Interventional devices and medical apparatus for implanting electrodes into the brain through blood vessels

Abstract

The present disclosure relates to an interventional device for implanting an electrode into a brain through a blood vessel having a blood vessel passage and a blood vessel wall, characterized in that the interventional device comprises: a first guide, a distal end of which is movable distally within the blood vessel passage and establishes a first support point in the blood vessel passage; a second guide, a distal end of which is movable distally within the blood vessel passage through the first guide and establishes a second support point in the blood vessel passage, such that the second guide extends arcuately between the first support point and the second support point; and a puncture set for carrying the electrode, and a distal end of which is movable distally within the blood vessel passage through the first guide and punctures the blood vessel wall in a target puncture region between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical device.

Description

[0001] This application is a divisional application of the invention patent application with application number 202210697115.5, application date June 20, 2022, entitled "Interventional device and medical device for implanting electrodes into the brain via blood vessels". Technical Field

[0002] This disclosure relates to the field of medical devices, and more specifically, to an interventional device for implanting electrodes into the brain via blood vessels and a medical device. Background Technology

[0003] In the field of brain-computer interface technology, electrodes (such as flexible electrode wires) are widely used. Electrodes can be implanted into the brain to collect signals from neurons in the vicinity of the electrode. Current solutions for implanting electrodes in the brain involve first surgically creating a window in the skull to open the dura mater and expose the target implantation area on the cerebral cortex, then implanting the electrode mechanically or manually. However, this solution inevitably leads to damage to nerve cells in the non-target area, and may even cause brain injury, when the target area is a deep functional region of the brain rather than the cortex. Therefore, it is necessary to find a new solution for implanting electrodes into the brain, especially deep brain regions. Summary of the Invention

[0004] A brief overview of this disclosure is given below to provide a basic understanding of some aspects of it. However, it should be understood that this overview is not an exhaustive summary of this disclosure. It is not intended to identify key or essential parts of this disclosure, nor is it intended to limit the scope of this disclosure. Its purpose is merely to present certain concepts of this disclosure in a simplified form as a prelude to the more detailed description that follows.

[0005] According to a first aspect of this disclosure, an interventional device is provided for implanting an electrode into the brain via a blood vessel having a vascular channel and a vascular wall, wherein the interventional device comprises: a first guide, the distal end of which is movable distally within the vascular channel and establishes a first support point within the vascular channel; a second guide, the distal end of which is movable distally within the vascular channel through the first guide and establishes a second support point within the vascular channel, such that the second guide extends arcuately between the first support point and the second support point; and a puncture kit for carrying the electrode, the distal end of which is movable distally within the vascular channel through the first guide and punctures the vascular wall in a target puncture region between the first support point and the second support point, thereby implanting the carried electrode into the brain.

[0006] According to a second aspect of this disclosure, an interventional device is provided for implanting an electrode into the brain via a blood vessel, the blood vessel including a first blood vessel segment and a second blood vessel segment extending in different directions, characterized in that the interventional device comprises: a first guide, the distal end of which is movable distally within a vascular channel of the first blood vessel segment to reach a first position, the first position being located in the first blood vessel segment and near the junction of the first blood vessel segment and the second blood vessel segment; a second guide, the distal end of which is movable distally within the first guide and continues to move distally after reaching the distal end of the first guide to pass through the junction of the first blood vessel segment and the second blood vessel segment and enter the second blood vessel segment, thereby reaching and fixing at a second position; and a puncture kit for carrying the electrode, the distal end of which is movable distally within the first guide and continues to move distally after reaching the distal end of the first guide to puncture the blood vessel wall between the first position and the second position, thereby implanting the carried electrode into the brain.

[0007] According to a third aspect of this disclosure, an interventional device is provided for implanting an electrode into the brain via a blood vessel, wherein the blood vessel includes a first blood vessel segment and a second blood vessel segment connected and extending in different directions, the connection point of the first blood vessel segment and the second blood vessel segment being near the brain, the interventional device comprising: a first catheter configured such that its distal end can reach and float at a first position located in the first blood vessel segment, and the opening of the distal end of the first catheter is substantially oriented in a first direction, the first position being located near the connection point, the first direction being the direction in which the first blood vessel segment extends near the connection point; a stent assembly including a stent located at a distal end and a stent push rod connected to the stent, the stent assembly being configured such that the stent can reach the distal end of the first catheter along the lumen of the first catheter, pass through the connection point and enter the second blood vessel segment, and be fixed at a second position located in the second blood vessel segment such that the stent push rod is positioned at the connection point. The first position and the second position extend along the branching direction of the blood vessel, and the opening at the distal end of the first catheter is deflected in a second direction by the action of the stent push rod, the second direction being the direction in which the second blood vessel segment extends near the connection point; a third catheter, the third catheter being configured such that its distal end can reach and extend from the distal end of the first catheter along the lumen to approach the puncture site on the blood vessel wall; and a puncture kit, the puncture kit being used to carry the electrode, the puncture kit being configured such that its distal end can approach the distal end of the third catheter along the lumen of the third catheter, wherein the third catheter is further configured such that after the distal end of the puncture kit approaches the distal end of the third catheter, the distal end of the third catheter can puncture the blood vessel wall at the puncture site and reach outside the blood vessel but not into the brain, the puncture kit is further configured such that after the distal end of the third catheter reaches outside the blood vessel, it continues to move along the lumen of the third catheter and passes through the distal end of the third catheter to enter the brain, thereby implanting the carried electrode into the brain.

[0008] According to a fourth aspect of this disclosure, an interventional device is provided for implanting an electrode into the brain via a blood vessel, wherein the blood vessel includes a first blood vessel segment and a second blood vessel segment connected and extending in different directions, the connection point of the first blood vessel segment and the second blood vessel segment being near the brain, the interventional device comprising: a first catheter configured such that its distal end can reach and be located at a first position within the first blood vessel segment, the first position being near the connection point; and a stent assembly including a stent located at a distal end and a stent push rod connected to the stent, the stent assembly being configured such that the stent can reach the distal end of the first catheter along the lumen of the first catheter and pass through the connection point. The stent is inserted into a second vascular segment and fixed at a second position within the second vascular segment, such that the stent pusher extends between the first and second positions; a second catheter is configured to fit over the stent pusher and its distal end can reach and be located at a specific position between the first and second positions; and a puncture kit is used to carry an electrode, the puncture kit being configured such that its distal end can reach the distal end of the second catheter along the lumen of the second catheter and continue to travel after passing the distal end of the second catheter to puncture the vascular wall at a puncture site corresponding to the specific position and enter the brain, thereby implanting the carried electrode into the brain.

[0009] According to a fifth aspect of this disclosure, an interventional device is provided for implanting an electrode into the brain via a blood vessel, wherein the blood vessel includes a first blood vessel segment and a second blood vessel segment connected and extending in different directions, the connection point of the first blood vessel segment and the second blood vessel segment being near the brain, the interventional device comprising: a first catheter configured such that its distal end can reach and float at a first position located in the first blood vessel segment, and the opening of the distal end of the first catheter is substantially oriented in a first direction, the first position being located near the connection point, the first direction being the direction in which the first blood vessel segment extends near the connection point; and a stent assembly including a stent located at a distal end and a stent pusher connected to the stent, the stent assembly being configured to The stent is capable of reaching the distal end of the first catheter along the lumen of the first catheter and entering the second vascular segment through the connection point, and is fixed at a second position in the second vascular segment such that the stent push rod extends along the branching direction of the blood vessel between the first position and the second position, and the opening at the distal end of the first catheter is deflected in a second direction by the action of the stent push rod, the second direction being the direction in which the second vascular segment extends near the connection point; and an electrode guide needle, the distal end of which is configured to carry an electrode, the electrode guide needle being configured such that its distal end can reach and extend from the distal end of the first catheter along the lumen of the first catheter, pass through the blood vessel wall at a puncture site on the blood vessel wall to enter the brain, thereby implanting the carried electrode into the brain.

[0010] According to a sixth aspect of this disclosure, a medical device is provided, the medical device comprising an interventional device according to this disclosure for implanting electrodes into the brain via blood vessels.

[0011] Other features and advantages of this disclosure will become clearer from the following detailed description of exemplary embodiments with reference to the accompanying drawings. Attached Figure Description

[0012] The accompanying drawings, which form part of this specification, illustrate embodiments of the present disclosure and, together with the specification, serve to explain the principles of the disclosure. The embodiments set forth in the drawings are illustrative and exemplary in nature and are not intended to limit the scope of the disclosure. The following detailed description of exemplary embodiments will be clearly understood when read in conjunction with the following drawings, wherein similar structures are indicated by similar l, and wherein:

[0013] Figure 1 It is a schematic perspective view of the human brain;

[0014] Figure 2 This is a perspective view schematically illustrating an interventional device for implanting electrodes into the brain via blood vessels, according to one or more exemplary embodiments of the present disclosure.

[0015] Figure 3 This is a schematic perspective view of an interventional device for implanting electrodes into the brain via blood vessels, according to one or more exemplary embodiments of the present disclosure, wherein the electrodes have been implanted into the brain.

[0016] Figures 4A to 4C Three example electrode guide needles for an interventional device for implanting electrodes into the brain via blood vessels, according to one or more exemplary embodiments of the present disclosure, are shown respectively;

[0017] Figures 5A to 5C Three example occluders for an interventional device for implanting electrodes into the brain via blood vessels, according to one or more exemplary embodiments of the present disclosure, are shown respectively.

[0018] Figures 6A to 6G This is a schematic diagram illustrating the use of an interventional device for implanting electrodes into the brain via blood vessels, according to one or more exemplary embodiments of the present disclosure.

[0019] Figures 7A to 7F This is a schematic diagram illustrating the use of an interventional device for implanting electrodes into the brain via blood vessels, according to one or more exemplary embodiments of the present disclosure.

[0020] Figure 8A and Figure 8B This is a schematic diagram illustrating a puncture kit according to an embodiment of the present disclosure. Detailed Implementation

[0021] Various exemplary embodiments of the present disclosure will now be described in detail with reference to the accompanying drawings. It should be noted that, unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the present disclosure.

[0022] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the scope of this disclosure or its application or use. That is, the structures and methods herein are shown in an exemplary manner to illustrate different embodiments of the structures and methods in this disclosure. However, those skilled in the art will understand that they merely illustrate exemplary ways that can be used to implement this disclosure, and not exhaustive ways. Furthermore, the drawings are not necessarily drawn to scale, and some features may be enlarged to show details of specific components.

[0023] In addition, techniques, methods and equipment known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods and equipment should be considered part of the specification.

[0024] In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values.

[0025] Figure 1 The illustration shows the human brain.

[0026] like Figure 1 As shown in this disclosure, for ease of explanation of the technical solution, the human brain is schematically divided into superficial brain regions 1, located in the superficial layer of the brain, and deep brain regions 5, located in the deep layer of the brain. Superficial brain region 1 may include the cerebral cortex. Functional areas such as motor and visual functions are present in the cerebral cortex. Deep brain region 5 may include deep brain nuclei, including important functional areas such as the nucleus accumbens, caudate nucleus, putamen, globus pallidus, red nucleus, dentate nucleus, ventroposterolateral nucleus, ventroposteromedial nucleus, and ventroposterior nucleus. Furthermore, it is understood that multiple blood vessels exist in superficial brain regions 1 and deep brain regions 5 of the human brain. These multiple blood vessels may include the main blood vessel 3, branch blood vessels 4, and a transition region 2 between the main blood vessel 3 and the branch blood vessels 4. Among them, the branch blood vessels 4 extend from the main blood vessel 3 to branches, and the connection between the main blood vessel and the branch blood vessel (see reference) Figure 6A The connection point C) is located near the brain (e.g., deep brain region 5). Each blood vessel has a vascular channel 6 and a vessel wall 7.

[0027] refer to Figure 1Those skilled in the field of brain-computer interfaces will understand that the surgical implantation of electrode 32 via craniotomy described at the beginning of this article is only applicable to implanting electrode 32 into superficial brain region 1, and not to implanting electrode 32 into deep brain region 5. Furthermore, such a surgical approach requires craniotomy and implantation into deep brain regions, which not only causes significant trauma to the patient but also places a heavy workload on the physician.

[0028] Therefore, this disclosure provides an interventional device 100 for implanting an electrode 32 into the brain via blood vessels (e.g., veins in the brain). The device can implant an electrode 32 into the brain of a living organism (e.g., a human or animal) with at most two vascular punctures, such as a jugular vein puncture and an intracranial vein puncture. This significantly reduces trauma to the patient (only two vascular puncture openings) and lowers the workload of the physician. Furthermore, since blood vessels are distributed in almost all regions of the brain, the electrode 32 can be implanted into almost any region of the brain via the corresponding blood vessels. Taking the subthalamic nucleus (STN) in the deep brain region 5 as an example, the interventional device 100 can establish an electrode implantation path starting from the jugular vein, through the sigmoid sinus to the transverse sinus, then through the sinus confluence to the straight sinus, and finally through the Galen vein and the thalamic striatum vein to implant the electrode 32 into the subthalamic nucleus. Moreover, the electrode implanted using the interventional device 100 of this disclosure can have both neuronal signal acquisition and neuronal stimulation functions. Therefore, the interventional device 100 according to this disclosure not only supports the acquisition of neuronal signals and stimulation of neurons in the superficial brain region 1, but also supports the acquisition of neuronal signals and stimulation of neurons in the deep brain region 5. Furthermore, the interventional device 100 according to this disclosure can specifically set or adjust the insertion direction or target puncture area of ​​the puncture needle in the puncture kit by determining or adjusting the positions of the first support point a and the second support point b. This provides a relatively stable puncture track for the electrode guide needle 103 of the interventional device 100, thereby improving the accuracy of electrode 32 implantation.

[0029] The following will be combined with the appendix Figures 2 to 5C This disclosure provides a detailed description of an interventional device 100 for implanting an electrode 32 into the brain via a blood vessel, according to various embodiments thereof. It will be understood that the actual interventional device 100 may contain other components, which are not shown in the accompanying drawings and will not be discussed herein to avoid obscuring the key points of this disclosure. It should also be noted that, herein, when referring to “distal” or “far-side,” it means the end or side furthest from the operator / surgical practitioner (typically a physician), and when referring to “proximal” or “proximal,” it means the end or side closest to the operator / surgical practitioner (typically a physician).

[0030] Figure 2 and Figure 3 An interventional device 100 for implanting an electrode 32 into the brain via a blood vessel, according to one or more exemplary embodiments of the present disclosure, is illustrated schematically. Figure 2 Primarily used to illustrate the arrangement structure of the interventional device 100. Figure 3 It is mainly used to show the electrode 32 that has been implanted in the brain and the occluder 103-8 used to seal the punctured blood vessel wall 7.

[0031] like Figure 2 As shown, the interventional device 100 for implanting an electrode 32 into the brain via a blood vessel according to this disclosure may include a first guide 101, a second guide 102, and an electrode guiding needle 103. The first guide 101 may be configured to be percutaneously inserted into a blood vessel in a living organism (e.g., a human or animal), and has a distal end 101-1 and a proximal end 101-2 opposite to the distal end 101-1. The distal end 101-1 of the first guide 101 is movable distally within a vascular channel 6 of the blood vessel and establishes a first support point a within the vascular channel 6. Similar to the first guide 101, the second guide 102 also has a distal end 102-1 and a proximal end 102-2 opposite to the distal end 102-1, and the electrode guiding needle 103 also has a distal end 103-1 and a proximal end 103-2 opposite to the distal end 103-1. The distal end 102-1 of the second guide 102 is capable of moving distally within the vascular channel 6 of the blood vessel through the first guide 101, and establishing a second support point b within the vascular channel 6, such that the second guide 102 extends arcuately between the first support point a and the second support point b. The distal end of the electrode guide needle 103 is configured to carry the electrode 32, and the distal end of the electrode guide needle 103 is capable of moving distally within the vascular channel 6 through the first guide 101 and piercing the vessel wall 7 of the blood vessel in the target puncture area between the first support point a and the second support point b, thereby implanting the carried electrode 32 into the brain. In some embodiments, the electrode 32 may be a flexible electrode, such as an electrode wire. The electrode 32 should have sufficient length so that the proximal end of the electrode can be connected to an external data interface, thereby enabling the transmission of neuronal signals acquired from the brain to the data interface. It is understood that, although Figure 2 The cross-sectional shape of the main body of the first guide 101, the second guide 102 and the electrode guide pin 103 is illustrated as a circle, but this is merely exemplary and not limiting. The main body of the first guide 101, the second guide 102 and the electrode guide pin 103 may have any suitable cross-sectional shape.

[0032] In some embodiments, such as Figure 1As shown, the blood vessel may include a main vessel 3 and branch vessels 4. The first support point a may be established in the main vessel 3, and the second support point b may be established in the branch vessel 4. Here, the main vessel 3 may be a vessel with a diameter of approximately 3 mm to 6 mm, and the branch vessel 4 may be a vessel with a diameter of less than 2 mm to 3 mm. Thus, the interventional device 100 can establish the first support point a and the second support point b at the natural bifurcation structure of the blood vessel, such that the second guide 102 extends arcuately between the first support point a and the second support point b. Considering that the second guide 102 and the first guide 101 form a nested structure, the arcuate extension of the second guide 102 may cause the distal end 101-1 of the first guide 101 to bend slightly toward the second guide 102, for example, see [reference needed]. Figure 2 and Figure 3 Furthermore, considering that the electrode guide needle 103 and the first guide 101 also form a nested structure, when the extension direction of the first guide 101, especially its distal end 101-1, is determined, the insertion direction of the electrode guide needle 103, or the target puncture area, is also basically determined accordingly. Here, the insertion direction of the electrode guide needle 103, or the target puncture area, is basically located in the angle region h formed by the central axis 101-4 of the first guide 101 and the second guide 102. When the first support point a is located in the main blood vessel 3 and the second support point b is located in the branch blood vessel 4, the target puncture area can be located in the transition region 2 between the main blood vessel 3 and the branch blood vessel 4. Thus, according to the interventional device 100 of this disclosure, the insertion direction of the electrode guide needle, or the target puncture area, can be specifically set or adjusted by determining or adjusting the positions of the first support point a and the second support point b. Based on this, the interventional device 100 of this disclosure can provide a relatively stable puncture track for the electrode guide needle 103, thereby improving the accuracy of electrode 32 implantation.

[0033] In some embodiments, the first guide 101 may be configured as a support catheter, the outer diameter of the distal end 101-1 of which is substantially equal to the inner diameter of the blood vessel at the first support point a, so as to establish the first support point a in the vascular channel 6. In other embodiments, such as Figure 2As shown, the outer diameter of the distal end 101-1 of the support catheter can also be configured to be smaller than the inner diameter of the blood vessel at the first support point a. Furthermore, the support catheter can have a hollow structure to provide a first working channel (not shown) for the second guide 102 and a second working channel (not shown) for the electrode guide needle 103 within the support catheter. That is, the second guide 102 and the electrode guide needle 103 are removably disposed within their respective working channels. Thus, the second guide 102 and the electrode guide needle 103 can be guided independently of each other within the support catheter. In some alternative embodiments, the support catheter can also provide a common third working channel for the second guide 102 and the electrode guide needle 103 within its interior. That is, the second guide 102 and the electrode guide needle 103 are removably disposed within a common working channel. This simplifies the structure of the support catheter. The support catheter can be made of any suitable material, such as biomedical metallic materials, including but not limited to one or more of stainless steel, synthetic fibers, carbon fibers, titanium alloys, gold, silver, etc. To facilitate bending of the distal end 101-1 of the support catheter, the distal end 101-1 of the support catheter may have a lower material hardness than the proximal end 101-2 of the support catheter. In some embodiments, the distal end 101-1 of the support catheter may be configured with a first imaging mark to facilitate the positioning of the first support point a under imaging.

[0034] In some embodiments, the second guide 102 can be supported or tensioned on the vessel wall 7 at the second support point b, thereby tautning the vessel wall 7 at the second support point b. This establishes a fixed or anchored second support point b in the vascular channel 6. On the other hand, tautness of the vessel wall 7 facilitates the electrode guide needle 103's successful puncture of the vessel wall 7 (or, as described below, through the vessel wall 7 using a puncture needle 21). In some embodiments, to establish the second support point b, the second guide 102 can be configured as a support assembly including a guide wire (not shown), a guide tube 102-3, and a support bracket 102-4, wherein the guide wire guides the guide tube 102-3, the guide tube 102-3 guides the support bracket 102-4, and the support bracket 102-4 is used to support the vessel wall 7. Specifically, the stent assembly can establish the second support point b through the following steps: First, the distal end of the guide wire of the stent assembly is delivered to the second support point b through the working channel of the support catheter; then, the distal end of the guide tube 102-3 of the stent assembly is delivered to the second support point b along the guide wire, the guide wire is withdrawn, but the guide tube 102-3 is left in place; then, the support stent 102-4 of the stent assembly is pushed to the second support point b, the guide tube 102-3 is withdrawn, so that the support stent 102-4 opens at the second support point b and is supported on the vessel wall 7.

[0035] The guide wire can have any suitable elongated structure. In some embodiments, the guide wire can have a gradually tapering outer diameter, for example, it can taper from proximal to distal. The guide wire can be made of a metallic material, including but not limited to: stainless steel, aluminum alloy, tungsten, etc. Furthermore, for ease of insertion, the proximal end of the guide wire can have a greater material hardness than the distal end. Additionally, the distal end of the guide wire can also be shaped.

[0036] In some embodiments, in order to deliver the distal end of the guide tube 102-3 to the second support point b along the guide wire, the guide tube 102-3 can be fitted onto the guide wire and is movable along the guide wire. For fitting onto the guide wire, the inner diameter of the guide tube 102-3 can be configured to be greater than or equal to the outer diameter of the guide wire. Furthermore, for ease of insertion, the proximal end of the guide tube 102-3 can have a greater material hardness than the distal end of the guide tube 102-3. The guide tube 102-3 can be made of any suitable material, such as one or more of the following: acrylonitrile butadiene styrene (ABS), polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), polymethyl methacrylate (PMP), polymethyl methacrylate (PMMA); polycarbonate (PC), polyphenylene oxide (PPO), modified phenylene oxide (modified PPO), polyphenylene ether (PPE); polyimide (PI), polybenzimidazole (PBI); polyphenylene sulfide (PPS), polyether ether ketone (PEEK); fluorinated ethylene-propylene (FEP), ethylene-chlorotrifluoroethylene (ECTFE), ethylene, ethylene-tetrafluoroethylene (ETFE), polychlorotrifluoroethylene (PCTFE), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyvinylidene fluoride (PVDF); elastomeric silicone polymers, polyether front-end amides or thermoplastic copolyethers (PEBAX); metals (e.g., stainless steel and nickel-titanium alloys), etc. The distal end of the guide tube 102-3 may be constructed with a second imaging marker to facilitate positioning under the image.

[0037] In some instances, to enable the stent 102-4 to automatically open after the guide tube 102-3 is withdrawn, the stent 102-4 can be constructed as a self-expanding stent. The self-expanding stent may include a proximal first push rod and a distal stent body 102-4-1. The first push rod is used to push the stent body 102-4-1 through the guide tube 102-3. The stent body 102-4-1 is capable of radially opening and being supported on the vessel wall 7 by self-expanding force after exiting the guide tube 102-3. To allow the stent body 102-4-1 to exit the guide tube 102-3, the guide tube 102-3 can be withdrawn, or the stent body 102-4-1 can be pushed distally using the first push rod. To generate self-expanding force, the stent body 102-4-1 of the self-expanding stent may be made of a shape memory alloy material. In some embodiments, such as Figure 2 As shown, the stent body 102-4-1 may include multiple closed-loop network units and multiple open-loop network units. To allow the self-expanding stent to pass smoothly through the guide tube 102-3, the outer diameter of the self-expanding stent in its compressed state can be configured to be smaller than or substantially equal to the inner diameter of the guide tube 102-3. A third imaging mark may be constructed on the stent body 102-4-1 of the self-expanding stent to facilitate the positioning of the second support point b under the image.

[0038] Figures 4A to 4C The electrode guide needle 103 of an interventional device 100 for implanting an electrode 32 into the brain via a blood vessel, according to one or more exemplary embodiments of the present disclosure, is illustrated schematically. It should be noted here that... Figures 4A to 4C The embodiments differ only in the mating parts 103-7; therefore, for ease of understanding and comparison, in Figures 4A to 4C The same reference numerals were used in the figures.

[0039] In some embodiments, such as Figure 2 and Figures 4A to 4C As shown, the electrode guide pin 103 can be removably disposed within the working channel of the support catheter, and may include a proximal second push rod 103-6 and a distal mating portion 103-7 for the electrode 32. To achieve mating between the electrode 32 and the electrode guide pin 103, a hole may be constructed on the electrode 32; the mating portion 103-7 of the electrode guide pin 103 may be constructed as a tip that can pass through the hole in the electrode 32. In some embodiments, such as Figure 4A and Figure 4B As shown, the tip may have a stepped structure, enabling it to carry electrode 32 when moved distally, and electrode 32 to detach from the tip when it is retracted proximally after implantation in the brain. Alternatively, as... Figure 4CAs shown, the tip can also have a tapered structure. The electrode guide pin 103 can be made of any suitable metallic material, such as biomedical metallic materials, including but not limited to stainless steel or tungsten. In some embodiments, such as Figure 2 As shown, the electrode guide needle 103 may be equipped with a puncture catheter 103-5 for guiding the puncture needle 103 to the target puncture area. In some embodiments, the puncture needle 103 may be guided by the puncture catheter 103-5 to a position approximately 0.5 mm, 1 mm, 1.5 mm, or 2 mm from the target puncture area and then stopped moving. Then, the second push rod 103-6 of the puncture needle 103 is rapidly pushed to puncture the blood vessel wall 7. In some embodiments, such as... Figure 2 As shown, the puncture catheter 103-5 can be fitted onto the puncture needle 103 and can puncture the blood vessel wall 7. The puncture catheter 103-5 can be formed of the same material as the first guide 101 configured to support the catheter.

[0040] In some embodiments, Figure 2 Reference numerals 103-5 in the accompanying drawings may refer to puncture needles provided with electrode guide needle 103. The puncture needle has a tip capable of piercing the blood vessel wall and an internal cavity to accommodate the electrode guide needle 103 carrying the electrode. The puncture needle is used to puncture the blood vessel so that the electrode guide needle 103 carrying the electrode can pass directly through the puncture hole, protecting the electrode guide needle 103 and its carried electrode. The puncture needle can be made of any suitable metallic material, such as biomedical metallic materials, including but not limited to one or more of stainless steel, synthetic fibers, carbon fibers, titanium alloys, gold, silver, and tungsten. The puncture needle and electrode guide needle 103 together form a puncture kit. In some embodiments, a needle sheath may also be provided with the puncture needle. The needle sheath is fitted over the puncture needle to protect the tip of the puncture needle from piercing the catheter (e.g., the first guide 101).

[0041] Figures 5A to 5C Several example occluders 103-8 are shown in the puncture kit of an interventional device 100 for implanting an electrode 32 into the brain via a blood vessel, according to one or more exemplary embodiments of this disclosure. It should be noted here that... Figures 5A to 5C The embodiments differ only in the sealing structure 103-8-2; therefore, for ease of understanding and comparison, in Figures 5A to 5C The same reference numerals were used in the figures.

[0042] In some embodiments, the puncture kit may be equipped with an occluder 103-8 for sealing the punctured vessel wall 7. This ensures that blood and emboli do not permeate through the punctured vessel wall 7 into non-vascular areas. In some embodiments, the occluder 103-8 may be configured as a self-expanding occluder, comprising a proximal third push rod 103-8-1 and a distal occlusion structure 103-8-2. The third push rod 103-8-1 is used to push the occlusion structure 103-8-2 through the puncture catheter 103-5. The occlusion structure 103-8-2 is capable of radially opening and adhering to the punctured vessel wall 7 by self-expanding force after exiting the puncture catheter 103-5. To allow the occlusion structure 103-8-2 to exit the puncture catheter 103-5, the puncture catheter 103-5 can be retracted, or the occlusion structure 103-8-2 can be pushed distally by the third push rod 103-8-1. In some embodiments, the occlusion structure 103-8-2 may be located on the inner side (not shown) or outer side (see Figure 7) of the vessel wall 7. Figure 2 The catheter 103-5 is attached to the punctured vessel wall 7. To achieve occlusion on the outside of the vessel wall 7, the catheter can be inserted as follows: Figure 2 The blood vessel wall is punctured as shown 7. To generate self-expansion force, the occlusion structure 103-8-2 of the self-expansion occluder can be made of a shape memory alloy material. In some embodiments, such as Figures 5A to 5C As shown, the sealing structure 103-8-2 of the plugging device 103-8 can have a flower-shaped structure, wherein, Figure 5A The center is shaped like a three-petaled flower. Figure 5B The center is shaped like a four-petaled flower. Figure 5C The central part is shaped like a five-petaled flower. It is understood that these different flower shapes are merely exemplary and not limiting; the occlusion structure 103-8-2 of the occluder 103-8 can also have other suitable shapes, such as umbrella-shaped, disc-shaped, ring-shaped, cylindrical, or funnel-shaped structures. Furthermore, in some embodiments, an electrolytic detachment portion can be constructed at the distal end of the third push rod 103-8-1 to disengage the occlusion structure 103-8-2 from the third push rod 103-8-1 upon energization. Thus, the third push rod 103-8 can be withdrawn outside the blood vessel.

[0043] According to various embodiments of the present disclosure, the interventional device 100 implants an electrode 32 into the brain by establishing an electrode implantation path in a blood vessel, thereby reducing trauma to the patient and decreasing the workload of the physician. Furthermore, since blood vessels are distributed in almost all areas of the brain, the electrode 32 can be implanted into almost any area of ​​the brain through the corresponding blood vessel. In addition, according to the interventional device 100 of the present disclosure, the needle insertion direction or target puncture area of ​​the puncture kit can be specifically set or adjusted by determining or adjusting the positions of the first support point a and the second support point b, thereby providing a relatively stable puncture track for the puncture kit of the interventional device 100 and improving the accuracy of electrode 32 implantation. Furthermore, the interventional device 100 of the present disclosure may be equipped with an occluder 103-8 for sealing the punctured blood vessel wall 7, thereby ensuring that blood and emboli do not seep into non-vascular areas through the punctured blood vessel wall 7.

[0044] Figures 6A to 6G The illustration schematically depicts the use of an interventional device for implanting electrodes into the brain via blood vessels, according to other exemplary embodiments of the present disclosure. Figure 6A As shown, the direction in which the main vessel 3 extends near the junction C with the branch vessel 4 is the first direction D1, and the direction in which the branch vessel 4 extends near the junction C is the second direction D2. Figure 6B As shown, the first guide 101 (also referred to as the "first catheter 101" in this exemplary embodiment) travels within the lumen of the main blood vessel 3, its distal end reaching and floating at a first position P1 within the main blood vessel 3. The first position P1 is located near the connection point C, which may correspond to the first support point a in the above embodiment. "Near" the connection point C means not too far from it, so that the first position P1 is suitable for other components to enter the branch blood vessel 4 from the first position P1 via the connection point C. At this time, due to the mechanical strength of the first catheter 101 itself and the driving force of the blood flow within the lumen of the main blood vessel 3, the opening of the distal end of the first catheter 101 is substantially oriented in the first direction D1. The outer diameter of the distal end of the first catheter 101 is smaller than the inner diameter of the main blood vessel 3, allowing the distal end of the first catheter 101 to float radially within the main blood vessel 3 to change the orientation of the opening of the distal end of the first catheter 101 in subsequent steps.

[0045] like Figure 6CAs shown, the stent 102-4-1 (i.e., the stent body 102-4-1 in the above embodiment) located at its distal end in the stent assembly can reach the distal end of the first catheter 101 along the lumen of the first catheter 101, and enter the branch vessel 4 through the connection point C, and be fixed at the second position P2 located in the branch vessel 4. The second position P2 can also be located near the connection point C, which can correspond to the second support point b in the above embodiment. The operation process of fixing the stent 102-4-1 to the second position P2 can be referred to the following description. Figures 7A to 7D The described operation process. The stent assembly also includes a stent pusher 102-4-2 connected to the stent 102-4-1. After the stent 102-4-1 is fixed at the second position P2, the stent pusher 102-4-2, connected to the rear of the stent 102-4-1, extends between the first position P1 and the second position P2 along the branching direction of the blood vessel, thereby causing the distal opening of the first catheter 101 to deflect in the second direction D2 under the action of the stent pusher 102-4-2. Thus, the distal opening of the first catheter 101 faces a third direction D3, which is located in the angle region between the first direction D1 and the second direction D2 (similar to the angle region h in the above embodiment).

[0046] The third catheter 103-5 is inserted into the first catheter 101, such that the distal end of the third catheter 103-5 reaches and extends beyond the lumen of the first catheter 101, approaching the puncture site P3 on the vessel wall. Then, before the third catheter 103-5 punctures the vessel wall, the electrode guide needle 103 is inserted into the third catheter 103-5, with its distal end approaching the distal end of the third catheter 103-5 along its lumen. After the distal end of the electrode guide needle 103 approaches the distal end of the third catheter 103-5 (either within the lumen of the third catheter 103-5 or slightly beyond its lumen), the distal end of the electrode guide needle 103 is not advanced further to avoid puncturing the vessel wall at this point; and, as Figure 6D As shown, the distal end of the third catheter 103-5 punctures the blood vessel wall at the puncture site P3 and reaches outside the blood vessel but does not enter the brain. The electrode guide needle 103 continues to move along the lumen of the third catheter 103-5 and passes through the distal end of the third catheter 103-5 to enter the brain 5, thereby implanting the carried electrode 32 into the brain 5.

[0047] After electrode 32 is implanted in brain 5, as Figure 6FAs shown, the electrode guide needle 103 is rapidly withdrawn along the lumen of the third catheter 103-5, and the occluder assembly 103-8 is inserted into the third catheter 103-5 so that the occlusion structure 103-8-2 included in the occluder assembly 103-8 for sealing the puncture site on the blood vessel wall reaches the distal end of the third catheter 103-5 along the lumen of the third catheter 103-5, and opens after extending from the distal end of the third catheter 103-5. Figure 6G As shown, the third catheter 103-5 is retracted, and the occluder push rod connected to the occlusion structure 103-8-2 in the occluder assembly 103-8 is retracted so that the occlusion structure 103-8-2 fits against the vessel wall to seal the puncture site.

[0048] Figures 7A to 7F The illustration schematically depicts the use of an interventional device for implanting electrodes into the brain via blood vessels, according to other exemplary embodiments of the present disclosure. In these exemplary embodiments, the interventional device can perform the aforementioned combinations Figure 6A and Figure 6B The described operation. After the distal end of the first catheter 101 reaches the first position P1, the guide wire 102-5 can be inserted into the first catheter 101 and allowed to travel along the lumen of the first catheter 101 to the distal end of the first catheter 101, pass through the connection point C to enter the branch vessel 4, and reach the vicinity of the second position P2. Although in Figure 7A In the example shown, the distal end of the guidewire 102-5 reaches a position in the branch vessel 4 beyond the second position P2 (i.e., further than the second position P2). Those skilled in the art will understand that in other examples, the distal end of the guidewire 102-5 may reach exactly at the second position P2, or reach a position in the branch vessel 4 slightly closer to the second position P2. The guidewire 102-5 is thin and its distal end has good shaping ability, making it easy for it to enter the branch vessel 4 from the main vessel 3 via the junction C.

[0049] After that, as Figure 7B As shown, the second catheter 102-3 is fitted over the guide wire 102-5 and inserted into the first catheter 101, such that the distal end of the second catheter 102-3 can reach at least the second position P2 along the extension trajectory of the guide wire 102-5, that is, reach the second position P2 or a position in the branch vessel 4 that is further than the second position P2. Those skilled in the art will understand that in other embodiments, the distal end of the second catheter 102-3, guided by the guide wire 102-5, can travel slightly further than the distal end of the guide wire 102-5.

[0050] like Figure 7CAs shown, after the distal end of the second catheter 102-3 reaches at least the second position P2, the guide wire 102-5 is retracted along the lumen of the second catheter 102-3 so that the stent assembly can enter the second catheter 102-3. This allows the stent assembly to enter the second catheter 102-3 and the stent 102-4-1 to reach the second position P2 along the lumen of the second catheter 102-3. After the stent 102-4-1 reaches the second position P2, the second catheter 102-3 is retracted along the trajectory of the stent push rod 102-4-2 so that the stent 102-4-1 is exposed outside the second catheter 102-3, thereby allowing the stent 102-4-1 to self-expand and be fixed at the second position P2; and the second catheter 102-3 is retracted so that the distal end of the second catheter 102-3 reaches and is at a first specific position P4-1, as... Figure 7D As shown. The first specific position P4-1 corresponds to the first puncture position P3-1. The electrode guide needle 103 is inserted into the second catheter 102-3, and the distal end of the electrode guide needle 103 is advanced along the lumen of the second catheter 102-3 to reach the distal end of the second catheter 102-3. After passing the distal end of the second catheter 102-3, it continues to advance to puncture the blood vessel wall at the first puncture position P3-1 corresponding to the first specific position P4-1, thereby entering the brain 5 to implant the carried electrode into the brain 5. Those skilled in the art will understand that a third catheter 103-5 can also be inserted into the second catheter 102-3 and puncture the blood vessel wall at the first puncture position P3-1. Then, the electrode guide needle 103 is inserted from the third catheter 103-5 so that the electrode guide needle 103 finally reaches the brain 5.

[0051] like Figure 7E As shown, the second catheter 102-3 is withdrawn again, so that its distal end reaches and is at the second specific position P4-2, which corresponds to the second puncture position P3-2. The electrode guide needle 103 (or the third catheter 103-5) is inserted into the second catheter 102-3, and its distal end travels along the lumen of the second catheter 102-3, puncturing the vessel wall at the second puncture position P3-2. Figure 7F As shown, the second catheter 102-3 is withdrawn again, so that the distal end of the second catheter 102-3 reaches and is located at the third specific position P4-3, which corresponds to the third puncture position P3-3. The electrode guide needle 103 (or the third catheter 103-5) is inserted into the second catheter 102-3, and the distal end of the electrode guide needle 103 is advanced along the lumen of the second catheter 102-3, and punctures the blood vessel wall at the third puncture position P3-3.

[0052] In the presence of the third conduit 103-5, the occluder assembly is used in the same manner as in the above embodiments. In the absence of the third conduit 103-5, for example... Figures 7D to 7F As shown, after the electrode guide needle 103 has been punctured and before its distal end is withdrawn into the blood vessel, the occluder assembly is inserted into the second catheter 102-3, allowing the occlusion structure to travel along the lumen of the second catheter 102-3 to its distal end and continue beyond that point to reach the vicinity of the puncture site (one of P3-1 to P3-3). After the distal end of the electrode guide needle 103 is withdrawn into the blood vessel, the occlusion structure is rapidly propelled through the puncture site through the vessel wall and, upon reaching the outside of the vessel, opens and adheres to the vessel wall to seal the puncture site. Compared to Figure 6F The sealing method shown allows for a shorter exposure time of the puncture hole (the time between the withdrawal of the electrode guide needle 103 from the puncture hole and the sealing structure sealing the puncture hole).

[0053] In some embodiments, Figures 7A to 7F The electrode guide pin 103 in the depicted embodiment can be implemented as follows: Figure 8A and Figure 8B The puncture kit shown includes a puncture needle 21, a needle sheath 22, and an electrode guide needle 23 for carrying the electrode 24. Figures 6A to 6G The electrode guide pin 103 in the depicted embodiment can be implemented as follows: Figure 8A and Figure 8B The electrode guide needle 23 and the third catheter 103-5 in the puncture kit shown can be implemented as follows: Figure 8A and Figure 8B The puncture kit shown includes a puncture needle 21. The distal end of the puncture needle 21 has a tip for piercing the blood vessel wall and an internal cavity. The puncture needle 21 can be made of any suitable metallic material, such as biomedical metallic materials, including but not limited to one or more of stainless steel, synthetic fibers, carbon fibers, titanium alloys, gold, and silver. A needle sheath 22 is fitted over the puncture needle 21 to protect the tip of the puncture needle 21 from piercing the catheter outside the puncture needle 21. The needle sheath 22 can be made of a material softer than metal, such as the same material as the catheter. Alternatively, the needle sheath 22 can be made of metal but constructed without a tip to avoid piercing the catheter. An electrode guide needle 23 is located within the cavity of the puncture needle, and its distal end has a mating portion configured to carry an electrode. The electrode 24 carried by the electrode guide needle 23 can be carried inside the puncture needle 21 (e.g., Figure 8A (As shown), it can also be carried outside the puncture needle 21 and the needle sheath 22 (as shown). Figure 8B (As shown).

[0054] The following is combined Figures 7A to 7FThe described embodiment illustrates the operation of the puncture kit. The puncture kit is inserted into the second catheter 102-3, such that the distal end of the puncture needle 21, the distal end of the needle sheath 22, and the distal end of the electrode guide needle 23 within the puncture kit travel together along the lumen of the second catheter 102-3 to reach its distal end. After passing (or extending) the distal end of the second catheter 102-3, the distal end of the needle sheath 22 stops traveling, while the distal ends of the puncture needle 21 and the distal end of the electrode guide needle 23 continue to travel together to extend from the needle sheath 22 and approach the puncture site. Upon reaching the puncture site, the distal end of the puncture needle 21 pierces the vessel wall at the puncture site and reaches outside the vessel. The distal end of the puncture needle 21 stops traveling after reaching the outside of the blood vessel, while the distal end of the electrode guide needle 23 continues to travel within the cavity of the puncture needle 21 and passes through the distal end of the puncture needle 21 to enter the brain, thereby implanting the carried electrode into the brain.

[0055] In the foregoing description of the embodiments of this disclosure, the operation of the interventional device 100 is described using a scenario near the junction of the main blood vessel 3 and the branch blood vessels 4 extending from the main blood vessel 3. In fact, the interventional device 100 according to any of the above embodiments of this disclosure can also operate in scenarios other than the junction of the main blood vessel 3 and the branch blood vessel 4. For example, in other embodiments, the operation scenario of the interventional device 100 may be near the junction of a first blood vessel segment and a second blood vessel segment, the first blood vessel segment extending along a first direction and the second blood vessel segment extending along a second direction different from the first direction. For example, the first blood vessel segment and the second blood vessel segment may be connected to form part of a single, unbranched blood vessel with an arcuate curvature.

[0056] In another aspect, this disclosure also provides a medical device, which may include the interventional device 100 described in any of the above embodiments of this disclosure, which will not be repeated here.

[0057] The terms “left,” “right,” “front,” “back,” “top,” “bottom,” “upper,” “lower,” “high,” “lower,” etc., used in the specification and claims, if present, are for descriptive purposes and not necessarily for describing constant relative positions. It should be understood that such terms are interchangeable where appropriate, so that embodiments of this disclosure described herein can, for example, operate in orientations different from those shown or otherwise described herein. For example, when the device in the drawings is reversed, a feature previously described as “above” other features may now be described as “below” other features. The device may also be oriented in other ways (rotated 90 degrees or in other orientations), in which case the relative spatial relationships will be interpreted accordingly.

[0058] In the specification and claims, when an element is described as being "on top of," "attached" to, "connected" to, "coupled" to, "coupled to," or "in contact with" another element, the element may be directly located on top of, directly attached to, directly connected to, directly coupled to, directly coupled to, or directly in contact with the other element, or one or more intermediate elements may be present. Conversely, when an element is described as being "directly" located on top of, directly attached to, directly connected to, directly coupled to, directly coupled to, or directly in contact with another element, no intermediate elements are present. In the specification and claims, when a feature is arranged "adjacent" to another feature, it may mean that a feature has a portion overlapping with the adjacent feature or a portion located above or below the adjacent feature.

[0059] As used herein, the term "exemplary" means "serving as an example, instance, or illustration," and not as a "model" to be precisely copied. Any implementation described herein by example is not necessarily to be construed as preferred or advantageous over other implementations. Furthermore, this disclosure is not limited to any theory expressed or implied as given in the art, background, summary of the invention, or detailed description.

[0060] As used herein, the term "substantially" means any minor variation resulting from design or manufacturing defects, device or component tolerances, environmental influences, and / or other factors. The term "substantially" also allows for differences from the perfect or ideal situation due to parasitic effects, noise, and other practical considerations that may exist in the actual implementation.

[0061] Additionally, terms such as “first,” “second,” etc., may be used in this document for reference purposes only and are not intended to be limiting. For example, unless the context clearly indicates otherwise, the words “first,” “second,” and other such numerical terms relating to structures or elements do not imply order or sequence.

[0062] It should also be understood that when the term “including / contains” is used herein, it indicates the presence of the indicated feature, whole, step, operation, unit and / or component, but does not preclude the presence or addition of one or more other features, wholes, steps, operations, units and / or components and / or combinations thereof.

[0063] In this disclosure, the term “provide” is used broadly to cover all ways of obtaining an object, and therefore “provide an object” includes, but is not limited to, “purchasing,” “preparing / manufacturing,” “arranging / setting up,” “installing / assembling,” and / or “ordering” an object.

[0064] As used herein, the term “and / or” includes any and all combinations of one or more of the listed items in association. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of this disclosure. As used herein, the singular forms “a,” “an,” and “the” are also intended to include the plural forms unless the context clearly indicates otherwise.

[0065] Those skilled in the art will recognize that the boundaries between the above operations are merely illustrative. Multiple operations may be combined into a single operation, a single operation may be distributed among additional operations, and operations may be performed with at least partial overlap in time. Moreover, alternative embodiments may include multiple instances of a particular operation, and the order of operations may be changed in various other embodiments. However, other modifications, variations, and substitutions are equally possible. Aspects and elements of all the embodiments disclosed above may be combined in any way and / or in combination with aspects or elements of other embodiments to provide multiple additional embodiments. Therefore, this specification and the accompanying drawings should be considered illustrative rather than restrictive.

[0066] While specific embodiments of this disclosure have been described in detail by way of example, those skilled in the art should understand that the examples are for illustrative purposes only and not intended to limit the scope of this disclosure. The various embodiments disclosed herein can be combined in any way without departing from the spirit and scope of this disclosure. Those skilled in the art should also understand that various modifications can be made to the embodiments without departing from the scope and spirit of this disclosure. The scope of this disclosure is defined by the appended claims.

Claims

1. An interventional device for implanting an electrode into the brain via a blood vessel, said blood vessel having a vascular channel and a vascular wall, and said blood vessel including a first vascular segment and a second vascular segment extending in different directions, the interventional device comprising: A first guide, the distal end of which is movable distally within the vascular channel and establishes a first support point within the vascular channel, the first support point being located in the first vascular segment; The second guide, the distal end of which can pass through the first guide and move distally within the vascular channel to establish a second support point in the vascular channel, such that the second guide extends between the first support point and the second support point, the second support point being located in the second vascular segment; as well as A puncture kit, the puncture kit being used to carry an electrode, wherein the distal end of the puncture kit is capable of moving distally within a vascular channel through the first guide and puncturing the vessel wall in a target puncture area between the first support point and the second support point, thereby implanting the carried electrode into the brain. The second guide and the puncture kit can be guided independently of each other within the first guide.

2. The interventional device according to claim 1, wherein, The first guide has a first working channel for the second guide and a second working channel for the puncture kit.

3. The interventional device according to claim 1, wherein, The first guide has a common third working channel for the second guide and the puncture kit.

4. The interventional device according to claim 1, wherein, The first guide is constructed as a support catheter, the outer diameter of the distal side of the support catheter being substantially equal to the inner diameter of the blood vessel at the first support point, so as to establish the first support point in the vascular channel.

5. The interventional device according to claim 1, wherein, The distal end of the first guide has a lower material hardness than the proximal end of the first guide.

6. The interventional device according to claim 1, wherein, The distal end of the first guide has a development mark.

7. The interventional device according to claim 1, wherein, The distal end of the second guide has a developing mark.

8. The interventional device according to claim 1, wherein, The proximal end of the second guide has a greater material hardness than the distal end of the second guide.

9. The interventional device according to claim 1, wherein, The second guide is constructed as a stent assembly, which includes a guide wire, a guide tube, and a support stent. The guide wire guides the guide tube, the guide tube guides the support stent, and the support stent supports the blood vessel wall.

10. The interventional device according to claim 9, wherein, The distal end of the guidewire can be shaped.

11. The interventional device according to claim 9, wherein, The guidewire gradually tapers from the proximal end to the distal end.

12. The interventional device according to claim 9, wherein, The guide tube is fitted onto the guide wire and can move along the guide wire.

13. The interventional device according to claim 9, wherein, The inner diameter of the guide tube is configured to be greater than or equal to the outer diameter of the guide wire.

14. The interventional device according to claim 9, wherein, The guide wire is made of metal.

15. The interventional device according to claim 9, wherein, The guide tube is made of one or more of the following materials: acrylonitrile butadiene styrene (ABS), polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), polymethyl methacrylate (PMP), polymethyl methacrylate (PMMA); polycarbonate (PC), polyphenylene oxide (PPO), modified phenylene oxide (modified PPO), polyphenylene ether (PPE); polyimide (PI), polybenzimidazole (PBI); polyphenylene sulfide (PPS), polyether ether ketone (PEEK); fluorinated ethylene-propylene (FEP), ethylene-chlorotrifluoroethylene (ECTFE), ethylene, ethylene-tetrafluoroethylene (ETFE), polychlorotrifluoroethylene (PCTFE), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyvinylidene fluoride (PVDF); elastomeric silicone polymers, polyether front-stage amides or thermoplastic copolyethers (PEBAX); metals.

16. The interventional device according to claim 9, wherein, The support stent is constructed as a self-expanding stent, which includes a proximal first push rod and a distal stent body. The first push rod is used to push the stent body through the guide tube. The stent body can radially open and be supported on the blood vessel wall by self-expanding force after leaving the guide tube.

17. The interventional device according to claim 16, wherein, The self-expanding stent can be separated from the guide tube by retracting the guide tube or by pushing the stent body distally with the first push rod.

18. The interventional device according to claim 16, wherein, The distal end of the guiding tube is provided with a radiopaque marker, and a radiopaque marker is also provided on the stent body of the self-expanding stent.

19. The interventional device according to claim 16, wherein, The self-expanding support body includes multiple closed-loop network units and multiple open-loop network units.

20. The interventional device according to claim 16, wherein, The outer diameter of the self-expanding stent under compression is less than or equal to the inner diameter of the guide tube.

21. The interventional device according to claim 1, wherein, The puncture kit includes: a puncture needle with a distal tip for puncture and an internal cavity; a needle sheath fitted over the puncture needle to protect the tip of the puncture needle; and an electrode guide needle located within the cavity of the puncture needle, wherein the distal end of the electrode guide needle has a mating portion for carrying an electrode.

22. The interventional device according to claim 21, characterized in that, The mating part of the electrode guide pin is constructed as a tip, which can pass through a hole constructed in the electrode for mating with the electrode guide pin.

23. The interventional device according to claim 22, characterized in that, The tip has a stepped or conical structure, which allows it to carry an electrode when it moves distally, and the electrode to detach from the tip when it is withdrawn proximally after implantation in the brain.

24. The interventional device according to claim 1, wherein, The puncture kit is equipped with a puncture catheter for guiding the puncture kit to the target puncture area.

25. The interventional device according to claim 24, characterized in that, The puncture kit is equipped with a occluder for sealing the punctured blood vessel wall.

26. The interventional device according to claim 25, characterized in that, The occluder is constructed as a self-expanding occluder, which includes a proximal third push rod and a distal occlusion structure. The third push rod is used to push the occlusion structure through the puncture catheter. The occlusion structure can radially open and adhere to the punctured blood vessel wall by self-expanding force after leaving the puncture catheter.

27. The interventional device according to claim 26, characterized in that, The sealing structure of the occluder can be flower-shaped, umbrella-shaped, disc-shaped, ring-shaped, cylindrical, or funnel-shaped.

28. The interventional device according to claim 26, characterized in that, An electrolytic release part is provided at the distal end of the third push rod to allow the sealing structure to detach from the third push rod when energized.

29. The interventional device according to claim 1, wherein, The first vascular segment is the main vessel, and the second vascular segment consists of branch vessels extending from the main vessel.

30. An interventional device for implanting an electrode into the brain via a blood vessel, said blood vessel having a vascular channel and a vascular wall, and said blood vessel including a first vascular segment and a second vascular segment extending in different directions, the interventional device comprising: A first guide, the distal end of which is movable distally within the vascular channel and establishes a first support point within the vascular channel, the first support point being located in the first vascular segment; The second guide, the distal end of which can pass through the first guide and move distally within the vascular channel to establish a second support point in the vascular channel, such that the second guide extends between the first support point and the second support point, the second support point being located in the second vascular segment; as well as A puncture kit for carrying an electrode, wherein the distal end of the puncture kit is capable of moving distally within a vascular channel through the first guide and puncturing the vascular wall in a target puncture region between the first support point and the second support point, thereby implanting the carried electrode into the brain, the target puncture region being located in the angle region formed by the central axis of the first guide and the second guide, and the direction of puncturing the vascular wall being adjusted based on the positions of the first support point and the second support point.

31. The interventional device according to claim 30, wherein, The first guide has a first working channel for the second guide and a second working channel for the puncture kit.

32. The interventional device according to claim 30, wherein, The first guide has a common third working channel for the second guide and the puncture kit.

33. The interventional device according to claim 30, wherein, The first guide is constructed as a support catheter, the outer diameter of the distal side of the support catheter being substantially equal to the inner diameter of the blood vessel at the first support point, so as to establish the first support point in the vascular channel.

34. The interventional device according to claim 30, wherein, The distal end of the first guide has a lower material hardness than the proximal end of the first guide.

35. The interventional device according to claim 30, wherein, The distal end of the first guide has a development mark.

36. The interventional device according to claim 30, wherein, The distal end of the second guide has a developing mark.

37. The interventional device according to claim 30, wherein, The proximal end of the second guide has a greater material hardness than the distal end of the second guide.

38. The interventional device according to claim 30, wherein, The second guide is constructed as a stent assembly, which includes a guide wire, a guide tube, and a support stent. The guide wire guides the guide tube, the guide tube guides the support stent, and the support stent supports the blood vessel wall.

39. The interventional device according to claim 38, wherein, The distal end of the guidewire can be shaped.

40. The interventional device according to claim 38, wherein, The guidewire gradually tapers from the proximal end to the distal end.

41. The interventional device according to claim 38, wherein, The guide tube is fitted onto the guide wire and can move along the guide wire.

42. The interventional device according to claim 38, wherein, The inner diameter of the guide tube is configured to be greater than or equal to the outer diameter of the guide wire.

43. The interventional device according to claim 38, wherein, The guide wire is made of metal.

44. The interventional device according to claim 38, wherein, The guide tube is made of one or more of the following materials: acrylonitrile butadiene styrene (ABS), polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), polymethyl methacrylate (PMP), polymethyl methacrylate (PMMA); polycarbonate (PC), polyphenylene oxide (PPO), modified phenylene oxide (modified PPO), polyphenylene ether (PPE); polyimide (PI), polybenzimidazole (PBI); polyphenylene sulfide (PPS), polyether ether ketone (PEEK); fluorinated ethylene-propylene (FEP), ethylene-chlorotrifluoroethylene (ECTFE), ethylene, ethylene-tetrafluoroethylene (ETFE), polychlorotrifluoroethylene (PCTFE), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyvinylidene fluoride (PVDF); elastomeric silicone polymers, polyether front-stage amides or thermoplastic copolyethers (PEBAX); metals.

45. The interventional device according to claim 38, wherein, The support stent is constructed as a self-expanding stent, which includes a proximal first push rod and a distal stent body. The first push rod is used to push the stent body through the guide tube. The stent body can radially open and be supported on the blood vessel wall by self-expanding force after leaving the guide tube.

46. ​​The interventional device according to claim 45, wherein, The self-expanding stent can be separated from the guide tube by retracting the guide tube or by pushing the stent body distally with the first push rod.

47. The interventional device according to claim 45, wherein, The distal end of the guiding tube is provided with a radiopaque marker, and a radiopaque marker is also provided on the stent body of the self-expanding stent.

48. The interventional device according to claim 45, wherein, The self-expanding support body includes multiple closed-loop network units and multiple open-loop network units.

49. The interventional device according to claim 45, wherein, The outer diameter of the self-expanding stent under compression is less than or equal to the inner diameter of the guide tube.

50. The interventional device according to claim 30, wherein, The puncture kit includes: a puncture needle with a distal tip for puncture and an internal cavity; a needle sheath fitted over the puncture needle to protect the tip of the puncture needle; and an electrode guide needle located within the cavity of the puncture needle, wherein the distal end of the electrode guide needle has a mating portion for carrying an electrode.

51. The interventional device according to claim 50, characterized in that, The mating part of the electrode guide pin is constructed as a tip, which can pass through a hole constructed in the electrode for mating with the electrode guide pin.

52. The interventional device according to claim 51, characterized in that, The tip has a stepped or conical structure, which allows it to carry an electrode when it moves distally, and the electrode to detach from the tip when it is withdrawn proximally after implantation in the brain.

53. The interventional device according to claim 30, wherein, The puncture kit is equipped with a puncture catheter for guiding the puncture kit to the target puncture area.

54. The interventional device according to claim 53, characterized in that, The puncture kit is equipped with a occluder for sealing the punctured blood vessel wall.

55. The interventional device according to claim 54, characterized in that, The occluder is constructed as a self-expanding occluder, which includes a proximal third push rod and a distal occlusion structure. The third push rod is used to push the occlusion structure through the puncture catheter. The occlusion structure can radially open and adhere to the punctured blood vessel wall by self-expanding force after leaving the puncture catheter.

56. The interventional device according to claim 55, characterized in that, The sealing structure of the occluder can be flower-shaped, umbrella-shaped, disc-shaped, ring-shaped, cylindrical, or funnel-shaped.

57. The interventional device according to claim 55, characterized in that, An electrolytic release part is provided at the distal end of the third push rod to allow the sealing structure to detach from the third push rod when energized.

58. The interventional device according to claim 30, wherein, The first vascular segment is the main vessel, and the second vascular segment consists of branch vessels extending from the main vessel.

59. An interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a vascular channel and a vascular wall, the blood vessel including a first vascular segment and a second vascular segment extending in different directions, the interventional device comprising: A first guide, the distal end of which is capable of moving distally within the vascular channel to a first position in the first vascular segment; A second guide, the distal end of which is capable of passing through the first guide and moving distally within the vascular channel to a second position in the second vascular segment, and the distal end of the second guide is also capable of retracting from the second position to a third position between the first and second positions; and A puncture kit for carrying an electrode, wherein the distal end of the puncture kit is capable of moving distally within a vascular channel through the first guide to puncture the vascular wall at a puncture site corresponding to the third position, thereby implanting the carried electrode into the brain.

60. The interventional device according to claim 59, wherein, The third position is one or more, such that the distal end of the puncture kit can puncture the blood vessel wall and enter the brain at one or more puncture sites corresponding to one or more of the third positions, thereby implanting one or more electrodes into the brain.

61. The interventional device according to claim 59, wherein: The first guide includes a first conduit, the first conduit being configured such that its distal end can reach and be in the first position. The second guide includes a second catheter and a stent assembly. The second catheter is configured such that its distal end can reach the distal end of the first catheter along the lumen of the first catheter, enter the second vascular segment via the junction of the first and second vascular segments, and reach the second position. The distal end of the second catheter is also configured to retract from the second position to a third position between the first and second positions. The stent assembly includes a stent located at its distal end and a stent pusher connected to the stent. The stent assembly is configured such that the stent can reach the distal end of the second catheter along the lumen of the second catheter after reaching the second position, and is secured at the second position after passing the distal end of the second catheter, such that the stent pusher extends between the first and second positions. The puncture kit is configured such that its distal end can reach the distal end of the second catheter after being withdrawn from the second position to the third position, and continue to travel along the lumen of the second catheter after passing the distal end of the second catheter, so as to puncture the blood vessel wall at the puncture position corresponding to the third position and enter the brain, thereby implanting the carried electrode into the brain.

62. The interventional device according to claim 61, wherein, The second guide also includes: A guidewire is configured such that its distal end can travel along the lumen of the first catheter to the distal end of the first catheter before the stent is secured in the second position, and pass through the connection point to enter the second vascular segment, reaching the vicinity of the second position, wherein... The second catheter is also configured to be able to be fitted over the guidewire before the stent is fixed in the second position, and the distal end of the second catheter can reach at least the second position along the extension path of the guidewire. The guidewire is also configured to be retracted along the lumen of the second catheter after the distal end of the second catheter has reached at least the second position, so that the stent assembly can enter the second catheter. The stent assembly is also configured to access the second catheter and allow the stent to reach the second position along the lumen of the second catheter. The second catheter is also configured to retract after the stent reaches the second position so that the stent self-expands to secure itself in the second position, and to allow the distal end of the second catheter to reach and be in the third position.

63. The interventional device according to claim 61 or 62, further comprising: Occluder assembly, comprising a distal occlusion structure for sealing a puncture site in the vessel wall and an occluder pusher connected to the occlusion structure, the occluder assembly being configured as follows: The occlusion structure can travel along the lumen of the second catheter to its distal end and continue beyond the distal end to reach the vicinity of the puncture site. After at least a portion of the puncture kit is retracted into the blood vessel, the occlusion structure can penetrate the vessel wall through the puncture hole at the puncture site, and open and adhere to the vessel wall after reaching outside the blood vessel to seal the puncture hole.

64. The interventional device according to claim 61 or 62, wherein, The puncture kit includes: a puncture needle with a distal tip for puncturing the blood vessel wall and an internal cavity; a needle sheath fitted over the puncture needle to protect the tip of the puncture needle from puncturing the second catheter; and an electrode guide needle located within the cavity of the puncture needle, the distal end of which has a mating portion configured to carry an electrode.

65. The interventional device according to claim 64, wherein, The puncture kit is configured as follows: The distal end of the puncture needle, the distal end of the needle sheath, and the distal end of the electrode guide needle can reach the distal end of the second catheter along the lumen of the second catheter. After passing the distal end of the second catheter, the distal end of the needle sheath can stop traveling, while the distal ends of the puncture needle and the distal ends of the electrode guide needle can continue to travel to extend out of the needle sheath and approach the puncture site. The distal end of the puncture needle can pierce the blood vessel wall at the puncture site and reach outside the blood vessel but not into the brain; The distal end of the puncture needle can stop traveling after reaching the outside of the blood vessel, while the distal end of the electrode guide needle can continue to travel within the cavity of the puncture needle and pass through the distal end of the puncture needle to enter the brain, thereby implanting the carried electrode into the brain.

66. The interventional device according to claim 65, further comprising: Occluder assembly, comprising a distal occlusion structure for sealing a puncture site in the vessel wall and an occluder pusher connected to the occlusion structure, wherein, The electrode guide needle is also configured to retract along the cavity of the puncture needle after the carried electrodes have been implanted into the brain, so that the occluder assembly can enter the cavity of the puncture needle. The occluder assembly is also configured such that the occlusion structure can reach the distal end of the puncture needle along the cavity of the puncture needle, and after extending from the distal end of the puncture needle, it opens and fits against the vessel wall to seal the puncture site.

67. The interventional device according to claim 59, wherein, The first vascular segment is the main vessel, and the second vascular segment consists of branch vessels extending from the main vessel.

68. A medical device comprising an interventional device for implanting electrodes into the brain via a blood vessel, according to any one of claims 1 to 67.

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