Anti-allergy composition as well as preparation method and application thereof

Abstract

The invention relates to an anti-allergy composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The invention provides an anti-allergy composition which comprises a radix gentianae extract, a piper nigrum root extract and an opuntia streptacantha leaf extract, and the mass ratio of the radix gentianae extract to the piper nigrum root extract to the opuntia streptacantha leaf extract is (0.5-67): (0.05-34): 1. The radix gentianae extract, the piper nigrum root extract and the opuntia streptacantha leaf extract are matched to form the anti-allergy composition, the problem that the piper nigrum root extract is poor in water solubility can be effectively solved, the anti-allergy composition has the anti-oxidation, anti-allergy and anti-inflammatory effects, and the anti-allergy effect is synergistically achieved.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-allergic composition, its preparation method, and its application. Background Technology

[0002] With increasing environmental pollution, rising life pressures, and frequent use of cosmetics, sensitive skin has become a global problem. Sensitive skin refers to a hyperreactive state of the skin under physiological or pathological conditions. It is mainly manifested as burning, stinging, itching, and tightness when stimulated by physical, chemical, or psychological factors, with or without objective symptoms such as erythema, scaling, and telangiectasia.

[0003] Studies have shown that the core mechanisms of skin sensitivity are closely related to impaired skin barrier function, overactive sensory nerves, and an imbalance in the immune-inflammatory response. Specifically, external stimuli (such as pollutants, fragrances, and preservatives) or endogenous mediators (such as neuropeptides) can activate sensory nerve endings and immune cells (such as mast cells) in the skin, leading to abnormal activation of "itch / pain" receptor channels such as transient receptor potential vanillic acid subtype 1 (TRPV1) and triggering neurogenic inflammation. Simultaneously, mast cells and other immune cells release large amounts of inflammatory mediators such as histamine, leukotrienes, and prostaglandins, further exacerbating nerve ending sensitization and vascular responses, creating a vicious cycle that ultimately results in the skin remaining in a state of sensitivity and inflammation.

[0004] Natural plants contain abundant active ingredients such as polyphenols, flavonoids, terpenes, and polysaccharides. These ingredients typically have multiple biological functions, including anti-inflammatory, antioxidant, barrier repair, and immune regulation. Theoretically, they can intervene more comprehensively in the chain of occurrence and development of skin sensitivity through synergistic effects of multiple pathways and multiple targets.

[0005] However, many publicly available natural anti-allergy ingredients still have the following shortcomings: ① Single efficacy: Most formulas only focus on single effects such as anti-inflammation or anti-oxidation, and do not pay enough attention to higher-level anti-allergy targets such as inhibiting neurogenic inflammation and calming nerve endings. ② Poor synergy: Simple accumulation of plant ingredients, lacking in-depth research and scientific formulation of synergistic effects between ingredients, resulting in an overall effect of "1+1<2".

[0006] Therefore, there is an urgent need to develop an anti-allergy composition based on natural plants. This composition should be able to act simultaneously and efficiently on multiple key aspects such as "soothing and barrier repair," thereby providing a fast, long-lasting, and comprehensive anti-allergy solution while ensuring absolute safety. Summary of the Invention

[0007] The purpose of this invention is to overcome the shortcomings of the prior art and provide an anti-allergic composition with soothing and barrier repair effects, as well as its preparation method and application.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides an anti-allergic composition comprising gentian root extract, kava root extract and prickly pear leaf extract, wherein the mass ratio of the gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = (0.5-67): (0.05-34): 1.

[0009] This invention combines gentian root extract, kava root extract, and prickly pear leaf extract into an anti-allergy composition, which effectively solves the problem of poor water solubility of kava root extract and has soothing and barrier repair effects, synergistically achieving anti-allergy efficacy.

[0010] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of the gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = (1-50): (0.1-25): 1.

[0011] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of the gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = (1.5-30): (0.5-15): 1.

[0012] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of the gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = (2.5-20): (0.8-10): 1.

[0013] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of the gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = (4-10): (1.5-7): 1.

[0014] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of the gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = 5:3:1.

[0015] As a preferred embodiment of the anti-allergic composition of the present invention, the gentian root extract is mainly prepared by fermenting gentian root, water, Lactobacillus plantarum and Lactobacillus helveticus, followed by sterilization and centrifugation.

[0016] As a preferred embodiment of the anti-allergic composition of the present invention, the *Lactobacillus plantarum* has the accession number CICC20261, and the *Lactobacillus helveticus* has the accession number CICC 20241.

[0017] As a preferred embodiment of the anti-allergic composition of the present invention, the method for preparing the gentian root extract includes the following operations: (1) Gentian root and water are mixed and sterilized to obtain fermentation substrate, wherein the mass ratio of gentian root to water is gentian root: water = 1: (10-300). (2) Lactobacillus helveticus (CICC 20243) and Lactobacillus plantarum (CICC 20261) were prepared to have a viable count of 10⁻⁶. 9 ~10 13 CFU / mL bacterial culture was inoculated into the fermentation substrate obtained in step (1). The inoculation amount was 1-3 mL of bacterial culture per 300 mL of fermentation substrate. The culture was kept at a constant temperature of 35-45℃ for 12-24 h. After the fermentation culture was completed, the culture was sterilized, cooled to room temperature, and then centrifuged. The supernatant was sterilized again and cooled to 75℃. Preservatives were added to prepare gentian root extract. The preservatives included p-hydroxyacetophenone and 1,2-hexanediol.

[0018] As a preferred embodiment of the anti-allergic composition of the present invention, the kava pepper root extract contains a solubilizer.

[0019] In a preferred embodiment of the anti-allergic composition of the present invention, the solubilizer includes at least one selected from polyglycerol-10 laurate, lauryl ether-9, polysorbate-20, PEG-40 hydrogenated castor oil, and polysorbate-80. Through screening different types of solubilizers, the present invention found that polyglycerol-10 laurate has the best solubilizing effect on kava root extract, resulting in a yellow, transparent liquid in the prepared anti-allergic composition. Other solubilizers also have good solubilizing effects on kava root extract, resulting in a yellow, slightly turbid liquid in the anti-allergic composition. The combination of kava root extract with added solubilizer, gentian root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid, and rhamnose results in a more stable anti-allergic composition. Without the addition of kava root extract and solubilizer, it is impossible to mix it evenly with the other combinations to prepare a homogeneous liquid.

[0020] In a preferred embodiment of the anti-allergic composition of the present invention, the solubilizer is polyglycerol-10 laurate.

[0021] In a preferred embodiment of the anti-allergic composition of the present invention, the mass of the solubilizer is 1-15 wt% of the total mass of the kava pepper root extract.

[0022] In a preferred embodiment of the anti-allergic composition of the present invention, the solubilizer accounts for 3-10 wt% of the total mass of the kava pepper root extract.

[0023] In a preferred embodiment of the anti-allergic composition of the present invention, the solubilizer accounts for 8 wt% of the total mass of the kava pepper root extract.

[0024] In a preferred embodiment of the anti-allergic composition of the present invention, the anti-allergic composition further includes tetrahydromethylpyrimidine carboxylic acid and rhamnose. Experiments have shown that adding tetrahydromethylpyrimidine carboxylic acid and rhamnose to the anti-allergic composition can further enhance its redness-reducing and soothing effects, and synergistically improve its soothing and barrier-repairing effects.

[0025] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of tetrahydromethylpyrimidine carboxylic acid and rhamnose in the anti-allergic composition is tetrahydromethylpyrimidine carboxylic acid: rhamnose = 1: (0.1-10).

[0026] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of tetrahydromethylpyrimidine carboxylic acid and rhamnose in the anti-allergic composition is tetrahydromethylpyrimidine carboxylic acid: rhamnose = 1: (0.46-2.1).

[0027] In a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of tetrahydromethylpyrimidine carboxylic acid and rhamnose in the anti-allergic composition is tetrahydromethylpyrimidine carboxylic acid: rhamnose = 1:1.

[0028] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = (0.5-67): (0.05-34): 1: (0.5-335): (0.5-335).

[0029] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = (1-50): (0.1-25): 1: (1-300): (1-300).

[0030] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = (1.5-30): (0.5-15): 1: (10-200): (10-200).

[0031] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = (2.5-20): (0.8-10): 1: (25-160): (25-160).

[0032] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = (4-10): (1.5-7): 1: (40-100): (40-100).

[0033] As a preferred embodiment of the anti-allergic composition of the present invention, the mass ratio of gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = 5:3:1:50:50.

[0034] Secondly, the present invention provides a method for preparing the above-mentioned anti-allergic composition, comprising the following steps: (1) When the anti-allergic composition includes gentian root extract, kava root extract and prickly pear leaf extract, it includes the following steps: Gentian root extract, kava root extract and prickly pear leaf extract were mixed to obtain an anti-allergic composition; or, (2) When the anti-allergic composition includes gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose, it includes the following steps: S1. Mix gentian root extract, kava root extract and prickly pear leaf extract to obtain mixture a; S2. Mix the mixture a obtained in step S1 with tetrahydromethylpyrimidine carboxylic acid and rhamnose at 55-65°C to obtain an anti-allergic composition.

[0035] Thirdly, the present invention provides the application of the above-mentioned anti-allergic composition in the preparation of cosmetics.

[0036] As a preferred embodiment of the application described in this invention, the dosage form of the cosmetic includes at least one of cream, lotion, aqueous solution, gel, oil, powder, block powder or solid, patch, film and freeze-dried.

[0037] Fourthly, the present invention provides an anti-allergic cosmetic, the cosmetic comprising the above-mentioned anti-allergic composition.

[0038] In a preferred embodiment of the cosmetic described in this invention, the cosmetic also includes excipients.

[0039] In a preferred embodiment of the cosmetic described in this invention, the excipients include, but are not limited to, at least one of solubilizers, antioxidants, and moisturizers.

[0040] As a preferred embodiment of the cosmetic of the present invention, the solubilizer includes, but is not limited to, at least one of polyglycerol-10 lauryl ester, Tween-20 and polyglycerol-6 octanoate.

[0041] As a preferred embodiment of the cosmetic of the present invention, the antioxidant includes, but is not limited to, at least one of 1,2-pentanediol, 1,2-hexanediol and p-hydroxyacetophenone.

[0042] As a preferred embodiment of the cosmetic described in this invention, the moisturizer includes, but is not limited to, at least one of glycerin, butylene glycol, propylene glycol, and squalane.

[0043] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention combines gentian root extract, kava root extract, and prickly pear leaf extract into an anti-allergy composition, which effectively solves the problem of poor water solubility of kava root extract and has a soothing and barrier-repairing effect, thus synergistically achieving anti-allergy efficacy. Attached Figure Description

[0044] Figure 1 This is a product diagram of Embodiment 1 of the present invention; Figure 2 This is a product diagram of Embodiment 2 of the present invention. Detailed Implementation

[0045] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0046] Unless otherwise specified, all other materials and reagents used in the examples, comparative examples, and effect examples are commercially available.

[0047] The INCI names of the cosmetic ingredients mentioned below are shown in Table 1, and all of them are commercially available.

[0048] The cosmetic ingredient gentian root extract mentioned below is mainly obtained by fermenting and culturing gentian root, water, *Lactobacillus plantarum* and *Lactobacillus helveticus*, followed by sterilization, in accordance with paragraphs

[0064] -

[0066] of the instruction manual CN 118319811 A, specifically including the following operations: (1) Gentian root was mixed with deionized water and then sterilized to obtain fermentation substrate; (2) Lactobacillus helveticus (CICC 20243) and Lactobacillus plantarum (CICC 20261) were prepared to have a viable count of 10⁻⁶. 10 CFU / mL bacterial culture was inoculated into the fermentation substrate obtained in step (1). The inoculation amount was 1 mL of bacterial culture per 300 mL of fermentation substrate. The culture was incubated at a constant temperature of 40℃ for 15 h. After the fermentation culture was completed, the culture was sterilized, cooled to room temperature, and then centrifuged. The supernatant was sterilized a second time and cooled to 75℃. Preservatives were added to prepare gentian root extract. The preservatives included p-hydroxyacetophenone and 1,2-hexanediol, wherein the mass percentage of p-hydroxyacetophenone in the supernatant was 0.5% and the mass percentage of 1,2-hexanediol in the supernatant was 0.5%.

[0049] Table 1. Names of Cosmetic Raw Materials and Their INCI Names Examples 1-5 Examples 1-5 provide an anti-allergic composition and its preparation method, respectively. The anti-allergic composition includes gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid, and rhamnose, with a mass ratio of gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = 5:3:1:50:50. The kava root extract contains a solubilizer, and the types and amounts of the solubilizers are shown in Table 2. The preparation method includes the following steps: S1. Mix and stir the gentian root extract, kava root extract and prickly pear leaf extract for 10 minutes to obtain mixture a; S2. The mixture a obtained in step S1 is stirred and dissolved with tetrahydromethylpyrimidine carboxylic acid and rhamnose at 60°C, kept at this temperature for 30 min, and then cooled to 38°C to obtain the anti-allergic composition.

[0050] Table 2. Types and dosages of solubilizers in different kava root extracts. Examples 8-13 and Comparative Examples 1-6 Examples 8-13 and Comparative Examples 1-6 respectively provide an anti-allergic composition and its preparation method. The components and their amounts of the anti-allergic composition are shown in Table 3. The solubilizer contained in the kava root extract is polyglycerol-10 laurate (8 wt% of the total mass of the kava root extract). The preparation method is the same as in Example 1.

[0051] Table 3. Components and dosages (mass ratio) of different anti-allergy compositions Comparative Example 7 Comparative Example 7 provides an anti-allergic composition and its preparation method. The components and amounts of the anti-allergic composition are similar to those of Example 1, except that the gentian root extract is replaced with centella asiatica extract. The preparation method is the same as that of Example 1, and the remaining components and their amounts remain unchanged.

[0052] Comparative Example 8 Comparative Example 8 provides an anti-allergic composition and its preparation method. The components and amounts of the anti-allergic composition are similar to those of Example 1, except that rhamnose is replaced with xylitol. The preparation method is the same as that of Example 1, and the remaining components and their amounts remain unchanged.

[0053] Example 1 The anti-allergic compositions obtained in Examples 1-7 were subjected to stability testing, and the specific procedures are as follows: Take 30g of the anti-allergic compositions obtained in Examples 1-7 respectively and place them in a constant temperature incubator at 45±2℃ or -(18±2)℃ for 2 months to observe the appearance changes of the anti-allergic compositions. At the same time, perform a cyclic test of placing at 45℃ for 1 week → placing at room temperature for 1 week → placing at -18℃ for 1 week. After completing 3 cycles, observe the appearance changes of the anti-allergic compositions. The results are shown in Table 4. The product image of the anti-allergic composition obtained in Example 1 is shown in Table 4. Figure 1 The product image of the anti-allergic composition obtained in Example 2 is shown below. Figure 2 .

[0054] Table 4. Stability test results of different anti-allergy compositions As shown in Table 4, when polyglycerol-10 laurate is used as the solubilizer in kava pepper root extract, it can effectively improve its solubility in anti-allergic compositions, and similar solubility is also achieved when the amount of polyglycerol-10 laurate added is 3-10 wt%.

[0055] Example 2 To verify the efficacy of the anti-allergic compositions obtained in Examples 1, 8-13, and Comparative Examples 1-8, in vitro experiments were conducted, and the specific procedures are as follows: 1. Soothes (reddens).

[0056] Studies have shown that hyaluronidase is involved in type I hypersensitivity reactions and is strongly correlated with inflammation and allergies. Following the Elson-Morgan hyaluronidase inhibition assay, a 1.2 mg / mL sample was reacted with hyaluronidase at 37°C in the presence of calcium chloride and potassium hyaluronate. The resulting reaction product was then developed with the chromogenic reagent P-DAB, and its absorbance was measured at 530 nm using a UV-Vis spectrophotometer. The results were then calculated and converted into a hyaluronidase inhibition rate. The results are shown in Table 5.

[0057] Table 5. Soothing test results of different anti-allergy compositions

[0058] As shown in Table 5, the hyaluronidase inhibition rates of the examples were all higher than those of the comparative examples, indicating that the anti-allergic composition of the present invention has a better soothing effect. Compared with Comparative Example 1, the hyaluronidase inhibition rate of Example 13 was even higher, indicating that only under specific ratio ranges can the anti-allergic composition composed of gentian root extract, kava root extract and prickly pear cactus extract exert a better soothing effect.

[0059] Compared with Comparative Examples 2-8, the anti-allergy composition of the Examples has a higher hyaluronidase inhibition rate, indicating that only when gentian root extract, pepper kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose are combined in a specific ratio range to form an anti-allergy composition can the synergistic effect of increasing the hyaluronidase inhibition rate be achieved, thereby achieving a soothing effect.

[0060] 2. Repair performance test Cell migration ability directly reflects the cell's activity level. If cells can proliferate and migrate rapidly, they can quickly form a protective mechanism to repair damaged cells in response to external stimuli. The cell scratch (repair) method is a simple way to measure cell migration and repair ability. Similar to an in vitro wound healing model, on a monolayer of adherent cells cultured in an in vitro culture dish or plate, a line is drawn in the central area of ​​cell growth using a micropipette tip or other hard object. The cells in the central part are removed, and the cells are cultured again until the experimental time is set. Then, the cell culture plate is removed, and it is observed whether the surrounding cells have grown (repaired) to the central scratch area, thus judging the cell's repair ability. The experiment usually requires a normal control group and an experimental group. The experimental group is a group with a certain treatment factor, drug, exogenous gene, etc. By comparing the repair ability of cells in different groups to the scratch area, the migration and repair ability of cells in each group can be judged.

[0061] Samples: (1) Negative control: DMEM culture medium containing 10 v / v% serum; (2) Sample group: anti-allergy compositions of Examples 1, 8-13, and anti-allergy compositions of Comparative Examples 1-8, prepared into a 2% solution by mass using DMEM culture medium containing 10% serum as a solvent.

[0062] Experimental Procedure: HaCaT human keratinocytes were seeded into 12-well plates (100,000 cells / well) and cultured at 37°C for 24 hours. After culture, the original culture medium in the wells was discarded, and two longitudinal and two transverse scratches were made in each well using a pipette tip. 100 μL of DMEM culture medium containing 1% v / v serum was added to the negative control group, and 100 μL of the prepared sample solution was added to each well of the sample group. The cells were cultured for 18 hours. Samples were taken at time points 0 and 18 hours, photographed, and three regions were randomly selected to calculate the mean area of ​​the intercellular scratches.

[0063] Cell migration rate (wound healing rate) was calculated by the average intercellular scratch area at 0h and 18h. The cell migration rate (wound healing rate) expresses the repair effect of the sample. The higher the cell migration rate (wound healing rate), the better the repair effect.

[0064] Cell migration rate (wound healing rate) % = (0h scratch area - 18h scratch area) / 0h scratch area The cell repair test results of different compositions are shown in Table 6.

[0065] Table 6. Barrier repair test results of different anti-allergy compositions As shown in Table 6, the anti-allergy compositions obtained in the examples all exhibited good cell repair capabilities, with Example 1 showing the best effect. Compared to Comparative Example 1, Example 13 showed a higher 18-hour cell migration rate, indicating that only within a specific ratio range can the anti-allergy composition composed of gentian root extract, kava root extract, and prickly pear cactus extract exert a better barrier repair effect.

[0066] Compared with the examples, the cell migration rates of Comparative Examples 2-8 were all lower than those of the examples, indicating that only when gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid, and rhamnose are combined in a specific ratio range to form an anti-allergic composition can a synergistic effect on improving repair be achieved.

[0067] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. An anti-allergic composition, characterized in that, It includes gentian root extract, kava root extract and prickly pear leaf extract, wherein the mass ratio of gentian root extract, kava root extract and prickly pear leaf extract is gentian root extract: kava root extract: prickly pear leaf extract = (0.5-67): (0.05-34):

1.

2. The anti-allergic composition according to claim 1, characterized in that, The gentian root extract is mainly prepared by fermenting gentian root, water, Lactobacillus plantarum and Lactobacillus helveticus, followed by sterilization and centrifugation.

3. The anti-allergic composition according to claim 1, characterized in that, The kava pepper root extract contains a solubilizer.

4. The anti-allergic composition according to claim 3, characterized in that, Includes at least one of the following (I) to (II): (I) The solubilizer includes at least one of polyglycerol-10 laurate, lauryl ether-9, polysorbate-20, PEG-40 hydrogenated castor oil, and polysorbate-80; (II) The mass of the solubilizer is 1-15 wt% of the total mass of the kava pepper root extract.

5. The anti-allergic composition according to claim 1, characterized in that, The anti-allergic composition also includes tetrahydromethylpyrimidine carboxylic acid and rhamnose.

6. The anti-allergic composition according to claim 5, characterized in that, The mass ratio of tetrahydromethylpyrimidine carboxylic acid and rhamnose in the anti-allergic composition is tetrahydromethylpyrimidine carboxylic acid: rhamnose = 1: (0.1-10).

7. The anti-allergic composition according to claim 5, characterized in that, The mass ratio of the gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid, and rhamnose is gentian root extract: kava root extract: prickly pear leaf extract: tetrahydromethylpyrimidine carboxylic acid: rhamnose = (0.5-67): (0.05-34): 1: (0.5-335): (0.5-335).

8. The method for preparing the anti-allergic composition according to any one of claims 1-7, characterized in that, The following options are included: (1) When the anti-allergic composition includes gentian root extract, kava root extract and prickly pear leaf extract, it includes the following steps: Gentian root extract, kava root extract and prickly pear leaf extract were mixed to obtain an anti-allergic composition; or, (2) When the anti-allergic composition includes gentian root extract, kava root extract, prickly pear leaf extract, tetrahydromethylpyrimidine carboxylic acid and rhamnose, it includes the following steps: S1. Mix gentian root extract, kava root extract and prickly pear leaf extract to obtain mixture a; S2. Mix the mixture a obtained in step S1 with tetrahydromethylpyrimidine carboxylic acid and rhamnose at 55-65°C to obtain an anti-allergic composition.

9. The use of the anti-allergic composition according to any one of claims 1-7 in the preparation of cosmetics.

10. An anti-allergic cosmetic, characterized in that, The cosmetic product includes the anti-allergic composition according to any one of claims 1-7.

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