Fluid filter cartridge assembly

Abstract

The invention discloses a cartridge assembly. The cartridge assembly comprises an inlet cartridge plate, an outlet cartridge plate and a separation layer arranged between the inlet cartridge plate and the outlet cartridge plate. The inlet cassette plate defines an inlet flow path and an inlet channel extending therefrom. The outlet cassette plate is configured in a stacked arrangement with the inlet cassette plate and defines an outlet flow path and an outlet channel extending therefrom. The separation layer extends from a first lateral end to a second lateral end. The inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer. The inlet channel defines an effective inlet surface area of the separation layer, and the outlet channel defines an effective outlet surface area of the separation layer. The effective inlet surface area defines a first width toward the first lateral end and a second width toward the second lateral end.

Description

Related applications

[0001] This application claims priority to U.S. Provisional Patent Application No. 63 / 456,282, filed March 31, 2023, entitled Fluid Filtering Cassette Assembly, under 35 U.S. SC §119(e), which is incorporated herein by reference in its entirety. Technical Field

[0002] This invention generally relates to filter cartridge assemblies. More specifically, this invention relates to a fluid filter cartridge including at least one of a flow guide, an optimized fluid inlet geometry, and an inlet retention feature. Background Technology

[0003] Fluid filter cartridges can be used in applications such as membrane chromatography, tangential flow filtration (TFF), and various microfiltration applications. As the fluid flows from the inlet and through the cartridge to the outlet, various forces and pressures may act on the fluid and the cartridge.

[0004] It may be desirable to promote a uniform fluid flow that laterally crosses a first side of the separator layer disposed within the cartridge assembly, axially passes through the separator layer, and then laterally crosses the opposite side of the separator layer once the fluid has passed through it. This uniform flow improves fluid filtration. Uniform flow may also result in more consistent and easier-to-control pressure within the cartridge assembly. Therefore, the fluid filter cartridge assembly may have an inlet channel that carries the fluid to the separator layer in a manner that promotes uniform flow.

[0005] It may also be desirable to remove gas from the cartridge assembly to promote consistent pressure and fluid flow during filtration. Summary of the Invention

[0006] The technology disclosed herein relates to a fluid filter cartridge assembly having at least one of the following: a flow guide, an optimized fluid inlet geometry, and an inlet retention feature. Any or more of the above features allow the fluid filtration to be optimized or adapted to various operating conditions and environments.

[0007] In one or more embodiments, the cassette assembly includes an inlet cassette plate. The inlet cassette plate defines an inlet flow path and an inlet channel extending from the inlet flow path. The cassette assembly also includes an outlet cassette plate. The outlet cassette plate is configured to stack with the inlet cassette plate. The outlet cassette plate defines an outlet flow path and an outlet channel extending from the outlet flow path. The cassette assembly further includes a separation layer disposed between the inlet cassette plate and the outlet cassette plate. The separation layer extends from a first lateral end to a second lateral end. The inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form an assembly flow path. The inlet channel defines an effective inlet surface area of ​​the separation layer. The outlet channel defines an effective outlet surface area of ​​the separation layer. The effective inlet surface area defines a first width toward the first lateral end and a second width toward the second lateral end. The first width is smaller than the second width.

[0008] Alternatively, the inlet channel extends from an inlet midpoint between the first and second lateral ends toward the second lateral end. Alternatively, the outlet channel extends from an outlet midpoint between the first and second lateral ends toward the first lateral end. Alternatively, the width of the effective inlet surface area gradually narrows from a first width to a second width. Alternatively, the box assembly includes a flow guide positioned within the inlet channel toward the first lateral end. The flow guide defines a first width. Alternatively, the flow guide gradually narrows from the first width to the second width. Alternatively, the inlet box plate defines a second width.

[0009] Alternatively, the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel. The inlet opening defines an elongated slit spanning a first width. Alternatively, the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel. The inlet opening is circular. Alternatively, the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel. The outlet opening defines an elongated slit spanning a first width. Alternatively, the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel. The outlet opening is circular.

[0010] Alternatively, the cartridge assembly includes a component inlet. An inlet flow path defines an axial through-hole. An inlet cartridge plate is configured to fluidly couple the component inlet and the inlet channel. Alternatively, the cartridge assembly further includes a component outlet. An outlet flow path defines an axial through-hole. An outlet cartridge plate is configured to fluidly couple the component outlet and the outlet channel.

[0011] Alternatively, the box assembly includes an inlet retaining feature configured to cover an inlet opening of the inlet flow path. The inlet opening defines an interface between the inlet flow path and the inlet channel. Alternatively, the box assembly includes an outlet retaining feature configured to cover an outlet opening of the outlet flow path. The outlet opening defines an interface between the outlet flow path and the outlet channel.

[0012] Alternatively, the cartridge assembly includes a separation layer seal mounted between the inlet and outlet cartridge plates. The separation layer seal contacts both the inlet and outlet cartridge plates. The separation layer seal is configured to fluidly seal the peripheral regions of the separation layer, the inlet passage, and the outlet passage. Alternatively, the separation layer seal includes an overmolded gasket.

[0013] Alternatively or alternatively, the separation layer comprises a membrane stack, which further comprises a plurality of membrane layers. The plurality of membrane layers comprises at least 10 membrane layers. Alternatively or alternatively, the separation layer has an effective inlet surface region defined by an effective length and an effective width. The effective length is at least 2.5 times the effective width.

[0014] Alternatively, the cartridge assembly includes an outlet channel spacer positioned in an outlet channel. The outlet channel spacer is configured to receive fluid flow. Alternatively, the cartridge assembly includes an inlet channel spacer positioned in an inlet channel. The inlet channel spacer is configured to receive fluid flow. Alternatively, at least one of the inlet channel spacer and the outlet channel spacer includes a lateral ridge extending across the separation layer.

[0015] Alternatively, the outlet box panel includes an alignment feature, and the inlet box panel includes a mating alignment feature. The alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box panel and the inlet box panel.

[0016] Alternatively, the cassette assembly includes fasteners configured to operatively couple the inlet cassette plate and the outlet cassette plate. Alternatively, the fasteners include bolts. The inlet cassette plate defines a first axial through-hole, and the outlet cassette plate defines a second axial through-hole. The first and second axial through-holes are configured to be laterally aligned to receive the bolt. The cassette assembly further includes a first nut configured to receive one end of the bolt and a second nut configured to receive the opposite end of the bolt. The first and second nuts are configured to apply a compressive force to the cassette assembly.

[0017] Alternatively, the box assembly may include an attachment seal between the inlet box plate and the outlet box plate. The attachment seal extends laterally around the periphery of the separation layer and externally.

[0018] In one or more embodiments, the cassette assembly includes an inlet cassette plate. The inlet cassette plate defines an inlet flow path, an inlet channel in fluid communication with the inlet flow path, and an inlet opening. The inlet opening defines an interface between the inlet flow path and the inlet channel. The cassette assembly includes an outlet cassette plate configured to be stacked with the inlet cassette plate. The outlet cassette plate defines an outlet flow path and an outlet channel in fluid communication with the outlet flow path. The cassette assembly includes a separation layer disposed between the inlet cassette plate and the outlet cassette plate. The separation layer extends from a first lateral end to a second lateral end. The inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form an assembly flow path. The cassette assembly includes an inlet retaining feature extending across the inlet opening of the inlet flow path.

[0019] Alternatively, the inlet channel extends from the midpoint of the inlet between the first and second lateral ends toward the second lateral end. Alternatively, the outlet channel extends from the midpoint of the outlet between the first and second lateral ends toward the first lateral end. Alternatively, the width of the effective inlet surface area gradually narrows from a first width to a second width.

[0020] Alternatively, the box assembly includes a flow guide positioned within the inlet channel toward a first lateral end. The flow guide defines a first width. Alternatively, the flow guide gradually narrows from the first width to a second width. Alternatively, the inlet box plate defines a second width.

[0021] Alternatively, the inlet flow path has an inlet opening. The inlet opening defines an interface between the inlet flow path and the inlet channel. The inlet opening defines an elongated slit spanning a first width. Alternatively, the inlet flow path has an inlet opening defining the interface between the inlet flow path and the inlet channel, and the inlet opening is circular. Alternatively, the outlet flow path has an outlet opening. The outlet opening defines an interface between the outlet flow path and the outlet channel. The outlet opening defines an elongated slit spanning a first width. Alternatively, the outlet flow path has an outlet opening defining the interface between the outlet flow path and the outlet channel, and the outlet opening is circular.

[0022] Alternatively, the cartridge assembly includes a component inlet. An inlet flow path defines an axial through-hole. An inlet cartridge plate is configured to fluidly couple the component inlet and the inlet channel. Alternatively, the cartridge assembly includes a component outlet. An outlet flow path defines an axial through-hole. An outlet cartridge plate is configured to fluidly couple the component outlet and the outlet channel. Alternatively, the cartridge assembly includes an outlet retaining feature configured to cover an outlet opening of the outlet flow path. The outlet opening defines an interface between the outlet flow path and the outlet channel.

[0023] Alternatively, the cartridge assembly includes a separation layer seal mounted between the inlet cartridge plate and the outlet cartridge plate. The separation layer seal contacts the inlet and outlet cartridge plates. The separation layer seal is configured to fluidly seal the peripheral regions of the separation layer, the peripheral regions of the inlet passage, and the peripheral regions of the outlet passage. Alternatively, the separation layer seal includes an overmolded gasket. Alternatively, the separation layer includes a membrane stack. The membrane stack further includes multiple membrane layers. The multiple membrane layers include at least 10 membrane layers.

[0024] Alternatively, the separation layer may have an effective inlet surface area defined by an effective length and an effective width. The effective length is at least 2.5 times the effective width.

[0025] Alternatively, the cartridge assembly includes an outlet channel spacer positioned in an outlet channel. The outlet channel spacer is configured to receive fluid flow. Alternatively, the cartridge assembly includes an inlet channel spacer positioned in an inlet channel. The inlet channel spacer is configured to receive fluid flow. Alternatively, at least one of the inlet channel spacer and the outlet channel spacer includes a lateral ridge extending across the separation layer.

[0026] Alternatively, the outlet box panel includes an alignment feature, and the inlet box panel includes a mating alignment feature. The alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box panel and the inlet box panel.

[0027] Alternatively, the cassette assembly includes fasteners configured to operatively couple the inlet cassette plate and the outlet cassette plate. Alternatively, the fasteners include bolts. The inlet cassette plate defines a first axial through-hole. The outlet cassette plate defines a second axial through-hole. The first and second axial through-holes are configured to be laterally aligned to receive the bolt. The cassette assembly further includes a first nut configured to receive one end of the bolt and a second nut configured to receive the opposite end of the bolt. The first and second nuts are configured to apply a compressive force to the cassette assembly.

[0028] Alternatively, the box assembly may include an attachment seal between the inlet box plate and the outlet box plate. The attachment seal extends laterally around the periphery of the separation layer and externally.

[0029] In one or more embodiments, the cassette assembly includes an inlet cassette plate. The inlet cassette plate defines an inlet flow path, an inlet channel in fluid communication with the inlet flow path, and an inlet opening. The inlet opening defines an interface between the inlet flow path and the inlet channel. The inlet opening is an elongated slit. The cassette assembly includes an outlet cassette plate configured to stack with the inlet cassette plate. The outlet cassette plate defines an outlet flow path, an outlet channel in fluid communication with the outlet flow path, and an outlet opening. The outlet opening defines an interface between the outlet flow path and the outlet channel. The cassette assembly includes a separation layer. The separation layer is disposed between the inlet cassette plate and the outlet cassette plate and extends from a first lateral end to a second lateral end. The inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form an assembly flow path. The inlet channel defines an effective inlet surface area of ​​the separation layer. The outlet channel defines an effective outlet surface area of ​​the separation layer. The inlet opening extends laterally along the width of the effective inlet surface area.

[0030] Alternatively, the inlet channel extends from the midpoint of the inlet between the first and second lateral ends toward the second lateral end. Alternatively, the outlet channel extends from the midpoint of the outlet between the first and second lateral ends toward the first lateral end. Alternatively, the width of the effective inlet surface area gradually narrows from a first width to a second width.

[0031] Alternatively, the box assembly includes a flow guide positioned within the inlet channel toward a first lateral end. The flow guide defines a first width. Alternatively, the flow guide gradually narrows from the first width to a second width. Alternatively, the inlet box plate defines a second width.

[0032] Alternatively, the outlet flow path has an outlet opening. The outlet opening defines the interface between the outlet flow path and the outlet channel. The outlet opening defines an elongated slit spanning a first width. Alternatively, the outlet flow path has an outlet opening defining the interface between the outlet flow path and the outlet channel, and the outlet opening is circular.

[0033] Alternatively, the cartridge assembly includes a component inlet. An inlet flow path defines an axial through-hole. An inlet cartridge plate is configured to fluidly couple the component inlet and the inlet channel. Alternatively, the cartridge assembly includes a component outlet. An outlet flow path defines an axial through-hole. An outlet cartridge plate is configured to fluidly couple the component outlet and the outlet channel.

[0034] Alternatively, the box assembly includes an inlet retaining feature. The inlet retaining feature is configured to cover an inlet opening in the inlet flow path. The inlet opening defines an interface between the inlet flow path and the inlet channel. Alternatively, the box assembly includes an outlet retaining feature. The outlet retaining feature is configured to cover an outlet opening in the outlet flow path. The outlet opening defines an interface between the outlet flow path and the outlet channel.

[0035] Alternatively, the cartridge assembly includes a separation layer seal mounted between the inlet cartridge plate and the outlet cartridge plate. The separation layer seal contacts both the inlet and outlet cartridge plates. The separation layer seal is configured to fluidly seal the peripheral regions of the separation layer, the inlet passage, and the outlet passage. Alternatively, the separation layer seal includes an overmolded gasket.

[0036] Alternatively, the separation layer may comprise a membrane stack, which may further comprise a plurality of membrane layers. The plurality of membrane layers may comprise at least 10 membrane layers.

[0037] Alternatively, the separation layer may have an effective inlet surface area defined by an effective length and an effective width. The effective length is at least 2.5 times the effective width.

[0038] Alternatively, the cartridge assembly includes an outlet channel spacer positioned in an outlet channel. The outlet channel spacer is configured to receive fluid flow. Alternatively, the cartridge assembly includes an inlet channel spacer positioned in an inlet channel. The inlet channel spacer is configured to receive fluid flow. Alternatively, at least one of the inlet channel spacer and the outlet channel spacer includes a lateral ridge extending across the separation layer.

[0039] Alternatively, the outlet box panel includes an alignment feature, and the inlet box panel includes a mating alignment feature. The alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box panel and the inlet box panel.

[0040] Alternatively, the cassette assembly includes fasteners configured to operatively couple the inlet cassette plate and the outlet cassette plate. Alternatively, the fasteners include bolts. The inlet cassette plate defines a first axial through-hole. The outlet cassette plate defines a second axial through-hole. The first and second axial through-holes are configured to be laterally aligned to receive the bolt. The cassette assembly further includes a first nut configured to receive one end of the bolt and a second nut configured to receive the opposite end of the bolt. The first and second nuts are configured to apply a compressive force to the cassette assembly.

[0041] Alternatively, the box assembly may include an attachment seal between the inlet box plate and the outlet box plate. The attachment seal extends laterally around the periphery of the separation layer and externally.

[0042] The above description is not intended to depict every embodiment or every implementation. Rather, a more complete understanding of the illustrative embodiments will become apparent and understood in light of the accompanying drawings, the following detailed description, and the claims. Attached Figure Description

[0043] Figure 1 This is a first perspective view of an example fluid filter cartridge assembly consistent with different embodiments.

[0044] Figure 2 Is with Figure 1 The example is a consistent exploded perspective view.

[0045] Figure 3 Is with Figures 1-2 Another exploded perspective view consistent with the example.

[0046] Figure 4 Is with Figures 1-3 The example is a consistent perspective cross-sectional view.

[0047] Figure 5 Is with Figures 1-4 The example shows a detailed view of a cross-section of a portion of a consistent box component.

[0048] Figure 6 This is a first perspective view of an example fluid filter cartridge assembly consistent with different embodiments.

[0049] Figure 7 Is with Figure 5 The example is a consistent perspective cross-sectional view.

[0050] Figure 8 Is with Figures 5-6 Another perspective cross-sectional view consistent with the example.

[0051] Figure 9 This is a face view of an example channel spacer that is consistent with some examples.

[0052] Figure 10 It is a partial exploded view of the example box component that is consistent with some examples.

[0053] The invention can be more fully understood and appreciated by considering the following detailed description of various embodiments in conjunction with the accompanying drawings.

[0054] The accompanying drawings are reproduced primarily for clarity, and therefore, they are not necessarily drawn to scale. Furthermore, various structures / components, including but not limited to fasteners, electrical components (wiring, cables, etc.), fluid conduits such as pipes, enclosures, etc., may be schematically shown or partially or entirely removed from the views to better illustrate aspects of the depicted embodiments, or may be included where such structures / components are not essential for understanding the various exemplary embodiments described herein. However, the lack of illustration / description of such structures / components in certain drawings should not be construed as limiting the scope of the various embodiments in any way. Detailed Implementation

[0055] Box components consistent with the techniques disclosed herein can have a variety of different configurations. Figures 1-5 An example embodiment of the box assembly 110 is shown, and Figures 6-8 Another example embodiment of the box assembly 210 is shown. Figures 9-10 The elements shown can be applied to any example embodiment. Figures 1-5 See the description below. The cartridge assembly 110 is generally configured to filter fluid passing through it. The cartridge assembly 110 generally has an inlet cartridge plate 114, an outlet cartridge plate 120, and a separation layer 130. The cartridge assembly 110 may be configured to filter fluid passing through it. This disclosure does not limit the flow direction to any particular orientation.

[0056] like Figures 1-3 As shown, the box assembly 110 has an inlet box panel 114, an outlet box panel 120, and a separation layer 130 disposed between the inlet box panel 114 and the outlet box panel 120. The outlet box panel 120 can be configured to be stacked with the inlet box panel 114.

[0057] Inlet box 114 can limit the inlet flow path 116 (especially in Figure 4 (See image). The inlet flow path 116 can be positioned toward the first lateral end 101 (as can be seen). Figures 2-3 The inlet box panel 114 may limit the inlet box ventilation opening 124. Figure 2 , Figure 4 The inlet flow path 116 defines the inlet fluid flow from component inlet 110a during fluid filtration applications. Figure 1 The path into the inlet box plate 114. The inlet box vent 124 selectively defines the path of gas exiting from the inlet box plate 114 during fluid filtration applications. The inlet box vent 124 may be open or closed to the surrounding environment. The inlet flow path 116 may extend axially through the inlet box plate 114. The inlet box vent 124 may extend axially through the inlet box plate 114.

[0058] The outlet plate 120 of each component box 110 can define the outlet flow path 118. Figure 4The outlet flow path 118 can be positioned toward the second lateral end 103. Figures 2-3 The outlet box plate 120 can limit the outlet box ventilation opening 122. Figures 3-4 The outlet flow path 118 defines the path of the outlet fluid flow from component outlet 110b during fluid filtration applications. The outlet box vent 122 defines the path of gas exhaust from outlet box plate 120 during fluid filtration applications. The outlet flow path 118 may extend axially through outlet box plate 120. The outlet box vent 122 may extend axially through outlet box plate 120. The outlet box vent 122 may be open or closed to the surrounding environment. The inlet flow path 116 may generally be configured for fluid communication with the outlet flow path 118.

[0059] In various embodiments, the inlet flow path 116 and the outlet flow path 118 are in fluid communication via a separation layer 130 of the cartridge assembly 110. The separation layer 130 is disposed between the inlet cartridge plate 114 and the outlet cartridge plate 120. The separation layer 130 may extend from a first lateral end 101 to a second lateral end 103. The separation layer 130 may define a total inlet surface area 104. Figure 2 ) and total outlet surface area 105 ( Figure 3 ).

[0060] Separation layer 130 is generally configured to filter a fluid flow from inlet flow path 116 to outlet flow path 118. The separation layer is configured to separate at least one component of the fluid flow from the fluid flow. Such separation can be achieved through one or more of the following processes as the fluid flows along and / or passes through the separation layer: chemical binding, biomolecular binding, particle capture, absorption, adsorption, etc. The separation layer may comprise a single layer or multiple layers. In some embodiments, separation layer 130 is a fibrous material. In some embodiments, separation layer 130 may be a particulate material. In some embodiments, separation layer 130 is a monolayer membrane. In some embodiments, separation layer 130 is a membrane stack / membrane laminate. A membrane stack / membrane laminate may comprise multiple membranes continuously layered in an axial direction. Inlet flow path 116 may be configured to be in fluid communication with outlet flow path 118 through separation layer 130.

[0061] In embodiments where the separation layer 130 includes a membrane stack, the separation layer 130 may include a plurality of membrane layers 131. Figure 5(As shown in the figure). The plurality of membrane layers 131 can be from 1 to 50 membrane layers 131. In an embodiment, the plurality of membrane layers 131 may include at least 10 membrane layers 131. In alternative embodiments, the plurality of membrane layers 131 may include at least 5, at least 15, at least 19, at least 20, at least 30, at least 40, or at least 50 membrane layers 131, etc. In alternative embodiments, the plurality of membrane layers 131 may include less than 50, less than 45, less than 35, less than 25, less than 17, less than 9, less than 4 membrane layers 131, etc.

[0062] Membrane layer 131 can be composed of various materials and combinations thereof. In various embodiments, membrane layer 131 is incorporated with a breathable membrane, such as polytetrafluoroethylene (PTFE) or other types of breathable membranes. Membrane layer 131 can be a laminate or composite material including a breathable membrane, such as PTFE laminated to a woven or nonwoven support layer. In some embodiments, membrane layer 131 is incorporated with a microporous substrate. In some embodiments, each of membrane layers 131 is composed of the same or similar materials. In some embodiments, one or more of membrane layers 131 are composed of a material different from the other membrane layers 131.

[0063] Figures 3-4 Showing with Figures 1-2 A detailed view of the cross-section of the consistent box assembly 110. The box assembly 110 may further define an inlet channel 136 and an outlet channel 138 (e.g., Figures 2-3 As shown in the diagram). The inlet channel 136 generally defines the flow path from the inlet (116). Figure 3 The fluid flow follows the path of the first lateral surface 134 of the separation layer 130. The outlet channel 138 generally defines the path of the fluid flow along the second lateral surface 135 of the separation layer 130, which is opposite to the first lateral surface 134. The outlet channel 138 extends from the separation layer 130 to the outlet flow path 118. Figure 2 ).

[0064] Inlet channel 136 may extend from inlet flow path 116. Inlet channel 136 may define an effective inlet surface region 132a of separation layer 130. “Effective inlet surface region” 132a is defined as the surface region of the upstream surface of separation layer 130, which is a first transverse surface 134 in fluid communication with inlet channel 136. Effective inlet surface region 132a is partially defined by an effective length L4 ( Figure 3 (as shown in the diagram). Conversely, the total length of the separation layer 130 is defined by L3 ( Figure 2 and Figure 5The difference between L3 and L4 may be a result of features that obstruct fluid flow through the surface separation layer, such as the separation layer seal 146 (discussed further herein) or the structure defined by the housings 114, 120. The inlet channel 136 may extend laterally from the inlet flow path 116. The inlet channel 136 may extend axially between the inlet housing 114 and the effective inlet surface region 132a of the separation layer 130. In some embodiments, the inlet channel 136 may have an axial depth that accommodates the axial expansion of the separation layer 130 caused by fluid flow through it, wherein a portion of the axial depth remains away from the separation layer 130 to accommodate the fluid flow. In embodiments with membrane stacks, for example, the size of the inlet channel 136 may depend on, for example, the number of membrane layers 131, the material of the membrane layers 131, the desired fluid flow rate through the assembly 110, etc.

[0065] The effective inlet surface region 132a may define a first width toward the first lateral end 101. The effective inlet surface region 132a may define a second width toward the second lateral end 103. The inlet box plate 114 may define the first width. The inlet box plate 114 may define the second width. In some embodiments, the first width is smaller than the second width (e.g., Figure 3 (As shown in the diagram). In alternative embodiments (not shown), the first width and the second width may be substantially the same, or the first width may be greater than the second width. In other alternative embodiments, the width of the effective inlet surface region 132a may gradually narrow from the first width to the second width, and vice versa.

[0066] An outlet channel 138 may extend from an outlet flow path 118. The outlet channel 138 may define an effective outlet surface region 132b of the separation layer 130. An “effective outlet surface region” is defined as a surface region of a downstream surface of the separation layer 130, which is a second lateral surface 135 in fluid communication with the outlet channel 138. The outlet channel 138 may extend laterally toward the outlet flow path 118. The outlet channel 138 may be in fluid communication with the outlet flow path 118. The outlet channel 138 may extend axially between the effective outlet surface region 132b of the separation layer 130 and the outlet cassette 120. In some embodiments, the outlet channel 138 may have an axial depth that accommodates axial expansion of the separation layer 130 caused by fluid flow through it, wherein a portion of the axial depth remains away from the separation layer 130 to accommodate the fluid flow. In embodiments with membrane stacks, for example, the size of the outlet channel 138 may depend on, for example, the number of membrane layers 131, the material of the membrane layers 131, the desired fluid flow rate through the assembly 110, etc.

[0067] In some embodiments, inlet channel 136 may be defined by at least one of inlet cassette 114, separation layer 130, effective inlet surface area 132a, and inlet flow path 116. Outlet channel 138 may be defined by at least one of outlet cassette 120, separation layer 130, effective outlet surface area 132b, and outlet flow path 118. In some embodiments, channels 136 and 138 may be defined by any combination of the listed components, and additionally by one or more seals further discussed herein.

[0068] An inlet channel 136 may extend from an inlet intermediate position 139 toward a second lateral end 103. The inlet intermediate position 139 may be located between the first lateral end 101 and the second lateral end 103. An outlet channel 138 may extend from an outlet intermediate position 137 toward the first lateral end 101. The outlet intermediate position 137 may be located between the first lateral end 101 and the second lateral end 103.

[0069] Inlet box 114 can further define inlet guide 190 ( Figure 3 The inlet deflector 190 can advantageously reduce or prevent backflow. Therefore, the inlet deflector 190 can advantageously improve the uniformity of fluid flow across the entire effective region of the separation layer 130. The inlet deflector 190 can be positioned within the inlet channel 136 at a first lateral end 101. The inlet deflector 190 can define a first width. The inlet deflector 190 can gradually narrow from the first width to a second width, and vice versa.

[0070] The inlet deflector 190 can be configured to fluidly seal the inlet reflux region 192 of the inlet box plate 114. The inlet reflux region 192 may include the space / volume of an inlet passage (discussed further herein) extending laterally outward from the inlet flow path 116. The inlet deflector 190 may be a chamfered wall or body ( Figure 3 ), its fluid-sealed inlet reflux zone 192 is separated from the effective inlet surface area. Figure 3 ).

[0071] The outlet box plate 120 may further define the outlet guide 194. The outlet box plate 120 may define a first width. The outlet box plate 120 may define a second width. The outlet guide 194 may advantageously reduce or prevent backflow mixing, wherein once the fluid has passed through the separation layer 130, the fluid in the box will not flow laterally across the opposite side of the separation layer 130. Therefore, the outlet guide 194 may advantageously improve the uniformity of fluid flow across the entire effective area of ​​the separation layer 130. The outlet guide 194 may be positioned within the outlet channel 138 at a second lateral end 103. The outlet guide 194 may define a second width. The outlet guide 194 may gradually narrow from the first width to the second width, and vice versa.

[0072] The outlet deflector 194 can be configured to fluidly seal the outlet recirculation zone 196 of the outlet box plate 120. The outlet recirculation zone 196 may include the space / volume of an outlet passage (discussed further herein) extending laterally outward from the outlet flow path 118. The outlet deflector 194 may be a chamfered wall or body (not shown) that fluidly seals the outlet recirculation zone 196 separated from the effective outlet surface area. Figure 2 ).

[0073] The cassette assembly 110 may further include a component inlet 110a and a component outlet 110b. The inlet cassette plate 114 may be configured to fluidly couple the component inlet 110a and the inlet channel 136. The outlet cassette plate 120 may be configured to fluidly couple the component outlet 110b and the outlet channel 138.

[0074] The box assembly 110 may further include an inlet flow path extension 117 (e.g., 117a, 117b) and an outlet flow path extension 125 (e.g., 125a, 125b), such as Figure 4 As shown in the diagram. These extensions are configured to fluidly couple the inlet flow path and the outlet flow path to the inlet channel and the outlet channel, respectively. The inlet flow path extension 117 may be defined by the inlet housing plate 114. The inlet flow path extension 117 may be configured to fluidly couple the inlet flow path 116 and the inlet channel 136. The inlet flow path extension 117 may include a first portion 117a and a second portion 117b (see...). Figure 4 The first portion 117a may extend laterally from the inlet flow path 116 toward the inlet channel 136. In the current example, the second portion 117b extends axially from the first portion 117a toward the inlet channel 136. The second portion 117b may be in fluid communication with the inlet channel 136 toward one lateral end of the inlet channel. In some embodiments, the second portion 117b may be in fluid communication with the inlet channel 136 at one lateral end of the inlet channel 136.

[0075] The outlet flow path extension 125 may be defined by the outlet box plate 120. The outlet flow path extension 125 may fluidly couple the outlet flow path 118 and the outlet channel 138. Figure 4 The outlet flow path extension 125 may include a first portion 125a and a second portion 125b. The first portion 125a may extend axially from the outlet channel 138 to the second portion 125b. The second portion 125b may extend laterally from the first portion 125a to the outlet flow path 118. The first portion 125a may extend toward the effective length L4 of the separation layer 130. Figure 5 As shown, the opposite end of the first portion 117a of the inlet extension is fluidly coupled to the outlet channel 138.

[0076] In alternative embodiments, the extension does not define a 90-degree segment relative to each other or to the corresponding fluid flow paths as shown, but may define one or more curved segments. In a further alternative embodiment, the inlet extension is a single segment extending at an angle from the inlet flow path 116 to the inlet channel 136 such that the inlet extension is not orthogonal to the inlet flow path 116 or the inlet channel 136. Similarly, the outlet extension 125 may define one or more segments, wherein at least one segment is curved. In some embodiments, the outlet extension is a single segment defining an angle and extending at an angle from the outlet channel 138 to the outlet flow path 118 such that the outlet extension is not orthogonal to the outlet flow path 118 or the outlet channel 138.

[0077] Part 117b may extend along the width W1 of the entrance channel 136 (e.g.) Figure 3 As shown in the diagram, at least a portion of the first portion 125a extends laterally. This can advantageously improve the uniformity of fluid flow across the entire effective region of the separation layer 130. Similarly, in this example, the first portion 125a may extend laterally along the width W2 of the outlet channel 138 (as shown in the diagram). Figure 2 At least a portion of the lateral extension (as shown in the diagram) extends across the entire effective region of the separation layer 130. Such a configuration can advantageously improve the uniformity of fluid flow across the entire effective region of the separation layer 130. Alternative examples are possible in which one or both of the second portion 117b of the inlet flow path extension and the first portion 125a of the outlet flow path extension define an opening having a circular shape rather than an elongated slit.

[0078] The shapes of the openings in the second portion 117b of the inlet flow path extension and the first portion 125a of the outlet flow path extension can be optimized for specific fluid filtration applications. The inlet flow path 116 can define an inlet opening 151 into the inlet channel 136. Figure 3Inlet opening 151 defines the interface between inlet flow path 116 and inlet channel 136. The geometry of inlet opening 151 can be any shape (e.g., circular, oval, square, rectangular, hexagonal, elongated slit, etc.) that effectively allows fluid flow through cartridge assembly 110. The geometry of inlet opening 151 can be optimized to advantageously improve fluid flow uniformity across the entire effective area of ​​separation layer 130. Inlet opening 151 may define an elongated slit along a first width. Inlet opening 151 may extend laterally along the width of effective inlet surface region 132a. Inlet opening 151 may be circular. Preliminary testing suggests that using an elongated slit geometry instead of a circular orifice geometry in some embodiments results in better flow distribution and flow uniformity across the entire effective surface region of separation layer 130, at least because the elongated slit provides better fluid mixing and lower pressure within cartridge assembly 110. However, using a smaller geometry can advantageously result in a smaller overall volume of fluid within cartridge assembly 110. Therefore, the geometry can be optimized for the fluid filtration application at hand.

[0079] The exit flow path 118 can limit the exit opening 153 of the exit channel 138. Figure 2 The outlet opening 153 defines the interface between the outlet flow path 118 and the outlet channel 138. The geometry of the outlet opening 153 can be any shape that effectively allows fluid flow through the cartridge assembly 110 (e.g., circular, oval, square, rectangular, hexagonal, elongated slit, etc.). The outlet opening 153 may define an elongated slit along a second width. The outlet opening 153 may extend laterally along the width of the effective outlet surface region 132b. The outlet opening 153 may be circular. The geometry of the outlet opening 153 can be optimized to advantageously improve fluid flow uniformity across the entire effective region of the separation layer 130. Preliminary testing indicates that using an elongated slit geometry instead of a circular orifice geometry in some embodiments results in better flow distribution and flow uniformity across the entire effective surface region of the separation layer 130, at least because the elongated slit provides better fluid mixing and lower pressure within the cartridge assembly 110. However, using a smaller geometry can advantageously result in a smaller overall volume of fluid within the cartridge assembly 110. Therefore, the geometry can be optimized for the fluid filtration application at hand.

[0080] The inlet tray 114 and the outlet tray 120 can be constructed from various materials and combinations thereof. In some embodiments, one or both of trays 114 and 120 are plastic. In other embodiments, one or both of trays 114 and 120 are metal. In one example, one or both of trays 114 and 120 are injection molded, 3D printed, machined, or a combination thereof. In some embodiments, the inlet tray 114 is constructed from the same material as the outlet tray 120. In some other embodiments, the inlet tray 114 is constructed from a different material than the outlet tray 120.

[0081] Figure 9 A lateral view of an example channel spacer is shown, which can be inserted into an inlet channel 136 and / or an outlet channel 138 to ensure, for example, that a separator layer 130 does not expand into the channel and obstruct it. The cassette assembly 110 may further include one or more channel spacers 140, 142, each configured to be received by an inlet channel 136 and / or an outlet channel 138. In the current example, the cassette assembly 110 has an inlet channel spacer 140 and an outlet channel spacer 142 (e.g., ...). Figure 2 and Figure 6 (As shown in the diagram). The inlet channel spacer 140 is generally configured to maintain a minimum axial depth of the inlet channel 136 to sustain fluid flow along the inlet channel 136. As mentioned above, the axial depth of the inlet channel 136 may decrease during system use, for example, due to expansion of the separator layer, and the inlet channel spacer 140 advantageously resists such expansion. The inlet channel spacer 140 may be positioned within the inlet channel 136. The inlet channel spacer 140 is positioned between the inlet cassette 114 and the separator layer 130. In some embodiments, the inlet channel spacer 140 abuts the inlet cassette 114 and the separator layer 130.

[0082] The cartridge assembly 110 may further include an outlet channel spacer 142. The outlet channel spacer 142 is generally configured to maintain a minimum axial depth of the outlet channel 138 to accommodate fluid flow along the outlet channel 138. The axial depth of the outlet channel 138 may decrease during system use due to expansion of the separation layer, and the outlet channel spacer 142 can advantageously resist such expansion. The outlet channel spacer 142 may be positioned within the outlet channel 138. The outlet channel spacer 142 is positioned between the outlet cartridge plate 120 and the separation layer 130. In some embodiments, the outlet channel spacer 142 abuts the outlet cartridge plate 120 and the separation layer 130.

[0083] The inlet channel spacer 140 and / or outlet channel spacer 142 can be constructed from a variety of different materials and combinations thereof. In some embodiments, spacers 140, 142 are plastic. The spacers can be woven or nonwoven materials, such as loosely woven fabric layers. In other embodiments, spacers 140, 142 are metal. In one example, spacers 140, 142 are injection molded, 3D printed, etc. Spacers 140, 142 can be made of elastic materials, such as rubber, polysiloxane (silicone), polyurethane, or other elastic materials. Spacers 140, 142 can be held in place by friction and / or compressive forces. Such friction can occur, for example, between spacers 140, 142 and the separation layer 130, and between spacers 140, 142 and the corresponding cassette plates 114, 120.

[0084] Channel spacers 140, 142 generally define lateral and axial openings to accommodate fluid flow through channel spacers 140, 142 to separation layer 130. In some embodiments, at least one of the inlet channel spacer 140 and the outlet channel spacer 142 may include a lateral ridge 144 extending across separation layer 130, one example of which is... Figure 8 As shown in the diagram. The transverse ridge 144 is generally configured to define a structure to maintain the axial depth of the corresponding channel for fluid flow. The transverse ridge 144 can advantageously provide rigidity to the corresponding spacer. The transverse ridge 144 can further advantageously guide the fluid flow across the corresponding surface area of ​​the separation layer 130.

[0085] The transverse ridge 144 may extend laterally along at least a portion of the channel length of the corresponding channel in which the spacer is located. The transverse ridge 144 may extend axially between the separation layer 130 and the adjacent box plate.

[0086] In some embodiments, the box assembly 110 includes at least one of an inlet retaining feature 150 and an outlet retaining feature 152, such as Figures 2-3As shown in the diagram. Inlet retaining feature 150 and outlet retaining feature 152 advantageously prevent the separation layer 130 from deforming into the inlet flow path 116 and outlet flow path 118, respectively. Inlet retaining feature 150 and outlet retaining feature 152 may not be configured to cover as many inlet flow paths 116 and outlet flow paths 118 as possible, compared to one or more channel spacers 140, 142 that may be configured to cover more of the inlet flow paths 116 and outlet flow paths 118, respectively. In some embodiments, cassette assembly 110 may include one or more channel spacers 140, 142 and one or more retaining features 150, 152. In alternative embodiments, cassette assembly 110 may include only channel spacers 140, 142 without retaining features 150, 152. In further alternative embodiments, cassette assembly 110 may include only retaining features 150, 152 without channel spacers 140, 142. Channel spacers 140, 142 may not, to an optimized degree, prevent such deformation of the separation layer 130, but may advantageously provide flow distribution. In embodiments having both channel spacers 140, 142 and retaining features 150, 152, the channel spacers 140, 142 may be laterally aligned or overlapped with the retaining features 150, 152, or may not be laterally aligned or overlapped with the retaining features 150, 152.

[0087] The inlet retaining feature 150 may be configured to cover the inlet opening 151 of the inlet flow path 116. The inlet retaining feature 150 may extend across the inlet opening 151 of the inlet flow path 116. The inlet opening 151 of the inlet flow path 116 may define an interface between the inlet flow path 116 and the inlet channel 136. The interface may be two-dimensional and may additionally be planar or may not be planar. For example, in some embodiments (and as shown), the interface may be substantially planar and may be substantially parallel to the separation layer 130. In alternative embodiments (not shown), the interface may be non-planar.

[0088] The outlet retaining feature 152 may be configured to cover the outlet opening 153 of the outlet flow path 118. The outlet retaining feature 152 may extend across the outlet opening 153 of the outlet flow path 118. The outlet opening 153 of the outlet flow path 118 may define an interface between the outlet flow path 118 and the outlet channel 138. The interface may be two-dimensional and may additionally be planar or may not be planar. For example, in some embodiments (and as shown), the interface may be substantially planar and substantially parallel to the separation layer 130. In alternative embodiments (not shown), the interface may be non-planar.

[0089] Preliminary tests indicate that, in some implementations, the use of both inlet retaining feature 150 and outlet retaining feature 152 results in better flow distribution and flow uniformity across the entire effective surface area of ​​separation layer 130, and allows the flow direction to be reversed at any time without causing separation layer 130 to undesirably expand into inlet flow path 116 or outlet flow path 118.

[0090] The inlet retaining feature 150 and the outlet retaining feature 152 can be constructed from a variety of different materials and combinations thereof. In some embodiments, one or both of retaining features 150, 152 are plastic and include perforations therethrough for fluid flow. In other embodiments, one or both of retaining features 150, 152 are metal and include perforations therethrough for fluid flow. For example, in one embodiment, the inlet retaining feature 150 and / or the outlet retaining feature 152 may be made of stainless steel. In one example, one or both of retaining features 150, 152 are injection molded, 3D printed, machined, or a combination thereof, and include perforations therethrough for fluid flow. In some embodiments, the inlet retaining feature 150 is constructed from the same material as the outlet retaining feature 152. In some other embodiments, the inlet retaining feature 150 is constructed from a different material than the outlet retaining feature 152.

[0091] The inlet retaining feature 150 and the outlet retaining feature 152 can be attached to the inlet box plate 114 and the outlet box plate 120, respectively, by welding, adhesive, or mechanical attachment. For example, the inlet retaining feature 150 and the outlet retaining feature 152 may include one or more holes around the periphery of the inlet retaining feature 150 and the outlet retaining feature 152, and each hole may be fused to a boss on the respective box plate 114, 120.

[0092] Box assembly 110 may further include a separation layer seal 146. Figures 2-4 , Figure 6 and Figure 7 The separation layer seal 146 is generally configured to seal between the separation layer and each of the inlet box plate 114 and the outlet box plate 120, preventing fluid from escaping between the plates during fluid filtration. The separation layer seal 146 may be installed between the inlet box plate 114 and the outlet box plate 120. In some embodiments, the separation layer seal 146 may contact both the inlet box plate 114 and the outlet box plate 120. The separation layer seal 146 may be configured to fluidly seal the peripheral region 130a of the separation layer 130 (in...). Figure 2 (Partially visible), the surrounding area 136a of the entrance passage 136 ( Figure 3 ) and the surrounding area 138a of the exit passage 138 ( Figure 2In some embodiments, the separation layer seal 146 is defined by a relatively tight coupling of the housing plates 114, 120, which forms a liquid-tight seal via compressive forces around the separation layer 130. In such examples, the separation layer seal, as a component separate from the housing plates 114, 120, may be omitted.

[0093] The release layer seal 146 can be made of a variety of different materials and combinations thereof. In various embodiments, the release layer seal 146 can be made of an elastic material, such as rubber, polysiloxane (silicone), polyurethane, etc. In some other embodiments, the release layer seal 146 is molded plastic. In other embodiments, the release layer seal 146 is metal. In one example, the release layer seal 146 is injection molded, 3D printed, or formed by other types of processes. The release layer seal 146 may include an overmolded gasket. The overmolded gasket may be injection molded around the periphery of the release layer 130 to form the release layer seal 146.

[0094] In an alternative embodiment, the separation layer seal may be more than one seal. Separation layer seal 146 may include a first O-ring inserted between a peripheral region 130a on a first lateral surface 134 (e.g., the upstream surface) of separation layer 130 and the inlet box plate 114. Separation layer seal 146 may include a second O-ring inserted between a peripheral region 130a on a second lateral surface 135 (e.g., the downstream surface) of separation layer 130 and the outlet box plate 120. In a further alternative embodiment, separation layer seal 146 may be, for example, a weld or an adhesive. Welds may be formed between box plates 114 and 120, or between separation layer 130 and the inlet box plate 114, or between separation layer 130 and the outlet box plate 120, or any combination thereof, or adhesives may be used to seal box plates 114 and 120, or between separation layer 130 and the inlet box plate 114, or between separation layer 130 and the outlet box plate 120, or any combination thereof.

[0095] like Figure 5 As shown, in some embodiments, the inlet cassette 114 and the outlet cassette 120 may mutually define a compression structure 147 surrounding the inlet channel 136 and the outlet channel 138. More specifically, in the present example, the outlet cassette 120 defines an axially extending sidewall 147a surrounding the outlet channel 138, which faces the opposing sidewall 147b of the inlet cassette 114 surrounding the inlet channel 136. The axially extending sidewall 147a and the opposing sidewall 147b apply compressive forces on the peripheral region 130a of the separation layer 130, forming a fluid seal. The compression structure 147 advantageously prevents fluid from bypassing it.

[0096] Box assembly 110 may further include attachment seal 158. Figures 2-4 , Figure 6 and Figure 7 The attachment seal 158 is generally configured to provide a fluid seal between the inlet cassette 114 and the outlet cassette 120. The attachment seal 158 can be inserted between the inlet cassette 114 and the outlet cassette 120. The attachment seal 158 can extend laterally around and outside the periphery of the separation layer 130. The attachment seal 158 can be laterally positioned on the respective axial surfaces 115a, 115b of the inlet cassette 114 and the outlet cassette 120. Figure 1 The attachment seal 158 is located between the attachment seal 158 and the separation layer seal 146. The attachment seal 158 may be constructed from various different materials and combinations of materials consistent with those discussed above regarding the attachment seal 146. The attachment seal 158 may be held, for example, by frictional and / or compressive forces, and / or may be held using fasteners 172. Such forces may exist between the attachment seal 158, the inlet cassette 114, and the outlet cassette 120.

[0097] Box components consistent with the techniques disclosed herein can have a variety of different configurations. Figures 6-8 A perspective view of another example box component 210 is shown, and Figures 6-8 This can be viewed in conjunction with the description below. The cartridge assembly 210 is generally configured to filter fluid passing through it. The cartridge assembly 210 generally has an inlet cartridge plate 214, an outlet cartridge plate 220, and a separation layer 230. It should be understood that, unless contradicting the present description or corresponding figures, this description will not be construed herein as... Figures 6-8 The components referenced in the description are consistent with the descriptions of the same components elsewhere in this document.

[0098] Similar to other embodiments described herein, cartridge assembly 210 has an inlet cartridge plate 214, an outlet cartridge plate 220, and a separation layer 230 disposed between the inlet cartridge plate 214 and the outlet cartridge plate 220. The outlet cartridge plate 220 may be configured to stack with the inlet cartridge plate 214. The inlet cartridge plate 214 may define an inlet flow path 216 and an inlet cartridge vent 224. The inlet flow path 216 defines the path through which inlet fluid flows into cartridge assembly 210 during fluid filtration applications. The inlet cartridge vent 224 defines the path through which gas flows out of cartridge assembly 210 during fluid filtration applications. The inlet cartridge vent 224 may be open or closed to the surrounding environment. The inlet flow path 216 may define an axial through-hole extending axially through the inlet cartridge plate 214. The inlet cartridge vent 224 may similarly extend axially through the inlet cartridge plate 214.

[0099] The outlet box plate 220 may define an outlet flow path 218 and an outlet box vent 222. The outlet flow path 218 defines the path of the outlet fluid flow during a fluid filtration application. The outlet box vent 222 defines the path of gas exiting the outlet box plate 220 during a fluid filtration application. The outlet flow path 218 may define an axial through-hole extending axially through the outlet box plate 220. The outlet box vent 222 may similarly extend axially through the outlet box plate 220. The outlet box vent 222 may be open or closed to the surrounding environment. The outlet flow path 218 may generally be configured for fluid communication with the inlet flow path 216.

[0100] In various embodiments, inlet flow path 216 and outlet flow path 218 are in fluid communication via a separation layer 230 of cartridge assembly 210. Separation layer 230 is disposed between inlet cartridge plate 214 and outlet cartridge plate 220. Separation layer 230 is generally configured to filter fluid flow from inlet flow path 216 to outlet flow path 218. Inlet flow path 216 may be configured to be in fluid communication with outlet flow path 218 via separation layer 230. Separation layer 230 may include a membrane stack, which may further include multiple membrane layers, as described herein. Figures 1-5 As stated above.

[0101] Each component box 210 may further include an inlet channel 236 (e.g. Figure 7 (as shown in the diagram) and exit channel 238 (as shown in the diagram) Figure 7 (As shown in the diagram). Inlet channel 236 generally defines the fluid flow from inlet flow path 216 along the first transverse surface 234 of separation layer 230. Figure 7 The path of the fluid flow. The outlet channel 238 generally defines the fluid flow along the second transverse surface 235 of the separation layer 230. Figure 7 The second transverse surface is opposite to the first transverse surface 234. The outlet channel 238 extends from the separation layer 230 to the outlet flow path 218.

[0102] The inlet channel 236 extends along the effective inlet surface region (not shown) of the separation layer 230. The “effective inlet surface region” is defined as the surface region of the upstream surface of the separation layer 230, which is the first transverse surface 234 directly exposed to the inlet channel 236. The inlet channel 236 is similar to the description herein. Figures 1-4 The inlet channel 136 is described above. The outlet channel 238 extends along the effective outlet surface area (not shown) of the separation layer 230. The “effective outlet surface area” is defined as the surface area of ​​the downstream surface of the separation layer 230, which is the second transverse surface 235 exposed to the outlet channel 238. The outlet channel 238 is similar to the description herein. Figures 1-4 The aforementioned exit channel 138.

[0103] The entrance channel 236 of the entrance box plate 214 defines the entrance channel length L1 and the entrance channel width W1, such as Figure 3 As shown in the illustration. In some embodiments, the ratio of the inlet channel length L1 to the inlet channel width W1 can advantageously lead to a relative improvement in flow characteristics during filtration operations. The inlet channel length L1 can be 1 to 4 times the inlet channel width W1. In alternative embodiments, the inlet channel length L1 can be at least 1, at least 1.5, at least 2, at least 2.5, at least 3, at least 3.5, at least 4 times, etc., of the inlet channel width W1, and / or can be less than 4 times, less than 3.75 times, less than 3.25 times, less than 2.75 times, less than 2.25 times, less than 1.75 times, less than 1.25 times, etc., of the inlet channel width W1.

[0104] The outlet channel 238 of the outlet box plate 220 can limit the outlet channel length L2 and the outlet channel width W2, such as Figure 2 As shown in the diagram, the ratio of the exit channel length L2 to the exit channel width W2 can be consistent with the ratio discussed above regarding the inlet channel length L1 and the inlet channel width W1.

[0105] Box assembly 210 may further include component inlet 210a ( Figure 6 ) and component export 210b ( Figure 8 The inlet box 214 can be configured as a fluid coupling assembly inlet 210a and inlet channel 236. The outlet box 220 can be configured as a fluid coupling assembly outlet 210b and outlet channel 238.

[0106] The separation layer 230 generally defines the effective inlet surface area 232a and the effective outlet surface area 232b. Figure 8 The effective inlet surface region 232a has an effective length L4 and an effective width W4. Figure 4 and Figure 5 The effective inlet surface area 232a can be defined as the area of ​​the separation layer 230 that can be used for filtration. The effective inlet surface area 232a is generally smaller than the total surface area of ​​the separation layer 230. The separation layer can be defined with a total length L3. Figure 2 ) and total width W3 ( Figure 2 In the current example, the peripheral area of ​​the separation layer 230 is sandwiched between the inlet box plate 214 and the outlet box plate 220 and cannot be used for filtering, and therefore does not define a portion of the effective area.

[0107] The effective length L4 can be 1 to 4 times the effective width W4. In alternative embodiments, the effective length L4 can be at least 1, at least 1.5, at least 2, at least 2.5, at least 3, at least 3.5, or at least 4 times the effective width W4. In alternative embodiments, the effective length L4 can be less than 4, less than 3.75, less than 3.25, less than 2.75, less than 2.25, less than 1.75, or less than 1.25 times the effective width W4.

[0108] In some embodiments, the effective width W4 is equal to the width of the effective inlet surface region 232a and the width of the effective outlet surface region 232b. In an alternative embodiment, the effective width W4 may differ at the effective inlet surface region 232a from the effective outlet surface region 232b, resulting in an effective inlet width and an effective outlet width (not shown). In some embodiments, the effective length L4 is equal to the length of the effective inlet surface region 232a and the length of the effective outlet surface region 232b. In an alternative embodiment, the effective length L4 of the effective inlet surface region 232a may differ from the effective length of the effective outlet surface region 232b, resulting in an effective inlet length and an effective outlet length (not shown).

[0109] Each component 210 may further include one or more channel spacers, each of which is configured to be received by an inlet channel 236 and / or an outlet channel 238, as per [reference to...]. Figures 1-5 As stated above.

[0110] Each component 210 may further include a separation layer seal 246. Figure 7 The separation layer seal 246 is generally configured to seal between the separation layer and each of the inlet box plate 214 and the outlet box plate 220, preventing fluid from escaping between the plates during fluid filtration. The separation layer seal 246 may be installed between the inlet box plate 214 and the outlet box plate 220. In some embodiments, the separation layer seal 246 may contact the inlet box plate 214 and the outlet box plate 220. The separation layer seal 246 may be configured to fluidly seal the peripheral region of the separation layer 230 (not shown), the peripheral region of the inlet channel 236 (not shown), and the peripheral region of the outlet channel 238 (not shown). The separation layer seal 246 may be similar to... Figures 1-5 The separation layer seal 146.

[0111] The cartridge assembly 210 may further include an attachment seal 258. The attachment seal 258 is generally configured to provide a fluid seal between the inlet cartridge plate 214 and the outlet cartridge plate 220. The attachment seal 258 may be inserted between the inlet cartridge plate 214 and the outlet cartridge plate 220. The attachment seal 258 may extend laterally around the periphery of the separation layer seal 246. The attachment seal 258 may be similar to... Figures 1-5 The attached seal 158.

[0112] Figure 10 This is a schematic exploded view of some components of an alternative example box assembly 310 consistent with the technology disclosed herein. Box assembly 310 has an inlet box plate 314 and an outlet box plate 320. It should be understood that, unless contradicting the present description or corresponding drawings, references to these components herein will vary. Figure 10 The components referenced in the description are consistent with the descriptions of the same components elsewhere in this document.

[0113] The outlet box panel 320 may include an alignment feature 352. The inlet box panel 314 may include a mating alignment feature 354 configured to mate with the alignment feature 352 when the boxes 314 and 320 are properly aligned and stacked. The alignment feature 352 is configured to be laterally aligned with the mating alignment feature 354. "Lateral alignment" herein means that the alignment and mating alignment features overlap in the lateral direction. The lateral direction is defined as any direction orthogonal to the axial direction. The axial direction is parallel to the stacking direction of the inlet box panel 114 and the outlet box panel 120. The alignment feature 352 and the mating alignment feature 354 facilitate operative coupling of the outlet box panel 320 and the inlet box panel 314. The alignment feature 352 and the mating alignment feature 354 advantageously guide the user to correctly stack the various boxes to assemble the box. In some embodiments, the alignment feature 352 may include a protrusion, and the mating alignment feature may include a receiving portion configured to receive the protrusion, but the opposite configuration is also contemplated. In some alternative embodiments, alignment feature 352 may engage with mating alignment feature 354 in a snap-fit ​​configuration. In other alternative embodiments, alignment feature 352 may include a visual indicator, such as a mark configured to align with or away from mating alignment feature 354. In some embodiments, mating alignment feature may be integral with one of the cassette panels 314, 320. In some other embodiments, alignment feature may be a separate component (e.g., a pin, screw, etc.) received by an opening defined by exit cassette panel 320 and inlet cassette panel 314.

[0114] In any of the embodiments described herein but in conjunction with them Figures 1-5As discussed, a syringe, tubing, or other tool can be used to direct fluid to the cartridge assembly 110. Such tools may include mating components, such as a Luer lock, configured to sealably engage one or both of the assembly inlet 110a and the assembly outlet 110b. In alternative embodiments, the assembly inlet 110a and the assembly outlet 110b may be configured to mate with, for example, tubing, syringes, or needles of various sizes. In further alternative embodiments, the assembly inlet 110a and the assembly outlet 110b may be configured to be closable or sealable, and may be further configured to reopen or deseal.

[0115] Box assembly 110 may further include fastener 172 ( Figure 1 Fastener 172 is generally configured to hold components of the housing assembly 110 in an operative configuration. Fastener 172 may be configured to operatively couple inlet housing plate 114 and outlet housing plate 120. In the current example, fastener 172 includes a bolt (not shown). In some embodiments, inlet housing plate 114 may define a first axial through-hole 176 (…). Figure 2 The outlet box plate 120 can define the second axial through hole 178. Figure 2 The first axial through-hole 176 and the second axial through-hole 178 may be configured to be laterally aligned with each other to receive bolts. There may be more than one bolt, and correspondingly, there may be more than one laterally aligned first through-hole 176 and second through-hole 178 to receive more than one bolt. In some embodiments, at least one of the first axial through-hole 176 and the second axial through-hole 178 may include a threaded hole configured to engage a bolt.

[0116] The cassette assembly 110 has fasteners 172 comprising a plurality of bolts, each bolt having a first nut 184 and a second nut (not shown). The first nut 184 may be configured to receive a first end of the bolt. The second nut may be configured to receive an opposing second end of the bolt. The first and second nuts may be configured to apply a compressive force to the cassette assembly 110. The nuts may specifically apply a compressive force to operatively coupled cassette plates 114, 120 via the bolts. The first nut 184 may contact the inlet cassette plate 114, and the second nut may contact the outlet cassette plate 120, or vice versa. Thus, the nuts may apply a compressive force to the cassette plates 114, 120. This may advantageously seal the fluid flow path through the cassette assembly 110. In alternative embodiments, the fasteners 172 may include various clamps, bolts, snap-fits, straps, etc., which may apply the compressive force as described herein.

[0117] In further alternative embodiments, and as Figures 6-8As shown, fastener 272 may include at least one threaded bolt 274, which may threadly engage with at least one threaded hole 276 defined by at least one of inlet box plate 114 and outlet box plate 120. In embodiments where at least one threaded bolt 274 engages with at least one threaded hole 276, at least one of a first nut and a second nut may not be necessary. Due to the threaded engagement between the threaded bolt and the threaded hole, at least one of the first nut and the second nut may not be necessary. Alternatively, only a first nut 284 opposite to one side of the threaded hole 276 is required.

[0118] Back to Figure 8 An inlet box 314 may define a first axial through-hole 376. An outlet box 320 may define a second axial through-hole 378. The first axial through-hole 376 and the second axial through-hole 378 may be configured to be laterally aligned with each other to receive fasteners, such as pins, screws, or bolts (not shown). There may be more than one fastener, and correspondingly, there may be more than one pair of laterally aligned through-holes, each configured to receive a fastener. The fasteners may be configured to operatively couple the inlet box 314 and the outlet box 320. Each of the first axial through-hole and the second axial through-hole may be configured to be laterally aligned with each other to receive a fastener. Exemplary aspects

[0119] Aspect 1. A box assembly comprising: An inlet box plate that defines an inlet flow path and an inlet channel extending from the inlet flow path; An outlet box plate is configured to be stacked with an inlet box plate, and the outlet box plate defines an outlet flow path and an outlet channel extending from the outlet flow path. A separation layer is disposed between the inlet box plate and the outlet box plate and extends from a first lateral end to a second lateral end, wherein the inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form a component flow path. The inlet channel defines an effective inlet surface area of ​​the separation layer and the outlet channel defines an effective outlet surface area of ​​the separation layer, wherein the effective inlet surface area defines a first width toward a first lateral end and a second width toward a second lateral end, and wherein the first width is less than the second width.

[0120] Aspect 2. The box assembly according to any one of Aspects 1 and 3-25, wherein the inlet channel extends from an inlet midpoint between the first lateral end and the second lateral end toward the second lateral end.

[0121] Aspect 3. The box assembly according to any one of Aspects 1-2 and 4-25, wherein the outlet channel extends from an outlet midpoint between the first lateral end and the second lateral end toward the first lateral end.

[0122] Aspect 4. The box assembly according to any one of Aspects 1-3 and 5-25, wherein the width of the effective inlet surface region gradually narrows from a first width to a second width.

[0123] Aspect 5. The box assembly according to any one of Aspects 1-4 and 6-25, further comprising: a flow guide positioned within the inlet channel toward a first lateral end, wherein the flow guide defines a first width.

[0124] Aspect 6. The box assembly according to aspect 5, wherein the flow guide gradually narrows from a first width to a second width.

[0125] Aspect 7. The box assembly according to aspect 5, wherein the inlet box panel defines a second width.

[0126] Aspect 8. The box assembly according to any one of Aspects 1-7 and 9-25, wherein the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel, and wherein the inlet opening defines an elongated slit spanning a first width.

[0127] Aspect 9. The box assembly according to any one of Aspects 1-8 and 10-25, wherein the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel, and wherein the inlet opening is circular.

[0128] Aspect 10. The box assembly according to any one of Aspects 1-9 and 11-25, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening defines an elongated slit spanning a first width.

[0129] Aspect 11. The box assembly according to any one of Aspects 1-10 and 12-25, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening is circular.

[0130] Aspect 12. The box assembly according to any one of Aspects 1-11 and 13-25, further comprising an assembly inlet, wherein an inlet flow path defines an axial through-hole, and wherein an inlet box plate is configured to fluidly couple the assembly inlet and the inlet channel.

[0131] Aspect 13. The box assembly according to any one of Aspects 1-12 and 14-25, further comprising an assembly outlet, wherein an outlet flow path defines an axial through-hole, and wherein an outlet box plate is configured to fluidly couple the assembly outlet and the outlet channel.

[0132] Aspect 14. The box assembly according to any one of Aspects 1-13 and 15-25 further includes an inlet retaining feature configured to cover an inlet opening of the inlet flow path, wherein the inlet opening defines an interface between the inlet flow path and the inlet channel.

[0133] Aspect 15. The box assembly according to any one of Aspects 1-14 and 16-25 further includes an outlet retaining feature configured to cover an outlet opening of the outlet flow path, wherein the outlet opening defines an interface between the outlet flow path and the outlet channel.

[0134] Aspect 16. The box assembly according to any one of Aspects 1-15 and 17-25 further includes a separation layer seal mounted between the inlet box plate and the outlet box plate, wherein the separation layer seal contacts the inlet box plate and the outlet box plate, and wherein the separation layer seal is configured to fluidly seal the peripheral region of the separation layer, the peripheral region of the inlet passage, and the peripheral region of the outlet passage.

[0135] Aspect 17. The box assembly according to any one of Aspects 1-16 and 18-25, wherein the separation layer seal comprises an overmolded gasket.

[0136] Aspect 18. The box assembly according to any one of Aspects 1-17 and 19-25, wherein the separation layer comprises a membrane stack, the membrane stack further comprising a plurality of membrane layers, and wherein the plurality of membrane layers comprises at least 10 membrane layers.

[0137] Aspect 19. The box assembly according to any one of Aspects 1-18 and 20-25, wherein the separation layer has an effective inlet surface region defined by an effective length and an effective width, and wherein the effective length is at least 2.5 times the effective width.

[0138] Aspect 20. The box assembly according to any one of aspects 1-19 and 21-25, further comprising: an outlet channel spacer positioned in an outlet channel, wherein the outlet channel spacer is configured to accommodate fluid flow.

[0139] Aspect 21. The box assembly according to any one of Aspects 1-20 and 22-25, further comprising: an inlet channel spacer positioned in an inlet channel, wherein the inlet channel spacer is configured to accommodate fluid flow.

[0140] Aspect 22. The box assembly according to any one of aspects 1-21 and 23-25, wherein at least one of the inlet channel spacer and the outlet channel spacer includes a transverse ridge extending across the separation layer.

[0141] Aspect 23. The box assembly according to any one of Aspects 1-22 and 24-25, wherein the outlet box plate includes an alignment feature and the inlet box plate includes a mating alignment feature, and wherein the alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box plate and the inlet box plate.

[0142] Aspect 24. The box assembly according to any one of Aspects 1-23 and 25-25 further includes fasteners configured to operatively couple the inlet box plate and the outlet box plate.

[0143] Aspect 25. The box assembly according to any one of Aspects 1-24 and 26-25, wherein the fasteners comprise bolts, and The inlet box plate defines a first axial through hole, and the outlet box plate defines a second axial through hole, wherein the first and second axial through holes are configured to be laterally aligned to accommodate bolts. The box assembly further includes a first nut configured to receive one end of a bolt and a second nut configured to receive the opposite end of the bolt, wherein the first nut and the second nut are configured to apply a compressive force to the box assembly.

[0144] Aspect 26. The box assembly according to any one of Aspects 1-25 further includes an attachment seal between the inlet box panel and the outlet box panel, wherein the attachment seal extends laterally around and outside the periphery of the separation layer.

[0145] Aspect 27. A box assembly comprising: An inlet box plate, the inlet box plate defining an inlet flow path, an inlet channel in fluid communication with the inlet flow path, and an inlet opening defining the interface between the inlet flow path and the inlet channel; An outlet box plate, which is configured to be stacked with an inlet box plate, defines an outlet flow path and an outlet channel in fluid communication with the outlet flow path. A separation layer, disposed between an inlet box plate and an outlet box plate and extending from a first lateral end to a second lateral end, wherein the inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form a component flow path; and The inlet retains its characteristic feature, with its inlet opening extending across the inlet flow path.

[0146] Aspect 28. The box assembly according to any one of Aspects 27 and 29-51, wherein the inlet channel extends from an inlet midpoint between the first lateral end and the second lateral end toward the second lateral end.

[0147] Aspect 29. The box assembly according to any one of Aspects 27-28 and 30-51, wherein the outlet channel extends from an outlet intermediate position between the first lateral end and the second lateral end toward the first lateral end.

[0148] Aspect 30. The box assembly according to any one of Aspects 27-29 and 31-51, wherein the width of the effective inlet surface region gradually narrows from a first width to a second width.

[0149] Aspect 31. The box assembly according to any one of Aspects 27-30 and 32-51, further comprising: a flow guide positioned within the inlet channel toward a first lateral end, wherein the flow guide defines a first width.

[0150] Aspect 32. The box assembly according to aspect 31, wherein the flow guide gradually narrows from a first width to a second width.

[0151] Aspect 33. The box assembly according to aspect 31, wherein the inlet box panel defines a second width.

[0152] Aspect 34. The box assembly according to any one of Aspects 27-33 and 34-51, wherein the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel, and wherein the inlet opening defines an elongated slit spanning a first width.

[0153] Aspect 35. The box assembly according to any one of Aspects 27-34 and 36-51, wherein the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel, and wherein the inlet opening is circular.

[0154] Aspect 36. The box assembly according to any one of Aspects 27-35 and 37-51, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening defines an elongated slit spanning a first width.

[0155] Aspect 37. The box assembly according to any one of Aspects 27-36 and 38-51, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening is circular.

[0156] Aspect 38. The box assembly according to any one of Aspects 27-37 and 39-51, further comprising an assembly inlet, wherein an inlet flow path defines an axial through-hole, and wherein an inlet box plate is configured to fluidly couple the assembly inlet and the inlet channel.

[0157] Aspect 39. The box assembly according to any one of Aspects 27-38 and 40-51, further comprising an assembly outlet, wherein an outlet flow path defines an axial through-hole, and wherein an outlet box plate is configured to fluidly couple the assembly outlet and the outlet channel.

[0158] Aspect 40. The box assembly according to any one of Aspects 27-39 and 41-51 further includes an outlet retaining feature configured to cover an outlet opening of the outlet flow path, wherein the outlet opening defines an interface between the outlet flow path and the outlet channel.

[0159] Aspect 41. The box assembly according to any one of Aspects 27-40 and 42-51 further includes a separation layer seal mounted between the inlet box plate and the outlet box plate, wherein the separation layer seal contacts the inlet box plate and the outlet box plate, and wherein the separation layer seal is configured to fluidly seal the peripheral region of the separation layer, the peripheral region of the inlet passage, and the peripheral region of the outlet passage.

[0160] Aspect 42. The box assembly according to any one of Aspects 27-41 and 43-51, wherein the separation layer seal comprises an overmolded gasket.

[0161] Aspect 43. The box assembly according to any one of Aspects 27-42 and 44-51, wherein the separation layer comprises a membrane stack, the membrane stack further comprising a plurality of membrane layers, and wherein the plurality of membrane layers comprises at least 10 membrane layers.

[0162] Aspect 44. The box assembly according to any one of Aspects 27-43 and 45-51, wherein the separation layer has an effective inlet surface region defined by an effective length and an effective width, and wherein the effective length is at least 2.5 times the effective width.

[0163] Aspect 45. The box assembly according to any one of Aspects 27-44 and 46-51, further comprising: an outlet channel spacer positioned in an outlet channel, wherein the outlet channel spacer is configured to accommodate fluid flow.

[0164] Aspect 46. The box assembly according to any one of Aspects 27-45 and 47-51, further comprising: an inlet channel spacer positioned in an inlet channel, wherein the inlet channel spacer is configured to accommodate fluid flow.

[0165] Aspect 47. The box assembly according to any one of Aspects 27-46 and 48-51, wherein at least one of the inlet channel spacer and the outlet channel spacer includes a transverse ridge extending across the separation layer.

[0166] Aspect 48. The box assembly according to any one of Aspects 27-47 and 49-51, wherein the outlet box plate includes an alignment feature and the inlet box plate includes a mating alignment feature, and wherein the alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box plate and the inlet box plate.

[0167] Aspect 49. The box assembly according to any one of Aspects 27-48 and 50-51 further includes fasteners configured to operatively couple the inlet box plate and the outlet box plate.

[0168] Aspect 50. The box assembly according to any one of Aspects 27-49 and 51, wherein the fastener includes a bolt, and wherein the inlet box plate defines a first axial through hole and the outlet box plate defines a second axial through hole, wherein the first axial through hole and the second axial through hole are configured to be laterally aligned to receive the bolt, and wherein the box assembly further includes a first nut configured to receive one end of the bolt and a second nut configured to receive the opposite end of the bolt, and wherein the first nut and the second nut are configured to apply a compressive force to the box assembly.

[0169] Aspect 51. The box assembly according to any one of Aspects 27-50, further comprising an attachment seal between the inlet box panel and the outlet box panel, wherein the attachment seal extends laterally around and outside the periphery of the separation layer.

[0170] Aspect 52. A box assembly comprising: An inlet box plate, the inlet box plate defining an inlet flow path, an inlet channel in fluid communication with the inlet flow path, and an inlet opening defining the interface between the inlet flow path and the inlet channel, wherein the inlet opening is an elongated slit; An outlet box plate is configured to be stacked with an inlet box plate. The outlet box plate defines an outlet flow path, an outlet channel in fluid communication with the outlet flow path, and an outlet opening that defines the interface between the outlet flow path and the outlet channel. A separation layer is disposed between the inlet box plate and the outlet box plate and extends from a first lateral end to a second lateral end, wherein the inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form a component flow path. The inlet channel defines the effective inlet surface area of ​​the separation layer, the outlet channel defines the effective outlet surface area of ​​the separation layer, and the inlet opening extends laterally along the width of the effective inlet surface area.

[0171] Aspect 53. The box assembly according to any one of Aspects 52 and 54-75, wherein the inlet channel extends from an inlet midpoint between the first lateral end and the second lateral end toward the second lateral end.

[0172] Aspect 54. The box assembly according to any one of Aspects 52-53 and 55-75, wherein the outlet channel extends from an outlet intermediate position between the first lateral end and the second lateral end toward the first lateral end.

[0173] Aspect 55. The box assembly according to any one of aspects 52-54 and 56-75, wherein the width of the effective inlet surface region gradually narrows from a first width to a second width.

[0174] Aspect 56. The box assembly according to any one of aspects 52-55 and 57-75, further comprising: a flow guide positioned within the inlet channel toward a first lateral end, wherein the flow guide defines a first width.

[0175] Aspect 57. The box assembly according to aspect 56, wherein the flow guide gradually narrows from a first width to a second width.

[0176] Aspect 58. The box assembly according to aspect 56, wherein the inlet box plate defines a second width.

[0177] Aspect 59. The box assembly according to any one of Aspects 52-58 and 59-75, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening defines an elongated slit spanning a first width.

[0178] Aspect 60. The box assembly according to any one of Aspects 52-59 and 61-75, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening is circular.

[0179] Aspect 61. The box assembly according to any one of Aspects 52-60 and 62-75, further comprising an assembly inlet, wherein an inlet flow path defines an axial through-hole, and wherein an inlet box plate is configured to fluidly couple the assembly inlet and the inlet channel.

[0180] Aspect 62. The box assembly according to any one of Aspects 52-61 and 63-75, further comprising an assembly outlet, wherein an outlet flow path defines an axial through-hole, and wherein an outlet box plate is configured to fluidly couple the assembly outlet and the outlet channel.

[0181] Aspect 63. The box assembly according to any one of aspects 52-62 and 63-75 further includes an inlet retaining feature configured to cover an inlet opening of the inlet flow path, wherein the inlet opening defines an interface between the inlet flow path and the inlet channel.

[0182] Aspect 64. The box assembly according to any one of Aspects 52-63 and 65-75 further includes an outlet retaining feature configured to cover an outlet opening of an outlet flow path, wherein the outlet opening defines an interface between the outlet flow path and the outlet channel.

[0183] Aspect 65. The box assembly according to any one of Aspects 52-64 and 66-75 further includes a separation layer seal mounted between the inlet box plate and the outlet box plate, wherein the separation layer seal contacts the inlet box plate and the outlet box plate, and wherein the separation layer seal is configured to fluidly seal the peripheral region of the separation layer, the peripheral region of the inlet passage, and the peripheral region of the outlet passage.

[0184] Aspect 66. The box assembly according to any one of Aspects 52-65 and 67-75, wherein the separation layer seal comprises an overmolded gasket.

[0185] Aspect 67. The box assembly according to any one of Aspects 52-66 and 68-75, wherein the separation layer comprises a membrane stack, the membrane stack further comprising a plurality of membrane layers, and wherein the plurality of membrane layers comprises at least 10 membrane layers.

[0186] Aspect 68. The box assembly according to any one of Aspects 52-67 and 69-75, wherein the separation layer has an effective inlet surface region defined by an effective length and an effective width, and wherein the effective length is at least 2.5 times the effective width.

[0187] Aspect 69. The box assembly according to any one of aspects 52-68 and 70-75, further comprising: an outlet channel spacer positioned in an outlet channel, wherein the outlet channel spacer is configured to accommodate fluid flow.

[0188] Aspect 70. The box assembly according to any one of aspects 52-69 and 71-75, further comprising: an inlet channel spacer positioned in an inlet channel, wherein the inlet channel spacer is configured to accommodate fluid flow.

[0189] Aspect 71. The box assembly according to any one of aspects 52-70 and 72-75, wherein at least one of the inlet channel spacer and the outlet channel spacer includes a transverse ridge extending across the separation layer.

[0190] Aspect 72. The box assembly according to any one of Aspects 52-71 and 73-75, wherein the outlet box plate includes an alignment feature and the inlet box plate includes a mating alignment feature, and wherein the alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet box plate and the inlet box plate.

[0191] Aspect 73. The box assembly according to any one of aspects 52-72 and 73-75 further includes fasteners configured to operatively couple the inlet box plate and the outlet box plate.

[0192] Aspect 74. The box assembly according to any one of Aspects 52-73 and 75, wherein the fasteners include bolts, and wherein the inlet box plate defines a first axial through-hole and the outlet box plate defines a second axial through-hole, wherein the first and second axial through-holes are configured to be laterally aligned to receive the bolt, and wherein the box assembly further includes a first nut configured to receive one end of the bolt and a second nut configured to receive the opposite end of the bolt, and wherein the first and second nuts are configured to apply a compressive force to the box assembly.

[0193] Aspect 75. The box assembly according to any one of Aspects 52-74, further comprising an attachment seal between the inlet box panel and the outlet box panel, wherein the attachment seal extends laterally around and outside the periphery of the separation layer.

[0194] It should be noted that, as used in this specification and the appended claims, the phrase "configuration" describes a system, apparatus / device, or other structure as being constructed to perform a particular task or employing a particular configuration. The word "configuration" may be used interchangeably with similar terms such as "arrangement / setup," "construction," "manufacturing," etc.

[0195] It should be noted that the terms "having," "including," "comprise," and their variations are not restrictive and, where such terms appear in the appended specification and claims, are used in their open-ended sense to generally mean "including but not limited to." Furthermore, "a," "an," "the," "at least one," and "one or more" are used interchangeably herein. Additionally, relative terms such as "left," "right," "front," "forward," "rear," "rear," "backward," "top," "bottom," "side," "upper," "lower," "above," "below," "horizontal," and "vertical" may be used herein, and if so, from the angle shown in the specific figures. However, these terms are used only for simplification and do not limit the interpretation of any of the embodiments described.

[0196] Additionally, it should be understood that describing any particular element as connected to or coupled to another element can be a direct connection or coupling, or an indirect coupling / connection via an intervening element.

[0197] Unless otherwise stated, all figures used in the specification and claims to express the size, quantity, and physical properties of features should be understood to be modified by the term "about" in all cases. Therefore, unless indicated to the contrary, the numerical parameters set forth in the foregoing specification and appended claims are approximate values ​​that may vary according to the desired properties sought to be obtained by one of skill in the art using the teachings disclosed herein. The use of numerical ranges by endpoints encompasses all numbers within the range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5) and any range within the range.

[0198] All publications and patent applications in this specification represent the level of skill of one ordinary person in the art to which this technology pertains. All publications and patent applications are incorporated herein by reference to the extent that each individual publication or patent application is specifically and individually indicated as being incorporated herein by reference. In the event of any inconsistency between the disclosure of this application and the disclosure of any document incorporated herein by reference, the disclosure of this application shall prevail.

[0199] The foregoing description of exemplary embodiments has been presented for illustrative and descriptive purposes. It is not intended to be exhaustive or to limit the embodiments to the precise forms disclosed. Modifications and variations are possible in light of the foregoing teachings. Any or all features of the disclosed embodiments may be applied individually or in any combination and are not intended to be limiting, but are purely illustrative. It should be understood that the above description is intended to be illustrative and not limiting, and the claims are not limited to the illustrative embodiments described herein.

Claims

1. A cassette assembly comprising: an inlet cassette plate defining an inlet flow path and an inlet channel extending from the inlet flow path; an outlet cassette plate configured in a stacked arrangement with the inlet cassette plate, the outlet cassette plate defining an outlet flow path and an outlet channel extending from the outlet flow path; a separation layer disposed between the inlet cassette plate and the outlet cassette plate and extending from a first lateral end to a second lateral end, wherein the inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form an assembly flow path, wherein the inlet channel defines an effective inlet surface area of the separation layer and the outlet channel defines an effective outlet surface area of the separation layer, and wherein the effective inlet surface area defines a first width toward the first lateral end and a second width toward the second lateral end, and wherein the first width is less than the second width.

2. A cassette assembly comprising: an inlet cassette plate defining an inlet flow path, an inlet channel in fluid communication with the inlet flow path, and an inlet opening defining an interface between the inlet flow path and the inlet channel; an outlet cassette plate configured in a stacked arrangement with the inlet cassette plate, the outlet cassette plate defining an outlet flow path and an outlet channel in fluid communication with the outlet flow path; a separation layer disposed between the inlet cassette plate and the outlet cassette plate and extending from a first lateral end to a second lateral end, wherein the inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form an assembly flow path; and an inlet retention feature extending across the inlet opening of the inlet flow path.

3. The cassette assembly of claim 2, wherein the inlet channel extends from an inlet mid- position between the first lateral end and the second lateral end toward the second lateral end.

4. The cassette assembly of claim 2, wherein the outlet channel extends from an outlet mid- position between the first lateral end and the second lateral end toward the first lateral end.

5. The cassette assembly of claim 2, wherein the inlet channel defines an effective inlet surface area of the separation layer and the outlet channel defines an effective outlet surface area of the separation layer.

6. The cassette assembly of claim 5, wherein the effective inlet surface area defines a first width toward the first lateral end and a second width toward the second lateral end, wherein the first width is less than the second width, and wherein the effective inlet surface area tapers from the first width to the second width.

7. The cartridge assembly of claim 6, further comprising: a flow director positioned within the inlet channel toward the first lateral end, wherein the flow director defines the first width, wherein the flow director tapers from the first width to the second width, and wherein the inlet cassette plate defines the second width.

8. The cassette assembly of claim 6, wherein the inlet flow path has an inlet opening defining an interface between the inlet flow path and the inlet channel, and wherein the inlet opening defines one of an elongated slit or a circular shape spanning the first width.

9. The cartridge assembly of claim 6, wherein the outlet flow path has an outlet opening defining an interface between the outlet flow path and the outlet channel, and wherein the outlet opening defines one of an elongated slit or a circular shape spanning the first width.

10. The cartridge assembly of claim 2, further comprising an assembly inlet, wherein the inlet flow path defines an axial through-hole, and wherein the inlet cartridge plate is configured to fluidically couple the assembly inlet and the inlet channel.

11. The cartridge assembly of claim 2, further comprising an assembly outlet, wherein the outlet flow path defines an axial through-hole, and wherein the outlet cartridge plate is configured to fluidically couple the assembly outlet and the outlet channel.

12. The cartridge assembly of claim 2, further comprising an outlet retention feature configured to cover an outlet opening of the outlet flow path, wherein the outlet opening defines an interface between the outlet flow path and the outlet channel.

13. The cartridge assembly of claim 2, further comprising a separation layer seal mounted between the inlet cartridge plate and the outlet cartridge plate, wherein the separation layer seal is in contact with the inlet cartridge plate and the outlet cartridge plate, and wherein the separation layer seal is configured to fluidically seal a peripheral region of the separation layer, a peripheral region of the inlet channel, and a peripheral region of the outlet channel.

14. The cartridge assembly of claim 2, wherein the separation layer comprises a film stack, the film stack further comprising a plurality of film layers, and wherein the plurality of film layers comprises at least 10 film layers.

15. The cartridge assembly of claim 2, further comprising: an outlet channel spacer positioned in the outlet channel, wherein the outlet channel spacer is configured to accommodate a fluid flow.

16. The cartridge assembly of claim 2, further comprising: an inlet channel spacer positioned in the inlet channel, wherein the inlet channel spacer is configured to accommodate a fluid flow.

17. The cartridge assembly of claim 2, wherein the outlet cartridge plate comprises an alignment feature, and the inlet cartridge plate comprises a mating alignment feature, and wherein the alignment feature and the mating alignment feature are laterally aligned to operatively couple the outlet cartridge plate and the inlet cartridge plate.

18. The cartridge assembly of claim 2, further comprising a fastener configured to operatively couple the inlet cartridge plate and the outlet cartridge plate.

19. The cartridge assembly of claim 2, further comprising an attachment seal between the inlet cartridge plate and the outlet cartridge plate, wherein the attachment seal extends laterally around and outside a periphery of the separation layer.

20. A cartridge assembly, comprising: an inlet cartridge plate defining an inlet flow path, an inlet channel in fluid communication with the inlet flow path, and an inlet opening defining an interface between the inlet flow path and the inlet channel, wherein the inlet opening is an elongated slit; an outlet cartridge plate configured to be arranged in a stacked arrangement with the inlet cartridge plate, the outlet cartridge plate defining an outlet flow path, an outlet channel in fluid communication with the outlet flow path, and an outlet opening defining an interface between the outlet flow path and the outlet channel; a separation layer disposed between the inlet cassette plate and the outlet cassette plate and extending from the first lateral end to the second lateral end, wherein the inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer to form a component flow path, wherein the inlet channel defines an effective inlet surface area of the separation layer, the outlet channel defines an effective outlet surface area of the separation layer, and the inlet opening extends laterally along a width of the effective inlet surface area.

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