Use of tab2 in the diagnosis and treatment of parkinson's disease

By using TAB2 inhibitors such as siRNA and shRNA to reduce TAB2 levels, the problem of Parkinson's disease progression was solved, enabling effective diagnosis and treatment of PD and improving motor function in PD mice.

CN121313838BActive Publication Date: 2026-06-05BEIJING NEUROSURGICAL INST
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING NEUROSURGICAL INST
Filing Date
2025-10-22
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

There is a lack of effective methods to stop the progression of Parkinson's disease in the current technology. Existing treatments have serious adverse reactions after long-term use, and there are no effective therapies to slow the course of the disease.

Method used

Inhibitors of TAB2, such as siRNA, shRNA, ribozymes, and antisense oligonucleotides, are used to prepare drugs for treating Parkinson's disease, which block disease progression by lowering TAB2 levels. Reagents for detecting TAB2 levels are also provided for diagnosis.

Benefits of technology

In animal and cell models of PD, inhibition of TAB2 reduced apoptosis-related proteins in neurons and improved motor function in PD mice, providing an effective direction for diagnosis and treatment.

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Abstract

The application discloses application of TAB2 in diagnosis and treatment of Parkinson's disease. Through analysis of a cerebral single cell data set of PD patients, it is shown that microglia cells are significantly increased, and a microglia cell differential gene TAB2 is screened in combination with bulk transcriptome data; after TAB2 is knocked down in a PD animal and cell model, apoptosis pathway related proteins in neurons are significantly reduced compared with a model group, and the motor function of a PD mouse is improved. It is shown that TAB2 has a good effect on blocking the progress of PD, and a new direction is provided for effective diagnosis and timely treatment of Parkinson's disease.
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Citation Information

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