Pressurizing ultrafiltration device for nephrology department

Abstract

The invention discloses a nephrology department pressurization ultrafiltration device which comprises a blood filter press used for conducting pressurization ultrafiltration on blood, two peristaltic pumps are arranged on the outer surface of the blood filter press, a semi-permeable membrane filter is arranged in the blood filter press, and an anti-blocking assembly is arranged in the semi-permeable membrane filter. Through the synergistic effect of the trapezoidal structure of the tubular semi-permeable membrane, the spiral flow guide design and flexible stirring, the blood is kept at a stable flow speed in the filtering process, the blood backflow capacity difference caused by blockage is avoided, the problem that concentrated metabolic waste is sucked back to a blood vessel again after ultrafiltration is completed is solved, and the filtering efficiency is improved. The residual quantity of metabolic wastes in the blood after ultrafiltration is reduced, and the filtering effect is improved.

Description

Technical Field

[0001] This invention relates to a pressurized ultrafiltration device for nephrology, specifically a pressurized ultrafiltration device for nephrology, belonging to the field of nephrology medical technology. Background Technology

[0002] Nephrology pressurized ultrafiltration is a blood purification technology for patients with renal insufficiency (such as uremia and acute kidney injury). The core of it is to remove excess water, metabolic waste (such as urea and creatinine) and medium and large molecular toxins from the blood through "extracorporeal circulation + pressurized filtration" while retaining beneficial components such as albumin, thus maintaining the patient's fluid balance and internal environment stability.

[0003] A search revealed Chinese patent CN115227894A, which discloses a pressurized ultrafiltration device for nephrology. This device utilizes the reversible piston movement of two piston discs within two inner chambers to continuously draw blood to a certain extent. During the blood draw, the ultrafiltration-treated blood is reintroduced into the body, achieving a closed-loop ultrafiltration process. While this patented product uses piston discs to filter blood, in ultrafiltration of patients with viscous blood, the high viscosity and metabolic waste content, coupled with slow blood flow, result in significant impurities remaining on one side of the ultrafiltration membrane. This leads to less blood returning to the body. The difference in blood return volume creates a pressure difference within the blood vessels, generating suction within the ultrafiltration device. Consequently, clean blood is easily and quickly drawn back into the blood vessels after ultrafiltration, while some concentrated metabolic waste is drawn back in, resulting in the ultrafiltration blood still containing some metabolic waste and affecting the overall ultrafiltration effect. Summary of the Invention

[0004] The purpose of this invention is to provide a pressurized ultrafiltration device for nephrology in order to solve the above-mentioned problems.

[0005] The present invention achieves the above-mentioned objective through the following technical solution: a nephrology pressurized ultrafiltration device, comprising a blood pressure filter for pressurizing and ultrafiltration of blood, wherein two peristaltic pumps are provided on the outer surface of the blood pressure filter, and a semi-permeable membrane filter is provided inside the blood pressure filter, wherein an anti-clogging component is provided inside the semi-permeable membrane filter;

[0006] The anti-clogging component mainly consists of a medical spiral guide wire and a flexible micro stirrer. The semi-permeable membrane filter contains multiple sets of tubular semi-permeable membranes. Each tubular semi-permeable membrane has a medical spiral guide wire on its inner wall and a flexible micro stirrer in the middle of the tubular semi-permeable membrane. When blood enters the multiple sets of tubular semi-permeable membranes, the medical spiral guide wire causes the blood to flow through in a "spiral flow". When the flexible micro stirrer is driven to rotate, it generates a vortex in the blood. The flexible micro stirrer causes the blood inside the tubular semi-permeable membrane to flow slightly, avoiding impurities from staying and adhering to the membrane surface for a long time and reducing impurity adhesion.

[0007] The flexible micro-stirrer mainly consists of a silicone filament bundle, a silicone filament assembly, a drive motor, a rotating rod, a first gear disk, a synchronous gear set, a second gear disk, and a rotating gear set. The drive motor is located at the top center of the semi-permeable membrane filter. The drive motor has a rotating rod at its actuating end. The bottom of the rotating rod has a first gear disk and a second gear disk from top to bottom. Multiple synchronous gear sets and rotating gear sets are equidistantly arranged on the outer periphery of the first gear disk and the second gear disk. Each synchronous gear set and rotating gear set corresponds to one tubular semi-permeable membrane.

[0008] Preferably, the multiple tubular semi-permeable membranes inside the flexible micro-stirrer are arranged in a ring around the center, the diameter of the tubular semi-permeable membranes gradually decreases from top to bottom, and the cross-section of the tubular semi-permeable membranes is arranged in a trapezoidal shape.

[0009] Preferably, the tubular semi-permeable membrane has a silicone fiber bundle in the middle, and the silicone fiber bundle has multiple silicone fiber groups arranged at equal intervals from top to bottom. The bottom middle of the synchronous gear group and the rotating gear group are fixedly connected to the top of the silicone fiber bundle.

[0010] Preferably, the silicone filament assembly consists of 10 silicone filaments.

[0011] Preferably, the first gear disk meshes with the synchronous gear set, the second gear disk meshes with the rotating gear disk, and the diameter of the first gear disk is larger than the diameter of the second gear disk.

[0012] Preferably, the two peristaltic pumps are respectively disposed at the upper and lower ends of the blood pressure filter, and the two peristaltic pumps are respectively connected to an inlet blood vessel and an outlet blood vessel. One end of the inlet blood vessel is connected to one side of the top of the semipermeable membrane filter, and one end of the outlet blood vessel is connected to the bottom of the semipermeable membrane filter.

[0013] Preferably, a waste liquid collection pipe is provided on one side of the semi-permeable membrane filter, one end of the waste liquid collection pipe is located inside the semi-permeable membrane filter and does not contact the tubular semi-permeable membrane, and the other end of the waste liquid collection pipe is connected to a waste liquid collection tank.

[0014] Preferably, the diameter of the medical spiral guide wire is <10μm, the wall thickness of the tubular semipermeable membrane is 10-15μm, the pore size of the tubular semipermeable membrane wall is between 0.001-0.01μm, and the pore size of the tubular semipermeable membrane wall is described as "asymmetric distribution".

[0015] The present invention has the following beneficial effects:

[0016] 1. The trapezoidal structure of the tubular semipermeable membrane, the spiral flow guiding design, and the synergistic effect of flexible stirring ensure that the blood maintains a stable flow rate during the filtration process, avoids poor blood backflow capacity due to blockage, reduces the problem of "concentrated metabolic waste being reabsorbed into the blood vessels" after ultrafiltration, reduces the amount of metabolic waste residue in the blood after ultrafiltration, and improves the filtration effect.

[0017] 2. The anti-clogging component consists of a medical spiral guide wire and a flexible micro-stirrer, forming a dual anti-clogging system of "active disturbance + passive flow guidance": the medical spiral guide wire causes the blood to flow through the tubular semi-permeable membrane to form a "spiral flow", generating a gentle shear force that can flush the inner wall of the membrane and prevent local accumulation of impurities; the flexible micro-stirrer generates eddies in the blood through the low-speed rotating silicone wire bundle and silicone wire group, causing the blood inside the membrane to flow slightly, preventing impurities from adhering to the membrane surface for a long time, and the shear force is <500dyn / cm², so it will not damage red blood cells;

[0018] 3. The tubular semipermeable membrane gradually decreases in diameter from top to bottom, simulating the gradient changes in human blood vessels. It uses the "fluid acceleration effect" to counteract the decrease in blood flow rate caused by viscosity and membrane resistance, and avoids stagnation and deposition at the outlet end.

[0019] 4. The device is equipped with a detachable filter bottle with multiple layers of folded non-woven fabric inside, which can pre-filter the blood entering the semi-permeable membrane filter; the filter bottle outlet is also equipped with a 0.5μm protective net, which can intercept even if a small amount of fiber falls off the filter material, preventing it from entering the subsequent pipeline and contaminating the blood, thus ensuring the purity of the blood.

[0020] 5. For blood with different viscosities, the device can be adapted to clinical needs by adjusting the inner diameter of the tubular semi-permeable membrane and the diameter of the medical spiral guide wire. Attached Figure Description

[0021] Figure 1 This is a three-dimensional view of the overall structure of a pressurized ultrafiltration device for nephrology proposed in this invention;

[0022] Figure 2 This is a three-dimensional view of the overall structure of a pressurized ultrafiltration device for nephrology proposed in this invention;

[0023] Figure 3 This is a three-dimensional structural view of a blood pressure filter for a nephrology pressurized ultrafiltration device proposed in this invention;

[0024] Figure 4 This is a three-dimensional view of the semi-permeable membrane filter structure of a pressurized ultrafiltration device for nephrology proposed in this invention;

[0025] Figure 5 This is a three-dimensional view of the anti-clogging component structure of a pressurized ultrafiltration device for nephrology proposed in this invention;

[0026] Figure 6 This is a schematic diagram of the anti-clogging component structure of a pressurized ultrafiltration device for nephrology proposed in this invention;

[0027] Figure 7 This is a three-dimensional view of the anti-clogging component structure of a pressurized ultrafiltration device for nephrology proposed in this invention;

[0028] Figure 8 This is a three-dimensional structural view of an anti-clogging component of a pressurized ultrafiltration device for nephrology proposed in this invention.

[0029] In the diagram: 1. Blood pressure filter; 2. Control panel; 3. Peristaltic pump; 4. Semi-permeable membrane filter; 401. Inlet tube; 402. Outlet tube; 403. Waste liquid collection tube; 404. Waste liquid collection tank; 5. Removable filter bottle; 6. Anti-clogging component; 601. Tubular semi-permeable membrane; 602. Medical spiral guide wire; 603. Flexible micro-stirrer; 7. Silicone fiber bundle; 701. Silicone fiber assembly; 8. Drive motor; 801. Rotating rod; 802. First gear disk; 803. Synchronous gear set; 804. Second gear disk; 805. Rotating gear set. Detailed Implementation

[0030] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0031] Example 1:

[0032] Reference Figure 1-8 A nephrology pressurized ultrafiltration device includes a blood pressure filter 1 for pressurized ultrafiltration of blood, two peristaltic pumps 3 on the outer surface of the blood pressure filter 1, a semi-permeable membrane filter 4 inside the blood pressure filter 1, and an anti-clogging component 6 inside the semi-permeable membrane filter 4.

[0033] The anti-clogging component 6 is mainly composed of a medical spiral guide wire 602 and a flexible micro stirrer 603. The semi-permeable membrane filter 4 is provided with multiple sets of tubular semi-permeable membranes 601. Each tubular semi-permeable membrane 601 has a medical spiral guide wire 602 on its inner wall and a flexible micro stirrer 603 in the middle of the tubular semi-permeable membrane 601. When blood enters the multiple sets of tubular semi-permeable membranes 601, the medical spiral guide wire 602 causes the blood to flow through and form a "spiral flow". When the flexible micro stirrer 603 is driven to rotate, it generates eddies in the blood. The flexible micro stirrer 603 drives the blood inside the tubular semi-permeable membrane 601 to flow slightly, avoiding impurities from staying and adhering on the membrane surface for a long time and reducing impurity adhesion.

[0034] The flexible micro-stirrer 603 is mainly composed of a silicone filament bundle 7, a silicone filament assembly 701, a drive motor 8, a rotating rod 801, a first gear disk 802, a synchronous gear set 803, a second gear disk 804, and a rotating gear set 805. The drive motor 8 is located at the top center of the semi-permeable membrane filter 4. The drive motor 8 has a rotating rod 801 at its actuating end. The bottom end of the rotating rod 801 has a first gear disk 802 and a second gear disk 804 from top to bottom. Multiple synchronous gear sets 803 and rotating gear sets 805 are equidistantly arranged on the outer periphery of the first gear disk 802 and the second gear disk 804. Each synchronous gear set 803 and rotating gear set 805 corresponds to a tubular semi-permeable membrane 601.

[0035] The first gear disk 802 meshes with the synchronous gear set 803, and the second gear disk 804 meshes with the rotating gear disk 805. The diameter of the first gear disk 802 is larger than the diameter of the second gear disk 804.

[0036] In this embodiment, it should be noted that when using the blood pressure filter 1 to perform blood pressure filtration and circulation on a patient in clinical practice, after moving the blood pressure filter 1 to the designated position using the casters at the bottom of the blood pressure filter 1, the inlet blood vessel 401, outlet blood vessel 402 and other equipment are assembled.

[0037] The patient's blood is drawn out through the peristaltic pump 3 and the inlet tube 401 and enters the semi-permeable membrane filter 4 inside the blood pressure filter 1 for pressure filtration.

[0038] When performing ultrafiltration on patients with viscous blood, the anti-clogging component 6 can be activated simultaneously with blood pressure filtration. The drive motor 8 drives the rotating rod 801 to rotate, and the first gear disk 802 and the second gear disk 804 located at the bottom of the rotating rod 801 rotate synchronously, thereby driving the synchronous gear set 803 and the rotating gear set 805 that mesh with it to rotate, so as to realize the rotation of the silicone filament bundles 7 inside the multiple tubular semi-permeable membranes 601.

[0039] The drive motor 8 is a micro-motor that rotates at a low speed (30-50 rpm), causing the silica filament bundles 7 and silica filament assembly 701 to generate a gentle "vortex" in the blood inside the tubular semi-permeable membrane 601. Considering that too many silica filaments might increase the flow resistance of blood within the tubular semi-permeable membrane 601 of the semi-permeable membrane filter 4, leading to a decrease in blood flow velocity, which would be detrimental to the filtration process, when the number of silica filament bundles 7 is 10, the increase in blood flow resistance has a smaller impact on the overall filtration effect, while effectively improving blood flow and reducing impurity deposition.

[0040] The vortex generated by the rotation will cause the blood inside the tubular semipermeable membrane 601 to flow slightly, preventing impurities from "staying and adhering for a long time" on the surface of the tubular semipermeable membrane 601, while not generating excessive shear force (<500dyn / cm², within the safe range), so as not to damage red blood cells; the surface of the silicone filament bundle 7 and the silicone filament group 701 is coated with "heparin" (anticoagulant treatment) to prevent itself from causing coagulation, and is highly flexible so that it will not collide or scratch the hollow fiber membrane during rotation.

[0041] Meanwhile, the medical spiral guide wire 602 set inside the tubular semipermeable membrane 601 creates a "spiral flow" when blood enters from the top of the tubular semipermeable membrane 601 and flows downwards. Compared with straight flow, the spiral flow can generate a stronger "shear force" (but is below the blood tolerance threshold, <800dyn / cm²), which can "wash" the inner wall of the membrane, reduce the adhesion of impurities, and make the blood more evenly distributed in the membrane, avoiding local accumulation.

[0042] Meanwhile, the cross-section of the tubular semipermeable membrane 601 is trapezoidal, meaning that the inner diameter of the tubular semipermeable membrane 601 is designed with a structure that is "coarse at the inlet and thin at the outlet," simulating the gradient diameter change of human blood vessels (such as the natural transition of arteries from thick to thin). The "fluid acceleration effect" generated by the gradual change in diameter offsets the velocity decay of blood due to viscosity and membrane resistance during the flow process, ensuring that the blood maintains a stable flow rate from the inlet to the outlet, and avoiding stagnation and deposition at the outlet end (a common location for dead flow in traditional filters).

[0043] The trapezoidal structure of the tubular semipermeable membrane 601, combined with the medical spiral guide wire 602 and the silicone wire bundle 7, allows blood to pass through the tubular semipermeable membrane 601 better and faster during blood pressure filtration of patients, and alleviates the problem of blood clogging the tubular semipermeable membrane 601, making the blood pressure filtration circulation smoother.

[0044] Example 2:

[0045] Unlike Example 1, referring to Figure 1-8This embodiment also has the following further features: multiple tubular semi-permeable membranes 601 inside the flexible micro-stirrer 603 are arranged in a ring around the center, the diameter of the tubular semi-permeable membranes 601 gradually decreases from top to bottom, and the cross-section of the tubular semi-permeable membranes 601 is arranged in a trapezoidal shape.

[0046] A tubular semi-permeable membrane 601 has a silicone filament bundle 7 in the middle. Multiple silicone filament groups 701 are arranged at equal intervals from top to bottom in the silicone filament bundle 7. The bottom middle of the synchronous gear group 803 and the rotating gear group 805 are fixedly connected to the top of the silicone filament bundle 7. The silicone filament group 701 is composed of 10 silicone filaments.

[0047] In this embodiment, it should be noted that the tubular semi-permeable membrane 601 is made of polyethersulfone (PES), which has strong thermal stability. The inner diameter can be precisely controlled through a "melt spinning + mold gradient" process to achieve a gradient that is wider at the top and narrower at the bottom. After molding, the membrane wall structure is stable and is not prone to pore deformation due to blood pressure during long-term use (4-8 hour treatment cycle). At the same time, the polyethersulfone membrane has excellent biocompatibility and strong surface hydrophilicity, which can reduce protein adhesion and reduce the basis for impurity deposition.

[0048] The surface of the medical spiral drainage wire 602 is coated with heparin (heparin molecules are fixed on the PEEK surface through chemical bonding). Heparin can inhibit the activity of coagulation factor Xa and prevent coagulation from occurring on the surface of the drainage wire (clinical tests have shown that the heparin coating can reduce the thrombosis rate on the surface of the drainage wire by more than 90%).

[0049] Different specifications of blood pressure filtration machines can be selected according to the different conditions of patients. For example, for patients with mild viscosity (hematocrit 40%-45%), a combination of a 200μm→160μm inner diameter tubular semipermeable membrane 601 and an internal 8μm diameter medical spiral guide wire 602 can be used.

[0050] For patients with severe viscous blood (hematocrit > 45%), a combination of a 220μm→150μm inner diameter tubular semipermeable membrane 601 and an internal 5μm diameter medical spiral guide wire 602 can be used (the larger inlet inner diameter reduces initial resistance, and the finer guide wire reduces flow obstruction) to ensure that different patients can obtain the best flow effect.

[0051] Example 3:

[0052] Reference Figure 1-8 Compared to Embodiment 1 and Embodiment 2, in this embodiment: two peristaltic pumps 3 are respectively installed at the upper and lower ends of the blood pressure filter 1. The two peristaltic pumps 3 are respectively connected to an inlet blood vessel 401 and an outlet blood vessel 402. One end of the inlet blood vessel 401 is connected to the top side of the semipermeable membrane filter 4, and one end of the outlet blood vessel 402 is connected to the bottom end of the semipermeable membrane filter 4.

[0053] A waste liquid collection tube 403 is provided on one side of the semipermeable membrane filter 4. One end of the waste liquid collection tube 403 is located inside the semipermeable membrane filter 4 and does not contact the tubular semipermeable membrane 601. The other end of the waste liquid collection tube 403 is connected to a waste liquid collection tank 404. The diameter of the medical spiral guide 602 filament is <10μm. The membrane wall thickness of the tubular semipermeable membrane 601 is 10-15μm. The micropore diameter of the membrane wall of the tubular semipermeable membrane 601 is between 0.001-0.01μm. The micropore diameter of the membrane wall of the tubular semipermeable membrane 601 is described as "asymmetric distribution".

[0054] In this embodiment, it should be noted that the micropore size of the tubular semipermeable membrane 601 is "asymmetrically distributed," that is, the pore size on the "blood side" (inner side) of the tubular semipermeable membrane 601 is slightly larger (e.g., 0.01 μm), and the pore size on the "ultrafiltrate side" (outer side) is slightly smaller (e.g., 0.005 μm), forming a "tight on the outside and loose on the inside" structure. The large pore size on the inner side can reduce the "accumulation resistance" of impurities on the membrane surface, while the small pore size on the outer side ensures the retention of large molecules (such as proteins). At the same time, the overall permeability is improved by 20%-30%. Even if there are a small amount of impurities, they can flow out with the blood through the large pore size on the inner side and are not easily blocked.

[0055] The top of the blood pressure filter 1 is equipped with a control panel, and a removable filter bottle 5 is located on one side of the peristaltic pump 3. The inner cavity volume of the removable filter bottle 5 is 5-10ml, which reduces the residence time of blood in the module. At the same time, the removable filter bottle 5 is made of medical-grade polycarbonate. The medical-grade polycarbonate material is transparent, making it easy to observe whether there is impurity accumulation or blood clotting. The internal cavity shape adopts a "conical transition + smooth inner wall" design - the blood inlet and outlet are in "straight-line convection" (the inlet is at one end, the outlet is at the other end, and the axis coincides), avoiding right angles or concavities (right angles are prone to forming eddies and dead spaces).

[0056] Meanwhile, the removable filter bottle 5 has multiple layers of folded non-woven fabric inside to pre-filter the blood entering the semi-permeable membrane filter 4. A "protective net with a pore size of 0.5μm" is set at the outlet end of the removable filter bottle 5. The net is made of stainless steel or nylon. Even if a small amount of fiber falls off the filter material, it will be intercepted by the protective net to prevent it from entering the subsequent pipeline.

[0057] Two peristaltic pumps 3 control the blood delivery in the inlet blood vessel 401 and the outlet blood vessel 402 respectively. With the high-efficiency filtration of the semi-permeable membrane filter 4, the ultrafiltered blood can be stably returned to the patient's body. Excess water, urea, creatinine and other metabolic wastes in the returned blood are effectively removed and collected in the waste liquid collection tank 404 through the waste liquid collection pipe 403 to maintain the patient's fluid balance and internal environment stability.

Claims

1. A nephrology pressurized ultrafiltration device, comprising a blood pressure filter for pressurized ultrafiltration of blood, characterized in that: The blood pressure filter is equipped with two peristaltic pumps on its outer surface and a semi-permeable membrane filter inside, which is equipped with an anti-clogging component. The anti-clogging component mainly consists of a medical spiral guide wire and a flexible micro stirrer. The semi-permeable membrane filter contains multiple sets of tubular semi-permeable membranes. Each tubular semi-permeable membrane has a medical spiral guide wire on its inner wall and a flexible micro stirrer in the middle of the tubular semi-permeable membrane. When blood enters the multiple sets of tubular semi-permeable membranes, the medical spiral guide wire causes the blood to flow through in a "spiral flow". When the flexible micro stirrer is driven to rotate, it generates a vortex in the blood. The flexible micro stirrer causes the blood inside the tubular semi-permeable membrane to flow slightly, avoiding impurities from staying and adhering to the membrane surface for a long time and reducing impurity adhesion. The flexible micro-stirrer mainly consists of a silicone filament bundle, a silicone filament assembly, a drive motor, a rotating rod, a first gear disk, a synchronous gear set, a second gear disk, and a rotating gear set. The drive motor is located at the top center of the semi-permeable membrane filter. The drive motor has a rotating rod at its actuating end. The bottom of the rotating rod has a first gear disk and a second gear disk from top to bottom. Multiple synchronous gear sets and rotating gear sets are equidistantly arranged on the outer periphery of the first gear disk and the second gear disk. Each synchronous gear set and rotating gear set corresponds to one tubular semi-permeable membrane.

2. The pressurized ultrafiltration device for nephrology according to claim 1, characterized in that: The flexible micro-stirrer contains multiple tubular semi-permeable membranes arranged in a ring around the center, with the diameter of the tubular semi-permeable membranes gradually decreasing from top to bottom, and the cross-section of the tubular semi-permeable membranes being trapezoidal.

3. The pressurized ultrafiltration device for nephrology according to claim 1, characterized in that: The tubular semi-permeable membrane has a silicone fiber bundle in the middle, and multiple silicone fiber groups are arranged at equal intervals from top to bottom. The bottom middle of the synchronous gear group and the rotating gear group are fixedly connected to the top of the silicone fiber bundle.

4. The pressurized ultrafiltration device for nephrology according to claim 1, characterized in that: The silicone filament assembly consists of 10 silicone filaments.

5. The pressurized ultrafiltration device for nephrology according to claim 1, characterized in that: The first gear disk meshes with the synchronous gear set, and the second gear disk meshes with the rotating gear disk. The diameter of the first gear disk is larger than the diameter of the second gear disk.

6. The pressurized ultrafiltration device for nephrology according to claim 5, characterized in that: Two peristaltic pumps are respectively installed at the upper and lower ends of the blood pressure filter. The two peristaltic pumps are respectively connected to an inlet blood vessel and an outlet blood vessel. One end of the inlet blood vessel is connected to the top side of the semipermeable membrane filter, and one end of the outlet blood vessel is connected to the bottom end of the semipermeable membrane filter.

7. A pressurized ultrafiltration device for nephrology according to claim 6, characterized in that: A waste liquid collection pipe is provided on one side of the semi-permeable membrane filter. One end of the waste liquid collection pipe is located inside the semi-permeable membrane filter and does not contact the tubular semi-permeable membrane. The other end of the waste liquid collection pipe is connected to a waste liquid collection tank.

8. A pressurized ultrafiltration device for nephrology according to claim 7, characterized in that: The diameter of the medical spiral guide wire is <10μm, the wall thickness of the tubular semipermeable membrane is 10-15μm, the pore size of the tubular semipermeable membrane wall is between 0.001-0.01μm, and the pore size of the tubular semipermeable membrane wall is described as "asymmetric distribution".

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