Pine needle-like microneedle patch

Abstract

The invention relates to the field of microneedle patches, and discloses a pine needle-imitated microneedle patch, which comprises an adhesive sheet for supporting a whole device, the upper surface of the adhesive sheet is coated with an adhesive and can assist the whole device to adhere to the body surface of a patient, the lower surface of the adhesive sheet is a smooth surface, and the adhesive sheet is provided with a plurality of needle needles. The upper end of the adhesive sheet is fixedly connected with a plurality of groups of main needle bodies; a side needle leaf is arranged on the outer wall of the main needle body, the side needle leaf comprises an upper needle body, a secondary needle body and a lower needle body, the upper needle body, the secondary needle body and the lower needle body are sequentially arranged on the outer wall of the main needle body from top to bottom, the upper needle body, the secondary needle body and the lower needle body are inclined, and the sizes of the upper needle body, the secondary needle body and the lower needle body are gradually reduced from top to bottom. According to the invention, by adopting a pine needle imitating design and arranging the side needle leaves on the outer wall of the main needle body, the surface area of the whole device can be increased, so that the drug loading capacity of the whole device can be directly increased, and meanwhile, through the cooperation of the hydrophobic coating and the hydrophilic coating, the controllable dosing can be realized.

Description

Technical Field

[0001] This invention relates to the field of microneedle patches, and more particularly to a pine needle-inspired microneedle patch. Background Technology

[0002] Microneedle patches are special patches that use microneedles to penetrate the outermost layer of the skin, the stratum corneum, to form controllable tiny channels in the epidermis and dermis. These micro-damages do not damage deep tissues or touch nerves, and therefore do not produce pain, thus achieving painless treatment. In recent years, microneedle patch technology has developed rapidly.

[0003] In existing technologies, the microneedles in common microneedle patches are mainly cone-shaped with smooth outer walls and no grooves. Therefore, the amount of drug solution they can carry is very limited during use. Furthermore, since the needle tip enters first and the needle tail enters later during puncture, more drug comes into contact with the outer tissue and less with the inner tissue. The release of drug solution is uncontrollable during use. To address these issues, a pine needle-inspired microneedle patch is proposed. Summary of the Invention

[0004] To overcome the above shortcomings, the present invention provides a pine needle-like microneedle patch, which aims to improve the problems of "low drug storage capacity and uncontrollable drug release in existing microneedle patches" during use.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a pine needle-like microneedle patch, characterized in that it comprises:

[0006] An adhesive sheet is used to support the overall device. The upper surface of the adhesive sheet is coated with an adhesive to help the overall device adhere to the patient's body surface. The lower surface of the adhesive sheet is set as a smooth surface. The upper end of the adhesive sheet is fixedly connected to the main needle body, and there are multiple sets of them.

[0007] The outer wall of the main needle body is provided with side needle blades, each side needle blade comprising an upper needle body, a secondary needle body, and a lower needle body. The upper needle body, secondary needle body, and lower needle body are arranged sequentially from top to bottom on the outer wall of the main needle body. The upper needle body, secondary needle body, and lower needle body are all inclined and their size gradually decreases from top to bottom. The outer wall of the main needle body is provided with a liquid storage component. The outer wall of the main needle body near the upper part of the secondary needle body up to the top is coated with a hydrophobic coating, and the outer wall of the main needle body near the lower part of the secondary needle body up to the bottom is coated with a hydrophilic coating.

[0008] The liquid storage assembly includes a liquid guiding groove disposed on the outer wall of the adhesive sheet for storing the medicine liquid.

[0009] As a further description of the above technical solution:

[0010] The liquid storage assembly also includes blades, which are disposed on the outer wall of the adhesive sheet, and the upper end of the blades is connected to the adhesive sheet.

[0011] As a further description of the above technical solution:

[0012] The blade is generally inclined, and a liquid storage cavity is provided between the lower end of the blade and the outer wall of the adhesive sheet. The liquid storage cavity is connected to the liquid guiding groove.

[0013] As a further description of the above technical solution:

[0014] The upper end of the liquid guiding groove is flush with the lower end of the secondary needle body, and the lower end of the liquid guiding groove penetrates the lower surface of the adhesive sheet.

[0015] As a further description of the above technical solution:

[0016] The upper surface of the upper needle body, the secondary needle body, and the lower needle body are all provided with grooves.

[0017] As a further description of the above technical solution:

[0018] The cross-section of the liquid guiding channel is trapezoidal, and the liquid guiding channel and the side needles are arranged alternately.

[0019] As a further description of the above technical solution:

[0020] The upper end of the liquid guiding groove is flush with the lower surface of the upper needle body, and the lower end of the liquid guiding groove penetrates the lower surface of the adhesive sheet.

[0021] As a further description of the above technical solution:

[0022] The liquid guiding groove is trapezoidal, the side needle is disposed on the outer wall of the liquid guiding groove, and the upper needle body, secondary needle body and lower needle body are disposed on the outer wall of the liquid guiding groove from top to bottom.

[0023] As a further description of the above technical solution:

[0024] The upper needle body, secondary needle body, and lower needle body are interconnected through a liquid guide groove.

[0025] As a further description of the above technical solution:

[0026] The upper end of the liquid guiding groove is parallel to the upper surface of the upper needle body, and the lower end of the liquid guiding groove penetrates the lower surface of the adhesive sheet.

[0027] The present invention has the following beneficial effects:

[0028] 1. In this invention, by adopting a pine needle-like design and setting side needle blades on the outer wall of the main needle, the surface area of ​​the overall device can be increased, thus directly increasing the drug loading capacity of the overall device. At the same time, through the combination of hydrophobic and hydrophilic coatings, when the main needle is not fully inserted, water molecules can be isolated by the hydrophobic coating. When the main needle is fully inserted, water molecules can be guided to combine with the drug solution on the outer wall of the device by the hydrophilic coating, thus achieving controllable drug delivery.

[0029] 2. In this invention, by setting a side needle leaf, the main needle body can be guided by the side needle leaf during the process of guiding the main needle body into the user's body. This can prevent the main needle body from bending during the insertion process and increase the stability of puncture.

[0030] 3. In this invention, by setting up a liquid storage chamber, when the whole device is fully inserted during treatment, the user's skin will squeeze the blade to force it to adhere to the main needle body, thus forcing the liquid inside the liquid storage chamber to be discharged, which can further increase the single dose of the whole device.

[0031] 4. In this invention, by setting the side needle blades on the outer wall of the liquid guiding groove, the discharge of the liquid can be guided. The liquid in the liquid guiding groove can flow into the side needle blades along the grooves and, under the guidance of the side needle blades, evenly contact the user's tissue area, thus further improving the uniformity of drug administration. Attached Figure Description

[0032] Figure 1 This is a three-dimensional structural diagram of the overall device in this invention;

[0033] Figure 2 This is a three-dimensional structural diagram of the main needle body in this invention;

[0034] Figure 3 This is a bottom view of the three-dimensional structure of the main needle body in this invention;

[0035] Figure 4 This is a three-dimensional structural breakdown diagram of the side needle blade in this invention;

[0036] Figure 5 This is a bottom view of the three-dimensional structure of Embodiment 2 of the present invention;

[0037] Figure 6 This is a three-dimensional structural diagram of Embodiment 2 of the present invention;

[0038] Figure 7 This is a three-dimensional structural diagram of Embodiment 3 of the present invention;

[0039] Figure 8 This is a bottom view of the three-dimensional structure of Embodiment 3 of the present invention.

[0040] Legend:

[0041] 1. Adhesive sheet; 2. Main needle body; 3. Side needle blade; 31. Upper needle body; 32. Secondary needle body; 33. Lower needle body; 34. Groove; 4. Liquid storage assembly; 41. Blade; 42. Liquid guide groove; 43. Liquid storage chamber. Detailed Implementation

[0042] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0043] Example 1:

[0044] Reference Figure 1 - Figure 3 This invention provides an embodiment of a pine needle-like microneedle patch, comprising an adhesive sheet 1 for supporting the overall device. The adhesive sheet 1 can be made of a flexible material, allowing for better adhesion to the patient's skin during use. The upper surface of the adhesive sheet 1 is coated with an adhesive to help the overall device adhere to the patient's body surface. The lower surface of the adhesive sheet 1 is smooth, allowing the entire adhesive sheet 1 to be held and adhered to the drug delivery site during use. Multiple main needle bodies 2 are fixedly connected to the upper end of the adhesive sheet 1. The main needle bodies 2 are generally conical, providing good puncture and pressure resistance. The outer wall of the main needle body 2 is provided with side needle blades 3 for assisting drug delivery. The side needle blades 3 include an upper needle body 31, a secondary needle body 32, and a lower needle body 33. All three are flattened conical in shape and are arranged sequentially from top to bottom on the outer wall of the main needle body 2. The secondary needle body 32 and the lower needle body 33 are both inclined and their dimensions gradually decrease from top to bottom. The upper needle body 31, the secondary needle body 32, and the lower needle body 33 are the same type of components with the same structure but different dimensions. The outer wall of the main needle body 2 is provided with a liquid storage component 4 for storing the medicine. The outer wall of the main needle body 2 is coated with a hydrophobic coating from the top of the secondary needle body 32 to the top. The hydrophobic coating is a functional coating that can significantly reduce the affinity of the material surface for water. Water will form obvious droplets on its surface and is not easy to spread, thus preventing water molecules from contacting the medicine molecules. The outer wall of the main needle body 2 is coated with a hydrophilic coating from the bottom of the secondary needle body 32 to the bottom. The hydrophilic coating is a coating that can enhance the affinity of the material surface for water. Water can easily spread, wet, or even completely cover the surface on its surface, which can promote the fusion of water molecules with the medicine on the surface of the device. The liquid storage component 4 includes a liquid guiding groove 42, which is provided on the outer wall of the adhesive sheet 1 for storing the medicine.

[0045] Reference Figure 2 - Figure 4 The liquid storage assembly 4 also includes a blade 41 for squeezing the liquid. The blade 41 is disposed on the outer wall of the adhesive sheet 1. The upper end of the blade 41 is connected to the adhesive sheet 1. The blade 41 has elastic deformation capability and will undergo elastic deformation when squeezed. The blade 41 is generally set in an inclined shape. When the blade 41 is not squeezed, it will move away from the main needle body 2 under its own elastic force. A liquid storage cavity 43 is provided between the lower end of the blade 41 and the outer wall of the main needle body 2. When the whole device is immersed in the liquid, the liquid can enter the interior of the liquid storage cavity 43. The liquid storage cavity 43 is connected to the liquid guide groove 42. When the blade 41 is squeezed, the liquid inside the liquid storage cavity 43 will be forced out, and this part of the liquid will flow out along the liquid guide groove 42.

[0046] Reference Figure 2 - Figure 4 The upper end of the liquid guiding groove 42 is flush with the lower end of the secondary needle body 32. With this setting, the liquid guiding groove 42 will be completely covered by the skin-friendly coating. The lower end of the liquid guiding groove 42 penetrates the lower surface of the adhesive sheet 1. The upper surfaces of the upper needle body 31, secondary needle body 32, and lower needle body 33 are all provided with grooves 34 for guiding the medicine. The grooves 34 can increase the surface area of ​​the upper needle body 31, secondary needle body 32, and lower needle body 33 to a certain extent, and can increase the medicine carrying capacity of the upper needle body 31, secondary needle body 32, and lower needle body 33.

[0047] Example 2:

[0048] Reference Figure 3 , Figure 5 and Figure 6 The cross-section of the liquid guiding groove 42 is set as a trapezoid. This design reduces the contact area between water molecules and the liquid medicine, and ensures that more liquid medicine can be stored inside the liquid guiding groove 42. The liquid guiding groove 42 and the side needle 3 are staggered. This design ensures that when the liquid medicine inside the liquid guiding groove 42 needs to be discharged, it can only diffuse through contact with the liquid medicine. This reduces the diffusion rate of the liquid medicine and achieves slow release. The upper end of the liquid guiding groove 42 is flush with the lower surface of the upper needle body 31, and the lower end of the liquid guiding groove 42 penetrates the lower surface of the adhesive sheet 1. This design increases the contact area between the liquid medicine and water molecules, thereby achieving uniform drug delivery.

[0049] Example 3:

[0050] Reference Figure 3 , Figure 7 and Figure 8The liquid guiding groove 42 is trapezoidal, which increases the storage capacity of the liquid. The side needle 3 is located on the outer wall of the liquid guiding groove 42. The upper needle body 31, the secondary needle body 32, and the lower needle body 33 are arranged from top to bottom on the outer wall of the liquid guiding groove 42. With this arrangement, when the liquid inside the liquid guiding groove 42 needs to be discharged, the liquid can come into contact with water molecules through the upper needle body 31, the secondary needle body 32, and the lower needle body 33. The upper needle body 31, the secondary needle body 32, and the lower needle body 33 are interconnected through the liquid guiding groove 42. The upper needle body 31, the secondary needle body 32, and the lower needle body 33 can guide the liquid to be discharged quickly, realizing rapid drug administration. The upper end of the liquid guiding groove 42 is parallel to the upper surface of the upper needle body 31, and the lower end of the liquid guiding groove 42 penetrates the lower surface of the adhesive sheet 1. This arrangement ensures that the liquid inside the liquid guiding groove 42 can correctly contact the upper needle body 31, the secondary needle body 32, and the lower needle body 33.

[0051] Working principle: Before use, the entire device is immersed in the medication solution. The medication solution adheres to the outer wall of the main needle body 2 and the side needle leaf 3 and the groove 34 through surface adsorption. At the same time, the liquid storage chamber 43 draws in the medication solution through the liquid guide groove 42 to complete pre-storage. The inclined structure and gradually changing size design of the side needle leaf 3 provide guidance and support for puncture. When applying the patch, the adhesive patch 1 is fixed to the skin surface by the upper surface adhesive. The main needle body 2 punctures the skin under the guidance of the side needle leaf 3. The side needle leaf 3 effectively prevents the main needle body 2 from bending, ensuring stable puncture. Qualitatively, in the initial stage of puncture, before the main needle body 2 is fully inserted, the hydrophobic coating above the secondary needle body 32 isolates the skin tissue fluid, preventing the drug solution from contacting water molecules in advance, thus achieving precise control in the initial stage of drug administration. When the main needle body 2 is fully inserted, the hydrophilic coating below the secondary needle body 32 contacts the skin tissue fluid, promoting the spread of water molecules and their fusion with the drug solution on the surface of the side needle leaf 3 and the groove 34. At the same time, the skin squeezes the elastic leaf 41 to make it adhere to the main needle body 2, and the drug solution in the reservoir 43 is discharged through the guide groove 42 after being compressed.

[0052] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A pine needle-like microneedle patch, characterized in that, include: Adhesive sheet (1) is used to support the overall device. The upper surface of the adhesive sheet (1) is coated with adhesive to help the overall device adhere to the patient's body surface. The lower surface of the adhesive sheet (1) is set as a smooth surface. The upper end of the adhesive sheet (1) is fixedly connected to the main needle body (2) and there are multiple sets of them. The outer wall of the main needle body (2) is provided with side needle blades (3). The side needle blades (3) include an upper needle body (31), a secondary needle body (32), and a lower needle body (33). The upper needle body (31), the secondary needle body (32), and the lower needle body (33) are arranged sequentially from top to bottom on the outer wall of the main needle body (2). The upper needle body (31), the secondary needle body (32), and the lower needle body (33) are all set in an inclined shape and their size gradually decreases from top to bottom. The outer wall of the main needle body (2) is provided with a liquid storage component (4). The outer wall of the main needle body (2) is coated with a hydrophobic coating from the upper part of the secondary needle body (32) to the top end. The outer wall of the main needle body (2) is coated with a hydrophilic coating from the lower part of the secondary needle body (32) to the bottom end. The liquid storage assembly (4) includes a liquid guide groove (42), which is disposed on the outer wall of the adhesive sheet (1) and is used to store the liquid medicine.

2. The pine needle-like microneedle patch according to claim 1, characterized in that: The liquid storage assembly (4) also includes a blade (41), which is disposed on the outer wall of the adhesive sheet (1), and the upper end of the blade (41) is connected to the adhesive sheet (1).

3. The pine needle-like microneedle patch according to claim 2, characterized in that: The blade (41) is generally inclined, and a liquid storage cavity (43) is provided between the lower end of the blade (41) and the outer wall of the adhesive sheet (1). The liquid storage cavity (43) is connected to the liquid guide groove (42).

4. The pine needle-like microneedle patch according to claim 3, characterized in that: The upper end of the liquid guiding groove (42) is flush with the lower end of the secondary needle body (32), and the lower end of the liquid guiding groove (42) penetrates the lower surface of the adhesive sheet (1).

5. The pine needle-like microneedle patch according to claim 4, characterized in that: The upper surfaces of the upper needle body (31), the secondary needle body (32), and the lower needle body (33) are all provided with grooves (34).

6. The pine needle-like microneedle patch according to claim 1, characterized in that: The cross-section of the liquid guiding groove (42) is set as trapezoidal, and the liquid guiding groove (42) and the side needles (3) are arranged alternately.

7. The pine needle-like microneedle patch according to claim 6, characterized in that: The upper end of the liquid guiding groove (42) is flush with the lower surface of the upper needle body (31), and the lower end of the liquid guiding groove (42) penetrates the lower surface of the adhesive sheet (1).

8. The pine needle-like microneedle patch according to claim 1, characterized in that: The liquid guiding groove (42) is trapezoidal, the side needle (3) is disposed on the outer wall of the liquid guiding groove (42), and the upper needle body (31), the secondary needle body (32), and the lower needle body (33) are disposed on the outer wall of the liquid guiding groove (42) from top to bottom.

9. The pine needle-like microneedle patch according to claim 8, characterized in that: The upper needle body (31), the secondary needle body (32), and the lower needle body (33) are connected to each other through the liquid guide groove (42).

10. The pine needle-like microneedle patch according to claim 9, characterized in that: The upper end of the liquid guiding groove (42) is parallel to the upper surface of the upper needle body (31), and the lower end of the liquid guiding groove (42) penetrates the lower surface of the adhesive sheet (1).

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