Coating method of powerful anti-glare sugar-coated tablet

Abstract

The invention relates to a coating method of a powerful anti-glare sugar-coated tablet. The coating method comprises the following steps: coating an isolating layer; coating a mixed slurry layer; coating a sugar coating layer; according to the preparation method disclosed by the invention, a novel mixed slurry coating method is adopted, the simple syrup and the talcum powder are prepared into mixed slurry, and the mixed slurry is uniformly dripped in a production process by using an automatic dripping method of a coating gun, so that the non-uniformity of manually scattering the talcum powder is reduced, the production operation is simple and convenient, the coating difficulty is reduced, and the operation error rate is reduced; the quality risk of an intermediate product is reduced, dust flying and pollution to the production environment in the production process are avoided, and the weight increment of the coating is reduced. According to the method, the use amount of talcum powder is only 1 / 2 of that of a traditional method, and the rejection rate of cut pieces is reduced to 2%-3% from 4%-5% of that of the original method.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically a coating method for a sugar-coated tablet of a potent anti-vertigo drug. Background Technology

[0002] Qiangli Dingxuan tablets are traditional sugar-coated tablets. The uncoated tablet weighs 0.35g, and the sugar-coated tablet weighs 0.6g. The purpose of sugar coating on Qiangli Dingxuan tablets is to (1) protect them from light and moisture and isolate them from air; (2) mask unpleasant odors, thus making them more palatable to patients; and (3) improve their appearance and make them easier to swallow. Traditional sugar coating of Qiangli Dingxuan tablets uses gelatin paste as an isolation layer and sucrose and talc as excipients. The conventional weight gain of sugar coating is 70% to 90%.

[0003] The traditional method for sugar-coating strong anti-glare tablets involves using a non-porous coating pan, preparing a syrup from sucrose and purified water, and then first adding gelatin syrup to form an insulating layer, followed by sprinkling talcum powder, adding simple syrup to form a powder coating layer, adding more syrup to form a sugar coating layer, and finally sprinkling insect wax powder for polishing. This traditional method for coating strong anti-glare tablets uses a large amount of talcum powder, resulting in a high scrap rate and significant increase in tablet weight. The production process relies heavily on the operator's skill and experience, and the dust generated during operation causes considerable environmental pollution. Summary of the Invention

[0004] The purpose of this invention is to optimize the production process of sugar coating for strong glaze tablets, reduce the unevenness of manually sprinkling talcum powder, simplify production operations, reduce coating difficulty, reduce operational error rate, reduce intermediate product quality risk, reduce talcum powder usage, avoid dust flying and pollution of the production environment during the production process, and reduce coating weight gain.

[0005] To solve the above-mentioned technical problems, the present invention provides a coating method for a high-strength anti-glare sugar-coated tablet, characterized by comprising the following steps:

[0006] Step 1: Apply an isolation layer:

[0007] Put the strong dizziness tablets into the coating pan, preheat to 50℃~80℃, add the prepared gelatin paste, and make it evenly adhere to the surface of the tablets.

[0008] Add a small amount of talcum powder to make it adhere evenly to the surface of the tablet;

[0009] After the pills in the pot have dispersed, turn on the fan to heat and dry the coating layer thoroughly. Then wrap a layer of isolation layer. Repeat this process 3 or 4 times, wrapping 3 or 4 layers of isolation layer.

[0010] Step 2, Apply the grout layer:

[0011] After the isolation layer is completed, continue rotating the pan. When the tablet bed temperature reaches 30℃~60℃, turn on the peristaltic pump and turn on the coating drip gun to evenly drip the mixed slurry. After the tablet surface is evenly moistened, the mixed slurry layer is evenly adhered to the tablet surface. After the tablets in the pan are dispersed, turn on the fan to heat. After the tablets are fully dry, coat them with another layer of mixed slurry. Repeat 18~22 times to make the tablets fully dry until all the edges of the tablets disappear, the tablet surface is flat and uniform, the base color is completely covered, and there are no spots or black edges.

[0012] Step 3: Apply the sugar coating:

[0013] After the coating syrup layer is completed, continue to rotate the pot. When the tablet bed temperature reaches 35℃, turn on the peristaltic pump and turn on the coating drip gun to evenly drip the monosaccharide syrup. After the tablet surface is evenly moistened, make it evenly adhere to the tablet surface. After the tablets in the pot are dispersed, turn on the fan to heat the tablets to dry them thoroughly until all the edges of the tablets disappear, the tablet surface is flat, uniform, bright and clean, and the average tablet weight is qualified.

[0014] Step 4, Polishing:

[0015] Rotate the pot to turn the tablets over, allowing the remaining moisture to evaporate slowly. Sprinkle in an appropriate amount of insect wax powder and rotate and rub until the tablets are shiny. Then add the remaining insect wax powder and continue rotating the pot until the surface of the tablets is bright.

[0016] Step 5, Drying the tablets: Place the tablets in a stainless steel tray and push them into the drying room to dry to room temperature.

[0017] Furthermore, in step 1, the coating machine rotates at 8-9 revolutions per minute and the preheating time is 5-10 minutes when preheating the tablets.

[0018] Furthermore, when applying the isolation layer, each time 1 / 3 to 1 / 4 of the total weight of gelatin paste is added.

[0019] Furthermore, when mixing the slurry layer, the temperature of the slurry is 60±10℃, the air inlet frequency is 25~40Hz, the filter pressure difference is 200~400Pa, the air inlet temperature is 60℃~80℃, the rotation speed is 8~10 rpm, and the slurry addition rate is 20~30s / time.

[0020] Furthermore, when coating the syrup layer, the amount of syrup added is 20-30 seconds per cycle, the air inlet temperature is 30-35℃, and the rotation speed is 8-10 revolutions per minute.

[0021] Furthermore, during polishing, the temperature of the pot is 20℃~35℃, the rotation frequency is 5~7 revolutions / minute, and the ratio of adding insect white wax powder twice is 2:1.

[0022] Furthermore, the mixture is made by adding talcum powder to the simple sugar syrup at a weight ratio of 1:3 to 3.5, stirring for 40 to 60 minutes until homogeneous, keeping warm, and then setting aside.

[0023] Furthermore, the gelatin paste is composed of a gelatin solution and a simple syrup, with a weight ratio of 1:8 to 10.

[0024] Furthermore, the simple syrup is made by adding sucrose and purified water in a weight ratio of 2:1 to 1.2. The sucrose is added to the purified water in a jacketed kettle and boiled until the sucrose is completely dissolved. Then, it is filtered through a 100-mesh sieve into a stainless steel insulated container and is freshly made before use to prevent conversion.

[0025] Furthermore, the gelatin solution is prepared by mixing gelatin and purified water at a weight ratio of 1:1.5 to 2.5. The gelatin is added to purified water and heated until completely dissolved, then kept warm and set aside for later use.

[0026] The beneficial effects of this invention are:

[0027] Compared with the traditional sugar coating method, the novel sugar coating method for strong anti-glare tablets has the following advantages, as shown in Table 1:

[0028] Traditional coating methods for strong dizziness-relieving tablets require a large amount of talcum powder; this invention patent uses a novel mixed slurry coating method, requiring only 1 / 2 the amount of talcum powder compared to traditional coating methods.

[0029] Traditional coating methods for strong anti-glare tablets require manual alternating addition of simple syrup and talcum powder during production. This process is difficult, often resulting in uneven surfaces and demanding high skill levels from operators. This invention employs a novel mixed-slurry coating method, creating a mixed slurry from the simple syrup and talcum powder. During production, an automatic dripping method using a coating gun is used to evenly add the slurry, reducing the unevenness caused by manual talcum powder application. This simplifies production, reduces coating difficulty, lowers the error rate, and reduces the risk to intermediate product quality.

[0030] Traditional coating methods for strong dizziness-relieving tablets result in a 70%–90% increase in tablet weight, with a tablet weight range of 0.595g–0.665g. This invention employs a novel mixed-slurry coating method, resulting in a 65%–75% increase in tablet weight, with a tablet weight range of 0.578g–0.613g. This method saves coating materials and improves patient compliance.

[0031] Traditional coating methods for strong anti-glare tablets involve sprinkling talcum powder into the coating. This invention employs a novel mixed slurry coating method, in which all materials are added in liquid form. This avoids dust and environmental pollution during production, and extends the service life and cleaning frequency of the air conditioning system.

[0032] The high-strength anti-glare tablets are produced using the novel mixed syrup and sugar coating method described in this invention, which reduces the scrap rate of the coated tablets from 4% to 5% of the original method to 2% to 3%.

[0033] Compared with the traditional sugar coating method, the new method of mixing syrup and coating sugar with strong anti-glare tablets increases production costs, but reduces the overall material consumption, improves the moisture-proof effect of the sugar coating layer, and enhances the quality of the product.

[0034] project Traditional sugar coating method New sugar coating method talcum powder 2 copies 1 copy scrap rate 4%～5% 1%～2% Average tablet weight 0.595g~0.665g 0.578g~0.613g Weight gain of clothing pieces 70%～90% 65%～75% Operation process The entire process is done manually, which is prone to errors and requires a high level of skill from the operators. Computerized control panels are less prone to errors and require less skill from operators. Coating process The manual application of talcum powder for the coating layer generates significant dust and pollution. The talc powder in the mixing layer is used to make a mixed slurry, and there is no solid dust during the operation, resulting in minimal pollution. Detailed Implementation

[0035] The present invention will be further described in detail below with reference to specific embodiments.

[0036] Example 1

[0037] The coating method for the sugar-coated tablets of the high-strength anti-glare tablets provided in this embodiment involves the following material preparation:

[0038] 350kg (1 million tablets) of strong anti-glare tablets, 200kg of sucrose, 90kg of talc, 1kg of gelatin, and 0.4kg of beeswax. The coating equipment is a perforated flow layer coating machine equipped with a 7-hole coating drip gun.

[0039] When coating, follow these steps:

[0040] Step 1: Preparation of simple sugar syrup: Add 200 kg of sucrose to 100 kg of purified water in a jacketed kettle, boil until the sucrose is completely dissolved, then filter through a 100-mesh sieve into a stainless steel insulated container for later use.

[0041] Step 2: Preparation of gelatin paste: Take 1 kg of gelatin and add 1.5 kg of purified water, heat until completely dissolved, and keep warm to obtain a gelatin solution; take 2.5 kg of gelatin solution and add 20 kg of simple sugar syrup, mix and stir for 30 minutes to obtain gelatin paste, and set aside.

[0042] Step 3: Preparation of the mixed slurry: Take 80 kg of talc powder and add 240 kg of simple sugar syrup, stir evenly, keep warm, and set aside.

[0043] Step 4: Preheat the raw film: Turn on the coating machine, place the high-strength fixed-glaze raw film into the flow layer coating machine, turn on the heating, set the air inlet temperature to 80℃, and rotate the pot body at a speed of 9 revolutions per minute. The preheating time is 5 minutes.

[0044] Step 5: Apply the insulating layer: After preheating the raw film, set the air inlet temperature to 80℃ and rotate the pan at 9 revolutions per minute. Add 1 / 3 of the prepared adhesive solution to make it evenly adhere to the film core, and add 5kg of talc powder. Turn on the fan to heat and allow the coating layer to dry fully; apply 3 layers.

[0045] Step 6: After the isolation layer is completed, continue rotating the pot. Set the temperature of the slurry to 70℃, the air inlet frequency to 40Hz, the filter pressure difference to 200~400Pa, the tablet bed temperature to 30℃~60℃, the air inlet temperature to 70℃~80℃, the rotation speed to 10 rpm, and the slurry addition rate to 30s / time. Turn on the peristaltic pump and turn on the coating drip gun to evenly drip the slurry. After the tablet surface is evenly moistened, make it evenly adhere to the surface of the uncoated tablet. After the tablets are dispersed in the pot, turn on the fan to heat and make the coating layer fully dry. Coat 18 layers until all the edges and corners disappear, the tablet surface is flat and uniform, the base color is completely covered, and there are no color spots or black edges.

[0046] Step 7: Sugar Coating Layer: After the syrup layer is completed, continue rotating the pot. Set the syrup addition rate to 30 seconds per cycle, the air inlet temperature to 35°C, and the rotation speed to 10 rpm. Once the tablet bed temperature reaches the required level, turn on the peristaltic pump and the coating drip gun to evenly drip in the syrup. After the tablet surface is evenly moistened, ensure it adheres evenly to the surface of the uncoated tablet. After the tablets are dispersed in the pot, turn on the fan to heat and fully dry the coating layer until all edges disappear and the tablet surface is flat, uniform, and glossy. Coat 5 layers until the average tablet weight is acceptable.

[0047] Average tablet weight determination method: Weigh 10 tablets, calculate the average tablet weight and record it as follows:

[0048] Serial Number Weight of each piece of clothing (g) Serial Number Weight of each piece of clothing (g) 1 0.578 6 0.587 2 0.582 7 0.576 3 0.585 8 0.579 4 0.585 9 0.587 5 0.579 10 0.582

[0049] Step 8: Polishing: Control the temperature of the pot to 20℃~30℃, set the pot to rotate at 5 revolutions / minute, turn the coating pieces over to allow the remaining moisture to slowly dissipate, sprinkle in 300g of beeswax, rotate and rub until it is shiny, then add another 100g of beeswax, and continue to rotate the pot until the surface of the coating pieces is extremely shiny.

[0050] Step 9: Drying the garment pieces: Control the humidity in the drying room to 20%~35% and the temperature to 20℃~37℃. Place the garment pieces into a stainless steel tray and push it into the drying room to dry until the moisture content is within room temperature. Once the moisture content is measured and found to be within acceptable limits, the garment is ready.

[0051] Example 2

[0052] The coating method for the sugar-coated tablets of the high-strength anti-glare tablets provided in this embodiment involves the following material preparation:

[0053] The preparation method of the sugar-coated tablets of the strong anti-glare tablets: In this embodiment, 350 kg (1 million tablets) of the original strong anti-glare tablets, 220 kg of sucrose, 110 kg of talc, 1 kg of gelatin, and 0.4 kg of beeswax were selected. The coating equipment adopted was a perforated flow layer coating machine equipped with a 7-hole coating drip gun.

[0054] When coating, follow these steps:

[0055] Step 1: Preparation of simple sugar syrup: Add 220 kg of sucrose to 110 kg of purified water in a jacketed kettle, boil until the sucrose is completely dissolved, and then filter it through a 100-mesh sieve into a stainless steel insulated container for later use.

[0056] Step 2: Preparation of gelatin paste: Take 1 kg of gelatin and add 2 kg of purified water, heat until completely dissolved, keep warm, and use as gelatin solution; take 3 kg of gelatin solution and add 27 kg of simple sugar syrup, mix and stir for 30 minutes to obtain gelatin paste, and set aside.

[0057] Step 3: Preparation of the mixed slurry: Take 85 kg of talc powder and add 255 kg of simple sugar syrup, stir evenly, keep warm, and set aside.

[0058] Step 4: Preheat the raw film: Turn on the coating machine, place the high-strength fixed-glaze raw film into the flow layer coating machine, turn on the heating, set the air inlet temperature to 60℃, and rotate the pot body at a speed of 9 revolutions per minute. The preheating time is 8 minutes.

[0059] Step 5: Apply the insulating layer: After preheating the raw film, set the air inlet temperature to 80℃ and rotate the pan at 9 revolutions per minute. Add 1 / 4 of the prepared adhesive solution to make it evenly adhere to the film core, and add 6kg of talc powder. Turn on the fan to heat and allow the coating layer to dry fully; apply 4 layers.

[0060] Step 6: Coating the Mixing Layer: After the isolation layer is completed, continue rotating the pot. Set the temperature of the mixing liquid to 60℃, the air inlet frequency to 30Hz, the filter pressure difference to 200~400Pa, the tablet bed temperature to 30℃~60℃, the air inlet temperature to 70℃~80℃, the rotation speed to 9 rpm, and the mixing liquid addition rate to 25s / time. Turn on the peristaltic pump and turn on the coating drip gun to evenly drip the mixing liquid. After the tablet surface is evenly moistened, make it evenly adhere to the surface of the uncoated tablet. After the tablets inside the pot are dispersed, turn on the fan to heat and make the coating layer fully dry. Coat 19 layers until all the edges and corners disappear, the tablet surface is flat and uniform, the base color is completely covered, and there are no color spots or black edges.

[0061] Step 7: Sugar Coating Layer: After the syrup layer is completed, continue rotating the pot. Set the syrup addition rate to 25 seconds per cycle, the air inlet temperature to 35℃, and the rotation speed to 9 revolutions per minute. When the tablet bed temperature reaches the required level, turn on the peristaltic pump and start the coating drip gun to evenly drip in the syrup. After the tablet surface is evenly moistened, make it evenly adhere to the surface of the uncoated tablet. After the tablets inside the pot are dispersed, turn on the fan to heat and fully dry the coating layer until all the edges disappear and the tablet surface is flat, uniform, bright and clean. Coat 6 layers until the average tablet weight is qualified.

[0062] Average tablet weight determination method: Weigh 10 tablets, calculate the average tablet weight and record it as follows:

[0063] Serial Number Weight of each piece of clothing (g) Serial Number Weight of each piece of clothing (g) 1 0.603 6 0.597 2 0.605 7 0.595 3 0.590 8 0.599 4 0.592 9 0.601 5 0.595 10 0.603

[0064] Step 8: Polishing: Control the temperature of the pot to 20℃~30℃, set the pot to rotate at 6 revolutions / minute, turn the coating pieces over to allow the remaining moisture to slowly dissipate, sprinkle in 300g of beeswax, rotate and rub until it is shiny, then add another 100g of beeswax, and continue to rotate the pot until the surface of the coating pieces is extremely shiny.

[0065] Step 9: Drying the garment pieces: Control the humidity in the drying room to 20%~35% and the temperature to 20℃~37℃. Place the garment pieces into a stainless steel tray and push it into the drying room to dry until the moisture content is within room temperature. Once the moisture content is measured and found to be within acceptable limits, the garment is ready.

[0066] Example 3

[0067] The coating method for the sugar-coated tablets of the high-strength anti-glare tablets provided in this embodiment involves the following material preparation:

[0068] 350kg (1 million tablets) of strong anti-glare tablets, 210kg of sucrose, 115kg of talc, 1kg of gelatin, and 0.4kg of beeswax. The coating equipment is a perforated flow layer coating machine equipped with a 7-hole coating drip gun.

[0069] When coating, follow these steps:

[0070] Step 1: Preparation of simple sugar syrup: Add 210 kg of sucrose to 126 kg of purified water in a jacketed kettle, boil until the sucrose is completely dissolved, and then filter it through a 100-mesh sieve into a stainless steel insulated container for later use.

[0071] Step 2: Preparation of gelatin paste: Take 1 kg of gelatin and add 2.5 kg of purified water, heat until completely dissolved, and keep warm to obtain a gelatin solution; take 3.5 kg of gelatin solution and add 35 kg of simple sugar syrup, mix and stir for 30 minutes to obtain gelatin paste, and set aside.

[0072] Step 3: Preparation of the mixed slurry: Take 90 kg of talc powder, add 315 kg of simple sugar syrup, mix and stir for 60 minutes, keep warm, and set aside.

[0073] Step 4: Preheat the raw film: Turn on the coating machine, place the high-strength fixed-glaze raw film into the flow layer coating machine, turn on the heating, set the air inlet temperature to 50℃, and rotate the pot body at a speed of 8 rpm for 10 minutes.

[0074] Step 5: Apply the insulating layer: After preheating the raw film, set the air inlet temperature to 80℃ and rotate the pan at 8 rpm. Add 1 / 3 of the prepared adhesive solution to ensure it adheres evenly to the film core. Add 8 kg of talc powder and turn on the fan to heat the coating layer until it is fully dry. Apply 3 layers.

[0075] Step 6: Coating the slurry layer: After the isolation layer is completed, continue rotating the pot. Set the temperature of the slurry to 50℃, the air inlet frequency to 25Hz, the filter pressure difference to 200~400Pa, the tablet bed temperature to 30℃~60℃, the air inlet temperature to 60℃~70℃, the rotation speed to 8 rpm, and the slurry addition rate to 20s / time. Turn on the peristaltic pump and turn on the coating drip gun to evenly drip the slurry. After the tablet surface is evenly moistened, make it evenly adhere to the surface of the uncoated tablet. After the tablets inside the pot are dispersed, turn on the fan to heat and make the coating layer fully dry. Coat 22 layers until all the edges disappear, the tablet surface is flat and uniform, the base color is completely covered, and there are no color spots or black edges.

[0076] Step 7: Sugar Coating Layer: After the syrup layer is completed, continue rotating the pot. Set the syrup addition rate to 20 seconds per cycle, the air inlet temperature to 35℃, and the rotation speed to 8 revolutions per minute. When the tablet bed temperature reaches the required level, turn on the peristaltic pump and start the coating drip gun to evenly drip in the syrup. After the tablet surface is evenly moistened, make it evenly adhere to the surface of the uncoated tablet. After the tablets inside the pot are dispersed, turn on the fan to heat and fully dry the coating layer until all the edges disappear and the tablet surface is flat, uniform, bright and clean. Coat 8 layers until the average tablet weight is qualified.

[0077] Average tablet weight determination method: Weigh 10 tablets, calculate the average tablet weight and record it as follows:

[0078] Serial Number Weight of each piece of clothing (g) Serial Number Weight of each piece of clothing (g) 1 0.612 6 0.602 2 0.618 7 0.611 3 0.609 8 0.612 4 0.618 9 0.619 5 0.613 10 0.615

[0079] Step 8: Polishing: Control the temperature of the pot to 20℃~30℃, set the pot to rotate at 7 revolutions / minute, turn the coating pieces over to allow the remaining moisture to slowly dissipate, sprinkle in 300g of beeswax, rotate and rub until it is shiny, then add another 100g of beeswax, and continue to rotate the pot until the surface of the coating pieces is extremely shiny.

[0080] Step 9: Drying the garment pieces: Control the humidity in the drying room to 20%~35% and the temperature to 20℃~37℃. Place the garment pieces into a stainless steel tray and push it into the drying room to dry until the moisture content is within room temperature. Once the moisture content is measured and found to be within acceptable limits, the garment is ready.

[0081] The samples of the high-strength anti-glare tablets obtained in the above three embodiments were tested according to the company's internal quality control standards, and the results are as follows:

[0082] Testing items Internal control standards stipulate Example 1 Example 2 Example 3 Appearance It is complete, smooth, and uniform in color, with a smooth, round surface and no blemishes. Compliant Compliant Compliant Average weight of garment pieces (0.578g~0.613g)±3% 0.578g±3% 0.595g±3% 0.613g±3% Weight gain 65%～75% 65% 70% 75% Disintegration time limit <55 minutes 43 minutes 41 minutes 47 minutes Moisture ＜8% 5.1% 4.8% 4.9%

[0083] The above test results show that the appearance, average tablet weight, tablet weight gain, disintegration time, and moisture content of the sugar-coated tablets prepared in each embodiment all meet the enterprise's internal control standards, and the data stability and reproducibility are good.

[0084] The weight, hardness, and shape of the tablets produced in different batches of Strong Dextromethorphan tablets may vary slightly. The sugar coating process requires that all edges and corners disappear, the tablet surface be flat and uniform, the base color be completely covered, and there be no color spots or black edges. Therefore, there may be slight differences in the weight gain of each batch. The amount of sucrose, talc, and gelatin used also fluctuates slightly, which is reasonable and compliant in the pharmaceutical production process.

[0085] In summary, the sugar-coating preparation methods for the strong anti-glare tablets provided in the above embodiments, by using novel polymer materials to replace traditional gelatin and novel mixing coating methods to replace traditional manual coating methods, result in better moisture-proof effects, smaller tablet weight, and better patient compliance.

[0086] The sugar-coating preparation methods provided in the above three embodiments can also be used for sugar-coating other traditional Chinese medicine preparations such as Gastrodia elata tablets. The resulting sugar-coated Gastrodia elata tablets, after testing, meet the enterprise's internal control standards and comply with national drug standards.

Claims

1. A process for coating of strong dizziness-correcting sugar-coated tablets, characterized by, It comprises the following steps: Step 1, package isolation layer: Take strong Dingxuan piece of the element into the coating pot, preheating to 50-80℃, add the prepared gelatin slurry, make it uniformly adhere to the surface of the tablet; Add a small amount of talc, make it uniformly adhere to the surface of the tablet; After the tablet in the pot is scattered, open the fan heating to make the coating layer fully dry, then package the next layer of isolation layer, repeat 3 or 4 times, package 3 or 4 layers of isolation layer; Step 2, package mixed slurry layer: After the completion of the isolation layer, continue to rotate the pot body, when the tablet bed temperature reaches 30-60℃, open the peristaltic pump, open the coating drop gun, evenly drop the mixed slurry, make the mixed slurry layer uniformly adhere to the surface of the tablet, after the tablet in the pot is scattered, open the fan heating, after the tablet is fully dried, package the next layer of mixed slurry layer, repeat 18-22 times, make the tablet fully dried, until the tablet edges disappear, the tablet surface is flat and uniform, the base color is completely covered, without color spots and black edges; Step 3, package sugar coating layer: After the completion of the mixed slurry layer, continue to rotate the pot body, when the tablet bed temperature reaches 35℃, open the peristaltic pump, open the coating drop gun, evenly drop the single sugar slurry, make the tablet surface uniformly wet, make it uniformly adhere to the surface of the tablet, after the tablet in the pot is scattered, open the fan heating to make the tablet fully dried, until the tablet edges disappear, the tablet surface is flat and uniform, bright and clean, the average tablet weight is qualified; Step 4, polishing: Rotate the pot body, turn over the tablet, make the remaining moisture slowly scattered, add the appropriate amount of insect wax powder, rotate and rub until the tablet is glossy, then add the remaining insect wax powder, continue to rotate the pot body until the tablet surface is bright. Step 5, tablet airing: Put the tablet into a stainless steel tray, push it into the tablet airing room, and air it to room temperature.

2. The coating process for strong daze piece sugar-coated tablets according to claim 1, characterized in that, In step 1, the preheating tablet speed of the coating machine is 8-9 revolutions per minute, and the preheating time is 5-10 minutes.

3. The coating process for the strong dizziness-correcting sugar-coated tablet according to claim 1, characterized by, When the isolation layer is packaged, the amount of gelatin slurry added each time is 1 / 3-1 / 4 of the total weight of the gelatin slurry.

4. The coating method of the strong Dingxuan sugar-coated tablet according to claim 1, characterized in that, When the mixed slurry layer is packaged, the temperature of the mixed slurry is 60±10℃, the air inlet frequency is 25-40Hz, the filter pressure difference is 200-400Pa, the air inlet temperature is 60-80℃, the rotation speed is 8-10 revolutions per minute, and the liquid addition amount of the mixed slurry is 20-30s / time.

5. The coating method of the strong Dingxuan sugar-coated tablet according to claim 1, characterized in that, When the sugar slurry layer is packaged, the liquid addition amount of the single sugar slurry is 20-30s / time, the air inlet temperature is 30-35℃, and the rotation speed is 8-10 revolutions per minute.

6. The coating method of the strong Dingxuan sugar-coated tablet according to claim 1, characterized in that, When polishing, the temperature of the pot body is 20-35℃, the rotation frequency is 5-7 revolutions per minute, and the ratio of the two insect wax powders is 2:

1.

7. The process for coating of strong dizziness-correcting sugar-coated tablets according to any one of claims 1 to 6, characterized in that, The mixed slurry is prepared by adding talc to the single sugar slurry at a weight ratio of 1:3-3.5, stirring for 40-60 minutes until uniform, and keeping warm for standby.

8. The process for coating of strong dizziness-correcting sugar-coated tablets according to any one of claims 1 to 6, characterized in that, The gelatin slurry is composed of gelatin solution and single sugar slurry, and the weight ratio of gelatin solution to single sugar slurry is 1:8-10.

9. The coating process for strong daze piece sugar-coated tablets according to claim 7 or 8, characterized in that, The monosaccharide syrup is prepared by adding sucrose into purified water in a weight ratio of 2:1-1.2, boiling the mixture until the sucrose is completely dissolved, filtering the mixture through a 100-mesh screen into a stainless steel heat preservation tank, and preparing the mixture immediately before use to prevent conversion.

10. The coating process for the strong daze piece sugar-coated tablet according to claim 8, characterized in that, The gelatin solution is prepared by adding gelatin into purified water in a weight ratio of 1:1.5-2.5, heating the mixture until the gelatin is completely dissolved, and heat preserving the mixture for standby use.