Interventional drug sustained release microsphere injection device

Abstract

The invention relates to the technical field of medical instruments, in particular to an interventional drug sustained release microsphere injection device which comprises a base, and a drug pushing mechanism, a drug mixing mechanism, a valve mechanism and a control mechanism are arranged on the base. The medicine pushing mechanism is provided with a medicine pushing injector used for pushing medicine, the medicine mixing mechanism is provided with a medicine storage injector used for temporarily storing the medicine, the valve mechanism comprises a three-way valve and a hose, two connectors of the three-way valve are connected with the medicine pushing injector and the hose respectively, the other connector of the three-way valve is used for being connected with an indwelling catheter, and the hose is connected with the medicine storage injector. By additionally arranging the oscillating mechanism and the control mechanism, the operation is convenient, the medicine storage injector can be oscillated and uniformly mixed, manual shaking is not needed, the medicine pushing injector is repeatedly pushed and drawn, the uniformity of microspheres in the injection is high, the whole interventional treatment time is shortened, and the surgical risk is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to an interventional drug sustained-release microsphere injection device. BACKGROUND

[0002] Interventional drug sustained-release microsphere therapy is a technique in which microspheres are used as embolic agents in chemotherapy, and the microspheres are injected into blood vessels on the basis of angiography to block blood vessels and cut off the supply of nutrients to tumors, while releasing chemotherapy drugs to treat tumors. It is widely used in the clinical diagnosis and treatment of malignant tumors, hemangiomas, blood vessels or stenosis and other benign and malignant diseases.

[0003] Generally, two syringes are needed when injecting microspheres, one 10ml syringe and one 1ml syringe. The 10ml syringe is used to configure and store drug-loaded microspheres, liquid medicine and contrast agent. The 10ml syringe and the 1ml syringe are connected by a three-way joint. The 1ml syringe is used to suck the mixed injection liquid from the 10ml syringe, and then inject it into the corresponding blood vessel of the tumor through the three-way joint and the indwelling tube. The 1ml syringe is used for injection because it has small pushing resistance, which is convenient for the doctor to slowly push the medicine and feel the pushing resistance. When the pushing resistance is significantly increased, CT imaging is used to verify whether the blocking of the microspheres in the blood vessel reaches the expected result. Currently, manual operation is mainly used in clinical practice.

[0004] The above injection steps have low automation degree and complicated operation. This is because there is a difference between the density of the drug-loaded microspheres and the injection liquid. The drug-loaded microspheres may be deposited, stratified and aggregated in the 10ml syringe, which affects the uniformity of the drug-loaded microspheres. Therefore, before each time the 1ml syringe is used to extract the injection liquid from the 10ml syringe, the 10ml syringe needs to be shaken in advance, and the 1ml syringe needs to be reciprocally pumped. Water flow is used to impact the drug-loaded microspheres to uniformly disperse them in the injection liquid. This greatly prolongs the time of the entire interventional treatment and increases the risk of surgery. A patent with application number 2025102239123 discloses a remote injection power device for DSA surgery. The existing syringes and catheters used for injecting microspheres and liquid medicine can be directly assembled to the power device, and automation is achieved during the injection process. However, the above-mentioned problem of microsphere uniformity has not been solved, and the overall volume is too large, so there is not much table space in the operating room to place these devices.

[0005] Therefore, it is urgent to provide an interventional drug sustained-release microsphere injection device that is easy to operate and has high microsphere uniformity. SUMMARY

[0006] The present application aims to provide an interventional drug sustained-release microsphere injection device to solve the problems in the background art. The specific technical solution is as follows:

[0007] To achieve the above object and other related objects, the present application provides an interventional drug sustained-release microsphere injection device, comprising a base, a drug pushing mechanism, a drug mixing mechanism, a valve mechanism and a control mechanism are arranged on the base; the drug pushing mechanism is provided with a drug pushing syringe for drug pushing, the drug mixing mechanism is provided with a drug storage syringe for temporarily storing drugs, the valve mechanism comprises a three-way valve and a hose, two interfaces of the three-way valve are connected with the drug pushing syringe and the hose respectively, and the other interface is used for connecting a retention catheter, the hose is connected with the drug storage syringe, the drug mixing mechanism comprises an oscillation mechanism and a first fixing clamp, the oscillation mechanism is arranged on the base, the first fixing clamp is arranged on the oscillation mechanism, the first fixing clamp is used for fixing the drug storage syringe, the oscillation mechanism is used for oscillating and uniformly mixing the drug storage syringe, the hose connection can avoid the oscillation force of the drug storage syringe being transmitted to the three-way valve, and the control mechanism controls the working of the oscillation mechanism.

[0008] Preferably, the base is further provided with a support, and a camera module is arranged on the support, the camera module is used for shooting the side surface of the drug storage syringe, the drug storage syringe is a common syringe made of transparent plastic or transparent glass, the camera module is connected with the control mechanism, the control mechanism receives the image of the camera module and analyzes and judges the uniformity of the microspheres in the drug storage syringe, and the oscillation mechanism is started after the uniformity exceeds a threshold value.

[0009] Preferably, the control mechanism is configured to:

[0010] S1, multiple images of the drug storage syringe after sufficient mixing are shot, the average value of each pixel V channel of the image is calculated through HSV space, and an average reference template is generated;

[0011] S2, the average reference template is grayed, the grayed image is subjected to Gaussian filtering to eliminate random noise interference, and finally edge detection is performed through a Canny algorithm to segment the effective area of the drug storage syringe to establish a reference template;

[0012] S3, the newly shot image of the camera module is identified, and an absolute value difference algorithm is used to compare the difference between the current frame and the reference template pixel by pixel;

[0013] S4, the uniformity of the microspheres in the drug storage syringe is judged by setting a difference value threshold; when the difference value threshold is exceeded, the control mechanism controls the working of the oscillation mechanism.

[0014] Preferably, a hanging assembly is arranged on the base.

[0015] Preferably, the oscillation mechanism comprises a transverse oscillator, a longitudinal oscillator, a connecting frame, the transverse oscillator and the longitudinal oscillator are arranged on the connecting frame, the connecting frame is connected with the first fixed clamp, the transverse oscillator is used to drive the connecting frame to vibrate transversely, the longitudinal oscillator is used to drive the connecting frame to vibrate longitudinally, and the control mechanism is configured to: S5, after judging the uniformity of the microspheres in the drug storage syringe, identifying the position of the microsphere aggregation, and selecting the transverse oscillator or the longitudinal oscillator to work according to the position of the microsphere aggregation.

[0016] Preferably, the connecting frame comprises T-shaped sliders and a slide rod, a sliding groove is formed in the base, the transverse oscillator is arranged in the sliding groove, the transverse oscillator vibrates transversely in the sliding groove, the upper side of the transverse oscillator is provided with a limiting groove, the T-shaped sliders are arranged in the limiting groove, the slide rod is arranged between the two T-shaped sliders, the mover end of the longitudinal oscillator is slidably connected to the slide rod, the T-shaped sliders are fixedly connected with the first fixed clamp, the transverse oscillator drives the T-shaped sliders to realize transverse oscillation of the drug storage syringe on the first fixed clamp, and the longitudinal oscillator transmits the longitudinal oscillation force to the T-shaped sliders through the connecting rod to realize longitudinal oscillation of the drug storage syringe on the first fixed clamp.

[0017] Preferably, the first fixed clamp adopts a U-shaped elastic buckle, and the opening direction of the first fixed clamp is arranged towards the camera module.

[0018] Preferably, the U-shaped elastic buckle is provided with a light supplementing lamp.

[0019] Preferably, the medicine pushing mechanism comprises a second fixed clamp, a lead screw motor assembly, a push block and a cover, the second fixed clamp is arranged on the base, the second fixed clamp is used to clamp the medicine pushing syringe, the lead screw motor assembly is arranged below the second fixed clamp, the push block is arranged on the lead screw motor assembly, the upper side of the push block is provided with a groove for fixing the piston handle of the medicine pushing syringe, the lead screw motor assembly is used to control the movement of the push block, the cover is rotatably installed on the upper side of the push block, the cover is used to fix the upper side of the piston handle, the cover is provided with a pressure sensor, and the pressure sensor is used to monitor the pushing force information.

[0020] Preferably, the valve mechanism further comprises a driving motor, the driving motor is arranged on the base, and a plurality of limiting rods are arranged on the driving motor and used to fix the knob of the three-way valve.

[0021] The intervention drug sustained-release microsphere injection device provided by the application has the following beneficial effects:

[0022] 1. By additionally arranging the oscillation mechanism and the control mechanism, the operation is convenient, the drug storage syringe can be oscillated and uniformly mixed, manual shaking and repeated pushing and pulling of the medicine pushing syringe are not needed, the uniformity of the microspheres in the injection liquid is high, the time of the whole intervention treatment is reduced, and the operation risk is reduced.

[0023] 2. By adding a hanging assembly, the base can be placed flat or hung according to the use environment, and by adding a transverse oscillator, a longitudinal oscillator, a camera module and image processing of the control mechanism, rapid mixing in different postures is realized, a specific oscillation mode is selected according to the gathering position, the mixing speed is fast, the uniformity is good, the oscillation speed and amplitude required for mixing are low, and the integrity of the microspheres can be effectively protected. BRIEF DESCRIPTION OF DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor.

[0025] Figure 1 is a perspective view of the present application;

[0026] Figure 2 is a perspective view after the drug injection and storage injection are removed;

[0027] Figure 3 is Figure 2 is a perspective view from another angle. DETAILED DESCRIPTION

[0028] The present application provides an interventional drug sustained-release microsphere injection device. The advantages and features of the present application will be more apparent from the following description. It should be noted that the drawings are very simplified and use non-precise proportions, only to facilitate and clarify the purpose of assisting the description of the embodiments of the present application.

[0029] In the description of the present application, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is at least two, such as two, three, etc., unless otherwise specifically limited.

[0030] It should be noted that the drawings provided in the following embodiments only illustrate the basic concept of the present application in a schematic manner, and only show the components related to the present application in the drawings, not according to the number, shape and size of the components in actual implementation. The state, number and proportion of each component in actual implementation can be arbitrarily changed, and the layout state of the components can be more complex.

[0031] AsFigures 1-3 As shown in the figure, an interventional drug sustained-release microsphere injection device includes a base 1, a drug pushing mechanism 2, a drug mixing mechanism 3, a valve mechanism 4, and a control mechanism arranged on the base 1. The drug pushing mechanism 2 is provided with a drug pushing syringe 5 for pushing the drug. The drug mixing mechanism 3 is provided with a drug storage syringe 6 for temporarily storing the drug. The valve mechanism 4 includes a three-way valve 41 and a hose 42. Two interfaces of the three-way valve 41 are connected with the drug pushing syringe 5 and the hose 42 respectively, and the other interface is used for connecting a retention catheter. The hose 42 is connected with the drug storage syringe 6. The drug mixing mechanism 3 includes an oscillation mechanism 31 and a first fixing clamp 32. The oscillation mechanism 31 is arranged on the base 1 and provided with the first fixing clamp 32. The first fixing clamp 32 is used for fixing the drug storage syringe 6. The oscillation mechanism 31 is used for oscillating and uniformly mixing the drug storage syringe 6. The hose 42 is connected to avoid the oscillation force of the drug storage syringe 6 being transmitted to the three-way valve 41. The control mechanism controls the working of the oscillation mechanism 31.

[0032] In working, the oscillation mechanism 31 oscillates and uniformly mixes the drug storage syringe 6. The drug pushing syringe 5 is operated by the drug pushing mechanism 2 to extract the mixed injection liquid from the drug storage syringe 6. Generally, the drug pushing syringe 5 is extracted and pushed at least once to make the density of the injection liquid microspheres uniform. After the extraction is completed, the three-way valve 41 is adjusted to make the drug pushing syringe 5 communicate with the retention catheter. The drug pushing syringe 5 is operated by the drug pushing mechanism 2 to slowly push the drug at a predetermined speed.

[0033] In some embodiments, the base 1 is further provided with a support 7, and a camera module 8 is arranged on the support 7, the camera module 8 is used for shooting the side surface of the drug storage syringe 6, the drug storage syringe 6 is a common syringe made of transparent plastic or transparent glass, the camera module 8 is connected with a control mechanism, the control mechanism receives the image of the camera module 8 and analyzes and judges the uniformity of the microspheres in the drug storage syringe 6, and the oscillation mechanism 31 is started when the uniformity exceeds a threshold value, specifically, an analysis and judgment algorithm runs in the control mechanism, the analysis and judgment algorithm takes color depth as the uniformity judgment standard, including: S1, shooting multiple images of the drug storage syringe 6 after sufficient mixing, calculating the average value of each pixel V channel of the image through HSV space, and generating an average reference template; S2, performing grayscale on the average reference template, performing Gaussian filtering on the grayscale image to eliminate random noise interference, and finally performing edge detection through the Canny algorithm to segment the effective area of the drug storage syringe 6 to establish a reference template; S3, identifying the newly shot image of the camera module 8, and using the absolute value difference algorithm to compare the difference between the current frame and the reference template pixel by pixel; S4, judging the uniformity of the microspheres in the drug storage syringe 6 by setting a difference value threshold; when the microspheres float or deposit, the microspheres are mainly concentrated at the top or bottom of the drug storage syringe 6, and the color of the top or bottom of the syringe will deepen; when the microspheres appear to adhere to the wall, the color of the wall of the drug storage syringe 6 as a whole deepens; when the difference value calculated by the absolute value difference algorithm exceeds the threshold value, the control mechanism controls the oscillation mechanism 31 to work, the working frequency of the oscillation mechanism 31 is reduced according to the suspension characteristics of the microspheres, and the problem of damage to the structure of the microspheres caused by excessive oscillation is avoided.

[0034] In some embodiments, the base 1 is provided with a hanging assembly 9, generally, the hanging assembly 9 is a hanging hole, a hook or a lifting ring, in use, the base 1 can be placed flat, or the base 1 can be hung on a support through the hanging assembly 9.

[0035] In some embodiments, the oscillation mechanism 31 comprises a transverse oscillator 311, a longitudinal oscillator 312, a connecting frame provided with the transverse oscillator 311 and the longitudinal oscillator 312, and connected with the first fixed clamp 32; the transverse oscillator 311 is used to drive the connecting frame to vibrate transversely, and the longitudinal oscillator 312 is used to drive the connecting frame to vibrate longitudinally; the connecting frame comprises a T-shaped sliding block 313 and a sliding rod 314; a sliding groove is formed in the base 1, the transverse oscillator 311 is arranged in the sliding groove, and the transverse oscillator 311 vibrates transversely in the sliding groove; a limiting groove is formed in the upper side of the transverse oscillator 311, the T-shaped sliding block 313 is arranged in the limiting groove, the sliding rod 314 is arranged between the two T-shaped sliding blocks 313, the mover end of the longitudinal oscillator 312 is slidably connected to the sliding rod 314, and the T-shaped sliding block 313 is fixedly connected with the first fixed clamp 32; the transverse oscillator 311 drives the T-shaped sliding block 313 to realize transverse oscillation of the drug storage syringe 6 on the first fixed clamp 32; the longitudinal oscillator 312 transmits a longitudinal oscillation force to the T-shaped sliding block 313 through a connecting rod to realize longitudinal oscillation of the drug storage syringe 6 on the first fixed clamp 32; the first fixed clamp 32 is a U-shaped elastic buckle, the opening direction of the first fixed clamp 32 faces the camera module 8, facilitating shooting, avoiding excessive shielding of the surface of the drug storage syringe 6 by the first fixed clamp 32, and a light supplementing lamp 33 is arranged in the U-shaped elastic buckle; and the control mechanism is configured to identify the position of the microspheres after judging the uniformity of the microspheres in the drug storage syringe 6.

[0036] When the base 1 is placed flat on a table top, the position of the microspheres is generally at the bottom or the upper part of the barrel wall, at this time, the longitudinal oscillator 312 is started to oscillate the drug storage syringe 6 up and down to quickly mix; when the base 1 is hung on a support, the position of the microspheres is generally at the syringe nipple end or the piston end, at this time, the transverse oscillator 311 is started to oscillate the drug storage syringe 6 transversely to realize quick mixing in different postures; according to the position of the microspheres, a specific oscillation mode is selected, the mixing speed is fast, the uniformity is good, the oscillation speed and amplitude required for mixing are low, and the integrity of the microspheres can be effectively protected.

[0037] In some embodiments, the drug pushing mechanism 2 comprises a second fixed clamp 21, a lead screw motor assembly 22, a pushing block 23, and a cover 24; the second fixed clamp 21 is arranged on the base, and is used to clamp the drug pushing syringe 5; the lead screw motor assembly 22 is arranged below the second fixed clamp 21; the pushing block 23 is arranged on the lead screw motor assembly 22, and the upper side of the pushing block 23 is provided with a groove for fixing the piston handle of the drug pushing syringe 5; the lead screw motor assembly 22 is used to control the movement of the pushing block 23 to realize automatic drug pushing; the cover 24 is rotatably arranged on the upper side of the pushing block 23, and is used to fix the upper side of the piston handle; a pressure sensor 25 is arranged on the cover 24, and is used to monitor the pushing force information; when the resistance exceeds a threshold value, the drug injection is stopped.

[0038] In some embodiments, the valve mechanism 4 further comprises a driving motor 43 arranged on the base 1, a plurality of limiting rods 44 are arranged on the driving motor 43, the limiting rods 44 are used for fixing the knob of the three-way valve 41, and the driving motor 43 is used for controlling the rotation of the knob to control the communication mode of the three-way valve 41.

[0039] In some embodiments, the control mechanism further comprises a 5G communication module for remote connection with the upper computer, and real-time control or program control of the working of the various electronic elements is realized on the upper computer.

[0040] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application and are not limiting. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced equivalently without departing from the spirit and scope of the technical solutions of the present application.

Claims

1. An interventional drug sustained-release microsphere injection device, characterized in that, The device includes a base, on which are mounted a drug-promoting mechanism, a drug-mixing mechanism, a valve mechanism, and a control mechanism. The drug-promoting mechanism has a drug-promoting syringe for pushing the drug, and the drug-mixing mechanism has a drug-storage syringe for temporarily storing the drug. The valve mechanism includes a three-way valve and a hose. Two ports of the three-way valve are connected to the drug-promoting syringe and the hose, respectively, and the other port is used to connect to an indwelling catheter. The hose is connected to the drug-storage syringe. The drug-mixing mechanism includes a oscillation mechanism and a first fixing clamp. The oscillation mechanism is mounted on the base, and the first fixing clamp is used to fix the drug-storage syringe. The oscillation mechanism is used to oscillate and mix the drug-storage syringe. The hose connection can prevent the oscillation force of the drug-storage syringe from being transmitted to the three-way valve. The control mechanism controls the operation of the oscillation mechanism.

2. The interventional drug sustained-release microsphere injection device according to claim 1, characterized in that, The base is also equipped with a support component, on which a camera module is mounted. The camera module is used to take pictures of the side of the drug-containing syringe. The drug-containing syringe is a commonly used transparent plastic or transparent glass syringe. The camera module is connected to the control mechanism. The control mechanism receives the images from the camera module and analyzes and judges the uniformity of the microspheres in the drug-containing syringe. If the uniformity exceeds the threshold, the oscillation mechanism is activated.

3. The interventional drug sustained-release microsphere injection device according to claim 2, characterized in that, The control mechanism is configured as follows: S1. Take multiple images of the drug-containing syringe after thorough mixing, calculate the average value of the V channel of each pixel in the image using the HSV space, and generate an average reference template. S2. By converting the average reference template to grayscale, Gaussian filtering is applied to the grayscale image to eliminate random noise interference. Finally, edge detection is performed using the Canny algorithm to segment the effective area of ​​the drug-containing syringe and establish the reference template. S3. Recognize the newly captured images by the camera module and use the absolute value difference algorithm to compare the difference between the current frame and the reference template pixel by pixel; S4. By setting a difference threshold, the uniformity of the microspheres in the drug-containing syringe is determined; when the difference threshold is exceeded, the control mechanism controls the oscillation mechanism to work.

4. The interventional drug sustained-release microsphere injection device according to claim 2, characterized in that, The base is equipped with a mounting component.

5. The interventional drug sustained-release microsphere injection device according to claim 4, characterized in that, The oscillation mechanism includes a transverse oscillator, a longitudinal oscillator, and a connecting frame. The connecting frame is equipped with a transverse oscillator and a longitudinal oscillator. The connecting frame is connected to the first fixed clamp. The transverse oscillator is used to drive the connecting frame to vibrate transversely, and the longitudinal oscillator is used to drive the connecting frame to vibrate longitudinally. The control mechanism is configured as follows: S5, after judging the uniformity of the microspheres in the drug-containing syringe, the position of the microsphere aggregation is identified, and the transverse oscillator or the longitudinal oscillator is selected to work according to the position of the microsphere aggregation.

6. The interventional drug sustained-release microsphere injection device according to claim 5, characterized in that, The connecting frame includes a T-shaped slider and a sliding rod. A groove is provided on the base, and a transverse oscillator is set in the groove. The transverse oscillator vibrates transversely in the groove. A limit groove is provided on the upper side of the transverse oscillator, and a T-shaped slider is set in the limit groove. A sliding rod is set between two T-shaped sliders. The moving end of the longitudinal oscillator is slidably connected to the sliding rod. The T-shaped slider is fixedly connected to the first fixed clamp. The transverse oscillator drives the T-shaped slider to achieve transverse oscillation of the drug-containing syringe on the first fixed clamp. The longitudinal oscillator transmits the longitudinal oscillation force to the T-shaped slider through the connecting rod to achieve longitudinal oscillation of the drug-containing syringe on the first fixed clamp.

7. The interventional drug sustained-release microsphere injection device according to claim 6, characterized in that, The first fixing clamp adopts a U-shaped elastic buckle, and the opening of the first fixing clamp is arranged facing the camera module.

8. The interventional drug sustained-release microsphere injection device according to claim 7, characterized in that, A supplementary light is installed inside the U-shaped elastic buckle.

9. The interventional drug sustained-release microsphere injection device according to claim 1, characterized in that, The drug delivery mechanism includes a second fixed clamp, a lead screw motor assembly, a push block, and a cover. The second fixed clamp is mounted on the base and is used to hold the drug delivery syringe. The lead screw motor assembly is located below the second fixed clamp, and the push block is mounted on the lead screw motor assembly. The upper side of the push block has a groove for fixing the piston handle of the drug delivery syringe. The lead screw motor assembly is used to control the movement of the push block. The cover is rotatably mounted on the upper side of the push block and is used to fix the upper side of the piston handle. A pressure sensor is mounted on the cover and is used to monitor the thrust information.

10. The interventional drug sustained-release microsphere injection device according to claim 1, characterized in that, The valve mechanism also includes a drive motor, which is mounted on the base and has multiple limit rods. These limit rods are used to fix the knob of the three-way valve.

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