Lipidosome preparation high-pressure homogenizing device with efficient cooling and automatic cleaning functions

Abstract

The invention relates to the technical field of high-pressure homogenization, and provides a high-pressure homogenization device with efficient cooling and automatic cleaning for liposome preparation, the high-pressure homogenization device comprises a high-pressure homogenizer body and a feed hopper, the feed hopper is fixedly mounted on a feed pipe of the high-pressure homogenizer body, a fixing assembly is arranged on the outer side wall of the feed hopper, and the high-pressure homogenizer body is connected with the high-pressure homogenizer body. A fixing assembly is arranged on the high-pressure homogenizer body, a scraping assembly is arranged on the fixing assembly, a rotating assembly is arranged on the scraping assembly, a water pump is fixedly installed on one side of the high-pressure homogenizer body through a fixing frame, the output end of the water pump is fixedly connected with a conveying pipe, and water in an external water tank is pumped through the water pump. Then pumped water flows into an external water tank again after passing through a conveying pipe, a three-way joint, a cooling coil pipe, a spiral coil pipe, an L-shaped pipe and a connecting pipe, so that heat absorption and cooling treatment can be performed on the high-pressure homogenizer body, particles with different diameters are prevented from appearing after homogenization, and the high-pressure homogenizer is cooled, and meanwhile, under the action of a heat dissipation fan, a ventilation opening and a protective pore plate, the heat dissipation efficiency of the high-pressure homogenizer body is improved. And air cooling can be performed, so that the cooling efficiency is improved.

Description

Technical Field

[0001] This invention relates to the field of high-pressure homogenization technology, specifically to a high-pressure homogenization device for liposome preparation with efficient cooling and automatic cleaning. Background Technology

[0002] Liposomes are the core material of modern nanomedicine. As an advanced drug delivery system, they have shown great potential in improving therapeutic effects and reducing adverse reactions. With the advancement of technology, their application scope is constantly expanding. Pharmaceutical agents have strict requirements on the particle size of liposomes. The particle size must be within a certain unit and the distribution must be uniform. Therefore, the core of liposome preparation is the nano-sizing of liposomes and the precise control of liposome particle size. In the liposome preparation process, high-pressure homogenizers are used for processing, followed by filtration through low-pressure filters.

[0003] Chinese patent CN211586440U discloses a high-pressure homogenizing device for preparing liposomes, comprising a homogenizer body, a placement platform on the front of the homogenizer body, a high-pressure extruder on the top of the placement platform, and a homogenizer discharge pipe on the front of the homogenizer body; the high-pressure extruder has an internal cavity containing multiple filter tubes, a water inlet pipe on one side of the high-pressure extruder, and a water outlet pipe on the other side; each filter tube has a filter groove inside, and a filter discharge pipe passes through the bottom of the high-pressure extruder; a top cover is located above the connecting flange, and a filter feed pipe is located on the top of the top cover; the bottom of the high-pressure extruder has a bottom groove with internal teeth on its sides; an adjusting gear is located on the placement platform, and a transmission gear is located on one side of the adjusting gear, connecting the adjusting gear to the high-pressure extruder via the transmission gear. This invention significantly improves production efficiency through its overall structural design.

[0004] However, the above-mentioned solutions have the following problems when implementing related technologies: During high-pressure homogenization, the material is subjected to strong shearing, impact and cavitation, which generates a certain amount of heat. This may affect the performance of the material and the homogenization effect. At the same time, uneven distribution of material components may occur during liposome preparation, which reduces the homogenization effect during liposome preparation. In addition, material residue is easy to appear on the inner wall of the feed hopper during liposome homogenization. The inability to clean the material residue in time further affects the homogenization efficiency during liposome preparation, resulting in poor performance of liposomes. Therefore, a high-pressure homogenization device for liposome preparation with efficient cooling and automatic cleaning is proposed. Summary of the Invention

[0005] This invention proposes a high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning, which solves the problem in related technologies where the material is subjected to strong shearing, impact and cavitation during high-pressure homogenization, which generates a certain amount of heat, potentially affecting the material's performance and homogenization effect.

[0006] The technical solution of the present invention is as follows: a high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning, comprising a high-pressure homogenizer body and a feeding hopper, wherein the feeding hopper is fixedly installed on the feeding pipe of the high-pressure homogenizer body; A fixing component is provided on the outer side wall of the feed hopper, a scraping component is provided on the fixing component, and a rotating component is provided on the scraping component; A water pump is fixedly installed on one side of the high-pressure homogenizer body via a fixing frame. The output end of the water pump is fixedly connected to a delivery pipe, and a three-way connector is fixedly installed on the other end of the delivery pipe. A cooling coil, a temperature sensor, and a cooling fan are respectively installed inside the high-pressure homogenizer body, and one end of the three-way connector is fixedly connected to the inlet end of the cooling coil. A positioning shell is provided on one side of the high-pressure homogenizer body, and a spiral coil is fixedly installed inside the positioning shell. The discharge pipe of the high-pressure homogenizer body is located inside the spiral coil. An L-shaped pipe is fixedly installed at the other end of the three-way connector, and the other end of the L-shaped pipe is fixedly connected to the inlet end of the spiral coil. The water pump has a fixed extraction pipe installed at its input end, and the outlet end of the cooling coil, the outlet end of the spiral coil, and the other end of the extraction pipe are all connected to an external water tank through connecting pipes. The high-pressure homogenizer body has a vent on the rear side, and a protective perforated plate is provided on the inner side of the vent, and the protective perforated plate is fixedly installed on the high-pressure homogenizer body.

[0007] Preferably, the fixing component includes two fixing clips symmetrically arranged on the outside of the feed hopper, bolts are inserted into the round holes at the ends of the two fixing clips, nuts are threaded onto the outer side wall of the bolts, and the two fixing clips are fixedly installed on the outer side wall of the feed hopper by the bolts and the nuts; A locking mechanism is fixedly installed on the outer side wall of each of the two fixing clips. A mounting frame is provided above the feed hopper, and the mounting frame is installed on the fixing clip and the feed hopper through the locking mechanism.

[0008] The above technical solution facilitates the installation of the scraping component and the rotating component on the feed hopper, and also makes it easy to replace the damaged scraping component and the rotating component later.

[0009] Preferably, the locking mechanism includes a fixed housing that is fixedly installed on the outer side wall of the fixed card, and the end of the mounting bracket is inserted into a rectangular opening on the fixed housing; A T-shaped rod is provided through the fixed shell, and a spring is provided on the outer wall of the T-shaped rod, with the spring located inside the fixed shell. One end of the T-shaped rod is inserted into the round opening on the mounting bracket.

[0010] The above technical solution facilitates quick and easy assembly and disassembly of the mounting bracket, scraping component, and rotating component, thereby reducing disassembly and installation time and enabling the equipment to return to working condition more quickly, thus improving overall work efficiency.

[0011] Preferably, the scraping assembly includes an electric telescopic rod fixedly installed on the top wall of the high-pressure homogenizer body, a connecting frame fixedly installed at the bottom of the electric telescopic rod, and a fixing plate fixedly installed at the bottom of the connecting frame.

[0012] The above technical solution enables the rotating component to extend into the feed hopper for stirring, and at the same time, it can scrape and clean the upper side of the inner wall of the feed hopper. This can remove stubborn residues more quickly, shorten the cleaning cycle, improve production efficiency, and prevent residues from affecting the mixing effect of the new batch of materials, thus avoiding uneven mixing.

[0013] Preferably, the rotating assembly includes a motor fixedly mounted on the top of the fixed disk, a connecting rod fixedly mounted on the output end of the motor, and an arc-shaped frame fixedly mounted on the bottom of the connecting rod through one side wall of the fixed disk.

[0014] The above technical solution can scrape and clean the lower side of the inner wall of the feed hopper, thereby improving the cleaning effect. At the same time, it can also perform preliminary mixing of the material before it enters the homogenization chamber, ensuring that the material components are evenly distributed and improving the homogenization effect.

[0015] Preferably, the feed hopper is provided with a spiral conveying rod inside, the spiral conveying rod is provided with a plug-in mechanism, and the spiral conveying rod is plugged into the connecting rod through the plug-in mechanism; The connecting rod is provided with a locking mechanism, and the insertion mechanism is fixedly installed on the connecting rod through the locking mechanism.

[0016] The above technical solution can fix the screw conveyor rod on the connecting rod. When the connecting rod rotates, it can drive the screw conveyor rod synchronously, so that the screw conveyor rod can clear the connection between the feed pipe and the feed hopper, and avoid blockage when the feed hopper discharges material.

[0017] Preferably, the insertion mechanism includes a square groove formed at the bottom of the connecting rod, a square block is fixedly installed on the top of the spiral conveying rod, and the square block is inserted into the square groove. The square block is fixedly installed on the connecting rod by a locking mechanism.

[0018] The above technical solution enables the spiral conveyor rod to be quickly connected to the connecting rod, which then facilitates the locking mechanism to lock and fix it.

[0019] Preferably, the locking mechanism includes a plug-in housing sleeved on the connecting rod, wherein the plug-in housing, the connecting rod, and the square block are all provided with interconnected screw holes, and a fixing screw is threaded into the interconnected screw holes.

[0020] The above technical solution enables the screw conveyor to be stably fixed on the connecting rod, and also makes the screw conveyor easy to disassemble and assemble, thus facilitating the replacement of the screw conveyor later.

[0021] Preferably, the outer wall of the feed hopper is covered with an anti-slip pad, and the anti-slip pad is located between the feed hopper and the fixing component. A Velcro tack is fixedly installed on one side of the anti-slip pad, and a Velcro nut is fixedly installed on the other side of the anti-slip pad. The Velcro tack and the Velcro nut are adhered to each other.

[0022] The above technical solution can improve the friction between the fixed component and the feed hopper, thereby enabling the fixed component to be stably fixed in the feed hopper.

[0023] Preferably, the positioning shell includes a hollow cylinder sleeved on the body of the high-pressure homogenizer, and the spiral coil is fixedly installed inside the positioning shell. A hand-tightening screw is threaded onto the hollow cylinder, and the screw end of the hand-tightening screw extends into the interior of the hollow cylinder and is rotatably mounted with an arc-shaped plate.

[0024] The above technical solution enables the hollow cylinder and spiral coil to be quickly and stably fixed on the high-pressure homogenizer body for use.

[0025] The working principle and beneficial effects of this invention are as follows: 0. Water is drawn from the external water tank by a water pump. The drawn water then flows back into the external water tank through a delivery pipe, a tee joint, a cooling coil, a spiral coil, an L-shaped pipe, and a connecting pipe. This process allows the high-pressure homogenizer to absorb heat and cool down, preventing particles of different diameters from forming after homogenization. While cooling down, the cooling fan, vents, and protective perforated plate also provide air cooling, further improving cooling efficiency.

[0026] 1. By using the scraping component and the rotating component, the material before entering the homogenization chamber can be initially mixed to ensure uniform distribution of material components and improve the homogenization effect. In the later stage, the residual material attached to the inner wall of the feed hopper can be scraped and cleaned, shortening the cleaning cycle and improving production efficiency.

[0027] 2. The rotating assembly drives the locking and insertion mechanisms, thereby clearing the connection between the feed pipe and the feed hopper, preventing blockages during material discharge from the feed hopper. Attached Figure Description

[0028] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0029] Figure 1 This is a schematic diagram of the overall structure proposed in this invention; Figure 2 This is a top view schematic diagram of the structure proposed in this invention; Figure 3 This is a cross-sectional view of the feed hopper proposed in this invention; Figure 4 A schematic diagram of the structure of the anti-scalding pad is provided for this invention; Figure 5 A schematic diagram of the structure of the spiral conveyor rod is provided for this invention; Figure 6 A schematic diagram of the scraping component is provided for this invention; Figure 7 A schematic diagram of the locking mechanism proposed in this invention is provided; Figure 8 This invention proposes Figure 2 Enlarged structural diagram at point A in the diagram; Figure 9 This is a rear view structural diagram of the high-pressure homogenizer body proposed in this invention; Figure 10 This is a schematic diagram of the electrical connection structure proposed in this invention.

[0030] In the diagram: 1. High-pressure homogenizer body; 2. Feed hopper; 3. Screw conveyor; 4. Fixing components; 41. Fixing clips; 42. Bolts; 43. Locking mechanism; 44. Mounting bracket; 4301. Fixing housing; 4302. T-shaped rod; 4303. Spring; 5. Scraping assembly; 51. Electric telescopic pole; 52. Connecting frame; 53. Fixing plate; 6. Rotating assembly; 61. Motor; 62. Connecting rod; 63. Arc frame; 7. Water pump; 8. T-joint; 9. Cooling coil; 8. Positioning shell; 101. Hollow cylinder; 102. Hand screw; 103. Curved plate; 11. Spiral coil; 12. L-shaped tube; 13. Extraction tube; 14. Anti-slip pad; 15. Velcro strap; 16. Velcro nut; 17. Square groove; 18. Square block; 19. Plug-in housing; 20. Screw hole; 21. Fixing screw; 22. Protective hole plate. Detailed Implementation

[0031] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0032] Example 1 Please see Figures 1 to 10 A high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning includes a high-pressure homogenizer body 1 and a feed hopper 2, wherein the feed hopper 2 is fixedly installed on the feed pipe of the high-pressure homogenizer body 1. A fixing component 4 is provided on the outer wall of the feed hopper 2, a scraping component 5 is provided on the fixing component 4, and a rotating component 6 is provided on the scraping component 5; A water pump 7 is fixedly installed on one side of the high pressure homogenizer body 1 via a fixing frame. The output end of the water pump 7 is fixedly connected to a conveying pipe, and the other end of the conveying pipe is fixedly installed with a three-way connector 8. The interior of the high pressure homogenizer body 1 is respectively equipped with a cooling coil 9, a temperature sensor and a cooling fan, and one end of the three-way connector 8 is fixedly connected to the inlet end of the cooling coil 9. A positioning shell 10 is provided on one side of the high pressure homogenizer body 1. A spiral coil 11 is fixedly installed inside the positioning shell 10. The spiral coil 11 is made of non-metallic ion material. The discharge pipe of the high pressure homogenizer body 1 is located inside the spiral coil 11. An L-shaped pipe 12 is fixedly installed at the other end of the three-way connector 8. The other end of the L-shaped pipe 12 is fixedly connected to the inlet end of the spiral coil 11. The input end of the water pump 7 is fixedly equipped with an extraction pipe 13, and the outlet end of the cooling coil 9, the outlet end of the spiral coil 11, and the other end of the extraction pipe 13 are all connected to an external water tank through connecting pipes. A vent is provided on the rear side of the high-pressure homogenizer body 1. A protective perforated plate 22 is provided on the inner side of the vent, and the protective perforated plate 22 is fixedly installed on the high-pressure homogenizer body 1. A mechanical pressure relief valve and monitoring equipment can be installed on the protective perforated plate 22 to realize the whole process monitoring of the liposome preparation homogenization device.

[0033] This invention provides a high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning. During use, the scraping component 5 drives the rotating component 6 to descend, allowing the rotating component 6 to initially mix the material inside the feed hopper 2 before it enters the homogenizing chamber, ensuring uniform distribution of material components and improving homogenization. Then, the temperature is detected by a temperature sensor inside the high-pressure homogenizer body 1. When the detected temperature exceeds a preset value, the controller on the high-pressure homogenizer body 1 activates the water pump 7, causing the water pump 7 and the extraction pipe 13 to draw water from the external water tank. The drawn water then flows back into the external water tank through the delivery pipe, tee connector 8, cooling coil 9, spiral coil 11, L-shaped pipe 12, and connecting pipe. This process absorbs heat and cools the high-pressure homogenizer body 1, preventing particles of different diameters from appearing after homogenization. Simultaneously, cooling is achieved through a cooling fan, accelerating airflow within the high-pressure homogenizer body 1 and allowing heat to be expelled through the vents, thus improving cooling efficiency. This also effectively reduces equipment failure rate and extends equipment lifespan.

[0034] Furthermore, the fixing component 4 includes two fixing clips 41 symmetrically arranged on the outside of the feed hopper 2. Bolts 42 are inserted into the round holes at the ends of the two fixing clips 41. Nuts are threaded onto the outer side wall of the bolts 42, and the two fixing clips 41 are fixedly installed on the outer side wall of the feed hopper 2 by the bolts 42 and the nuts. Locking mechanisms 43 are fixedly installed on the outer walls of the two fixing clips 41. An mounting bracket 44 is provided above the feed hopper 2, and the mounting bracket 44 is installed on the fixing clips 41 and the feed hopper 2 through the locking mechanisms 43.

[0035] Specifically, the fixing clip 41 is fixed to the feed hopper 2 by bolts 42 and nuts, and then the mounting bracket 44 is fixed to the fixing clip 41 by locking mechanism 43. This makes it convenient to install the scraping component 5 and the rotating component 6 on the feed hopper 2 for use, and also makes it convenient to replace the damaged scraping component 5 and the rotating component 6 later.

[0036] Furthermore, the locking mechanism 43 includes a fixed housing 4301 fixedly mounted on the outer wall of the fixed card 41, and the end of the mounting bracket 44 is inserted into a rectangular opening on the fixed housing 4301; A T-shaped rod 4302 is provided through the fixed housing 4301. A spring 4303 is provided on the outer wall of the T-shaped rod 4302, and the spring 4303 is located inside the fixed housing 4301. One end of the T-shaped rod 4302 is inserted into the round opening on the mounting bracket 44.

[0037] Specifically, the spring 4303 pushes the T-shaped rod 4302 with its own elastic force, so that the T-shaped rod 4302 moves stably under the action of the fixed shell 4301 and moves into the round hole on the mounting bracket 44, so that the mounting bracket 44, the scraping component 5 and the rotating component 6 can be quickly disassembled and assembled.

[0038] Furthermore, the scraping assembly 5 includes an electric telescopic rod 51 fixedly installed on the inner top wall of the high-pressure homogenizer body 1, a connecting frame 52 fixedly installed at the bottom of the electric telescopic rod 51, and a fixing plate 53 fixedly installed at the bottom of the connecting frame 52.

[0039] Specifically, the electric telescopic rod 51 drives the connecting frame 52 and the fixed plate 53 to descend, thereby allowing the rotating component 6 to extend into the feed hopper 2 for stirring. At the same time, the fixed plate 53 can also scrape and clean the upper side of the inner wall of the feed hopper 2.

[0040] Furthermore, the rotating assembly 6 includes a motor 61 fixedly mounted on the top of the fixed disk 53, a connecting rod 62 fixedly mounted on the output end of the motor 61, and an arc-shaped frame 63 fixedly mounted on the bottom of the connecting rod 62 through one side wall of the fixed disk 53.

[0041] Specifically, the motor 61 drives the connecting rod 62 to rotate, thereby enabling the arc frame 63 to scrape and clean the lower side of the inner wall of the feed hopper 2. This not only removes stubborn residues more quickly, shortens the cleaning cycle, and improves production efficiency, but also prevents residues from affecting the mixing effect of the new batch of materials and causing uneven mixing. At the same time, the motor 61, connecting rod 62 and arc frame 63 can also perform preliminary mixing of the materials before they enter the homogenization chamber, ensuring that the material components are evenly distributed and improving the homogenization effect.

[0042] Furthermore, the positioning shell 10 includes a hollow cylinder 101 sleeved on the high-pressure homogenizer body 1, and a spiral coil 11 is fixedly installed inside the positioning shell 10. A hand screw 102 is threadedly connected to the hollow cylinder 101, and an arc plate 103 is rotatably installed inside the hollow cylinder 101.

[0043] Specifically, by manually turning the hand-tightening screw 102 connected to the thread on the hollow cylinder 101, the arc plate 103 is lowered and squeezed against the high-pressure homogenizer body 1, thereby enabling the hollow cylinder 101 and the spiral coil 11 to be quickly and stably fixed on the high-pressure homogenizer body 1 for use.

[0044] Example 2 Based on Embodiment 1, in this embodiment: a spiral conveying rod 3 is provided inside the feed hopper 2, and a plug-in mechanism is provided on the spiral conveying rod 3, and the spiral conveying rod 3 is plugged into the connecting rod 62 through the plug-in mechanism; A locking mechanism is provided on the connecting rod 62, and the insertion mechanism is fixedly installed on the connecting rod 62 through the locking mechanism.

[0045] The technical solution provided in this embodiment is as follows: the screw conveyor 3 is fixed on the connecting rod 62 by the plug-in mechanism, and then locked by the locking mechanism. When the scraping component 5 drives the rotating component 6 to descend, the screw conveyor 3 is inserted into the feed pipe. When the rotating component 6 rotates, it drives the screw conveyor 3 synchronously, so that the screw conveyor 3 can clear the connection between the feed pipe and the feed hopper, and avoid blockage when the feed hopper discharges material.

[0046] Furthermore, the insertion mechanism includes a square groove 17 formed at the bottom of the connecting rod 62, a square block 18 fixedly installed on the top of the spiral conveying rod 3, and the square block 18 is inserted into the square groove 17. The square block 18 is fixedly installed on the connecting rod 62 by a locking mechanism.

[0047] Specifically, during installation, the square block 18 is manually inserted into the square groove 17, so that the spiral conveying rod 3 can be quickly connected to the connecting rod 62, and then the locking mechanism can lock and fix it.

[0048] Furthermore, the locking mechanism includes a plug-in housing 19 sleeved on the connecting rod 62. Both the plug-in housing 19, the connecting rod 62, and the square block 18 have interconnected screw holes 20, and the interconnected screw holes 20 are internally threaded with fixing screws 21.

[0049] Specifically, by manually screwing the fixing screws 21 into the connected screw holes 20, the square block 18 and the spiral conveying rod 3 can be fixed, so that the spiral conveying rod 3 can be stably fixed on the connecting rod 62. At the same time, the spiral conveying rod 3 is easy to disassemble and assemble, and thus easy to replace the spiral conveying rod 3 later.

[0050] Example 3 Based on Embodiment 1, in this embodiment: the outer wall of the feed hopper 2 is covered with an anti-slip pad 14, and the anti-slip pad 14 is located between the feed hopper 2 and the fixing component 4. A Velcro 15 is fixedly installed on one side of the anti-slip pad 14, and a Velcro 16 is fixedly installed on the other side of the anti-slip pad 14. The Velcro 15 and the Velcro 16 are adhered to each other.

[0051] The technical solution provided in this embodiment is as follows: by using the Velcro 15 and Velcro 16, the anti-slip pad 14 can be fixed on the outside of the feed hopper 2. Then, under the action of the anti-slip pad 14, the friction between the fixing component 4 and the feed hopper 2 can be increased, so that the fixing component 4 can be stably fixed on the feed hopper 2.

[0052] Additionally, it should be noted that when the anti-slip mat 14 increases the friction between the fixing component 4 and the feed hopper 2, the fixing effect between the anti-slip mat 14 and the feed hopper 2 is improved under the fastening of the fixing component 4.

[0053] The working principle and usage process of this invention are as follows: Material is manually added to the feed hopper 2. Then, the electric telescopic rod 51 drives the connecting frame 52 and the fixed plate 53 to descend. Simultaneously, the motor 61 drives the connecting rod 62 to rotate, allowing the arc-shaped frame 63 to initially mix the material inside the feed hopper 2 before it enters the homogenization chamber. This ensures uniform distribution of material components and improves the homogenization effect. It also allows the screw conveyor 3 to clear the connection between the feed pipe and the feed hopper, preventing blockages during material discharge. Then, the temperature is detected by a temperature sensor inside the high-pressure homogenizer body 1. When the detected temperature exceeds a preset value, the high-pressure homogenizer... The controller on the high-pressure homogenizer body 1 starts the water pump 7 and the cooling fan, so that the water pump 7 and the extraction pipe 13 draw water from the external water tank. The drawn water then flows back into the external water tank through the delivery pipe, the tee joint 8, the cooling coil 9, the spiral coil 11, the L-shaped pipe 12 and the connecting pipe. This allows the high-pressure homogenizer body 1 to absorb heat and cool down, avoiding the appearance of particles of different diameters after homogenization. At the same time, the cooling fan can provide air cooling, which can accelerate the air flow inside the high-pressure homogenizer body 1, allowing heat to be discharged from the vent in time, thereby improving the cooling efficiency. It can also effectively reduce the equipment failure rate and extend the service life of the equipment.

[0054] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning, comprising a high-pressure homogenizer body (1) and a feed hopper (2), characterized in that, The feed hopper (2) is fixedly installed on the feed pipe of the high pressure homogenizer body (1); A fixing component (4) is provided on the outer side wall of the feed hopper (2), a scraping component (5) is provided on the fixing component (4), and a rotating component (6) is provided on the scraping component (5). A water pump (7) is fixedly installed on one side of the high-pressure homogenizer body (1) by a fixing frame. The output end of the water pump (7) is fixedly connected to a conveying pipe. A three-way connector (8) is fixedly installed on the other end of the conveying pipe. A cooling coil (9), a temperature sensor and a heat dissipation fan are respectively installed inside the high-pressure homogenizer body (1). One end of the three-way connector (8) is fixedly connected to the inlet end of the cooling coil (9). A positioning shell (10) is provided on one side of the high pressure homogenizer body (1). A spiral coil (11) is fixedly installed inside the positioning shell (10). The discharge pipe of the high pressure homogenizer body (1) is located inside the spiral coil (11). An L-shaped pipe (12) is fixedly installed at the other end of the three-way connector (8). The other end of the L-shaped pipe (12) is fixedly connected to the inlet end of the spiral coil (11). The water pump (7) has an extraction pipe (13) fixedly installed at its input end, and the outlet end of the cooling coil (9), the outlet end of the spiral coil (11) and the other end of the extraction pipe (13) are all connected to an external water tank through connecting pipes. The high-pressure homogenizer body (1) has an air vent on its rear side, and a protective hole plate (22) is provided on the inner side of the air vent. The protective hole plate (22) is fixedly installed on the high-pressure homogenizer body (1).

2. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 1, characterized in that: The fixing component (4) includes two fixing clips (41) symmetrically arranged on the outside of the feed hopper (2). Bolts (42) are inserted into the round holes at the ends of the two fixing clips (41). Nuts are threaded onto the outer side wall of the bolts (42). The two fixing clips (41) are fixedly installed on the outer side wall of the feed hopper (2) by the bolts (42) and the nuts. Locking mechanisms (43) are fixedly installed on the outer side walls of the two fixing cards (41), and a mounting bracket (44) is provided above the feed hopper (2), and the mounting bracket (44) is installed on the fixing card (41) and the feed hopper (2) through the locking mechanism (43).

3. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 2, characterized in that: The locking mechanism (43) includes a fixed housing (4301) fixedly installed on the outer wall of the fixed card (41), and the end of the mounting bracket (44) is inserted into a rectangular opening on the fixed housing (4301); A T-shaped rod (4302) is provided through the fixed shell (4301). A spring (4303) is provided on the outer wall of the T-shaped rod (4302), and the spring (4303) is located on the inner side of the fixed shell (4301). One end of the T-shaped rod (4302) is inserted into the round opening on the mounting bracket (44).

4. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 3, characterized in that: The scraping assembly (5) includes an electric telescopic rod (51) fixedly installed on the inner top wall of the mounting frame (44), a connecting frame (52) fixedly installed at the bottom of the electric telescopic rod (51), and a fixing plate (53) fixedly installed at the bottom of the connecting frame (52).

5. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 4, characterized in that: The rotating assembly (6) includes a motor (61) fixedly mounted on the top of the fixed disk (53), a connecting rod (62) fixedly mounted on the output end of the motor (61), and an arc frame (63) fixedly mounted on the bottom of the connecting rod (62) through one side wall of the fixed disk (53).

6. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 5, characterized in that: The feed hopper (2) is provided with a spiral conveying rod (3), and the spiral conveying rod (3) is provided with a plug-in mechanism, and the spiral conveying rod (3) is plugged into the connecting rod (62) through the plug-in mechanism; The connecting rod (62) is provided with a locking mechanism, and the insertion mechanism is fixedly installed on the connecting rod (62) through the locking mechanism.

7. The high-pressure homogenizing apparatus for liposome preparation with efficient cooling and automatic cleaning as described in claim 6, characterized in that: The insertion mechanism includes a square groove (17) formed at the bottom of the connecting rod (62), a square block (18) is fixedly installed on the top of the spiral conveying rod (3), and the square block (18) is inserted into the square groove (17). The square block (18) is fixedly installed on the connecting rod (62) by a locking mechanism.

8. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 7, characterized in that: The locking mechanism includes a plug-in housing (19) sleeved on the connecting rod (62). The plug-in housing (19), the connecting rod (62) and the square block (18) are all provided with interconnected screw holes (20). The interconnected screw holes (20) are internally threaded with fixing screws (21).

9. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 1, characterized in that: The outer wall of the feed hopper (2) is covered with an anti-slip pad (14), and the anti-slip pad (14) is located between the feed hopper (2) and the fixing component (4). A Velcro strip (15) is fixedly installed on one side of the anti-slip pad (14), and a Velcro strip (16) is fixedly installed on the other side of the anti-slip pad (14). The Velcro strip (15) and the Velcro strip (16) are glued together.

10. The high-pressure homogenizing device for liposome preparation with efficient cooling and automatic cleaning as described in claim 1, characterized in that: The positioning shell (10) includes a hollow cylinder (101) sleeved on the high pressure homogenizer body (1), and the spiral coil (11) is fixedly installed inside the positioning shell (10). A hand screw (102) is threaded onto the hollow cylinder (101), and the screw end of the hand screw (102) extends into the interior of the hollow cylinder (101) and is rotatably mounted with an arc plate (103).

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