Herbicide composition

Abstract

The invention relates to a herbicide composition, the active ingredients of which contain butachlor, clomazone and oxaziclomefone, and an optional herbicide safener. Wherein the butachlor, the clomazone and the oxaziclomefone are compounded, so that a synergistic effect is achieved. The herbicide composition can further comprise an agriculturally acceptable auxiliary agent and a carrier, and can be prepared into agriculturally acceptable dosage forms. In addition, the invention also relates to an application of the herbicide composition for preventing and treating agricultural weeds.

Description

Technical Field

[0001] This invention relates to the agricultural field, and more specifically to a herbicide composition containing butachlor, isoxaflutole, and oxadiazon, and its application in controlling agricultural weeds. Background Technology

[0002] Butachlor is a selective systemic herbicide of the amide class. The pure product is a pale yellow oily liquid, poorly soluble in water but readily soluble in organic solvents. It is mainly absorbed through the young shoots and roots of weeds and translocated throughout the entire plant, inhibiting protein synthesis, interfering with cell division and growth, and ultimately causing weed death. Butachlor is mainly used in rice paddies, but can also be used in fields of wheat, corn, cotton, peanuts, cabbage, spinach, and other crops to control weeds such as barnyard grass, crabgrass, foxtail, sedge, rice sedge, duckweed, jointed greens, and amaranth. Its primary application method is pre-emergence soil treatment.

[0003] Isoxam, also known as cyclohexane, is an organic heterocyclic selective pre-emergence herbicide. The pure product is a colorless, transparent to light brown viscous liquid. It is a photosynthesis inhibitor that is absorbed through roots and young shoots and translocated upwards to all parts of the plant, thereby inhibiting the synthesis of isoprene compounds and hindering the biosynthesis of carotene and chlorophyll in sensitive plants. Although the plant may still germinate and emerge, it lacks pigment and dies within a short period. This herbicide is characterized by its long-lasting effect; a single application can maintain its efficacy throughout the crop's entire growth cycle. It can be applied flexibly, either pre-emergence soil sealing or post-emergence foliar application. It can be used in fields of corn, rice, wheat, soybeans, potatoes, peanuts, sugarcane, tobacco, and other crops to control annual grasses and broadleaf weeds, including barnyard grass, foxtail grass, crabgrass, goosegrass, purslane, lambsquarters, knotweed, cocklebur, black nightshade, velvetleaf, dayflower, thistle, and sow thistle.

[0004] Oxaziclomefone, developed by Aventis, is a novel herbicide of the oxaziclomefone class. The pure product is a white crystalline powder and is a systemic herbicide for rice paddies. It is primarily absorbed by the roots and base of the stems and leaves of weeds, inhibiting the growth of target plant cells. Oxaziclomefone is highly safe for transplanted rice and is highly effective against annual rice weeds with a long residual effect. It can control barnyard grass, goosegrass, sedge, foxtail, purslane, amaranth, and other annual grasses, as well as some broadleaf weeds.

[0005] CN108477183A discloses a ternary herbicidal composition, the active ingredients of which are propargite, isoxaflutole, butachlor, or pretilachlor, and the ternary herbicidal composition is used to control weeds in farmland.

[0006] CN112205402A discloses a herbicidal composition comprising butachlor, isoxaflutole, and butachlor, which is used to control weeds in paddy fields.

[0007] CN1276153A discloses a herbicide mainly composed of isoxaflutole and amides (such as acetochlor, metolachlor, butachlor, etc.). When applied to rapeseed fields and soybean fields, it can kill broadleaf weeds and grass weeds throughout their entire growth period. It is safe and reliable and will not cause phytotoxicity.

[0008] CN108651483A discloses a herbicide composition containing oxadiazon and butachlor. The composition has better efficacy than the individual components when applied alone, exhibiting a synergistic effect, broadening the weed control spectrum, controlling weeds in paddy fields with a single application, and is safe for crops.

[0009] CN111328815A discloses a herbicidal composition containing bicyclosulfuron, oxadiazon, and butachlor. The herbicidal composition has a significant synergistic effect, which significantly improves the control effect on weeds and expands the weed control spectrum compared with the use of each single agent alone or in binary combination.

[0010] No reports were found regarding the combination of butachlor, isoxaflutole, and oxadiazon. Summary of the Invention

[0011] Through experiments, the inventors discovered that the herbicide composition consisting of butachlor, isoxaflutole, and oxadiazon has a significant synergistic effect in weed control.

[0012] This invention relates to a herbicide composition, wherein the active ingredients of the herbicide composition include butachlor, isoxaflutole, and oxadiazon; the weight ratio of the three active ingredients is 30-60:6-15:0.5-2.

[0013] Within the above-mentioned weight ratio range of the present invention, wherein: The weight ratio values ​​of butachlor can be selected as 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, and 60. The weight ratio of isoxaflutole can be selected as 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15. The weight ratio of oxadiazon can be selected as 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or 2.

[0014] Furthermore, in the herbicide composition of the present invention, the weight ratio of butachlor, isoxaflutole, and oxadiazon is preferably 40-55:8-12:0.8-1.5.

[0015] Furthermore, in the herbicide composition of the present invention, the weight ratio of butachlor, isoxaflutole, and oxadiazon is more preferably 50:10:1.

[0016] In one embodiment of the present invention, the herbicide composition further comprises a herbicide safener, said herbicide safener including one or more of the following: cyclohexane, cyclohexidine, cyclohexane, cyclohexidine, cyclohexidine, cyclohexidine ester, and cyclohexidine quinalpine. In one embodiment of the present invention, the herbicide safener is preferably cyclohexidine.

[0017] In the herbicide compositions within any weight ratio range described in this invention, the corresponding weight ratio of the herbicide safener can be 3-8, for example 3, 4, 5, 6, 7, or 8. Preferably, it is 4-6, and more preferably 5.

[0018] Specifically, when the herbicide composition of the present invention includes a herbicide safener, the weight ratio of each component is 30-60:6-15:0.5-2:3-8; preferably 40-55:8-12:0.8-1.5:4-6; more preferably 50:10:1:5.

[0019] In one embodiment of the present invention, the herbicide composition of the present invention may further comprise agriculturally acceptable adjuvants and / or carriers, and be prepared into an agriculturally acceptable formulation.

[0020] In one embodiment of the present invention, the agriculturally acceptable formulation contains 5-90% by weight of the active ingredient, preferably 10-80%, and more preferably 20-70%.

[0021] The agriculturally acceptable formulations include emulsifiable concentrates, water-in-oil emulsions, microemulsions, and suspensions. Emulsifiable concentrates are preferred. The methods for preparing the agriculturally acceptable formulations are well known to those skilled in the art.

[0022] In the preparation of the above-mentioned agriculturally acceptable formulations, the agriculturally acceptable adjuvants and / or carriers used include, but are not limited to: solvents, emulsifiers, dispersants, wetting agents, thickeners, antifreeze agents, defoamers, and liquid carriers. The solvent may be selected from one or more of N,N-dimethylformamide, ethyl acetate, xylene, chloroform, dichloromethane, cyclohexane, ethyl glycol ether, cyclohexanone, N-methylpyrrolidone, N,N-dimethyloctamide, N,N-dimethyldecylamide, and methyl glycol ether.

[0023] The emulsifier may be selected from one or more of the following: fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, lignin sulfonate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, naphthalene sulfonic acid formaldehyde condensate salt, styrene-phenyl polyoxyethylene ether, phenethylphenol polyoxyethylene polyoxypropylene ether, polyoxyethylene sorbitan fatty acid ester, nonylphenol polyoxyethylene ether phosphate, phenylphenol polyoxyethylene ether phosphate, sorbitan monostearate polyoxyethylene ether, and sorbitan fatty acid ester polyoxyethylene ether.

[0024] The dispersant may be selected from one or more of the following: nonylphenol polyoxyethylene ether, alkyl naphthalene sulfonate, polyoxyethylene alkyl aryl ether, lignin sulfonate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, sodium p-hydroxyphenyl lignin sulfonate, polyoxyethylene lanolin alcohol, naphthalene sulfonic acid formaldehyde condensate salts, polyoxyethylene sorbitan fatty acid ester, fatty alcohol polyoxyethylene ether sulfate, and alkylphenol polyoxyethylene ether formaldehyde condensate.

[0025] The wetting agent may be selected from one or more of the following: sodium dodecyl sulfate, calcium dodecylbenzene sulfonate, sodium lauroyl sarcosinate, sodium N-lauroyl glutamate, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, trisiloxane polyoxyethylene ether, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, alkylphenol polyoxyethylene ether phosphate, triphenylethylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, and fatty alcohol polyoxyethylene ether.

[0026] The thickener may be selected from one or more of gum arabic, carboxymethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, gelatin, polyvinyl alcohol, magnesium aluminum silicate, and sodium alginate.

[0027] The antifreeze agent may be selected from one or more of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, and sorbitol.

[0028] The defoamer may be selected from one or more of silicone, butyl phosphate, isobutyl phosphate, and n-octanol.

[0029] The liquid carrier may be selected from one or more of water, castor oil, soybean oil, and mineral oil.

[0030] Another aspect of the present invention relates to the application of the herbicide composition for the control of agricultural weeds in crop fields. The method of application of the herbicide composition is well known to those skilled in the art, such as pre-emergence soil application or post-emergence spraying. The dosage is determined by those skilled in the art based on factors such as the properties of the active ingredient, recommended dosage, and the weed occurrence in the field.

[0031] The crops mentioned include, but are not limited to: rice, wheat, corn, soybeans, peanuts, cotton, potatoes, tobacco, and vegetables. Rice is preferred.

[0032] The agricultural weeds include: barnyard grass, Echinochloa crus-galli, Eclipta prostrata, Kentucky bluegrass, Commelina communis, Setaria viridis, Crataegus pinnatifida, Eleusine indica, Portulaca oleracea, Chenopodium album, Polygonum hydropiper, etc. Barnyard grass and Echinochloa crus-galli are preferred. Detailed Implementation

[0033] The present invention will be further described below with reference to embodiments, but the present invention is not limited thereto.

[0034] Unless otherwise specified, all percentages mentioned in the following examples are weight percentages.

[0035] All experimental materials, reagents, and pharmaceuticals used in the following embodiments of the present invention are obtained from the applicant's laboratory or through commercially available products.

[0036] I. Herbicidal Activity Test 1. Herbicidal activity test against barnyard grass Test target: barnyard grass; Test reagents: butachlor technical grade, isoxaflutole technical grade, and oxadiazon technical grade. When preparing the reagents, first dissolve them in an appropriate amount of acetone, then use a 0.5% Tween 80 aqueous solution to prepare the required concentration.

[0037] Experimental Method: Soil with a soil-to-fertilizer ratio of 2:1 was placed in plastic pots, moistened with water, and barnyard grass was sown at a density of 20 plants per pot. A layer of fine soil was then added, followed by watering to maintain a water level. The pots were then placed in a light-filled greenhouse for cultivation. Once the barnyard grass reached the 1-2 leaf stage, 15 seedlings of uniform growth were selected per pot and sprayed using a foliar spraying method according to the prescribed dosage. A mobile spray tower was used for spraying, with a spray pressure of 240 kPa and a spray volume of 450 L / hm². 2 After application, the plants were placed in a greenhouse for further cultivation. A 0.5% Tween-80 aqueous solution without the pesticide was used as a blank control. Each treatment was replicated four times. Fifteen days after soil treatment, the fresh weight of the above-ground portion of the weeds in each treatment was weighed, and the fresh weight control efficacy was calculated.

[0038]

[0039] E: Fresh weight efficacy; C: Fresh weight of the above-ground portion of the control weeds; T: Fresh weight of the above-ground portion of the processed weeds; Then, the combined effect of the compositions was calculated according to the Colby formula (SRColby, Calculating Synergistic and Antagonistic Response of Herbicide Combinations. Weeds, 1967): E0 = X + Y - XY / 100………(1); or E0=X+Y+Z-(XY+XZ+YZ) / 100+XYZ / 10000…………(2) X represents the efficacy when active ingredient A is applied at a dosage of m, expressed as a percentage of the untreated control group. Y represents the efficacy when active ingredient B is applied at an application rate of n, expressed as a percentage of the untreated control group. Z represents the efficacy when active ingredient C is applied at the dosage of r, expressed as a percentage of the untreated control group; E0 represents the theoretical efficacy when active components A and B are applied at dosages of m and n, expressed as a percentage of the untreated control group (Formula 1); or, E0 represents the theoretical efficacy when active components A, B, and C are applied at dosages of m, n, and r, expressed as a percentage of the untreated control group (Formula 2).

[0040] If the observed efficacy (actual efficacy) is higher than the theoretical value calculated by the above formula, the composition has superadditivity, that is, there is a synergistic effect.

[0041] The measurement results are shown in Table 1 below.

[0042] Table 1. Results of the composition on barnyard grass

[0043] Table 1 shows that the combination of butachlor, isoxaflutole, and oxadiazon has a significant synergistic effect compared to each single agent and their combinations, especially when the dosage of butachlor, isoxaflutole, and oxadiazon is (50+10+1) ga.i. / ha.

[0044] 2. Herbicidal activity test of Echinochloa crus-galli. Following the same method described above, the herbicidal activity of *Euphorbia lathyris* was tested, and the results are shown in Table 2 below.

[0045] Table 2. Results of the composition on Ephedra sinica

[0046] Table 2 shows that the combination of butachlor, isoxaflutole, and oxadiazon has a significant synergistic effect compared to each single agent and their combinations, especially when the dosage of butachlor, isoxaflutole, and oxadiazon is (50+10+1) ga.i. / ha.

[0047] II. Formulation Examples Example 1: 53.5% Butachlor·Isoxadixyl·Oxalisacin EC Butachlor 40%, isoxaflutole 12%, oxadiazon 1.5%, cyhalofop-p-ethyl 5%, styrene-phenyl polyoxyethylene ether 7%, N-lauroyl glutamate sodium 7%, N,N-dimethyloctylamide to make up to 100%.

[0048] The preparation method is as follows: add the active ingredient of the prescribed amount to the solvent of the prescribed amount, then add other auxiliary agents, mix evenly, and the product is obtained.

[0049] Example 2: 61% Butachlor·Isoxadixyl·Oxalisacin EC Butachlor 50%, isoxaflutole 10%, oxadiazon 1%, cyhalofop-P-ethyl 5%, sodium lignosulfonate 8%, nonylphenol polyoxyethylene ether 4%, N,N-dimethyloctylamide to make up to 100%.

[0050] The preparation method is the same as in Example 1.

[0051] Example 3: 63.8% Butachlor·Isoxadixyl·Oxalisacin EC Butachlor 55%, isoxaflutole 8%, oxadiazon 0.8%, cyhalofop-p-ethyl 5%, calcium dodecylbenzenesulfonate 8%, trisiloxane polyoxyethylene ether 7%, N,N-dimethyloctylamide to make up to 100%.

[0052] The preparation method is the same as in Example 1.

[0053] Example 4: 47% Butachlor·Isoxadixyl·Oxalisacin EC Butachlor 30%, isoxaflutole 15%, oxadiazon 2%, cyclohexane 5%, phenylphenol polyoxyethyl ether phosphate 5%, sodium p-hydroxyphenyl lignin sulfonate 4%, N,N-dimethyldecylamide to make up to 100%.

[0054] The preparation method is the same as in Example 1.

[0055] Example 5: 66.5% Butachlor·Isoxadixyl·Oxalisacin EC Butachlor 60%, isoxaflutole 6%, oxadiazon 0.5%, cyhalofop-P-ethyl 5%, polyoxyethylene sorbitan fatty acid ester 8%, sodium dodecyl sulfate 6%, N,N-dimethyldecylamide to make up to 100%.

[0056] The preparation method is the same as in Example 1.

[0057] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A herbicide composition, characterized in that, The active ingredients of the herbicide composition include butachlor, isoxaflutole, and oxadiazon; the weight ratio of the three active ingredients is 30-60:6-15:0.5-2.

2. The herbicide composition according to claim 1, characterized in that, The preferred weight ratio of butachlor, isoxaflutole, and oxadiazon is 40-55:8-12:0.8-1.

5.

3. The herbicide composition according to claim 1 or 2, characterized in that, The herbicide composition further includes a herbicide safener.

4. The herbicide composition according to claim 3, characterized in that, The herbicide safener includes one or more of the following: cyclohexane, cyclohexidine, cyclohexane, cyclohexazole, cyclohexanenitrile, cyclohexane ester, and cyclohexanequinone.

5. The herbicide composition according to claim 3 or 4, characterized in that, The weight ratio of butachlor, isoxaflutole, oxadiazon, and the herbicide safener is 30-60:6-15:0.5-2:3-8.

6. The herbicide composition according to any one of claims 1-5, characterized in that, The herbicide composition further comprises agriculturally acceptable adjuvants and / or carriers, and is formulated into an agriculturally acceptable formulation.

7. The herbicide composition according to claim 6, characterized in that, Agriculturally acceptable formulations include emulsifiable concentrates, suspensions, emulsions, and microemulsions.

8. The herbicide composition according to claim 6, characterized in that, The agriculturally acceptable adjuvants and / or carriers include solvents, emulsifiers, dispersants, wetting agents, thickeners, antifreeze agents, defoamers, and liquid carriers.

9. The application of the herbicide composition according to any one of claims 1-8 for the control of agricultural weeds.

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