An optical path difference control system

Abstract

The application relates to the technical field of ophthalmic medical equipment, and discloses a light path difference regulation system which comprises a light source module, a light path regulation module, an optical projection module, a neural adaptation detection module and a central control module; the light path regulation module and the neural adaptation detection module are arranged, the light path difference dynamic modulation is applied to ophthalmic treatment, the problem is solved from the trigger source of neural adaptation by changing the phase distribution mode of retinal light stimulation, the problem is indirectly relieved by adjusting the intensity or frequency, and the adjustment of the modulation parameters is based on the detection result of the neural adaptation detection module, so that the modulation is effective and does not cause additional discomfort; feedback control is completed through the central control module, a closed-loop system of detection-feedback-adjustment is realized, the modulation parameters can be dynamically optimized and adjusted according to the individual neural adaptation degree, and the individualization level of treatment can be effectively improved.

Description

Technical Field

[0001] This invention relates to the field of ophthalmic medical device technology, and more specifically to an optical path difference control system. Background Technology

[0002] In ophthalmological clinical treatment, visual training based on light stimulation, such as amblyopia treatment and visual function rehabilitation, often relies on repetitive light signal input to the retina or visual cortex. However, the nervous system has the characteristic of "neural adaptation." When exposed to a fixed pattern of light stimulation for a long time, neurons will gradually become less sensitive to the stimulation, i.e., an adaptation phenomenon will occur, which will lead to the decay of the treatment effect over time. When retinal or visual cortex nerve cells are subjected to the same or similar stimulation for a long time, their response to the stimulation will gradually weaken. This phenomenon can lead to eye diseases such as decreased vision and visual fatigue.

[0003] In the existing technology, the treatment methods for eye diseases mainly include drug treatment, surgical treatment and optical correction. They usually alleviate adaptation by increasing the intensity of stimulation or changing the stimulation pattern. However, the former may cause the risk of light damage, and the latter cannot fundamentally change the triggering mechanism of neural adaptation.

[0004] In view of this, the present invention proposes an optical path difference control system, which dynamically controls the optical path difference incident on the retina to change the spatial phase distribution pattern of light stimulation, thereby inhibiting retinal or visual cortex neural adaptation and solving the problem of efficacy decay caused by neural adaptation in existing light stimulation therapy. Summary of the Invention

[0005] In order to overcome the above-mentioned defects of the prior art, the present invention provides an optical path difference control system to solve the problems existing in the background art.

[0006] This invention provides the following technical solution: an optical path difference control system, comprising a light source module, an optical path difference control module, an optical projection module, a neural adaptation detection module, and a central control module;

[0007] The light source module is used to emit coherent light of a specific wavelength, and is marked as the emitted light;

[0008] The optical path control module is used to receive the emitted light emitted by the light source module and dynamically modulate the optical path of the emitted light to obtain modulated light.

[0009] The optical projection module is used to collimate and focus the light modulated by the optical path control module onto the target area of ​​the patient's retina.

[0010] The neural adaptation detection module is used to monitor the neural response of the retina or visual cortex in real time and obtain feedback signals of the degree of adaptation and attenuation rate.

[0011] The central control module is used to obtain the required optical path difference modulation parameters by receiving feedback signals from the neural adaptation detection module, and to send control commands to the optical path adjustment module.

[0012] Preferably, the neural adaptation detection module includes an eye-tracking unit and an electrophysiological detection unit; the eye-tracking unit is used to monitor corneal reflective light spots using an infrared camera, locate the pupil center and fixation point, and ensure that light stimulation is accurately projected onto the target area; the electrophysiological detection unit is used to collect electroretinal images and visual evoked potentials through electrodes attached to the periorbital area, and extract the amplitude attenuation rate and adaptation value of the neural response.

[0013] Preferably, the light source module uses a single-frequency laser as the light source; the target area is the eye area that needs to be treated; the emitted light includes wavelengths... Near-infrared light and wavelength Visible light; the dynamic modulation is performed using a spatial light phase modulator.

[0014] Preferably, the optical path control module dynamically modulates the optical path of the emitted light as follows:

[0015] ;in, Point In time The dynamic modulation component of the optical path difference, This represents the modulation amplitude, i.e., a multiple of the wavelength, and its value ranges from [value missing]. , Indicates the wavelength of the emitted light; Indicates time, Retina pixel coordinates on the axis Retina Pixel coordinates on the axis; This represents the modulation angular frequency, with a value range of [value missing]. ; Represents the spatial modulation wavenumber, with a value range of 1000. .

[0016] Preferably, the spatial light phase modulator is a reflective liquid crystal phase modulator, which changes the orientation of liquid crystal molecules by applying a pixel-level voltage to the liquid crystal layer, thereby changing the refractive index distribution of the liquid crystal layer, and ultimately causing a spatially differentiated change in the phase delay of the incident light.

[0017] The relationship between the phase delay and the optical path difference is expressed as follows:

[0018] ;in, Indicates that the spatial optical phase modulator is in The equivalent optical path difference introduced at the location; Indicates in Phase delay at that point ;in, express Voltage at that point This represents the half-wave voltage of the spatial light phase modulator, even if the phase delay reaches... The voltage of the radian; the spatial optical phase modulator converts the electrical signal into a phase delay through pixel-level voltage control, which is equivalent to dynamic modulation of the spatial optical path difference.

[0019] Preferably, the obtained modulated light specifically refers to:

[0020] Obtain the initial optical path difference ;

[0021] The total optical path difference is obtained by superimposing the initial optical path difference with the dynamic modulation component of the optical path difference.

[0022] ;in, Indicates the total optical path difference;

[0023] Based on the total optical path difference, the dynamic light intensity distribution on the retina is obtained through the relationship between light intensity and phase.

[0024] Preferably, the initial optical path difference is the initial optical path difference distribution at system startup. Based on the equivalence between phase and optical path difference, the initial optical path difference is determined by the initial phase distribution, expressed by the formula:

[0025] ;in, This represents the initial phase distribution; the initial phase distribution is a one-dimensional sinusoidal distribution. ;in, This represents the initial spatial frequency, i.e., the number of cycles per millimeter;

[0026] The total optical path difference corresponds to the phase distribution on the retina as follows: ;

[0027] The dynamic light intensity distribution on the retina can be expressed by the formula:

[0028] ;in, Point In time The dynamic light intensity distribution.

[0029] Preferably, the neural adaptation detection module acquires the adaptation degree and decay rate feedback signals specifically as follows:

[0030] The responses of the retina and visual cortex are acquired through electroretinography and visual evoked potentials by the electrophysiological detection unit; the degree of adaptation and attenuation rate feedback signals are represented by the amplitude attenuation rate and degree of adaptation values ​​of the neural response.

[0031] The amplitude attenuation rate is expressed as: ;in, Indicates time Amplitude attenuation rate at that time; Indicates the initial amplitude. Indicates the current amplitude. Indicates the duration of stimulation;

[0032] The fitness level value is expressed as: ;in, This indicates the degree of adaptation.

[0033] Preferably, the central control module receives feedback signals from the neural adaptation detection module to obtain the required optical path difference modulation parameters, specifically as follows:

[0034] The amplitude attenuation rate and the degree of adaptation are compared with a preset threshold, and the modulation parameters are adjusted according to the comparison results.

[0035] The target phase delay of each pixel is obtained based on the adjusted parameters; expressed by the formula:

[0036] ;in, Indicates the target phase delay; Indicates the initial phase delay;

[0037] The target phase delay of each pixel is converted into a pixel voltage value, which forms a control command and is sent to the driving circuit to drive the liquid crystal molecules of each pixel to change their orientation, thereby achieving precise modulation of dynamic optical path difference.

[0038] The technical effects and advantages of this invention are as follows:

[0039] This invention, by incorporating an optical path adjustment module and a neural adaptation detection module, facilitates the application of dynamic modulation of optical path difference in ophthalmic treatment. By altering the phase distribution pattern of retinal light stimulation, it addresses the problem at its source—the triggering of neural adaptation—rather than merely providing indirect relief through intensity or frequency adjustments. Furthermore, all adjustments to modulation parameters are based on the detection results from the neural adaptation detection module, ensuring effective modulation without causing additional discomfort. A central control module completes a feedback control closed loop, realizing a detection-feedback-adjustment closed-loop system. The modulation parameters can be dynamically optimized and adjusted according to the individual's degree of neural adaptation, thereby effectively improving the personalization of treatment. Attached Figure Description

[0040] Figure 1This is a flowchart of the optical path difference control system of the present invention. Detailed Implementation

[0041] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. In addition, the forms of the various structures described in the following embodiments are merely illustrative. The optical path difference control system involved in the present invention is not limited to the structures described in the following embodiments. All other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0042] Example 1

[0043] like Figure 1 As shown, the present invention provides an optical path difference control system, including a light source module, an optical path difference control module, an optical projection module, a neural adaptation detection module, and a central control module; the light source module emits coherent light, which is modulated by the optical path difference by the optical path difference control module and then focused by the optical projection module onto the target area of ​​the retina; the neural adaptation detection module monitors the neural response in real time; and the central control module adjusts the optical path difference modulation parameters according to the feedback.

[0044] The light source module is used to emit coherent light of a specific wavelength, which is labeled as the emitted light; the preferred wavelength of the emitted light is... Near-infrared light or wavelength Visible light is used to balance retinal penetration and safety; the light source module uses a single-frequency laser as the light source, such as a semiconductor laser, with a linewidth less than or equal to... To ensure that the coherence meets the optical path difference modulation requirements;

[0045] The optical path control module is used to receive the emitted light from the light source module and dynamically modulate the optical path of the emitted light to obtain modulated light. Its purpose is to make the light stimulation pattern on the retina change periodically with time and space, thereby breaking the stable adaptive state of neurons. The dynamic modulation is performed using a spatial light phase modulator. In this embodiment, a reflective liquid crystal phase modulator is selected with a resolution ≥1920×1080 and a pixel size ≤5μm. The phase delay of each pixel can be adjusted independently. By changing the phase of different pixels, it is equivalent to introducing a controllable optical path difference in the spatial dimension.

[0046] The optical projection module is used to collimate and focus the light modulated by the optical path control module onto the target area of ​​the patient's retina, which is the eye area that needs to be treated. The optical projection module includes a collimating lens, a scanning galvanometer, and an eyepiece system. The focal length of the collimating lens is selected as 50mm, NA=0.1, and the scanning galvanometer has a scanning frequency greater than or equal to 1kHz for quickly switching the stimulation position.

[0047] The neural adaptation detection module is used to monitor the neural response of the retina or visual cortex in real time and obtain feedback signals of adaptation degree and attenuation rate. The neural adaptation detection module includes an eye-tracking unit and an electrophysiological detection unit. The eye-tracking unit is used to monitor the corneal reflected light spot with an infrared camera, locate the pupil center and fixation point to ensure that the light stimulus is accurately projected onto the target area. The electrophysiological detection unit is used to collect electroretinograms and visual evoked potentials through electrodes attached to the periorbital area, and extract the amplitude attenuation rate and adaptation degree value of the neural response.

[0048] The central control module is used to receive feedback signals from the neural adaptation detection module through an integrated FPGA+ARM processor, obtain the required optical path difference modulation parameters, and send control commands to the optical path control module; its purpose is to maintain the degree of neural adaptation below a preset threshold.

[0049] In this embodiment, it should be specifically noted that the dynamic modulation of the optical path of the emitted light by the optical path control module is represented as follows:

[0050] ;in, Point In time The dynamic modulation component of the optical path difference is a modulation component that varies with time and space. Its purpose is to make the stimulation pattern on the retina "move" and prevent neurons from forming a stable adaptive state. This represents the modulation amplitude, i.e., a multiple of the wavelength, and its value ranges from [value missing]. , The larger the optical path difference, the more drastic the change, and the faster the stimulus pattern changes. When, phase delay change That is, a complete cycle corresponds to the light intensity distribution changing from cosine to negative cosine, ensuring the reversal of the stimulation pattern; Indicates the wavelength of the emitted light; Indicates time, Retina pixel coordinates on the axis Retina Pixel coordinates on the axis; This represents the modulation angular frequency, with a value range of [value missing]. To control the time scale of changes in stimulus patterns, if If the modulation is too slow, the neurons can still adapt. If the stimulus changes too quickly, it can cause visual fatigue; Represents the spatial modulation wavenumber, with a value range of 1000. To control the spatial direction of the stimulus pattern change, a phase gradient in the y-axis direction is introduced, causing the grating pattern on the retina to translate along the y-axis.

[0051] In this embodiment, it should be specifically noted that the spatial light phase modulator is the core of the optical path control module. The purpose of selecting the reflective liquid crystal phase modulator is to change the orientation of liquid crystal molecules by applying a pixel-level voltage to the liquid crystal layer based on the electro-optic effect of liquid crystal, thereby changing the refractive index distribution of the liquid crystal layer, and ultimately causing the phase delay of the incident light to change spatially.

[0052] The relationship between the phase delay and the optical path difference is expressed as follows:

[0053] ;in, Indicates that the spatial optical phase modulator is in The equivalent optical path difference introduced at the location; Indicates in The phase delay at that point is determined by the voltage modulation of the liquid crystal layer. ;in, express Voltage at that point This represents the half-wave voltage of the spatial light phase modulator, even if the phase delay reaches... The voltage of the arc is typically a few volts to tens of volts; the spatial optical phase modulator converts the electrical signal into a phase delay through pixel-level voltage control, which is equivalent to dynamic modulation of the spatial optical path difference.

[0054] In this embodiment, it should be specifically noted that the modulated light obtained is as follows:

[0055] Obtain the initial optical path difference The initial optical path difference is the initial optical path difference distribution when the system starts up, used to form a periodic basic stimulus on the retina; according to the equivalence relationship between phase and optical path difference, the initial optical path difference is determined by the initial phase distribution, expressed by the formula:

[0056] ;in, This represents the initial phase distribution; in order to generate sinusoidal grating stimulation on the retina, the initial phase distribution is taken as a one-dimensional sinusoidal distribution. ;in, This represents the initial spatial frequency, i.e., the number of cycles per millimeter; therefore, the initial optical path difference can also be expressed as: Its purpose is to form a stable sinusoidal grating by using the initial optical path difference to correspond to the light intensity distribution on the retina. This is the basic stimulus for visual training and is used to activate retinal ganglion cells and visual cortex neurons.

[0057] The total optical path difference is obtained by superimposing the initial optical path difference with the dynamic modulation component of the optical path difference.

[0058] ;in, Indicates the total optical path difference;

[0059] The corresponding phase distribution on the retina is as follows: ;

[0060] Based on the total optical path difference and the relationship between light intensity and phase, the dynamic light intensity distribution on the retina can be obtained; expressed by the formula:

[0061] ;in, Point In time The dynamic light intensity distribution; the light intensity distribution on the retina changes simultaneously with time and space. The term reflects the time dimension, causing the light intensity distribution to be frequency-dependent. Periodic reversal, The item reflects the spatial dimension, causing the light intensity distribution to shift along the y-axis; its purpose is to use a time-dynamic light stimulation pattern to prevent retinal neurons from forming a "stable activation-adaptation" cycle, thereby fundamentally inhibiting neural adaptation.

[0062] In this embodiment, it should be specifically explained that the neural adaptation detection module acquires the adaptation degree and decay rate feedback signals in the following ways:

[0063] The electrophysiological detection unit collects the responses of the retina and visual cortex through electroretinography and visual evoked potentials. The electroretinography collects the electrical activity of retinal ganglion cells through periocular electrodes, and the amplitude reflects the degree of neuronal activation. The visual evoked potentials collect the electrical activity of the visual cortex through scalp electrodes, and the latency and amplitude reflect the response of higher visual pathways.

[0064] The adaptation degree and decay rate feedback signals are represented by the amplitude decay rate of the neural response and the adaptation degree value.

[0065] The amplitude attenuation rate is expressed as: ;in, Indicates time Amplitude attenuation rate at that time; Indicates the initial amplitude. Indicates the current amplitude. Indicates the duration of stimulation;

[0066] The fitness level value is expressed as: ;in, The initial amplitude and the current amplitude can be selected from either the amplitude of electroretinogram or the amplitude of visual evoked potential. That is, the initial amplitude and the current amplitude can be the amplitude of electroretinogram or the amplitude of visual evoked potential. They can be set by those skilled in the art. This embodiment provides two methods but does not specifically limit the selection method of the specific amplitude.

[0067] In this embodiment, it should be specifically noted that the central control module receives the feedback signal from the neural adaptation detection module and obtains the required optical path difference modulation parameters as follows:

[0068] The amplitude attenuation rate and the degree of adaptation are compared with preset thresholds, and the modulation parameters are adjusted according to the comparison results; the preset thresholds include a first threshold, a second threshold, and a third threshold.

[0069] like This indicates over-adaptation, which increases the risk. The value or decrease The value; increase The value is used to enhance the change in optical path difference and reduce The value of slows down the modulation speed, making it harder for neurons to adapt;

[0070] like This indicates insufficient adaptation, so reduce The value or increase The value; decrease The value is used to reduce light intensity fluctuations, avoid discomfort, and increase... The value is used to speed up modulation and improve training efficiency;

[0071] The The first threshold, The second threshold; satisfy The satisfy In this embodiment, we select , ; and The specific value can be set by those skilled in the art within the range of values ​​according to the actual situation;

[0072] like This indicates that the neural adaptation level is within a safe range and no significant adjustments are needed.

[0073] like This indicates over-adaptation, and the modulation parameters must be adjusted immediately to enhance the variation in the stimulation pattern;

[0074] The This represents the third threshold, which satisfies... In this embodiment, we select ;

[0075] The target phase delay of each pixel is obtained based on the adjusted parameters; expressed by the formula:

[0076] ;in, Indicates the target phase delay; Indicates the initial phase delay;

[0077] The central control module converts the target phase delay of each pixel into a pixel voltage value, forms a control command, and sends it to the driving circuit to drive the liquid crystal molecules of each pixel to change their orientation, thereby achieving precise modulation of the dynamic optical path difference.

[0078] In this embodiment, it should be specifically noted that the adjustment of modulation parameters based on the comparison results can also be achieved by using an adaptive PID control algorithm to dynamically adjust the modulation parameters and output control commands.

[0079] The core formula of the adaptive PID control algorithm is expressed as follows:

[0080] ;

[0081] in, This represents the output of the PID controller, i.e., the total adjustment of the modulation parameters, corresponding to the modulation parameters. , , The sum of adjustments; This represents the scaling factor, used for rapid response to the current error. Indicates the integral coefficient, used to eliminate steady-state error and avoid... and If the value remains below the preset threshold for an extended period, The differential coefficients are used to predict error trends and prevent overshoot; in this embodiment, the coefficients are selected. , , ; Indicates error, i.e. or The difference between the error and the corresponding preset threshold; when the error is greater than 5%, the value can be increased. To expedite response and reduce To avoid integral saturation; when the error is less than or equal to 5%, it can be reduced To prevent oscillation, increase To accurately maintain the preset threshold.

[0082] In this embodiment, it should be specifically noted that the output of the PID controller is the total adjustment amount of the modulation parameter. Further allocation to specific modulation parameters is needed. , , Different parameters have different inhibitory effects on neural adaptation, specifically:

[0083] like It is necessary to strengthen inhibition at this time. Increase , Decrease , Increase ;

[0084] like It is necessary to weaken the inhibition at this time. Decrease , Increase , Decrease ;

[0085] The intensity of the change in optical path difference is determined. The larger the size, the faster the reversal of retinal light intensity distribution, and the more difficult it is for neurons to adapt to a fixed pattern; Determine the timescale of changes in stimulus patterns, reduce It will make modulation slower, suitable Just below the third threshold or In cases where a gentle adjustment is made just after exceeding the first threshold, increase It will make modulation faster and more suitable Significantly below the third threshold or Cases where the value is significantly below the second threshold and rapid correction is performed; Determines the spatial movement speed of the stimulus pattern, increasing This will cause the grating to translate faster, increasing the decoding difficulty for neurons and inhibiting adaptation.

[0086] Example 2

[0087] Several children with amblyopia, aged 6-10 years, and with corrected visual acuity of 0.5-0.8, were randomly selected and divided into two groups: a control group and an experimental group. The control group received traditional fixed grating stimulation at a frequency of 0.2 Hz and a light intensity of 100 cd / m². 2 The experimental group used the system proposed in this invention, with an 850nm semiconductor laser as the light source, a linewidth of 0.8MHz, an LCoS phase modulator, a resolution of 1920×1080, and a pixel size of 4mm. After 4 weeks of training, the control group's visual acuity improved by an average of 0.15 LogMAR, and the improvement decreased to 0.05 LogMAR in the 5th week, indicating significant adaptation. After 4 weeks of training, the experimental group's visual acuity improved by 0.22 LogMAR, and the improvement rate remained at 0.18 LogMAR in the 5th week, indicating that adaptation was suppressed.

[0088] Therefore, the optical path difference control system proposed in this invention can effectively suppress neural adaptation.

[0089] In conclusion, the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0090] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. An optical path difference modulation system, characterized by: The system comprises a light source module, a light path regulation module, an optical projection module, a neural adaptation detection module, and a central control module. The light source module is configured to emit coherent light of a specific wavelength, and is marked as outgoing light. The light path regulation module is configured to receive the outgoing light emitted by the light source module, dynamically modulate the light path of the outgoing light, and obtain modulated light. The dynamic modulation is performed by a spatial light phase modulator. The optical projection module is configured to collimate and concentrate the modulated light from the light path regulation module to a target area of the retina of a patient. The neural adaptation detection module is configured to monitor the neural response of the retina or visual cortex in real time, and obtain an adaptation degree and a decay rate feedback signal. The central control module is configured to receive the feedback signal from the neural adaptation detection module, obtain the required light path difference modulation parameter, and send a control instruction to the light path regulation module. The dynamic modulation of the light path of the outgoing light by the light path regulation module is represented as follows: ; wherein, represents a point at time ; and represents a modulation amplitude, i.e. a multiple of the wavelength, in the range of , represents a wavelength of the outgoing light; represents time, represents a pixel coordinate point on the retina axis, represents a pixel coordinate point on the retina axis; represents a modulation angular frequency in the range of ; represents a spatial modulation wave number in the range of ; The spatial light phase modulator is a reflective liquid crystal phase modulator. The phase delay and the light path difference are related as follows: ; wherein, represents the equivalent optical path difference introduced by the spatial light phase modulator at ; represents the amount of phase delay at ; ; wherein, represents the voltage at ; represents the half-wave voltage of the spatial light phase modulator, i.e. the voltage at which the phase delay reaches radians; the spatial light phase modulator translates an electrical signal into a phase delay, which in turn is equivalent to a dynamic modulation of the spatial optical path difference, by pixel-level voltage control. The modulated light is obtained as follows: Acquiring initial optical path difference ; The initial light path difference and the dynamic modulation component of the light path difference are superimposed to obtain a total light path difference. ; wherein represents the total optical path difference; Based on the total light path difference, the dynamic light intensity distribution on the retina is obtained through the relationship between light intensity and phase. The initial light path difference is the initial light path difference distribution when the system is started. ; wherein, represents an initial phase distribution; the initial phase distribution takes a one-dimensional sinusoidal distribution; ; wherein, represents an initial spatial frequency, i.e., the number of cycles per millimeter; The total optical path difference corresponds to a phase distribution on the retina of: ; The dynamic light intensity distribution on the retina is represented by the following formula: ; wherein, representing a point at a time dynamic light intensity distribution; The neural adaptation detection module obtains the adaptation degree and the decay rate feedback signal as follows: The responses of the retina and the visual cortex are collected through the electroretinogram and the visual evoked potential of the electrophysiological detection unit. The amplitude decay rate is expressed as: ; wherein, represents the time at which the amplitude decay rate is determined; represents the initial amplitude, represents the current amplitude, represents the stimulation time; The fitness value is represented as: ; wherein, represents the fitness value; The adaptation degree and the decay rate feedback signal are represented by the amplitude decay rate and the adaptation degree value of the neural response. The central control module receives the feedback signal from the neural adaptation detection module to obtain the required light path difference modulation parameter as follows: The amplitude decay rate and the adaptation degree value are compared with the preset threshold, and the modulation parameter is adjusted according to the comparison result. ; wherein, represents a target phase delay; represents an initial phase delay; The target phase delay of each pixel is obtained according to the adjusted parameter, and is represented by the following formula:

2. The optical path difference control system according to claim 1, wherein: The target phase delay of each pixel is converted into a pixel voltage value to form a control instruction, which is sent to the driving circuit to change the orientation of the liquid crystal molecules of each pixel, thereby achieving accurate modulation of the dynamic light path difference. The neural adaptation detection module comprises an eye movement tracking unit and an electrophysiological detection unit. The eye movement tracking unit is configured to monitor the corneal reflection spot using an infrared camera, locate the pupil center and the fixation point, and ensure that the light stimulus is accurately projected to the target area. The electrophysiological detection unit is configured to collect the electroretinogram and the visual evoked potential through the electrodes attached to the eye, and extract the amplitude decay rate and the adaptation degree value of the neural response.

3. The optical path difference control system according to claim 2, wherein: The light source module adopts a single-frequency laser as a light source; the target region is an eye region requiring treatment; and the emitted light includes near-infrared light with a wavelength of 800-950 nm and visible light with a wavelength of 550-650 nm.

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