Bacteriostatic and anti-hair loss composition as well as preparation method and application thereof
By combining Scutellaria baicalensis extract, white willow bark extract, wolfberry fruit extract, and yarrow extract, the shortcomings of existing shampoos in preventing hair loss are addressed, achieving a highly effective, safe, and low-cost antibacterial and anti-hair loss effect.
Patent Information
- Application Number
- CN202511378868.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-25
- Publication Date
- 2025-12-19
AI Technical Summary
Existing shampoos lack targeted efficacy in preventing hair loss, chemically synthesized antibacterial ingredients pose safety risks, while plant-derived antibacterial ingredients have insufficient antibacterial performance and are costly, making large-scale use difficult.
A compound of Scutellaria baicalensis extract, white willow bark extract, wolfberry fruit extract, and yarrow extract is used to prepare yarrow extract via enzyme-assisted extraction. The mixture is then added to shampoo to exert a synergistic antibacterial and anti-hair loss effect.
It achieves a mild, safe, and highly effective antibacterial and anti-hair loss effect. The plant-derived ingredients have a significant synergistic effect, excellent antibacterial properties, and a significant anti-hair loss effect, all at a low cost.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application belongs to the technical field of compositions, and in particular relates to a bacteriostatic anti-hair loss composition and a preparation method and application thereof. BACKGROUND
[0002] The functions of traditional shampoos are mostly concentrated on daily cleaning, such as removing sebum, dust, metabolic products and the like, and some products may also have the effects of smoothing and anti-dandruff, but in general, cleaning is still the dominant function, and there is a lack of targeted effects, and it is often difficult to deal with deeper hair health problems. With the development of society, the incidence of hair loss is increasing year by year, and more and more people are troubled by hair loss. In view of this phenomenon, many existing technologies make technical improvements around traditional shampoos, that is, bacteriostatic ingredients are added to traditional shampoos to improve the microecological environment of the scalp and achieve the effect of preventing hair loss. However, these existing bacteriostatic ingredients still have some limitations, which are not conducive to application. First, in order to pursue high bacteriostatic performance, many technical means choose chemically synthesized bacteriostatic ingredients, such as zinc pyrithione and ketoconazole, which can easily cause scalp sensitivity, stinging and other discomfort symptoms when used for a long time, and even have drug resistance problems. On the contrary, plant-derived bacteriostatic ingredients are more mild and safe, but their bacteriostatic performance is obviously inferior to that of the former, and a high amount of addition is required to achieve excellent results, which is high in cost and difficult to use on a large scale. SUMMARY
[0003] The present application belongs to the technical field of compositions, and in particular relates to a bacteriostatic anti-hair loss composition and a preparation method and application thereof.
[0004] The object of the present application can be achieved by the following technical solutions: In a first aspect, the present application provides a bacteriostatic anti-hair loss composition, which is made of the following raw materials: Scutellaria baicalensis Georgi extract, white willow bark extract, Lycium barbarum fruit extract and Urtica dioica extract.
[0005] As a preferred technical solution of the present application, the mass ratio of the Scutellaria baicalensis Georgi extract, the white willow bark extract, the Lycium barbarum fruit extract and the Urtica dioica extract is 1-1.3:3.5-5.2:4:7.
[0006] As a preferred technical solution of the present application, the Scutellaria baicalensis Georgi extract is obtained by market purchase; the white willow bark extract is obtained by market purchase; and the Lycium barbarum fruit extract is obtained by market purchase.
[0007] As a preferred technical solution of the present application, the Urtica dioica extract is prepared by an enzyme-assisted extraction method.
[0008] As a preferred technical scheme of the present application, the extract of Pteridium aquilinum is prepared by the following steps: Step S1, grinding Pteridium aquilinum to obtain Pteridium aquilinum powder; Step S2, adding the Pteridium aquilinum powder and a composite enzyme into an ethanol aqueous solution, heating under reflux, constant-temperature enzymolysis, enzyme inactivation, cooling, to obtain an extract; Step S3, centrifuging the extract, taking the supernatant, and spray drying, to complete the preparation.
[0009] Preferably, in step S1, the particle size of the Pteridium aquilinum powder is 120-200 μm.
[0010] Preferably, in step S2, the mass ratio of the Pteridium aquilinum powder, the composite enzyme, and the ethanol aqueous solution is 4.2-6.8:0.35-0.4:155.
[0011] Preferably, in step S2, the composite enzyme comprises hemicellulase and pectinase in a mass ratio of 1-1.4:1.2; the hemicellulase is commercially available; and the pectinase is commercially available.
[0012] Preferably, in step S2, the mass fraction of the ethanol aqueous solution is 5-8%.
[0013] Preferably, in step S2, the heating is heating to 48-54℃; and the heating speed is 2-3℃ / min.
[0014] Preferably, in step S2, the enzymolysis time is 30-45 min.
[0015] Preferably, in step S2, the enzyme inactivation is heat treatment at 90℃ for 8-14 min under reflux.
[0016] Preferably, in step S2, the cooling is cooling to 25-30℃; and the cooling speed is 2-3℃ / min.
[0017] Preferably, in step S3, the centrifugation speed is 8500-10000 rpm; and the centrifugation time is 10-14 min.
[0018] Preferably, in step S3, the inlet air temperature of the spray drying is 180-185℃; the exhaust air temperature of the spray drying is 85-90℃; and the pressure of the atomizer of the spray drying is 10 MPa.
[0019] In a second aspect, the present application provides a preparation method of a bacteriostatic and anti-hair loss composition, which comprises the following steps: Mixing the extract of Scutellaria baicalensis Georgi, the extract of white willow bark, the extract of Lycium fruit, and the extract of Pteridium aquilinum, to complete the preparation.
[0020] In a third aspect, the present application provides an application of the anti-bacterial and anti-hair loss composition in shampoo, which comprises the following steps: The anti-bacterial and anti-hair loss composition is added to the shampoo at 1.2-2.5% of the mass of the shampoo.
[0021] The present application has the following advantages: (1) The present application preferably uses four plant-derived ingredients to achieve excellent anti-bacterial performance, and the anti-bacterial and anti-hair loss effect is excellent after a small amount of the anti-bacterial and anti-hair loss composition is added to the shampoo, wherein the four plant-derived ingredients are Scutellaria baicalensis Georgi extract, white willow bark extract, Lycium barbarum fruit extract, and Yarrow extract; the Scutellaria baicalensis Georgi extract is derived from Chinese medicine Scutellaria baicalensis Georgi, and the main active ingredient has a broad-spectrum antibacterial effect, can inhibit the reproduction of common harmful bacteria on the scalp, reduce the inflammatory response of hair follicles, and achieve anti-bacterial and anti-hair loss; the white willow bark extract is rich in natural salicylic acid, has mild antibacterial and anti-inflammatory properties, can reduce the damage of inflammatory factors to hair follicles, and also has a certain cleaning effect on the accumulated keratin and oil on the scalp, can provide a good growth environment for hair, and promote the anti-bacterial and anti-hair loss effect; the Lycium barbarum fruit extract contains polysaccharides, flavonoids and other active ingredients, can directly act on the microbial community of the scalp, reduce the physiological activity of harmful bacteria, reduce the secretion of irritating and sensitive substances, and avoid hair loss; the Yarrow extract can interfere with the integrity of the cell membrane of bacteria and fungi to achieve the purpose of inhibiting bacteria, and also can protect the hair from oxidative damage through antioxidant effect, and plays a role in anti-hair loss from multiple aspects.
[0022] (2) The present application preferably uses enzyme-assisted extraction method to prepare the Yarrow extract with the highest content, realizes the effective dissolution of active ingredients through the combined enzymolysis of hemicellulase and pectinase, and uses low-concentration ethanol aqueous solution as the extraction solvent, so that the active ingredients can better play a role with other plant-derived ingredients and produce a good synergistic effect.
[0023] (3) The anti-bacterial and anti-hair loss composition of the present application is made of plant-derived ingredients, is mild and safe, has excellent anti-bacterial performance, and can achieve excellent anti-hair loss effect after being applied and added to the shampoo, and the anti-bacterial performance and the anti-hair loss effect are highly positively correlated. DETAILED DESCRIPTION
[0024] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.
[0025] The Scutellaria extract used in the embodiments and the comparative examples is purchased from Shanyang Lianfeng Biotechnology Co., Ltd., with a specification of 10:1; the white willow bark extract is purchased from Xi'an Jinxiufang Plant Technology Development Co., Ltd., with a specification of 10:1; the medlar fruit extract is purchased from Lanzhou Waterless Biotechnology Co., Ltd., with a specification of 10:1; the hemicellulase is purchased from Shanghai Yuanye Biotechnology Co., Ltd., with a number of S10045; the pectinase is purchased from Shanghai Yuanye Biotechnology Co., Ltd., with a number of S10007; the above will not be described in detail hereinafter.
[0026] Embodiment 1 A bacteriostatic and anti-hair loss composition is prepared from Scutellaria extract, white willow bark extract, medlar fruit extract and Yarrow extract; the mass ratio of the Scutellaria extract, the white willow bark extract, the medlar fruit extract and the Yarrow extract is 1:3.5:4:7; the Yarrow extract is prepared by enzyme-assisted extraction.
[0027] The Yarrow extract is prepared by the following steps: Step S1, grinding Yarrow to obtain Yarrow powder; the particle size of the Yarrow powder is 120 μm; Step S2, adding the Yarrow powder and a composite enzyme into an ethanol aqueous solution, heating under reflux, constant-temperature enzymolysis, enzyme inactivation, cooling to obtain an extract; the mass ratio of the Yarrow powder, the composite enzyme and the ethanol aqueous solution is 4.2:0.35:155; the composite enzyme comprises hemicellulase and pectinase with a mass ratio of 1:1.2; the mass fraction of the ethanol aqueous solution is 5%; the heating refers to heating to 48℃; the heating speed is 2℃ / min; the enzymolysis time is 30 min; the enzyme inactivation refers to heat treatment at 90℃ for 8 min under reflux; the cooling refers to cooling to 25℃; the cooling speed is 2℃ / min; Step S3, centrifuging the extract, taking the supernatant and spray drying to complete the preparation; the centrifugation speed is 8500 rpm; the centrifugation time is 10 min; the inlet air temperature of the spray drying is 180℃; the exhaust air temperature of the spray drying is 85℃; the pressure of the atomizer of the spray drying is 10 MPa.
[0028] A preparation method of a bacteriostatic and anti-hair loss composition, the preparation method comprising the following steps: Mixing Scutellaria extract, white willow bark extract, medlar fruit extract and Yarrow extract to complete the preparation.
[0029] Application of a bacteriostatic and anti-hair loss composition in shampoo, the application comprising the following steps: Adding the bacteriostatic and anti-hair loss composition to the shampoo at 1.2% of the mass of the shampoo.
[0030] Embodiment 2 A bacteriostatic and anti-hair loss composition is prepared from the following raw materials: Scutellaria baicalensis Georgi extract, white willow bark extract, Lycium fruit extract, and Urtica dioica extract; the mass ratio of the Scutellaria baicalensis Georgi extract, the white willow bark extract, the Lycium fruit extract, and the Urtica dioica extract is 1.3:5.2:4:7; the Urtica dioica extract is prepared by an enzyme-assisted extraction method.
[0031] The Urtica dioica extract is prepared by the following steps: Step S1, crushing Urtica dioica to obtain Urtica dioica powder; the particle size of the Urtica dioica powder is 200 μm; Step S2, adding the Urtica dioica powder and a composite enzyme to an ethanol aqueous solution, heating under reflux, constant-temperature enzymolysis, enzyme inactivation, cooling, to obtain an extract; the mass ratio of the Urtica dioica powder, the composite enzyme, and the ethanol aqueous solution is 6.8:0.4:155; the composite enzyme includes hemicellulase and pectinase in a mass ratio of 1.4:1.2; the mass fraction of the ethanol aqueous solution is 8%; the heating refers to heating to 54°C; the heating speed is 3°C / min; the enzymolysis time is 45 min; the enzyme inactivation refers to heat treatment at 90°C under reflux for 14 min; the cooling refers to cooling to 30°C; the cooling speed is 3°C / min; Step S3, centrifuging the extract, taking the supernatant, and spray drying, to complete the preparation; the centrifugation speed is 10,000 rpm; the centrifugation time is 14 min; the inlet air temperature of the spray drying is 185°C; the exhaust air temperature of the spray drying is 90°C; the pressure of the atomizer of the spray drying is 10 MPa.
[0032] A preparation method of a bacteriostatic and anti-hair loss composition, the preparation method comprising the following steps: Mixing Scutellaria baicalensis Georgi extract, white willow bark extract, Lycium fruit extract, and Urtica dioica extract, to complete the preparation.
[0033] Application of a bacteriostatic and anti-hair loss composition in shampoo, the application comprising the following steps: Adding the bacteriostatic and anti-hair loss composition to the shampoo at 2.5% of the mass of the shampoo.
[0034] Embodiment 3 A bacteriostatic and anti-hair loss composition is prepared from the following raw materials: Scutellaria baicalensis Georgi extract, white willow bark extract, Lycium fruit extract, and Urtica dioica extract; the mass ratio of the Scutellaria baicalensis Georgi extract, the white willow bark extract, the Lycium fruit extract, and the Urtica dioica extract is 1.2:4.2:4:7; the Urtica dioica extract is prepared by an enzyme-assisted extraction method.
[0035] The extract of Pteridium aquilinum is prepared by the following steps: Step S1, grinding Pteridium aquilinum to obtain Pteridium aquilinum powder; the particle size of the Pteridium aquilinum powder is 150 μm; Step S2, adding the Pteridium aquilinum powder and a complex enzyme into an ethanol aqueous solution, heating under reflux, constant temperature enzymolysis, enzyme inactivation, cooling, to obtain an extract; the mass ratio of the Pteridium aquilinum powder, the complex enzyme and the ethanol aqueous solution is 5:0.36:155; the complex enzyme comprises hemicellulase and pectinase in a mass ratio of 1.1:1.2; the mass fraction of the ethanol aqueous solution is 7%; the heating refers to heating to 50℃; the heating speed is 2.5℃ / min; the enzymolysis time is 40 min; the enzyme inactivation refers to heat treatment at 90℃ for 10 min under reflux; the cooling refers to cooling to 27℃; the cooling speed is 2.5℃ / min; Step S3, centrifuging the extract, taking the supernatant, and spray drying, to complete the preparation; the centrifugation speed is 9000 rpm; the centrifugation time is 12 min; the inlet air temperature of the spray drying is 182℃; the exhaust air temperature of the spray drying is 88℃; the pressure of the atomizer of the spray drying is 10 MPa.
[0036] A preparation method of a bacteriostatic and anti-hair loss composition, the preparation method comprising the following steps: Mixing a Scutellaria baicalensis Georgi extract, a white willow bark extract, a Lycium fruit extract and a Pteridium aquilinum extract, to complete the preparation.
[0037] An application of a bacteriostatic and anti-hair loss composition in shampoo, the application comprising the following steps: Adding the bacteriostatic and anti-hair loss composition to the shampoo at 1.2% of the mass of the shampoo.
[0038] Comparative Example 1 On the basis of Example 3, mixing a Scutellaria baicalensis Georgi extract, a white willow bark extract, a Lycium fruit extract and a Pteridium aquilinum extract is changed to mixing a white willow bark extract, a Lycium fruit extract and a Pteridium aquilinum extract, and the rest remains unchanged.
[0039] Comparative Example 2 On the basis of Example 3, mixing a Scutellaria baicalensis Georgi extract, a white willow bark extract, a Lycium fruit extract and a Pteridium aquilinum extract is changed to mixing a Scutellaria baicalensis Georgi extract, a Lycium fruit extract and a Pteridium aquilinum extract, and the rest remains unchanged.
[0040] Comparative Example 3 On the basis of Example 3, the Scutellaria extract, white willow bark extract, Lycium fruit extract and Uva-ursi extract are mixed into the Scutellaria extract, white willow bark extract and Uva-ursi extract, and the rest remains unchanged.
[0041] Comparative Example 4 On the basis of Example 3, the Scutellaria extract, white willow bark extract, Lycium fruit extract and Uva-ursi extract are mixed into the Scutellaria extract, white willow bark extract and Lycium fruit extract, and the rest remains unchanged.
[0042] Comparative Example 5 On the basis of Example 3, the hemicellulase is replaced by an equal amount of pectinase, and the rest remains unchanged.
[0043] Comparative Example 6 On the basis of Example 3, the pectinase is replaced by an equal amount of hemicellulase, and the rest remains unchanged.
[0044] Comparative Example 7 On the basis of Example 3, the complex enzyme is replaced by an equal amount of an ethanol aqueous solution (mass fraction 7%), and the rest remains unchanged.
[0045] Comparative Example 8 On the basis of Example 3, the mass fraction of the ethanol aqueous solution is changed from 7% to 10%, and the rest remains unchanged.
[0046] Comparative Example 9 On the basis of Example 3, the ethanol aqueous solution is replaced by an equal amount of deionized water, and the rest remains unchanged.
[0047] Test Experiment 1 Antibacterial performance test: the antibacterial and anti-shedding compositions prepared in Example 3 and Comparative Examples 1-9 are added to the same base shampoo (antibacterial and anti-shedding composition to shampoo mass ratio of 1.2:100) to obtain sample solutions, and the antibacterial performance test is carried out according to Appendix C, Part C4 of GB 15979-2002, wherein the test bacteria is Malassezia furfur (ATCC 44344) and the action time is 20 min.
[0048] Table 1 Test Experiment 2 Anti-shedding test: the bacteriostatic anti-shedding compositions prepared in Example 3 and Comparative Examples 1-9 were added to the same base shampoo (mass ratio of bacteriostatic anti-shedding composition to shampoo was 1.2:100) to obtain sample liquids, male people with hair loss problems aged 40-45 years were recruited, professional people used the same size comb to comb the hair of the above-mentioned recruited people (the same conditions of combing method, strength, etc.), 200 people with 60-65 strands of hair falling out were randomly selected as qualified volunteers, and were randomly divided into 10 groups, 20 people in each group, each group used the sample liquid for 60 days (the washing frequency was two days of washing and one day of stopping, the first day was to start washing, and the sample liquid could only be washed once on the day when it was needed, and the sample liquid was 15 mL each time), the professional people combed the qualified volunteers again on the 61st day, and the average number of hair falling out in each group was calculated, and the number of people with discomfort during use was counted.
[0049] Table 2 As can be seen from the combination of Table 1 and Table 2, the bacteriostatic anti-shedding composition prepared in the present application is not only mild and safe, but also has excellent bacteriostatic performance, and can play a good anti-shedding effect after being applied and added to shampoo, and the bacteriostatic performance and the anti-shedding effect show a high positive correlation.
[0050] In the description in the specification, the description of the reference terms "one embodiment", "an example", "a specific example" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.
[0051] The above is only an example and description of the concept of the present application, and those skilled in the art can make various modifications or supplements or use similar ways to replace the described specific embodiments, as long as they do not deviate from the concept of the present application or exceed the scope defined by the present claims, which should belong to the protection scope of the present application.
Claims
1. The anti-dandruff composition as claimed in claim 1, wherein: The mass ratio of the Scutellaria extract, the white willow bark extract, the Lycium fruit extract, and the Urena extract is 1-1.3:3.5-5.2:4:
7.
2. The anti-dandruff composition as claimed in claim 1 wherein: The Urena extract is prepared by an enzyme-assisted extraction method.
3. The anti-dandruff composition as claimed in claim 1 wherein: The Urena extract is prepared by the following steps: Step S1, crushing Urena to obtain Urena powder; Step S2, adding the Urena powder and a compound enzyme into an ethanol aqueous solution, heating under reflux, constant-temperature enzymolysis, enzyme inactivation, cooling, and obtaining an extract; Step S3, centrifuging the extract, taking the supernatant, and spray drying, to complete the preparation.
4. The anti-dandruff composition according to claim 4, wherein: In Step S2, the mass ratio of the Urena powder, the compound enzyme, and the ethanol aqueous solution is 4.2-6.8:0.35-0.4:
155.
5. The anti-dandruff composition as claimed in claim 4 wherein: In Step S2, the compound enzyme includes hemicellulase and pectinase with a mass ratio of 1-1.4:1.
2.
6. The anti-dandruff composition according to claim 4, wherein: In Step S2, the mass fraction of the ethanol aqueous solution is 5-8%.
7. The anti-dandruff composition according to claim 4, wherein: In Step S2, the heating is to heat to 48-54℃, and the enzymolysis time is 30-45 min.
8. A process for the preparation of the bacteriostatic anti-dandruff composition according to any one of claims 1 to 8, characterized in that: The preparation method includes the following steps: Mixing the Scutellaria extract, the white willow bark extract, the Lycium fruit extract, and the Urena extract, to complete the preparation.
9. Use of the anti-dandruff bacteriostatic composition according to any one of claims 1 to 8 in a shampoo, characterized in that: The application includes the following steps: Adding the bacteriostatic and anti-hair loss composition to the shampoo at 1.2-2.5% of the mass of the shampoo. The mass ratio of the Scutellaria extract, the white willow bark extract, the Lycium fruit extract, and the Urena extract is 1-1.3:3.5-5.2:4:
7. The Urena extract is prepared by an enzyme-assisted extraction method. The Urena extract is prepared by the following steps: Step S1, crushing Urena to obtain Urena powder; Step S2, adding the Urena powder and a compound enzyme into an ethanol aqueous solution, heating under reflux, constant-temperature enzymolysis, enzyme inactivation, cooling, and obtaining an extract; Step S3, centrifuging the extract, taking the supernatant, and spray drying, to complete the preparation. In Step S2, the mass ratio of the Urena powder, the compound enzyme, and the ethanol aqueous solution is 4.2-6.8:0.35-0.4:
155. In Step S2, the compound enzyme includes hemicellulase and pectinase with a mass ratio of 1-1.4:1.
2. In Step S2, the mass fraction of the ethanol aqueous solution is 5-8%. In Step S2, the heating is to heat to 48-54℃, and the enzymolysis time is 30-45 min. The preparation method includes the following steps: Mixing the Scutellaria extract, the white willow bark extract, the Lycium fruit extract, and the Urena extract, to complete the preparation. The application includes the following steps: Adding the bacteriostatic and anti-hair loss composition to the shampoo at 1.2-2.5% of the mass of the shampoo.