Skin biopsy sampling device and use method thereof

Abstract

The invention discloses a skin biopsy sampling device, and belongs to the technical field of medical apparatuses and instruments, the skin biopsy sampling device comprises two height-adjustable mounting racks, spring telescopic rods are mounted on the two mounting racks, L-shaped fixing rods are fixed to one ends of the spring telescopic rods, a positioning ring is fixed to the bottom ends of the two fixing rods, and the positioning ring is fixed to the bottom ends of the spring telescopic rods. A sampling mechanism is placed between the two fixing rods, a piston sampling barrel is movably arranged on the sampling mechanism, an annular cutter is fixed at the bottom end of the piston sampling barrel, and scales are arranged on the side wall of the piston sampling barrel; during sampling, the operation is simple, the precision is high, the precooling function is achieved, the sensitivity of skin nerve endings is directly reduced through low temperature, the discomfort of a patient is relieved, automatic gauze replacement can be synchronously achieved, brand new gauze is used for making contact with the skin during sampling each time, the risks of bacterial residues and cross infection are thoroughly avoided, and the device is suitable for multiple times of sampling.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a skin biopsy sampling device and its usage method. Background Technology

[0002] Skin biopsy is the core means of clinical diagnosis of skin diseases (such as inflammatory skin diseases, pigmentary diseases, and skin tumors), and it is also the "gold standard" for clarifying the pathological classification and depth of invasion of malignant skin tumors (such as melanoma and basal cell carcinoma). Its diagnostic results directly determine the formulation of subsequent treatment plans and have an irreplaceable position in the dermatology diagnosis and treatment system.

[0003] Currently, the routine procedures for skin biopsy sampling in clinical practice still have significant technical limitations, mainly reflected in the dual deficiencies of operational complexity and patient comfort. On the one hand, the sampling process requires doctors to first use instruments such as scalpels and trephine drills to cut tissue. During the operation, the depth and range of the cutting must be precisely controlled to obtain qualified cylindrical or sheet-like tissue samples. The overall operation steps are cumbersome and time-consuming. Moreover, in primary healthcare institutions or emergency treatment scenarios, the frequent switching of tools can easily reduce operational efficiency.

[0004] On the other hand, in order to reduce the pain of the procedure, clinical practice has gradually adopted microneedle anesthesia technology to replace traditional subcutaneous injection anesthesia. This technology uses a microneedle array to penetrate local anesthetics into the skin surface, reducing the intense pain caused by needle puncture. However, in practice, this anesthesia method still has unavoidable drawbacks: First, when the microneedle array punctures the skin surface, even though the needles are extremely fine, it will still mechanically stimulate the nerve endings in the skin, causing some sensitive patients to experience "instantaneous stinging pain similar to a mosquito bite." This pain occurs before the anesthetic takes effect, becoming the primary source of discomfort during the anesthesia process. Second, there is a "time lag" of several seconds between the release of the anesthetic from the microneedle and its penetration into the nerve endings in the dermis to completely block the pain signal. If the rhythm of the operation is not properly controlled, the cutting may be started before the anesthetic has taken full effect, resulting in the patient perceiving a weak pain. Third, there are individual differences in the sensitivity of different patients to anesthetics. Even if some patients receive microneedle anesthesia, they may still experience slight discomfort from skin traction and tissue separation during the subsequent cutting process. Although the residual pain is relatively mild, it can still exacerbate the psychological fear of patients (especially children and elderly patients) regarding biopsy procedures and even affect their cooperation. Summary of the Invention

[0005] The purpose of this invention is to provide a skin biopsy sampling device and its usage method, which solves the following technical problems: existing skin biopsy sampling requires a high level of skill from doctors, and the use of microneedles alone is cumbersome and insufficient to completely eliminate the patient's pain.

[0006] The objective of this invention can be achieved through the following technical solutions: A skin biopsy sampling device and its method of use include two height-adjustable mounting brackets. Each mounting bracket is equipped with a spring telescopic rod. One end of each spring telescopic rod is fixed with an L-shaped fixing rod. The bottom ends of both fixing rods are jointly fixed with a positioning ring. A sampling mechanism is placed between the two fixing rods. A piston sampling cylinder is movably mounted on the sampling mechanism. A ring cutter is fixed to the bottom end of the piston sampling cylinder. Scales are provided on the side wall of the piston sampling cylinder. The positioning ring has a notch on one side, and the cooling box is slidably connected to the notch through the sliding grooves on both sides. The bottom wall of the cooling box has an opening on one side, and an opening is provided on one side wall of the cooling box. An unwinding drum and a winding drum are installed at the opening, and ratchet wheels are installed on both sides of the winding drum. Both mounting brackets are fixed with L-shaped connecting rods, and one end of each connecting rod is fixed with a connecting column. A fixing plate is fixed to one side of the connecting column, and one end of the fixing plate extends into the opening of the cooling box. The upper surface of the fixing plate is provided with ratchet teeth that match the ratchet. A driving mechanism is provided between the cooling box and the sampling mechanism, which pushes the cooling box to move horizontally when the sampling mechanism descends.

[0007] As a further aspect of the present invention: the sampling mechanism includes a cylindrical body with an open bottom, a piston sampling cylinder movably disposed on the top wall of the cylindrical body, a fixing block symmetrically disposed at the bottom of the cylindrical body, an insertion rod fixed on the lower surface of the fixing block, an insertion hole matching the insertion rod being opened on the fixing rod, and a rubber ring being fitted on the insertion rod.

[0008] As a further aspect of the present invention: a fixing ring is fixed on the piston sampling cylinder, a first spring is connected between the fixing ring and the top wall of the cylinder, a piston rod is provided inside the piston sampling cylinder, a piston is provided at the bottom end of the piston rod, and a handle is provided on the piston sampling cylinder.

[0009] As a further aspect of the present invention: the driving mechanism includes a first wedge block fixed on the piston sampling cylinder, and a second wedge block fixed on the top wall of the cooling box by a column, wherein the first wedge block and the second wedge block are in contact.

[0010] As a further embodiment of the present invention: a disinfectant container is fixed to the top of the connecting column, a drive rod is fixed between the disinfectant container and the column, a liquid outlet hose is connected to the bottom wall of the disinfectant container, a spray pipe is fixed to one end of the cooling box near the opening, multiple nozzles are symmetrically arranged on the spray pipe, one end of the liquid outlet hose is connected to the spray pipe, a piston plate is provided inside the disinfectant container, and a pressure valve is installed on the liquid outlet hose.

[0011] As a further aspect of the present invention: the drive rod includes a cylinder, an air outlet pipe is connected between the cylinder and the disinfectant container, an air inlet pipe is also connected to the cylinder, a one-way valve is provided on both the air outlet pipe and the air inlet pipe, a movable rod is movably provided at the end of the cylinder away from the air outlet pipe, one end of the movable rod is connected to a column, and a sealing push block is fixed at the other end, and a second spring is connected between the sealing push block and the inner wall of the cylinder.

[0012] As a further embodiment of the present invention: the mounting frame includes a base, a vertical pole is fixed on the base, a lifting rod is movably mounted on the vertical pole, a spring telescopic rod is fixed on the lifting rod, one end of the connecting rod is fixedly connected to the lifting rod, and a plurality of pads are provided between the lifting rod and the base.

[0013] A method of using a skin biopsy sampling device includes the following steps: S1. Wrap gauze around the unwinding drum, the gauze is multi-layered, and place an ice pack in the cooling box, with the ice pack at the opening. One end of the gauze is wrapped around the ice pack and connected to the take-up drum. S2. Place the mounting frame and adjust the height of the positioning ring so that it is positioned around the skin to be sampled. Extend the ice pack from the opening and apply the ice pack to the sampling site through the gauze to cool and relieve pain. At this time, the doctor will carry out other preparations. S3. After preparation, the doctor first administers microneedle anesthesia to the patient, then pushes the piston sampling cylinder down. Under the action of the drive mechanism, the cooling box moves away from the sampling site. Subsequently, the circumferential cutter completes the sampling, and the skin sample is sucked into the piston sampling cylinder through negative pressure to complete the sampling.

[0014] The beneficial effects of this invention are: (1) The present invention pre-cools the sampling site with ice packs, and uses low temperature to directly reduce the sensitivity of skin nerve endings. This not only completely covers the "instantaneous stinging pain" before microneedle puncture, but also delays skin tissue metabolism, prolongs the onset time and intensity of subsequent microneedle anesthetic, completely eliminates the slight pain caused by poor anesthetic onset and individual sensitivity, minimizes the discomfort throughout the sampling process, and greatly alleviates the psychological fear of patients (especially children and elderly sensitive people) regarding biopsy. (2) The gauze on the outside of the ice pack of the present invention forms a buffer layer to avoid direct contact between the ice pack and the skin, which not only ensures the "low temperature analgesia" effect (maintains the skin temperature in the safe analgesia range), but also prevents complications such as frostbite and redness caused by the low temperature of the ice pack, thus taking into account both the analgesic effect and the safety of use. (3) The present invention can realize the automatic replacement of gauze at the same time. Each sampling uses a brand new gauze to contact the skin, which completely avoids the risk of bacterial residue and cross-infection. It is especially suitable for the multiple sampling needs of patients with multiple skin lesions. Doctors do not need to frequently disinfect or prepare new analgesia tools between multiple samplings. They can quickly start the next sampling by using the automatic switching function of the device, which improves the operational efficiency in the scenario of multiple patients receiving centralized treatment. Attached Figure Description

[0015] The invention will now be further described with reference to the accompanying drawings.

[0016] Figure 1 This is a first-view structural diagram of the entire invention; Figure 2 This is a second-view structural diagram of the entire invention; Figure 3 This is a schematic diagram of the internal structure of the cylinder of the present invention; Figure 4 This is a first-view structural schematic diagram of the positioning ring and cooling box of the present invention; Figure 5 This is a second-view structural schematic diagram of the positioning ring and cooling box of the present invention; Figure 6 This is a three-dimensional structural diagram of the cooling box of the present invention; Figure 7 This is a schematic diagram of the internal structure of the cooling box of the present invention; Figure 8 This is a schematic diagram of the internal structure of the disinfectant box and the drive rod of the present invention; Figure 9 This is a schematic diagram of the mounting bracket of the present invention.

[0017] In the diagram: 1. Mounting bracket; 101. Base; 102. Upright pole; 103. Lifting rod; 104. Pad; 2. Spring telescopic rod; 3. Fixing rod; 4. Positioning ring; 5. Sampling mechanism; 501. Cylinder; 502. Fixing block; 503. Insertion rod; 504. Piston sampling cylinder; 505. Fixing ring; 506. Ring cutter; 507. First spring; 508. Piston rod; 6. Cooling box; 601. Opening; 602. Slide groove; 603. Unwinding drum; 60 4. Rewind drum; 605. Ratchet; 7. First wedge block; 8. Column; 9. Second wedge block; 10. Connecting rod; 11. Connecting column; 12. Fixing plate; 13. Ratchet tooth; 14. Disinfectant container; 1401. Piston plate; 15. Drive rod; 1501. Cylinder; 1502. Movable rod; 1503. Sealing push block; 1504. Second spring; 1505. Air outlet pipe; 1506. Air inlet pipe; 16. Liquid outlet hose; 17. Spray pipe; 18. Nozzle.

[0018] The accompanying drawings are for illustrative purposes only and should not be construed as limiting the invention. To better illustrate this embodiment, some parts in the drawings may be omitted, enlarged, or reduced, and do not represent the actual size and shape of the product. It is understandable to those skilled in the art that some well-known structures and their descriptions may be omitted in the drawings. Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] Please see Figures 1 to 6As shown, this invention is a skin biopsy sampling device, comprising two height-adjustable mounting brackets 1, each mounting bracket 1 having a spring telescopic rod 2. One end of each spring telescopic rod 2 is fixed with an L-shaped fixing rod 3. The bottom ends of both fixing rods 3 are jointly fixed with a positioning ring 4. A sampling mechanism 5 is placed between the two fixing rods 3. A piston sampling cylinder 504 is movably mounted on the sampling mechanism 5. A ring cutter 506 is fixed to the bottom end of the piston sampling cylinder 504. Graduation is provided on the side wall of the piston sampling cylinder 504. A notch is provided on one side of the positioning ring 4. A cooling box 6 is also included. The cooling box 6 is slidably connected to the notch via the sliding grooves 602 on both sides. An opening 601 is provided on one side of the bottom wall of the cooling box 6, and an vent is provided on one side wall of the cooling box 6. A unwinding drum 603 and a winding drum 604 are installed at the vent. Ratchets 605 are installed on both sides of the winding drum 604. L-shaped connecting rods 10 are fixed to both mounting brackets 1. A connecting post 11 is fixed to one end of both connecting rods 10. A fixing plate 12 is fixed to one side of the connecting post 11, and one end of the fixing plate 12 extends into the vent of the cooling box 6. The upper surface of the fixing plate 12 is provided with… A ratchet 13 is adapted to the ratchet 605. A drive mechanism is provided between the cooling box 6 and the sampling mechanism 5. When the sampling mechanism 5 descends, it pushes the cooling box 6 to move horizontally. An ice pack is placed inside the cooling box 6, located at the opening 601. Gauze is wrapped around the unwinding drum 603. The gauze is multi-layered, with one end of the gauze passing over the ice pack and connecting to the take-up drum 604. At this time, the gauze is located outside the ice pack. The mounting bracket 1 is placed and its height is adjusted so that the positioning ring 4 is located at the patient's sampling site. The ice pack and gauze pre-cool the sampling site through the opening 601. At this time, the doctor can perform preoperative preparations. After cooling for a period of time, microneedle anesthesia is performed, and then the piston sampling cylinder 504 is pushed downward. Under the action of the drive mechanism, the cooling box 6 automatically moves away from the sampling point. Then, the sampling is completed by the circumferential cutter 506, and the sample is sucked into the piston sampling cylinder 504 by negative pressure. Currently, conventional operation requires the use of scalpels, trephines and other tools for cutting. After cutting, the sample is removed with tweezers. The operation steps are cumbersome and heavily rely on the operator's experience and skills. This application is simple to operate, easy to cut and sample, easy to learn, and does not require much experience and skills from the operator. During the movement of the cooling box 6, the winding drum 604 rotates under the action of the ratchet 605 and the ratchet 13, winding up the used gauze and moving the unused gauze to the outside of the ice pack. During multiple sampling, the doctor does not need to frequently disinfect or prepare new analgesic tools between sampling intervals, improving work efficiency. At this time, the fixing plate 12 enters the cooling box 6, blocking the opening 601 to prevent the ice pack from contacting other parts of the skin and causing discomfort to the patient. It is worth noting that the ratchet 13 can deflect. When the cooling box 6 is away from the sampling point, the ratchet 13 is fixed, thereby causing the ratchet 605 to rotate. When the cooling box 6 is reset, the ratchet 13 deflects, and the ratchet 605 cannot rotate. The cooperation between the ratchet 605 and the ratchet 13 is existing technology, and its specific structure will not be described in detail here.

[0021] See Figures 1 to 3 The sampling mechanism 5 includes a cylindrical body 501 with an open bottom, a piston sampling cylinder 504 movably mounted on the top wall of the cylindrical body 501, and fixing blocks 502 symmetrically arranged at the bottom of the cylindrical body 501. An insertion rod 503 is fixed to the lower surface of the fixing block 502, and the fixing rod 503 has a matching insertion hole. A rubber ring is fitted onto the insertion rod 503. A fixing ring 505 is fixed to the piston sampling cylinder 504, and a first spring 505 connects the fixing ring 505 to the top wall of the cylindrical body 501. 07. A piston rod 508 is provided inside the piston sampling cylinder 504, and a piston is provided at the bottom end of the piston rod 508. A handle is provided on the piston sampling cylinder 504. The insertion rod 503 is inserted into the insertion hole on the fixing rod 3 to fix the cylinder 501. The rubber ring is used to increase stability. After one sampling is completed, the cylinder 501 can be directly removed to obtain the sample. Then, a new cylinder 501 can be replaced to quickly carry out the next sampling. The cylinder 501 and its internal mechanism can be reused after disinfection.

[0022] See Figures 2 to 4 The driving mechanism includes a first wedge block 7 fixed on the piston sampling cylinder 504, and a second wedge block 9 fixed on the top wall of the cooling box 6 by a column 8. The first wedge block 7 and the second wedge block 9 are in contact. When sampling, the piston sampling cylinder 504 is pushed down. Under the action of the first wedge block 7 and the second wedge block 9, the cooling box 6 automatically moves away from the sampling point.

[0023] See Figures 3 to 8A disinfectant container 14 is fixed to the top of the connecting column 11. A drive rod 15 is fixed between the disinfectant container 14 and the column 8. A discharge hose 16 is connected to the bottom wall of the disinfectant container 14. A spray pipe 17 is fixed to the end of the cooling box 6 near the opening. Multiple nozzles 18 are symmetrically arranged on the spray pipe 17. One end of the discharge hose 16 is connected to the spray pipe 17. A piston plate 1401 is provided inside the disinfectant container 14. A pressure valve is installed on the discharge hose 16. The drive rod 15 includes a cylinder 1501. An air outlet pipe 1505 is connected between the cylinder 1501 and the disinfectant container 14. An air inlet pipe 1506 is also connected to the cylinder 1501. Both the air outlet pipe 1505 and the air inlet pipe 1506 are equipped with one-way valves. A movable rod 1502 is movably installed at one end away from the air outlet pipe 1505. One end of the movable rod 1502 is connected to the column 8, and the other end is fixed with a sealing push block 1503. A second spring 1504 is connected between the sealing push block 1503 and the inner wall of the cylinder 1501. In order to avoid bacterial infection, when the cooling box 6 moves, the column 8 pushes the movable rod 1502 and the sealing push block 1503 to move, thereby sending the air in the cylinder 1501 into the disinfectant box 14 through the air outlet pipe 1505. Under the action of air pressure, the piston plate 1401 is pushed, thereby squeezing out the disinfectant. The disinfectant enters the spray pipe 17 through the liquid outlet hose 16, and then is sprayed onto the gauze through the nozzle 18 to disinfect the used and unused gauze.

[0024] See Figure 1 and Figure 9 The mounting frame 1 includes a base 101, a vertical rod 102 fixed on the base 101, a lifting rod 103 movably mounted on the vertical rod 102, a spring telescopic rod 2 fixed on the lifting rod 103, one end of a connecting rod 10 fixedly connected to the lifting rod 103, and multiple pads 104 provided between the lifting rod 103 and the base 101. By adjusting the number of pads 104, the height of the lifting rod 103 can be adjusted, thereby adjusting the height of the positioning ring 4 to adapt to different people and different parts of the patient. A suction cup can be added to the bottom of the base 101 to improve the overall placement stability.

[0025] A method of using a skin biopsy sampling device includes the following steps: S1. Wrap gauze around the unwinding drum 603. The gauze is multi-layered. Place an ice pack in the cooling box 6. The ice pack is located at the opening 601. One end of the gauze is wrapped around the ice pack and connected to the take-up drum 604. S2. Place the mounting frame 1, adjust the height of the positioning ring 4 so that it is located around the skin to be sampled, extend the ice pack from the opening 601, and use the ice pack through the gauze to cool and relieve pain at the sampling site. At this time, the doctor will carry out other preparations. S3. After preparation, the doctor first administers microneedle anesthesia to the patient, then pushes the piston sampling cylinder 504 down. Under the action of the drive mechanism, the cooling box 6 moves away from the sampling site. Subsequently, the circumferential cutter 506 completes the sampling and uses negative pressure to draw the skin sample into the piston sampling cylinder 504 to complete the sampling.

[0026] The working principle of this invention is as follows: First, the overall height is adjusted by adjusting the number of pads 104 between the lifting rod 103 and the base 101 in the mounting frame 1, so that the positioning ring 4 at the bottom of the fixing rod 3 is accurately aligned with the patient's sampling site. The positioning ring 4 is attached to the patient's skin and located around the sampling site. At the same time, the cylinder 501 of the sampling mechanism 5 is fixed by inserting the insertion rod 503 of the bottom fixing block 502 into the insertion hole of the fixing rod 3. The cooling box 6 is slidably connected to the notch of the positioning ring 4 through the sliding groove 602. The ice pack placed in the box corresponds to the position of the opening 601. The multi-layer gauze on the roll 603 is wrapped around the ice pack and connected to the take-up roll 604 to form an "ice pack-gauze" buffer layer to pre-cool the sampling site to reduce the sensitivity of nerve endings (simultaneously facilitating the doctor's preoperative preparation and subsequent microneedle anesthesia). During sampling, the doctor pushes the piston sampling cylinder 504 downwards. Scales are added to the side wall of the piston sampling cylinder 504 to facilitate knowing the sampling depth. The first wedge block 7 on the piston sampling cylinder 504 contacts the second wedge block 9 on the top wall column 8 of the cooling box 6 and generates a horizontal thrust, causing the cooling box 6 to automatically move away from the sampling site. Subsequently, the piston sampling cylinder 504 continues to move downwards, causing the circumcision blade 506 to cut into the skin and rotate appropriately. The piston rod 508 is pulled, and negative pressure is generated through the piston to draw the tissue sample into the piston sampling cylinder 504 (the first spring 507 between the fixing ring 505 and the top wall of the cylinder 501 assists in repositioning). The sampling process combines a dual-modal analgesia scheme of physical cooling and pre-anesthesia, effectively eliminating pain during the cutting process and improving patient comfort. During the translation of the cooling box 6, the ratchet 605 on both sides of its take-up drum 604 engages with the ratchet 13 (fixed at this time) on the fixed plate 12, which drives the take-up drum 604 to take up the used gauze and the unwinding drum 603 to release the new gauze (when the cooling box 6 is reset, the ratchet 13 deflects to prevent the gauze from retracting). At the same time, the column 8 pushes the movable rod 1502 of the drive rod 15, so that the sealing push block 1503 compresses air in the cylinder 1501 and sends it into the disinfectant box 14 through the air outlet pipe 1505. The air pressure pushes the piston plate 1401 to press the disinfectant into the spray pipe 17 through the liquid outlet hose 16, and then sprays it onto the gauze through the nozzle 18 to complete the synchronous disinfection. After sampling is completed, the piston sampling cylinder 504 automatically resets under the action of the first spring 507, and the movable rod 1502 and cooling box 6 also automatically reset under the action of the second spring 1504. When the movable rod 1502 resets, external air enters the cylinder 1501 through the air inlet pipe 1506, which is convenient for subsequent use. Then, the sample in the piston sampling cylinder 504 can be taken out by pulling out the cylinder body 501. The next sampling can be carried out by replacing the new piston sampling cylinder 504, which significantly reduces the cost of single use and is easy to promote.

[0027] The foregoing has provided a detailed description of one embodiment of the present invention, but this description is merely a preferred embodiment and should not be construed as limiting the scope of the invention. All equivalent variations and modifications made within the scope of the claims of this invention should still fall within the patent coverage of this invention.

Claims

1. A skin biopsy sampling device, comprising two height-adjustable mounting brackets (1), each of the two mounting brackets (1) being equipped with a spring telescopic rod (2), one end of each spring telescopic rod (2) being fixed with an L-shaped fixing rod (3), and the bottom ends of the two fixing rods (3) being jointly fixed with a positioning ring (4), characterized in that, A sampling mechanism (5) is placed between the two fixed rods (3). A piston sampling cylinder (504) is movably mounted on the sampling mechanism (5). A ring cutter (506) is fixed at the bottom of the piston sampling cylinder (504). A scale is provided on the side wall of the piston sampling cylinder (504). The positioning ring (4) has a notch on one side. The cooling box (6) is slidably connected to the notch through the sliding grooves (602) on both sides. The bottom wall of the cooling box (6) has an opening (601) on one side. The side wall of the cooling box (6) has an open opening. A unwinding drum (603) and a winding drum (604) are installed at the open opening. Ratchets (605) are installed on both sides of the winding drum (604). Both mounting brackets (1) are fixed with L-shaped connecting rods (10), and one end of the two connecting rods (10) is fixed with a connecting post (11). A fixing plate (12) is fixed on one side of the connecting post (11), and one end of the fixing plate (12) extends into the opening of the cooling box (6). The upper surface of the fixing plate (12) is provided with ratchet teeth (13) that are compatible with the ratchet (605). A driving mechanism is provided between the cooling box (6) and the sampling mechanism (5). When the sampling mechanism (5) descends, it pushes the cooling box (6) to move horizontally.

2. The skin biopsy sampling device according to claim 1, characterized in that, The sampling mechanism (5) includes a cylindrical body (501) with an open bottom. The piston sampling cylinder (504) is movably disposed on the top wall of the cylindrical body (501). Fixed blocks (502) are symmetrically disposed at the bottom of the cylindrical body (501). An insertion rod (503) is fixed on the lower surface of the fixed block (502). An insertion hole matching the insertion rod (503) is opened on the fixed rod (3). A rubber ring is sleeved on the insertion rod (503).

3. The skin biopsy sampling device according to claim 2, characterized in that, A fixing ring (505) is fixed on the piston sampling cylinder (504), and a first spring (507) is connected between the fixing ring (505) and the top wall of the cylinder (501). A piston rod (508) is provided inside the piston sampling cylinder (504), and a piston is provided at the bottom end of the piston rod (508). A handle is provided on the piston sampling cylinder (504).

4. The skin biopsy sampling device according to claim 1, characterized in that, The drive mechanism includes a first wedge block (7) fixed on the piston sampling cylinder (504), and a second wedge block (9) fixed on the top wall of the cooling box (6) by a column (8), wherein the first wedge block (7) and the second wedge block (9) are in contact.

5. A skin biopsy sampling device according to claim 4, characterized in that, A disinfectant container (14) is fixed to the top of the connecting column (11). A drive rod (15) is fixed between the disinfectant container (14) and the column (8). A liquid outlet hose (16) is connected to the bottom wall of the disinfectant container (14). A spray pipe (17) is fixed to one end of the cooling box (6) near the opening. Multiple nozzles (18) are symmetrically arranged on the spray pipe (17). One end of the liquid outlet hose (16) is connected to the spray pipe (17). A piston plate (1401) is provided inside the disinfectant container (14). A pressure valve is installed on the liquid outlet hose (16).

6. A skin biopsy sampling device according to claim 5, characterized in that, The drive rod (15) includes a cylinder (1501), and an air outlet pipe (1505) is connected between the cylinder (1501) and the disinfectant box (14). An air inlet pipe (1506) is also connected to the cylinder (1501). A one-way valve is provided on both the air outlet pipe (1505) and the air inlet pipe (1506). A movable rod (1502) is movably provided at one end of the cylinder (1501) away from the air outlet pipe (1505). One end of the movable rod (1502) is connected to the column (8), and a sealing push block (1503) is fixed at the other end. A second spring (1504) is connected between the sealing push block (1503) and the inner wall of the cylinder (1501).

7. A skin biopsy sampling device according to claim 1, characterized in that, The mounting bracket (1) includes a base (101), a vertical rod (102) is fixed on the base (101), a lifting rod (103) is movably arranged on the vertical rod (102), a spring telescopic rod (2) is fixed on the lifting rod (103), one end of the connecting rod (10) is fixedly connected to the lifting rod (103), and a plurality of pads (104) are provided between the lifting rod (103) and the base (101).

8. The method of using the skin biopsy sampling device according to claim 1, characterized in that, Includes the following steps: S1. Wrap gauze around the unwinding drum (603). The gauze is multi-layered. Place an ice pack in the cooling box (6). The ice pack is located at the opening (601). One end of the gauze is wrapped around the ice pack and connected to the take-up drum (604). The doctor first performs microneedle anesthesia on the patient. S2. Place the mounting bracket (1) and adjust the height of the positioning ring (4) so ​​that it is located around the skin to be sampled. The ice pack extends out from the opening (601) and cools and relieves pain at the sampling site through the gauze. At this time, the doctor performs other preparatory work. S3. After preparation, the doctor pushes the piston sampling cylinder (504) down. Under the action of the driving mechanism, the cooling box (6) moves away from the sampling site. Then the circumcision knife (506) completes the sampling and the skin sample is sucked into the piston sampling cylinder (504) by negative pressure to complete the sampling.

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