Cosmetic composition containing oxytocin secretion promoter containing oranges essential oil, and multi-aspect mood improving agent

Abstract

The present invention relates to a cosmetic composition containing an oxytocin secretion promoter containing an oranges essential oil, and a multi-aspect emotion improving agent. Provided is an oxytocin secretion-promoting agent which has a mood-improving effect in multiple aspects such as a reduction in tiredness and an improvement in positive mood, and also has a skin-improving effect such as a significant improvement in skin laxity, pores, and dry skin. The oxytocin secretion promoter contains orange essential oil.

Description

Technical Field

[0001] This invention relates to highly safe oxytocin secretion promoters derived from natural ingredients, as well as skin improvers and various mood improvers containing the aforementioned oxytocin secretion promoters. Furthermore, this invention also relates to fragrance compositions, cosmetics, or oral compositions containing the aforementioned oxytocin secretion promoters. Background Technology

[0002] In recent years, the environment around us has changed significantly due to responses to COVID-19, such as home isolation, remote work, and online teaching, as well as the deteriorating global situation. The resulting increase in stress is worrying. This stress can be felt by people of all ages and genders, and excessive stress may lead to obesity, diabetes, sleep disorders, mood disorders, and other health problems.

[0003] In addition, as a countermeasure against infectious diseases and air pollution, wearing masks has become a habit. Wearing masks itself has also become a factor that induces stress. Some people have pointed out that wearing masks for a long time can affect skin condition, such as the stuffiness caused by wearing masks, the dryness caused by removing and putting on masks, the increased visibility of pores, the friction between the mask material and the skin, and the tendency for cheeks to become loose and nasolabial folds to deepen due to tension in the temporalis muscles caused by wearing masks.

[0004] Oxytocin, also known as the bond hormone or happiness hormone, is known to have stress-suppressing effects. It has also been reported that oxytocin not only suppresses stress but also improves skin (Non-Patent Literature 1).

[0005] As methods to promote the secretion of oxytocin, proposed methods include (1) skin contact; (2) altruistic actions (volunteer activities, etc.); (3) communication (eye contact, gentle conversation); (4) stimulation of the five senses; (5) keeping pets; (6) activities with family (eating together), etc. (Non-Patent Literature 2).

[0006] However, since people who experience stress vary greatly in terms of gender, age, and living environment, methods other than those mentioned above, such as non-invasive and daily stress relief methods, are preferred.

[0007] By promoting oxytocin secretion, it is expected to simultaneously satisfy stress suppression, improve various emotions, and even improve skin.

[0008] Furthermore, it is hoped that the "fragrance" will promote the secretion of oxytocin by unconsciously entering the body through the nasal cavity with each breath and having an effect.

[0009] The following technologies exist that utilize fragrance components to promote oxytocin secretion: a technology that utilizes the fragrance component of black tea, called dehydrolinalool, to promote oxytocin secretion (Patent Document 1); and oxytocin production promoters containing synthetic fragrances such as rose oil, ethyltrimethylcyclopentenylbutenol, methyltrimethylcyclopentenylpentanol, and hexahydrohexamethylcyclopentylbenzopyran (Patent Document 2), which are used as fragrance ingredients in perfumes. Technologies exist that use cinnamon extract, used as a spice, as an active ingredient to promote the proliferation of oxytocin receptors and improve skin elasticity and bouncy (Patent Document 3); and extracts from plants of the Caryophyllaceae family that minimize the appearance of pores (Patent Document 4). However, to date, there is no oxytocin secretion promoter derived from natural ingredients and possessing a refreshing citrus fragrance.

[0010] On the other hand, it is known that the psychological and physiological effects of fragrance are greatly influenced by the consumer's preference for that fragrance (Non-Patent Literature 3). Therefore, there is a problem that the limited variety of fragrances makes it difficult to cater to the diverse fragrance preferences of consumers. In particular, Japanese people tend to prefer citrus-based fragrances (Non-Patent Literature 4), and although there are many cosmetics and food products with citrus-based fragrances on the market, it is difficult to apply them to such products, which is an important issue.

[0011] Existing technical documents

[0012] Patent documents

[0013] Patent Document 1: Japanese Patent Application Publication No. 2023-114046

[0014] Patent Document 2: Japanese Patent Application Publication No. 2011-98898

[0015] Patent Document 3: Japanese Patent Application Publication No. 2020-200240

[0016] Patent Document 4: Japanese Patent Application Publication No. 2016-222564

[0017] Non-patent literature

[0018] Non-patent literature 1: Sakamoto et al., "Correlation analysis of oxytocin changes induced by tactile stimulation that evokes pleasure and skin texture", Journal of the Japan Cosmetic Technologists Association, 2022, Vol.56, No.3, pp.247-252.

[0019] Non-patent literature 2: Hajime Yamaguchi, “Skin sensation and mind”, Journal of the Japan Society of Perfume and Cosmetics, 2022, Vol.46, No.1, pp.51-58

[0020] Non-patent literature 3: O. Alaoui-Ismaili et al, “Odor hedonics: connection with emotional response estimated by autonomic parameters” Chem. Senses 22:237-248, (1997)

[0021] Non-patent literature 4: Rieko Kawamoto et al., “A Study on the Influencing Factors Related to Fragrance in Daily Life”, Applied Psychology Research, 2013, Vol.39, No.1, pp.25-32. Summary of the Invention

[0022] The purpose of this invention is to provide a citrus-based fragrance that can promote oxytocin secretion through a simple, non-invasive method. This oxytocin secretion promoter is derived from nature and is highly safe. It also produces skin-improving effects such as skin relaxation and pore reduction, dry skin improvement, as well as mood-enhancing effects such as reduced fatigue and improved positive mood.

[0023] In order to achieve the above objectives, the inventors studied components and methods that have citrus-like aromas and promote oxytocin secretion. As a result, they discovered an oxytocin secretion-promoting effect in the essential oil extracted from the peel of the stinky orange, which has been consumed before, thus completing the present invention.

[0024] That is, the present invention includes the following.

[0025] (1) An application of stinky orange essential oil in the manufacture of an oxytocin secretion promoter.

[0026] (2) According to the application described in (1) above, the characteristic is that the above-mentioned stinky orange essential oil is obtained from the peel of the stinky orange by pressing or extraction.

[0027] (3) According to the application described in (1) or (2) above, the oxytocin secretion promoter is characterized in that it is ingested through the sense of smell and produces an oxytocin secretion promoting effect on the ingestor.

[0028] (4) A fragrance composition, which is an oxytocin secretion promoting fragrance composition containing an oxytocin secretion promoter, wherein the oxytocin secretion promoter includes stinky orange essential oil.

[0029] (5) A fragrance product containing an oxytocin secretion promoter or the oxytocin secretion promoting fragrance composition described in (4) above, wherein the oxytocin secretion promoter contains stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

[0030] (6) An oral composition comprising an oxytocin secretion promoter as described in (1) or (2) above or an oxytocin secretion promoter flavoring composition as described in (4) above, wherein the oxytocin secretion promoter comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

[0031] (7) The use of stinky orange essential oil in the manufacture of a skin improver.

[0032] (8) According to the application described in (7) above, the characteristic is that the above-mentioned stinky orange essential oil is obtained from the peel of the stinky orange by pressing or extraction.

[0033] (9) The application according to (7) or (8) above is characterized in that the skin improver is ingested through the sense of smell and produces a skin improver effect on the ingestor.

[0034] (10) The application according to (7) or (8) above is characterized in that the beneficial effect on the skin is selected from one or more of the following: preventing or improving the appearance of skin pores, improving skin laxity, and improving dry skin.

[0035] (11) A fragrance composition, which is a fragrance composition for skin improvement containing a skin improver, wherein the skin improver contains stinky orange essential oil.

[0036] (12) A fragrance product containing a skin improver or a fragrance composition for a skin improver as described in (11) above, wherein the skin improver contains stinky orange essential oil or stinky orange essential oil obtained from the peel of a stinky orange by pressing or extraction.

[0037] (13) An oral composition comprising a skin improver or a fragrance composition for skin improver as described in (11) above, wherein the skin improver comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

[0038] (14) An application of stinky orange essential oil in the manufacture of a multi-faceted mood improver.

[0039] (15) According to the application described in (14) above, the characteristic is that the above-mentioned stinky orange essential oil is obtained from the peel of the stinky orange by pressing or extraction.

[0040] (16) According to the application described in (14) or (15) above, the multi-emotional improver is characterized in that it produces a multi-emotional improvement effect on the user through olfactory intake.

[0041] (17) The application described in (14) or (15) above is characterized in that the multi-faceted mood improvement effect is the reduction of fatigue and / or the improvement of positive mood.

[0042] (18) A fragrance composition, which is a fragrance composition for a multi-emotional improver containing a multi-emotional improver, wherein the multi-emotional improver includes stinky orange essential oil.

[0043] (19) A fragrance product containing a fragrance composition of a multi-emotional improver or the multi-emotional improver described above (18), wherein the multi-emotional improver contains stinky orange essential oil or contains stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

[0044] (20) An oral composition comprising a multi-emotional improver or a flavoring composition of the multi-emotional improver described above (18), wherein the multi-emotional improver comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

[0045] The oxytocin secretion promoter of this invention uses natural stinky orange essential oil, which can be safely ingested through inhalation or oral administration. To improve various emotional states such as fatigue and mood, as well as skin conditions such as sagging skin, enlarged pores, and dry skin, it can be added to various inhalable or orally ingestible compositions, such as fragrance compositions, cosmetics, or oral compositions. In particular, the stinky orange essential oil used in this invention has a citrus-like fragrance that is popular in Japan, making it suitable for use in fragrance compositions and cosmetics. Attached Figure Description

[0046] Figure 1 It is a questionnaire used for subjective evaluation of multiple emotions and moods (a shortened version of the Multifaceted Emotional Scale (MMS) with 40 questions). Detailed Implementation

[0047] [1] Oxytocin secretion promoters

[0048] (1) Active ingredients

[0049] The oxytocin secretion promoter of the present invention contains stinky orange essential oil as an active ingredient.

[0050] The sphaerocarpa, a member of the Rutaceae family and the Citrus genus, is a sweet and sour citrus fruit (used as a condiment and flavoring citrus) that is a specialty of Oita Prefecture, Japan, characterized by its mellow and mild sour taste and refreshing aroma.

[0051] The stinky orange essential oil used in this invention is mainly obtained from the peel of the stinky orange, and can be obtained by pressing or steam distillation (for details, refer to the Japanese Patent Office Gazette "Collection of Commonly Used Techniques (Fragrances) Part I: General Fragrances", published on January 14, 2000, Japan Patent Office). It should be noted that the method of obtaining stinky orange essential oil is not limited to the methods described above.

[0052] (2) Promote oxytocin secretion

[0053] In this invention, "promoting oxytocin secretion" refers to promoting the secretion of oxytocin produced by oxytocin-producing tissues such as the hypothalamus. In other words, "promoting oxytocin secretion" in this invention means increasing the amount of oxytocin secreted in the blood and saliva, and enhancing the effect of oxytocin in various tissues, by promoting oxytocin production.

[0054] (3) Methods of taking oxytocin secretion promoters

[0055] The method of taking the oxytocin secretion promoter of the present invention is not particularly limited as long as the osmidr orange essential oil, which is the effective component of the oxytocin secretion promoter, is inhaled through the nostrils, or ingested in the mouth or absorbed through the skin.

[0056] Specifically, in addition to methods that artificially disperse fragrances into the space through diffusers, atomizers (diffusers and atomizers that utilize steam or ultrasound), aromatherapy candles, and other means of inhaling fragrances primarily through the nostrils, methods that involve inhaling naturally volatile fragrances from cosmetics used on clothing, skin, hair, or oral compositions, primarily beverages and foods.

[0057] When using an ultrasonic diffuser, add approximately 0.05–0.15% (about 2–3 drops per 100ml of water) of stinky orange essential oil relative to the amount of water in the container. During active periods, place it on a stable surface or floor in main activity areas such as the entryway, lounge, living room, office, and kitchen. When sleeping, place it near your feet or pillow so that the vapor and aroma of the essential oil are sprayed together.

[0058] [2] Skin improvers

[0059] The oxytocin secretion promoter of the present invention can be used as a skin improver. In the present invention, skin improvement refers to improving skin problems such as skin laxity, enlarged pores, and dry skin.

[0060] The skin improver of the present invention can be taken in the same way as the oxytocin secretion promoter described above.

[0061] [3] Multi-faceted mood improvers

[0062] The oxytocin secretion promoter of the present invention can be used as a mood improver in many ways.

[0063] In this invention, multi-faceted emotions refer to classifying emotions into eight emotional states: three scales representing positive emotions (active pleasure, inactive pleasure, and amicability), three scales representing negative emotions (depression / anxiety, burnout, and hostility), and two scales representing neutral emotions (surprise and focus).

[0064] Furthermore, in this invention, the improvement of multiple emotions refers to the improvement of one or more of the above eight emotional states. Additionally, in this invention, the reduction of fatigue refers to the improvement of fatigue among the above eight emotional states, and the enhancement of positive mood refers to the improvement of activity and pleasure among the above eight emotional states.

[0065] By quantifying the emotional changes induced by smelling fragrances as a multi-faceted emotional scale, it becomes possible to determine the improvement in various emotional states caused by fragrances.

[0066] The multi-faceted mood improver of the present invention can be taken in the same way as the oxytocin secretion promoter described above.

[0067] [4] Fragrance composition

[0068] The oxytocin secretion promoter of the present invention can be added alone to cosmetics, beverages and foods, or it can be used as a flavoring composition in combination with other flavoring materials.

[0069] As other flavoring materials, both natural and synthetic flavorings can be widely used. Examples include the flavorings listed in the Japan Patent Office Gazette “Collection of Commonly Used Techniques (Flavors) Part II: Flavorings for Food” (issued on January 14, 2000, Japan Patent Office) and “Collection of Commonly Used Techniques (Flavors) Part III: Flavorings for Cosmetics” (issued in June, 2001, Japan Patent Office).

[0070] When used in a fragrance composition, the content of the oxytocin secretion promoter in the composition is preferably in the range of 0.0001 to 90% by mass.

[0071] The oxytocin secretion promoter of the present invention can be added directly or as a fragrance composition in combination with other fragrance materials, and can be dissolved in solvents such as ethanol, propylene glycol, glycerol, and medium-chain triglycerides (MCT) as needed to be added to various cosmetics, beverages and foods.

[0072] Furthermore, commonly used emulsifiers and excipients can be added, and the product can be formulated using conventional methods to be used as emulsified fragrance or powdered fragrance.

[0073] The oxytocin secretion promoter of the present invention can be appropriately combined with various additives commonly used in cosmetics, beverages and foods, such as antioxidants, sugars, colorants, emulsifiers, preservatives, flavoring agents, sweeteners, colorants, and pH adjusters, as additional ingredients as needed.

[0074] [5] Fragrance cosmetics

[0075] Examples of fragrance-related cosmetics include perfumes (fragrances, eau de toilette, colognes, etc.), skincare cosmetics (toners, lotions, creams, lipsticks, foundations, facial cleansers, soaps, shower gels, body care products, bath salts, antiperspirants, deodorants, etc.), haircare cosmetics (shampoos, conditioners, hair masks, hair repair products, hair oils, hair nourishing agents, hair growth products, hair dyes, styling products, perming products, etc.), laundry detergents, fabric softeners, fabric finishing agents, various cleaning agents (for fibers, leather, hard surfaces, residential, household, toilet, and bathroom use, etc.), aromatic deodorizers, scented toilet paper, waxes, essential oils, and other household products.

[0076] When used in cosmetics, the content of oxytocin secretion promoter in the cosmetics is preferably 0.0001% or more. Oxytocin secretion promoter can also be used directly as essential oils, etc.

[0077] [6] Oral composition

[0078] Examples of oral compositions include beverages, snacks, processed foods, dairy products, flavorings, powdered beverages, powdered soups and other processed foods, oral hygiene products, nutritional supplements, and more specifically, the following substances.

[0079] Examples of beverages include soft drinks, lactic acid bacteria drinks, dairy drinks, non-fruit juice drinks, fruit juice drinks, carbonated drinks, alcoholic beverages, and nutritional drinks.

[0080] Examples of desserts include jelly, Bavarian pudding, mousse, cake, candy, biscuits, cookies, chocolate, chewing gum, soda, compressed candy, ice cream, sorbet, and popsicles.

[0081] Examples of processed foods include mayonnaise, sauces, Japanese dipping sauces, barbecue sauces, snacks (potato chips, fried rice crackers, hanrin candy, donuts), and cooked frozen foods (noodles, etc.).

[0082] Examples of dairy products include ice cream and yogurt.

[0083] Examples of oral hygiene products include toothpaste, mouthwash, mouthwash, oral cooling agents, and halitosis prevention agents.

[0084] Nutritional supplements can also be in the form of capsules, tablets, powders, syrups, or liquid suspensions.

[0085] When used in an oral composition, the content of the oxytocin secretion promoter in the composition is preferably in the range of 0.000001 to 0.1% by mass.

[0086] The present invention will now be described in detail with reference to the following examples, but the present invention is not limited to the following examples.

[0087] Example

[0088] [Experimental Example]

[0089] Evaluation of the skin-improving and multifaceted mood-enhancing effects of using stinky orange oil

[0090] [Experiment Summary]

[0091] (1) Test samples used in the experiment

[0092] The stinky orange essential oil I purchased is from Ogawa Spices & Oita Saeki Farm Co., Ltd. This product is an essential oil extracted from the peel of stinky oranges grown in Oita Prefecture using steam distillation.

[0093] Ion-exchanged water was used as a control. Test sample 1 and test sample 2 used in the experiment are shown in Table 1.

[0094] Table 1

[0095] Table 1: Types of Test Specimens

[0096] type content Test sample 1 Stink Orange Essential Oil Test sample 2 Ion-exchanged water

[0097] (2) Test methods

[0098] (a) Subjects

[0099] Twenty-four women aged 30 to 45 who reported dry or inelastic skin and experienced moderate stress were selected as subjects and divided into Group 1 and Group 2.

[0100] (b) Test content

[0101] Add 3 drops (0.1 ml) of the test sample to a container containing 100 ml of tap water in an ultrasonic atomizing diffuser, and place the diffuser within 1 m of the pillow and above the pillow.

[0102] The diffuser was run for a total of 3 hours, from 1 hour before bedtime to 2 hours after bedtime, allowing subjects to inhale the sprayed water mist through natural breathing. This continued for 4 weeks.

[0103] The experiment was set up as a parallel intergroup comparison test between Group 1 and Group 2. Group 1 inhaled test sample 1 for four weeks, and Group 2 inhaled test sample 2 for four weeks.

[0104] The skin improvement effect was evaluated using a skin survey questionnaire.

[0105] The skin survey questionnaire was conducted according to the criteria shown in Table 2 below.

[0106] Table 2

[0107] Table 2: Evaluation Criteria for Various Items in the Skin Survey Questionnaire

[0108] 1 point 2 points 3 points 4 points relaxation not much Slightly more many a lot of pores Not obvious Slightly obvious obvious It is obvious dry Not drying Slightly dry dry Very dry Moist Not moist Slightly moist Moist Very moist

[0109] In addition, subjective evaluations of various emotions and moods were conducted using a 40-question, shortened version of the Multifaceted Emotional State Scale (MMS). In this questionnaire, items were randomly arranged into eight scales: “Depression / Anxiety,” “Hospitality,” “Fatigue,” “Active Pleasure,” “Inactive Pleasure,” “Affinity,” “Focus,” and “Surprise.” For each term, the degree to which it matched the prevailing emotion was rated on a 4-point scale (1 point for “Completely Unfelt” to 4 points for “Clearly Felt”) (Terasaki et al., “The Creation of a Shortened Version of the Multifaceted Emotional State Scale,” Proceedings of the 55th Congress of the Japanese Psychological Society, 1991, 435).

[0110] The actual questionnaire paper used is as follows Figure 1 As shown.

[0111] [Experimental Example 1] Changes in oxytocin concentration in saliva

[0112] The oxytocin-promoting effect of stinky orange essential oil was investigated using test samples 1 and 2. Saliva was collected using Cryovial (SalivaBio) and Saliva Collection Aid (SalivaBio). After collection, saliva was rapidly frozen at -30°C or below. For analysis, the supernatant was recovered after centrifugation (3000 rpm, 4°C, 15 min). The concentration of oxytocin in saliva was determined using an Oxytocin ELISA kit (ENZO), following the kit's instructions. For test samples 1 and 2, the change in oxytocin levels before and after the experiment was calculated. Table 3 shows the oxytocin concentrations (mean ± standard error) in saliva before and after each experimental period for ion-exchanged water and stinky orange essential oil.

[0113] Table 3

[0114] Table 3: Changes in oxytocin concentration in saliva

[0115]

[0116] For ion-exchanged water, the concentration of oxytocin in saliva increased slightly after the test, but for stinky orange essential oil, the concentration of oxytocin in saliva increased significantly.

[0117] Based on these results, it can be confirmed that stinky orange essential oil has an oxytocin-promoting effect.

[0118] [Experimental Example 2] Changes in the evaluation value of skin laxity

[0119] Experiments 1 and 2 were used to study the inhibitory effect of stinky orange essential oil on skin laxity.

[0120] For test samples 1 and 2, the changes in skin laxity before and after the test were calculated. Table 4 shows the skin laxity evaluation (mean ± standard error) before and after each test period for ion-exchanged water and stinky orange essential oil.

[0121] Table 4

[0122] Table 4: Changes in skin laxity evaluation values

[0123]

[0124] For ion-exchanged water, the relaxation fraction increased slightly after the test, while for stinky orange essential oil, the relaxation fraction decreased.

[0125] Based on these results, it can be confirmed that stinky orange essential oil has the effect of improving skin laxity.

[0126] [Experimental Example 3] Change in the apparent value of skin pores

[0127] Using test samples 1 and 2, the effect of stinky orange essential oil on significantly improving pores was studied.

[0128] For test samples 1 and 2, the changes in pore visibility evaluation before and after the test were calculated. Table 5 shows the pore visibility evaluation (mean ± standard error) before and after each test period for ion-exchanged water and stinky orange essential oil.

[0129] Table 5

[0130] Table 5: Changes in the evaluation of visible pores on the skin

[0131]

[0132] For ion-exchanged water, the pore fraction decreased slightly after the test, but for stinky orange essential oil, the pore fraction decreased significantly.

[0133] Based on these results, it can be confirmed that stinky orange essential oil has the effect of improving pores.

[0134] [Experimental Example 4] Changes in skin dryness and moisture ratings

[0135] Experiments 1 and 2 were used to study the effects of stinky orange essential oil on dry skin.

[0136] The changes in skin dryness and moisture levels before and after each test were measured in test samples 1 and 2. Statistical significance was assessed using t-tests. Table 6 shows the skin dryness and moisture levels (mean ± standard error) before and after each test period for ion-exchanged water and stinky orange essential oil. Table 7 shows the skin moisture levels (mean ± standard error) before and after each test period for ion-exchanged water and stinky orange essential oil.

[0137] Table 6

[0138] Table 6: Changes in Skin Dryness Assessment Values

[0139]

[0140] Table 7

[0141] Table 7: Changes in skin moisture assessment values

[0142]

[0143] For ion-exchanged water, the dry fraction decreased slightly after the test period, but for stinky orange essential oil, the dry fraction decreased significantly (p < 0.05).

[0144] In addition, the wetting fraction increased slightly for ion-exchanged water after the test, but increased significantly for stinky orange essential oil (p < 0.05).

[0145] Based on the above results, it can be confirmed that stinky orange essential oil has an improving effect on dry skin.

[0146] [Experimental Example 5] Changes in multiple emotional scales

[0147] Using a multifaceted mood scale, mood states were rated on a 4-point scale (1-4) at the same time as the skin survey questionnaire. For each mood state score, the values ​​at week 0 and week 4 were calculated (mean ± standard error). Table 8 shows the "fatigue" scores (mean ± standard error) before and after each experimental period for ionized water and stinky orange essential oil, and Table 9 shows the "activity and pleasure" scores (mean ± standard error) before and after each experimental period for ionized water and stinky orange essential oil.

[0148] Table 8

[0149] Table 8: Changes in burnout ratings

[0150]

[0151] Table 9

[0152] Table 9: Changes in Activity-Based Pleasure Ratings

[0153]

[0154] Inhalation of stinky orange essential oil significantly reduced fatigue scores (p < 0.05).

[0155] In addition, the activity-related pleasure score increased significantly after inhalation of stinky orange essential oil (p < 0.05).

[0156] Based on the above results, it can be confirmed that stinky orange essential oil has the effect of reducing fatigue and increasing activity and pleasure, i.e., positive mood.

[0157] [Manufacturing Example]

[0158] Manufacturing of various compositions containing stinky orange essential oil

[0159] [Manufacturing Example 1]

[0160] The manufacture of bath oils containing stinky orange essential oil

[0161] Weigh the specified amounts of each component shown in phase A of Table 10 into a beaker and heat to 60°C in a constant-temperature water bath. Separately, weigh the specified amounts of each component shown in phase B of Table 10 into a beaker and dissolve them uniformly at room temperature using a spatula. Add phase B to phase A, dissolve uniformly using a spatula, and cool to room temperature.

[0162] The resulting bath oil has a refreshing citrus scent and provides a pleasant user experience.

[0163] Table 10

[0164] Table 10: Ingredients and Proportions of Bath Oils

[0165]

[0166] [Manufacturing Example 2]

[0167] The manufacture of mouthwash containing stinky orange essential oil

[0168] Weigh the specified amounts of each component shown in phase A and phase B of Table 11 into separate beakers and mix them using a spatula. Then, slowly add phase B to phase A and mix using a spatula.

[0169] The resulting mouthwash had a refreshing citrus scent and provided a pleasant user experience.

[0170] Table 11

[0171] Table 11: Raw materials and proportions of mouthwash agents

[0172]

[0173] Industrial availability

[0174] The oxytocin secretion promoter of the present invention uses natural stinky orange essential oil, which can be safely ingested by inhalation or oral administration. Therefore, it is expected to be applied in various compositions to improve various aspects of emotions such as reducing fatigue and improving positive mood, as well as skin conditions such as skin laxity, visible pores, and dry skin, such as fragrance compositions, cosmetics, or oral compositions.

Claims

1. An application of stinky orange essential oil in the manufacture of an oxytocin secretion promoter.

2. The application according to claim 1, characterized in that, The essential oil for the stinky orange is obtained from the peel of the stinky orange by pressing or extraction.

3. The application according to claim 1 or 2, characterized in that, The oxytocin secretion promoter is ingested through the sense of smell and produces an oxytocin secretion-promoting effect on the ingestor.

4. A fragrance composition, which is an oxytocin secretion promoting fragrance composition containing an oxytocin secretion promoter, said oxytocin secretion promoter comprising stinky orange essential oil.

5. A fragrance product containing an oxytocin secretion promoter or the oxytocin secretion promoting fragrance composition of claim 4, wherein the oxytocin secretion promoter comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

6. An oral composition comprising an oxytocin secretion promoter or the oxytocin secretion promoting flavoring composition of claim 4, wherein the oxytocin secretion promoter comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

7. The application of stinky orange essential oil in the manufacture of a skin improver.

8. The application according to claim 7, characterized in that, The essential oil for the stinky orange is obtained from the peel of the stinky orange by pressing or extraction.

9. The application according to claim 7 or 8, characterized in that, The skin improver is ingested through the sense of smell and produces a skin-improving effect on the user.

10. The application according to claim 7 or 8, characterized in that, The beneficial effects on the skin are selected from one or more of the following: preventing or improving the appearance of pores, improving skin laxity, and improving dry skin.

11. A fragrance composition, which is a fragrance composition for skin improvers containing a skin improver comprising stinky orange essential oil.

12. A fragrance product containing a skin improver or a fragrance composition for a skin improver as described in claim 11, wherein the skin improver comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of a stinky orange by pressing or extraction.

13. An oral composition comprising a skin improver or a fragrance composition for skin improver as described in claim 11, wherein the skin improver comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

14. An application of stinky orange essential oil in the manufacture of a multi-faceted mood improver.

15. The application according to claim 14, characterized in that, The essential oil for the stinky orange is obtained from the peel of the stinky orange by pressing or extraction.

16. The application according to claim 14 or 15, characterized in that, The aforementioned multi-faceted mood improver is ingested through the sense of smell and produces multi-faceted mood-improving effects on the user.

17. The application according to claim 14 or 15, characterized in that, The multifaceted effect of improving mood includes a reduction in fatigue and / or an increase in positive mood.

18. A fragrance composition comprising a multi-emotional modifier containing a multi-emotional modifier including stinky orange essential oil.

19. A fragrance product containing a multi-faceted mood improver or a fragrance composition of the multi-faceted mood improver as described in claim 18, wherein the multi-faceted mood improver comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

20. An oral composition comprising a multi-faceted mood improver or a flavoring composition of the multi-faceted mood improver of claim 18, wherein the multi-faceted mood improver comprises stinky orange essential oil or stinky orange essential oil obtained from the peel of stinky orange by pressing or extraction.

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