Feed additive and livestock feed

Abstract

The feed additive comprises a methionine hydroxyl analogue and / or a calcium salt thereof, methionine and / or a salt thereof, and guanidinoacetic acid and / or a salt thereof. The livestock feed contains a methionine hydroxy analogue and / or a calcium salt thereof, methionine and / or a salt thereof, guanidinoacetic acid and / or a salt thereof, and a basal feed.

Description

TECHNICAL FIELD

[0001] The present application relates to a feed additive and a feed for livestock, and also relates to a method for raising livestock using the feed for livestock and a method for improving weight gain and feed conversion rate of livestock. BACKGROUND

[0002] Methionine is known as one of essential amino acids that cannot be synthesized in the body of an animal, and is used as a feed additive for livestock and the like.

[0003] Creatine, which is one of amino acids, exists in the body of an animal, and functions as an energy source at the time of exercise. Creatine is produced by methylation of guanidinoacetic acid, which is a precursor thereof. Since guanidinoacetic acid becomes a supply source of creatine, it is proposed to be used as a feed additive (for example, Japanese Patent Application Laid-Open No. 2008-501352 (Patent Document 1)).

[0004] PRIOR ART DOCUMENTS PATENT DOCUMENTS Patent Document 1: Japanese Patent Application Laid-Open No. 2008-501352 SUMMARY

[0005] PROBLEMS TO BE SOLVED BY THE INVENTION For a feed additive and a feed for livestock, it is required to achieve excellent weight gain and feed conversion rate.

[0006] An object of the present application is to provide a feed additive and a feed for livestock, which can improve weight gain and feed conversion rate of livestock.

[0007] MEANS FOR SOLVING THE PROBLEMS The present application provides the following feed additive, feed for livestock, method for raising livestock, and method for improving weight gain and feed conversion rate of livestock.

[0008] (1) A feed additive comprising: a methionine hydroxy analogue and / or a calcium salt thereof, methionine and / or a salt thereof, and guanidinoacetic acid and / or a salt thereof.

[0009] (2) The feed additive according to (1), further comprising a carrier.

[0010] (3) The feed additive according to (2), wherein the carrier comprises a solid carrier, the solid carrier carries the methionine hydroxy analogue.

[0011] (4) A feed for livestock comprising: a methionine hydroxy analogue and / or a calcium salt thereof, methionine and / or a salt thereof, guanidinoacetic acid and / or a salt thereof, and a basal feed.

[0012] (5) The feed for livestock according to (4), further comprising a carrier.

[0013] 〔6〕 The livestock feed according to any one of 〔4〕 to 〔6〕, wherein the carrier comprises a solid carrier. The solid carrier carries the methionine hydroxy analog.

[0014] 〔7〕 A method for raising livestock, comprising a step of causing the livestock to ingest the livestock feed according to any one of 〔4〕 to 〔6〕.

[0015] 〔8〕 The method for raising livestock according to 〔7〕, wherein the livestock is poultry.

[0016] 〔9〕 A method for improving weight gain and feed conversion rate of livestock, comprising a step of causing the livestock to ingest the livestock feed according to any one of 〔4〕 to 〔6〕.

[0017] 〔10〕 The method for improving weight gain and feed conversion rate of livestock according to 〔9〕, wherein the livestock is poultry.

[0018] EFFECT OF THE INVENTION According to the present application, it is possible to provide a feed additive and a livestock feed capable of improving weight gain and feed conversion rate of livestock. DETAILED DESCRIPTION

[0019] (FEED ADDITIVE) The feed additive of the present application (hereinafter sometimes referred to as "the present feed additive") comprises: a methionine hydroxy analog and / or a calcium salt thereof (hereinafter sometimes referred to as "LMA"), methionine and / or a salt thereof (hereinafter sometimes referred to as "DLM"), and guanidino acetic acid and / or a salt thereof (hereinafter sometimes referred to as "GAA").

[0020] The LMA can be a methionine hydroxy analog, can be a calcium salt of a methionine hydroxy analog, or can be a mixture thereof. The methionine hydroxy analog can be a D form, can be an L form, or can be a mixture thereof. The calcium salt of the methionine hydroxy analog can be a D form, can be an L form, or can be a mixture thereof. The LMA is preferably a methionine hydroxy analog.

[0021] The DLM can be methionine, can be a salt of methionine, or can be a mixture thereof. As the salt of methionine, a sodium salt is preferable. The methionine can be L-methionine, can be D-methionine, or can be a mixture thereof. The DLM is preferably L-methionine and / or DL-methionine.

[0022] The GAA can be guanidino acetic acid, can be a salt of guanidino acetic acid, or can be a mixture thereof. As the salt of guanidino acetic acid, a hydrochloride of guanidino acetic acid, a hydrobromide of guanidino acetic acid, and a phosphate of guanidino acetic acid can be mentioned. The GAA is preferably guanidino acetic acid.

[0023] The present feed additive can improve the weight gain and feed conversion ratio (FCR) of livestock by containing LMA, DLM, and GAA. The present feed additive can improve the weight gain and feed conversion ratio of livestock compared to cases where LMA and DLM are used alone, respectively, and cases where one of LMA and DLM is combined with GAA.

[0024] The mass ratio (LMA / DLM) of LMA to DLM contained in the present feed additive can be 0.05 or more, can be 0.1 or more, can be 0.3 or more, or can be 0.5 or more. The LMA / DLM can be 10.0 or less, can be 5.0 or less, can be 3.0 or less, or can be 2.0 or less. The LMA / DLM can be 0.05 or more and 10.0 or less, can be 0.1 or more and 5.0 or less, can be 0.3 or more and 3.0 or less, or can be 0.5 or more and 2.0 or less. In the present specification, in the case where LMA contains two or more of the above components, the mass of LMA refers to the total amount thereof. In the present specification, in the case where DLM contains two or more of the above components, the mass of DLM refers to the total amount thereof.

[0025] The content of GAA in the present feed additive can be 5% by mass or more, can be 10% by mass or more, can be 15% by mass or more, or can be 18% by mass or more, of the total amount of LMA and DLM. The content of GAA in the present feed additive can be 50% by mass or less, can be 40% by mass or less, can be 30% by mass or less, or can be 25% by mass or less, of the total amount of LMA and DLM. The content of GAA in the present feed additive can be 5% by mass or more and 50% by mass or less, can be 10% by mass or more and 40% by mass or less, can be 15% by mass or more and 40% by mass or less, can be 15% by mass or more and 30% by mass or less, can be 15% by mass or more and 25% by mass or less, can be 18% by mass or more and 30% by mass or less, or can be 18% by mass or more and 25% by mass or less, of the total amount of LMA and DLM.

[0026] The content of LMA in the present feed additive (hereinafter sometimes referred to as "the content of LMA in the present feed additive") can be 5% by mass or more, can be 10% by mass or more, can be 15% by mass or more, can be 20% by mass or more, can be 25% by mass or more, can be 30% by mass or more, or can be 35% by mass or more, when the total amount of LMA, DLM, and GAA in the present feed additive is set to 100% by mass. The content of LMA in the present feed additive can be 75% by mass or less, can be 55% by mass or less, or can be 45% by mass or less. The content of LMA in the present feed additive can be 5% by mass or more and 75% by mass or less, can be 10% by mass or more and 55% by mass or less, can be 15% by mass or more and 45% by mass or less, can be 20% by mass or more and 45% by mass or less, can be 25% by mass or more and 45% by mass or less, can be 30% by mass or more and 45% by mass or less, or can be 35% by mass or more and 45% by mass or less.

[0027] The content of DLM in the present feed additive (hereinafter sometimes referred to as "the content of DLM in the present feed additive") can be 5% by mass or more, can be 10% by mass or more, can be 15% by mass or more, can be 20% by mass or more, can be 25% by mass or more, can be 30% by mass or more, or can be 35% by mass or more, when the total amount of LMA, DLM, and GAA in the present feed additive is set to 100% by mass. The content of DLM in the present feed additive can be 75% by mass or less, can be 55% by mass or less, or can be 45% by mass or less. The content of DLM in the present feed additive can be 5% by mass or more and 75% by mass or less, can be 10% by mass or more and 55% by mass or less, can be 15% by mass or more and 45% by mass or less, can be 20% by mass or more and 45% by mass or less, can be 25% by mass or more and 45% by mass or less, can be 30% by mass or more and 45% by mass or less, or can be 35% by mass or more and 45% by mass or less.

[0028] The content of GAA in the present feed additive (hereinafter sometimes referred to as "the content of GAA in the present feed additive") can be 5% by mass or more, can be 10% by mass or more, or can be 15% by mass or more, when the total amount of LMA, DLM, and GAA in the present feed additive is set to 100% by mass. The content of GAA in the present feed additive can be 45% by mass or less, can be 35% by mass or less, or can be 25% by mass or less. The content of GAA in the present feed additive can be 5% by mass or more and 45% by mass or less, can be 10% by mass or more and 35% by mass or less, or can be 15% by mass or more and 25% by mass or less.

[0029] The total amount of LMA, DLM, and GAA in the present feed additive can be 15% by mass or more, 20% by mass or more, 30% by mass or more, 50% by mass or more, 80% by mass or more, 90% by mass or more, or 95% by mass or more. The total amount of LMA, DLM, and GAA in the present feed additive can be 100% by mass or less, 95% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, or 40% by mass or less. The total amount of LMA, DLM, and GAA in the present feed additive can be 15% by mass or more and 100% by mass or less, 20% by mass or more and 90% by mass or less, 30% by mass or more and 80% by mass or less, 50% by mass or more and 70% by mass or less, 20% by mass or more and 100% by mass or less, 80% by mass or more and 100% by mass or less, 90% by mass or more and 100% by mass or less, 95% by mass or more and 100% by mass or less, 50% by mass or more and 95% by mass or less, 50% by mass or more and 60% by mass or less, 20% by mass or more and 40% by mass or less, 30% by mass or more and 50% by mass or less, or 30% by mass or more and 40% by mass or less.

[0030] The present feed additive can further include a carrier. The carrier included in the present feed additive can be a carrier in which the present feed additive is formulated into a powder or a granule, or the like, or a carrier in which LMA, DLM, and / or GAA is formulated. As the carrier, excipient substances used in the art can be mentioned. As the solid carrier, for example, lactose, sucrose, glucose, dextrin, corn starch, corn flour, gelatin, casein, starch, gum arabic, cellulose derivatives such as ethyl cellulose, alginic acid, rice husk, diatomaceous earth, anhydrous silicic acid, anhydrous silicate, light anhydrous silicic acid, silicic acid, silicate, hydrous silicon dioxide, hydrous amorphous silicon oxide, talc, vermiculite, kaolin, perlite, bentonite, zeolite, calcium carbonate, and the like can be mentioned.

[0031] In the case where the LMA included in the present feed additive includes a methionine hydroxy analog, the present feed additive preferably includes a solid carrier. By supporting the methionine hydroxy analog with the solid carrier, it is possible to solidify the methionine hydroxy analog. Thereby, it is possible to improve the handleability.

[0032] In the case where the methionine hydroxy analog is supported on a carrier, the carrier is preferably an inorganic carrier. The particle diameter of the carrier is preferably 1 μm or more and 2000 μm or less, more preferably 5 μm or more and 1000 μm or less, more preferably 10 μm or more and 850 μm or less, further preferably 50 μm or more and 710 μm or less, and still further preferably 100 μm or more and 500 μm or less, of an inorganic carrier. The carrier is preferably one or more selected from the group consisting of diatomaceous earth, anhydrous silicic acid, anhydrous silicate, light anhydrous silicic acid, silicic acid, silicate, hydrous silicon dioxide, hydrous amorphous silicon oxide, zeolite, and perlite, and more preferably zeolite. As the zeolite, MINE ZEON (Nittetsu Mining Co., Ltd.) or the like can be used. In the present specification, the particle diameter refers to the mode diameter of the mass-based particle size distribution obtained by the sieving method.

[0033] In the preparation of the present feed additive, in the case where spray drying is performed, the carrier can be an organic carrier or an inorganic carrier. As the organic carrier, sugars such as lactose, starches (including starch decompositions), dextrin, cyclodextrin, sucrose, maltose, glucose, ethyl cellulose, gum arabic, xanthan gum, guar gum, and tragacanth gum; sugar alcohols such as maltitol, erythritol, xylitol, sorbitol, mannitol, lactitol, trehalose, and reduced palatinose; and corn starch can be exemplified. As the inorganic carrier, sodium chloride, anhydrous silicic acid, anhydrous silicate, light anhydrous silicic acid, silicic acid, silicate, hydrous silicon dioxide, hydrous amorphous silicon oxide, calcium sulfate, calcium hydrogen phosphate, and the like can be exemplified. One or more selected from the group consisting of lactose, dextrin, ethyl cellulose, and corn starch is preferred as the organic carrier, and dextrin is further preferred. They can be used individually or in combination. The sugar alcohol can be any of anhydrous and hydrate. In the case where the present feed additive is prepared by spray drying, the carrier can not be used.

[0034] In the case where the methionine hydroxy analog is supported on a carrier, the content of the carrier in the present feed additive can be 5% by mass or more, can be 10% by mass or more, can be 15% by mass or more, can be 50% by mass or less, can be 45% by mass or less, or can be 40% by mass or less. In the case where the methionine hydroxy analog is supported on a carrier, the content of the carrier in the present feed additive can be 5% by mass or more and 50% by mass or less, can be 10% by mass or more and 45% by mass or less, or can be 15% by mass or more and 40% by mass or less.

[0035] In the case where the present feed additive is produced by spray drying, the present feed additive can or can not contain a carrier. In the case where the present feed additive contains a carrier, the content of the carrier in the suspension used for producing the present feed additive by spray drying can be 5% by mass or less, can be 3% by mass or less, can be 2% by mass or less, or can be 1% by mass or less.

[0036] The present feed additive can contain one or more of other components such as proteins, vitamins (vitamin A, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, vitamin D, vitamin E, calcium pantothenate, nicotinamide, folic acid, and the like), and trace inorganic salts (magnesium sulfate, iron sulfate, copper sulfate, zinc sulfate, potassium iodide, cobalt sulfate, and the like). The present feed additive can contain one or more of additives such as antioxidants, antibacterial agents, antifungal agents, insect repellents, fragrances, pigments, taste-imparting agents, and enzymes.

[0037] The present feed additive can be produced by mixing LMA, DLM, and GAA. The mixing of LMA, DLM, and GAA can be performed by putting all of these three components into a mixing container, or can be performed by first mixing two of these three components to obtain a mixture, and then mixing the remaining one with the mixture. In the case where the present feed additive contains a carrier, other components, and / or additives, they can be mixed at an appropriate timing. For example, the carrier can be mixed with a mixture of components other than the carrier contained in the present feed additive, or a specific component contained in the present feed additive can be mixed with the carrier, and then the remaining components can be mixed with them.

[0038] In the case where the LMA contains the methionine hydroxy analog, it is preferable to solidify the methionine hydroxy analog by supporting it on a solid carrier. In this case, the present feed additive can be produced by mixing the solidified methionine hydroxy analog with the remaining ingredients contained in the present feed additive. As described above, the methionine hydroxy analog can improve the workability by solidification, and thus is easily mixed uniformly with the DLM and the GAA. In the case where the present feed additive containing the LMA, the DLM, the GAA, and the carrier is prepared by mixing the methionine hydroxy analog, the DLM, and the GAA, which have been solidified in advance, the method and the apparatus are not particularly limited, and techniques known in the technical field to which the present application pertains can be utilized. As the method, a method of producing by pulverizing, mixing, granulating, or the like can be generally mentioned. As the apparatus, a roll mill, a jet mill, a hammer mill, a pin mill, a W-type mixer, a V-type mixer, a drum-type mixer, a belt-type mixer, a blade-type mixer, a screw cone-type mixer, a fluidized bed granulation dryer, a stirring granulation dryer, or the like is widely used. From the viewpoint of supporting the methionine hydroxy analog, the particle diameter of the carrier can be 10 μm or more and 2000 μm or less, can be 50 μm or more and 1000 μm or less, can be 100 μm or more and 850 μm or less, can be 150 μm or more and 710 μm or less, can be 180 μm or more and 600 μm or less, or can be 210 μm or more and 500 μm or less. From the viewpoint of easily mixing uniformly with the methionine hydroxy analog supported on the carrier, the particle diameter of each of the DLM and the GAA can be 5 μm or more and 1000 μm or less, can be 50 μm or more and 810 μm or less, can be 100 μm or more and 850 μm or less, can be 150 μm or more and 710 μm or less, can be 180 μm or more and 600 μm or less, or can be 210 μm or more and 500 μm or less.

[0039] In the case where the methionine hydroxy analog is supported on the carrier, the mass ratio (carrier / methionine hydroxy analog) can be, for example, 0.1 or more and 30.0 or less, can be 0.5 or more and 20.0 or less, can be 1.0 or more and 15.0 or less, can be 2.0 or more and 10.0 or less, or can be 2.0 or more and 5.0 or less.

[0040] In the case where the present feed additive containing the carrier is produced by spray drying, the DLM, the GAA, and the carrier are pulverized and mixed, and after being sufficiently homogenized, the LMA diluted with a solvent such as water is added, and a suspension containing the DLM, the GAA, the LMA, and the carrier is produced while being warmed. The suspension is subjected to spray drying while being warmed and stirred, and thus the present feed additive containing the carrier can be obtained.

[0041] The feed additive of the present application can be ingested by livestock directly or as livestock feed obtained by mixing the feed additive with a basal feed for livestock as described later. The amount ingested by the livestock is set in a manner to satisfy the methionine requirement of the livestock. The feed additive of the present application can be ingested during the entire feeding period of the livestock or during a specific period of the feeding period.

[0042] As the livestock ingesting the feed additive of the present application, there can be mentioned poultry such as chickens (broilers, layers), ducks, quails, domestic ducks, geese, pigeons, turkeys, and ostriches; mammals such as cattle, goats, horses, camels, water buffalos, pigs, and sheep; and the like. The livestock is preferably poultry, and more preferably chickens.

[0043] (Livestock feed) The livestock feed of the present application (hereinafter sometimes referred to as "the present livestock feed") contains LMA, DLM, GAA, and a basal feed. That is, the present livestock feed can contain the feed additive of the present application and the basal feed. The livestock feed can further contain a carrier. Details of the components contained in the present livestock feed and the feed additive of the present application such as LMA, DLM, GAA, and the carrier are as described above.

[0044] The basal feed is a feed composition that can be combined with the feed additive of the present application, and is not particularly limited as long as it is a substance generally used as a livestock feed. As the feed raw material contained in the basal feed, there can be mentioned corn, rice, wheat (barley, wheat), milo, grain sorghum, soybean meal, rapeseed meal, bran, defatted rice bran, fish meal, defatted milk powder, dried whey, alfalfa powder, north fish meal, soybean oil, palm oil, coconut oil, rapeseed oil, safflower oil, corn oil, cottonseed oil, animal fat (meat meal, chicken meal, lard, tallow, etc.), wheat flour, meat and bone meal (feather meal), calcium phosphate, corn gluten meal, corn distillers grain soluble, corn germ meal, molasses, calcium carbonate, tricalcium phosphate, sodium chloride, choline chloride, vitamins (vitamin A, vitamin Bl, vitamin B2, vitamin B6, vitamin B12, vitamin D, vitamin E, calcium pantothenate, nicotinamide, folic acid, etc.), amino acids other than LMA and DLM (lysine, threonine, etc.), trace inorganic salts (magnesium sulfate, iron sulfate, copper sulfate, zinc sulfate, potassium iodide, cobalt sulfate, selenium compounds, etc.), organic acids (formic acid, fumaric acid, propionic acid, butyric acid, etc.), enzymes (phytase, etc.), live bacteria agents, prebiotics, inactivated bacteria agents, and the like.

[0045] The present livestock feed contains LMA, DLM, and GAA, and thus can improve the weight gain and feed conversion rate of the livestock. As the livestock ingesting the present livestock feed, there can be mentioned the above-mentioned livestock.

[0046] The content of LMA, DLM and GAA in the present livestock feed is set in a manner to satisfy the methionine requirement of the livestock based on the ingredient composition of the basal feed. The basal feed is usually adjusted in the ingredient composition according to the growth stage of the livestock, and thus the content of LMA, DLM and GAA (or the present feed additive) is adjusted according to the ingredient composition of the basal feed to which they are compounded.

[0047] For example, the content of LMA in the present livestock feed can be 0.01 mass% or more and 3.00 mass% or less, 0.02 mass% or more and 2.50 mass% or less, 0.03 mass% or more and 2.00 mass% or less, or 0.05 mass% or more and 1.00 mass% or less. For example, the content of DLM in the present livestock feed can be 0.01 mass% or more and 4.00 mass% or less, 0.03 mass% or more and 3.00 mass% or less, 0.05 mass% or more and 2.00 mass% or less, or 0.10 mass% or more and 1.00 mass% or less. For example, the content of GAA in the present livestock feed can be 0.01 mass% or more and 2.00 mass% or less, 0.01 mass% or more and 1.50 mass% or less, 0.02 mass% or more and 1.00 mass% or less, or 0.03 mass% or more and 0.50 mass% or less.

[0048] The mass ratio of LMA to DLM (LMA / DLM) in the present livestock feed can be 0.05 or more, 0.1 or more, 0.3 or more, or 0.5 or more. The LMA / DLM can be 10.0 or less, 5.0 or less, 3.0 or less, or 2.0 or less. The LMA / DLM can be 0.05 or more and 10.0 or less, 0.1 or more and 5.0 or less, 0.3 or more and 3.0 or less, or 0.5 or more and 2.0 or less.

[0049] The content of GAA in the present livestock feed can be 5% by mass or more, 10% by mass or more, 15% by mass or more, or 18% by mass or more of the total amount of LMA and DLM. The content of GAA in the present livestock feed can be 50% by mass or less, 40% by mass or less, or 30% by mass or less of the total amount of LMA and DLM. The content of GAA in the present livestock feed can be 5% by mass or more and 50% by mass or less, 10% by mass or more and 40% by mass or less, 15% by mass or more and 40% by mass or less, 15% by mass or more and 30% by mass or less, 15% by mass or more and 25% by mass or less, 18% by mass or more and 30% by mass or less, or 18% by mass or more and 25% by mass or less of the total amount of LMA and DLM.

[0050] The present livestock feed can be produced by mixing LMA, DLM, GAA, and a base feed, can be produced by mixing the present feed additive and a base feed, or can be produced by mixing LMA, DLM, GAA, and a feed raw material that constitutes a base feed. The mixing of LMA, DLM, GAA, and a base feed (or a feed raw material) can be performed by all of them being put into a mixing container, or can be performed by each component being sequentially put into a mixing container and mixed. In the case where the present livestock feed contains methionine hydroxy analog, methionine hydroxy analog that is solidated by being supported on a solid carrier can also be mixed with the remaining components contained in the present livestock feed.

[0051] The present livestock feed can be ingested by livestock. The present livestock feed can be used in a method for raising livestock and / or a method for improving weight gain and feed conversion rate of livestock. The method for raising livestock and the method for improving weight gain and feed conversion rate of livestock each include a step of causing livestock to ingest the present livestock feed. The present livestock feed can be used for improving weight gain and feed conversion rate of livestock.

[0052] The amount of the present livestock feed ingested by livestock can be set so as to satisfy the methionine requirement amount of the livestock. The present livestock feed can be ingested throughout the entire feeding period of the livestock, or can be ingested during a specific period of the feeding period. In the case where the livestock is poultry, it is preferable that the present livestock feed be ingested throughout the entire feeding period of the poultry.

[0053] Examples Hereinafter, the present application will be described in further detail by way of examples and comparative examples, but the present application is not limited by these examples.

[0054] The raw materials used in Test Example 1 and Test Example 2 are as follows.

[0055] DLM: DL-methionine (purity: 99%) LMA: DL form of methionine hydroxy analog (purity: 88%) GAA: guanidino acetic acid (purity: 96%) Diatomaceous earth: RADIOLITE #200, Showa Chemical Industry Co., Ltd. Zeolite: MINE ZEON #7, Nitto Funka Co., Ltd. Perlite: Topco 5B, Showa Chemical Industry Co., Ltd. Hydrated silica: CARPLEX XR, Evonik Industries [Experiment Example 1] [Preparation of basal feed] As shown in Table 1, basal feeds (1) to (3) to which raw materials were compounded were prepared.

[0056] [Table 1] Metabolic energy and contents of each component calculated from the composition of the basal feeds (1) to (3) are shown in Table 2 (values calculated based on Japanese Standard Feed Composition Table (2009 edition)). In Table 2, the satisfaction rate with respect to the requirement amount of broiler chickens for the calculated metabolic energy and contents of each component (Ross Nutrition Specification 2019) is also shown.

[0057] [Table 2] [Preparation of feed additive] The DLM, LMA, and GAA were mixed so as to be in the proportions shown in (1-6), (2-6), and (3-6) of Table 3 to prepare the present feed additive.

[0058] [Preparation of livestock feed] The present feed additive obtained above and the basal feeds (1) to (3) were mixed so as to be in the proportions shown in (1-6), (2-6), and (3-6) of Table 3 to prepare the livestock feed. The other livestock feeds of Table 3 were prepared by mixing the DLM, LMA, GAA, and the basal feeds (1) to (3) so as to be in the proportions shown in Table 3. The total content of the DLM and LMA in the livestock feed was set so as to be 98% of the requirement amount of the total amount of methionine and cystine for broiler chickens (column of “digestible methionine + cystine” in Table 2).

[0059] For example, 997.2 kg of the base feed (1) is weighed and put into a tank of a ribbon mixer (RM-300, manufactured by Shizuoka Seiko Co., Ltd.), and DLM 2.8 kg is added while mixing at a prescribed rotation speed, and further mixed for 10 minutes to obtain 1,000 kg of the livestock feed (1-1). Other livestock feeds are also mixed in the same manner to obtain the required amount.

[0060] [Table 3] (Test animals) Male broiler chickens were used in the test. 16 broiler chickens were allocated per 1 group (replication), and the number of replications in each test area was set to 7.

[0061] (Test period) The period from 0 days of age to 42 days of age of the broiler chickens was set as the test period.

[0062] (Test area) Six test areas shown in Table 4 were set. The test period was divided into an early period of 0 days of age to 7 days of age, a middle period of 8 days of age to 21 days of age, and a late period of 22 days of age to 42 days of age, and the broiler chickens were made to ingest the livestock feeds shown in Table 4 in each period.

[0063] [Table 4] (Evaluation) After the end of the test, the average values of the weight gain (the amount of weight increase during the test period = the weight at the end of the test - the weight before the start of the test) of the broiler chickens in each test area, and the feed conversion rate (= the amount of feed intake during the test period / the weight gain during the test period) were calculated. The results are shown in Table 5.

[0064] [Table 5] As described above, in the case of the test area 6 in which the broiler chickens were made to ingest the livestock feed containing LMA, DLM, and GAA in addition to the base feed, the weight gain and the feed conversion rate were improved compared to the other test areas 1 to 5.

[0065] [Test Example 2] (Preparation of base feed) The base feeds (4) to (6) in which the raw materials were blended were prepared as shown in Table 6.

[0066] [Table 6] The metabolic energy and the content of each component calculated from the composition of the basal feed (4) to (6) are shown in Table 7 (values calculated based on the Japanese Standard Feed Ingredient Table (2009 edition)). The satisfaction rate with respect to the required amount for broiler chickens is also shown in Table 7 (Ross Nutrition Specification 2019) for the calculated metabolic energy and the content of each component.

[0067] [Table 7] [Preparation of feed additive] A feed additive was obtained using DLM, LMA, GAA, and a carrier in the proportions shown in Table 8. Specifically, in the case of preparing the present feed additive for manufacturing 1,000 kg of livestock feed (4-1), 4.8 kg of diatomaceous earth was added to the container of a universal mixing blender "30DM-rr", and 1.7 kg of LMA was added little by little to the container while stirring at 68 rpm, and the LMA was allowed to be sufficiently impregnated in the diatomaceous earth by stirring for 5 minutes, and the state of impregnation was confirmed. Next, 1.5 kg of DLM and 0.6 kg of GAA were added to the container, and further stirring was performed for 5 minutes, and a total of 8.6 kg of the present feed additive was obtained. The present feed additive mixed in the livestock feeds (4-2) to (6-3) was also obtained by the same operation.

[0068] [Preparation of livestock feed] The above-obtained present feed additive and the basal feed (4) to (6) were mixed in the proportions shown in Table 8 to prepare the livestock feed. The total content of DLM and LMA in the livestock feed was set so as to be 98 to 100% of the required amount of the total amount of methionine and cystine for broiler chickens (column of "digestible methionine + cystine" in Table 7). For example, in the case where 1,000 kg of livestock feed (4-1) was required, 991.4 kg of the basal feed (4) was weighed, and the above-obtained feed additive 8.6 kg was added to the tank of a belt-type mixer (RM-300, manufactured by NIDEC Corporation) while mixing at a predetermined rotation speed, and further mixing was performed for 10 minutes, and 1,000 kg of the livestock feed (4-1) was obtained. The other livestock feeds were also mixed by the same operation to obtain the required amount.

[0069] [Table 8] (Test animals) Male broiler chickens were used in the test. Ten broiler chickens were allocated per 1 group (replicate), and the number of replicates in each test area was set to 4.

[0070] (Test period) The period from 0 days of age to 42 days of age of the broiler chickens was set as the test period.

[0071] (Test Area) Three test areas shown in Table 9 were set. The test period was divided into a pre-stage of 0 days of age to 7 days of age, a middle stage of 8 days of age to 21 days of age, and a post-stage of 22 days of age to 42 days of age, and the broiler chickens were caused to ingest the livestock feed shown in Table 9 in each stage.

[0072] [Table 9] (Evaluation) After the end of the test, the average of the weight gain (the increase in body weight during the test period = the body weight at the end of the test - the body weight before the start of the test) of the broiler chickens and the feed conversion rate (= the amount of feed intake during the test period / the weight gain during the test period) in each test area was calculated. The results are shown in Table 10.

[0073] [Table 10] As shown in Table 10, the test area 8 in which the zeolite was used became the best result.

[0074] In addition to the above, the feed additive can also be prepared with the composition described in Table 11 and Table 12. The obtained feed additive is mixed into the livestock feed and administered to the livestock as with the above, whereby the weight gain and the feed conversion rate can be improved.

[0075] [Table 11] [Table 12]

Claims

1. A feed additive comprising: a methionine hydroxy analog and / or a calcium salt thereof, methionine and / or a salt thereof, and guanidino acetic acid and / or a salt thereof.

2. The feed additive according to claim 1, further comprising a carrier.

3. The feed supplement of claim 2, wherein, the carrier comprises a solid carrier, the solid carrier carries the methionine hydroxy analog.

4. A feed for livestock comprising: a methionine hydroxy analog and / or a calcium salt thereof, methionine and / or a salt thereof, guanidino acetic acid and / or a salt thereof, and a basal feed.

5. The feed for livestock according to claim 4, further comprising a carrier.

6. The feed for domestic animals as claimed in claim 5, wherein, the carrier comprises a solid carrier, the solid carrier carries the methionine hydroxy analog.

7. A method for rearing livestock, comprising a step of causing the livestock to ingest the feed for livestock according to any one of claims 4 to 6.

8. The rearing method of claim 7, wherein, the livestock is poultry.

9. A method for improving weight gain and feed conversion rate of livestock, comprising a step of causing the livestock to ingest the feed for livestock according to any one of claims 4 to 6.

10. The method of claim 9, wherein, the livestock is poultry.

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