External medicinal liquor as well as preparation method and application thereof in preparation of medicines for treating cold-dampness diseases and sequelae of cold-dampness diseases
By using a method for preparing external medicinal wine, and by combining and processing specific Chinese herbal components with baijiu (Chinese liquor), the technical problems of low safety, cost, and efficiency in the treatment of cold-dampness epidemic diseases and their sequelae have been solved. In particular, by precisely addressing the issues of low safety, cost, and efficiency in the treatment of cold-dampness epidemic diseases and their sequelae, the method has achieved the effect of rapidly relieving symptoms and reducing risks.
Patent Information
- Application Number
- CN202511737494.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-25
- Publication Date
- 2026-01-02
AI Technical Summary
Existing methods for treating cold-dampness epidemic diseases and their sequelae have problems such as insufficient safety, high cost and slow onset of action. In particular, oral medications have the risk of adverse reactions, fire therapy is complicated and dangerous, and the preparation cost of medicinal wine rubbing therapy is high, the cycle is long and the penetration efficiency is low.
A topical medicinal wine containing a specific ratio of traditional Chinese medicine components and liquor is prepared through precise screening and scientific formulation, combined with graded pulverization, vacuum activation treatment, and short-term soaking. This results in a safe, cost-effective, and rapidly effective medicinal wine for local treatment.
It achieves a whole-body coverage network for dispelling cold and dampness, quickly relieves acute symptoms, reduces the risk of sequelae, and reduces the occurrence of sequelae through precise dispelling of cold and dampness epidemic diseases and their sequelae, shortens the treatment cycle, reduces preparation costs, and improves safety and penetration efficiency.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of external use of traditional Chinese medicine medicinal liquor, and particularly relates to an external use medicinal liquor, a preparation method thereof and application of the external use medicinal liquor in preparation of a medicinal liquor for cold-damp epidemic disease and its sequelae. BACKGROUND
[0002] Cold-damp epidemic disease is an epidemic disease caused by invasion of cold-damp evil into the human body and blockage of meridians and blood circulation. Its onset is often related to factors such as cold and humid climate and deficiency of body resistance. Common symptoms include chill, fever, cough, sore throat, olfactory dysfunction, gustatory dysfunction, limb soreness, joint flexion and extension difficulty, fatigue and lethargy, and white and greasy tongue fur. The disease is prone to prolonged and repeated, and if not treated in time or not completely, it often leaves various sequelae such as pharyngitis, pulmonary nodules, olfactory dysfunction, gustatory dysfunction, cold pain in joints, limb numbness and stiffness, muscle soreness and spasm, and limited activity. Therefore, effective treatment of cold-damp epidemic disease and its sequelae has important clinical significance and application value.
[0003] At present, the treatment methods for cold-damp epidemic disease and its sequelae mainly include oral drug treatment and non-drug therapy. Oral drug treatment is the most commonly used treatment method in clinic, including traditional Chinese medicine decoction, Chinese patent medicine and symptomatic treatment drugs. Traditional Chinese medicine treatment is mainly based on the principle of warming yang, dispelling cold and dampness, and dredging collaterals, and adjusting the body's qi, blood, yin and yang by combining related traditional Chinese medicines. Western medicine is mainly used for symptomatic treatment such as relieving fever and pain, and anti-inflammatory and detumescence. However, oral drugs need to be absorbed by the gastrointestinal tract, metabolized by the liver and excreted by the kidney. Some drugs may irritate the mucosa of the gastrointestinal tract, and there is a certain risk of adverse reactions. In addition, some patients have poor tolerance to oral drugs due to differences in constitution or combined with underlying diseases. At the same time, the onset of drugs needs to go through the metabolism in the body, and the targetedness for the relief of local symptoms is insufficient. Non-drug therapy is widely used in the treatment of cold-damp epidemic disease and its sequelae due to its direct effect on the lesion and less adverse reactions, which mainly includes fire therapy and medicinal liquor rubbing therapy.
[0004] The specific operation method of fire therapy is to evenly apply alcohol on the wet towel on the skin surface of the affected area, and then heat it. The alcohol used is usually 95% pure, and 75% alcohol is used for allergic patients. The heat generated by the burning alcohol is used to act on the local area in order to dredge the meridians, dispel cold and dampness. However, the alcohol used in this method has a high burning degree, and is directly applied on the surface of the towel. If not careful during operation, it may cause fire. At the same time, the high temperature generated by burning can easily cause skin burns and scalds, which requires high standardization of operation and has high risk, which is not conducive to daily application.
[0005] The specific operation method of the medicinal liquor rubbing therapy is as follows: more than 20 kinds of traditional Chinese medicines are selected as raw materials, mixed with liquor, white vinegar (or liquor, alcohol) and soaked for more than 6 months, and then the medicinal liquor is obtained by filtering out the medicinal dregs, and the medicinal liquor is directly rubbed on the local lesion. Although this therapy can play a role through external use of drugs, it still has obvious shortcomings. The types of raw materials are various, and the soaking time is as long as more than 6 months, resulting in high cost and long period of medicinal liquor preparation; at the same time, the effective components of the drugs need to be precipitated after long-term soaking, and the penetration efficiency of external use is limited, so that the therapy has slow effect and long treatment course, and it is difficult to quickly relieve the discomfort of the patient; alcohol has many damages to the skin, such as destroying sebum, causing dryness, irritating the skin, damaging the barrier, weakening the elasticity, and possibly causing allergic reactions and other damages such as conjunctival damage.
[0006] In summary, among the existing treatment methods for cold-damp epidemic diseases and their sequelae, the oral drugs have adverse reaction risks and tolerance problems, the fire therapy has high operation risk and insufficient safety, and the medicinal liquor rubbing therapy has defects such as high preparation cost, long time, slow effect, etc. Therefore, developing a safe, simple, cost-effective and rapid-acting external treatment method to effectively improve the symptoms of cold-damp epidemic diseases and their sequelae has become a technical problem to be solved. SUMMARY
[0007] In order to solve the problems of insufficient safety, high cost and slow effect of the existing treatment methods for cold-damp epidemic diseases and their sequelae, the present application provides an external medicinal liquor and its preparation method and application in the preparation of drugs for cold-damp epidemic diseases and their sequelae.
[0008] The technical scheme of the present application is as follows: The present application provides an external medicinal liquor, which comprises the following components in mass fraction: Longxuejie 10-70 parts, Mahuang 10-70 parts, Guizhi 10-70 parts, Honghua 10-70 parts, Chuanxiong 10-70 parts, Chishao 10-70 parts, Baishao 10-70 parts, Lulutong 10-70 parts, Qifeng 10-70 parts, Lianqiao 10-70 parts, Baihuashacai 10-70 parts, Duhuo 60-120 parts, Qianghuo 60-120 parts, Danshen 60-120 parts, Baijiu 40000-60000 parts; The alcohol content of the liquor is 60-80%.
[0009] The present application also provides a preparation method of the above-mentioned external medicinal liquor, comprising the following steps: (1) dry each traditional Chinese medicine component to a water content of ≤8%, and crush, then put into a three-dimensional motion mixer to mix, to obtain a mixed traditional Chinese medicine powder; (2) add 5-8% of liquor by mass to the mixed traditional Chinese medicine powder, stir uniformly and then place in a vacuum drying oven for activation treatment; (3) Put the activated mixed traditional Chinese medicine powder into the remaining liquor, cover and seal, soak for 7 days, filter the residues to obtain the external use medicinal liquor.
[0010] Preferably, the crushing treatment in step (1) is specifically: crushing notopterygium, notopterygium, salvia miltiorrhiza to 100-120 mesh, crushing dragon's blood, ephedra, cassia twig, safflower, chuanxiong, red peony root, white peony root, luyetong, tribulus terrestris to 120-150 mesh, crushing forsythia, lecanorchis to 150-200 mesh.
[0011] Preferably, the rotation speed of the mixing in step (1) is 30-50 r / min, and the mixing time is 15-20 min.
[0012] Preferably, the activation treatment in step (2) is specifically: Under the conditions of vacuum degree-0.06-0.08 MPa and temperature 40-45℃, treating for 2-3 h.
[0013] The application also provides an application of the above-mentioned external use medicinal liquor, which is applied to the preparation of cold-damp epidemic disease and its sequelae drugs.
[0014] The application also provides an application method of the above-mentioned external use medicinal liquor, which comprises the following steps:
[0015] Preferably, the application method specifically comprises the following steps: S1, injecting the external use medicinal liquor into the container and igniting, so that the burning area of the medicinal liquor contacts the palm with the prepared supplies, until the palm area presents a continuous burning effect; S2, aiming the palm at the container containing the medicinal liquor and exerting force from top to bottom, so that the medicinal liquor on the surface which does not reach a stable burning state is separated from the palm and flows back to the container; S3, when the medicinal liquor attached to the palm maintains a burning state, taking acupoints as points, meridians as lines, and spleen acupoint as the starting point, extending downward to eight liao acupoints along the body surface, and then returning upward to the spleen acupoint, and repeating the process until the medicinal liquor on the palm area burns out naturally; S4, when the medicinal liquor attached to the palm maintains a burning state, acting on the body surface in a rhythmic tapping manner until the whole body feels slightly hot and the whole body feels slightly hot, and then stopping; S5, according to the dosage of the external use medicinal liquor, stewing fire until the body surface of the affected person appears slight sweat, and ending the medicinal liquor application process.
[0016] Preferably, the stewing time in step S6 is 5 min / 250 mL of external use medicinal liquor.
[0017] The pharmacological effects of the traditional Chinese medicine components used in the application are as follows: Dragon's Blood: sweet, bitter, salty, nature. Spleen, lung, kidney. Activating blood stasis, pain, stop bleeding, astringent wound healing.
[0018] Ephedra: bitter, slightly bitter, warm. Lung, urinary bladder. Sweating, heat, diuretic, swelling.
[0019] Cassia twig: bitter, sweet, warm. Heart, lung, urinary bladder. Sweating, muscle, warm, Yang, gas, flat, gas.
[0020] Safflower: bitter, warm. Heart, liver. Activating blood stasis, dredging collaterals, swelling and pain.
[0021] Chuanxiong: bitter, warm. Liver, gallbladder, pericardium. Qi, depression, wind, wet, blood, pain.
[0022] Red peony root: bitter, slightly cold. Liver. Clearing heat, cooling blood, stasis pain.
[0023] White peony root: sweet, sour, bitter, slightly cold. Liver, spleen. Nourishing blood, regulating menstruation, astringent, softening the liver, pain, liver Yang.
[0024] Liujiutong: bitter, nature. Liver, kidney. Wind, water, swelling, lactation.
[0025] Caltrops: bitter, slightly warm. Liver. Liver, blood, wind, eyes, itching.
[0026] Forsythia: bitter, cool. Heart, liver, gallbladder. Heat, detoxification, dispersion, swelling.
[0027] White flower snake grass: bitter, cold. Stomach, large intestine, small intestine. Heat, detoxification, swelling, wet, urinary tract.
[0028] Angelica pubescens: bitter, slightly warm. Kidney, urinary bladder. Wind, damp, pain.
[0029] Notopterygium: bitter, warm. Urinary bladder, kidney. Cold, damp, pain.
[0030] Salvia miltiorrhiza: bitter, slightly cold. Heart, liver. Blood, stasis, pain, heart, liver, swelling.
[0031] White wine: sweet, bitter, warm, heart, liver, spleen. Blood, wind, cold, drug.
[0032] Compared with the prior art, the specific beneficial effects of the present application are: The application realizes efficient superposition in warming meridians, expelling wind and dampness, promoting blood circulation and removing blood stasis, etc., while taking into account the safety of drug use, by accurately screening traditional Chinese medicine components and scientifically compounding, and each component forms a synergistic effect based on its own pharmacological properties.
[0033] Specifically, Qiangluo is pungent and warm and rises, and is good at dispelling upper body wind, cold and dampness, especially at relieving neck and shoulder pain, headache and heaviness caused by cold and dampness; Duhuo is slightly warm and descends, and is good at attacking lower body wind and dampness; the two are used together to form a network of expelling cold and dampness covering the whole body.
[0034] Mahuang is pungent and warm and opens, and belongs to the lung and bladder meridians, and can open the pores and clear the orifices, providing an outlet for cold and dampness; Guizhi is sweet and warm and warms yang, and can help Mahuang to enhance the ability to dispel the exterior, and also warm the meridians to dispel cold stagnation in the deep meridians, avoiding stagnation of cold evil. With the help of Chuanxiong, which is pungent and warm and moves qi, the effect of expelling cold and dampness is achieved by the action of wetness and cold, and the warm and dispelling effect is evenly distributed along the meridians, quickly relieving the core symptoms of acute stage such as aversion to cold, no sweating, and heavy limbs, reducing the risk of sequelae from the source.
[0035] Longxuejie belongs to the heart, lung and kidney meridians, and has the functions of promoting blood circulation and removing blood stasis and pain relief, and can specifically relieve joint pain caused by cold and dampness and stasis; Honghua is good at promoting blood circulation and removing blood stasis, and its effect directly acts on the nodes of meridian obstruction, and cooperates with the effect of Chuanxiong in moving qi and relieving pain to solve the vicious cycle of cold stagnation, qi stagnation, and stasis; Danshen not only promotes blood circulation and removes blood stasis, but also clears heat, balancing the warm nature of the prescription, and avoiding heat caused by long-term stasis. Lulutong can dispel wind and activate collaterals, and can guide the components of promoting blood circulation and removing blood stasis to the joints and bones, further dredging the meridians blocked by cold and dampness and stasis, effectively improving the sequelae of numbness and joint stiffness, and restoring the function of limb movement.
[0036] Baishao is sweet and slightly cold, and belongs to the liver and spleen meridians, and can nourish blood and Yin, and soothe the liver and relieve pain, and can restrict the dispersing nature of pungent and warm drugs such as Mahuang and Guizhi, preventing the consumption of blood and qi when expelling cold and dampness; Chishao is bitter and slightly cold, and can clear heat and cool blood, and disperse stasis and relieve pain, and together with Baishao, it can not only enhance the effect of removing blood stasis, but also protect Yin and blood, and reduce the irritation to the skin when used externally. Lianqiao and Baihuashacai are cool, but the amount and warm nature of the drugs balance each other, and can remove the trace of heat evil caused by the stagnation of cold and dampness, avoid the new discomfort caused by the stagnation of cold and dampness, and adapt to the need of expelling evil in the acute stage, and can also be used for long-term conditioning in the sequelae stage, expanding the application scenarios.
[0037] Liquor is the long of all medicines, and can be used as a carrier and core medicine. It is warm in nature and returns to the heart, liver and spleen meridians. It can activate blood and dredge collaterals, dispel wind and cold, and directly echo the efficacy of the core components. At the same time, by virtue of the solvent properties of alcohol, the effective components in each component can be fully dissolved through activation during the preparation of medicinal liquor, and the efficacy can be improved. The volatility and penetration of liquor can accelerate the percutaneous absorption of medicinal components, and the components of warming and dispelling cold and dampness, activating blood and removing blood stasis can quickly penetrate the skin, muscle, viscera and bone, and directly reach the diseased parts of joints and collaterals, solving the problem of slow and deep effect of traditional external medicines. Especially for deep cold and dampness and blood stasis in the sequelae period, the penetration of liquor can make the efficacy more accurately act on the lesion, shorten the conditioning period.
[0038] The present application only uses 14 kinds of traditional Chinese medicines, and the cost is reduced. The liquor brewed from grains is used, and after soaking the traditional Chinese medicines, the ignition point of the medicinal liquor is low, the liquor fire can be extinguished by hand, there is no fire hazard, and there is no case of burn and scald, which is safe. The soaking time is short, only 7 days, which saves the preparation time. The preparation process is simple, only 4 steps from drying and crushing, activation treatment, soaking to filtration, which saves energy and labor cost. And the course of treatment is short and effective. DETAILED DESCRIPTION
[0039] In order to make the technical scheme of the present application clearer, the technical scheme in the embodiments of the present application will be described clearly and completely below. It should be noted that the following embodiments are only used to better understand the technical scheme of the present application, and should not be construed as a limitation of the present application.
[0040] Example 1. The raw material components and quality of this embodiment are as follows: Dragon's blood 300g, Ephedra 300g, Cinnamomum 300g, Safflower 300g, Chuanxiong 300g, Red peony root 300g, White peony root 300g, Herba rhamnus 300g, Tribulus terrestris 300g, Forsythia 300g, White flower snake grass 300g, Angelica pubescens 800g, Notopterygium 800g, Salvia miltiorrhiza 800g, 500000g of liquor; the alcohol content of the liquor is 70%vol.
[0041] The specific preparation process is recorded as follows: (1) The above-mentioned traditional Chinese medicine components are respectively placed in a 40℃ hot air drying oven and dried to a moisture content of 7%, and then classified and crushed: Angelica pubescens, Notopterygium and Salvia miltiorrhiza are crushed to 110 mesh fine powder; Dragon's blood, Ephedra, Cinnamomum, Safflower, Chuanxiong, Red peony root, White peony root, Herba rhamnus and Tribulus terrestris are crushed to 130 mesh fine powder; Forsythia and White flower snake grass are crushed to 180 mesh fine powder. All the fine powder of traditional Chinese medicine meeting the particle size requirement is put into a three-dimensional motion mixer and mixed at a speed of 40r / min for 18min to obtain uniformly mixed mixed traditional Chinese medicine powder.
[0042] (2) Take 6% of the total mass of the mixed traditional Chinese medicine powder of the white spirit, add it to the mixed traditional Chinese medicine powder, and quickly stir until there is no dry powder. Then, place it in a vacuum drying oven, and activate it under the conditions of a vacuum degree of -0.07 MPa and a temperature of 42°C for 2.5 hours to obtain the activated traditional Chinese medicine powder.
[0043] (3) Put the activated traditional Chinese medicine powder into the remaining white spirit, pour it into a ceramic wine barrel with a sealed lid, stir to immerse the traditional Chinese medicine powder completely, tightly seal the lid, and place it in a cool and ventilated place at 25°C for 7 days of soaking. After soaking, first remove the large particles of medicinal residues with a 200-mesh filter screen, then fine filter with a 0.45-μm filter membrane, and collect the filtrate as the external use medicinal wine.
[0044] Example 2 The raw material components and mass of this example are as follows: Dragon's blood 500 g, Ephedra 500 g, Cinnamon Twig 500 g, Safflower 500 g, Chuanxiong 500 g, Red Peony Root 500 g, White Peony Root 500 g, Herba Rorippae 500 g, Forsythia 500 g, White Flower Snake Grass 500 g, Angelica Pubescentis 1000 g, Notopterygium 1000 g, Salvia Miltiorrhiza 1000 g, and white spirit 450000 g. The alcohol content of the white spirit is 65%vol.
[0045] The specific preparation process is as follows: (1) Dry each traditional Chinese medicine component in a 38°C hot air drying oven until the moisture content is 6%, and then perform grading pulverization: pulverize Angelica Pubescentis, Notopterygium, and Salvia Miltiorrhiza to 100-mesh fine powder; pulverize Dragon's blood, Ephedra, Cinnamon Twig, Safflower, Chuanxiong, Red Peony Root, White Peony Root, Herba Rorippae to 120-mesh fine powder; and pulverize Forsythia and White Flower Snake Grass to 150-mesh fine powder. Put all the traditional Chinese medicine fine powder into a three-dimensional motion mixer, mix for 16 minutes at a speed of 35 r / min, and obtain mixed traditional Chinese medicine powder with uniform mixing.
[0046] (2) Take 5% of the total mass of the mixed traditional Chinese medicine powder of the white spirit, add it to the mixed traditional Chinese medicine powder, stir evenly, and then place it in a vacuum drying oven. Activate it under the conditions of a vacuum degree of -0.06 MPa and a temperature of 43°C for 2 hours to obtain the activated traditional Chinese medicine powder.
[0047] (3) Add the activated traditional Chinese medicine powder to the remaining white spirit, pour it into a stainless steel sealed wine barrel, stir evenly, seal, and place it in a 23°C environment for 7 days of soaking. After soaking is complete, filter the residue through a 180-mesh filter screen, then remove the small impurities by centrifugal separation (speed of 3000 r / min, time of 10 min), and collect the supernatant as the external use medicinal wine.
[0048] Example 3 The raw material components and mass of this example are as follows: Dragon's blood 200g, Ephedra 200g, Cinnamomum 200g, Safflower 200g, Chuanxiong 200g, Red peony root 200g, White peony root 200g, Rosin 200g, Tribulus terrestris 200g, Forsythia 200g, White flower snake grass 200g, Duhuo 700g, Notopterygium 700g, Salvia miltiorrhiza 700g, White liquor 550000g; the alcohol content of the white liquor is 75%vol.
[0049] (1) Each traditional Chinese medicine component is placed in a 42℃ hot air drying oven and dried until the moisture content is 5%, and then classified and crushed: Duhuo, Notopterygium, and Salvia miltiorrhiza are crushed to 120 mesh fine powder; Dragon's blood, Ephedra, Cinnamomum, Safflower, Chuanxiong, Red peony root, White peony root, Rosin, and Tribulus terrestris are crushed to 150 mesh fine powder; Forsythia and White flower snake grass are crushed to 200 mesh fine powder. All the fine powder of traditional Chinese medicine is put into a three-dimensional motion mixer and mixed at a speed of 45r / min for 19min to obtain mixed traditional Chinese medicine powder.
[0050] (2) Activation of mixed traditional Chinese medicine powder: 8% of the total mass of mixed traditional Chinese medicine powder of white liquor is added to the mixed traditional Chinese medicine powder, and after being fully stirred to a uniform state, it is placed in a vacuum drying oven and activated at a vacuum degree of-0.08MPa and a temperature of 44℃ for 3h to obtain activated traditional Chinese medicine powder.
[0051] (3) Soaking and preparation of finished product: The activated traditional Chinese medicine powder is put into the remaining white liquor, and is injected into a sealed wine tank with a stirring device. The stirring device is turned on for 5min to mix the materials uniformly. After sealing, it is placed in a 27℃ light-proof environment for 7 days of soaking. After soaking, it is sequentially filtered through a 200 mesh filter screen and a 0.3μm ceramic membrane, and the filtrate is collected to obtain the external use medicinal liquor.
[0052] Effect example The external use medicinal liquor is prepared according to the formula and process described in Example 1, and the patient is treated in the following manner: Prepare the supplies: external use medicinal liquor, container, pure cotton gloves, disposable plastic gloves, disposable bed sheet, towel, and physiotherapy clothes.
[0053] Dip the fire: after wearing the supplies, ignite the external use medicinal liquor in the container, separate the five fingers of the palm with the flame, and gently dip the palm with the ignited external use medicinal liquor until there is fire in the palm.
[0054] Shake the fire: after the palm is brought with fire, the qi of the dantian is poured into the palm, from top to bottom, aiming at the container, and instantly exerting force to shake out the excess external use medicinal liquor on the palm.
[0055] Burn the fire: the palm is like a hawk's claw, and when burning the fire, the five fingers are opened and slightly bent to relax, from the Spleen Shu point to the eight liao points, and then back to the Spleen Shu point, repeatedly, until the fire in the palm is extinguished. If standing on the left body position, burn the fire from the left side of the patient to the right side; if standing on the right body position, burn the fire from the right side of the patient to the left side.
[0056] Fire: with the rhythm of the way, the drug, wine, fire, heat directly to the lesion, wine, fire, and continue to fire, until the big, wind door, spleen, kidney, eight points, such as the body feel performance for the whole hot, can stop fire, start to simmer.
[0057] Fire: the use of heat to exchange the cold and damp in the body outside, cold and damp in the form of water, the use of time according to the amount of external use of medicine wine, the use of medicine wine on the back of 3-6 bottles, 250ml / bottle. The heavier the cold and damp, the more the use of external use of medicine wine, the longer the simmering time, every 250ml / bottle 5 minutes, simmering time is generally in 15-30 minutes; After simmering, the patient with a little sweat is the best, cold and damp in the form of water in the body, will not cause burns, burns and other conditions.
[0058] The following gives the clinical experimental data.
[0059] 1. Clinical data: Of the 100 cases, 44 were male and 56 were female, aged 2 to 92 years, with a course of 3 months to 70 years. 2. Efficacy criteria: Recovery: symptoms and signs basically subsided, efficacy index ≥ 90%; Marked effect: symptoms and signs were significantly reduced, and the efficacy index was 60%-89%; Effective: symptoms and signs improved, and the efficacy index was 5%-59%; No effect: no significant improvement in symptoms and signs, and the efficacy index was <5%.
[0060] 3. Treatment method: The external use of medicine wine acts on the dermis, 250ml-1500ml is taken each time according to the patient's symptoms, the external use of medicine wine is ignited, the palm is dipped in fire, and the fire is burned on the skin of the human body (fire), fire, and fire, once a day, 7 days for a course of treatment.
[0061] 4. Treatment results: After statistics, of the 100 patients in this group, 50 (50.0%) had a significant effect, 49 (49.0%) were effective, and 1 (1.0%) was ineffective, with a total effective rate of 99.0%.
[0062] 5. Typical cases: (1) Female, 55 years old, cold and damp epidemic, body temperature 36.7-37.2 degrees, hot hands and cold feet, clear rhinorrhea, waist pain, after using the external use of medicine wine according to the application method of the invention, the cold sweat, the feet warm, the waist pain relieved after 1 time of treatment, the symptoms were cured after 3 times of treatment. No recurrence was found after 1 week of follow-up.
[0063] (2) Female, 46 years old, cold and damp post-epidemic sequelae, lung nodules, mental depression, aversion to cold, dry cough and other symptoms for half a year, and long-term treatment, chest CT report on December 13, 2023 showed multiple ground glass nodules in both lungs, larger ones in the left upper lobe of the lung, about 6mm x 4mm, calcified nodules in the left upper lobe of the lung. After using the external use medicinal liquor of the application, according to the application method, after 1 time of treatment, the whole body perspired, the body felt warm, and the dry cough symptoms were relieved; after 4 times of treatment, the dry cough symptoms disappeared, and the spirit was vigorous; after 8 courses of treatment (2 months), the CT report on August 29, 2024 showed that the right upper lobe of the lung had double ground glass nodules, about 0.4 cm in size, and the left lung was cured, and the spirit was vigorous. After one year of follow-up, there was no recurrence.
[0064] (3) Male, 13 years old, cold and damp post-epidemic sequelae, complained of cold and fatigue after cold, and the treatment effect was very small after taking Chinese medicine. After using the external use medicinal liquor of the application, according to the application method, after 1 time of treatment, the hands and feet were warm, after the second time, the whole body perspired a lot, and the symptoms of aversion to cold disappeared, after the third time, the whole body perspired a little, and the symptoms of fatigue disappeared, and the above symptoms were cured. After 3 months of follow-up, there was no recurrence.
[0065] (4) Male, 2 years old, cold and damp epidemic disease early symptoms, cold, runny nose, cold hands and feet, low fever 37.3 degrees. After using the external use medicinal liquor of the application, according to the application method, after 1 time of treatment, perspiration, ruddy complexion, warm hands and feet, cold symptoms were relieved, less snot, body temperature 36.7 degrees, night fever 38.5 degrees again after perspiration, the next morning body temperature 36.5 degrees, after 1 time of treatment again, ruddy complexion, good mental state, increased urine output, cold cured. After 3 days of follow-up, there was no recurrence.
[0066] (5) Female, 40 years old, influenza A virus infection, dry cough without sputum for more than two weeks, night cough leading to sleepless, cold limbs and fatigue. After using the external use medicinal liquor of the application, according to the application method, after 1 time of treatment, the dry cough symptoms were relieved, the sputum was white and foamy, the night cough symptoms disappeared, the limbs were warm, and the sleep was sound. After 1 time of treatment the next day, the cough symptoms disappeared, the limbs were warm, and the whole body was relaxed, and the patient reported that she had the strength to do housework, and the dry cough was cured. After 7 days of follow-up, there was no recurrence.
[0067] (6) Female, 54 years old, self-reported sweating after wind, neck, shoulder and waist pain, slow movement, and chest pain when breathing. After using the external use medicinal liquor of the application, according to the application method, after 1 time of treatment, the whole body perspired, and the neck, shoulder, waist and chest pain were relieved after continuous perspiration at home. After 1 time of treatment the next day, the amount of perspiration was less than the previous day, and the above symptoms disappeared. After 1 year of follow-up, there was no recurrence.
[0068] Comparative example. More than 20 kinds of traditional Chinese medicines are selected, specifically including: Angelica 200g, Saposhnikovia divaricata 200g, Gentiana 200g, Atractylodes 200g, Cyathula 200g, Eucommia 200g, Taxillus 200g, Acanthopanax 200g, Radix Trigonellae 200g, Sinopodophyllum 200g, Przewaikia 200g, Fraxinus 200g, Notopterygium 200g, Cinnamomum 200g, Ephedra 200g, Carthamus 200g, Chuanxiong 200g, Salvia 200g, Persica 200g, Olibanum 200g, Myrrh 200g, Corydalis 200g; Baijiu 400000g (alcohol content 65%vol), white vinegar 80000g.
[0069] The more than 20 kinds of traditional Chinese medicines are crushed to 2-3 cm, and are put into a ceramic jar, then Baijiu and white vinegar are added, and the materials are preliminarily mixed by stirring 3 times with a bamboo chopstick to ensure that the traditional Chinese medicines are completely immersed in the liquid, the jar opening is sealed, and after being placed in a room temperature environment for 180 days of immersion, the jar is opened, the dregs are removed by filtration, and the filtrate is collected as the finished product of medicinal liquor.
[0070] The patient is treated by the same method as the present application. The results are shown in Table 1 compared with the indicators of the embodiments of the present application.
[0071] Table 1
[0072] Through comparison, it can be determined that the technical advantage of the present application lies in that the number of raw materials is small, the cost is greatly reduced, the preparation efficiency is greatly improved, the market and clinical needs can be quickly responded, the onset speed is improved by more than 60%, the patient's discomfort is quickly improved, and the safety is also significantly improved.
[0073] The present application solves the core defects of the prior art, such as the variety of traditional Chinese medicines, long preparation period and high cost, through the process design of precise components, fractional crushing and vacuum activation. The vacuum activation treatment can destroy the cell wall structure of traditional Chinese medicines, greatly improve the dissolution efficiency of effective components, and achieve high dissolution effect without long-term soaking, the preparation period is shortened from 6 months to less than 10 days, and the cost is significantly reduced. In the components of the present application, Notopterygium and Fraxinus cooperate to expel cold from top to bottom, Dragon's Blood and Carthamus accurately resolve stasis, and Baijiu promotes penetration, so that the effective components quickly penetrate the skin to reach the disease site, the onset time and treatment course are much better than those of the comparative examples; at the same time, the combination of Radix Paeoniae Alba and Radix Paeoniae Rubra enhances the efficacy while reducing skin irritation, and the safety is better, which is completely suitable for the external treatment needs of cold-damp epidemic and its sequelae.
[0074] Obviously, the above embodiments are merely example for clearly illustrating but not limitation to the embodiments. Based on the above description, other different forms of changes or variations can be made by those skilled in the art. Here, all the embodiments need not and can not be enumerated. The obvious changes or variations derived from the above description are still within the protection scope of the present application.
Claims
1. An external medicinal liquor, characterized in that, Comprise the following components by mass fraction: Dragon's blood 10~70 parts, Ephedra 10~70 parts, Cassia twig 10~70 parts, Red flower 10~70 parts, Chuanxiong 10~70 parts, Red peony root 10~70 parts, White peony root 10~70 parts, Lodurton 10~70 parts, Tribulus terrestris 10~70 parts, Forsythia 10~70 parts, White flower snake grass 10~70 parts, Angelica pubescens 60~120 parts, Notopterygium 60~120 parts, Salvia miltiorrhiza 60~120 parts, 40000~60000 parts of white wine; The alcohol content of the white wine is 60~80%.
2. The method for preparing the external medicinal liquor according to claim 1, characterized in that, Comprise the following steps: (1) Dry each traditional Chinese medicine component to a moisture content of ≤8%, and perform a crushing treatment, then put into a three-dimensional motion mixer to mix, to obtain a mixed traditional Chinese medicine powder that is uniformly mixed; (2) Add 5~8% of white wine by mass to the mixed traditional Chinese medicine powder, stir uniformly, and then place in a vacuum drying oven for activation treatment; (3) Put the activated mixed traditional Chinese medicine powder into the remaining white wine, cover and seal, soak for 7 days, filter out the medicinal dregs, and obtain an external use medicinal wine.
3. The preparation method of the external medicinal liquor according to claim 2, characterized in that, The crushing treatment in step (1) is specifically: crush Angelica pubescens, Notopterygium, and Salvia miltiorrhiza to 100~120 mesh, crush Dragon's blood, Ephedra, Cassia twig, Red flower, Chuanxiong, Red peony root, White peony root, Lodurton, and Tribulus terrestris to 120~150 mesh, and crush Forsythia and White flower snake grass to 150~200 mesh.
4. The preparation method of the external medicinal liquor according to claim 2, characterized in that, The mixing speed in step (1) is 30~50 r / min, and the mixing time is 15~20 min.
5. The preparation method of the external medicinal liquor according to claim 2, characterized in that, The activation treatment in step (2) is specifically: Treat at a vacuum degree of -0.06~-0.08 MPa and a temperature of 40~45℃ for 2~3 h.
6. The application of a topical medicinal wine as described in claim 1, characterized in that, Applied to the preparation of drugs for cold-damp epidemic diseases and their sequelae.
7. The method of using the external medicine wine according to claim 1, characterized in that, Place the external use medicinal wine in a container and ignite it, and use the palm of a hand wearing a ready-to-use tool to dip the ignited external use medicinal wine and contact it to the body surface.
8. The application method of the external medicinal liquor according to claim 7, characterized in that, The application method specifically comprises the following steps: S1. Inject the external use medicinal wine into a container and ignite it, so that the burning area of the medicinal wine contacts the palm of a hand wearing a ready-to-use tool, until the palm area presents a sustained burning effect; S2. Aim the palm at the container containing the medicinal wine and exert force from top to bottom, so that the medicinal wine that has not reached a stable burning state detaches from the palm and flows back into the container; S3. When the medicinal wine attached to the palm maintains a burning state, take acupoints as points, meridians as lines, and the Spleen Shu acupoint as the starting point, extend along the body surface to the eight liao acupoints, and then return to the Spleen Shu acupoint, and repeat the process in this path until the medicinal wine on the palm area naturally burns out; S4. When the medicinal wine attached to the palm maintains a burning state, apply it to the body surface in a rhythmic tapping manner until the body sensation of each acupoint presents a slight burning and the overall warmth, and then stop; S5. According to the dosage of the external use medicinal wine, smolder until a slight sweat appears on the body surface of the subject, and end the medicinal wine application process.
9. The application method of the external medicinal liquor according to claim 8, characterized in that, The smoldering time in step S6 is 5 min per 250 mL of external use medicinal wine.