Essential oil formula containing rose geranium and complete cananga odorata for improving hormone secretion

Abstract

The invention provides an essential oil formula containing rose geranium and complete cananga odorata for improving hormone secretion, and belongs to the technical field of daily chemical industry and biological health care. According to the formula, a three-layer system is formed by core effect essential oil, composite base oil and functional auxiliary materials, wherein the core effect essential oil is formed by compounding 1.2%-1.8% of rose geranium essential oil, 2.0%-3.0% of complete cananga odorata essential oil and 0.6%-1.0% of Damascus rose essential oil, and an estrogen receptor is synergistically activated according to the proportion of 1: 1.5-1: 2.0; the composite base oil is a mixture of jojoba oil, sweet almond oil and evening primrose oil, and 0.1-0.3% of vitamin E is supplemented to improve the stability; massage essential oil or aromatherapy essential oil can be prepared through the processes of specific CO2 supercritical extraction of raw materials, nitrogen protection stirring, vacuum degassing and the like. The activity of the core essential oil is improved by 15%-30%, the skin permeability reaches 25%-30% within 30 minutes, the flower fragrance persistence is larger than or equal to 8 hours, the stability is excellent after the essential oil is stored at 40 DEG C for 6 months, premenstrual tension and climacteric hectic fever of women can be effectively relieved, the skin irritation rate is 0, and the essential oil has efficacy, sense and safety.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical and bio-health technology, and more specifically, it relates to an essential oil formula containing rose geranium and ylang-ylang to improve hormone secretion. Background Technology

[0002] Hormonal imbalance is a common health problem among women, especially during the premenstrual and menopausal periods, when estrogen fluctuations can trigger symptoms such as breast tenderness, hot flashes, night sweats, and anxiety, severely impacting their quality of life. With the increasing popularity of natural skincare concepts, essential oils have become a research hotspot in this field due to their potential to gently regulate the endocrine system. However, existing essential oil products for regulating hormones still have significant technical shortcomings: Limited efficacy of single essential oils: When using rose geranium essential oil alone, the activation rate of estrogen receptors is only about 32%, and the regulatory activity is weak; although the activity of pure ylang-ylang essential oil is slightly higher (about 35%), it is easy to produce a pungent odor due to the high proportion of benzyl acetate (18%~22%), which is difficult to meet the sensory needs of daily use. The fragrance and efficacy are difficult to coordinate: In order to pursue the effect of hormone regulation, most functional essential oils will increase the proportion of single-effect essential oils, resulting in a chaotic fragrance (for example, essential oils containing only pure ylang-ylang have a sensory score of less than 6 points); some products add artificial fragrances (such as coumarin and muscone) to improve the fragrance, but fragrance ingredients are prone to causing skin irritation such as redness and itching, and the pass rate of human patch tests is only 70% to 80%. Low skin absorption efficiency: Most existing products use a single base oil (such as pure sweet almond oil or pure jojoba oil), and the core essential oils rely on passive absorption through the skin for transdermal penetration. The penetration rate is generally less than 15% after 30 minutes, which means that the effective ingredients cannot fully act on the hypothalamus-pituitary-gonadal axis, and the actual regulatory effect is reduced (such as the menopausal hot flash relief rate of only 25%~30%). Poor storage stability: Essential oils contain a large amount of unsaturated terpenoids (such as geraniol and linalool), which are easily oxidized and deteriorated by oxygen. Existing essential oil products without excipients lose more than 30% of their active ingredients, increase acid value by more than 0.5 mg KOH / g, and exceed 5.0 meq / kg after 3 months of storage at 40℃ and 75% relative humidity, which cannot meet the shelf life requirement of more than 12 months. To address the shortcomings of existing technologies, there is an urgent need to develop a compound essential oil formula that can achieve "synergistic enhancement of efficacy, natural and long-lasting floral fragrance, efficient skin absorption, and stable and safe storage" to fill the market gap. Summary of the Invention

[0003] To address the aforementioned technical problems, this invention provides an essential oil formula containing rose geranium and pure ylang-ylang to improve hormone secretion. This formula solves the technical problems of existing hormone-regulating essential oil products, such as the limitations of single essential oil efficacy (weak activity or pungent aroma), difficulty in synergizing floral fragrance and efficacy (chaotic aroma or artificial fragrance that irritates the skin), low skin absorption efficiency (low penetration rate of single base oil), poor storage stability (easy to oxidize and deteriorate, short shelf life), and insufficient adaptability to application scenarios.

[0004] An essential oil formula containing rose geranium and whole ylang-ylang to improve hormone secretion, comprising, by weight percentage, the core active essential oil and the base oil; The core functional essential oil is composed of 1.2%–1.8% rose geranium essential oil, 2.0%–3.0% pure ylang-ylang essential oil, and 0.6%–1.0% Damask rose essential oil, with the remainder being base oil; Rose geranium essential oil contains 35%–40% citronellol and 15%–20% geraniol, while ylang-ylang essential oil contains 25%–30% linalool and 18%–22% benzyl acetate. The two work synergistically to activate the endocrine regulatory pathway in the human body.

[0005] Preferably, by weight percentage, the core active essential oils are 1.5% rose geranium essential oil, 2.5% pure ylang-ylang essential oil, and 0.8% Damask rose essential oil.

[0006] Preferably, the base oil is selected from at least two of jojoba oil, sweet almond oil, and evening primrose oil, wherein jojoba oil accounts for 20% to 30% of the total base oil (containing 3% to 5% phytosterols to enhance the antioxidant properties of the formulation), sweet almond oil accounts for 40% to 50% of the total base oil (containing 75% to 80% unsaturated fatty acids to enhance skin compatibility), and evening primrose oil accounts for 20% to 30% of the total base oil (containing 8% to 10% γ-linolenic acid to assist in regulating prostaglandin synthesis).

[0007] Preferably, the rose geranium essential oil, ylang-ylang essential oil, and damask rose essential oil are all prepared using supercritical carbon dioxide extraction technology. The specific process parameters are: extraction pressure 30-40 MPa, extraction temperature 40-50℃, CO2 flow rate 20-30 L / h, separation pressure 8-10 MPa, and separation temperature 30-35℃. The essential oils prepared by this process have a purity of ≥98%, a volatile impurity content of ≤0.5%, and a retention rate of effective components that is 25% to 30% higher than that prepared by steam distillation.

[0008] Preferably, during preparation, the core functional essential oil is first placed in a sterile mixing tank and mixed at a speed of 200-300 r / min for 10-15 minutes (to ensure uniform dispersion of components and a coefficient of variation ≤5%). Then, the base oil preheated to 20-25°C is added, and the speed is adjusted to 100-150 r / min and mixing is continued for 20-30 minutes. After mixing, the mixture is allowed to stand for 1-2 hours to remove air bubbles. The entire preparation process is carried out under nitrogen protection to prevent the essential oils from oxidizing and deteriorating.

[0009] Preferably, the weight ratio of rose geranium essential oil to ylang-ylang essential oil is 1:1.5 to 1:2.0; when the ratio is 1:1.8, the regulatory activity of both on hypothalamic gonadotropin-releasing hormone (GnRH) reaches its peak.

[0010] Preferably, the floral fragrance intensity of the formula is detected by gas chromatography-mass spectrometry, wherein the total content of linalool and geraniol acetate is not less than 35% of the total amount of the core functional essential oil.

[0011] Preferably, the formula can be made into massage oil or aromatherapy oil; The massage oil contains 4.0%–5.5% essential oils with core efficacy. Each application is 5–8 mL, combined with a 10–15 minute massage on the abdomen and lower back. The transdermal absorption efficiency is 35%–40%. The total content of the core functional essential oils in aromatherapy essential oils is 8.0% to 10.0%. When using, mix with deionized water at a ratio of 1:100 and atomize through an ultrasonic aromatherapy diffuser. The concentration of essential oils in the aromatherapy environment is maintained at 0.1 to 0.3 mg / m³. The relief rate of emotional anxiety is 10% to 15% higher than that of massage essential oils.

[0012] Preferably, the base oil also contains 0.1% to 0.3% natural d-α-tocopherol (vitamin E), which can scavenge free radicals generated by the oxidation of essential oils.

[0013] Preferably, the formula is used to improve premenstrual tension, menopausal discomfort and mood anxiety symptoms caused by estrogen imbalance in women.

[0014] Compared with the prior art, the present invention has the following beneficial effects: Rose geranium essential oil and pure ylang-ylang essential oil are blended at a ratio of 1:1.5 to 1:2.0. Through the co-activation mechanism of estrogen receptor α / β, the total activation rate of receptors reaches 45% to 50%, which is 15% to 20% higher than that of single essential oils. After the synergistic effect of Damask rose essential oil is added, in vitro cell experiments have verified that it has a significant effect on improving symptoms related to hormone imbalance: After one month of use in 20 subjects with premenstrual tension syndrome (PMS), the breast tenderness score decreased by 38% and the mood fluctuation score decreased by 35%; After two weeks of use in 15 menopausal subjects, the frequency of hot flashes decreased from 5 to 8 times per day to 2 to 3 times, with a relief rate of 45%, which is significantly better than similar products on the market. After blending the core essential oils, gas chromatography-mass spectrometry analysis showed that the total content of linalool and geraniol acetate was ≥35% of the total content of the core essential oils. A professional fragrance evaluation panel of 10 people assessed the floral scent as having rose as the base note and ylang-ylang as the secondary note, with no pungent odor, achieving a sensory score of 8.5-9.0. Furthermore, the scent's persistence was ≥8 hours at room temperature (25℃) and relative humidity (50%). Simultaneously, the formula contained no artificial fragrances. A skin patch test was conducted on 50 people, and no adverse reactions such as redness, swelling, or itching were observed after 48 hours, achieving a 100% pass rate. This addresses the industry pain points of the incompatibility between efficacy and floral fragrance, as well as the irritation caused by artificial fragrances. It uses a blend of jojoba oil (containing 3%~5% phytosterols), sweet almond oil (containing 75%~80% unsaturated fatty acids), and evening primrose oil (containing 8%~10% gamma-linolenic acid) as base oils. Through the synergistic effect of the components, the skin penetration rate of the core essential oil reaches 25%~30% within 30 minutes, which is more than double that of a single base oil (penetration rate 10%~15%). The transdermal absorption efficiency of the massage oil is further increased to 35%~40%, ensuring that the active ingredients can quickly act on the endocrine regulatory pathway and avoid the problem of efficacy failure caused by poor absorption of active ingredients. The formula contains 0.1%~0.3% natural d-α-tocopherol (vitamin E), which can eliminate free radicals generated by the oxidation of essential oils. Stability tests show that after 6 months of storage at 40℃ and 75% relative humidity, the acid value increases by ≤0.2mgKOH / g and the peroxide value increases by ≤2.0meq / kg, which are 60% and 55% lower than the group without the addition, respectively. This effectively solves the defect of essential oils being easily oxidized and deteriorated, extending the product's shelf life to 18 months and meeting the needs of industrial storage and transportation. The formula can be flexibly made into massage oil (4.0%~5.5% of the total core essential oil) or aromatherapy oil (8.0%~10.0% of the total core essential oil) according to the usage scenario: massage oil is suitable for home / physiotherapy scenarios, and can effectively relieve physiological symptoms when used in conjunction with massage of specific areas; aromatherapy oil is atomized by ultrasonic waves and maintains a concentration of 0.1~0.3mg / m³ in the environment, which has a 10%~15% higher rate of relieving emotional anxiety than massage, achieving dual physiological and psychological regulation. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the formulation of the present invention. Detailed Implementation

[0016] The embodiments of the present invention will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of the invention.

[0017] Please see Figure 1 This invention provides an essential oil formula containing rose geranium and pure ylang-ylang to improve hormone secretion. The core of this invention lies in the three-layer system design of core efficacy essential oil + compound base oil + functional excipients. The components and process parameters are as follows: Core efficacy essential oils (total percentage 4.0%~5.8%, by total weight of the formula): Types of essential oils weight percentage Key active ingredient content Raw material source and specifications Efficacy and Function Rose Geranium Essential Oil 1.2%~1.8% Citronellol 35%~40%, Geraniol 15%~20% Pelargonium flower, extracted by CO2 supercritical fluid, purity ≥98% Activates estrogen receptor α, regulates GnRH secretion, and helps balance the endocrine system. Complete Ylang-Ylang Essential Oil 2.0%~3.0% Linalool 25%~30%, benzyl acetate 18%~22% Flowers of Ylang-ylang, CO2 supercritical extraction, purity ≥ 98% Activates estrogen receptor β, enhances mood regulation, and provides the main floral fragrance. Damask Rose Essential Oil 0.6%~1.0% Citronellol 20%~25%, Geraniol 10%~15% <![CDATA[Rose plant flower, CO2 supercritical extraction, purity ≥ 98%]]> Synergistically enhances the activity of the first two essential oils, improving the complexity of the floral fragrance. Synergistic mechanism: When rose geranium essential oil and ylang-ylang essential oil are blended at a ratio of 1:1.5 to 1:2.0, the total activation rate of estrogen receptor α / β can be increased to 45% to 50% through the "receptor co-activation" mechanism, which is 15% to 20% higher than when using a single essential oil. Damask rose essential oil can reduce the pungent smell of pure ylang-ylang essential oil while prolonging the fragrance's longevity. Complex base oil (balance, based on total formulation weight): The formula uses a blend of jojoba oil, sweet almond oil, and evening primrose oil. The specific proportions and effects are as follows: Jojoba oil (20%~30% of total base oil): Contains 3%~5% phytosterols, which are antioxidants and promote penetration, increasing the skin penetration rate of core essential oils to 25%~30%; Sweet almond oil (40%~50% of total base oil): contains 75%~80% unsaturated fatty acids (60%~65% oleic acid), which enhances skin compatibility and reduces the risk of irritation; Evening primrose oil (20%~30% of total base oil): contains 8%~10% gamma-linolenic acid, which helps regulate prostaglandin synthesis and relieve symptoms of inflammation-related hormonal imbalance. Functional excipients: Adding 0.1%~0.3% of natural d-α-tocopherol (vitamin E, purity ≥96%) as a free radical scavenger to inhibit essential oil oxidation; experiments show that after adding the tocopherol, the formula stored at 40℃ and RH75% for 6 months showed an acid value increase of ≤0.2mgKOH / g and a peroxide value increase of ≤2.0meq / kg, with stability improved by more than 60% compared to the unadded group. Preparation process: Raw material pretreatment: Place the core efficacy essential oil in a 4℃ refrigerated environment for 24 hours to equilibrate, and preheat the base oil to 20~25℃ under nitrogen protection to remove moisture (moisture content ≤0.1%). Core essential oil blending: Add rose geranium essential oil, whole ylang-ylang essential oil, and Damask rose essential oil to a sterile mixing jar (material: 316L stainless steel) in the specified proportions, stir at 200~300r / min for 10~15 minutes, and take samples to test the uniformity (coefficient of variation ≤5%). Base oil blending: Mix jojoba oil, sweet almond oil, and evening primrose oil in the specified proportions, add vitamin E, and stir at 150 rpm for 5 minutes to ensure the excipients are dissolved; Blending and Degassing: Slowly add the blended base oil to the core essential oil system, adjust the speed to 100~150 r / min, and continue stirring for 20~30 minutes, with nitrogen protection throughout (oxygen content ≤0.5%); after stirring, let stand for 1~2 hours, and then degas under vacuum (vacuum degree -0.09~-0.08MPa) to remove air bubbles; Filtration and filling: Filter through a 0.22μm polytetrafluoroethylene filter membrane, fill into brown glass containers (protected from light), seal and store in the dark (10~25℃). Application format: Massage oil: The core efficacy oil accounts for 4.0%~5.5% of the total. It is recommended to use 5~8mL each time. Massage the abdomen (clockwise circles) and the waist and back (up and down kneading) for 10~15 minutes. The transdermal absorption efficiency reaches 35%~40%. It is suitable for home or professional physiotherapy scenarios. Aromatherapy essential oils: The core efficacy essential oils account for 8.0%~10.0% of the total composition. They are mixed with deionized water at a ratio of 1:100 and then atomized in an ultrasonic aromatherapy diffuser (power 10~15W). The concentration of essential oils in the aromatherapy environment is maintained at 0.1~0.3mg / m³. Each use lasts 30~60 minutes and is suitable for enclosed spaces such as bedrooms and offices. Synergistic effects: When the core essential oils are blended, their hormone-regulating activity is increased by 15% to 30%, which can effectively reduce the premenstrual syndrome (PMS) symptom score by 30% to 40% and reduce the frequency of menopausal hot flashes by 40% to 50%. Both sensory appeal and safety are taken into consideration: the natural floral fragrance lasts for ≥8 hours (25℃, RH50%), with a sensory score of 8.5~9.0 points and no pungent odor; the human skin patch test (n=50) has a 100% pass rate and no irritation reactions such as redness, swelling, or itching; Excellent absorption and stability: The complex base oil allows the core ingredients to achieve a skin penetration rate of 25%~30% within 30 minutes, and the addition of vitamin E extends the shelf life to 18 months; You can choose between massage or aromatherapy depending on the situation. Aromatherapy has a 10% to 15% higher rate of relieving anxiety than massage, thus meeting different needs. The present invention is further illustrated by the following three embodiments, but these do not limit the scope of protection of the present invention. Example 1: Massage Oil (Preferred Formula) Components weight percentage Specifications Rose Geranium Essential Oil 1.5% <![CDATA[38% citronellol, 18% geraniol, extracted by CO2 supercritical extraction]]> Complete Ylang-Ylang Essential Oil 2.5% <![CDATA[Linalool 28%, benzyl acetate 20%, CO2 supercritical extraction]]> Damask Rose Essential Oil 0.8% <![CDATA[22% citronellol, 12% geraniol, CO2 supercritical extraction]]> Jojoba oil 18% Phytosterols 4%, Moisture ≤0.1% Sweet almond oil 45% 78% unsaturated fatty acids, 62% oleic acid Evening Primrose Oil 31.6% 9% gamma-linolenic acid, moisture ≤0.1% Natural d-α-tocopherol 0.2% 96% purity Preparation process: Follow the above process steps, mix the core essential oils for 12 minutes (250 r / min), mix the total mixture for 25 minutes (120 r / min), and deaerate for 1.5 hours. Effect detection: Sensory characteristics: The floral fragrance is based on rose, with ylang-ylang as a secondary note. It is not pungent and scores 8.8 points. Efficacy: In vitro cell experiments showed that the estrogen receptor α / β activation rate was 48%. After one month of use in 20 PMS subjects, breast tenderness scores decreased by 38% and mood fluctuation scores decreased by 35%. Stability: After 6 months of storage at 40℃ and RH75%, the acid value is 0.18 mg KOH / g and the peroxide value is 1.8 meq / kg. Example 2: Aromatherapy Essential Oils Components weight percentage Specifications Rose Geranium Essential Oil 1.8% <![CDATA[35% citronellol, 15% geraniol, CO2 supercritical extraction]]> Complete Ylang-Ylang Essential Oil 3.0% <![CDATA[Linalool 25%, benzyl acetate 18%, CO2 supercritical extraction]]> Damask Rose Essential Oil 1.0% <![CDATA[20% citronellol, 10% geraniol, CO2 supercritical extraction]]> Jojoba oil 15% Phytosterols 3%, Moisture ≤0.1% Sweet almond oil 40% 75% unsaturated fatty acids, 60% oleic acid Evening Primrose Oil 38.9% 8% gamma-linolenic acid, moisture ≤0.1% Natural d-α-tocopherol 0.3% 96% purity Preparation process: Mix the core essential oils for 15 minutes (300r / min), then mix the total mixture for 30 minutes (150r / min), and deaerate for 2 hours. Effect detection: Sensory evaluation: The floral fragrance is moderately intense, lasts for 9 hours, and has a fragrance harmony score of 8.5. Efficacy: After two weeks of aromatherapy use, 15 participants experiencing menopausal anxiety saw their SAS score decrease from 55 to 28, achieving a relief rate of 49%. Stability: After 6 months of storage at 40℃ and RH75%, the acid value is 0.19 mg KOH / g and the peroxide value is 1.9 meq / kg. Example 3: Highly stable massage oil (containing Vitamin E) Components weight percentage Specifications Rose Geranium Essential Oil 1.2% <![CDATA[Citronellol 40%, geraniol 20%, CO2 supercritical extraction]]> Complete Ylang-Ylang Essential Oil 2.0% <![CDATA[30% Linalool, 22% Benzyl Acetate, CO2 Supercritical Extraction]]> Damask Rose Essential Oil 0.6% <![CDATA[25% citronellol, 15% geraniol, extracted by CO2 supercritical extraction]]> Jojoba oil 30% Phytosterols 5%, Moisture ≤0.1% Sweet almond oil 40% 80% unsaturated fatty acids, 65% oleic acid Evening Primrose Oil 25.9% 10% gamma-linolenic acid, moisture ≤0.1% Natural d-α-tocopherol 0.3% 96% purity Effect detection: Stability: After 6 months of storage at 40℃ and RH 75%, the acid value was 0.15 mg KOH / g and the peroxide value was 1.5 meq / kg, which is better than that of Example 1; Efficacy: Estrogen receptor activation rate of 45%, transdermal absorption efficiency of 38%, meeting the needs of long-term use. Effect verification experiment: (a) Sensory evaluation experiment: Evaluation panel: 10 professional perfume tasters (5 men and 5 women, with more than 5 years of experience in the industry); Evaluation indicators: aroma intensity (1~10 points), harmony (1~10 points), persistence (hours); Results: The aroma intensity scores of Examples 1-3 were 8.2-8.8, the harmony scores were 8.0-8.8, and the persistence was 8-9 hours, all of which were better than commercially available similar products (average score 6.5, persistence 5 hours). (II) Hormone Regulation Efficacy Experiment: In vitro experiments: Using human breast cancer MCF-7 cells (containing estrogen receptors), the effects of different formulations on cell proliferation (reflecting receptor activation rate) were examined; the results showed that the activation rate of the formulation in Example 1 was 48%, which was 50% and 37% higher than that of single rose geranium essential oil (32%) and complete ylang-ylang essential oil (35%), respectively. In vivo experiment: Sixty women (30-55 years old) with mild to moderate hormonal imbalance were randomly divided into three groups (Example 1 group, commercially available group, and control group), with 20 people in each group; Example 1 group used the massage daily for 1 month; the results showed that the PMS symptom relief rate of Example 1 group was 85%, and the frequency of menopausal hot flashes decreased by 45%, which was significantly higher than that of the commercially available group (60%, 25%) and the control group (10%, 5%). (III) Safety Test: Skin irritation test: A closed patch test was conducted on 50 subjects (20-60 years old) using the formulation of Example 1. After 48 hours, no adverse reactions such as redness, swelling, or itching were observed, with a pass rate of 100%. Acute toxicity test: The formulation of Example 1 (dose 2000 mg / kg) was applied percutaneously to SD rats, and the rats were observed for 14 days. No abnormalities such as death or weight loss were observed. LD50 was [not specified]. 50 >2000mg / kg, which is practically non-toxic. This invention achieves a synergistic improvement in "hormonal regulation efficacy, natural floral fragrance, skin safety, and storage stability" through precise blending of core essential oils, optimized penetration of compound base oils, and improved preparation processes. Its technical solution can be reproduced through specific embodiments, and its effects are superior to existing technologies, demonstrating significant practical value and industrialization prospects.

[0018] The embodiments of the present invention are given for illustrative and descriptive purposes only, and are not intended to be exhaustive or to limit the invention to the forms disclosed. Many modifications and variations will be apparent to those skilled in the art. The embodiments were chosen and described in order to better illustrate the principles and practical application of the invention, and to enable those skilled in the art to understand the invention and to design various embodiments with various modifications suitable for a particular purpose.

Claims

1. An essential oil formula containing rose geranium and whole ylang-ylang to improve hormone secretion, characterized in that: By weight percentage, including essential oils and base oils; The core functional essential oil is composed of 1.2%–1.8% rose geranium essential oil, 2.0%–3.0% pure ylang-ylang essential oil, and 0.6%–1.0% Damask rose essential oil, with the remainder being base oil; Rose geranium essential oil contains 35%–40% citronellol and 15%–20% geraniol, while ylang-ylang essential oil contains 25%–30% linalool and 18%–22% benzyl acetate. The two work synergistically to activate the endocrine regulatory pathway in the human body.

2. The essential oil formulation according to claim 1, characterized in that, By weight percentage, the core active essential oils are 1.5% rose geranium essential oil, 2.5% pure ylang-ylang essential oil, and 0.8% Damask rose essential oil.

3. The essential oil formulation according to claim 1, characterized in that, The base oil is selected from at least two of jojoba oil, sweet almond oil, and evening primrose oil, wherein jojoba oil accounts for 20% to 30% of the total base oil (containing 3% to 5% phytosterols to enhance the antioxidant properties of the formula), sweet almond oil accounts for 40% to 50% of the total base oil (containing 75% to 80% unsaturated fatty acids to enhance skin compatibility), and evening primrose oil accounts for 20% to 30% of the total base oil (containing 8% to 10% γ-linolenic acid to help regulate prostaglandin synthesis).

4. The essential oil formulation according to claim 1, characterized in that, The rose geranium essential oil, ylang-ylang essential oil, and damask rose essential oil were all prepared using supercritical carbon dioxide extraction. The specific process parameters were: extraction pressure 30-40 MPa, extraction temperature 40-50℃, CO2 flow rate 20-30 L / h, separation pressure 8-10 MPa, and separation temperature 30-35℃. The essential oils prepared by this process have a purity of ≥98%, a volatile impurity content of ≤0.5%, and a retention rate of effective components that is 25% to 30% higher than that prepared by steam distillation.

5. The essential oil formulation according to claim 1, characterized in that, During preparation, first place the core efficacy essential oil in a sterile mixing tank and mix and stir at a speed of 200-300 r / min for 10-15 minutes (to ensure uniform dispersion of components and a coefficient of variation ≤5%). Then add the base oil preheated to 20-25℃, adjust the speed to 100-150 r / min and continue stirring for 20-30 minutes. After stirring, let it stand for 1-2 hours to remove air bubbles. The entire preparation process is carried out under nitrogen protection to prevent the essential oils from oxidizing and deteriorating.

6. The essential oil formulation according to claim 1, characterized in that, The weight ratio of rose geranium essential oil to ylang-ylang essential oil is 1:1.5 to 1:2.0; when the ratio is 1:1.8, the regulatory activity of both on hypothalamic gonadotropin-releasing hormone (GnRH) reaches its peak.

7. The essential oil formulation according to claim 1, characterized in that, The floral fragrance intensity of the formula was detected by gas chromatography-mass spectrometry, and the total content of linalool and geraniol acetate was not less than 35% of the total amount of the core functional essential oils.

8. The essential oil formulation according to claim 1, characterized in that, The formula can be made into massage oils or aromatherapy oils; The massage oil contains 4.0%–5.5% essential oils with core efficacy. Each application is 5–8 mL, combined with a 10–15 minute massage on the abdomen and lower back. The transdermal absorption efficiency is 35%–40%. The total content of the core functional essential oils in aromatherapy essential oils is 8.0% to 10.0%. When using, mix with deionized water at a ratio of 1:100 and atomize through an ultrasonic aromatherapy diffuser. The concentration of essential oils in the aromatherapy environment is maintained at 0.1 to 0.3 mg / m³. The relief rate of emotional anxiety is 10% to 15% higher than that of massage essential oils.

9. The essential oil formulation according to claim 1, characterized in that, The base oil also contains 0.1% to 0.3% natural d-α-tocopherol (vitamin E), which can eliminate free radicals produced by the oxidation of essential oils.

10. The essential oil formulation according to claim 1, characterized in that, The formula is used to improve symptoms of premenstrual tension, menopausal discomfort, and emotional anxiety caused by hormonal imbalance in women.

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