Starch-based capsule material and preparation method thereof
By modifying the preparation method of starch-based capsule materials, and combining plasticizers such as glycerol, epoxidized soybean oil and galactitol, as well as adjusting the proportion of enzymes, the problem of poor toughness of starch-based capsules was solved, and high toughness and rapid drug release effect of the capsules were achieved.
Patent Information
- Application Number
- CN202511451678.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-11
- Publication Date
- 2025-12-12
AI Technical Summary
Existing starch-based capsules have poor toughness and mechanical properties, making it difficult to meet the requirements of drug carriers.
Starch-based capsules were prepared by combining modified starch, gelling agents, and plasticizers through gelatinization, degradation, and dipping methods. Glycerin, epoxidized soybean oil, and galactitol were used as plasticizers, and the ratio of pullulanase, glucoamylase, and β-amylase was adjusted to improve the toughness and mechanical strength of the capsules.
The prepared starch-based capsules have good toughness, are not easily broken, and release their contents quickly, meeting the requirements for drug carriers.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of medical adjuvant, in particular to a starch-based capsule material and a preparation method thereof. BACKGROUND
[0002] Capsules are common drug and functional ingredient carriers and are widely used in the field of preparation. According to the structure of the capsule, it is generally divided into hard capsules and soft capsules, and the hard capsule is also called "hollow capsule". The main raw material for producing hard capsules at home and abroad is gelatin, which is mainly derived from animal skin, bone, tendon and other tissues. Gelatin needs to go through processes such as deslagging, disinfection, cooking and dehydration, and finally forms an animal protein colloid, which has the characteristics of high viscosity, high freezing force and good film toughness and is used as a capsule shell material. However, the gelatin capsule itself has many defects, for example, the protein molecules in the gelatin are easy to crosslink with reducing sugar compounds and vitamin C and other drug ingredients, which affects the disintegration of the capsule and the stability of the drug; the water retention of the capsule is poor, and the toughness decreases when stored in a dry environment for a long time, becoming brittle, resulting in low capsule strength and easy breakage; and due to religious beliefs, animal-derived gelatin capsules are not accepted by people such as vegetarians. However, plant capsules have become an excellent alternative due to their natural source and lack of animal-derived ingredients. Starch-based capsules have attracted the attention of researchers due to their safety, non-toxicity and wide raw material sources. However, starch-based capsules also have problems such as poor mechanical properties, poor toughness, and viscosity or hardness not meeting the requirements of producing capsules, which limit their further development. Therefore, overcoming the above problems is crucial for the further development of starch-based capsules. SUMMARY
[0003] The present application provides a starch-based capsule material and a preparation method thereof, which solves the problem of poor toughness of starch-based capsules in the related art.
[0004] The technical scheme of the present application is as follows: The present application provides a starch-based capsule material, which comprises the following components by weight: modified starch 60-80 parts, gelling agent 1.5-3.5 parts, plasticizer 3-6 parts, and water 150-200 parts. The plasticizer comprises glycerol, epoxy soybean oil and galactitol in a mass ratio of 1:2:0.2-1.2.
[0005] As a further technical scheme, the mass ratio of glycerol, epoxy soybean oil and galactitol is 1:2:0.4-0.8.
[0006] As a further technical scheme, the modified starch comprises one or more of oxidized starch, acetic ester starch and hydroxypropyl starch.
[0007] As a further technical scheme, the gelling agent comprises one or more of carrageenan, xanthan gum and guar gum.
[0008] The application further provides a preparation method of the starch-based capsule material. S1, mixing modified starch, water and a gelling agent, gelatinizing, degrading, deactivating enzymes to obtain a mixed glue solution; S2, adding a plasticizer to the mixed glue solution to obtain a starch glue solution; S3, film forming by dip coating to obtain the starch-based capsule material.
[0009] As a further technical solution, the gelatinization temperature is 80-100 DEG C, and the time is 1-2h.
[0010] As a further technical solution, enzymes are added, and the enzymes include pullulanase, glucoamylase and beta-amylase with a mass ratio of 1:1.2:1-3.
[0011] As a further technical solution, the mass ratio of the pullulanase, glucoamylase and beta-amylase is 1:1.2:1.5-2.5.
[0012] In the application, when the mass ratio of the pullulanase, glucoamylase and beta-amylase is further regulated to 1:1.2:1.5-2.5, the disintegration time of the capsule is shorter, which is helpful for the release of the content.
[0013] As a further technical solution, the mass of the enzymes is 0.1%-0.18% of the mass of the modified starch.
[0014] As a further technical solution, the deactivation temperature of the enzymes is 80-85 DEG C, and the time is 8-10min.
[0015] The working principle and beneficial effects of the application are as follows: In the application, glycerol, epoxy soybean oil and galactitol are used to prepare the starch-based capsule, and the toughness of the prepared starch-based capsule is better, the capsule is not easy to break, and the release speed of the content is faster; glycerol can improve the flexibility and processability of the capsule through interaction with starch; epoxy soybean oil is used to improve the mechanical strength of the capsule, and galactitol is used in combination with glycerol and epoxy soybean oil, which can effectively regulate the aggregation state of starch, reduce the hygroscopicity and retrogradation tendency of the capsule, and finally improve the toughness of the capsule. DETAILED DESCRIPTION
[0016] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the embodiments of the application. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the application.
[0017] In the following examples and comparative examples, Oxidized starch: model 201-770-2, manufacturer Shandong Aicai Biological Technology Co., Ltd. Acetate starch: model 618-556-3, manufacturer Hebei Runbu Biological Technology Co., Ltd. Hydroxypropyl starch: model 225-027-7, manufacturer Henan Qinao Food Ingredients Co., Ltd.
[0018] Example 1 A starch-based capsule material, comprising the following components by weight: 60 parts of oxidized starch, 1.5 parts of carrageenan, 6 parts of plasticizer, 150 parts of water; The plasticizer comprises glycerol, epoxy soybean oil and galactitol in a mass ratio of 1:2:0.2; A preparation method of a starch-based capsule material, comprising the following steps: Mixing oxidized starch, water and carrageenan, gelatinizing at 80°C for 1h, degrading using pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:1, adding the amount of composite enzyme is 0.1% of the mass of oxidized starch, deactivating the enzyme at 80°C for 10min, to obtain a mixed glue solution; Adding a plasticizer to the mixed glue solution to obtain a starch glue solution; Dipping a template for preparing capsules into the starch glue solution to dip glue and form a film, to obtain a starch-based capsule material.
[0019] Example 2 A starch-based capsule material, comprising the following components by weight: 80 parts of acetate starch, 3.5 parts of xanthan gum, 3 parts of plasticizer, 200 parts of water; The plasticizer comprises glycerol, epoxy soybean oil and galactitol in a mass ratio of 1:2:1.2; A preparation method of a starch-based capsule material, comprising the following steps: Mixing acetate starch, water and xanthan gum, gelatinizing at 100°C for 2h, degrading using pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:1, adding the amount of composite enzyme is 0.18% of the mass of oxidized starch, deactivating the enzyme at 85°C for 8min, to obtain a mixed glue solution; Adding a plasticizer to the mixed glue solution to obtain a starch glue solution; Dipping a template for preparing capsules into the starch glue solution to dip glue and form a film, to obtain a starch-based capsule material.
[0020] Example 3 A starch-based capsule material, comprising the following components by weight: 25 parts of acetate starch, 40 parts of hydroxypropyl starch, 1 part of xanthan gum, 2 parts of guar gum, 5 parts of plasticizer, 180 parts of water; The plasticizer comprises glycerol, epoxidized soybean oil and galactitol in a mass ratio of 1:2:1.0; A preparation method of a starch-based capsule material, comprising the following steps: The acetate starch, the hydroxylated starch, water, xanthan gum and guar gum are mixed, pasted at 90 DEG C for 1.5 h, degraded by using pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:1, the amount of the added compound enzyme is 0.13% of the mass of the acetate starch and the hydroxylated starch, and the enzyme is inactivated at 83 DEG C for 9 min, so as to obtain a mixed glue solution; The plasticizer is added into the mixed glue solution, so as to obtain a starch glue solution; A template for preparing capsules is immersed into the starch glue solution, and a film is prepared by dipping glue, so as to obtain the starch-based capsule material.
[0021] Example 4 The difference between the present example and example 3 is that the plasticizer comprises glycerol, epoxidized soybean oil and galactitol in a mass ratio of 1:2:0.8.
[0022] Example 5 The difference between the present example and example 3 is that the plasticizer comprises glycerol, epoxidized soybean oil and galactitol in a mass ratio of 1:2:0.4.
[0023] Example 6 The difference between the present example and example 4 is that the plasticizer comprises glycerol, epoxidized soybean oil and galactitol in a mass ratio of 1:2:0.2.
[0024] Example 7 The difference between the present example and example 4 is that pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:3 are used for degradation.
[0025] Example 8 The difference between the present example and example 4 is that pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:2.5 are used for degradation.
[0026] Example 9 The difference between the present example and example 4 is that pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:1.5 are used for degradation.
[0027] Comparative Example 1 The difference between the present comparative example and example 3 is that the plasticizer comprises glycerol and epoxidized soybean oil in a mass ratio of 1:2.
[0028] Comparative Example 2 The difference between the present comparative example and example 3 is that the plasticizer comprises glycerol and galactitol in a mass ratio of 1:1.0.
[0029] Comparative Example 3 The only difference between this comparative example and Example 3 is that the plasticizer comprises epoxy soybean oil and galactitol in a mass ratio of 2:1.0.
[0030] The capsules prepared in Examples 1-9 and Comparative Examples 1-3 were tested according to the following method: According to the standards of the Chinese Pharmacopoeia (2015 edition), the tightness, friability and disintegration time of the prepared capsule products were tested; The test results are shown in Table 1: Table 1 Performance test results of capsules prepared in Examples 1-9 and Comparative Examples 1-3
[0031] 1. Compared with Comparative Examples 1-3, the capsules prepared in Examples 1-8 have low friability and short disintegration time, indicating that when glycerol, epoxy soybean oil and galactitol are used in combination, the prepared capsules have good toughness, are not easy to break, and the content is released quickly.
[0032] 2. Compared with Examples 3-6, the capsules prepared in Examples 4-5 have low friability and short disintegration time, indicating that further limiting the mass ratio of glycerol, epoxy soybean oil and galactitol to 1:2:0.4-0.8, the prepared capsules have good toughness, are not easy to break, and the content is released quickly.
[0033] 3. Compared with Example 4 and Examples 7-9, the capsules prepared in Examples 8-9 have short disintegration time, indicating that further limiting the mass ratio of pullulanase, glucoamylase and beta-amylase to 1:2:1.5-2.5, the prepared capsules have faster content release speed.
[0034] The above is only a preferred embodiment of the present application and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.
Claims
1. A starch-based encapsulating material, characterized in that, The components include the following weight parts: modified starch 60-80 parts, gelling agent 1.5-3.5 parts, plasticizer 3-6 parts, water 150-200 parts; The plasticizer includes glycerol, epoxy soybean oil and galactitol in a mass ratio of 1:2:0.2-1.
2.
2. A starch-based encapsulate material according to claim 1, characterized in that, The mass ratio of the glycerol, epoxy soybean oil and galactitol is 1:2:0.4-0.
8.
3. A starch-based encapsulate material according to claim 1, wherein, The modified starch includes one or more of oxidized starch, acetate starch and hydroxypropyl starch.
4. A starch-based encapsulate material according to claim 1, wherein, The gelling agent includes one or more of carrageenan, xanthan gum and guar gum.
5. A process for the preparation of a starch-based encapsulating material according to any one of claims 1 to 4, characterized in that The method includes the following steps: S1, mixing modified starch, water and gelling agent, gelatinizing, degrading, enzyme inactivating to obtain mixed glue liquid; S2, adding plasticizer to the mixed glue liquid to obtain starch glue liquid; S3, adopting dip glue method to prepare film to obtain starch-based capsule material.
6. A process for the preparation of a starch-based encapsulating material according to claim 5, characterized in that, The gelatinizing temperature is 80-100℃ and the time is 1-2h.
7. A process for the preparation of a starch-based encapsulating material according to claim 5, characterized in that, The enzyme is added during the degrading, and the enzyme includes pullulanase, glucoamylase and beta-amylase in a mass ratio of 1:1.2:1-3.
8. A process for the preparation of a starch-based encapsulating material according to claim 7, characterized in that, The mass ratio of the pullulanase, glucoamylase and beta-amylase is 1:1.2:1.5-2.
5.
9. A process for the preparation of a starch-based encapsulating material according to claim 7, characterized in that, The mass of the enzyme is 0.1%-0.18% of the mass of the modified starch.
10. A process for the preparation of a starch-based encapsulating material according to claim 5, characterized in that, The enzyme inactivating temperature is 80-85℃ and the time is 8-10min.