Preparation process of traditional Chinese medicine compound nanoemulsion

Traditional Chinese medicine compound nanoemulsions were prepared by supercritical CO2 extraction and high-pressure homogenization, which solved the problems of stability and large-scale production of traditional Chinese medicine nanoemulsions, and achieved efficient drug delivery and antibacterial effects, making them suitable for large-scale production.

CN121360166APending Publication Date: 2026-01-20BOZHOU VOCATIONAL & TECHNICAL COLLEGE +1
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Patent Information

Application Number
CN202511823912.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-05
Publication Date
2026-01-20

AI Technical Summary

Technical Problem

Traditional Chinese medicine nanoemulsions face challenges in terms of stability and large-scale production, and their high production costs make them difficult to promote.

Method used

Traditional Chinese medicine components were extracted using a combination of supercritical CO2 extraction with anhydrous ethanol and water decoction. Nanoemulsions were prepared using a high-pressure circulating homogenization method. Isopropyl myristate and poloxamer were selected as the oil phase and emulsifier, respectively, to prepare a traditional Chinese medicine compound nanoemulsion with high stability and low organic solvent residue.

Benefits of technology

It improves the solubility and bioavailability of active ingredients in traditional Chinese medicine, enhances targeting and sustained release, reduces the minimum inhibitory concentration, enhances the antibacterial effect against a variety of pathogens, achieves stability and safety, and is suitable for large-scale production.

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Abstract

The invention discloses a preparation process of a traditional Chinese medicine compound nanoemulsion. The preparation process is characterized by comprising the following steps: S1, weighing the following components in parts by weight: 10-20 parts of chrysanthemum, 10-20 parts of honeysuckle, 10-20 parts of cortex pseudolaricis, 10-20 parts of radix sophorae flavescentis, 10-15 parts of dandelion, 10-15 parts of herba violae, 10-20 parts of wild chrysanthemum flower and 10-15 parts of radix semiaquilegiae; s2, crushing and extracting, namely extracting by adopting a double extraction method, namely firstly extracting by using supercritical CO2 and an entrainer absolute ethyl alcohol, then extracting decoction dregs after extraction once by using a water decoction method, and finally combining with an extracting solution; s3, concentration: according to the mass percentage, concentrating the extracting solution through a vacuum concentration method until each milliliter of the extracting solution is equivalent to 0.5%-2.0% of the raw medicinal materials; s4, preparing nano-emulsion: adding an oil phase, an emulsifier, a co-emulsifier and a water phase into the concentrated solution, performing high-pressure circulating homogenization to obtain oil-in-water type nano-emulsion, and preparing the nano-emulsion by adopting a high-pressure homogenization method. The nanoemulsion is wide in antibacterial spectrum, few in organic solvent residue and high in stability.
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