Intelligent responsive biomaterials for chronic wound repair and formulations thereof
By constructing layered structures through biomedical additive manufacturing processes and utilizing thermosensitive phase transition technology to achieve functionally zoned release of active molecules, the problem of temporal regulation of functional components in existing technologies has been solved, realizing the precision and functional matching of wound repair materials.
CN121490121BActive Publication Date: 2026-06-09SHANDONG ZHIFANG BIOTECHNOLOGY CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG ZHIFANG BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-12-08
- Publication Date
- 2026-06-09
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Figure CN121490121B_ABST
Abstract
The application relates to the field of biological medical material manufacturing, and discloses an intelligent responsive biomaterial for chronic wound repair and a preparation thereof. The preparation has early response layer and late repair layer function partition materials, and is prepared through a biological medical additive manufacturing method. The method uses an intelligent responsive recombinant multi-domain protein containing an elastin-like region as a temperature-sensitive biomaterial ink component, sets the printing nozzle temperature to be lower than the phase transition temperature of the component and the substrate platform temperature to be higher than the phase transition temperature of the component, drives in-situ solidification of the temperature-sensitive phase transition of the biomaterial ink to form a partition, solves the time sequence disorder problem of functional release of active molecules in a homogeneous preparation, and guarantees the execution of early antibacterial and late repair functions.
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