Real-time dose monitoring system and method for boron neutron capture therapy device

Abstract

The invention relates to the technical field of data real-time monitoring, in particular to a real-time dose monitoring system and method for a boron neutron capture therapy device. The method comprises the steps that a main detector and an auxiliary detector are divided, the positions of the detectors are arranged, the neutron dose of each position is monitored in real time, and a multi-layer shielding structure is configured for the detectors; collecting six paths of redundant signals, and transmitting the redundant signals; according to the equipment connection and communication state, the dosage and the time monitoring data, the beam stopping condition is judged, and beam stopping reason data is obtained; calibrating a scale factor of the detector, and performing grading processing according to deviation data; storing real-time monitoring data, executing a calling request, and tracing a treatment process; the system comprises a detection deployment and shielding optimization module, a redundant signal acquisition module, a beam stop logic judgment module, a calibration and deviation processing module and a data tracing module. By means of the mode, the reliability and accuracy of real-time dose monitoring in boron neutron capture therapy are improved.

Description

Technical Field

[0001] This invention relates to the field of real-time data monitoring technology, and in particular to a real-time dose monitoring system and method for a boron neutron capture therapy device. Background Technology

[0002] Radiotherapy is a crucial method for cancer treatment, primarily encompassing three categories: proton and heavy ion therapy, photon therapy, and neutron therapy. For irregular, diffuse tumors, photon and proton / heavy ion therapies struggle to guarantee efficacy. Boron neutron capture therapy (BNCT), with its advantage of "targeted destruction of cancer cells," has become a focus of radiotherapy research. BNCT equipment typically uses a beam current of 10mA to 30mA, producing radioactivity far exceeding that of UV-level heavy ion and photon therapies. Therefore, real-time dose monitoring is essential to ensure the equipment executes the treatment plan correctly. Key requirements include: accurately achieving normal beam termination and implementing abnormal beam termination through redundant design when normal termination logic fails.

[0003] Existing online dose monitoring for BNCT has significant drawbacks: conventional low-sensitivity detectors (such as semiconductor and scintillator detectors) have poor radiation resistance and are prone to damage during long-term online monitoring, resulting in low reliability; while gas proportional counters (such as neutron tubes) are readily available and resistant to strong radiation, their high sensitivity makes them prone to signal blockage when applied to accelerator BNCT, compromising accuracy.

[0004] Therefore, it is essential to develop a highly reliable and accurate real-time dose monitoring system and method for boron neutron capture therapy devices. Summary of the Invention

[0005] The purpose of this invention is to provide a real-time dose monitoring system and method for a boron neutron capture therapy device, aiming to improve the reliability and accuracy of real-time dose monitoring in boron neutron capture therapy.

[0006] To achieve the above objectives, the present invention provides a real-time dose monitoring method for a boron neutron capture therapy device, comprising the following steps: The detectors are divided into main and auxiliary detectors, and their positions are arranged. The neutron dose at each position is monitored in real time, and a multi-layer shielding structure is configured for the detectors. It acquires six redundant signals: three from detectors, one from DCCT, one from time, and one from device status, and transmits the redundant signals. The cause of the beam stoppage is determined based on the device connection and communication status, dose and time monitoring data; The detector scaling factor is calibrated, and the deviation data is graded accordingly. Store real-time monitoring data and execute retrieval requests to trace the treatment process.

[0007] Among the steps are: dividing the detector into main and auxiliary detectors, arranging their positions, monitoring the neutron dose at each position in real time, and configuring a multi-layer shielding structure for the detectors; Two He-3 neutron detectors are set as the main detectors, and one He-3 neutron detector is set as the auxiliary detector. The detector is equipped with a multi-layer shielding structure, consisting of a 1mm thick cadmium sheet with 20% area perforations, a 5mm thick lead sheet, and a 1cm thick boron-containing polyethylene sheet containing 50% boron carbide, from the inside out.

[0008] In the step of setting two He-3 neutron detectors as the main detectors and one He-3 neutron detector as the auxiliary detector: The main detector is deployed at the neutron beam exit, and the secondary detector is deployed on the proton target recoil path.

[0009] The process involves acquiring six redundant signals—three from detectors, one from a DCCT, one from time, and one from device status—and transmitting these redundant signals. Identify the target for acquiring the six redundant signals; Establish a signal acquisition link to acquire detector signals, DCCT signals, time signals, and device status signals respectively; Select the transmission medium for the signal; Establish a signal transmission path to transmit detector signals to a multi-channel processor, and transmit DCCT signals, time signals, and equipment status signals to an industrial control computer. Simultaneously, perform signal interaction between the industrial control computer and ACS, TCS, and SIS.

[0010] In the step of determining the acquisition targets of the six redundant signals: The data acquisition targets are the neutron count rate and cumulative dose signals of three He-3 neutron detectors, the instantaneous current and cumulative charge signals of the accelerator beam of one DCCT, the treatment time signal generated by one industrial control computer, and the equipment status signal that monitors the connection status of the detectors and multi-channel processors and the status of the external communication links.

[0011] In the step of selecting a transmission medium for the signal: The detector signal is pre-amplified and then transmitted through a radiation-resistant connection cable with a length greater than 20m. The DCCT signal, time signal, and equipment status signal are transmitted through a CAT6 network cable.

[0012] Among the steps, in determining the beam stoppage situation based on device connection and communication status, dose and time monitoring data, and obtaining data on the cause of beam stoppage: Check the device connection status. If any detector or multichannel processor is not connected, mark the device connection as abnormal. Check the external communication status. If there is any abnormality in the network port communication between the industrial control computer and DCCT, TCS, or SIS, record the communication abnormality information. It receives treatment parameters from TCS. When the main detector count rate exceeds the set threshold, it uses the industrial control computer to time and accumulate the treatment dose. Determine the termination status based on monitoring data.

[0013] In the step of determining the jogging stop status based on monitoring data: When the cumulative dose to the main detector reaches 100% of the target dose, it is determined to be a normal beam stop. When abnormal conditions occur, it is determined to be an abnormal termination of the treatment, and the corresponding termination reason data is recorded. Abnormal conditions include DCCT cumulative charge reaching 110% of the target charge, treatment time reaching 120% of the expected time, and DCCT instantaneous current exceeding the predetermined value by 200%.

[0014] Among them, in the steps of calibrating the detector scaling factor and performing graded processing based on the deviation data: Perform calibration, measure the activation rate of gold foil three times repeatedly, remove outliers, and calculate the average activation rate of gold foil. Calculate the detector scaling factor, and combine it with the preset calibration factor and the average activation rate of the gold foil to obtain the calibration scaling factor of the three detectors for the day. The deviation data is calculated by comparing the average total count of the three detectors on the current day with the average total count of the previous day to obtain the percentage of count deviation, and then classifying and processing the data according to the percentage of deviation.

[0015] This invention also provides a real-time dose monitoring system for a boron neutron capture therapy device, comprising a detection deployment and shielding optimization module, a redundant signal acquisition module, a beam stop logic judgment module, a calibration and deviation processing module, and a data traceability module; wherein: The detection deployment and shielding optimization module is used to divide the main detector and the auxiliary detector, arrange the detector positions, monitor the neutron dose at each position in real time, and configure a multi-layer shielding structure for the detector. The redundant signal acquisition module is used to acquire six redundant signals, including three detector signals, one DCCT signal, one time signal, and one device status signal, and to transmit the redundant signals. The beam stop logic judgment module is used to determine the beam stop situation based on the device connection and communication status, dose and time monitoring data, and to obtain beam stop reason data; The calibration and deviation processing module is used to calibrate the detector scaling factor and perform graded processing based on the deviation data. The data traceability module is used to store real-time monitoring data and execute retrieval requests to trace the treatment process.

[0016] This invention discloses a real-time dose monitoring system and method for a boron neutron capture therapy device. The system comprises a detector deployment and shielding optimization module, a redundant signal acquisition module, a beam stop logic judgment module, a calibration and deviation processing module, and a data traceability module, performing the following steps: dividing the device into a main detector and a secondary detector, arranging the detector positions, monitoring the neutron dose at each position in real time, and configuring a multi-layer shielding structure for the detectors; acquiring six redundant signals—three from the detectors, one from the DCCT, one from the time, and one from the device status—and transmitting these redundant signals; determining the beam stop situation based on the device connection and communication status, dose, and time monitoring data, and obtaining the cause data for beam stoppage; calibrating the detector scaling factor and performing graded processing based on the deviation data; storing the real-time monitoring data and executing retrieval requests to trace the treatment process; thereby improving the reliability and accuracy of real-time dose monitoring in boron neutron capture therapy. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a flowchart of the steps of the real-time dose monitoring method for a boron neutron capture therapy device according to the present invention.

[0019] Figure 2 This is a flowchart of steps S100 of the present invention.

[0020] Figure 3 This is a flowchart of steps S200 of the present invention.

[0021] Figure 4 This is a flowchart of steps S300 of the present invention.

[0022] Figure 5 This is a flowchart of steps S400 of the present invention.

[0023] Figure 6 This is a flowchart of steps S500 of the present invention.

[0024] Figure 7 This is a schematic diagram of the real-time dose monitoring system for a boron neutron capture therapy device according to the present invention.

[0025] Figure 8 This is a schematic diagram of the electronic device of the present invention.

[0026] 601-Detection deployment and shielding optimization module, 602-Redundant signal acquisition module, 603-Beam stop logic judgment module, 604-Calibration and deviation processing module, 605-Data traceability module. Detailed Implementation

[0027] Exemplary embodiments will now be described in detail, examples of which are illustrated in the accompanying drawings. When the following description relates to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with this application.

[0028] The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The singular forms “a,” “the,” and “the” used in this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term “and / or” as used herein refers to and includes any or all possible combinations of one or more of the associated listed items.

[0029] It should be understood that although the terms first, second, third, etc., may be used in this application to describe various information, such information should not be limited to these terms. These terms are only used to distinguish information of the same type from one another. For example, without departing from the scope of this application, first information may also be referred to as second information, and similarly, second information may also be referred to as first information. Depending on the context, the word "if" as used herein may be interpreted as "when," "when," or "in response to determination."

[0030] Please see Figures 1-6 The present invention provides a real-time dose monitoring method for a boron neutron capture therapy device, comprising the following steps: S100: Divide the detector into main detector and auxiliary detector, arrange the detector positions, monitor the neutron dose at each position in real time, and configure a multi-layer shielding structure for the detector.

[0031] In this embodiment, a main detector and a secondary detector are defined, their positions are arranged, the neutron dose at each position is monitored in real time, and a multi-layered shielding structure is configured for the detectors. The specific process is as follows: S101: Two He-3 neutron detectors are set as the main detectors, and one He-3 neutron detector is set as the auxiliary detector; the main detectors are deployed at the neutron beam exit, and the auxiliary detectors are deployed on the proton target recoil path; S102: The detector is equipped with a multi-layer shielding structure, consisting of a 1mm thick cadmium sheet with 20% area perforations, a 5mm thick lead sheet, and a 1cm thick boron-containing polyethylene sheet containing 50% boron carbide.

[0032] In the above process, the division and deployment of main and auxiliary detectors are as follows: three He-3 neutron detectors are selected, two of which are designated as main detectors (responsible for core dose monitoring) and one as an auxiliary detector (to assist in monitoring and improve redundancy); combined with the structure of the BNCT neutron target station and the characteristics of the beam, the main detector is deployed at the neutron beam exit (to directly monitor the dose in the core region of the treatment beam), and the auxiliary detector is deployed on the proton firing recoil path (to monitor the recoil neutron dose during firing and achieve multi-angle coverage).

[0033] Detector multi-layer shielding structure configuration: To solve the problem of signal blockage in high-sensitivity He-3 neutron tubes, all detectors are equipped with a three-layer shielding structure, from the inside out: a 1mm thick cadmium sheet with small holes of 20% area (for initial neutron filtering and control of neutron incidence), a 5mm thick lead sheet (to enhance neutron scattering and further reduce neutron flux), and a 1cm thick boron-containing polyethylene sheet containing 50% boron carbide (for final neutron attenuation and ensuring that the detector response is within the appropriate range).

[0034] S200: Acquires six redundant signals from three detectors, one DCCT, one time, and one device status, and transmits the redundant signals.

[0035] In this embodiment, six redundant signals are acquired, including three from detectors, one from a DCCT, one from time, and one from device status, and these redundant signals are transmitted. The specific process is as follows: S201: Determine the acquisition targets of the six redundant signals; the acquisition targets are the neutron count rate and cumulative dose signals of three He-3 neutron detectors, the instantaneous current and cumulative charge signals of the accelerator beam of one DCCT, the treatment time signal generated by the industrial control computer, and the equipment status signal that monitors the connection status of the detector and the multi-channel processor and the status of the external communication link. S202: Establish a signal acquisition link to acquire detector signals, DCCT signals, time signals, and device status signals respectively; S203: Select the transmission medium for the signal; the detector signal is pre-amplified and then transmitted through a radiation-resistant connection cable with a length >20m; the DCCT signal, time signal, and equipment status signal are transmitted through a CAT6 network cable. S204: Establish a signal transmission path to transmit detector signals to the multichannel processor, DCCT signals, time signals, and equipment status signals to the industrial control computer, and simultaneously perform signal interaction between the industrial control computer and ACS, TCS, and SIS.

[0036] In the above process, the redundant signal acquisition objects are determined: the specific sources and monitoring contents of the six redundant signals are clarified, namely: the neutron count rate (real-time reflection of beam intensity) and cumulative dose (statistical total treatment dose) signals of three He-3 neutron detectors, the instantaneous current of the accelerator beam (monitoring real-time beam stability) and cumulative charge (assisting in judging the total beam volume) signals of one DCCT (direct current sensor), the treatment time signal generated by the industrial control computer (recording treatment duration), and the equipment status signal (monitoring the connection status between the detector and the multichannel processor, and the communication link status between the industrial control computer and the external system).

[0037] Signal acquisition link setup: Dedicated acquisition links are set up for different signal types. The detector's count rate and cumulative dose signals are obtained through the detector's built-in signal acquisition device. The beam current and electrical signals are extracted using the DCCT dedicated data acquisition interface. The treatment time signal is generated using the high-precision timing device built into the industrial control computer. The connection status of the detector and multi-channel processor and the communication link status are captured in real time by the equipment status monitoring sensor.

[0038] Transmission medium selection: The appropriate medium is selected based on the signal characteristics and transmission environment. The detector signal is amplified by the preamplifier circuit and then transmitted through a radiation-resistant connection cable with a length of >20m (to adapt to high-radiation treatment environments and reduce signal attenuation). DCCT signals, time signals, and equipment status signals are transmitted through CAT6 network cables (to meet the requirements of high-speed and stable data interaction and to adapt to the conventional communication environment in the computer room).

[0039] Transmission path establishment: A clear signal transmission path is planned, and the detector signal is transmitted to the multi-channel processor for preliminary signal processing; DCCT signal, time signal, and equipment status signal are directly transmitted to the industrial control computer (core data processing unit); at the same time, a two-way signal interaction channel is established between the industrial control computer and ACS (accelerator control system), TCS (treatment control system), and SIS (safety interlock system) to ensure that monitoring data can be uploaded to the control terminal in real time and control commands can be issued to the execution terminal in a timely manner.

[0040] S300: Determines the cause of beam stoppage based on device connection and communication status, dose and time monitoring data, and obtains the cause of beam stoppage data.

[0041] In this embodiment, the termination of the beam is determined based on the device connection and communication status, dose and time monitoring data, and the cause data of the termination is obtained. The specific process is as follows: S301: Check the device connection status. If any detector or multichannel processor is not connected, mark the device connection as abnormal. S302: Check the external communication status. If there is a problem with the network communication between the industrial control computer and DCCT, TCS, or SIS, record the communication error information. S303: Receives treatment parameters from TCS. When the main detector count rate exceeds the set threshold, it uses the industrial control computer to time and accumulate the treatment dose. S304: Determine the termination status based on monitoring data; when the cumulative dose of the main detector reaches 100% of the target dose, it is determined to be a normal termination; when abnormal conditions occur, it is determined to be an abnormal termination, and the corresponding termination reason data is recorded. Abnormal conditions include the DCCT cumulative charge reaching 110% of the target charge, the treatment time reaching 120% of the expected time, and the DCCT instantaneous current exceeding the predetermined value by 200%.

[0042] During the above process, the device connection status is checked: the connection status of the three detectors and the three multi-channel processors is checked periodically. If any detector or multi-channel processor is found to be disconnected or interrupted, it is immediately marked as a device connection abnormality and a preliminary alarm is triggered.

[0043] External communication status check: Real-time verification of the network port communication status between the industrial control computer and DCCT, TCS, and SIS. Confirm whether the communication link is smooth through interactive test frames. If there are problems such as data interaction delay, packet loss, or interruption, record the communication abnormality information (including abnormal system, abnormal time, and abnormal type) in a timely manner.

[0044] Treatment parameter reception and monitoring start-up: Receive treatment parameters (including expected treatment time, target dose, target charge, detector scaling factor, etc.) issued by TCS. After the parameters are verified to be correct, monitor the count rate of the main detector in real time. When the count rate of the main detector exceeds the preset threshold (indicating that the beam current has reached the intensity required for treatment), the industrial control computer automatically starts the timing function and dose accumulation calculation function.

[0045] Beam stop judgment and cause recording: The type of beam stop is determined based on real-time monitoring data. When the cumulative dose of the main detector (any main detector) reaches 100% of the target dose, it is determined to be a normal beam stop, and the cause of beam stop is recorded: the target therapeutic dose has been reached. An abnormal termination is determined when one of the following abnormal conditions occurs: The DCCT accumulated power reached 110% of the target power. The actual treatment time reached 120% of the expected treatment time; The instantaneous current monitored by the DCCT exceeded 200% of the predetermined value.

[0046] S400: Calibrates the detector scaling factor and performs grading based on the deviation data.

[0047] In this embodiment, the detector scaling factor is calibrated, and the deviation data is graded. The specific process is as follows: S401: Determine the calibration time and tools, perform calibration before each treatment, use gold foil as the calibration tool, and place the gold foil on the calibration point of the solid water phantom; S402: Perform calibration operation, measure the activation rate of gold foil three times repeatedly, remove outliers and calculate the average activation rate of gold foil; S403: Calculate the detector scaling factor, and combine it with the preset calibration factor and the average activation rate of the gold foil to obtain the calibration scaling factor of the three detectors for the day. S404: Calculate the deviation data, compare the average total count of the three detectors on the current day with the average total count of the previous day, obtain the percentage of count deviation, and process it according to the percentage of deviation.

[0048] Furthermore, in the step of calculating the deviation data, comparing the average total count of the three detectors on the current day with the average total count of the previous day to obtain the percentage of count deviation, and then classifying and processing the data according to the percentage of deviation: When the deviation is less than ±2%, the proportional factor will be issued. When ±2%≤deviation≤±5%, a warning prompt will pop up after the proportional factor is issued, prompting you to check the equipment; If the deviation is ≥ ±5%, the operation will be stopped and maintenance will be requested.

[0049] In the above process, calibration preparation: the calibration time is determined to be before the start of the daily treatment work to avoid the calibration during the treatment process affecting the efficacy; gold foil is selected as the calibration tool. The activation rate of gold foil is stable and it is suitable as a dose calibration benchmark. The gold foil is accurately placed on the preset calibration point of the solid water phantom to simulate the dose monitoring environment during patient treatment.

[0050] Calibration procedure: Start calibration, perform three repeated measurements on the activation rate of the gold foil, remove outliers that significantly deviate from the normal range after measurement, and calculate the average of the three valid measurement results to obtain the average activation rate of the gold foil.

[0051] Scale factor calculation: Combining the preset calibration factor (determined through previous calibration, reflecting the correspondence between gold foil activation rate and neutron dose) and the average activation rate of gold foil calculated this time, the calibration scale factor of the three detectors for the day is calculated respectively, which is used to convert the detector count into the actual dose value.

[0052] Deviation Calculation and Classification: The average total count of the three detectors on the current day is compared with the average total count of the previous day. The percentage difference between the two (i.e., the counting deviation percentage) is calculated, and the deviation is classified and processed according to its magnitude. When the deviation is less than ±2% (the deviation is within the allowable range), the proportional factor calibrated for the day is directly sent to the multiprocessor and industrial control computer, and the system starts treatment normally. When ±2%≤deviation≤±5% (deviation exceeds the slight range), the proportional factor is issued first, and then a warning window pops up (prompting maintenance personnel to check the detector position, shielding integrity, etc.). Only after personnel confirmation can the system enter the treatment ready state. When the deviation is ≥ ±5% (severe deviation that may affect dosage accuracy), immediately stop the treatment operation for the day and indicate: Deviation ≥ ±5%, please perform equipment maintenance; treatment can resume after the maintenance personnel have completed the equipment maintenance (such as replacing the detector, adjusting the shielding structure, etc.) and recalibrated, and the deviation is ≤ ±5%.

[0053] S500: Stores real-time monitoring data and executes retrieval requests to trace the treatment process.

[0054] In this embodiment, real-time monitoring data is stored and retrieval requests are executed to track the treatment process. The specific process is as follows: S501: Determine the data storage range, including real-time neutron count rate, cumulative dose, DCCT current value, treatment time, equipment status data, beam stoppage reason data, daily calibration data, and treatment parameter data during the treatment process; S502: Select storage method, adopting a combination of local storage and server storage. The industrial control computer stores data locally using a cyclic overwrite mechanism, while the server stores data long-term. S503: Establish a data storage architecture to classify and archive local data by timestamp, and store server data in a structured manner according to patient treatment cases and equipment operation cycles; S504: Responding to data retrieval requests, when TCS and maintenance personnel issue data retrieval instructions, after verifying retrieval permissions, it extracts monitoring data for the corresponding time period and treatment case, and generates a traceability report.

[0055] In the above process, the storage scope is determined: the scope of monitoring data to be stored is clearly defined, covering key information throughout the entire treatment process, including: real-time neutron count rate, cumulative dose, DCCT current value (instantaneous value and average value), treatment time (cumulative duration and key node time) during the treatment process, equipment status data (connection status, communication status records), beam stoppage reason data (beam stoppage type, triggering conditions, beam stoppage time), daily calibration data (gold foil activation rate, scaling factor, deviation value), and treatment parameter data (target dose, expected time, etc. issued by TCS).

[0056] Storage method and period selection: A local + server dual-layer storage architecture is adopted. The industrial control computer stores data locally using a cyclic overwrite mechanism (retaining the most recent month's data to meet short-term data retrieval and emergency analysis needs, and avoiding local storage resource overflow); the server adopts a long-term storage mode to permanently retain all data (storage period ≥ 15 years, in compliance with medical data retention requirements).

[0057] Storage architecture establishment: The stored data is managed in a structured manner. Local data is classified and archived according to the timestamp and identifier of "treatment date-treatment time period-patient ID" to facilitate quick location of the treatment data for the current day and the current treatment. Server data is stored in a structured manner according to two dimensions: "patient treatment case" (including patient information, treatment plan, monitoring data, and treatment stop record) and "equipment operation cycle" (including daily calibration data, equipment failure record, and maintenance record), forming a complete data indexing system.

[0058] Data retrieval request response and traceability report generation: When the TCS (Treatment Control System) or maintenance personnel issue a data retrieval command, the system first verifies the retrieval user's permissions (to ensure data security). After the permissions are granted, the system retrieves monitoring data for the corresponding time period and treatment case from the local machine or server according to the retrieval requirements (such as specifying the patient ID, treatment date, and data type). The system automatically integrates the data and generates a standardized traceability report (including data trend charts, key indicator statistics tables, and abnormal event records). The system supports the retrieval user to view and export the report, enabling complete traceability of the treatment process.

[0059] Corresponding to the aforementioned embodiments of the real-time dose monitoring method for a boron neutron capture therapy device, this application also provides embodiments of a real-time dose monitoring system for a boron neutron capture therapy device.

[0060] Figure 7 This is a block diagram illustrating a real-time dose monitoring system for a boron neutron capture therapy apparatus according to an exemplary embodiment. (Refer to...) Figure 7 The system may include: a detection deployment and shielding optimization module 601, a redundant signal acquisition module 602, a beam-stopping logic judgment module 603, a calibration and deviation processing module 604, and a data traceability module 605; wherein: The detection deployment and shielding optimization module 601 is used to divide the main detector and the auxiliary detector, arrange the detector positions, monitor the neutron dose at each position in real time, and configure a multi-layer shielding structure for the detector. The redundant signal acquisition module 602 is used to acquire six redundant signals, including three detector signals, one DCCT signal, one time signal, and one device status signal, and to transmit the redundant signals. The beam stop logic judgment module 603 is used to judge the beam stop situation based on the device connection and communication status, dose and time monitoring data, and obtain beam stop reason data; The calibration and deviation processing module 604 is used to calibrate the detector scaling factor and perform graded processing based on the deviation data. The data traceability module 605 is used to store real-time monitoring data and execute retrieval requests to trace the treatment process.

[0061] In this embodiment, the detection deployment and shielding optimization module 601 divides the detector into a main detector and a secondary detector, arranges the detector positions, monitors the neutron dose at each position in real time, and configures a multi-layer shielding structure for the detector; the redundant signal acquisition module 602 acquires six redundant signals, including three detector signals, one DCCT signal, one time signal, and one device status signal, and transmits the redundant signals; the beam stop logic judgment module 603 judges the beam stop situation based on the device connection and communication status, dose and time monitoring data, and obtains the beam stop reason data; the calibration and deviation processing module 604 calibrates the detector scaling factor and performs graded processing based on the deviation data; the data traceability module 605 stores the real-time monitoring data and executes retrieval requests to trace the treatment process; through the above methods, the reliability and accuracy of real-time dose monitoring in boron neutron capture therapy are improved.

[0062] Regarding the system in the above embodiments, the specific ways in which each module performs operations have been described in detail in the embodiments related to the method, and will not be elaborated here.

[0063] For the system embodiments, since they basically correspond to the method embodiments, the relevant parts can be referred to in the description of the method embodiments. The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed across multiple network units. Some or all of the modules can be selected to achieve the purpose of this application according to actual needs. Those skilled in the art can understand and implement this without creative effort.

[0064] Accordingly, this application also provides an electronic device, comprising: one or more processors; a memory for storing one or more programs; and, when the one or more programs are executed by the one or more processors, causing the one or more processors to implement the real-time dose monitoring method for a boron neutron capture therapy device as described above. Figure 8 The diagram shown is a hardware structure diagram of any device with data processing capabilities, used in a real-time dose monitoring system for a boron neutron capture therapy device according to an embodiment of the present invention. Except for... Figure 8 In addition to the processor, memory, and network interface shown, any data processing device in the embodiment may also include other hardware depending on the actual function of the data processing device, which will not be described in detail here.

[0065] Accordingly, this application also provides a computer-readable storage medium storing computer instructions that, when executed by a processor, implement the real-time dose monitoring method for a boron neutron capture therapy device as described above. The computer-readable storage medium can be an internal storage unit of any data-processing device as described in any of the foregoing embodiments, such as a hard disk or memory. The computer-readable storage medium can also be an external storage device, such as a plug-in hard disk, smart media card (SMC), SD card, flash card, etc., equipped on the device. Furthermore, the computer-readable storage medium can include both internal storage units of any data-processing device and external storage devices. The computer-readable storage medium is used to store the computer program and other programs and data required by the data-processing device, and can also be used to temporarily store data that has been output or will be output.

[0066] Other embodiments of this application will readily occur to those skilled in the art upon consideration of the specification and practice of the disclosure herein. This application is intended to cover any variations, uses, or adaptations of this application that follow the general principles of this application and include common knowledge or customary techniques in the art not disclosed herein.

[0067] It should be understood that this application is not limited to the precise structure described above and shown in the accompanying drawings, and various modifications and changes can be made without departing from its scope.

Claims

1. A method for real-time dose monitoring for a boron neutron capture therapy device, characterized by, The method comprises the following steps: Divide the main detector and the auxiliary detector, arrange the detector positions, monitor the neutron dose of each position in real time, and configure a multi-layer shielding structure for the detector; Collect three-way detector, one-way DCCT, one-way time, and one-way device state, a total of six-way redundant signals, and transmit the redundant signals; Determine the stop beam condition according to the device connection and communication state, dose and time monitoring data, and obtain the stop beam reason data; Calibrate the detector proportion factor, and perform hierarchical processing according to the deviation data; Store the real-time monitoring data, and perform the call request to trace the treatment process.

2. The method for real-time dose monitoring for a boron neutron capture therapy apparatus as claimed in claim 1, wherein, In the step of dividing the main detector and the auxiliary detector, arranging the detector positions, monitoring the neutron dose of each position in real time, and configuring a multi-layer shielding structure for the detector: Two-way He-3 neutron detectors are used as the main detector, and one-way He-3 neutron detector is used as the auxiliary detector; A multi-layer shielding structure is configured for the detector, which comprises, from inside to outside, 1mm-thick cadmium skin with 20% small hole area, 5mm-thick lead skin, and 1cm-thick boron-containing polyethylene containing 50% boron carbide.

3. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 2, wherein, In the step of using two-way He-3 neutron detectors as the main detector and one-way He-3 neutron detector as the auxiliary detector: The main detector is arranged at the neutron beam outlet, and the auxiliary detector is arranged on the proton target backscattering path.

4. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 1, wherein, In the step of collecting three-way detector, one-way DCCT, one-way time, and one-way device state, a total of six-way redundant signals, and transmitting the redundant signals: Determine the six-way redundant signal collection objects; Build a signal collection link to obtain the detector signal, DCCT signal, time signal, and device state signal respectively; Select a transmission medium for the signal; Establish a signal transmission path to transmit the detector signal to the multi-channel processor, and transmit the DCCT signal, time signal, and device state signal to the industrial computer, and simultaneously perform signal interaction between the industrial computer and ACS, TCS, and SIS.

5. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 4, wherein, In the step of determining the six-way redundant signal collection objects: The collection objects are the neutron count rate and cumulative dose signal of the three-way He-3 neutron detector, the accelerator beam instantaneous current and cumulative charge signal of the one-way DCCT, the treatment time signal generated by the industrial computer, and the device state signal for monitoring the connection state of the detector and the multi-channel processor and the external communication link state.

6. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 4, wherein, In the step of selecting a transmission medium for the signal: The detector signal is transmitted through a length>20m radiation-resistant connection cable after preamplification, and the DCCT signal, time signal, and device state signal are transmitted through a CAT6 network cable.

7. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 4, wherein, In the step of determining the stop beam condition according to the device connection and communication state, dose and time monitoring data, and obtaining the stop beam reason data: Check the device connection state, if there is any detector or multi-channel processor without connection, mark the device connection as abnormal; Check the external communication state, if there is any abnormal network communication between the industrial computer and the DCCT, TCS, and SIS, record the communication abnormal information; Receive the treatment parameters issued by the TCS, when the main detector count rate exceeds the set threshold, count the treatment dose through the industrial computer; Determine the stop beam condition according to the monitoring data.

8. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 7, wherein, In the step of judging the shutdown condition according to the monitoring data: When the accumulated dose of the main detector reaches the target dose of 100%, it is determined as normal shutdown; When an abnormal condition occurs, it is determined as abnormal shutdown, and the corresponding shutdown reason data is recorded, wherein the abnormal condition includes that the accumulated electric quantity of the DCCT reaches the target electric quantity of 110%, the treatment time reaches the expected time of 120%, and the instantaneous current of the DCCT exceeds the predetermined value of 200%.

9. The method for real-time dose monitoring of a boron neutron capture therapy apparatus as claimed in claim 1, wherein, In the step of calibrating the detector proportion factor and processing the deviation data: Perform calibration operation, and repeatedly measure the gold foil activation rate three times to calculate the average activation rate of the gold foil after removing abnormal values; Calculate the detector proportion factor, combine the preset calibration factor and the average activation rate of the gold foil, and respectively obtain the calibration proportion factor of the three detectors on the same day; Calculate the deviation data, compare the average total count of the three detectors on the same day with the average total count of the previous day, obtain the count deviation percentage, and process the deviation data according to the deviation percentage.

10. A real-time dose monitoring system for a boron neutron capture therapy device, employing the real-time dose monitoring method for a boron neutron capture therapy device as claimed in claim 1, characterized in that, The system comprises a detection deployment and shielding optimization module, a redundant signal acquisition module, a shutdown logic judgment module, a calibration and deviation processing module, and a data tracing module, wherein: The detection deployment and shielding optimization module is used to divide the main detector and the auxiliary detector, arrange the detector position, monitor the neutron dose of each position in real time, and configure a multi-layer shielding structure for the detector; The redundant signal acquisition module is used to acquire six redundant signals of three detectors, one DCCT, one time and one equipment state, and transmit the redundant signals; The shutdown logic judgment module is used to judge the shutdown condition according to the device connection and communication state, dose and time monitoring data, and obtain the shutdown reason data; The calibration and deviation processing module is used to calibrate the detector proportion factor and process the deviation data; The data tracing module is used to store the real-time monitoring data, execute the call request, and trace the treatment process.

Images