Skin care composition with synergistic anti-allergy effect and skin care product containing skin care composition

Abstract

The invention provides a skin care composition with a synergistic anti-allergy effect and a skin care product containing the skin care composition. The skin care composition with the synergistic anti-allergy effect is prepared from the following components in parts by weight: 10 to 25 parts of plant extract, 10 to 15 parts of humectant and 50 to 90 parts of water, wherein the plant extract is selected from a mixture of a radix gentianae extract, a stephania tetrandra extract, a piper nigrum root extract and a radix sophorae flavescentis extract, and the mass ratio of the radix gentianae extract to the stephania tetrandra extract to the piper nigrum root extract to the radix sophorae flavescentis extract is (5-10): (5-10): (5-10): (1-5). In the implementation process, different plant extracts are mixed for use, and the mass ratio of the plant extracts is controlled, so that the effects of resisting allergy, diminishing inflammation, repairing and moisturizing are achieved; the plant extract has the effects of bacteriostasis and repair, and can fundamentally solve the problem of skin allergy.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a skin care composition with synergistic anti-allergic effects and skin care products containing the same. Background Technology

[0002] Sensitive skin is mainly characterized by subjective symptoms such as burning, stinging, itching, and tightness when stimulated by physical, chemical, or psychological factors, with or without objective signs such as erythema, scaling, and telangiectasia. Currently, most anti-sensitivity skincare products on the market soothe irritation by adding a single anti-sensitivity ingredient (such as bisabolol or dipotassium glycyrrhizate), but these often have limited efficacy and insufficient long-lasting effects. Furthermore, to preserve and stabilize the formula, multiple chemical preservatives and emulsifiers are frequently added, which themselves may become new allergens, leading to a vicious cycle of skin sensitivity problems.

[0003] Plant extracts are widely used in anti-allergy skincare products due to their natural, safe, and multi-functional properties. For example, extracts of gentian root and chamomile are known to have soothing effects. However, the components of different plant extracts are complex, and simple combination may produce antagonistic effects or fail to achieve synergistic enhancement of efficacy. Their compatibility, stability, and synergistic effects still require in-depth research and optimization.

[0004] For example, Chinese patent CN103976907A discloses a plant-based active ingredient composition with soothing and anti-allergic effects. It mainly consists of natural plant active ingredients glycyrrhetinic acid, apigenin, epigallocatechin gallate, baicalin, asiaticoside, and *Fucus vesiculosus* extract. Specifically, it contains 0.1-5% by weight of glycyrrhetinic acid, 0.05-1% by weight of apigenin, 0.05-1% by weight of epigallocatechin gallate, 0.1-3% by weight of asiaticoside, 0.1-5% by weight of baicalin, and 0.1-10% by weight of *Fucus vesiculosus* extract. This composition is used to prepare cosmetics and personal care products with multiple functions including anti-allergy, anti-inflammatory, antipruritic, antioxidant, and moisturizing effects. The composition is safe, non-toxic, and can be compounded with various ingredients to effectively improve sensitive and dry skin and strengthen the skin barrier function.

[0005] However, existing anti-allergy compositions do not have good soothing and moisturizing effects, so there is a need to develop a composition and its preparation method that integrate moisturizing, anti-allergy and repair. Summary of the Invention

[0006] Based on the shortcomings of the existing technology, the purpose of this invention is to provide a skin care composition with synergistic anti-allergic effects and skin care products containing it. By selecting plant extracts and controlling their content, this invention enables the obtained composition to not only have a better anti-allergic effect, but also significantly increase its moisturizing and repairing effects.

[0007] To achieve the above objectives, the present invention employs the following technical solution.

[0008] A skincare composition with synergistic anti-allergic effects comprises the following components by weight: 10-25 parts of plant extract, 10-15 parts of moisturizer, and 50-90 parts of water.

[0009] Preferably, the skin care composition with synergistic anti-allergic effects comprises the following components by weight: 15-22 parts of plant extract, 10-12 parts of moisturizer, and 60-80 parts of water.

[0010] Preferably, the plant extract is selected from one or more of the following: gentian root extract, fangchi extract, kava root extract, sophora root extract, polygonum cuspidatum root extract, chamomile extract, calendula extract, and centella asiatica extract. Preferably, the plant extract is selected from one or more of the following: gentian root extract, stephania tetrandra extract, kava root extract, sophora flavescens root extract, polygonum cuspidatum root extract, chamomile extract, and calendula extract. More preferably, the plant extract is selected from a mixture of gentian root extract, tetrapanax root extract, kava root extract and sophora root extract; More preferably, the mass ratio of the gentian root extract, the stephania tetrandra extract, the kava root extract, and the sophora flavescens root extract is 5-10:5-10:5-10:1-5; Preferably, the mass ratio of the gentian root extract, the stephania tetrandra extract, the kava root extract, and the sophora flavescens root extract is 6-8:6-8:6-8:2-4; Preferably, the mass ratio of the gentian root extract, the stephania tetrandra extract, the kava root extract, and the sophora flavescens root extract is 4:4:4:1.

[0011] Preferably, the humectant is a mixture of 1,2-hexanediol and 1,3-butanediol, with a mass ratio of 1:50-80; preferably 1:50.

[0012] As a preferred embodiment, the skin care composition with synergistic anti-allergic effects comprises the following components by weight: 4 parts gentian root extract, 4 parts Stephania tetrandra extract, 4 parts kava root extract, 1 part Sophora flavescens root extract, 0.2 parts 1,2-hexanediol, 10 parts 1,3-butanediol, and 76.8 parts water.

[0013] The method for preparing the skincare composition with synergistic anti-allergic effects includes the following steps: 1) Mix water, 1,2-hexanediol and 1,3-butanediol to obtain a mixture; 2) Add gentian root extract, fangchi extract, kava root extract and sophora root extract to the mixture obtained in step 1), keep the temperature at 25℃-30℃ and stir evenly until the solution is clear and transparent to obtain the skin care composition with synergistic anti-allergic effect.

[0014] The present invention also provides the application of the above-mentioned skin care composition with synergistic anti-allergic effects in the preparation of skin care products.

[0015] In the implementation of this invention, sodium lecithin and plant extracts are used in combination to achieve anti-allergic, anti-inflammatory, repairing, and moisturizing effects.

[0016] Gentian root extract: can reduce skin redness and sensitivity, and soothe skin discomfort caused by environmental stress or cosmetic allergies; it can inhibit the growth of various bacteria, help prevent skin infections and inflammation, and reduce itching caused by irritation; it can enhance the skin barrier function, maintain skin moisture balance, improve skin's moisturizing ability, and make the skin softer and more supple; it also has whitening and spot-fading functions, and can inhibit enzyme activity, thereby disrupting melanin growth and achieving the goal of delaying aging; it can also scavenge free radicals, restore the skin barrier function, and improve the skin's resistance.

[0017] Stephania tetrandra extract: It can inhibit the inflammatory response of the skin and has the ability to shrink and tighten skin pores.

[0018] Kava pepper root extract: can soothe the skin and reduce skin tension; can promote skin circulation, accelerate metabolism, and make the skin smoother and more delicate; the active ingredients it contains can reduce the stimulation received by skin neurons, relieve skin allergic reactions and stinging and itching, and improve skin allergies instantly.

[0019] Sophora flavescens root extract: It has inhibitory effects on various bacteria, fungi and viruses; it can promote collagen production and fibroblast proliferation, thus having anti-aging effects on the skin; it also has a moisturizing effect, which can help improve dry skin; the matrine and other components in Sophora flavescens root have strong antioxidant activity, which can scavenge free radicals, reduce damage caused by oxidative stress, protect cells from oxidative damage, and are beneficial for beauty and skin care, improving dry skin and yellowing skin.

[0020] The following are examples of innovative preparation processes for four plant extracts: gentian root, Stephania tetrandra, Peppermint root, and Sophora flavescens root. These processes, while preserving the active ingredients in the extracts, emphasize extraction efficiency, safety, and simplicity, meeting the requirements of industrial production.

[0021] I. Preparation process of gentian root extract Raw material preparation: Dry gentian root is pulverized into powder and screened to a particle size of less than 60 mesh.

[0022] Process steps: Selection of extraction solvent: 70% ethanol-water mixed solvent (volume ratio 1:1) is used as the extraction solvent to ensure the dissolution of polar components.

[0023] Extraction conditions: Add gentian root powder and extraction solvent to the extraction tank at a ratio of 1:10 (mass ratio), and extract ultrasonically for 30 minutes at a temperature of 50℃.

[0024] Filtration and concentration: The extract is filtered to remove solid impurities, and the filtrate is concentrated to 1 / 3 of its original volume. Vacuum concentration is used to avoid high temperature damage to the active ingredients.

[0025] Purification and drying: The concentrate was dried under low temperature vacuum or by spray drying to obtain powdered gentian root extract.

[0026] II. Preparation process of Stephania tetrandra extract Raw material preparation: Crush the dried root and stem of Stephania tetrandra into fine powder, with the particle size controlled at 60 mesh.

[0027] Process steps: Extraction solvent: 70% ethanol-water solution (volume ratio 1:1) is used as the extraction solvent.

[0028] Extraction process: Add the powder of Stephania tetrandra and the extraction solvent to the extractor at a ratio of 1:10 (mass ratio), and use reflux extraction method. The temperature is controlled at 60℃ for 2 hours.

[0029] Filtration and concentration: After filtration, the extract is concentrated to 1 / 3 of its original volume by vacuum concentration to avoid component degradation.

[0030] Drying: Powder extracts are prepared by freeze drying or spray drying to ensure the stability of active ingredients.

[0031] III. Preparation process of Kava pepper root extract Raw material preparation: Dry and grind kava pepper roots into powder with a particle size of less than 60 mesh.

[0032] Process steps: Extraction solvent: 70% ethanol-water solution (volume ratio 1:1) is selected as the extraction solvent.

[0033] Extraction conditions: Add the powder and extractant to the extraction tank at a ratio of 1:10 (mass ratio), and extract ultrasonically for 30 minutes at a temperature of 50℃.

[0034] Filtration and concentration: After filtration, the extract is concentrated under reduced pressure to 1 / 3 of its original volume, and kept at a low temperature to protect the active ingredients.

[0035] Drying: The extract is obtained by spray drying or freeze drying.

[0036] IV. Preparation process of Sophora flavescens root extract Raw material preparation: Dry and grind the Sophora flavescens root into fine powder, with the particle size controlled at 60 mesh.

[0037] Process steps: Extraction solvent: 70% ethanol-water solution (volume ratio 1:1) is used as the extraction solvent.

[0038] Extraction process: Add the powder and extractant to the extractor at a ratio of 1:10 (mass ratio), use reflux extraction, control the temperature at 60℃, and continue for 2 hours.

[0039] Filtration and concentration: After filtration, the extract is concentrated to 1 / 3 of its original volume by vacuum concentration to avoid thermal degradation.

[0040] Drying: The extract is prepared by spray drying or low-temperature vacuum drying to obtain a powdered extract.

[0041] Summary: The above extraction processes all employ mild methods such as low-temperature, reduced-pressure concentration, spray drying, or vacuum drying to ensure the integrity and stability of the plant's active ingredients. The extraction solvent chosen is 70% ethanol-water, balancing the extraction efficiency of polar components while avoiding the safety risks associated with residual organic solvents. The process is simple, easy to industrialize, and meets the safety, stability, and efficiency requirements of this invention for the extract.

[0042] This invention achieves better anti-allergic, repairing, and moisturizing effects by adding gentian root extract, fangchi extract, kava root extract, and sophora root extract to the composition and controlling their mass ratio, without the need for additional antibacterial agents, thus regulating the skin's microecology.

[0043] Compared with the prior art, the beneficial effects of the present invention are as follows: 1) This invention uses a mixture of various plant extracts during implementation to achieve anti-allergic, anti-inflammatory, repairing, and moisturizing effects. Gentian root extract, Stephania tetrandra extract, Kava root extract, Sophora flavescens root extract, Polygonum cuspidatum root extract, chamomile extract, and calendula extract are added to the composition. By controlling their mass ratios, the resulting composition exhibits better anti-allergic, repairing, and moisturizing effects, and can achieve the effect of adjusting the skin's microecology without the need for additional antibacterial agents. Plant extracts have antibacterial and repairing effects, which can fundamentally solve the problem of skin allergies. 2) The skin care composition with synergistic anti-allergic effects provided by this invention is highly effective and safe. It has excellent antibacterial and anti-allergic effects with very little additives and the effects last a long time. When skin care products use the skin care composition with synergistic anti-allergic effects provided by this invention, there is no need to add other preservatives, allergic reactions are less likely to occur, it is highly safe and has a wide range of applications. Detailed Implementation

[0044] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the tables in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0045] This invention discloses a skincare composition with synergistic anti-allergic effects and skincare products containing the same. Through the precise selection and proportioning of specific plant extracts, the composition achieves synergistic effects among its components, resulting in not only excellent immediate anti-allergic and repairing effects, but also multiple benefits such as moisturizing, antibacterial, antioxidant, and whitening. Furthermore, the formula is gentle and highly safe.

[0046] A skincare composition with synergistic anti-allergic effects, comprising, by weight, 10-25 parts of plant extracts, 10-15 parts of moisturizers, and 50-90 parts of water; wherein the plant extracts include gentian root extract, Stephania tetrandra extract, Peppermint root extract, and Sophora flavescens root extract.

[0047] Preferably, the mass ratio of the gentian root extract, the stephania tetrandra extract, the kava root extract, and the sophora flavescens root extract is (2-4): (2-4): (2-4): (0.5-2).

[0048] The humectant is a mixture of 1,3-butanediol and 1,2-hexanediol. 1,3-Butanediol is the main moisturizing ingredient, while 1,2-hexanediol has both moisturizing and mild preservative functions.

[0049] The preparation method of the above-mentioned skin care composition with synergistic anti-allergic effects includes the following steps: 1) Mix water, 1,2-hexanediol and 1,3-butanediol to obtain a mixture; 2) Add gentian root extract, fangchi extract, kava root extract and sophora root extract to the mixture obtained in step 1), keep the temperature at 25℃-30℃ and stir evenly until the solution is clear and transparent to obtain the skin care composition with synergistic anti-allergic effect.

[0050] This invention also provides the application of the above-mentioned skin care composition in the preparation of skin care products such as lotions, serums, creams, and toners.

[0051] This invention innovatively combines four extracts—Gentian root, Stephania tetrandra, Kava root, and Sophora flavescens root—in a scientifically proportioned ratio. Gentian root and Kava root focus on immediate soothing, reducing neuronal stimulation, and relieving itching; Stephania tetrandra excels at astringing and inhibiting inflammatory responses; and Sophora flavescens root focuses on antibacterial, antioxidant, and repair-promoting effects. The four extracts work synergistically, inhibiting irritant signals, reducing inflammation, repairing the skin barrier, and regulating the microecological pathways, achieving a synergistic anti-allergic effect greater than the sum of its parts ("1+1+1+1>4"), fundamentally solving skin sensitivity problems.

[0052] This composition is not only anti-allergenic, but also has excellent moisturizing, repairing, antioxidant, tyrosinase-inhibiting, and mild antiseptic effects, meeting the multiple skincare needs of sensitive skin.

[0053] High safety: The formula is simple and natural, utilizing the antibacterial properties of plant extracts and the preservative properties of 1,2-hexanediol. There is no need to add traditional chemical preservatives, which greatly reduces the risk of product sensitization. It is gentle and safe and suitable for all types of skin, including sensitive skin.

[0054] Stable formulation: The preparation process is simple and the conditions are mild. The resulting composition is clear and transparent, has good stability, is easy to industrialize, and can be applied to various dosage forms of skin care products.

[0055] The following examples and comparative examples illustrate the compositions of the present invention in more detail, but the present invention is not limited thereto.

[0056] Examples 1-3 The skincare composition of the present invention was prepared according to the formulation (parts by weight) shown in Table 1 below.

[0057] A skincare composition with synergistic anti-allergic effects, comprising, by weight, the formulation components shown in Table 1 below.

[0058] Table 1: Formulation Table for Examples 1-3

[0059] Preparation method: 1) Mix water, 1,2-hexanediol and 1,3-butanediol in a stirred tank to obtain a homogeneous mixture; 2) Slowly add gentian root extract, fangchi extract, kava root extract and sophora root extract to the mixture obtained in step 1), keep the temperature at 25-30℃, and stir at a medium speed for about 30-45 minutes until the solution is completely clear and transparent, thus obtaining the skin care composition with synergistic anti-allergic effects.

[0060] Comparative Example 1 A single gentian root extract composition: 13 parts gentian root extract, 0.2 parts 1,2-hexanediol, 10 parts 1,3-butanediol, and 76.8 parts water. The preparation method is the same as in Example 1.

[0061] Comparative Example 2 Composition lacking Sophora flavescens root extract: 4 parts Gentiana scabra root extract, 4 parts Stephania tetrandra extract, 5 parts Piper kava root extract, 0.2 parts 1,2-hexanediol, 10 parts 1,3-butanediol, and 76.8 parts water. Preparation method is the same as in Example 1.

[0062] Comparative Example 3 Commercially available anti-allergy ingredient composition (replacing the plant group of this invention): 0.5 parts bisabolol, 0.5 parts dipotassium glycyrrhizate, 0.2 parts 1,2-hexanediol, 10 parts 1,3-butanediol, and 89.8 parts water.

[0063] The preparation method is the same as in Example 1.

[0064] Efficacy Experimental Cases Experimental Example 1: Irritation / Corrosion Test (Acute Eye Irritation Test) 1) Test substance: The samples prepared in Examples 1-3 and Comparative Examples 1-3 were diluted to 1.5% (w / w) using 0.9% sodium chloride solution.

[0065] 2) Experimental animals and environment: Animal species: Common-grade New Zealand rabbits, weighing 2.0-2.5kg, provided by [XXX Biotechnology Co., Ltd.], production license number: SCXK (Shanghai) 2023-0008. A total of 21 rabbits were used, divided into 7 groups (Example 1-3 groups, Comparative Examples 1-3 groups), with 3 rabbits in each group.

[0066] Experimental environment: Temperature (T): 20-24℃, Relative humidity (%RH): 50-65%.

[0067] 3) Test Procedure: The procedure was conducted according to the "Cosmetic Safety Technical Specifications" (2015 edition). Animal eyes were examined 24 hours prior to the test and no abnormalities were found. 0.1 mL of the test substance was instilled into the conjunctival sac of one eye, with the other eye serving as a control. The reactions of the cornea, iris, and conjunctiva were observed and scored at 1 hour, 24 hours, 48 ​​hours, and 72 hours after instillation.

[0068] 4) Result evaluation: Calculate the mean stimulus integral at each time point, and evaluate the stimulus intensity based on the highest integral and recovery status.

[0069] The results are shown in Table 2 below.

[0070] Table 2: Results of Acute Eye Irritation Tests

[0071] Conclusion: The compositions prepared in Examples 1-3 of this invention are all non-irritating and have extremely high safety. Comparative Examples 1 and 2 (single component or incomplete formulation) showed mild irritation, demonstrating that the synergistic effect of the complete formulation of this invention is crucial for reducing the potential irritation of the product.

[0072] Experiment Example 2: Tyrosinase Inhibition Effect Test 1) Experimental principle: The mushroom tyrosinase dopa rate oxidation method was used to determine the inhibition rate of the sample on tyrosinase activity in order to evaluate its whitening and spot-fading potential.

[0073] 2) Experimental Method: The method of Arung ET et al. (2009) was followed with slight modifications. In a 96-well plate, phosphate buffer (pH 6.8), different concentrations of the test substance solution (the composition of Example 1), and tyrosinase solution were added. After incubation at 37°C for 10 min, L-DOPA was added to initiate the reaction, and the increase in absorbance per minute was measured at 492 nm. Arbutin was used as a positive control to calculate the tyrosinase inhibition rate.

[0074] 3) Experimental results: as shown in Table 3 below.

[0075] Table 3: Results of Tyrosinase Inhibition Rate Test (n=3)

[0076] Conclusion: The skincare composition of this invention exhibits a significant concentration-dependent inhibitory effect on tyrosinase activity, with an inhibition rate as high as 76.3% at a concentration of 200 μg / mL, which is superior to the classic whitening agent arbutin at the same concentration. This verifies the whitening and spot-fading effects of extracts such as gentian root and sophora root described in the instructions, indicating that this anti-allergic composition also possesses excellent whitening potential.

[0077] Experiment Example 3: Evaluation of Synergistic Anti-allergic Effect (In Vitro Cell Model) 1) Experimental Principle: An in vitro inflammation model was established by stimulating human immortalized keratinocytes (HaCaT) with lipopolysaccharide (LPS) to simulate a sensitive skin state. The anti-inflammatory and soothing effects of the samples were evaluated by detecting the release of the key inflammatory factor interleukin-6 (IL-6) in the cell supernatant.

[0078] 2) Experimental method: HaCaT cells were divided into 6 groups: ① Normal control group (culture medium only), ② Model group (LPS stimulation), ③ Positive control group (LPS + 1μM dexamethasone), ④ Example 1 group (LPS + 0.1% Example 1), ⑤ Comparative example 1 group (LPS + 0.1% Comparative example 1), ⑥ Comparative example 2 group (LPS + 0.1% Comparative example 2).

[0079] After pretreatment of the samples for 1 hour, LPS (1 μg / mL) was added and the cells were co-cultured for 24 hours. The IL-6 content in the cell supernatant was detected using an ELISA kit.

[0080] 3) Experimental results: as shown in Table 4 below.

[0081] Table 4: Inhibition rate of IL-6 release from HaCaT cells (n=3, x±s)

[0082] Note: Compared with the model group, *P<0.05, **P<0.01.

[0083] Conclusion: The composition of Example 1 of this invention can significantly inhibit the release of the inflammatory factor IL-6, with an inhibition rate as high as 57.3%, and its effect is close to that of the potent anti-inflammatory drug dexamethasone, and is significantly superior to Comparative Example 1 (single component) and Comparative Example 2 (incomplete formulation). This result strongly demonstrates that the extracts of Gentiana scabra root, Stephania tetrandra root, Peppermint root, and Sophora flavescens root have a significant synergistic effect in anti-allergy and anti-inflammatory effects, and none of them can be omitted.

[0084] In summary, the skincare composition provided by this invention achieves synergistic enhancement of multiple effects such as anti-allergy, soothing, repair, moisturizing, and whitening through the scientific combination of four specific plant extracts. It is also highly safe, has a stable formula, and has broad application prospects.

[0085] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A skincare composition with synergistic anti-allergic effects, characterized in that, The ingredients, by weight, are as follows: 10-25 parts plant extract, 10-15 parts moisturizer and 50-90 parts water; The plant extract is selected from a mixture of gentian root extract, tetrapanax root extract, kava root extract and sophora root extract, and the mass ratio of the four is (5-10):(5-10):(5-10):(1-5).

2. The skincare composition according to claim 1, characterized in that: The plant extract comprises 15-22 parts, the moisturizer 10-12 parts, and the water 60-80 parts.

3. The skincare composition according to claim 1 or 2, characterized in that: The mass ratio of the gentian root extract, the stephania tetrandra extract, the kava root extract, and the sophora flavescens root extract is (6-8):(6-8):(6-8):(2-4).

4. The skincare composition according to claim 3, characterized in that: The mass ratio of the gentian root extract, the stephania tetrandra extract, the kava root extract, and the sophora flavescens root extract is 4:4:4:

1.

5. The skincare composition according to any one of claims 1-4, characterized in that: The humectant is a mixture of 1,2-hexanediol and 1,3-butanediol in a mass ratio of 1:(50-80).

6. The skincare composition according to claim 5, characterized in that: The mass ratio of 1,2-hexanediol to 1,3-butanediol is 1:

50.

7. The skincare composition according to any one of claims 1-6, characterized in that: It comprises the following components by weight: Gentian root extract 4 parts, Stephania tetrandra extract 4 parts, Pepper root extract 4 parts, Sophora flavescens root extract 1 part, 1,2-hexanediol 0.2 parts, 1,3-butanediol 10 parts and water 76.8 parts.

8. The skincare composition according to claim 7, characterized in that: The preparation process of the gentian root extract is as follows: Raw material preparation: Dry gentian root is pulverized into powder, and the particle size is screened to within 60 mesh; Process steps: Extraction solvent selection: 70% ethanol-water mixed solvent (volume ratio 1:1) is used as the extraction solvent to ensure the dissolution of polar components; Extraction conditions: Gentian root powder and extraction solvent are added to the extraction tank at a ratio of 1:10 (mass ratio), and ultrasonic extraction is performed for 30 minutes at a temperature controlled at 50℃; Filtration and concentration: The extract is filtered to remove solid impurities, and the filtrate is concentrated to 1 / 3 of its original volume using vacuum concentration to avoid high temperature damage to active ingredients; Purification and drying: The concentrated solution is dried by low-temperature vacuum drying or spray drying to obtain powdered gentian root extract; The preparation process of the Stephania tetrandra extract is as follows: Raw material preparation: The dried rhizomes of Stephania tetrandra are pulverized into a fine powder with a particle size controlled at 60 mesh; Process steps: Extraction solvent: 70% ethanol-water solution (volume ratio 1:1) is used as the extractant; Extraction process: Stephania tetrandra powder and extraction solvent are added to the extractor at a ratio of 1:10 (mass ratio), and reflux extraction is performed at a temperature controlled at 60℃ for 2 hours; Filtration and concentration: After filtration, the extract is concentrated to 1 / 3 of its original volume under reduced pressure to avoid component degradation; Drying: Freeze-drying or spray drying is used to prepare a powder extract to ensure the stability of the active ingredients; The preparation process of the kava root extract is as follows: Raw material preparation: Kava pepper root is dried and pulverized to a particle size of less than 60 mesh; Process steps: Extraction solvent: 70% ethanol-water solution (volume ratio 1:1) is selected as the extractant; Extraction conditions: The powder and extractant are added to the extraction tank at a ratio of 1:10 (mass ratio), and ultrasonic extraction is carried out for 30 minutes while the temperature is controlled at 50℃; Filtration and concentration: After filtration, the extract is concentrated under reduced pressure to 1 / 3 of the original volume, and the low temperature is maintained to protect the active ingredients; Drying: The extract is obtained by spray drying or freeze drying. The preparation process of the Sophora flavescens root extract is as follows: Raw material preparation: Sophora flavescens root is dried and pulverized into a fine powder with a particle size controlled at 60 mesh; Process steps: Extraction solvent: 70% ethanol-water solution (volume ratio 1:1) is used as the extractant; Extraction process: The powder and extractant are added to the extractor at a ratio of 1:10 (mass ratio), and reflux extraction is carried out at a temperature controlled at 60℃ for 2 hours; Filtration and concentration: After filtration, the extract is concentrated to 1 / 3 of its original volume by vacuum concentration to avoid thermal degradation; Drying: The extract is prepared by spray drying or low-temperature vacuum drying to obtain a powdered extract.

9. A method for preparing a skincare composition according to any one of claims 1-8, characterized in that, Includes the following steps: 1) Mix water, 1,2-hexanediol and 1,3-butanediol to obtain a mixture; 2) Add gentian root extract, fangchi extract, kava root extract and sophora root extract to the mixture obtained in step 1), keep the temperature at 25℃-30℃ and stir evenly until the solution is clear and transparent to obtain the skin care composition.

10. A skincare product, characterized in that, The skincare composition comprising any one of claims 1-8; the use of the skincare composition in the preparation of skincare products for anti-allergy, repair, moisturizing or regulating skin microbiome.

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