Enzyme-containing oral care ointment composition, toothpaste and application
By combining enzyme compositions in specific ratios with other additives, the stability of enzymes in toothpaste has been solved, achieving long-term maintenance of enzyme activity and effective removal of dental plaque. This also addresses the issue of enzyme activity being easily affected, resulting in rapid and effective plaque removal.
Patent Information
- Application Number
- CN202511701901.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-19
- Publication Date
- 2026-01-16
AI Technical Summary
Enzymes in toothpaste are easily affected by the external environment, leading to reduced activity or inactivation, making it difficult to maintain their effectiveness against dental plaque in the long term.
By combining enzyme compositions, cationic bactericides, humectants, foaming agents, and abrasives in specific ratios, the stability of the enzymes in toothpaste is ensured. The synergistic action of dextranase and α-glucosidase is used to decompose the dental plaque matrix, and the synergistic action of cationic bactericides is combined to quickly remove dental plaque.
It maintains enzyme activity during long-term storage, effectively decomposes and kills dental plaque, quickly removes dental plaque, and inhibits its growth.
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Abstract
Description
Technical Field
[0001] This application relates to the field of oral care product technology, specifically to enzyme-containing oral care paste compositions, toothpaste, and applications. Background Technology
[0002] Dental plaque is a soft, unmineralized colony of bacteria encased in a matrix and adhering to each other, or to the surfaces of teeth, between teeth, or on the surfaces of restorations. It cannot be easily rinsed away with water or mouthwash. Dental plaque is the primary environment for the survival and metabolism of pathogenic bacteria in the oral cavity, causing two of the most common oral diseases: dental caries and periodontal disease. Therefore, how to clean and inhibit dental plaque is of great importance to oral health and hygiene.
[0003] Adding enzymes to oral care products is a technique to combat dental plaque. This technique utilizes the highly efficient catalytic ability of enzymes to break down the insoluble plaque polysaccharide matrix and sugars in food debris, reducing the adhesiveness of polysaccharides and decreasing the accumulation of sugars. This weakens the adhesion of dental plaque to teeth, making it easier to remove from the mouth.
[0004] However, enzymes are relatively sensitive substances, and their activity is easily affected by the external environment. Toothpaste, on the other hand, is a complex mixture, which can easily affect the efficacy and stability of enzymes, especially during long-term storage, when enzyme activity can decrease or even become inactive. Summary of the Invention
[0005] Based on this, this application provides an enzyme-containing oral care paste composition, as well as toothpaste and application. This enzyme-containing oral care paste composition has the effect of inhibiting dental plaque and can maintain enzyme activity for a long time.
[0006] A first aspect of this application provides an enzyme-containing oral care ointment composition, comprising, by weight percentage, the following components:
[0007] Enzyme composition 0.4%~2%,
[0008] Cationic bactericide 0.03%~0.3%,
[0009] Moisturizer 20%~80%,
[0010] Foaming agent 1.5%~5%, and,
[0011] Friction agent 15%~75%;
[0012] The enzyme composition includes dextranase and α-glucosidase;
[0013] The moisturizer includes polyethylene glycol, the average molecular weight of which is greater than or equal to 300 g / mol, and the mass percentage of which is greater than or equal to 5% in the enzyme-containing oral care ointment composition;
[0014] The foaming agent includes one or more of nonionic surfactants and amphoteric surfactants, optionally including anionic surfactants, wherein the anionic surfactant accounts for less than or equal to 1% by mass in the enzyme-containing oral care ointment composition;
[0015] The friction agent includes silicon dioxide.
[0016] In some embodiments, the dextranase in the enzyme-containing oral care ointment composition is 0.3% to 1% by mass, and the α-glucosidase is 0.1% to 1% by mass.
[0017] Optionally, the dextranase has an enzyme activity of 30,000 U / g or higher;
[0018] Optionally, the α-glucosidase has an enzyme activity of 2500 U / g or higher;
[0019] Optionally, in the enzyme-containing oral care ointment composition, the dextranase has a mass percentage of 0.4% to 0.8%.
[0020] Optionally, in the enzyme-containing oral care ointment composition, the α-glucosidase has a mass percentage of 0.2% to 0.6%.
[0021] In some embodiments, the cationic bactericide includes one or more of cetylpyridinium chloride, domiphen, and chlorhexidine.
[0022] In some embodiments, the cationic bactericide in the enzyme-containing oral care ointment composition is 0.1% to 0.16% by mass.
[0023] In some embodiments, the nonionic surfactant includes one or more of lauryl glucoside, poloxamer, and polyoxyethylene hydrogenated castor oil.
[0024] In some embodiments, the zwitterionic surfactant includes one or more of cocamidopropyl betaine, sodium lauroyl sarcosinate, and sodium methyl lauroyl taurate.
[0025] In some embodiments, the anionic surfactant includes sodium lauryl sulfate.
[0026] A second aspect of this application provides a toothpaste comprising the enzyme-containing oral care paste composition described in the first aspect.
[0027] In some embodiments, the toothpaste further includes functional additives, which include one or more of flavoring agents, thickeners, preservatives, taste modifiers, and appearance modifiers.
[0028] A third aspect of this application provides the use of the enzyme-containing oral care paste composition of the first aspect or the toothpaste of the second aspect in the preparation of an formulation having the effect of removing dental plaque.
[0029] The above-mentioned enzyme-containing oral care paste composition, through the specific compatibility of the cationic bactericide, humectant, foaming agent, abrasive and other components in the system with the enzyme composition, can effectively solve the stability problem of enzymes in oral care pastes such as toothpaste, ensure the controllability of enzyme activity within the shelf life, maintain enzyme activity during long-term storage, and through the synergistic effect of two biological enzymes and cationic bactericides, can effectively decompose the matrix of dental plaque, kill harmful bacteria in dental plaque, thereby breaking down dental plaque, quickly and effectively removing dental plaque, and inhibiting the growth of dental plaque. Detailed Implementation
[0030] The enzyme-containing oral care paste composition, toothpaste, and application of this application are further described in detail below with reference to specific embodiments. This application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and complete understanding of the disclosure of this application.
[0031] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.
[0032] As used herein, the terms “and / or,” “or / and,” and “and / or” may include any one of two or more of the related listed items, as well as any and all combinations of the related listed items, including any two related listed items, any more related listed items, or a combination of all the related listed items.
[0033] In this article, "one or more" refers to any one, two or more of the listed items.
[0034] In this application, terms such as "first aspect," "second aspect," and "third aspect" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or quantity, nor should they be construed as implicitly indicating the importance or quantity of the indicated technical features. Moreover, terms such as "first," "second," and "third" serve only as a non-exhaustive enumeration and should be understood not to constitute a closed limitation on quantity.
[0035] In this application, the technical features described in an open-ended manner include both closed technical solutions consisting of the listed features and open technical solutions that include the listed features.
[0036] In this application, numerical ranges are referred to as continuous unless otherwise specified, and include the minimum and maximum values of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are incorporated.
[0037] Unless otherwise specified, the percentage content mentioned in this application refers to mass percentage for solid-liquid mixtures and solid-phase-solid mixtures, and volume percentage for liquid-phase-liquid mixtures.
[0038] Unless otherwise specified, all percentage concentrations mentioned in this application refer to the final concentration. The final concentration refers to the proportion of the added component in the system after the addition of that component.
[0039] Unless otherwise specified, the temperature parameters in this application may be either constant temperature processing or processing within a certain temperature range. The constant temperature processing allows for temperature fluctuations within the precision range controlled by the instrument.
[0040] In this application, room temperature generally refers to 4℃~30℃, and more preferably 20±5℃.
[0041] Some embodiments of this application provide an enzyme-containing oral care ointment composition, comprising, by weight percentage, the following components:
[0042] Enzyme composition 0.4%~2%,
[0043] Cationic bactericide 0.03%~0.3%,
[0044] Moisturizer 20%~80%,
[0045] Foaming agent 1.5%~5%, and,
[0046] Friction agent 15%~75%;
[0047] The enzyme composition includes dextranase and α-glucosidase;
[0048] The moisturizer includes polyethylene glycol, the average molecular weight of which is greater than or equal to 300 g / mol, and the mass percentage of which is greater than or equal to 5% in the enzyme-containing oral care ointment composition;
[0049] The foaming agent includes one or more of nonionic surfactants and amphoteric surfactants, optionally including anionic surfactants, wherein the anionic surfactant accounts for less than or equal to 1% by mass in the enzyme-containing oral care ointment composition;
[0050] The friction agent includes silicon dioxide.
[0051] Furthermore, regarding the enzyme composition:
[0052] In some embodiments, the enzyme composition retains more than 90% of the enzyme activity of both dextranase and α-glucosidase after being stored at room temperature for 18 months.
[0053] Specifically, the mass percentage of the enzyme composition includes, but is not limited to: 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, or any two of the foregoing.
[0054] In some embodiments, the dextranase in the enzyme-containing oral care ointment composition is 0.3% to 1% by mass, and the α-glucosidase is 0.1% to 1% by mass. Specifically, the mass percentage of the dextranase includes, but is not limited to, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, or any range between the foregoing; the mass percentage of the α-glucosidase includes, but is not limited to, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, or any range between the foregoing. Further, the dextranase in the enzyme-containing oral care ointment composition is 0.4% to 0.8% by mass; the α-glucosidase in the enzyme-containing oral care ointment composition is 0.2% to 0.6% by mass.
[0055] Dextranase hydrolyzes the α-1,6-glycosidic bonds of carbohydrates, while α-glucosidase breaks the α-1,4-glycosidic bonds of carbohydrates. During the experiments of this invention, it was unexpectedly discovered that by rationally combining dextranase and α-glucosidase in a certain ratio, a synergistic effect can be produced, significantly enhancing the hydrolytic ability of carbohydrates and thus reducing the adhesion of dental plaque to teeth.
[0056] In some embodiments, the dextranase has an enzyme activity of 30,000 U / g or higher.
[0057] In some embodiments, the α-glucosidase has an enzyme activity of 2500 U / g or higher.
[0058] Furthermore, regarding the cationic bactericide:
[0059] Specifically, the mass percentage of the cationic bactericide includes, but is not limited to, 0.03%, 0.05%, 0.07%, 0.1%, 0.13%, 0.16%, 0.18%, 0.2%, 0.23%, 0.26%, 0.28%, 0.3%, or any range between the foregoing. Further, in the enzyme-containing oral care ointment composition, the mass percentage of the cationic bactericide is 0.1% to 0.16%.
[0060] In some embodiments, the cationic bactericide includes one or more of cetylpyridinium chloride, domiphen, and chlorhexidine. Cetylpyridinium chloride, domiphen, and chlorhexidine are all cationic bactericides, with higher bactericidal efficacy than plant extract-based bactericides. They can rapidly kill bacteria in dental plaque, inhibit plaque growth, and their positive charge can neutralize the anionic groups in toothpaste ingredients, forming an electrostatic balance and protecting enzyme activity. Further, the cationic bactericide includes cetylpyridinium chloride.
[0061] Furthermore, regarding the humectant:
[0062] Specifically, the mass percentage of the humectant includes, but is not limited to: 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, or any range between the two mentioned above.
[0063] Understandably, the humectant may be composed solely of polyethylene glycol with an average molecular weight greater than or equal to 300 g / mol, i.e., the mass percentage of polyethylene glycol in the humectant is 100%, or it may be a combination of polyethylene glycol with an average molecular weight greater than or equal to 300 g / mol and other alcohol humectants, wherein the other alcohol humectants include one or more of sorbitol, glycerin and propylene glycol.
[0064] In some embodiments, the polyethylene glycol is present in the enzyme-containing oral care ointment composition at a mass percentage of 5% to 50%. Specifically, the mass percentage of polyethylene glycol in the enzyme-containing oral care ointment composition includes, but is not limited to: 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, or any range between the foregoing.
[0065] Furthermore, regarding the foaming agent:
[0066] Specifically, the mass percentage of the foaming agent includes, but is not limited to: 1.5%, 2%, 2.5%, 2.8%, 3%, 3.5%, 4%, 4.5%, 5%, or any two of the foregoing.
[0067] Understandably, the foaming agent may be one or more of the nonionic surfactant and the amphoteric surfactant, and may also include anionic surfactants. In the case of including anionic surfactants, the mass percentage of the anionic surfactant in the enzyme-containing oral care ointment composition is less than or equal to 1%.
[0068] In some embodiments, the anionic surfactant is present in the enzyme-containing oral care ointment composition at a mass percentage of 0% to 1%. Specifically, the mass percentage of the anionic surfactant in the enzyme-containing oral care ointment composition includes, but is not limited to: 0%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, or any range between the foregoing.
[0069] In some embodiments, the nonionic surfactant includes one or more of lauryl glucoside, poloxamer, and polyoxyethylene hydrogenated castor oil.
[0070] In some embodiments, the zwitterionic surfactant includes one or more of cocamidopropyl betaine, sodium lauroyl sarcosinate, and sodium methyl lauroyl taurate.
[0071] In some embodiments, the anionic surfactant includes sodium lauryl sulfate.
[0072] Furthermore, regarding the friction agent:
[0073] Different abrasives have a significant impact on the enzyme composition of this application. Studies have found that calcium carbonate and calcium hydrogen phosphate easily lead to enzyme inactivation. Through repeated experiments, silica has been confirmed as the abrasive used in this application.
[0074] Specifically, the mass percentage of the friction agent includes, but is not limited to: 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, or any range between the two mentioned above.
[0075] In some embodiments, the abrasive is not calcium carbonate or calcium hydrogen phosphate.
[0076] Other embodiments of this application provide toothpaste, including the enzyme-containing oral care paste composition described above.
[0077] Without limitation, the toothpaste contains water and, by mass percentage, comprises the following components:
[0078] The enzyme composition is 0.4%~2%.
[0079] The cationic bactericide is 0.03%~0.3%.
[0080] The moisturizer is 20%~50%
[0081] The foaming agent is 1.5%~5%.
[0082] The friction agent is 15%~50%, and,
[0083] The water content is 25% to 35%.
[0084] Specifically, the mass percentage of the enzyme composition includes, but is not limited to: 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, or any two of the foregoing.
[0085] Specifically, the mass percentage of the cationic bactericide includes, but is not limited to: 0.03%, 0.05%, 0.07%, 0.1%, 0.13%, 0.16%, 0.18%, 0.2%, 0.23%, 0.26%, 0.28%, 0.3%, or any range between the foregoing. Further, the mass percentage of the cationic bactericide is 0.1% to 0.16%.
[0086] Specifically, the mass percentage of the moisturizer includes, but is not limited to: 20%, 25%, 30%, 35%, 40%, 45%, 50%, or any two of the foregoing.
[0087] Specifically, the mass percentage of the foaming agent includes, but is not limited to: 1.5%, 2%, 2.5%, 2.8%, 3%, 3.5%, 4%, 4.5%, 5%, or any two of the foregoing.
[0088] Specifically, the mass percentage of the friction agent includes, but is not limited to: 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, or any two of the foregoing.
[0089] Without limitation, the toothpaste also includes functional additives, which include one or more of flavoring agents, thickeners, preservatives, taste modifiers, and appearance modifiers. These can be added as needed.
[0090] Other embodiments of this application provide the use of the enzyme-containing oral care paste composition as described above or the toothpaste as described above in the preparation of formulations with plaque-removing effects.
[0091] For experimental parameters not specified in the following specific embodiments, please refer to the guidelines given in this application document first, or refer to experimental manuals or other experimental methods known in the art, or refer to the experimental conditions recommended by the manufacturer.
[0092] The raw materials and reagents involved in the following specific embodiments can be obtained commercially or prepared by those skilled in the art using known methods.
[0093] The toothpaste formulations provided in the examples and comparative examples are shown in Table 1 below:
[0094] Table 1
[0095]
[0096] The toothpaste preparation methods provided in the above embodiments and comparative examples are as follows:
[0097] 1) Mix the cationic bactericide composition, the moisturizer composition, and water, stir until completely dissolved and homogeneous, and then add to the ointment preparation pot;
[0098] 2) After mixing the abrasive and xanthan gum evenly, add them to the paste-making pot and stir under negative pressure for about 30 minutes;
[0099] 3) Add the foaming agent composition to the paste obtained in step 2) and stir under negative pressure for about 10 minutes;
[0100] 4) Add the enzyme composition and fragrance to the paste obtained in step 3), and stir under negative pressure for about 10 minutes to obtain the toothpaste.
[0101] Comparative Example 11 provides a commercially available toothpaste with the following formula: sorbitol, glycerin, silica, sodium lauryl sulfate, cocamidopropyl betaine, pentasodium tripolyphosphate, sodium phytate, PVM / MA copolymer, polyvinylpyrrolidone, papain, and a combination of dextranase. Testing revealed that the weight percentage of sodium lauryl sulfate in this commercially available toothpaste is approximately 2%.
[0102] Performance comparison test
[0103] 1. Test of ability to inhibit and break down dental plaque
[0104] 1.1 Test Samples:
[0105] Examples 1-3, Comparative Examples 1-6.
[0106] 1.2 Test methods and evaluation criteria:
[0107] (1) Test method for inhibiting biofilm formation: Add the test sample solution diluted with toothpaste and pure water at a weight ratio of 1:2 to the 12-well plate, then add the culture medium of Streptococcus mutans biofilm, mix well and incubate for 24 hours. After that, completely remove the suspension of the sample solution and the mixture of bacterial solution in the well. Place the well plate in a 50℃ oven to dry and fix the biofilm for more than 4 hours. Then add staining agent to the biofilm wells and stain. Then compare the biofilm with the control group that was cultured simultaneously and did not have toothpaste treatment to obtain the corresponding biofilm reduction rate (BRR). The specific evaluation criteria are shown in Table 2.
[0108] (2) Biofilm Disintegration Test Method: Add Streptococcus mutans biofilm culture medium to a 12-well plate and incubate for 24 hours. Add the test sample solution diluted with toothpaste and pure water at a weight ratio of 1:2 to the biofilm model and let it act for 3 minutes. Completely remove the suspension of the bacterial solution mixture in the well. Place the well plate in a 50℃ oven to dry and fix the biofilm for more than 4 hours. Then add staining agent to the biofilm wells and stain. Then compare the biofilm with the control group biofilm that was cultured simultaneously and did not have toothpaste treatment. The corresponding biofilm reduction rate (BRR) is obtained. The specific evaluation criteria are shown in Table 2.
[0109] Table 2 Evaluation Criteria for Inhibiting Biofilm Disintegration
[0110]
[0111] 1.3 Test Results:
[0112] The toothpaste samples from Examples 1-3 and Comparative Examples 1-5 were tested for their ability to inhibit plaque formation / disintegrate, and the results are shown in Table 3.
[0113] Table 3 Summary of Test Results for Inhibition of Biofilm Formation / Disintegration
[0114]
[0115] Based on the above test results, it can be seen that each embodiment has a strong ability to break down and inhibit dental plaque; the absence of dextranase or α-glucosidase will significantly reduce this ability; the weight percentage of the enzyme composition is less than 0.3%, the absence of the enzyme composition or the absence of a cationic bactericide will greatly reduce this ability; the absence of both enzymes and the cationic bactericide will result in no ability to break down and inhibit dental plaque.
[0116] 2. Enzyme activity retention test
[0117] 2.1 Test Samples:
[0118] Examples 1-3 and Comparative Examples 7-11 were kept at room temperature for 18 months.
[0119] 2.2 Sample Preparation:
[0120] Dissolve the toothpaste sample in an appropriate amount of pure water to form a toothpaste slurry with a certain dilution factor, centrifuge, and take the supernatant for later use.
[0121] 2.3 Preparation of reference standards:
[0122] Dissolve and dilute the enzyme with an appropriate amount of pure water to prepare an aqueous solution with the same enzyme concentration as the supernatant of the toothpaste sample to be tested, and set aside for later use.
[0123] 2.4 Enzyme activity test:
[0124] (1) Dextranase: The method was performed according to Appendix A of the group standard for oral care products, "Dextranase for Toothpaste in Oral Hygiene Products (T / COCIA 35-2024)". The enzyme activity (U / L) of the toothpaste sample was tested. A1 ), enzyme activity of the reference standard (U A2 ).
[0125] (2) α-Glucosidase: The method was performed according to Appendix B, Section B.5 of the national standard GB 1886.174-2024, "National Food Safety Standard - Food Additives and Enzyme Preparations for Food Industry". The enzyme activity (U / L) of the toothpaste sample was tested. B1 ), enzyme activity of the reference standard (U B2 ).
[0126] 2.5 Calculation of enzyme activity retention rate:
[0127] Dextranase activity retention rate = U A1 / U A2 ×100%;
[0128] α-glucosidase activity retention rate = U B1 / U B2 ×100%.
[0129] 2.6 Test Results: The enzyme activity retention rate of the examples and comparative examples after 18 months at room temperature was measured using the above method. Specific test results are shown in Table 4.
[0130] Table 4 Summary of Enzyme Activity Retention Rate Test Results
[0131]
[0132] Note 1: The enzyme activity value obtained from the test on the first day after the toothpaste was placed at room temperature is the control enzyme activity (U) in the enzyme activity retention rate test. A2 ).
[0133] Based on the above test results, it can be seen that each embodiment has a high enzyme activity retention capacity. However, when the toothpaste components such as humectants, foaming agents, and abrasives exceed the scope of this technical solution, the enzyme activity of the toothpaste product will be greatly reduced.
[0134] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0135] The embodiments described above are merely illustrative of several implementation methods of this application, intended to facilitate a detailed understanding of the technical solutions of this application, but should not be construed as limiting the scope of protection of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the scope of protection of this application. It should be understood that technical solutions obtained by those skilled in the art based on the technical solutions provided in this application through logical analysis, reasoning, or limited experimentation are all within the scope of protection of the appended claims. Therefore, the scope of protection of this patent application should be determined by the content of the appended claims, and the specification can be used to interpret the content of the claims.
Claims
1. An oral care composition comprising an enzyme, characterised in that, by weight percent, comprising: an enzyme composition 0.4%~2%, a cationic bactericide 0.03%~0.3%, a humectant 20%~80%, a foaming agent 1.5%~5%, and an abrasive 15%~75%; wherein the enzyme composition comprises dextranase and alpha-glucosidase; the humectant comprises polyethylene glycol having an average molecular weight greater than or equal to 300 g / mol, the polyethylene glycol being present in the enzyme-containing oral care paste composition in an amount greater than or equal to 5% by weight; the foaming agent comprises one or more of non-ionic surfactant and zwitterionic surfactant, optionally anionic surfactant, the anionic surfactant being present in the enzyme-containing oral care paste composition in an amount less than or equal to 1% by weight; the abrasive comprises silicon dioxide.
2. The enzyme-containing oral care paste composition according to claim 1, characterized in that, the enzyme-containing oral care paste composition comprises the dextranase in an amount of 0.3%~1% by weight and the alpha-glucosidase in an amount of 0.1%~1% by weight; optionally, the dextranase has an enzyme activity of greater than 30000 U / g; optionally, the alpha-glucosidase has an enzyme activity of greater than 2500 U / g; optionally, the enzyme-containing oral care paste composition comprises the dextranase in an amount of 0.4%~0.8% by weight; optionally, the enzyme-containing oral care paste composition comprises the alpha-glucosidase in an amount of 0.2%~0.6% by weight.
3. The enzyme-containing oral care paste composition of claim 1, wherein, the cationic bactericide comprises one or more of cetylpyridinium chloride, domiphen bromide and chlorhexidine.
4. The enzyme-containing oral care paste composition of claim 1, wherein, the enzyme-containing oral care paste composition comprises the cationic bactericide in an amount of 0.1%~0.16% by weight.
5. The enzyme-containing oral care paste composition according to any one of claims 1 to 4, characterized in that, the non-ionic surfactant comprises one or more of lauryl glucoside, poloxamer and polyoxyethylene hydrogenated castor oil.
6. The enzyme-containing oral care paste composition according to any one of claims 1 to 4, characterized in that, the zwitterionic surfactant comprises one or more of cocamidopropyl betaine, sodium lauroyl methyl taurate and sodium lauroyl methyl taurate.
7. The enzyme-containing oral care paste composition according to any one of claims 1 to 4, wherein the enzyme is a protease. the anionic surfactant comprises sodium lauryl sulfate.
8. Toothpaste, characterized in that, the enzyme-containing oral care paste composition of any one of claims 1~7.
9. The toothpaste according to claim 8, characterized in that, the functional adjuvant comprises one or more of fragrance, thickening agent, preservative, taste-modifying agent and appearance-modifying agent.
10. Use of the enzyme-containing oral care paste composition of any one of claims 1~7 or the toothpaste of any one of claims 8~9 in the manufacture of a preparation for the removal of dental plaque.