External traditional Chinese medicine composition for growing hair and preventing alopecia as well as preparation method and application of external traditional Chinese medicine composition

Abstract

The invention discloses an external traditional Chinese medicine composition for growing hair and preventing alopecia as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The external traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of fresh ginger, 8 to 15 parts of herba cistanche, 6 to 12 parts of flos elaeagni angustifoliae, 5 to 10 parts of nigella glandulifera seeds, 5 to 10 parts of Xinjiang sabina chinensis seeds and 3 to 8 parts of folium mori. The six medicinal materials including the fresh ginger, the cistanche deserticola, the russianolive flowers, the nigella glandulifera seeds, the sabina chinensis fruits and the mulberry leaves are scientifically matched and cooperate with one another, the effects are achieved in the aspects of promoting blood circulation, nourishing hair follicles, resisting inflammation and bacteria, adjusting the scalp environment, resisting oxidation and the like, and therefore the remarkable hair growing and hair loss preventing effects are achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to an external traditional Chinese medicine composition for hair growth and hair loss prevention and a preparation method and application thereof. BACKGROUND

[0002] Hair loss is a common health problem in today's society and a common dermatological disease, which not only affects the appearance of patients, but also may bring great psychological pressure to patients. Its occurrence is related to many factors such as heredity, mental stress, endocrine disorder, and imbalance of scalp microecology. With the acceleration of life pace, the increase of work pressure and the influence of environmental factors, the incidence of hair loss is increasing year by year, and it shows a trend of youth.

[0003] At present, the methods for treating hair loss mainly include chemical drug therapy and hair transplantation surgery. Chemical drug therapy such as minoxidil and finasteride can alleviate the symptoms of hair loss to a certain extent, but most of them may be accompanied by scalp irritation, itching, redness and other adverse reactions during use, and hair loss is easy to recur after drug withdrawal, and the side effects are large. Hair transplantation surgery is expensive, and is limited by the number of donors and the patient's own conditions, and is difficult to popularize.

[0004] Traditional Chinese medicine has accumulated rich experience in preventing hair loss and promoting hair growth. Through the ways of regulating scalp blood, nourishing hair follicles and improving scalp microcirculation, the effect of preventing hair loss and promoting hair growth is achieved. In the prior art, some traditional Chinese medicine compositions are applied in this field, such as the formula taking cypress leaves, radix falcaliae, ginseng as main components, but these formulas have the problems of single efficacy, weak targeting and insufficient innovation. At the same time, some medicine materials with characteristics of minority medicine, such as black seed and Xinjiang round pine fruit, have not been fully developed and utilized in the potential of preventing hair loss and promoting hair growth, and the synergistic effect with other traditional Chinese medicines has not been deeply researched.

[0005] Therefore, it is of important practical significance to develop an external traditional Chinese medicine composition which takes natural traditional Chinese medicine as raw material, has high safety and can synergistically play the effects of preventing hair loss and promoting hair growth. SUMMARY

[0006] The purpose of the present application is to provide an external traditional Chinese medicine composition for hair growth and hair loss prevention and a preparation method and application thereof, so as to solve the problems existing in the prior art. Through experimental verification, the external traditional Chinese medicine composition provided by the present application has significant effects of hair growth and hair loss prevention, and provides a new method for hair growth and hair loss prevention.

[0007] In order to achieve the above-mentioned purpose, the present application provides the following solutions.

[0008] The application provides a hair-growing and hair-loss-preventing external traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: ginger 10-20 parts, cistanche 8-15 parts, Elaeagnus angustifolia L. flower 6-12 parts, black nightshade seed 5-10 parts, Sabina tatarica L. fruit 5-10 parts and mulberry leaf 3-8 parts.

[0009] Preferably, the composition comprises the following raw materials in parts by weight: ginger 15 parts, cistanche 12 parts, Elaeagnus angustifolia L. flower 9 parts, black nightshade seed 7 parts, Sabina tatarica L. fruit 7 parts and mulberry leaf 5 parts.

[0010] The application also provides a preparation method of the external traditional Chinese medicine composition, which is characterized by comprising the following steps:

[0011] The raw materials are weighed in parts by weight, crushed and mixed to obtain a mixture, water is added, the mixture is soaked and heated for extraction, filtration is performed, and the first filtrate and the filter residue are collected;

[0012] Water is added to the filter residue, the filter residue is heated again for extraction, filtration is performed, and the second filtrate is collected;

[0013] The first filtrate and the second filtrate are combined, and the thick paste obtained by concentration under reduced pressure is the external traditional Chinese medicine composition.

[0014] Optionally, the weight ratio of the mixture to water is 1: (8-12), the soaking time is 1-2 hours, and the heating extraction time is 1.5-2.5 hours.

[0015] Preferably, the weight ratio of the mixture to water is 1:10, the soaking time is 1.5 hours, and the heating extraction time is 2 hours.

[0016] Optionally, the mass ratio of the filter residue to water is 1: (6-10), and the heating extraction time is 1-1.5 hours.

[0017] Preferably, the mass ratio of the filter residue to water is 1:8, and the heating extraction time is 1.2 hours.

[0018] The application also provides application of the external traditional Chinese medicine composition in the preparation of a hair-growing and hair-loss-preventing external preparation.

[0019] The application also provides a hair-growing and hair-loss-preventing external preparation, which comprises the external traditional Chinese medicine composition.

[0020] Optionally, the dosage form of the hair-growing and hair-loss-preventing external preparation comprises a lotion.

[0021] The application discloses the following technical effects:

[0022] This invention scientifically combines six medicinal herbs: ginger, cistanche deserticola, oleaster flower, black cumin seed, Xinjiang juniper fruit, and mulberry leaf. These herbs work synergistically to promote blood circulation, nourish hair follicles, reduce inflammation and bacteria, regulate the scalp environment, and provide antioxidant effects, thus achieving significant hair growth and hair loss prevention effects. The innovation of this invention compared to existing technologies lies in:

[0023] 1. Novel combination of medicinal materials: It adopts a unique combination of medicinal materials, including ginger, Cistanche deserticola, Elaeagnus angustifolia flowers, Nigella foenum-graecum seeds, Juniperus chinensis fruits, and mulberry leaves. Among them, Elaeagnus angustifolia flowers, Nigella foenum-graecum seeds, and Juniperus chinensis fruits are rarely used in traditional Chinese medicine compositions for hair growth and hair loss prevention, forming a distinctive formula.

[0024] 2. Significant synergistic effect: The various medicinal materials complement each other in terms of efficacy and enhance each other's effects. They can not only exert their individual effects, but also work together on the scalp and hair follicles to improve the overall hair growth and hair loss prevention effect.

[0025] 3. High safety: All medicinal materials used are natural Chinese herbs. Through reasonable formulation and extraction processes, they are highly safe, have few side effects, and are suitable for long-term use. Detailed Implementation

[0026] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0027] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, is also included within the scope of this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0028] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0029] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0030] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0031] This invention addresses the shortcomings of existing technologies by selecting six medicinal materials based on traditional Chinese medicine theory: ginger, cistanche deserticola, jujube flower, black cumin seed, Xinjiang juniper fruit, and mulberry leaf. Among them, black cumin seed and Xinjiang juniper fruit are characteristic ingredients of ethnic minority medicine. These materials are scientifically combined with other medicinal materials to form a topical composition that has both hair growth and hair loss prevention effects, filling the relevant technological gap.

[0032] Ginger: Warm in nature and pungent in taste, ginger has the effects of relieving exterior syndromes and dispelling cold, warming the middle jiao and stopping vomiting, resolving phlegm and relieving cough, and detoxifying fish and crab poisoning. In this composition, ginger can promote scalp blood circulation, stimulate hair follicles, and provide a good environment for hair growth. Modern research shows that components such as gingerol in ginger have anti-inflammatory and antioxidant effects, which help improve scalp inflammation.

[0033] Cistanche deserticola: It is warm in nature and sweet and salty in taste. It tonifies kidney yang, nourishes essence and blood, and moistens the intestines to relieve constipation. It nourishes hair follicles, providing nutrients for hair growth, enhancing hair resilience, and reducing hair loss. Studies have found that Cistanche deserticola contains various active ingredients, such as phenylethyl glycosides, which have antioxidant and cell proliferation-promoting effects.

[0034] Sand date flower: It has a sweet taste and warm properties, and has the effects of relieving cough and asthma, and nourishing the brain with its fragrance.

[0035] Black cumin seeds: sweet and pungent in taste, warm in nature, they have the effects of tonifying the kidneys and brain, regulating menstruation, promoting lactation, and diuresis. They are rich in nutrients and active substances, possessing antioxidant, anti-inflammatory, and hair growth-promoting effects, thus enhancing hair vitality.

[0036] Xinjiang juniper fruit: It has the effects of dispelling wind and cold, promoting blood circulation and reducing swelling, removing spots and promoting hair growth.

[0037] Mulberry leaves: cold in nature, sweet and bitter in taste, have the effects of dispersing wind-heat, clearing the lungs and moisturizing dryness, and clearing the liver and improving eyesight. Mulberry leaves can clear heat and promote diuresis, regulate scalp oil secretion, create a healthy growth environment for hair, and contain flavonoids and other components that have antioxidant effects.

[0038] Example 1

[0039] A topical Chinese medicine composition for promoting hair growth and preventing hair loss includes the following raw materials in parts by weight: 10 parts ginger, 8 parts Cistanche deserticola, 6 parts Elaeagnus angustifolia flowers, 5 parts Nigella sativa seeds, 5 parts Xinjiang Juniper fruit, and 3 parts mulberry leaves.

[0040] Its preparation method is as follows:

[0041] (1) Weigh each raw material according to the weight proportions, wash and dry them separately, and then crush them into coarse powder;

[0042] (2) Mix the crushed raw materials evenly, add water at 8 times the total weight of the raw materials, soak for 1 hour, heat to boiling, maintain a gentle boil for 1.5 hours, filter, and collect the first filtrate and residue;

[0043] (3) Add water to the filter residue in a volume of 6 times the total weight of the raw materials, heat to boiling, maintain a gentle boil for 1 hour, filter, and collect the second filtrate;

[0044] (4) Combine the two filtrates and concentrate them under reduced pressure to a thick paste with a relative density of 1.05 (60°C) to obtain the external Chinese medicine composition.

[0045] Example 2

[0046] A topical Chinese medicine composition for promoting hair growth and preventing hair loss includes the following raw materials in parts by weight: 20 parts ginger, 15 parts Cistanche deserticola, 12 parts Elaeagnus angustifolia flowers, 10 parts Nigella foenum-graecum seeds, 10 parts Juniperus chinensis fruits from Xinjiang, and 8 parts mulberry leaves.

[0047] Its preparation method is as follows:

[0048] (1) Weigh each raw material according to the weight proportions, wash and dry them separately, and then crush them into coarse powder;

[0049] (2) Mix the crushed raw materials evenly, add water at 12 times the total weight of the raw materials, soak for 2 hours, heat to boiling, maintain a gentle boil for 2.5 hours, filter, and collect the first filtrate and residue;

[0050] (3) Add water to the filter residue in a volume of 10 times the total weight of the raw materials, heat to boiling, maintain a gentle boil for 1.5 hours, filter, and collect the second filtrate;

[0051] (4) Combine the two filtrates and concentrate them under reduced pressure to a thick paste with a relative density of 1.10 (60°C) to obtain the external Chinese medicine composition.

[0052] Example 3

[0053] A topical Chinese medicine composition for promoting hair growth and preventing hair loss includes the following raw materials in parts by weight: 15 parts ginger, 12 parts Cistanche deserticola, 9 parts Elaeagnus angustifolia flowers, 7 parts Nigella foenum-graecum seeds, 7 parts Juniperus chinensis var. chinensis fruits, and 5 parts mulberry leaves.

[0054] Its preparation method is as follows:

[0055] (1) Weigh each raw material according to the weight proportions, wash and dry them separately, and then crush them into coarse powder;

[0056] (2) Mix the crushed raw materials evenly, add water at 10 times the total weight of the raw materials, soak for 1.5 hours, heat to boiling, maintain a gentle boil for 2 hours, filter, and collect the first filtrate and residue.

[0057] (3) Add water to the filter residue in a volume of 8 times the total weight of the raw materials, heat to boiling, maintain a gentle boil for 1.2 hours, filter, and collect the second filtrate;

[0058] (4) Combine the two filtrates and concentrate them under reduced pressure to a thick paste with a relative density of 1.08 (60°C) to obtain the external Chinese medicine composition.

[0059] Example 4

[0060] A topical Chinese medicine composition for promoting hair growth and preventing hair loss includes the following raw materials in parts by weight: 12 parts ginger, 10 parts Cistanche deserticola, 8 parts Elaeagnus angustifolia flowers, 6 parts Nigella sativa seeds, 6 parts Juniperus chinensis fruit from Xinjiang, and 4 parts mulberry leaves.

[0061] The preparation method is the same as in Example 3.

[0062] Comparative Example 1

[0063] A topical Chinese medicine composition differs from Example 3 in that it lacks ginger, and the weight of the remaining ingredients is appropriately adjusted to make the total weight the same as in Example 3. Specifically, it consists of: 15 parts of Cistanche deserticola, 12 parts of Elaeagnus angustifolia flowers, 10 parts of Nigella foenum-graecum seeds, 10 parts of Juniperus chinensis var. chinensis fruits, and 8 parts of mulberry leaves.

[0064] The preparation method is the same as in Example 3.

[0065] Comparative Example 2

[0066] A topical Chinese medicine composition differs from Example 3 in that it lacks Cistanche deserticola, and the weight proportions of the remaining raw materials are appropriately adjusted to make the total weight the same as that of Example 3. Specifically, it consists of 18 parts ginger, 11 parts jujube flower, 9 parts black cumin seed, 9 parts Xinjiang juniper fruit, and 7 parts mulberry leaf.

[0067] The preparation method is the same as in Example 3.

[0068] Comparative Example 3

[0069] A topical Chinese medicine composition differs from Example 3 in that it lacks Xinjiang juniper fruit, and the weight proportions of the remaining raw materials are appropriately adjusted so that the total weight is the same as that of Example 3. Specifically, it consists of 17 parts ginger, 14 parts Cistanche deserticola, 10 parts Elaeagnus angustifolia flowers, 8 parts Nigella sativa seeds, and 6 parts mulberry leaves.

[0070] The preparation method is the same as in Example 3.

[0071] Comparative Example 4

[0072] A topical Chinese medicine composition differs from Example 3 in that the weight parts of ginger and black cumin seeds are replaced, specifically: 15 parts black cumin seeds, 12 parts Cistanche deserticola, 9 parts Elaeagnus angustifolia flowers, 7 parts ginger, 7 parts Xinjiang Juniper fruit, and 5 parts mulberry leaves.

[0073] The preparation method is the same as in Example 3.

[0074] Application examples

[0075] To verify the hair growth and hair loss prevention effects of the traditional Chinese medicine composition provided by this invention, the following experiments were conducted.

[0076] The topical Chinese medicine compositions prepared in Examples 1-5 and Comparative Examples 1-4 were prepared into lotions: each thick paste was mixed with 2 wt% PEG-40 hydrogenated castor oil and 3 wt% glycerin, pH 5.5.

[0077] Healthy adults reporting hair loss symptoms were recruited. Those who lost more than 10 hairs during a 60-step combing exercise participated in the product trial. Each group consisted of 20 participants. They used the shampoos prepared with the herbal compositions from Examples 1-4 and Comparative Examples 1-4, respectively. After washing their scalp daily, they applied 2 mL of the shampoos evenly to the entire scalp area using a graduated dropper or syringe, massaging with fingertips for 3-5 minutes until absorbed. This was continued for 3 months. The number of hairs lost and the amount of new hair growth were observed and recorded for each group to assess efficacy. The overall effective rate was calculated as (cured + significantly effective + effective) / total number of cases × 100%.

[0078] The evaluation criteria for the efficacy of treatments for hair loss are as follows:

[0079] Cure: No hair loss, or less than 25 hairs per day;

[0080] Significant effect: Hair loss is significantly reduced, or the amount of hair loss per day is between 25 and 50 strands;

[0081] Effective: Hair loss still occurs, but the daily hair loss is between 50 and 75 strands.

[0082] Ineffective: No change in hair loss, or more than 75 hairs are lost per day.

[0083] The evaluation criteria for the treatment of new hair growth are as follows:

[0084] Cured: All new hair has grown out and is the same as normal hair;

[0085] Significant effect: More than 50% of new hair grows out, and a significant amount of vellus hair turns into terminal hair;

[0086] Effective: More than 10% of new hair grows, but the growth is slow;

[0087] Ineffective: No new hair regrowth or less than 10% of new hair regrowth, or hair falling out while growing.

[0088] Table 1. Improvement in hair loss in each trial group

[0089] Group Cured Effective Effective Ineffective Total effective rate Example 1 4 8 7 1 95% Example 2 5 8 6 1 95% Example 3 6 9 5 0 100% Example 4 5 9 5 1 95% Comparative Example 1 2 4 7 7 65% Comparative Example 2 2 3 9 6 70% Comparative Example 3 1 2 6 11 45% Comparative Example 4 0 4 6 10 50%

[0090] Table 2. New hair growth in each trial group

[0091] Group Cured Effective Effective Ineffective Total effective rate Example 1 3 7 6 4 80% Example 2 4 8 4 4 80% Example 3 5 8 4 3 85% Example 4 4 7 5 4 80% Comparative Example 1 1 4 5 10 50% Comparative Example 2 2 3 5 10 50% Comparative Example 3 1 2 5 12 40% Comparative Example 4 0 3 6 11 45%

[0092] As shown in Table 1, the topical Chinese medicine compositions prepared in Examples 1-4 of this invention can significantly improve the amount of hair loss, with the total effective rate of Example 3 reaching 100%. This indicates that the topical Chinese medicine compositions provided by this invention may produce a significant synergistic effect. Furthermore, the data from Comparative Examples 1-4 show that when certain components in the topical Chinese medicine compositions of this invention are removed or their dosage ratios are changed, the efficacy significantly deteriorates. This demonstrates that the types and dosage ratios of each herb in the Chinese medicine composition are crucial to the hair loss prevention efficacy of the topical Chinese medicine compositions of this invention.

[0093] As shown in Table 2, the topical Chinese medicine compositions prepared using Examples 1-4 of this invention can significantly promote hair growth, with the total effective rate of Example 3 reaching 85%. This indicates that the topical Chinese medicine compositions provided by this invention may produce a significant synergistic effect. Furthermore, the data from Comparative Examples 1-4 show that when certain components in the topical Chinese medicine compositions of this invention are removed or their dosage ratios are changed, the therapeutic effect significantly deteriorates. This demonstrates that the types and dosage ratios of each herb in the Chinese medicine composition are crucial to the hair growth efficacy of the topical Chinese medicine compositions of this invention.

[0094] The above experimental results show that volunteers using the herbal compositions of Examples 1-4 of this invention experienced a significant reduction in hair loss and a significant increase in new hair growth, with Example 3 showing the best effect. Volunteers using the herbal compositions of Comparative Examples 1-4, however, showed significantly less reduction in hair loss and increase in new hair growth compared to Example 4. This indicates that the herbal composition of this invention has a good synergistic effect among the medicinal materials, significantly enhancing hair growth and preventing hair loss.

[0095] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A topical traditional Chinese medicine composition for promoting hair growth and preventing hair loss, characterized in that, The external application Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts ginger, 8-15 parts Cistanche deserticola, 6-12 parts Elaeagnus angustifolia flowers, 5-10 parts Nigella sativa seeds, 5-10 parts Juniperus chinensis fruits, and 3-8 parts mulberry leaves.

2. The topical traditional Chinese medicine composition as described in claim 1, characterized in that, The ingredients include the following parts by weight: 15 parts ginger, 12 parts Cistanche deserticola, 9 parts Elaeagnus angustifolia flowers, 7 parts Nigella foenum-graecum seeds, 7 parts Xinjiang Juniper fruit, and 5 parts mulberry leaves.

3. The method for preparing the external application traditional Chinese medicine composition as described in claim 1 or 2, characterized in that, Includes the following steps: Weigh each raw material according to the weight proportions, crush and mix them to obtain a mixture, add water, soak and heat to extract, filter, and collect the first filtrate and filter residue; Add water to the filter residue, heat again to extract, filter, and collect the second filtrate; The first and second filtrates are combined and concentrated under reduced pressure to obtain a thick paste, which is the aforementioned topical Chinese medicine composition.

4. The preparation method according to claim 3, characterized in that, The weight ratio of the mixture to water is 1:(8-12), the soaking time is 1-2 hours, and the heating extraction time is 1.5-2.5 hours.

5. The preparation method according to claim 4, characterized in that, The weight ratio of the mixture to water is 1:10, the soaking time is 1.5 hours, and the heating extraction time is 2 hours.

6. The preparation method according to claim 3, characterized in that, The mass ratio of the medicinal residue to water is 1:(6-10), and the reheating extraction time is 1-1.5 hours.

7. The preparation method according to claim 6, characterized in that, The mass ratio of the medicinal residue to water is 1:8, and the reheating extraction time is 1.2 hours.

8. The use of the topical Chinese medicine composition as described in claim 1 or 2 in the preparation of topical preparations for hair growth and hair loss prevention.

9. A topical preparation for promoting hair growth and preventing hair loss, characterized in that, Includes the topical Chinese medicine composition as described in claim 1 or 2.

10. The topical preparation for hair growth and hair loss prevention as described in claim 9, characterized in that, The dosage forms of the hair growth and hair loss prevention topical preparations include shampoos.