Preparation method and application of template for particle implantation

Abstract

The invention discloses a preparation method and application of a template for particle implantation, relates to the technical field of radioactive auxiliary equipment, and is characterized in that the template for radioactive particle implantation is provided, and meanwhile, the invention further discloses the preparation method of the template. In addition, the template can also be used for measuring whether dose rate distribution after particle implantation conforms to a preset value or not in actual use, so that whether a particle implantation operation is successful or not is judged. The basic structure of the template comprises a flexible grid plate and a gel layer, the flexible grid plate is made of a rubber material containing bismuth, tungsten and tantalum powder, and the gel layer is made of a fluorescent composite material containing ZnS powder.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of radio-assisted equipment, more particularly, it relates to a preparation method and application of a template for particle implantation. BACKGROUND

[0002] The radioactive particle implantation method is a brachytherapy method used in the medical field for treating tumor patients. This method implants micro radioactive sources into tumors or tissues infiltrated by tumors, uses continuous low-energy gamma rays to destroy tumor tissues, and reduces damage to normal tissues, and can be divided into permanent and non-permanent implantation.

[0003] The treatment implementation needs to be completed by a nuclear medicine physician in conjunction with a clinical department. Before operation, image examination is required to determine the shape, position and relationship with the surrounding structure of the tumor, and a three-dimensional treatment planning system is used to determine the number and distribution of particles. Common implantation methods include template implantation, image-guided implantation and intraoperative implantation. The operation steps cover anesthesia sedation, body position fixation, implant needle positioning and post-implantation environment detection.

[0004] However, the particle implantation template in the prior art cannot intuitively determine whether the operation is successful, and cannot measure the dose rate of the implanted particles. SUMMARY

[0005] The purpose of the present application is to provide a preparation method and application of a template for particle implantation, which can intuitively determine whether the operation is successful, and can also measure the dose rate of the implanted particles.

[0006] The above technical purpose of the present application is achieved by the following technical scheme: a template for particle implantation, the template comprising a flexible grid plate and a gel layer, the flexible grid plate being made of rubber material containing bismuth, tungsten and tantalum powder, and the gel layer being made of fluorescent composite material containing ZnS powder. The rubber made of bismuth, tungsten and tantalum powder has excellent shielding performance for the radiation of implanted radioactive particles, so that the radiation can only be transmitted from the aperture.

[0007] The present application further provides that the grid plate contains a plurality of grids, each grid having a size of 7x7mm-10x10mm, the grid plate having a thickness of 3±0.1mm and a height of 3mm-5mm. The hole plate with a thickness of more than 3mm can make the directionality of the radiation better and remove the influence of radiation scattering.

[0008] The present application further provides a preparation method of the above-mentioned template: the core components of the above-mentioned template are the flexible grid plate and the gel layer, and the preparation method of the rubber material for preparing the flexible grid plate is as follows:

[0009] Mixing rubber with mixed powder of bismuth, tungsten and barium, the ratio of rubber to mixed powder is 1:4, the ratio of bismuth, tungsten and barium in the mixed powder is 2:7:1;

[0010] The preparation method of the fluorescent composite material for preparing the gel layer is as follows:

[0011] The resin is obtained by mixing prepolymer, photoinitiator and diluent, the resin is irradiated by ultraviolet lamp for 5s to make the resin in a gel state; ZnS powder is added into the resin in the gel state, the ratio of ZnS powder to the resin in the gel state is 4:6, and the thickness is not more than 10mm.

[0012] The prepared rubber material and fluorescent composite material are prepared into a flexible grid plate and a gel layer respectively, the implant needle is inserted into the gel layer and passes through the lower grid space in a determined position and angle, and ultraviolet irradiation is carried out for curing; after curing, the implant needle is extracted, and a pore with a fixed direction is left.

[0013] The application of the template in measuring the dose rate of radioactive particles is further provided.

[0014] The application further provides that:

[0015] The method for measuring the dose rate of radioactive particles is as follows:

[0016] The prepared particle implantation template is fixed around the patient's body, the needle hole reserved in the particle implantation template is aligned with the operation position, and a radioactive particle implantation operation is carried out, after the radioactive particles are implanted into the body, the radiation is irradiated to the fluorescent layer after being collimated, and a radiation luminescence pattern is left on the fluorescent layer, after the operation is completed, the success or failure of the operation can be directly judged by comparing the brightness and bright contrast of the pattern, and in the follow-up examination process, the accuracy of the radioactive particle dose or the movement of the particles in the body can also be evaluated according to the shape of the template pattern.

[0017] In summary, the present application has the following advantages: compared with the existing radioactive particle implantation template in the prior art, the present application has good individual applicability, the implant needle is directionally fixed by photocuring, the template can be individually designed, and the time is relatively short. After the radioactive particles are implanted into the body, the radiation is irradiated to the fluorescent layer after being collimated, and a radiation luminescence pattern is left on the fluorescent layer, so that the distance and position of the particles can be known during the operation. After the operation is completed, the success or failure of the operation can be directly judged by comparing the brightness and bright contrast of the pattern, and in the follow-up process, the accuracy of the radioactive particle dose or the movement of the particles in the body can also be evaluated according to the shape of the template pattern. The template manufacturing method not only has excellent individual applicability, but also has the detection and monitoring of curative effect. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 Figure 1 is a structural diagram of an implant template in an embodiment of the present application.

[0019] In the figure: 1, gel layer; 2, flexible grid plate; 3, grid. DETAILED DESCRIPTION

[0020] The following will be described in detail in combination with the accompanying drawings. Figure 1 The present application will be further described in detail.

[0021] Embodiment:

[0022] Preparation of rubber material and flexible grid plate using the same:

[0023] Take 200g of rubber, 800g of mixed powder of bismuth, tungsten and barium, the mixed powder containing 160g of bismuth, 560g of tungsten and 80g of barium, mix the rubber and the mixed powder together, heat the mixed rubber material to melt, and then use a mold to make a flexible grid plate, the number of grids in the grid plate being 30, the size of each grid being 8x8 mm, the thickness of the grid plate being 3 mm and the height being 3 mm.

[0024] Preparation of fluorescent composite material and gel layer using the same:

[0025] Mix the prepolymer, photoinitiator and diluent to obtain a mixed resin liquid, irradiate with a UV lamp for 5s to make the resin in a gel state; take 600g of ZnS powder and add it to 400g of the resin in the gel state to obtain a corresponding fluorescent composite material. Apply the fluorescent composite material to the flexible grid plate, determine the position and angle of the implant needle according to the needs of the patient, insert the implant needle into the gel layer and through the lower grid space according to the determined position and angle, and perform UV irradiation to obtain a gel layer with a thickness of 8 mm. After curing, the implant needle is withdrawn, leaving a fixed direction aperture.

[0026] The flexible grid plate combined with the gel layer is the particle implant template prepared in the present application. When used, the prepared particle implant template is fixed around the patient's body, the needle hole reserved on the particle implant template is aligned with the operation position, and a radioactive particle implantation operation is performed, so that the radioactive particles are implanted into the body. After the radioactive particles are implanted into the body, the radiation is collimated by the grid plate and irradiated to the fluorescent layer, leaving a radiation luminescence pattern in the fluorescent layer, which can reduce the influence of gamma scattered rays on the image and more accurately reflect the pattern of radiation distribution. After the operation is completed, the success or failure of the operation can be intuitively judged by comparing the pattern generated by the radiation with the preset radiation pattern, and in the subsequent inspection process, the accuracy of the radioactive particle dose or the movement of the particles in the body can also be evaluated according to the shape of the template pattern.

[0027] The embodiments are only used for explaining the present application, and are not used for limiting the present application, and the person skilled in the art can make the modification of the embodiments without the creative contribution according to the need after reading the description, and as long as the modification is within the scope of the claims of the present application, it is protected by the patent law.

Claims

1. A template for particle implantation, characterized in that: The template includes a flexible mesh plate and a gel layer. The flexible mesh plate is made of a rubber material containing bismuth, tungsten, and tantalum powders, and the gel layer is made of a fluorescent composite material containing ZnS powder.

2. The template for particle implantation according to claim 1, characterized in that: The mesh plate has no fewer than 20 meshes, each mesh being 7×7 mm to 10×10 mm in size, the mesh plate being 3±0.1 mm thick and 3 mm to 5 mm in height, and the gel layer being no more than 10 mm thick.

3. The method for preparing a template for particle implantation according to claim 1, characterized in that: The method for preparing the rubber material for the flexible mesh plate is as follows: The mixture is made by mixing rubber with a mixed powder of bismuth, tungsten and barium, wherein the mass ratio of rubber to mixed powder is 1:4 and the mass ratio of bismuth, tungsten and barium in the mixed powder is 2:7:

1. The method for preparing the fluorescent composite material with the gel layer is as follows: A mixed resin liquid was obtained by mixing prepolymer, photoinitiator and diluent, and then irradiated with ultraviolet light for 5 seconds to make the resin gel. ZnS powder was added to the gelled resin, and the mass ratio of the gelled resin to ZnS powder was 4:

6.

4. A method for preparing a template for particle implantation, characterized in that: Flexible mesh plates and gel layers are prepared using the rubber material and fluorescent composite material prepared in claim 3, respectively. Then, the implantation needle is inserted into the gel layer at a determined position and angle and passes through the mesh gap below, and is cured by ultraviolet irradiation. After curing, the implantation needle is removed, leaving a hole with a fixed direction.

5. The application of the template for particle implantation according to claim 1 in measuring the dose rate of radioactive particles.

6. The application according to claim 5, characterized in that: The method for measuring the dose rate of radioactive particles is as follows: The prepared particle implantation template is fixed around the patient's body. The pre-reserved pinholes in the particle implantation template are aligned with the surgical site, and the radioactive particle implantation surgery is performed. After the radioactive particles are implanted into the body, the radiation is collimated by the grid plate and irradiated onto the fluorescent layer, leaving a radiation emission pattern on the fluorescent layer. This can reduce the influence of γ-scattered rays on the image and more accurately reflect the radiation distribution pattern. After the surgery is completed, the success of the surgery can be intuitively judged by comparing the pattern of radiation produced with the preset radiation pattern and the brightness contrast. In subsequent examinations, the shape of the template pattern can also be used to assess whether the dose of radioactive particles is accurate or whether the particles move in the body.

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