Compound composition containing azoxystrobin, pesticide and application

Abstract

The invention discloses a compound composition containing azoxystrobin, a pesticide and application. The compound composition containing azoxystrobin comprises 5-15 parts of a component A, 1-75 parts of a component B and an auxiliary, and the component A is azoxystrobin; the component B is one of fluazinam, prothioconazole and fluxapyroxad; auxiliary agents comprise 0.5 to 1.5 parts of silicon dioxide and 0.2 to 0.6 part of calcium oxide; when the component B in the prepared composition is fluazinam, the composition is suitable for ginger stem rot, when the component B is prothioconazole, the composition is suitable for peanut southern blight, and when the component B is fluxapyroxad, the composition is suitable for rice seedling blight.

Description

Technical Field

[0001] This application relates to a process for producing pesticide granules, and more particularly to a compound composition containing pyraclostrobin, a pesticide, and its application. Background Technology

[0002] Azoxystrobin-containing compound technology has become a core direction in pesticide research and development. By combining it with ingredients such as difenoconazole, propiconazole, metalaxyl, and fludioxonil, it forms a control system covering multiple diseases including downy mildew, sheath blight, and soil-borne diseases. Classic formulations such as 32.5% benzyl-pyraclostrobin suspension concentrate dominate the market due to its broad-spectrum and high-efficiency properties. Ternary compound formulations further expand the control spectrum and delay resistance development. Domestically, the focus is on seed treatment, slow-release formulations, and synergistic applications with insecticides such as thiamethoxam to meet the needs of integrated pest management and resistance control.

[0003] Existing pesticides exhibit insufficient stability under high-temperature conditions, with azoxystrobin exhibiting a prominent issue of thermal decomposition. At temperatures above 40°C, the degradation rate of its compound formulations' active ingredients exceeds 30%, and the decomposition rate increases exponentially with increasing temperature. Mechanistically, high temperatures accelerate photolysis, and some compound components may catalyze degradation. Although improvements have been made through antioxidants or microencapsulation technology, the temperature inside transport vehicles often exceeds 50°C, and the reduced permeability of the packaging exacerbates decomposition, leading to reduced efficacy and unstable control, becoming a key limiting factor for product promotion.

[0004] Furthermore, when existing pyraclostrobin-containing pesticides are applied to control diseases such as ginger stem rot, peanut white mold, and rice damping-off, pyraclostrobin cannot effectively synergize with other components, and may even exhibit reduced efficacy. Summary of the Invention

[0005] To address the issues of thermal decomposition of fungicidal components and the inability of pyraclostrobin to achieve synergistic effects with other components during the storage and transportation of pyraclostrobin-containing pesticides, a compound composition containing pyraclostrobin, a pesticide, and its application are provided.

[0006] The above-mentioned objective of this invention is achieved through the following technical solutions: A compound composition containing pyraclostrobin, comprising the following components in parts by weight: component A 5-15 parts, component B 1-75 parts, and adjuvants. Component A is azoxystrobin; Component B is one of fluazinam, prothioconazole, and fluazinam; The additives include 0.5 to 1.5 parts silicon dioxide and 0.2 to 0.6 parts calcium oxide.

[0007] By employing the above technical solutions, silica microparticles fill the gaps between particles, significantly improving powder flowability by reducing van der Waals forces and electrostatic adsorption between particles. This prevents clumping caused by moisture absorption or pressure during storage. Simultaneously, physical adsorption extends the retention time of azoxystrobin, reducing rainwater runoff losses. In soil treatment, its alkaline surface can neutralize acidic soil, indirectly optimizing the activity of azoxystrobin in the rhizosphere environment. Calcium oxide, being highly alkaline, reacts with water to generate calcium hydroxide and releases heat, rapidly neutralizing soil acidity and disrupting the lipid structure of fungal cell membranes, enhancing the penetration efficiency of azoxystrobin against soil-borne pathogens. Furthermore, calcium oxide gradually transforms into calcium peroxide in humid environments, continuously releasing reactive oxygen species that oxidize the proteins and DNA of pathogens, creating a dual killing effect combined with the respiratory inhibition mechanism of azoxystrobin.

[0008] Optionally, the mass ratio of component A to component B is (1:5) to (5:1).

[0009] By adopting the above technical solution, when the mass ratio of component A to component B is (1:5) to (5:1), component A and component B are more likely to have a synergistic effect on penetration.

[0010] Optionally, it may also include 0.3 to 0.6 parts of cashew phosphate.

[0011] By adopting the above technical solution, the phosphate group (PO4) of cashew phenolic phosphate ester is obtained. - It adsorbs onto the surface of azoxystrobin particles, providing electrostatic repulsion; its C 15 Long-chain alkyl groups form a steric hindrance layer, which doubles the inhibition of the oval ripening of particles at high temperatures. The hydrophobic alkyl chain of cashew phenol encapsulates the pyraclostrobin particles, which prevents high-temperature curdling by reducing the surface tension of the system.

[0012] Optionally, titanium tetrachloride can be used as a catalyst in the preparation of cashew phenolic phosphate.

[0013] Through the above scheme, titanium tetrachloride, as a strong Lewis acid, activates the P=O bond of diethyl chlorophosphate, lowers its LUMO energy level, accelerates the nucleophilic attack of the phenolic oxygen group of cashew phenol, and improves the rate and selectivity of phosphorylation reaction. Titanium tetrachloride preferentially catalyzes the monosubstituted reaction, reduces the formation of diphosphoesterification byproducts, and avoids impurities interfering with the thermal stability of pyraclostrobin.

[0014] Optionally, it may also include 0.5 to 1.5 parts of rosmarinic acid. By adopting the above technical solution, the hydrophobic ring of rosmarinic acid disrupts the lipid layer of the pathogen cell membrane, increases membrane permeability, and accelerates the entry of azoxystrobin into the mitochondrial target site. At the same time, the ortho-phenolic hydroxyl group of rosmarinic acid captures the alkoxy radicals (RO·) generated by the degradation of azoxystrobin, interrupting the oxidation chain reaction. Rosemary protects the unsaturated chain of cashew phenol from oxidative chain breaking, reducing the decrease in efficacy of drug components due to thermal decomposition.

[0015] The second objective of this invention is as follows: Compound compositions containing pyraclostrobin are used for the prevention and control of ginger stem rot, peanut white mold, and rice damping-off.

[0016] The third inventive objective of this invention is achieved through the following technical solution: A pesticide is obtained by mixing any of the above-mentioned azoxystrobin-containing compound compositions with a carrier.

[0017] Optionally, components A and B may account for 0.1% to 5% of the total mass of the pesticide.

[0018] By adopting the above technical solution, the synergistic effect is better when the mass of components A and B accounts for 0.1% to 5% of the total mass.

[0019] In summary, this application has at least the following beneficial effects: (1) When a combination of azoxystrobin and fluazinam, prothioconazole or fluazinam is applied to control ginger stem base rot, peanut white mold, and rice damping-off, it has excellent effect. (2) The physical adsorption of silica prolongs the action time of pyraclostrobin and reduces the loss caused by rainwater erosion. In soil treatment, its alkaline surface can neutralize acidic soil and enhance the effect of pyraclostrobin in the rhizosphere environment. (3) Calcium oxide is highly alkaline and releases heat when it comes into contact with water, which quickly neutralizes soil acidity and destroys the cell membrane structure of fungi. At the same time, calcium oxide is converted into calcium peroxide and continuously releases active oxygen, which oxidizes the proteins and DNA of pathogens. This, together with the respiratory inhibition mechanism of pyraclostrobin, forms a dual killing effect. Detailed Implementation

[0020] raw material Azoxystrobin was purchased from Nantong Taihe Chemical Co., Ltd. Fluazinam was purchased from Jiangsu Youjia Plant Protection Co., Ltd. Prothioconazole was purchased from the Beijing branch of Zhongnong Lihua Biotechnology Co., Ltd. Fluopyram was purchased from Inner Mongolia Lingsheng Crop Technology Co., Ltd. Rosmarin, purity ≥98%, purchased from Shanghai Yuanye Biotechnology Co., Ltd. The carrier was kaolin with a SiO2 content of 45wt% and a mesh size of 325, which was purchased from Shijiazhuang Tourmaline Mineral Products Co., Ltd. Tetrachlorobenzoquinone, purity ≥99%, purchased from Anda Yidu Chemical Co., Ltd.; Cashew phenol, purity ≥95%, purchased from Shanghai Yuanye Biotechnology Co., Ltd. Titanium tetrachloride, purity ≥99%, purchased from Shanghai Yuanye Biotechnology Co., Ltd. Titanium trichloride, purity ≥98%, purchased from Wuhan Kanos Technology Co., Ltd. Strongly basic anion exchange resin, purchased from Tianjin Yunkai Resin Technology Co., Ltd. Sodium bicarbonate, silicon dioxide, and calcium oxide are all commercially available.

[0021] Preparation Example 1 A cashew phenolic phosphate ester, prepared by the following method: Add 1g of tetrachlorobenzoquinone to 100g of cashew nut powder, and stir magnetically at 400rpm for 20min to obtain a mixture. Add 0.1g of titanium tetrachloride to the mixture, then add the mixture containing titanium tetrachloride dropwise to 60g of diethyl chlorophosphate at a rate of 10mL / min, and then let it stand for 3h to obtain the reaction solution. After adjusting the pH to 3.2±1 using 500mL of 96g / L sodium bicarbonate solution, a strongly basic anion exchange resin was added. The mixture was then washed twice with deionized water and distilled under a vacuum of 70kPa and a distillation endpoint temperature of 100℃ to obtain cashew phenolic phosphate.

[0022] Preparation Example 2 A cashew phenolic phosphate ester, which differs from Preparation Example 1 in that titanium trichloride is used in place of titanium tetrachloride by an equal mass, while the rest is the same as Preparation Example 1.

[0023] Example 1 A compound composition containing azoxystrobin, comprising the following components by weight: 1 kg of azoxystrobin, 0.5 kg of fluazinam, 0.1 kg of silica, and 0.05 kg of calcium oxide.

[0024] When applying, the compound composition containing pyraclostrobin is mixed with a carrier to prepare the corresponding formulation of pesticide.

[0025] Kaolin is used as the carrier here.

[0026] The specific preparation method is as follows: S1: 98.35 kg of kaolin was dried at 105℃ until the moisture content was ≤1%, and then sieved through a 400-mesh sieve to obtain pretreated kaolin; S2: Kaolin, azoxystrobin, fluazinam, silica, and calcium oxide are added sequentially to the reaction vessel and mixed at 100 rpm for 15 min to obtain a mixture; S3: Add the mixture to a granulator and extrude it into granules. The screw speed is 20 rpm and the die diameter is 1.0 mm. Dry the resulting granules in air at 50°C for 10 min to obtain the pesticide.

[0027] Comparative Example 1 A pesticide, which differs from Example 1 in that: no silica is added and the amount of kaolin is 98.45 kg, while the rest is the same as in Example 1.

[0028] Comparative Example 2 A pesticide, which differs from Example 1 in that: no calcium oxide is added and the amount of kaolin is 98.4 kg, while the rest of the ingredients are the same as in Example 1.

[0029] Example 2 A pesticide differs from Example 1 in that: after adding calcium oxide in step S2 and before mixing, 0.05 kg of cashew phenolic phosphate and 98.30 kg of kaolin are added, while the rest is the same as in Example 1.

[0030] Example 3 A pesticide that differs from Example 2 in that: cashew phenolic phosphate is derived from Preparation Example 2, while the rest is the same as in Example 2.

[0031] Example 4 A pesticide differs from Example 2 in that: after adding calcium oxide in step S2 and before mixing, 0.1 kg of rosmarinic acid and 98.20 kg of kaolin are added, while the rest is the same as in Example 2.

[0032] Example 5 A pesticide, which differs from Example 4 in that: the amount of fluazinam is 5 kg and the amount of kaolin is 393.70 kg, while the rest of the ingredients are the same as in Example 4.

[0033] Example 6 A pesticide, which differs from Example 4 in that: fluazinam is 0.2 kg and kaolin is 78.5 kg, while the rest is the same as in Example 4.

[0034] Example 7 A pesticide, which differs from Example 4 in that: fluazinam is 6.2 kg and kaolin is 472.5 g, while the rest is the same as in Example 4.

[0035] Example 8 A pesticide, which differs from Example 4 in that: fluazinam is 0.11 kg and kaolin is 72.59 kg, while the rest is the same as in Example 4.

[0036] Example 9 A pesticide, which differs from Example 4 in that: the kaolin content is 1498.2 kg, while the rest of the ingredients are the same as in Example 4.

[0037] Example 10 A pesticide, which differs from Example 4 in that: the kaolin content is 28.2 kg, while the rest of the ingredients are the same as in Example 4.

[0038] Example 11 A pesticide, which differs from Example 4 in that: the kaolin content is 1598.2 kg, while the rest of the ingredients are the same as in Example 4.

[0039] Example 12 A pesticide, which differs from Example 4 in that: the kaolin content is 18.2 kg, while the rest of the ingredients are the same as in Example 4.

[0040] Example 13 A pesticide differs from Example 1 in that 0.6 kg of prothioconazole is used instead of 0.5 kg of fluazinam, and 0.6 kg of azoxystrobin and 98.65 kg of kaolin are used, while the rest are the same as in Example 1.

[0041] Comparative Example 3 A pesticide, which differs from Example 13 in that: no silica is added and the amount of kaolin is 98.75 kg, while the rest of the ingredients are the same as in Example 13.

[0042] Comparative Example 4 A pesticide that differs from Example 13 in that it does not contain calcium oxide and the amount of kaolin is 98.7 kg, while the rest of the ingredients are the same as in Example 13.

[0043] Example 14 A pesticide differs from Example 13 in that: after adding calcium oxide in step S2 and before mixing, 0.05 kg of cashew phenolic phosphate and 98.6 kg of kaolin are added, while the rest is the same as in Example 13.

[0044] Example 15 A pesticide that differs from Example 14 in that: cashew phenolic phosphate is derived from Preparation Example 2, while the rest is the same as in Example 14.

[0045] Example 16 A pesticide differs from Example 14 in that: after adding calcium oxide in step S2 and before mixing, 0.1 kg of rosmarinic acid is added, and the amount of kaolin is 98.5 kg; the rest of the ingredients are the same as in Example 14.

[0046] Example 17 A pesticide, which differs from Example 16 in that: 0.12 kg of prothioconazole and 58.98 kg of kaolin are used, while the rest are the same as in Example 16.

[0047] Example 18 A pesticide, which differs from Example 16 in that: 3 kg of prothioconazole and 296.1 kg of kaolin are used, while the rest of the ingredients are the same as in Example 16.

[0048] Example 19 A pesticide, which differs from Example 16 in that: 0.09 kg of prothioconazole and 56.51 kg of kaolin are used, while the rest of the ingredients are the same as in Example 16.

[0049] Example 20 A pesticide, differing from Example 16 in that: 5.1 kg of prothioconazole and 469 kg of kaolin are used, while the remaining components are the same as in Example 16. Example 21 A pesticide, which differs from Example 16 in that: the kaolin content is 1198.5 kg, while the rest of the ingredients are the same as in Example 16.

[0050] Example 22 A pesticide, which differs from Example 16 in that: the kaolin content is 22.5 kg, while the rest of the ingredients are the same as in Example 16.

[0051] Example 23 A pesticide, which differs from Example 16 in that: the kaolin content is 1298.5 kg, while the rest of the ingredients are the same as in Example 16.

[0052] Example 24 A pesticide, which differs from Example 16 in that: the kaolin content is 18.5 kg, while the rest of the ingredients are the same as in Example 16.

[0053] Example 25 A pesticide that differs from Example 1 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the components are the same as in Example 1.

[0054] Comparative Example 5 A pesticide differs from Comparative Example 1 in that it uses fluopyram and other components instead of fluazinam, while the rest is the same as Comparative Example 1.

[0055] Comparative Example 6 A pesticide differs from Comparative Example 2 in that it uses fluopyram and other components instead of fluazinam, while the rest is the same as Comparative Example 2.

[0056] Example 26 A pesticide that differs from Example 2 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the components are the same as in Example 2.

[0057] Example 27 A pesticide that differs from Example 3 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 3.

[0058] Example 28 A pesticide, which differs from Example 4 in that it uses fluopyram and other similar products instead of fluazinam, while the rest is the same as in Example 4.

[0059] Example 29 A pesticide that differs from Example 5 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 5.

[0060] Example 30 A pesticide, which differs from Example 6 in that 0.6 kg of fluopyram is used instead of 0.48 kg of fluazinam, while the rest is the same as in Example 6.

[0061] Example 31 A pesticide that differs from Example 7 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 7.

[0062] Example 32 A pesticide that differs from Example 8 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 8.

[0063] Example 33 A pesticide that differs from Example 9 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 9.

[0064] Example 34 A pesticide that differs from Example 10 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 10.

[0065] Example 35 A pesticide that differs from Example 11 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 11.

[0066] Example 36 A pesticide that differs from Example 12 in that it uses fluopyram and other similar products instead of fluazinam, while the rest of the pesticide is the same as in Example 12.

[0067] For details of some components in Examples 1-36 and Comparative Examples 1-6, please refer to Table 1. In Table 1, the units for Component A, Component B, Carrier, and Pesticide are all in kg.

[0068] Example 37 A pesticide, which differs from Example 4 in that: 0.5 kg of azoxystrobin, 0.1 kg of fluazinam, 0.05 kg of silica, 0.02 kg of calcium oxide, 0.03 kg of cashew phenolic phosphate, and 0.05 kg of rosmarinic acid are used, while the rest of the components are the same as in Example 4.

[0069] Example 38 A pesticide, which differs from Example 4 in that: 1.5 kg of azoxystrobin, 7.5 kg of fluazinam, 0.15 kg of silica, 0.06 kg of calcium oxide, 0.06 kg of cashew phenolic phosphate, and 0.15 kg of rosmarinic acid are used, while the rest are the same as in Example 4.

[0070] Example 39 A pesticide, which differs from Example 16 in that: 0.5 kg of azoxystrobin, 0.1 kg of prothioconazole, 0.05 kg of silica, 0.02 kg of calcium oxide, 0.03 kg of cashew phenolic phosphate, and 0.05 kg of rosmarinic acid are used, while the rest are the same as in Example 16.

[0071] Example 40 A pesticide, which differs from Example 16 in that: 1.5 kg of azoxystrobin, 7.5 kg of prothioconazole, 0.15 kg of silica, 0.06 kg of calcium oxide, 0.06 kg of cashew phenolic phosphate, and 0.15 kg of rosmarinic acid are used, while the rest are the same as in Example 16.

[0072] Example 41 A pesticide differs from Example 28 in that: 0.5 kg of azoxystrobin, 0.1 kg of fluopyram, 0.05 kg of silica, 0.02 kg of calcium oxide, 0.03 kg of cashew phenolic phosphate, and 0.05 kg of rosmarinic acid are used, while the rest are the same as in Example 28.

[0073] Example 42 A pesticide differs from Example 28 in that: 1.5 kg of azoxystrobin, 7.5 kg of fluopyram, 0.15 kg of silica, 0.06 kg of calcium oxide, 0.06 kg of cashew phenolic phosphate, and 0.15 kg of rosmarinic acid are used, while the rest are the same as in Example 28.

[0074] According to GB / T 19136-2021, the thermal storage stability of pesticides was tested for the thermal decomposition resistance of Examples 1-4, Examples 13-16, Examples 25-28, and Examples 37-42. The test conditions were storage at 54±2℃ for 14 days. The results were expressed as the retention rate of active ingredients after thermal storage. The higher the retention rate, the better the thermal decomposition resistance. The test results are shown in Table 2.

[0075] Table 2 Results of Thermal Decomposition Resistance Test Retention rate (%) Retention rate (%) Example 1 90.1 Example 26 95.3 Example 2 95.2 Example 27 92.8 Example 3 93.7 Example 28 98.3 Example 4 98.5 Example 37 85.2 Example 13 90.5 Example 38 84.3 Example 14 94.9 Example 39 83.1 Example 15 93.6 Example 40 84.7 Example 16 98.1 Example 41 86.2 Example 25 89.1 Example 42 85.9 Based on Tables 1-2, the following analyses are conducted on Examples 1-4, Examples 13-16, and Examples 25-28: Comparing Examples 1 and 2, the active ingredient retention rate of the pesticide in Example 1 is greater than that of the pesticide in Example 2; comparing Examples 13 and 14, the active ingredient retention rate of the pesticide in Example 13 is greater than that of the pesticide in Example 14; comparing Examples 25 and 26, the active ingredient retention rate of the pesticide in Example 25 is greater than that of the pesticide in Example 26.

[0076] The difference between Example 1 and Example 2 is that the pesticide in Example 1 does not contain cashew phenolic phosphate; the difference between Example 13 and Example 14 is that the pesticide in Example 13 does not contain cashew phenolic phosphate; the difference between Example 25 and Example 26 is that the pesticide in Example 25 does not contain cashew phenolic phosphate; the hydrophobic alkyl chain of cashew phenol encapsulates the azoxystrobin particles, reducing the surface tension of the system and preventing high-temperature paste formation; it can be seen that the addition of cashew phenolic phosphate is superior.

[0077] Comparing Examples 2 and 3, the active ingredient retention rate of the pesticide in Example 2 is greater than that of the pesticide in Example 3; comparing Examples 14 and 15, the active ingredient retention rate of the pesticide in Example 14 is greater than that of the pesticide in Example 15; comparing Examples 26 and 27, the active ingredient retention rate of the pesticide in Example 26 is greater than that of the pesticide in Example 27.

[0078] The difference between Example 2 and Example 3 is that titanium tetrachloride was used as a catalyst in the preparation of cashew phenolic phosphate in Example 2; the difference between Example 14 and Example 15 is that titanium tetrachloride was used as a catalyst in the preparation of cashew phenolic phosphate in Example 14; the difference between Example 26 and Example 27 is that titanium tetrachloride was used as a catalyst in the preparation of cashew phenolic phosphate in Example 26. Titanium tetrachloride activates the P=O bond of diethyl chlorophosphate, improving the rate and selectivity of the phosphorylation reaction. Titanium tetrachloride preferentially catalyzes the monosubstituted reaction, reducing the generation of impurities that interfere with the thermal stability of azoxystrobin. Therefore, using titanium tetrachloride as a catalyst in the preparation of cashew phenolic phosphate is superior.

[0079] Comparing Examples 2 and 4, the active ingredient retention rate of the pesticide in Example 4 is greater than that of the pesticide in Example 2; comparing Examples 14 and 16, the active ingredient retention rate of the pesticide in Example 16 is greater than that of the pesticide in Example 17; comparing Examples 26 and 28, the active ingredient retention rate of the pesticide in Example 28 is greater than that of the pesticide in Example 26.

[0080] The difference between Example 2 and Example 4 is that rosmarinic acid was added to the pesticide in Example 4; the difference between Example 14 and Example 16 is that rosmarinic acid was added to the pesticide in Example 16; the difference between Example 26 and Example 28 is that rosmarinic acid was added to the pesticide in Example 28. The ortho-hydroxyl group of rosmarinic acid captures the alkoxy radicals (RO·) generated by the degradation of pyraclostrobin, interrupting the oxidation chain reaction, while protecting the unsaturated chain of cashew phenol from oxidative chain breaking, reducing the decrease in efficacy of the drug component due to thermal decomposition; it can be seen that adding rosmarinic acid is superior.

[0081] Field efficacy trials of the herbicide against ginger stem base rot were conducted on Examples 4-12, Examples 37-38, and Comparative Examples 1-2. The trials were conducted in ginger-growing areas, with a total experimental area of ​​5 mu (approximately 0.33 hectares), divided into several experimental zones. Each experimental zone was planted with 2000 ginger plants. Granular herbicide was applied to the base of the stems. The selected ginger plants were of similar growth and were in the stage before the second hilling (when stem base rot was more severe). The herbicide was applied three times consecutively, with an interval of 7 days between each application. The stem base rot was checked and recorded 15 days after the last application. The detection indicators included the number of diseased plants before application, the number of diseased plants 15 days after the last application, and the difference between the number of diseased plants before and after application. The larger the difference between the number of diseased plants, the better the herbicide effect. The test results are shown in Table 3.

[0082] Table 3. Results of field efficacy trials for ginger stem base rot. Based on Tables 1 and 3, Examples 4 to 12 are analyzed: Comparing Examples 4 and 5-8, the disease difference in the pesticide test field of Example 4 was greater than that in the pesticide test fields of Examples 5-8, and the disease difference in the pesticide test fields of Examples 5-6 was greater than that in the pesticide test fields of Examples 7-8.

[0083] The difference between Examples 4, 5-6, and 7-8 is that the mass ratio of azoxystrobin to fluazinam in Examples 4-6 is (1:5) to (5:1), while the mass ratio of azoxystrobin to fluazinam in Example 4 is 2:1. When the mass ratio of azoxystrobin to fluazinam is (1-5) to (5:1), azoxystrobin and fluazinam can have a synergistic effect. It can be seen that the mass ratio of azoxystrobin to fluazinam is (1:5) to (5:1), which is better, and the mass ratio of azoxystrobin to fluazinam is 2:1, which is better within this range.

[0084] Comparing Examples 4 and 9-12, the disease difference in the pesticide test field of Example 4 was greater than that in the pesticide test fields of Examples 9-12, and the disease difference in the pesticide test fields of Examples 9-10 was greater than that in the pesticide test fields of Examples 11-12.

[0085] The difference between Examples 4, 9-10, and 11-12 is that in Examples 4 and 9-10, the combined mass of azoxystrobin and fluazinam accounts for 0.1% to 5% of the total pesticide mass, and in Example 4, the combined mass of azoxystrobin and fluazinam accounts for 1.5% of the total pesticide mass. Within this range, the combined effect of azoxystrobin and fluazinam is better. It can be seen that a combined mass of azoxystrobin and fluazinam accounting for 0.1% to 5% of the total pesticide mass is preferred, and within this range, a combined mass of azoxystrobin and fluazinam accounting for 1.5% of the total pesticide mass is preferred.

[0086] Field efficacy trials of the herbicide against peanut white mold were conducted on Examples 16-24 and Comparative Examples 3-4 in a peanut-growing field in Jinan City, Shandong Province. The trials were conducted on peanut fields that had been continuously cropped for more than 3 years and had a white mold incidence rate >15%. The total trial area was 3 mu (approximately 0.2 hectares), divided into several trial zones, each with an area ≥30 m². 2 The number of peanut plants was 300, the width of the protected area was ≥1.5m, and the peanut variety planted was Huayu 23. The method of applying granules to the roots was used. Pesticides 16-24 and 3-4 of the comparative examples were applied to each experimental area. The number of peanut white mold diseases in each experimental area was investigated before the application of the pesticides. The number of peanut white mold diseases in the experimental fields was investigated 14 days after the application of the pesticides. The difference between the number of diseased plants before and after the application of the pesticides was calculated. The experimental results are shown in Table 4.

[0087] Table 4 Results of field efficacy trials for peanut white mold disease Number of diseased strains before drug treatment Number of diseased plants after treatment Diseased plants are poor Example 16 40 8 32 Example 17 35 10 25 Example 18 42 16 26 Example 19 48 15 23 Example 20 50 27 23 Example 21 49 20 19 Example 22 55 38 17 Example 23 60 45 15 Example 24 45 31 14 Example 39 48 33 15 Example 40 50 35 15 Comparative Example 3 50 35 12 Comparative Example 4 48 25 11 Based on Tables 1 and 4, Examples 16–24 are analyzed as follows: Comparing Examples 16 and 17-20, the disease difference in the pesticide test field of Example 16 was greater than that in the pesticide test fields of Examples 17-20, and the disease difference in the pesticide test fields of Examples 17-18 was greater than that in the pesticide test fields of Examples 19-20.

[0088] The difference between Examples 16, 17-18, and 19-20 is that: in Examples 16-18, the mass ratio of azoxystrobin to prothioconazole is (1:5) to (5:1), while in Example 4, the mass ratio of azoxystrobin to prothioconazole is 1:1; when the mass ratio of azoxystrobin to prothioconazole is (1-5) to (5:1), azoxystrobin and prothioconazole can have a synergistic effect; it can be seen that the mass ratio of azoxystrobin to prothioconazole is (1:5) to (5:1), which is better, and the mass ratio of azoxystrobin to prothioconazole is 1:1 within this range.

[0089] Comparing Examples 16 and 21-24, the disease-causing plant difference in the pesticide test field of Example 16 was greater than that in the pesticide test fields of Examples 21-24, and the disease-causing plant difference in the pesticide test fields of Examples 21-22 was greater than that in the pesticide test fields of Examples 23-24.

[0090] The difference between Examples 16, 21-22, and 23-24 is as follows: In Examples 16 and 21-22, the combined mass of azoxystrobin and prothioconazole accounts for 0.1% to 5% of the total pesticide mass, while in Example 16, the combined mass of azoxystrobin and prothioconazole accounts for 1.2% of the total pesticide mass. Within this range, the combined effect of azoxystrobin and prothioconazole is better. It can be seen that a combined mass of azoxystrobin and prothioconazole accounting for 0.1% to 5% of the total pesticide mass is more preferable, and a combined mass of azoxystrobin and prothioconazole accounting for 1.2% of the total pesticide mass is more preferable within this range.

[0091] According to NY / T 1464.14-2007 Guidelines for Field Efficacy Testing of Pesticides, Part 14: Control of Rice Damping-off with Fungicides, control tests for rice damping-off were conducted on Examples 28-36 and Comparative Examples 5-6. The test index was the control effect, expressed as a percentage (%). The test results are shown in Table 5.

[0092] Table 5. Control effect of rice seedling blight Prevention and control efficacy (%) Prevention and control efficacy (%) Example 28 75.3 Example 35 57.3 Example 29 65.2 Example 36 56.4 Example 30 66.7 Example 41 55.3 Example 31 57.6 Example 42 56.7 Example 32 56.9 Comparative Example 5 52.1 Example 33 60.4 Comparative Example 6 53.4 Example 34 62.1 Based on Tables 1 and 5, Examples 28–36 are analyzed: Comparing Examples 28 and 29-32, the control effect of pesticide in Example 28 was greater than that of pesticide in Example 29-30, and the control effect of pesticide in Example 29-30 was greater than that of pesticide in Example 31-32.

[0093] The difference between Examples 28, 29-30 and 31-31 is that the mass ratio of azoxystrobin to fluopyram in Examples 28-30 is (1:5) to (5:1), while the mass ratio of azoxystrobin to fluopyram in Example 28 is 2:1. When the mass ratio of azoxystrobin to fluopyram is (1:5) to (5:1), azoxystrobin and fluopyram can have a synergistic effect. It can be seen that the mass ratio of azoxystrobin to fluopyram is (1:5) to (5:1), which is better, and the mass ratio of azoxystrobin to fluopyram is 2:1, which is better within this range.

[0094] Comparing Examples 28 and 33-36, the disease difference in the pesticide test field of Example 4 was greater than that in the pesticide test fields of Examples 33-36, and the disease difference in the pesticide test fields of Examples 33-34 was greater than that in the pesticide test fields of Examples 35-36.

[0095] The difference between Examples 28, 33-34, and 35-36 is that in Examples 4 and 33-34, the combined mass of azoxystrobin and fluopyram accounts for 0.1% to 5% of the total pesticide mass, while in Example 28, the combined mass of azoxystrobin and fluopyram accounts for 1.5% of the total pesticide mass. Within this range, the combined effect of azoxystrobin and fluopyram is better. It can be seen that a combined mass of azoxystrobin and fluopyram accounting for 0.1% to 5% of the total pesticide mass is preferred, and within this range, a combined mass of azoxystrobin and fluopyram accounting for 1.5% of the total pesticide mass is preferred.

[0096] Based on Tables 1, 3-5, the following analyses are conducted on Examples 1, 13, 25, and Comparative Examples 1-6: Compared with Example 1 and Comparative Examples 1-2, the difference in diseased plants in the pesticide test field of Example 1 was greater than that in the pesticide test field of Example 1-2; compared with Example 13 and Comparative Examples 3-4, the difference in diseased plants in the pesticide test field of Example 13 was greater than that in the pesticide test field of Example 3-4; compared with Example 25 and Comparative Examples 5-6, the difference in diseased plants in the pesticide test field of Example 25 was greater than that in the pesticide test field of Example 5-6.

[0097] The difference between Example 1 and Comparative Example 1 is that silicon dioxide was added in Example 1; the difference between Example 1 and Comparative Example 2 is that calcium oxide was added in Example 1; the difference between Example 13 and Comparative Example 3 is that silicon dioxide was added in Example 13; the difference between Example 13 and Comparative Example 4 is that calcium oxide was added in Example 13; the difference between Example 25 and Comparative Example 5 is that silicon dioxide was added in Example 25; the difference between Example 25 and Comparative Example 6 is that calcium oxide was added in Example 25. Silicon dioxide particles fill the gaps between particles, improving the flowability of the powder. In soil treatment, it can neutralize acidic soil and optimize the activity of azoxystrobin in the rhizosphere environment. Calcium oxide enhances the penetration efficiency of azoxystrobin against soil-borne pathogens. Calcium oxide is converted into calcium peroxide, releasing reactive oxygen species that oxidize the proteins and DNA of pathogens, forming a dual killing effect with the respiratory inhibition mechanism of azoxystrobin. Therefore, the addition of silicon dioxide and calcium oxide is necessary.

[0098] The following analyses are conducted using Tables 2-5: Examples 4, 16, 28, and 37-42. The retention rate after hot storage in Example 4 was greater than that after hot storage in Examples 37-38, and the difference in diseased plants in the field efficacy test of ginger stem base rot in Example 4 was smaller than that in the field efficacy test of ginger stem base rot in Examples 37-38. The difference between Example 4 and Examples 37-38 is that in Example 4, the mass ratio of azoxystrobin, fluazinam, silica, calcium oxide, cashew phosphate, and rosmarinic acid is 1:0.5:0.1:0.05:0.05:0.1; it can be seen that the mass ratio of azoxystrobin, fluazinam, silica, calcium oxide, cashew phosphate, and rosmarinic acid is 1:0.5:0.1:0.05:0.05:0.1.

[0099] The retention rate after hot storage in Example 16 was greater than that after hot storage in Examples 39-40, and the difference in diseased plants in the field efficacy test of peanut white mold in Example 16 was less than that in the field efficacy test of peanut white mold in Examples 39-40. The difference between Example 16 and Examples 39-40 is that in Example 16, the mass ratio of azoxystrobin, prothioconazole, silica, calcium oxide, cashew phenolic phosphate, and rosmarinic acid is 1:0.5:0.1:0.05:0.05:0.1; it can be seen that the mass ratio of azoxystrobin, prothioconazole, silica, calcium oxide, cashew phenolic phosphate, and rosmarinic acid is 1:0.5:0.1:0.05:0.05:0.1.

[0100] The retention rate after hot storage in Example 28 was greater than that after hot storage in Examples 41-42, and the control effect of rice damping-off disease in Example 28 was greater than that in Examples 41-42. The difference between Example 28 and Examples 41-42 is that in Example 4, the mass ratio of azoxystrobin, fluopyram, silica, calcium oxide, cashew phosphate, and rosmarinic acid was 1:0.5:0.1:0.05:0.05:0.1; it can be seen that the mass ratio of azoxystrobin, fluopyram, silica, calcium oxide, cashew phosphate, and rosmarinic acid of 1:0.5:0.1:0.05:0.05:0.1 is preferred.

[0101] This specific embodiment is merely an explanation of the present invention and is not intended to limit the present invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but as long as they are within the scope of protection claimed by the present invention, they are protected by patent law.

Claims

1. A compound composition containing pyraclostrobin, characterized in that, It includes the following components in parts by weight: Component A 5-15 parts, Component B 1-75 parts, and additives. Component A is azoxystrobin; Component B is one of fluazinam, prothioconazole, and fluazinam; The additives include 0.5 to 1.5 parts of silicon dioxide and 0.2 to 0.6 parts of calcium oxide.

2. The compound composition containing pyraclostrobin according to claim 1, characterized in that, The mass ratio of component A to component B is (1:5) to (5:1).

3. The compound composition containing pyraclostrobin according to claim 1, characterized in that, It also includes 0.3 to 0.6 parts of cashew phenolic phosphate.

4. The compound composition containing pyraclostrobin according to claim 3, characterized in that, The catalyst used in the preparation of cashew phenolic phosphate is titanium tetrachloride.

5. The compound composition containing pyraclostrobin according to claim 4, characterized in that, It also includes 0.5 to 1.5 parts of rosmarinic acid.

6. The compound composition containing pyraclostrobin according to any one of claims 1 to 5, characterized in that, It can be used to control ginger stem base rot, peanut white mold, or rice damping-off.

7. A pesticide, characterized in that, It is obtained by mixing the compound composition containing pyraclostrobin according to any one of claims 1 to 6 with a carrier.

8. A pesticide according to claim 8, characterized in that, Components A and B account for 0.1% to 5% of the total mass of the pesticide.

Images