Traditional Chinese medicine compound acyclovir gel ointment capable of being applied on large area to treat HPV verruca verruca

Abstract

By utilizing the characteristic that acyclovir cannot corrode normal skin when being externally applied, the acyclovir is mixed with traditional Chinese medicine composite components which are capable of softening cutin, high in permeability, expanding microcirculation and free of ablativity, so that the acyclovir can be applied trustingly, sufficiently, timely, expanded and repeatedly, the effective components of the acyclovir can penetrate into and reside on a basal layer of epidermis for a long time and continuously act on HPV strains, and the treatment effect of the acyclovir is improved. And finally clearing. A large piece of HPV verruca which is lately bred for many years can be removed, and the total treatment effect can reach 90% or above; within a considerable period when no specific medicine exists at present, the ointment can be used as a major ointment for treating the HPV verruca vulgaris (can be matched with an antiviral medicine at the same time).

Description

TECHNICAL FIELD The present application relates to the field of medicine, in particular to a kind of external medicine composition, which is a western medicine asinovum gel combined with traditional Chinese medicine active ingredients, and is used for treating skin warts and papilloma caused by human papilloma virus HPV. BACKGROUND

[0001] We know that the persistence and concealment of human papilloma virus HPV make the infected and carrier subconsciously spread and spread. In addition to direct sexual transmission (which may have little effect on men, but has a great impact on women's deep vagina and cervix), a large amount of transmission is non-specific public transmission, such as wearing thin pants (women wearing only underwear under skirts) in hot weather, sitting on public seats (seats in shopping malls, restaurants, government offices, schools, parks, hospitals, waiting rooms, and seats on trains, ships and airplanes), and using bath towels and bedclothes in guest rooms during business trips. The virus spreads from the surface to the inside near the buttocks. It has been proved that five or six high-risk subtypes can cause anal cancer and female cervical cancer. Even the ten or so low-risk subtypes silently breed on the head and face, and as people age and their immune function declines, they will one by one "emerge" and show warts and papilloma all over the face and neck. "Love of beauty, old also have" … … "No face to see people" … … Not only affects beauty, but also erodes the trigeminal nerve, causing facial paralysis and deafness! It is conservatively estimated that nearly 10% of the population is infected, which means that more than 100 million people in China are infected (in most cases, the virus silently breeds for many years before "appearing" and becoming warts and papilloma)! But the industry is helpless about this virus, and it is difficult to treat and prevent.

[0002] The current situation of human resistance to "human papilloma virus" is that due to the extreme and high specificity of the virus to human tissue cells, it is extremely difficult and costly to culture it in vitro and experiment on animal skin, resulting in no successful laboratory cases in screening drugs and verifying the corresponding relationship of inhibiting the virus. At present, it is "catching big and releasing small": although there is no good choice for drugs and therapies to inhibit and kill the virus, we have no choice but to "give priority to prevention" and focus on preventing cervical cancer. The virus has been successfully transplanted into animal internal organs together with human cells, contributing to the development of HPV vaccine. However, there is no good medical and pharmaceutical approach to the damage of HPV virus to the skin (manifested as warts and papilloma - although not cancerous, but the total amount of infection is large), and we can only passively wait.

[0003] The current treatment of HPV warts, nodules is: one, found one, "point processing" one. Common two "point processing" way, one is the drug "point processing", such as 1 western medicine fluorouracil cream (directly on HPV, block its DNA synthesis), 2 western medicine miquimod (immunomodulator, indirect effect on HPV: activate local immunity, induce cytokine clearance virus), 3 single traditional Chinese medicine podophyllum emodi, calophyllum inophyllum oil, 4 traditional Chinese medicine compound wumiao water xian paste, etc. Two is the physical "point processing", such as laser ablation, liquid nitrogen freeze. But, these physical and chemical "point" method, there are two major problems, risk:

[0004] One, scar, especially in the face and neck. It is well known that HPV virus, mainly in the deepest layer of human epidermis - basal layer, close to the dermis. The virus with its stubbornness, persistence, recognized as a stubborn virus in the medical community. If long-term, multiple point this kind of drug, it is inevitable to hurt the surrounding healthy skin. And "point burning freeze", in order to "uproot", have to try to "deep", lead to slightly careless, hurt the dermis, prevent! According to relevant statistics, the crowd in our country, "easy scar" constitution, accounting for nearly 15%, (African people easy scar up to 50%). This means that the traditional point drug therapy, (face) scar probability is 15%; and physical erosion method, is more likely to hurt innocent dermis, make scar risk can increase to more than 30%! So big probability, so big risk, is to keep those small nodules, small Qiuqiu, is likely to become a larger scar?

[0005] Two, hidden dangers. Although the risk (hurt healthy skin) implementation of "point processing", "uproot", but not "nest end", adjacent to the survival of the virus, colony, still lurking! Industry lamented the so-called "recurrence rate" of 40%, in fact, it should be "again rate", "new rate" 40%! Our treatment practice found that the virus strain, contamination, silently growing five years, every square centimeter of a (warts), will also be hibernation, more than one. Such as a dollar coin area of about 5 cm2 (4.91 cm2), about performance, a head, means that a coin range, will also be hibernation four, five. Twenty years of patients, a coin range, will be hibernation ten to twenty or more strains!

[0006] Three, some parts are not convenient to "point processing". Such as ear canal, tongue pharynx, operation is difficult, perineum, anus, ashamed to be damaged, so as to delay. (Ear, ear lobe recruit the virus, generally is the side of the pillow when sleeping by the ear infected. This place can not be taken lightly: not early clear virus, will lead to tinnitus, even deafness)

[0007] Therefore, the "point treatment" method misses many, delays the disease, and allows the virus to hide and grow! Although it is "low risk" and not fatal, it can cause warts on the face and neck in old age, causing frustration, depression, and self-esteem, which may affect physical health and shorten life. The key is that it is "low risk" for men, but it can be transmitted and deep into the cervix, which may reverse to "high risk"!

[0008] The current skin medical community is generally "pessimistic and helpless" about the lack of specific drugs, and "passive and expectant" about "self-immune clearance". However, the problem is that one, according to general rules, human body functions, including immune function, begin to decline after the age of thirty; two, even if young adults, due to marital and work pressures, staying up late, and other factors, combined with pesticide residues and random additives in diet, how many people have good body functions and normal immunity? You can see that in the locker room of the gym, the backs of young men (often overlooked when looking in the mirror) are noticeably stained, about 20%!(meaning that the proportion of carriers, or more than 40% — a major hidden danger for cervical cancer in women). Three, the obesity rate in China is showing a sustained upward trend, and by 2025, the adult overweight rate will be 34.3%(about 340 million people), the adult obesity rate will be 16.4%(about 160 million people), and the combined overweight / obesity rate will be 50.7%(more than half of all adults). Our research has found that obesity and high blood pressure are highly related to HPV. The reason is simple: peripheral blockage, immune anti-inflammatory factors, difficult to travel, and the total amount of immune function to the deep layer of the epidermis is too small, far from enough to counteract the virus — a large number of people with high blood pressure and obesity have decreased immune function.

[0009] In summary, the current "point treatment" treatment method is only "urgent" and expects the so-called self-immune clearance, which misleads the public, is passive and delays the disease, and has endless consequences. SUMMARY

[0010] We want to develop an active external ointment that can be applied in large areas without damaging the surrounding healthy skin and causing scarring, and can also stimulate and remove latent HPV.

[0011] The principle of the present application is to fully utilize the mature technology and affordable price of the western medicine acitimomab, and mix it with active Chinese medicine ingredients to make it the main force for treating HPV, especially for low-risk skin warts.

[0012] As is known to all, aciclovir is a drug specially used for treating herpes zoster and herpes simplex virus, and is not recommended for treating HPV in the Recommended Guidelines, and only a few literatures mention that it has a little auxiliary effect on treating HPV. In fact, we believe that aciclovir is not the main drug for treating herpes virus, but only an auxiliary drug, with a recurrence rate of 10% or even more than 50%. Strictly speaking, aciclovir is not the best drug for treating herpes virus, and it is not the best drug developed and screened. One of the main reasons is that the skin infected with herpes virus can gather, go up and hide in the ganglion far from the skin through the nerve ending. The viral genome exists in the form of a ring in the nerve cells, almost no virus protein is produced, making it difficult for the immune system to recognize, and it is in a "dormant" state. But it can be easily activated repeatedly and return to the prickle layer and basal layer of the original skin, proliferate in large quantities and become herpes! The general drug property of externally applied aciclovir ointment can only reach the prickle layer, and it is "out of reach" for the basal layer. Taking aciclovir internally has no effect on the hidden toxins in the ganglion.

[0013] In fact, the second, human papillomavirus HPV, as mentioned above, because its laboratory ex vivo animal skin experiments are difficult, and the human body directly oral or topical acyclovir, the effect is not good. And now, we have basically studied: it can be fully utilized! According to our years of treatment test, research found that as long as in place, sufficient, sufficient time, acyclovir on human papillomavirus, there are obvious inhibition, inactivation effect! HPV virus compared with herpes virus, its easy to handle is that it has no way back (up to the ganglion) of herpes virus, only need drug action time is longer. We found that oral acyclovir dispersible tablets (dose according to the instructions), a week or so, unexpectedly, a wide range of subcutaneous, the HPV virus was irritated, "hit", present, performance for obvious swelling, hyperemia - before can't see, can't touch, no pain no itching. Continue to take medicine to two weeks, even three weeks, basically stop, Cian, flat, equivalent to complete a "big clean-up". But, especially emphasize, oral acyclovir a few cases of success, can only prove that it has obvious effect on HPV virus, but can not be recommended to the public: the reason is that the HPV virus is stubborn, industry all know; sufficient drug, in place (the deepest layer of epidermis - basal layer), sufficient time, effect for more than 20 days, can ensure that the basic clear. But the drug has instability, such as in the pharmacy counter, temperature is high, put for a long time, it is easy to denaturation, inactivation; oral, not wait for delivery to the subcutaneous lesion, intestinal degradation of more than 30%. More importantly, its "easy crystallization" - even take ten days or so, its crystallization, block the renal tubules risk, will be greatly enhanced - and continuous use of 20 ~ 30 days or more, is the best window period of killing the virus! Risk probability, not recommended.

[0014] But, oral, has proved its obvious effect, is not the right time. Next is simple: use acyclovir, external coating, "normal skin" has no harm (actually, as mentioned earlier, seemingly so-called "normal skin", subcutaneous probability all hidden a large number of strains), mixed into softening keratin, strong permeability, expansion of microcirculation, no ablation of traditional Chinese medicine complex ingredients, as "drug primer", made into ointment, with gel is appropriate - transparent, smear on the face, similar to long-term smearing of skin care products, almost invisible coating, (traditional addition of talc cream, although the moisturizing is better, but the smearing trace is too obvious.) Conveniently at any time, sufficient, sufficient time, expansion, multiple smearing, so that acyclovir active ingredients, can be in-depth, long stay in the basal layer of epidermis, continuous effect on HPV strains, so as to finally clear. The addition of auxiliary traditional Chinese medicine, the skin, mucous membrane is sure to feel the micro irritability, but will not erode "innocent". On the other hand, this dose of skin drug, from the bottom of the epidermis, reverse through the dermis, affect the probability of the kidney, is very small.

[0015] The compound ointment can mobilize and eliminate large pieces of HPV warts that have been growing for years. Although it cannot be said that all patients' warts can be completely and thoroughly eliminated, the total treatment effect can reach 90% for this human stubborn disease, and it is expected to be used as the main ointment for HPV warts.

[0016] The technical solution of the present application is: the present application provides a kind of combined with western medicine's acyclovir gel ointment, it is characterized in that, comprising the following weight parts of components: in the total drug component of the ointment, the component of A. chemical medicine acyclovir as main drug accounts for 60% to 70%;B. the total amount of auxiliary Chinese herbal medicine component accounts for 30% to 40% (30% to 40% of the total amount of acyclovir), and the proportion of auxiliary materials and total drug component of the ointment is 5% to 20%;Detailed step, auxiliary Chinese herbal medicine includes the following equal components, 1. improve microcirculation, promote the component of ice flakes, 2. promote the component, relieve pain and itching menthol, 3. blood circulation, Rhizoma Chuanxiong, 4. heat and dampness, immune regulation of Sophora flavescens, 5. dispelling blood stasis and relieving pain, anti-inflammatory analgesic myrrh, 6. heat-clearing and detoxifying, and passing through meridians, with multiple activities such as anti-inflammatory, antibacterial and immune regulation Honeysuckle, 7. improve local blood circulation, resolvent and analgesic frankincense, 8. improve microcirculation, regulate immunity of Turmeric, 9. promote the component, relieve pain and itching camphor;C. conventional preparation adjuvant, including carbomer 940, glycerol, propylene glycol, triethanolamine, paraffin, nitrogen ketone, hyaluronic acid, purified water, add according to industry practice, thick or dilute, little effect.

[0017] The beneficial effects of the present application are: under the current situation that there is no specific medicine for HPV virus for a considerable period of time, there is something, which is better than nothing! The medicine is cheap, simple and easy to use, and can be applied like cosmetics and skin care products. A large number of latent strains can be triggered to prevent the strain from growing and becoming uncontrollable due to negligence. The effect is high and the incidence of adverse reactions is almost zero. Cotton swabs can be avoided and the medicine can be applied directly with the index finger. It does not erode the fingers and does not require assistance. Direct touch is more conducive to the discovery and application of subcutaneous strains in hidden and painful areas such as the scalp, back, mouth and perineal triangle. It also has three characteristics: first, two special methods are added: one is the "trial stone" method and the reagent method. For sporadic warts visible to the naked eye, before implementing the traditional "point processing" method, the exposed wart body and the surrounding skin are expanded to the size of two coins and applied three to five times a day for three to five days. Small warts will begin to wither and even disappear. The key is that a large number of unexpected strains will appear. "Fortunately, there is no risk of leaving scars and enduring this meaningless operation of dropping a wart." This avoids unnecessary work. If the wart is too large, traditional point processing must be continued. Second, the virus is too stubborn, but a small number of "escaped fish" survive again and grow to a "face-saving" size and density, which takes about ten years. Life experiences two or three applications and care, which can be used for ten years. Fifty-year-old people use it once, and sixty-year-old people use it once, which completes a lifetime. There is no need for major operations and no need for large amounts of long-term use of expensive Chinese medicines. Third, the improved mixture of the present application, which contains the traditional Chinese medicine acyclovir gel, has stronger penetration and residence. It can still be used to suppress herpes simplex virus HSV and herpes zoster virus VZV, and the effect will be better (the present complex medicine can penetrate the epidermis and the dermis, suppress and extinguish the herpes simplex virus in the nerve endings in the dermis, greatly reduce the total amount of residual toxins, and reduce the recurrence damage). DETAILED DESCRIPTION

[0018] An example is provided: A. Acyclovir accounts for 70%, B. The total amount of components of auxiliary Chinese herbal medicine (ice flakes, menthol, Szechuan lovage, sophora, myrrh, honeysuckle, frankincense, turmeric, camphor, and equal) accounts for 30%, and the two types are the total medicinal components; C. Add 30% of the total amount of medicinal components as a preparation auxiliary material (carbomer 940, glycerol, propylene glycol, triethanolamine, paraffin, azone, hyaluronic acid, and purified water), which completes the ratio of the present application.

[0019] During the first and second month of the treatment (3 to 5 times a day): A. The first half month, oral administration of the medicine, in combination with oral acyclovir dispersible tablets, can accelerate the effect and appearance. After that, change to relatively safe Chinese patent medicines, such as "anti-virus oral liquid", "Zhibai Dihuang Pill", "Longdan Xiegan Pill", etc. B. For patients taking antihypertensive drugs, under the premise of continuous monitoring by sphygmomanometer to ensure safety, a small amount of drug can be temporarily reduced to prevent excessive reduction of blood pressure, which is not conducive to the delivery of sufficient oral acyclovir and immune factors to the subcutaneous lesions. (For example, if the systolic pressure is 135 after taking the constant antihypertensive drug, a small amount of drug can be cut off to maintain the systolic pressure at about 150 during the treatment period, which can help accelerate healing.) C. Supplementary heat therapy can accelerate the effect. At home, you can use a low-grade electric hair dryer to blow the affected area, or buy an infrared bulb and place it close to the skin at 40-50°C for 20-30 minutes of mild baking. E. If you have a cold during the treatment period, the body's increased anti-inflammatory response will help accelerate detoxification.

Claims

1. The present application provides a traditional Chinese medicine compound acyclovir gel ointment, characterized in that, The ointment comprises the following components by weight: A. acyclovir as the main drug, accounting for 60-70% of the total medicinal components; B. auxiliary Chinese herbal medicine, accounting for 30-40% of the total medicinal components; and C. auxiliary formulation, accounting for 5-20% of the total medicinal components. The auxiliary Chinese herbal medicine comprises the following components:

1. borneol, 2. menthol, 3. chuanxiong, 4. kuh-seng, 5. myrrh, 6. honeysuckle, 7. frankincense, 8. yujin, and 9. camphor. The conventional formulation auxiliary comprises carbomer 940, glycerol, propylene glycol, triethanolamine, paraffin, azone, hyaluronic acid, and purified water.

2. The method of claim 1, wherein: A. acyclovir, accounting for 70%; B. auxiliary Chinese herbal medicine, including borneol, menthol, chuanxiong, kuh-seng, myrrh, honeysuckle, frankincense, yujin, and camphor, accounting for 30%; and C. formulation auxiliary, accounting for 30% of the total medicinal components.