeved inside the fixing plate. A guide rod is slidably connected inside the electromagnetic brake. The guide rod is fixedly connected inside the first protective box.

6. The blood perfusion device for treating pesticide poisoning according to claim 3, characterized in that: The secondary threshold mechanism includes a first guide block fixedly connected to the bottom of the first protective box, a first guide rail slidably connected inside the first guide block, a first slider fixedly connected inside the first guide block, a first lead screw slidably connected inside the first slider, a coupling fixedly connected to one end of the first lead screw, a fixed motor fixedly connected to one end of the coupling, a support plate fixedly connected to the bottom of the fixed motor, the support plate fixedly connected inside the placement box, and the first guide rail fixedly connected to the top of the support plate via a first protrusion at the bottom.

7. The blood perfusion device for treating pesticide poisoning according to claim 3, characterized in that: The dynamic adjustment mechanism includes a worm gear rotatably connected inside the placement box. A knob is fixedly connected to one end of the worm gear. A slot adapted to the knob is opened at one end of the placement box. A worm wheel meshes between the teeth of the worm gear. A second lead screw is fixedly connected inside the worm wheel. A second slider is slidably connected to the surface of the second lead screw. A second sliding plate is fixedly connected to the top of the second slider. A first resistance strip is slidably connected inside the second sliding plate. A second protective box is sleeved on the surface of the first resistance strip. The second protective box is fixedly connected inside the placement box.

8. The blood perfusion device for treating pesticide poisoning according to claim 7, characterized in that: The bottom of the second slider is fixedly connected to a second guide block, the inside of the second guide block is slidably connected to a second guide rail, the bottom of the second guide rail is fixedly connected to a support rod, and the support rod is fixedly connected inside the placement box.

9. The blood perfusion device for treating pesticide poisoning according to claim 2, characterized in that: The drug injection mechanism includes a speed-regulating motor installed inside the housing. The output end of the speed-regulating motor is fixedly connected to a drive gear. A driven gear meshes between the teeth of the drive gear. A limiting member is rotatably connected to the bottom of the driven gear. The limiting member is fixedly connected to one end of the housing. A third lead screw is slidably connected inside the driven gear. The bottom of the third lead screw contacts a syringe. A connecting tube is fixedly connected to one end of the syringe. One end of the connecting tube is snapped into the inside of a Y-shaped tube.

10. The blood perfusion device for treating pesticide poisoning according to claim 1, characterized in that: A display panel is provided on the top of one end of the casing, and a button panel is provided on the side of the casing near the display panel.

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