A composition with the function of reducing blood pressure and blood lipid, and a preparation method and application thereof

Abstract

The present application relates to the technical field of traditional Chinese medicine (medicinal and edible) composition, and discloses a composition with the functions of reducing blood pressure and reducing blood lipid, which comprises the following components in parts by weight: Gastrodia 3-9 parts, Eucommia leaf 5-15 parts, hawthorn 9-12 parts, mulberry leaf 5-10 parts, chrysanthemum 6-12 parts, Cassia seed 9-15 parts, red rice 1-3 parts, Baizhi 3-9 parts, Rehmannia 9-15 parts, Angelica 6-12 parts, American ginseng 3-6 parts, Dendrobium officinale 6-12 parts, Ganoderma 3-10 parts, saffron 1-2 parts, Cordyceps 1-3 parts, Sophora fruit 5-10 parts, and earthworm protein 1-3 parts.The composition, preparation method and application thereof can significantly reduce the content of cholesterol and triglyceride in blood, have the functions of reducing blood pressure and reducing blood lipid, and can be used for preparing medicines or functional foods for treating hypertension and hyperlipidemia.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine (food and medicine homology) composition technology, and in particular to a composition with the function of lowering blood pressure and blood lipids, its preparation method and application. Background Technology

[0002] Hypertension and hyperlipidemia are common chronic metabolic diseases and significant risk factors for cardiovascular and cerebrovascular diseases such as atherosclerosis, coronary heart disease, and stroke. They also increase the incidence of related heart, brain, and kidney diseases, especially cardiovascular and cerebrovascular diseases. Hypertension and hyperlipidemia severely impact patients' quality of life, shorten their lifespan, and impose a heavy economic and social burden on society.

[0003] Currently, Western medicine (such as ACE inhibitors and statins) is commonly used for treatment. While Western medicine treatment is effective, long-term use may be accompanied by side effects such as liver and kidney damage, muscle toxicity, and drug resistance. Therefore, developing natural, multi-target, and low-toxicity traditional Chinese medicine compound preparations is of significant clinical importance.

[0004] Traditional Chinese medicine compound formulas can simultaneously regulate blood pressure and blood lipids through the synergistic effects of multiple components, multiple targets, and multiple pathways, reducing the toxic side effects of single components. Currently, some compound formulas (such as Xuezhikang capsules) are used clinically, but the following problems still exist: ① Unclear compatibility mechanism: Some compound formulas rely solely on empirical formulation and lack modern pharmacological verification; ② Outdated preparation process: Traditional decoction methods have low extraction rates and easily destroy active ingredients; ③ Low standardization: Large batch-to-batch quality differences affect the stability of efficacy. To solve the above technical problems, this invention provides a composition with blood pressure and blood lipid lowering functions, its preparation method, and its application. Summary of the Invention

[0005] The purpose of this invention is to provide a composition with the function of lowering blood pressure and blood lipids, its preparation method and application. This composition can significantly reduce the content of cholesterol and triglycerides in the blood, and has the effects of lowering blood pressure and blood lipids. It can be used to prepare medicines or functional foods for treating hypertension and hyperlipidemia.

[0006] To achieve the above objectives, the present invention provides a composition with the function of lowering blood pressure and blood lipids, comprising the following components in parts by weight: 3-9 parts of Gastrodia elata, 5-15 parts of Eucommia ulmoides leaf, 9-12 parts of hawthorn, 5-10 parts of mulberry leaf, 6-12 parts of chrysanthemum, 9-15 parts of cassia seed, 1-3 parts of red yeast rice, 3-9 parts of Angelica dahurica, 9-15 parts of Rehmannia glutinosa, 6-12 parts of Angelica sinensis, 3-6 parts of American ginseng, 6-12 parts of Dendrobium officinale, 3-10 parts of Ganoderma lucidum, 1-2 parts of saffron, 1-3 parts of Cordyceps sinensis, 5-10 parts of Sophora japonica flower bud, and 1-3 parts of earthworm protein.

[0007] Further, it includes the following components by weight: 5 parts Gastrodia elata, 12 parts Eucommia ulmoides leaves, 10 parts hawthorn, 6 parts mulberry leaves, 8 parts chrysanthemum, 11 parts cassia seed, 2 parts red yeast rice, 6 parts Angelica dahurica, 14 parts Rehmannia glutinosa, 10 parts Angelica sinensis, 5 parts American ginseng, 9 parts Dendrobium officinale, 8 parts Ganoderma lucidum, 1 part saffron, 2 parts Cordyceps sinensis, 8 parts Sophora japonica buds, and 1 part earthworm protein.

[0008] Furthermore, the present invention also provides a method for preparing the above-mentioned composition with blood pressure and blood lipid lowering functions, comprising the following steps: Step 1: Dry and pulverize the raw materials to obtain powder, and then accurately weigh each component according to the weight parts; Step 2: Soak the raw material powder in water for 30-60 minutes. During the soaking process, add trypsin for enzymatic hydrolysis. Then, bring to a boil over high heat and simmer over low heat for 30-60 minutes. Filter to obtain filtrate and residue. Step 3: Add water to the filter residue and boil it a second time. Filter to obtain filtrate and filter residue. Combine the two filtrates to obtain the aqueous extract. Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice by reflux with 70-80% ethanol. Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to obtain an extract, and form the formulation.

[0009] Furthermore, in step 1, the drying temperature is 50-60℃, and the particle size of the powder is 80-180 mesh.

[0010] Furthermore, in step 2, the amount of trypsin added is 3%, the enzymatic hydrolysis temperature is 37-40℃, the enzymatic hydrolysis time is 45-60 min, and the pH is 7.5-8.0.

[0011] Furthermore, in steps 2 and 3, 8-10 times the amount of distilled water is added during the first and second decoctions.

[0012] Furthermore, in step 4, during ethanol extraction, 6 times the amount of ethanol is added each time, and the extraction time is 2 hours each time, at a temperature of 70-80℃.

[0013] Further, in step 5, the extract is concentrated under reduced pressure to a relative density of 1.10-1.20.

[0014] Further, in step 5, the extract is mixed with dextrin and sucrose powder, wet granulated, and dried at 60°C to obtain granules; the extract is diluted with water, honey or flavoring agent is added, filtered and sterilized, and then filled to obtain an oral liquid.

[0015] The flavoring agent is steviol glycoside or citric acid.

[0016] Furthermore, the present invention also provides the application of the above-mentioned composition with blood pressure and blood lipid lowering functions in the preparation of drugs for treating hypertension and hyperlipidemia, wherein the drugs include granules, oral liquids, capsules or tablets.

[0017] The advantages and positive effects of the composition with blood pressure and blood lipid lowering functions, its preparation method, and its application described in this invention are as follows: 1. This invention adds Gastrodia elata, Eucommia ulmoides leaves, and Angelica dahurica. Gastrodia elata and Eucommia ulmoides leaves can dilate coronary arteries in the brain, while Angelica dahurica inhibits angiotensin-converting enzyme, allowing the composition to cover different vascular areas and synergistically reduce peripheral resistance. At the same time, hawthorn promotes diuresis and sodium excretion, cassia seed facilitates intestinal lipid excretion, and reduces blood volume and lipid absorption. It also works synergistically with red yeast rice to inhibit cholesterol synthesis, Ganoderma lucidum to promote LDL metabolism, and cassia seed to block intestinal absorption, thereby blocking the rise of blood lipids from the three links of synthesis, transport, and excretion, and achieving the effect of lowering blood pressure and lipids.

[0018] 2. In this invention, water extracts (such as mulberry leaf polysaccharides and rehmannia flavonoids) are combined with alcohol extracts (such as ganoderic triterpenes and crocin) to improve the overall bioavailability. At the same time, through fermentation, active polypeptide molecules are produced, which have the effect of lowering blood pressure and lipids.

[0019] The technical solution of the present invention will be further described in detail below through embodiments. Detailed Implementation

[0020] The technical solution of the present invention will be further described below through embodiments.

[0021] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.

[0022] Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of this invention. Experimental methods in the following embodiments that do not specify specific conditions are generally determined according to national standards. Experimental instruments, equipment, and reagents in the following embodiments that do not specify their sources are all commercially available materials.

[0023] Unless otherwise defined or stated, all technical and scientific terms used in this invention have the same meaning as those skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein can be applied to the methods of this invention. It should be noted that, unless otherwise specified, the embodiments and features described in this invention can be combined with each other.

[0024] Example 1 A composition with the function of lowering blood pressure and blood lipids includes the following components in parts by weight: 3 parts Gastrodia elata, 5 parts Eucommia ulmoides leaves, 9 parts hawthorn, 5 parts mulberry leaves, 6 parts chrysanthemum, 10 parts cassia seed, 1 part red yeast rice, 3 parts Angelica dahurica, 9 parts Rehmannia glutinosa, 7 parts Angelica sinensis, 3 parts American ginseng, 6 parts Dendrobium officinale, 8 parts Ganoderma lucidum, 1 part saffron, 1 part Cordyceps sinensis, 6 parts Sophora japonica flowers, and 2 parts earthworm protein.

[0025] The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials at 50°C to obtain 100-mesh powder, and then accurately weigh each component according to the weight parts. Step 2: Soak the raw material powder in 8 times its volume of distilled water for 60 minutes. During the soaking process, add 3% of the total mass of the raw material with trypsin for enzymatic hydrolysis (enzymatic hydrolysis temperature is 37-40℃, enzymatic hydrolysis time is 45 minutes, pH is 7.5-8.0). Then bring to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain filtrate and residue. Step 3: Add 8 times the volume of distilled water to the filter residue, boil it a second time, filter to obtain filtrate and filter residue, combine the two filtrates to obtain the aqueous extract; Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice with 70% ethanol (6 times the amount of ethanol, 2 hours each time, temperature 70-80℃). Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to a relative density of 1.10, dilute the extract with water (extract:water = 1:10), add honey, filter, sterilize, and bottle to obtain the oral liquid.

[0026] Example 2 A composition with the function of lowering blood pressure and blood lipids includes the following components in parts by weight: 5 parts of Gastrodia elata, 12 parts of Eucommia ulmoides leaf, 10 parts of hawthorn, 6 parts of mulberry leaf, 8 parts of chrysanthemum, 11 parts of cassia seed, 2 parts of red yeast rice, 6 parts of Angelica dahurica, 14 parts of Rehmannia glutinosa, 10 parts of Angelica sinensis, 5 parts of American ginseng, 9 parts of Dendrobium officinale, 8 parts of Ganoderma lucidum, 1 part of saffron, 2 parts of Cordyceps sinensis, 8 parts of Sophora japonica flower bud, and 1 part of earthworm protein.

[0027] The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials at 60°C to obtain 160-mesh powder, and then accurately weigh each component according to the weight parts. Step 2: Soak the raw material powder in 8 times its volume of distilled water for 60 minutes. During the soaking process, add 3% of the total mass of the raw material with trypsin for enzymatic hydrolysis (enzymatic hydrolysis temperature is 37-40℃, enzymatic hydrolysis time is 45 minutes, pH is 7.5-8.0). Then bring to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain filtrate and residue. Step 3: Add 8 times the volume of distilled water to the filter residue, boil it a second time, filter to obtain filtrate and filter residue, combine the two filtrates to obtain the aqueous extract; Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice with 80% ethanol (6 times the amount of ethanol, 2 hours each time, temperature 70-80℃). Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to an extract with a relative density of 1.15, dilute the extract with water (extract:water = 1:10), add honey, filter, sterilize, and fill into bottles to obtain the oral liquid.

[0028] Example 3 A composition with the function of lowering blood pressure and blood lipids includes the following components in parts by weight: 9 parts of Gastrodia elata, 15 parts of Eucommia ulmoides leaf, 11 parts of hawthorn, 10 parts of mulberry leaf, 9 parts of chrysanthemum, 14 parts of cassia seed, 2 parts of red yeast rice, 5 parts of Angelica dahurica, 15 parts of Rehmannia glutinosa, 6 parts of Angelica sinensis, 5 parts of American ginseng, 13 parts of Dendrobium officinale, 10 parts of Ganoderma lucidum, 2 parts of saffron, 1 part of Cordyceps sinensis, 9 parts of Sophora japonica flower bud, and 3 parts of earthworm protein.

[0029] The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials at 55°C to obtain 180-mesh powder, and then accurately weigh each component according to the weight parts. Step 2: Soak the raw material powder in 8 times its volume of distilled water for 60 minutes. During the soaking process, add 3% of the total mass of the raw material with trypsin for enzymatic hydrolysis (enzymatic hydrolysis temperature is 37-40℃, enzymatic hydrolysis time is 45 minutes, pH is 7.5-8.0). Then bring to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain filtrate and residue. Step 3: Add 8 times the volume of distilled water to the filter residue, boil it a second time, filter to obtain filtrate and filter residue, combine the two filtrates to obtain the aqueous extract; Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice with 70% ethanol (6 times the amount of ethanol, 2 hours each time, temperature 70-80℃). Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to a relative density of 1.20, dilute the extract with water (extract:water = 1:10), add honey, filter, sterilize, and bottle to obtain the oral liquid.

[0030] Comparative Example 1 A composition with the function of lowering blood pressure and blood lipids includes the following components in parts by weight: 5 parts of Gastrodia elata, 12 parts of Eucommia ulmoides leaf, 10 parts of hawthorn, 6 parts of mulberry leaf, 8 parts of chrysanthemum, 11 parts of cassia seed, 2 parts of red yeast rice, 6 parts of Angelica dahurica, 14 parts of Rehmannia glutinosa, 10 parts of Angelica sinensis, 5 parts of American ginseng, 9 parts of Dendrobium officinale, 8 parts of Ganoderma lucidum, 1 part of saffron, 2 parts of Cordyceps sinensis, 8 parts of Sophora japonica flower bud, and 1 part of earthworm protein.

[0031] The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials at 60°C to obtain 160-mesh powder, and then accurately weigh each component according to the weight parts. Step 2: Soak the raw material powder in 8 times its volume of distilled water for 60 minutes, then bring it to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain the filtrate and residue. Step 3: Add 8 times the volume of distilled water to the filter residue, boil it a second time, filter to obtain filtrate and filter residue, combine the two filtrates to obtain the aqueous extract; Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice with 80% ethanol (6 times the amount of ethanol, 2 hours each time, temperature 70-80℃). Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to an extract with a relative density of 1.15, dilute the extract with water (extract:water = 1:10), add honey, filter, sterilize, and fill into bottles to obtain the oral liquid.

[0032] Comparative Example 2 A composition with the function of lowering blood pressure and blood lipids includes the following components in parts by weight: 5 parts of Gastrodia elata, 12 parts of Eucommia ulmoides leaf, 10 parts of hawthorn, 6 parts of mulberry leaf, 8 parts of chrysanthemum, 11 parts of Prunella vulgaris, 2 parts of red yeast rice, 6 parts of Angelica dahurica, 14 parts of Rehmannia glutinosa, 10 parts of Angelica sinensis, 5 parts of American ginseng, 9 parts of Dendrobium officinale, 8 parts of Ganoderma lucidum, 1 part of saffron, 2 parts of Cordyceps sinensis, 8 parts of Sophora japonica flower bud, and 1 part of earthworm protein.

[0033] The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials at 60°C to obtain 160-mesh powder, and then accurately weigh each component according to the weight parts. Step 2: Soak the raw material powder in 8 times its volume of distilled water for 60 minutes. During the soaking process, add 3% of the total mass of the raw material with trypsin for enzymatic hydrolysis (enzymatic hydrolysis temperature is 37-40℃, enzymatic hydrolysis time is 45 minutes, pH is 7.5-8.0). Then bring to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain filtrate and residue. Step 3: Add 8 times the volume of distilled water to the filter residue, boil it a second time, filter to obtain filtrate and filter residue, combine the two filtrates to obtain the aqueous extract; Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice with 80% ethanol (6 times the amount of ethanol, 2 hours each time, temperature 70-80℃). Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to an extract with a relative density of 1.15, dilute the extract with water (extract:water = 1:10), add honey, filter, sterilize, and fill into bottles to obtain the oral liquid.

[0034] Comparative Example 3 A composition with the function of lowering blood pressure and blood lipids includes the following components in parts by weight: 5 parts of Gastrodia elata, 12 parts of Eucommia ulmoides leaf, 10 parts of lotus leaf, 6 parts of mulberry leaf, 8 parts of chrysanthemum, 11 parts of cassia seed, 2 parts of red yeast rice, 6 parts of Angelica dahurica, 14 parts of Rehmannia glutinosa, 10 parts of Angelica sinensis, 5 parts of American ginseng, 9 parts of Dendrobium officinale, 8 parts of Ganoderma lucidum, 1 part of saffron, 2 parts of Cordyceps sinensis, 8 parts of Sophora japonica flower bud, and 1 part of earthworm protein.

[0035] The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials at 60°C to obtain 160-mesh powder, and then accurately weigh each component according to the weight parts. Step 2: Soak the raw material powder in 8 times its volume of distilled water for 60 minutes. During the soaking process, add 3% of the total mass of the raw material with trypsin for enzymatic hydrolysis (enzymatic hydrolysis temperature is 37-40℃, enzymatic hydrolysis time is 45 minutes, pH is 7.5-8.0). Then bring to a boil over high heat and simmer over low heat for 30 minutes. Filter to obtain filtrate and residue. Step 3: Add 8 times the volume of distilled water to the filter residue, boil it a second time, filter to obtain filtrate and filter residue, combine the two filtrates to obtain the aqueous extract; Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice with 80% ethanol (6 times the amount of ethanol, 2 hours each time, temperature 70-80℃). Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to an extract with a relative density of 1.15, dilute the extract with water (extract:water = 1:10), add honey, filter, sterilize, and fill into bottles to obtain the oral liquid.

[0036] Effect test The oral solutions prepared in Examples 1-3 and Comparative Examples 1-3 were fed to rats for efficacy testing.

[0037] (1) Blood lipid-lowering test: High-fat feed formula: Add 20.0% sucrose, 15.0% lard, 1.2% cholesterol, and 0.2% sodium cholate to the basal feed.

[0038] SPF-grade male SD rats were introduced into an SPF environment and fed a basal diet for 7 days, then randomly divided into 8 groups: blank control group, high-fat model group, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group, with 10 rats in each group. The normal control group was fed a regular diet, the high-fat model group was fed a high-fat diet, and Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group were fed a high-fat diet. Simultaneously, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group were administered the corresponding oral solution (10 mL) by gavage, while the normal control group and the high-fat model group were administered an equal volume of distilled water by gavage. Gavage was performed once daily for 30 consecutive days. The grouping and treatment details are shown in Table 1. Table 1 Grouping and Processing Status

[0039] After the experiment, after fasting for 16 hours, 1.5 mL of blood was collected from the orbital vein, the serum was separated, and the serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-CH), and low-density lipoprotein cholesterol (LDL-CH) levels of rats were measured using a kit.

[0040] The results are shown in Table 2: Table 2. Blood lipid component levels (mmol / L)

[0041] Compared with the high-fat model group, P < 0.05 P < 0.01 indicates a highly significant difference.

[0042] Table 2 shows that, compared with the high-fat model group, the serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-CH) levels of rats in Examples 1, 2, and 3 were significantly reduced, while the high-density lipoprotein cholesterol (HDL-CH) level tended to normalize. Furthermore, the comprehensive analysis indicates that Example 2 showed the best effect. This demonstrates that the compositions prepared in Examples 1, 2, and 3 can significantly reduce blood cholesterol levels, thus playing a role in lowering blood lipids. Comparative Examples 1-3 did not show significant improvement, indicating that their intervention effect was limited, and therefore their lipid-lowering effect was also limited.

[0043] (2) Blood pressure lowering test: Clean-grade spontaneously hypertensive (SHR) rats, male, weighing 180-210g, were selected. They were acclimatized for one week before the experiment.

[0044] SHR rats were randomly divided into 7 groups: SHR model group, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group, with 10 rats in each group. Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group were administered their respective oral solutions (10 mL) by gavage, while the SHR model group was administered an equal volume of distilled water by gavage. Gavage was administered once daily for 4 consecutive weeks, with normal food and water intake during the experiment. Normal SD rats were selected as the control group and administered an equal volume of distilled water by gavage. The grouping and treatment details are shown in Table 3. Table 3 Grouping and Processing Status

[0045] After the experiment, blood pressure (systolic blood pressure) was measured using the tail pulse method. The results are shown in Table 4: Table 4 Blood Pressure (mmHg)

[0046] Compared with the SHR model group, P < 0.05 P < 0.01 indicates a highly significant difference.

[0047] Table 4 shows that after one week of gavage, the composition began to show a significant antihypertensive effect on hypertensive rats, which continued until the end of the experiment. From the first week, the blood pressure of SHR rats in groups 1, 2, and 3 was significantly lower than that of the SHR model control group (P<0.05). This indicates that the compositions prepared in Examples 1, 2, and 3 can significantly alleviate hypertension. By the fourth week, the blood pressure of rats in group 2 reached the level of normal rats. This indicates that the combination prepared in Example 2 has a better antihypertensive effect.

[0048] Therefore, the present invention employs the above-mentioned composition with blood pressure and blood lipid lowering functions, its preparation method and application. This composition can significantly reduce the content of cholesterol and triglycerides in the blood, and has the effects of lowering blood pressure and blood lipids. It can be used to prepare medicines or functional foods for treating hypertension and hyperlipidemia.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A method for preparing a composition with blood pressure and blood lipid lowering functions, characterized in that, The composition is made from the following components in parts by weight: 5 parts Gastrodia elata, 12 parts Eucommia ulmoides leaves, 10 parts hawthorn, 6 parts mulberry leaves, 8 parts chrysanthemum, 11 parts cassia seed, 2 parts red yeast rice, 6 parts Angelica dahurica, 14 parts Rehmannia glutinosa, 10 parts Angelica sinensis, 5 parts American ginseng, 9 parts Dendrobium officinale, 8 parts Ganoderma lucidum, 1 part saffron, 2 parts Cordyceps sinensis, 8 parts Sophora japonica buds, and 1 part earthworm protein; The preparation method includes the following steps: Step 1: Dry and pulverize the raw materials to obtain powder, and then accurately weigh each component according to the weight parts; Step 2: Soak the raw material powder in water for 30-60 minutes. During the soaking process, add trypsin for enzymatic hydrolysis. Then, bring to a boil over high heat and simmer over low heat for 30-60 minutes. Filter to obtain filtrate and residue. Step 3: Add water to the filter residue and boil it a second time. Filter to obtain filtrate and filter residue. Combine the two filtrates to obtain the aqueous extract. Step 4: Dry the filter residue after the second decoction, then put it into the extraction tank and extract it twice by reflux with 70-80% ethanol. Combine the ethanol extracts to obtain the alcohol extract. Step 5: Combine the water extract and alcohol extract, concentrate under reduced pressure at 60°C to obtain an extract, and form the formulation.

2. The method for preparing a composition with antihypertensive and lipid-lowering functions according to claim 1, characterized in that: In step 1, the drying temperature is 50-60℃ and the particle size of the powder is 80-180 mesh.

3. The method for preparing a composition with antihypertensive and lipid-lowering functions according to claim 1, characterized in that: In step 2, the amount of trypsin added is 3%, the enzymatic hydrolysis temperature is 37-40℃, the enzymatic hydrolysis time is 45-60min, and the pH is 7.5-8.

0.

4. A method for preparing a composition with antihypertensive and lipid-lowering functions according to claim 1, characterized in that: In steps 2 and 3, add 8-10 times the amount of distilled water during the first and second decoction.

5. A method for preparing a composition with antihypertensive and lipid-lowering functions according to claim 1, characterized in that: In step 4, during ethanol extraction, add 6 times the amount of ethanol each time, for 2 hours each time, at a temperature of 70-80℃.

6. A method for preparing a composition with antihypertensive and lipid-lowering functions according to claim 1, characterized in that: In step 5, the extract is concentrated under reduced pressure to a relative density of 1.10-1.

20.

7. A method for preparing a composition with antihypertensive and lipid-lowering functions according to claim 1, characterized in that: In step 5, the extract is mixed with dextrin and sucrose powder, wet granulated, and dried at 60°C to obtain granules; the extract is diluted with water, honey is added, filtered, sterilized, and then filled to obtain an oral liquid.

8. The use of the composition prepared by the method of claim 1 in the preparation of drugs for treating hypertension and hyperlipidemia, characterized in that: The drug may be in the form of granules, oral liquid, capsules or tablets.

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