Traditional Chinese medicine decoction for treating acne as well as preparation method and application of traditional Chinese medicine decoction

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine decoction for treating acne and a preparation method and application thereof.The traditional Chinese medicine decoction is prepared from, by weight, 20-30 parts of honeysuckle (or replaced with dandelion), 20-30 parts of fructus forsythiae, 3-6 parts of liquorice, 1-3 parts of scorpio, 5-10 parts of selfheal, 10-30 parts of salvia miltiorrhiza, 5-10 parts of spina gleditsiae and 20-30 parts of oriental wormwood. The preparation method comprises the following steps: soaking the traditional Chinese medicinal materials in water, decocting twice, combining filtrate, concentrating, and sub-packaging into 200mL per bag. The decoction has the effects of clearing away heat and toxic materials, promoting diuresis, activating blood, removing stasis The traditional Chinese medicine is suitable for acne caused by heat toxin accumulation, dampness blocking and blood stasis.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a traditional Chinese medicine decoction for treating acne, its preparation method and uses, which has the effects of clearing heat and detoxifying, promoting diuresis and blood circulation, and dispersing nodules and draining pus. Background Technology

[0002] Acne (commonly known as pimples) is a common chronic inflammatory disease of the hair follicles and sebaceous glands, prevalent in adolescents and adults. Clinical manifestations include comedones, papules, pustules, nodules, and cysts. Modern medicine believes that the pathogenesis of acne is closely related to Propionibacterium acnes infection, excessive sebum secretion, abnormal follicular keratinization, excessive androgen secretion, and improper diet. Clinically, acne is often classified into four grades based on skin lesions: Grade I is mild acne, Grades II-III are moderate acne, and Grade IV is severe acne.

[0003] Previous guidelines for acne treatment in China recommended oral medications as the primary treatment, with commonly used drugs including retinoids, minocycline, and anti-androgens. In addition, for moderate to severe acne patients, physical and chemical therapies such as photodynamic therapy, laser therapy, and fractional radiofrequency ablation are also widely used in clinical treatment. However, oral medications often have varying degrees of side effects or drug resistance, and patients frequently fail to adhere to treatment, leading to poor treatment outcomes. Furthermore, physical therapies are expensive, making them unaffordable for some patients.

[0004] Traditional Chinese medicine (TCM) has unique advantages in treating acne, achieving both symptomatic and root-cause relief by regulating dampness, heat, and toxins in the body and balancing Yin and Yang. However, existing TCM formulas often suffer from complex formulations and unstable efficacy, failing to meet patients' needs. Therefore, developing a safe, effective, and simplified TCM decoction is of great significance.

[0005] Current TCM clinical treatment models for acne generally include: ① Differentiation and treatment based on syndrome differentiation: Based on summarizing clinical experience in acne diagnosis and treatment, patients are treated according to their syndrome differentiation; ② Topical application of TCM masks, lotions, etc., to improve local skin symptoms; ③ Regulating the body's organ functions, improving endocrine function, and promoting acne healing through acupuncture, moxibustion, and auricular acupressure. In summary, while TCM treatment of acne in recent years has achieved certain efficacy from the perspective of organ differentiation, it has certain limitations. Its differentiation of skin lesions is still lacking, and the prescriptions are not targeted enough, making it difficult to broadly cover various types of acne. Summary of the Invention

[0006] To address the shortcomings of the aforementioned prior art, this invention provides a decoction for treating acne, applicable to various types of acne; the claimed medicinal ingredient content range is a prescription amount specifically designed for drug development. The composition and dosage of the decoction are highly refined and reasonable, ensuring safe use. For many acne patients who have developed tolerance to Western medicine, especially those with moderate to severe acne, it often achieves twice the result with half the effort, making it particularly suitable for development into a traditional Chinese medicine decoction for treating acne.

[0007] In a first aspect, the present invention provides a traditional Chinese medicine decoction for treating acne, which is made from the following raw materials in parts by weight: honeysuckle 20-30 parts (or dandelion can be used instead), forsythia 20-30 parts, licorice 3-6 parts, scorpion 1-3 parts, prunella vulgaris 5-10 parts, salvia miltiorrhiza 10-30 parts, gleditsia sinensis thorns 5-10 parts, artemisia capillaris 20-30 parts, hawthorn 10-15 parts, and astragalus membranaceus 5-10 parts.

[0008] More preferably, the herbal decoction is made from the following raw materials in parts by weight: 25-30 parts honeysuckle (or dandelion can be used instead), 25-30 parts forsythia, 3-5 parts licorice, 1 part scorpion, 5-10 parts prunella vulgaris, 15-30 parts salvia miltiorrhiza, 10 parts gleditsia sinensis thorns, 30 parts artemisia capillaris, 10-15 parts hawthorn, and 5-10 parts astragalus membranaceus.

[0009] Preferably, the herbal decoction is made from the following raw materials in parts by weight: 30 parts honeysuckle (or dandelion can be used instead), 30 parts forsythia, 5 parts licorice, 1 part scorpion, 10 parts prunella vulgaris, 20 parts salvia miltiorrhiza, 10 parts gleditsia sinensis thorns, 30 parts artemisia capillaris, 15 parts hawthorn, and 5 parts astragalus membranaceus.

[0010] The functions and indications of the traditional Chinese medicine decoction described in this invention are: clearing heat and detoxifying, promoting diuresis and blood circulation, and dispersing nodules and draining pus. It is suitable for acne caused by heat toxin accumulation and dampness obstructing blood stasis, with symptoms such as multiple cysts and nodules on the face, or even developing into bleeding plaques that are easy to rupture, red tongue with white or yellow coating, and wiry and slippery pulse.

[0011] The pharmacological effects of each herb in the formula are described below:

[0012] Honeysuckle: The dried flower buds or newly opened flowers of *Lonicera japonica*, a plant in the Caprifoliaceae family. It has a sweet and cold nature. It enters the lung, heart, and stomach meridians. Its functions include clearing heat and detoxifying, and dispersing wind-heat. Clinically, it is used for dysentery due to heat toxicity, early stages of febrile diseases, wind-heat syndrome, carbuncles, boils, and other skin infections. Modern research shows that its main components include chlorogenic acid, isochlorogenic acid, and luteolin glycosides. Pharmacological studies have confirmed that it has broad-spectrum antibacterial, anti-inflammatory, antipyretic, and immune-enhancing effects.

[0013] Dandelion: The whole herb of *Taraxacum mongolicum* or other plants of the same genus in the Asteraceae family. It tastes bitter and sweet, and is cold in nature. It enters the liver and stomach meridians. Its functions include clearing heat and detoxifying, reducing swelling and dissipating nodules, and promoting diuresis and relieving strangury. Clinically, it is used for mastitis, boils and carbuncles, and lung abscesses with purulent and hemoptytic sputum. Modern research shows that its main components include taraxacin, taraxerol, and caffeic acid. Pharmacological studies have confirmed its antibacterial, anti-inflammatory, diuretic, and hepatoprotective effects.

[0014] Forsythia: The dried fruit of the forsythia plant (Oleaceae family). It tastes bitter and is slightly cold in nature. It enters the heart, lung, and gallbladder meridians. Its functions include clearing heat and detoxifying, reducing swelling and dissipating nodules, and dispersing wind-heat. Clinically, it is used for carbuncles, boils, scrofula, and exogenous wind-heat syndromes. Modern research shows that its main components include forsythoside, forsythoside ester, and rutin. Pharmacological studies have confirmed its antibacterial, anti-inflammatory, antiviral, and immune-enhancing effects.

[0015] Licorice: The dried root and rhizome of the legume *Glycyrrhiza uralensis*. It has a sweet taste and neutral properties. It enters the heart, lung, spleen, and stomach meridians. Its functions include invigorating qi and tonifying the middle jiao, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasms and pain, and harmonizing other herbs. Clinically, it is used for spleen qi deficiency, lung qi insufficiency, carbuncles due to heat toxins, and sore throat. Modern research shows that its main components include glycyrrhizic acid, glycyrrhizin, and flavonoids. Pharmacological studies have confirmed its anti-inflammatory, anti-allergic, hepatoprotective, and immunomodulatory effects.

[0016] Whole scorpion: The dried body of the East Asian scorpion (Scorpionus spp.), a member of the family Scorpionidae. It has a pungent and neutral flavor and enters the liver meridian. Its functions include calming wind and relieving spasms, unblocking meridians and relieving pain, and attacking toxins and dissipating nodules. Clinically, it is used for infantile convulsions, stubborn rheumatism, migraines, carbuncles, and boils. Modern research shows that its main components include whole scorpion venom and various amino acids. Pharmacological studies have confirmed its anticonvulsant, analgesic, anti-inflammatory, and anti-tumor effects.

[0017] Prunella vulgaris: The dried fruit spike of Prunella vulgaris, a plant in the Lamiaceae family. It has a bitter and pungent taste, and is cold in nature. It enters the liver and gallbladder meridians. Its functions include clearing liver heat, improving eyesight, and reducing swelling and lumps. Clinically, it is used for red and swollen eyes, headaches and dizziness, scrofula, and goiter. Modern research shows that its main components include prunellain, flavonoids, and volatile oils. Pharmacological studies have confirmed its anti-inflammatory, antibacterial, antihypertensive, and antitumor effects.

[0018] Danshen (Salvia miltiorrhiza): The dried root of *Salvia miltiorrhiza*, a plant in the Lamiaceae family. It has a bitter taste and is slightly cold in nature. It enters the Heart and Liver meridians. Its functions include promoting blood circulation and removing blood stasis, nourishing blood and calming the mind, cooling blood and reducing swelling. Clinically, it is used for chest and abdominal pain, irregular menstruation, amenorrhea, dysmenorrhea, and postpartum pain due to blood stasis. Modern research shows that its main components include tanshinone, cryptotanshinone, and tanshinone. Pharmacological studies have confirmed its antithrombotic, microcirculation-improving, anti-myocardial ischemia, and anti-tumor effects.

[0019] Gleditsia sinensis thorns: The dried thorns of the Gleditsia sinensis plant (family Fabaceae). It has a pungent and warm nature. It enters the liver and stomach meridians. Its functions include reducing swelling and promoting pus drainage, and killing parasites. Clinically, it is mainly used for carbuncles, boils, lung abscesses, intestinal abscesses, and abdominal pain due to intestinal parasites. Modern research shows that its main components include triterpenoid saponins and flavonoids. Pharmacological studies have confirmed its antibacterial, anti-inflammatory, antiviral, and antitumor effects.

[0020] Artemisia capillaris: The dried aerial parts of Artemisia capillaris or Artemisia capillaris, belonging to the Asteraceae family. It tastes bitter and pungent, and is slightly cold in nature. It enters the spleen, stomach, liver, and gallbladder meridians. Its functions include clearing heat and promoting diuresis, and relieving jaundice. Clinically, it is used for damp-heat jaundice, difficulty urinating, etc. Modern research shows that its main components include chlorogenic acid, caffeic acid, and flavonoids. Pharmacological studies have confirmed that it has choleretic, hepatoprotective, antibacterial, and anti-inflammatory effects.

[0021] Raw hawthorn: The dried, ripe fruit of the hawthorn plant (Crataegus pinnatifida), belonging to the Rosaceae family. It has a sour and sweet taste, and is slightly warm in nature. It enters the spleen, stomach, and liver meridians. Its functions include promoting digestion, strengthening the stomach, regulating qi, and dispersing blood stasis. Clinically, it is used for abdominal pain due to food stagnation, abdominal pain due to diarrhea, and amenorrhea due to blood stasis. Modern research shows that its main components include hawthorn acid, ursolic acid, and flavonoids. Pharmacological studies have confirmed that it has digestive, lipid-lowering, antioxidant, and anti-fatigue effects.

[0022] Astragalus: The dried root of *Astragalus mongholicus* or *Astragalus membranaceus*, both belonging to the legume family. It has a sweet taste and is slightly warm in nature. It enters the lung and spleen meridians. Its functions include promoting pus drainage, astringing sores, and promoting tissue regeneration. Clinically, it is used for qi deficiency and fatigue, poor appetite and loose stools, carbuncles that are difficult to heal, and chronic ulcers that do not heal. Modern research shows that its main components include polysaccharides, flavonoids, saponins, and folic acid. Pharmacological studies have confirmed that it has immunomodulatory, anti-inflammatory, antioxidant, and blood sugar regulating effects.

[0023] Its formula solution, i.e., its mechanism of action, is as follows:

[0024] From the perspective of skin lesion differentiation, the core pathogenesis of acne, especially moderate to severe acne, is the accumulation of heat toxins and dampness obstructing blood stasis. Based on this pathogenesis, this formula was created using the principles of clearing heat and detoxifying, promoting diuresis and blood circulation, and dispersing nodules and draining pus. Honeysuckle and dandelion in the formula are both heat-clearing and detoxifying herbs, and are particularly effective in reducing swelling. Forsythia, in addition to clearing heat and detoxifying, also has the effect of reducing swelling and dispersing nodules, and is known as a "holy medicine for sores." The combination of these two herbs specifically targets clearing heat and detoxifying, dispersing nodules and eliminating swelling. Salvia miltiorrhiza, which is cold in nature, is used to clear heat, cool the blood, promote blood circulation, and relieve pain, addressing the pathogenesis of heat toxins entering the blood. Artemisia capillaris, bitter, pungent, and slightly cold, is used to purge heat and disperse stagnant heat, clearing heat, promoting diuresis, and relieving stagnation. Prunella vulgaris, bitter and cold, clears heat from the head and face, disperses nodules and reduces swelling. Gleditsia sinensis thorns reduce swelling and drain pus, specifically treating existing phlegm-dampness abscesses and other pathological products. The addition of hawthorn berries helps digestion and prevents food stagnation from generating heat, while licorice root clears heat and detoxifies, harmonizing the effects of the other herbs. Professor Zhao Bingnan, the founder of Traditional Chinese Medicine dermatology, believed that scorpion, with its pungent and neutral properties, enters the liver meridian and can attack toxins and disperse nodules. Using a small amount as a medicinal ingredient guides the medicine into the collaterals, dispelling wind and unblocking the collaterals without generating heat, attacking toxins and dispersing nodules without harming the body's vital energy. The combined herbs primarily clear heat and detoxify, while also addressing dampness and phlegm, dispersing nodules and draining pus, and clearing stubborn pathogens from the meridians. The cooling effect is not stagnant, allowing heat toxins to be resolved and phlegm and dampness to be eliminated. Astragalus root tonifies qi, both promoting pus drainage and wound healing, and can be used in appropriate amounts for mid-stage sores that are difficult to ulcerate or for late-stage sores that fail to heal.

[0025] In summary, the formula described in this invention is safe and effective in treating acne, especially moderate to severe acne. It can effectively improve the rash and symptoms of acne patients. The formula is refined and is very suitable for development into a traditional Chinese medicine preparation.

[0026] Secondly, the present invention provides a method for preparing the aforementioned traditional Chinese medicine decoction, comprising the following steps:

[0027] Soaking, double boiling, filtrate merging and concentration.

[0028] The detailed operation of the preparation method is as follows:

[0029] 1. Weigh out each raw material according to the proportion, add water and soak for 30 minutes. The amount of water should be 8-10 times the total weight of the medicinal materials.

[0030] 2. Bring to a boil over high heat, then simmer over low heat for 30-40 minutes. Filter to obtain the initial decoction.

[0031] 3. Add 6-8 times the amount of water to the dregs again, simmer over low heat for 20-30 minutes, and filter to obtain the re-decocted liquid;

[0032] 4. Combine the initial decoction and the second decoction, and concentrate them to 2-3 times the original volume to obtain the Chinese herbal decoction.

[0033] Thirdly, the present invention also provides the use of the aforementioned traditional Chinese medicine decoction in the preparation of acne treatment drugs.

[0034] Furthermore, the drug is an oral liquid, granules, or capsules. Detailed Implementation

[0035] The present invention will be further described below with reference to examples, typical clinical cases, and clinical studies.

[0036] Example 1:

[0037] A traditional Chinese medicine decoction for treating acne is prepared as follows: The following amounts of raw materials are by weight: 30 parts honeysuckle, 30 parts forsythia, 6 parts licorice, 1 part scorpion, 10 parts prunella vulgaris, 30 parts salvia miltiorrhiza, 5 parts gleditsia sinensis thorns, 30 parts artemisia capillaris, 15 parts hawthorn, and 5 parts astragalus. Before decocting, soak the prepared herbs in water for 30 minutes. Use a clay pot for decocting, using enough water to submerge the herbs. Before boiling, use high heat; after boiling, maintain a gentle simmer for 30-40 minutes. Filter out the dregs to obtain the first decoction. Add 6-8 times the amount of water to the dregs and decoct again using the above method to obtain the second decoction. Mix the first and second decoctions, concentrate to 2-3 times their original volume, and divide into two bags, each approximately 200mL. This constitutes the decoction of this invention, which is the daily dosage for an adult.

[0038] Take twice daily, morning and evening. One course of treatment is 14 days. Mild to moderate cases usually improve after 1-2 courses, while severe cases require 4-6 courses for significant improvement. During treatment, discontinue all other related medications; avoid fried, spicy, sweet, and greasy foods, as well as hot fruits; limit dairy intake to no more than 400ml per day.

[0039] The traditional Chinese medicine for treating acne in this embodiment can treat various types of acne, and has a particularly outstanding effect on patients with moderate to severe acne.

[0040] Example 2:

[0041] A traditional Chinese medicine decoction for treating acne is prepared by weighing out the following ingredients: 30 parts dandelion, 30 parts forsythia, 6 parts licorice, 1 part scorpion, 10 parts prunella vulgaris, 10 parts salvia miltiorrhiza, 10 parts gleditsia sinensis thorns, 30 parts artemisia capillaris, 15 parts hawthorn, and 5 parts astragalus membranaceus. The other ingredients are the same as in Example 1.

[0042] The traditional Chinese medicine for treating acne in this embodiment can treat various types of acne, and has a particularly outstanding effect on acne patients who do not respond well to oral minocycline or whose acne is prone to recurrence.

[0043] Example 3:

[0044] A traditional Chinese medicine decoction for treating acne is prepared by weighing out the following ingredients: 30 parts dandelion, 30 parts forsythia, 5 parts licorice, 1 part scorpion, 9 parts prunella vulgaris, 20 parts salvia miltiorrhiza, 5 parts gleditsia sinensis thorns, 30 parts artemisia capillaris, 15 parts hawthorn, and 6 parts astragalus membranaceus. Other ingredients are the same as in Example 1.

[0045] The traditional Chinese medicine used in this embodiment for treating acne can treat various types of acne, and has a particularly prominent effect on patients with a lot of dark red pigmentation on the face and scalp.

[0046] Typical clinical cases

[0047] Case 1:

[0048] Mr. Jia, male, 14 years old, presented on January 12, 2020. Chief complaint: Recurrent facial rash for 1 year, worsening in the past month. One year ago, red papules and pimples appeared on his face. He self-medicated with topical mupirocin ointment, which provided some relief, but he did not receive systematic treatment, and the rash recurred repeatedly. In the past month, the rash rapidly worsened. Topical mupirocin was ineffective, and oral cefaclor provided slight relief, but many new rashes still appeared. Current symptoms: Multiple red papules, nodules, and cysts on the face, with occasional pain. Bowel movements were normal. Sleep was good, with no dry mouth or bitter taste. Physical examination: Multiple red follicular papules, pimples, and cysts on the forehead, cheeks, jaw, and neck. Pale red tongue with yellow coating, wiry pulse. Traditional Chinese Medicine diagnosis: Facial toxicity, spleen deficiency with dampness, phlegm-dampness obstructing the meridians; Western medicine diagnosis: Moderate to severe acne. He was treated with the traditional Chinese medicine formula described in Example 1. After more than a month, the rash stabilized, with occasional new rashes that subsided, leaving scars. The acne was essentially cured.

[0049] Case 2:

[0050] Mr. Su, male, 15 years old, first visit on October 29, 2021. Chief complaint: Facial rash for over a year, worsening in the past 4 weeks. For the past year and a half, red papules and pimples appeared on his face. Oral minocycline 50mg twice daily for 6 weeks was ineffective, followed by cephalosporins, which also proved ineffective. Five weeks ago, he took prednisone 15mg once daily at another hospital, which he reduced to 5mg once daily on his own. He stopped taking it two weeks ago. One week ago, the rash suddenly worsened, and he switched to oral minocycline 50mg twice daily, which he has been taking since then. The itching and pain have significantly increased. Current symptoms: Multiple red papules, nodules, and cysts on the face, chest, and back, with significant itching and pain, but no fever or chills. Bowel movements every two days, not dry, poor sleep. Physical examination: Multiple red follicular papules, nodules, and cysts with seborrheic dermatitis on the forehead, cheeks, jaw, neck, chest, and back, with visible blood crusts; red tongue with white coating, wiry pulse. Traditional Chinese Medicine diagnosis: Facial acne due to damp-heat and phlegm-dampness obstructing the liver meridian; Western medicine diagnosis: Moderate to severe acne. After three months of treatment with modified traditional Chinese medicine based on the formula in Example 2, the rash stabilized, with occasional new rashes that subsided, leaving only scars; the acne was essentially cured.

[0051] Case 3:

[0052] Mr. Sun, male, 24 years old, came for consultation on July 9, 2018. Chief complaint: Recurrent facial rashes for 1 year. No systematic treatment had been received. Current symptoms: Multiple red and dark red papules and pimples on the face, without itching or pain; stools were sometimes dry and sometimes loose. Physical examination: Multiple red and dark red follicular papules and pimples on both cheeks; red tongue with a white and greasy coating; wiry pulse. Traditional Chinese medicine diagnosis: Boils due to spleen deficiency and damp-heat syndrome; Western medicine diagnosis: Folliculitis. He was treated with modified traditional Chinese medicine based on the formula in Example 3. After one month, the rash improved, with a few new rashes appearing on both cheeks, and bowel movements became regular.

[0053] Clinical research

[0054] Due to national policy reasons, the traditional Chinese medicine formulas described in this invention have not undergone rigorous randomized controlled clinical trials.

[0055] I. Clinical Data

[0056] (I) General information: Among the 42 patients, there were 27 males and 15 females; the youngest was 13 years old and the oldest was 38 years old; the severity of the disease was classified according to the Pillsbury classification, including: 4 cases of grade I, 2 cases of grade II, 15 cases of grade III and 21 cases of grade IV.

[0057] (II) Symptom Characteristics: This condition typically begins in adolescence, with women often experiencing onset earlier than men, although men are more prone to developing moderate to severe acne. Skin lesions primarily occur on the face, especially the forehead, cheeks, and chin, followed by the chest, back, and shoulders. Initially, it presents as comedones, which in severe cases manifest as nodules, cysts, or conglobate acne, accompanied by pain and the formation of cysts and sinus tracts.

[0058] (III) Diagnostic criteria: This article uses the "Chinese Clinical Dermatology" edited by Zhao Bian and published by Jiangsu Science and Technology Press (5th edition, April 2017) as the standard; and uses clinical manifestations and laboratory tests as the basis to exclude other diseases.

[0059] II. Treatment Methods

[0060] (I) Self-prescribed formula: Honeysuckle (or dandelion) 30 parts, Forsythia 30 parts, Licorice 5 parts, Scorpion 1 part, Prunella vulgaris 10 parts, Salvia miltiorrhiza 20 parts, Gleditsia sinensis 10 parts, Artemisia capillaris 30 parts, Crataegus pinnatifida 15 parts, Astragalus membranaceus 5 parts.

[0061] (II) Administration: Soak the above-mentioned Chinese medicinal materials in water, decoct twice, combine the filtrates and concentrate to 2-3 times the original volume, and take orally twice a day, morning and evening. One course of treatment is 14 days. Mild to moderate cases usually improve after 1-2 courses of treatment, while severe cases require 4-6 courses of treatment for significant improvement.

[0062] III. Evaluation of Therapeutic Effect

[0063] Both pre-treatment and post-treatment scores were expressed as GAGS scores, and the nimodipine method was used to evaluate efficacy.

[0064] The efficacy index = [(pre-treatment score - post-treatment score) ÷ pre-treatment score] × 100%.

[0065] Cure: All skin lesions have disappeared, with a cure rate ≥90%;

[0066] Significant effect: Most skin lesions subsided, with an efficacy index ≥60% but <90%;

[0067] Effective: Partial resolution of skin lesions, efficacy index ≥30% but <60%;

[0068] Ineffective: Skin lesions do not improve significantly, and the efficacy index is <30%.

[0069] Overall clinical effective rate = (cured + significantly effective + effective) / total number of cases × 100%

[0070] Cure rate = (Cure + Significant improvement) / Total number of cases × 100%

[0071] IV. Treatment Effects

[0072] The table below shows the statistical results of treatment:

[0073]

[0074] The above statistical data shows that the traditional Chinese medicine for treating acne of the present invention has a good therapeutic effect on acne, including 5 cases cured, 34 cases with significant effect, 3 cases with effect, and 0 cases without effect, with a total significant cure rate of 92.9%.

[0075] The above description is merely an illustrative example of how the present invention can be implemented, and is not intended to cover the scope of protection of the present invention. Any modifications or additions made by those skilled in the art to the specific embodiments described, or any substitutions made in a similar manner, as long as they do not deviate from the structure of the invention or exceed the scope defined in the claims, shall fall within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine decoction for treating acne, characterized in that, It is made from the following raw materials in parts by weight: honeysuckle 20-30 parts (or dandelion can be used instead), forsythia 20-30 parts, licorice 3-6 parts, scorpion 1-3 parts, prunella vulgaris 5-10 parts, salvia miltiorrhiza 10-30 parts, gleditsia sinensis thorn 5-10 parts, artemisia capillaris 20-30 parts, hawthorn 10-15 parts, and astragalus membranaceus 5-10 parts.

2. The traditional Chinese medicine decoction as described in claim 1, characterized in that, The raw materials are in the following proportions by weight: honeysuckle 25-30 parts (or dandelion can be used instead), forsythia 25-30 parts, licorice 3-5 parts, scorpion 1 part, prunella vulgaris 5-10 parts, salvia miltiorrhiza 15-30 parts, gleditsia sinensis thorn 10 parts, artemisia capillaris 30 parts, hawthorn 10-15 parts, and astragalus membranaceus 5-10 parts.

3. The traditional Chinese medicine decoction as described in claim 1, characterized in that, The raw materials are in the following proportions by weight: 30 parts honeysuckle (or dandelion can be used instead), 30 parts forsythia, 5 parts licorice, 1 part scorpion, 10 parts prunella vulgaris, 20 parts salvia miltiorrhiza, 10 parts gleditsia sinensis, 30 parts artemisia capillaris, 15 parts hawthorn, and 5 parts astragalus membranaceus.

4. The method for preparing the traditional Chinese medicine decoction according to any one of claims 1-3, characterized in that, Includes the following steps: Soaking, double boiling, filtrate merging and concentration.

5. The preparation method according to claim 4, characterized in that, For the first decoction, add 8-10 times the total weight of the herbs and decoct for 30-40 minutes; for the second decoction, add 6-8 times the total weight of the dregs and decoct for 20-30 minutes.

6. The use of a traditional Chinese medicine decoction as described in any one of claims 1-3 in the preparation of a drug for treating acne.

7. The use as described in claim 6, characterized in that, The drug is an oral liquid, granules, or capsule.

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