Preparation method of tablets for relaxing muscles and stimulating blood circulation

Abstract

The invention belongs to the technical field of preparation processes, and particularly relates to a preparation method of a tendon-relaxing and blood-activating tablet. The invention provides a preparation method of tablets for relaxing muscles and stimulating blood circulation. The method comprises the following steps: a, carrying out superfine grinding on safflower, vinegar-processed rhizoma cyperi, scalded rhizoma cibotii and cortex periplocae into fine powder; b, adding water into calcined natural copper, decocting, adding Chinese starjasmine stem, lycopodium clavatum, herba lycopi, mistletoe and caulis spatholobi, decocting, combining decoction, filtering, standing, concentrating supernate into extract, drying, crushing and sieving to obtain dry extract powder; and c, placing the fine powder and the dry extract powder in a fluidization chamber of a fluidized bed, carrying out top spraying of an adhesive solution, carrying out fluidized bed granulation, drying, and tabletting to obtain the product. The tablet prepared by the method is regular in shape, tidy in edge and free of unfilled corners and tablet cracking phenomena. The tablet is smooth in surface, free of granular sensation and roughness, uniform in color and free of color spots. The tablet has the advantages of moderate hardness, toughness, no loosening phenomenon, compact overall structure, no damage, no stripping, no crack and no scratch, and friability, disintegration time limit and content result all accord with regulations.

Description

Technical Field

[0001] This invention belongs to the field of preparation technology, specifically relating to a method for preparing muscle-relaxing and blood-activating tablets. Background Technology

[0002] Shujin Huoxue Tablets are a traditional Chinese medicine tablet made from ten Chinese herbs: safflower, vinegar-processed Cyperus rotundus, scalded Cibotium barometz, Periploca sepium, mistletoe, Lycopus lucidus leaf, Spatholobus suberectus, Trachelospermum jasminoides, Lycopodium clavatum, and calcined natural copper. It has the effects of relaxing muscles and tendons, promoting blood circulation and removing blood stasis. It is used for muscle and bone pain, limb contractures, lower back pain, and sprains.

[0003] The existing standard for the preparation method of Shujin Huoxue tablets is as follows: Safflower, Cyperus rotundus, Cibotium barometz, and Ligusticum striatum are pulverized into fine powder, sieved, and decocted with natural copper and water for 2 hours. Then, Trachelospermum jasminoides, Lycopodium clavatum, Lycopus lucidus, Mistletoe, and Spatholobus suberectus are added and decocted twice, the first time for 3 hours and the second time for 2 hours. The decoctions are combined, filtered, allowed to stand, and the supernatant is concentrated into a thick paste. The above powder, an appropriate amount of starch, and maltose are added, granulated, dried, and pressed into tablets to obtain the product.

[0004] Because the raw material powder of Shujin Huoxue Tablets contains a large amount of fiber, the elasticity of the particles is enhanced, which counteracts the effect of the adhesive. During the tableting process, it is difficult to bond tightly, which can easily lead to loose tablets. The active ingredients cannot be released evenly, affecting product quality. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a method for preparing muscle-relaxing and blood-activating tablets, thereby solving the technical problem of existing tablets that easily lead to muscle relaxation.

[0006] This invention provides a method for preparing muscle-relaxing and blood-activating tablets, comprising the following steps:

[0007] a. Grind safflower, vinegar-processed Cyperus rotundus, scalded Cibotium barometz, and Perilla frutescens into a fine powder using ultra-micro powder;

[0008] b. Calcined natural copper was boiled with water, and Trachelospermum jasminoides, Lycopodium clavatum, Lycopodium clavatum, Mistletoe, and Spatholobus suberectus were added and boiled. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract, dried, pulverized, and sieved to obtain dry extract powder.

[0009] c. Place the fine powder and dry extract powder in the fluidization chamber of a fluidized bed, spray the binder solution from the top for fluidized bed granulation, drying, and tableting to obtain the final product.

[0010] Furthermore, in step a, the particle size of the fine powder is 10–50 μm. Through research, the inventors have ultra-finely pulverized safflower, vinegar-processed Cyperus rotundus, scalded Cibotium barometz, and Perilla frutescens into fine powder, controlling the particle size to 10–50 μm. This process produces more uniform and delicate particles during granulation, improving particle flowability and compressibility, reducing issues with filling and flowability between powder particles during tableting, and minimizing the occurrence of loose tablets.

[0011] Further, in step b, calcined natural copper is decocted with water for 2 hours; then Trachelospermum jasminoides, Lycopodium clavatum, Lycopus lucidus, Viscum album, and Spatholobus suberectus are added and decocted twice, the first time for 3 hours and the second time for 2 hours. The decoctions are combined, filtered, allowed to stand, and the supernatant is concentrated into an extract with a relative density of 1.25 to 1.35 at 70°C.

[0012] Further, the extract is dried, pulverized, and passed through an 80-120 mesh sieve.

[0013] The extract is dried and pulverized through an 80-120 mesh sieve and then mixed with the fine powder with a particle size of 10-50 μm for fluidized bed granulation. This process can form particles with different particle size distributions, better fill the gaps between particles, improve particle density, and enhance particle stability.

[0014] Further, in step c, the adhesive solution is prepared by adding water to povidone and hydroxypropyl methylcellulose to form a solution with a concentration of 10-20%.

[0015] Furthermore, the total amount of povidone and hydroxypropyl methylcellulose used is 3 to 8% of the total mass of the fine powder and dry extract powder.

[0016] Furthermore, the amount of povidone used is twice the mass of hydroxypropyl methylcellulose.

[0017] To address the issue of loose granules, the inventors discovered through research that povidone and hydroxypropyl methylcellulose (HPP) have a synergistic effect during granulation. Povidone provides adhesion between granules, while HPP improves granule flowability. By rationally adjusting the ratio of the two, with povidone used at twice the mass of HPP, a balance between granule adhesion and flowability can be achieved, effectively solving the loose granule problem.

[0018] Further, in step c, the fluidized bed granulation process controls the inlet air temperature to be 60–90°C, the inlet air humidity to be 30–50%, and the inlet air volume to be 1000–3000 m³ / h. 3 / h, spray pressure 1~3 bar, spray rate 10~50 mL / min, material temperature 40~70℃, adhesive solution spraying speed 30~80 g / min.

[0019] To address the issue of loose granules, the inventors employed fluidized bed granulation. Through extensive experimentation, they controlled the inlet air temperature during the fluidized bed granulation process to 60–90°C. This ensures rapid solvent evaporation while preventing the material surface from drying too quickly and forming a hard shell, thus contributing to the formation of uniform granules. Controlling the inlet air humidity to 30–50% ensures uniform wetting of the material during spraying, while preventing sticking due to excessive humidity during drying, further contributing to uniform granule formation. The inlet air volume was controlled to 1000–3000 m³ / h.3 A spray rate of 1-3 bar ensures thorough fluidization of the material within the fluidized bed, facilitating complete mixing and contact between particles. Maintaining a spray pressure of 1-3 bar ensures effective atomization of the binder solution, forming fine droplets that are evenly sprayed onto the material surface. A spray rate of 10-50 mL / min ensures uniform application of the binder solution, preventing over-wetting and promoting uniform particle formation. A material temperature of 40-70°C ensures uniform drying during the drying process, preventing localized overheating that could lead to surface hardening or internal solvent residue, further contributing to uniform particle formation. A binder solution injection rate of 30-80 g / min ensures uniform fluidization within the fluidized bed, reducing material accumulation and further improving production efficiency. By rationally controlling these process parameters, uniform fluidization, wetting, and drying of the material during fluidized bed granulation can be ensured, ultimately resulting in uniform and stable particles.

[0020] Furthermore, the temperature for fluidized bed drying is 60–90°C.

[0021] Furthermore, the rotation speed of the tablet press is controlled to be 18–40 r / min.

[0022] The beneficial effects of this invention are:

[0023] This invention uses ultrafine pulverization of safflower, vinegar-processed Cyperus rotundus, scalded Cibotium barometz, and Periploca sepium to form fine powder with a particle size of 10-50 μm. This allows for the formation of more uniform and delicate particles during granulation, improving particle flowability and compressibility. It reduces the problems of poor filling and flowability between powder particles during tableting, thus minimizing the occurrence of loose tablets. Simultaneously, povidone and hydroxypropyl methylcellulose are used as binders, with povidone used at twice the mass of hydroxypropyl methylcellulose. This synergistic effect balances the binding force and flowability of the particles, effectively solving the problem of loose tablets. Combined with fluidized bed granulation technology, strict control of process parameters during granulation ensures rapid solvent evaporation and uniform wetting and drying of the materials, further ensuring the uniformity and stability of the particles. Tablets prepared using this method have regular shapes, neat edges, and no missing corners or cracks. The tablet surface is smooth, without a grainy or rough feel, and the color is uniform without spots. The tablets have moderate hardness and toughness, without any looseness, and the overall structure is compact, without any breakage, peeling, cracks, or scratches. The friability is 0.1%. The disintegration time test shows that they can completely disintegrate within 11 minutes, and the content test results all meet the requirements. Detailed Implementation

[0024] The present invention will be further described in detail below through specific embodiments. All drugs and reagents involved in the specific embodiments are commercially available.

[0025] Example 1

[0026] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0027] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0028] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose are mixed with water at a mass ratio of 2:1 to prepare a 15% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used is 5% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 70℃, the inlet air humidity at 40%, and the inlet air volume at 2000 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 30 mL / min, material temperature 50℃, adhesive solution spraying speed 50 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0029] Example 2

[0030] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 50μm.

[0031] 13g of calcined natural copper was decocted in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and decocted twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.35 at 70℃. The extract was dried, pulverized, and passed through a 120-mesh sieve to obtain dry extract powder.

[0032] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose are mixed with water at a mass ratio of 2:1 to prepare a 20% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used is 8% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 90℃, the inlet air humidity at 50%, and the inlet air volume at 3000 m³ / h. 3 The following parameters were used: spray pressure 3 bar, spray rate 50 mL / min, material temperature 70℃, adhesive solution spraying speed 80 g / min, fluidized bed drying temperature 90℃, tableting speed 40 r / min, to produce 1000 tablets.

[0033] Example 3

[0034] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 10μm.

[0035] 13g of calcined natural copper was decocted in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and decocted twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.25 at 70℃. The extract was dried, pulverized, and passed through an 80-mesh sieve to obtain dry extract powder.

[0036] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose are mixed with water at a mass ratio of 2:1 to prepare a 10% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used is 3% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 60℃, the inlet air humidity at 30%, and the inlet air volume at 1000 m³ / h. 3 The following parameters were used: spray pressure 1 bar, spray rate 10 mL / min, material temperature 40℃, adhesive solution spraying speed 30 g / min, fluidized bed drying temperature 60℃, and tableting speed 18 r / min to produce 1000 tablets.

[0037] Example 4

[0038] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 40μm.

[0039] 13g of calcined natural copper was decocted in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and decocted twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.28 at 70℃. The extract was dried, pulverized, and passed through a 110-mesh sieve to obtain a dry extract powder.

[0040] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose are mixed with water at a mass ratio of 2:1 to prepare a 17% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used is 4% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 75℃, the inlet air humidity at 35%, and the inlet air volume at 2200 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 35 mL / min, material temperature 55℃, adhesive solution injection speed 60 g / min, fluidized bed drying temperature 80℃, tableting speed 35 r / min, to produce 1000 tablets.

[0041] Comparative Example 1

[0042] Safflower 80g, prepared Cyperus rotundus 300g, prepared Cibotium barometz 400g, Periploca sepium bark 200g, Trachelospermum jasminoides 300g, Lycopodium clavatum 300g, Lycopodium clavatum leaf 300g, Mistletoe 400g, Spatholobus suberectus 300g, calcined natural copper 50g. First, grind safflower, Cyperus rotundus, Cibotium barometz, and Periploca sepium barometz into a fine powder, sift, and decoct the natural copper in water for 2 hours. Then add Trachelospermum jasminoides, Lycopodium clavatum, Lycopodium clavatum leaf, Mistletoe clavatum, and Spatholobus suberectus and decoct twice, the first time for 3 hours and the second time for 2 hours. Combine the decoctions, filter, and let the supernatant concentrate into a thick paste. Add 980g of the above powder, 49g of starch, and 147g of maltose to form granules, dry, and press into 3818 tablets.

[0043] Comparative Example 2

[0044] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca spp. are ground into fine powder and passed through an 80-mesh sieve.

[0045] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0046] The above-mentioned fine powder and dry extract powder were placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose were mixed with water at a mass ratio of 2:1 to prepare a 15% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used was 5% of the total mass of the fine powder and dry extract powder.

[0047] The top-sprayed adhesive solution is granulated in a fluidized bed, with the inlet air temperature controlled at 70℃, inlet air humidity at 40%, and inlet air volume at 2000 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 30 mL / min, material temperature 50℃, adhesive solution spraying speed 50 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0048] Comparative Example 3

[0049] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0050] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0051] The above-mentioned fine powder and dry extract powder were placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose were mixed with water at a mass ratio of 2:1 to prepare a 15% binder solution. The total amount of povidone and hydroxypropyl methylcellulose was 5% of the total mass of the fine powder and dry extract powder. The binder solution was sprayed from the top for fluidized bed granulation. The inlet air temperature was controlled at 50℃, the inlet air humidity at 25%, and the inlet air volume at 800 m³ / h. 3 The following parameters were used: spray pressure 0.7 bar, spray rate 7 mL / min, material temperature 35℃, adhesive solution injection speed 20 g / min, fluidized bed drying temperature 75℃, and tableting speed 30 r / min to produce 1000 tablets.

[0052] Comparative Example 4

[0053] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0054] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0055] The above-mentioned fine powder and dry extract powder were placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose were mixed with water at a mass ratio of 2:1 to prepare a 15% binder solution. The total amount of povidone and hydroxypropyl methylcellulose was 5% of the total mass of the fine powder and dry extract powder. The binder solution was sprayed from the top for fluidized bed granulation. The inlet air temperature was controlled at 100℃, the inlet air humidity at 60%, and the inlet air volume at 3500 m³ / h. 3 The following parameters were used: spray pressure 4 bar, spray rate 60 mL / min, material temperature 75℃, adhesive solution spraying speed 90 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0056] Comparative Example 5

[0057] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0058] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0059] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone is mixed with water to prepare a 15% binder solution. The amount of povidone used is 5% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 70℃, the inlet air humidity at 40%, and the inlet air volume at 2000 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 30 mL / min, material temperature 50℃, adhesive solution spraying speed 50 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0060] Comparative Example 6

[0061] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0062] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0063] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Hydroxypropyl methylcellulose is mixed with water to prepare a 15% binder solution. The amount of hydroxypropyl methylcellulose used is 5% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 70°C, the inlet air humidity at 40%, and the inlet air volume at 2000 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 30 mL / min, material temperature 50℃, adhesive solution spraying speed 50 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0064] Comparative Example 7

[0065] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0066] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0067] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose are mixed with water at a mass ratio of 1:1 to prepare a 15% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used is 5% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 70℃, the inlet air humidity at 40%, and the inlet air volume at 2000 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 30 mL / min, material temperature 50℃, adhesive solution spraying speed 50 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0068] Comparative Example 8

[0069] According to the prescription, 21g of safflower, 79g of vinegar-processed Cyperus rotundus, 105g of scalded Cibotium barometz and 52g of Periploca sepium were ultra-finely pulverized into fine powder with a particle size of 30μm.

[0070] 13g of calcined natural copper was boiled in water for 2 hours. Then, 79g of Trachelospermum jasminoides, 79g of Lycopodium clavatum, 79g of Lycopodium clavatum, 105g of Loranthus parasiticus, and 79g of Spatholobus suberectus were added and boiled twice, once for 3 hours and once for 2 hours. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract with a relative density of 1.30 at 70℃. The extract was dried, pulverized, and passed through a 100-mesh sieve to obtain dry extract powder.

[0071] The fine powder and dry extract powder are placed in the fluidization chamber of a fluidized bed. Povidone and hydroxypropyl methylcellulose are mixed with water at a mass ratio of 3:1 to prepare a 15% binder solution. The total amount of povidone and hydroxypropyl methylcellulose used is 5% of the total mass of the fine powder and dry extract powder. The binder solution is sprayed from the top for fluidized bed granulation. The inlet air temperature is controlled at 70℃, the inlet air humidity at 40%, and the inlet air volume at 2000 m³ / h. 3 The following parameters were used: spray pressure 2 bar, spray rate 30 mL / min, material temperature 50℃, adhesive solution spraying speed 50 g / min, fluidized bed drying temperature 75℃, tableting speed 30 r / min, to produce 1000 tablets.

[0072] Verification Experiment Example

[0073] 1. See Table 1 for appearance details.

[0074] Table 1 Appearance Condition

[0075]

[0076]

[0077] 2. The fragility, disintegration time, and content of the muscle-relaxing and blood-activating tablets prepared in Examples 1-4 and Comparative Examples 1-8 were tested. See Table 2.

[0078] Table 2 Test Results

[0079] Friability / % Disintegration timeout / min Each tablet contains senna bark, calculated as 4-methoxysalicylaldehyde per (μg / tablet). Example 1 0.1 9 148 Example 2 0.1 11 148 Example 3 0.1 10 148 Example 4 0.1 10 148 Comparative Example 1 3.2 21 140 Comparative Example 2 1.2 17 142 Comparative Example 3 1.4 19 143 Comparative Example 4 2.5 30 141 Comparative Example 5 3.1 18 141 Comparative Example 6 3.0 19 140 Comparative Example 7 2.5 16 142 Comparative Example 8 3.3 25 139

[0080] In summary, the tablets prepared using the method of this invention have regular shapes, neat edges, and no missing corners or cracks. The tablet surface is smooth, without any grainy or rough texture, and the color is uniform without any spots. The tablets have moderate hardness, good toughness, and are not loose. The overall structure is compact, without breakage, peeling, cracks, or scratches. The friability is 0.1%. The disintegration time test shows that all tablets can completely disintegrate within 11 minutes, and the content test results all meet the requirements.

Claims

1. A method for preparing muscle-relaxing and blood-activating tablets, characterized in that: Includes the following steps: a. Grind safflower, vinegar-processed Cyperus rotundus, scalded Cibotium barometz, and Perilla frutescens into a fine powder using ultra-micro powder; b. Calcined natural copper was boiled with water, and Trachelospermum jasminoides, Lycopodium clavatum, Lycopodium clavatum, Mistletoe, and Spatholobus suberectus were added and boiled. The decoctions were combined, filtered, and allowed to stand. The supernatant was concentrated into an extract, dried, pulverized, and sieved to obtain dry extract powder. c. Place the fine powder and dry extract powder in the fluidization chamber of a fluidized bed, spray the binder solution from the top for fluidized bed granulation, drying, and tableting to obtain the final product.

2. The preparation method according to claim 1, characterized in that: In step a, the particle size of the fine powder is 10–50 μm.

3. The preparation method according to claim 1 or 2, characterized in that: In step b, calcined natural copper is decocted with water for 2 hours; then Trachelospermum jasminoides, Lycopodium clavatum, Lycopodium clavatum, Mistletoe, and Spatholobus suberectus are added and decocted twice, the first time for 3 hours and the second time for 2 hours. The decoctions are combined, filtered, allowed to stand, and the supernatant is concentrated into an extract with a relative density of 1.25 to 1.35 at 70°C.

4. The preparation method according to claim 1, characterized in that: In step b, the extract is dried, pulverized, and passed through an 80-120 mesh sieve.

5. The preparation method according to claim 1, characterized in that: In step c, the adhesive solution is prepared by adding water to povidone and hydroxypropyl methylcellulose to form a solution with a concentration of 10-20%.

6. The preparation method according to claim 5, characterized in that: In step c, the total amount of povidone and hydroxypropyl methylcellulose is 3 to 8% of the total mass of the fine powder and dry extract powder.

7. The preparation method according to claim 5, characterized in that: In step c, the amount of povidone used is twice the mass of hydroxypropyl methylcellulose.

8. The preparation method according to claim 1, characterized in that: In step c, the fluidized bed granulation process controls the inlet air temperature to be 60–90°C, the inlet air humidity to be 30–50%, and the inlet air volume to be 1000–3000 m³ / h. 3 / h, spray pressure 1~3 bar, spray rate 10~50 mL / min, material temperature 40~70℃, adhesive solution spraying speed 30~80 g / min.

9. The preparation method according to claim 1, characterized in that: In step c, the temperature of the fluidized bed drying is 60–90°C.

10. The preparation method according to claim 1, characterized in that: In step c, the rotation speed of the tablet press is controlled to be 18-40 r / min.

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