Experimental rat fixing device

Abstract

The invention relates to an experimental rat fixing device, which comprises a fixed bed main body, which is provided with an accommodating cavity with an upward opening and is used for supporting an anesthetized experimental rat; the positioning unit is used for positioning the head and four limbs of the experimental rat; the abdomen pressurizing system is used for applying pressure to the abdomen of the experimental rat so as to control the breathing amplitude of the experimental rat; the abdomen pressurizing system comprises a pressure adjusting unit, a pressure conduction unit and a breathing amplitude indicating unit; the pressure conduction unit is used for being attached to the trunk part right above the abdomen of the experimental rat and fluctuates up and down along with breathing of the experimental rat; the pressure adjusting unit is used for adjusting the upper limit of movement of the pressure conduction unit in the vertical direction, so that the pressure applied to the trunk part by the pressure conduction unit is adjusted; the breathing amplitude indicating unit is provided with a pointer and a distance dial gauge, and the pointer is connected with the pressure conduction unit and moves along the distance dial gauge along with fluctuation of the pressure conduction unit. According to the device, effective restraint and breathing control on the rat are achieved.

Description

Technical Field

[0001] This application relates to the field of medical device technology, specifically to a rat restraint device. Background Technology

[0002] Laboratory mice are one of the most commonly used experimental animals in scientific research, applied in many fields such as medicine, pharmacology, pathology, biology, and microbiology. When medical imaging procedures such as magnetic resonance imaging (MRI) are involved, laboratory mice need to be immobilized.

[0003] Current devices for restraining laboratory mice include simple restraint devices that use a plastic or resin body with sponge pads and Velcro to simply fix the rat; there are also stereotaxic devices (usually including ear rods and incisor rods) used in brain science research to precisely fix the rat's head, but this method lacks effective fixation of the torso, especially the abdomen; and there is also a method that uses a rigid plate pressed against the animal's torso, attempting to reduce respiratory movement through physical restriction. These methods are all connected by components such as a base, support, and straps to achieve physical restraint of the animal.

[0004] CN115568972A discloses a restraint device for laboratory mice. This device includes a fixing plate with multiple slidable fixing frame mechanisms on it. A baffle is fixedly mounted on the upper right side of the fixing plate. Each fixing frame mechanism includes two fixing frames, left and right. An arc-shaped plate is rotatably mounted inside each fixing frame. A pivot is positioned between the lower end of the arc-shaped plate and the lower end of the fixing frame, rotatably connecting the pivot to the arc-shaped plate and fixedly connecting the pivot to the fixing frame. This device can accommodate laboratory mice of different body lengths. The rotatable arc-shaped plate can compress the space of the laboratory mouse, restricting its movement and facilitating subsequent tightening with a constriction bar.

[0005] CN103892932A discloses a fixation device for magnetic resonance imaging (MRI) of laboratory mice and its usage method. The device includes a cylindrical tube body with a first opening at one end and a conical surface at the other end, with a second opening on the conical surface. The tube wall has a through hole, and a base is located at the bottom of the tube body. The top of the base has a concave surface, the outer wall of which fits the outer wall of the tube body, and the bottom of the base is flat. In use, the tail of anesthetized mice is held, and the mouse is placed upside down into the cylindrical tube body, with its mouth and nose inserted into the second opening of the conical surface and its tail outside the tube. The tube body with the mouse is then placed on the prepared base. After the MRI examination, the mouse is removed from the tube body and allowed to recover before being fed again.

[0006] The aforementioned fixation methods either lack effective means of fixing the abdomen, failing to suppress severe MRI artifacts caused by respiratory movements; or may excessively compress the thoracic and abdominal cavities, affecting the animal's normal breathing and blood circulation, violating animal welfare, and potentially introducing physiological disturbances that affect the reliability of experimental results. Summary of the Invention

[0007] The purpose of this application is to provide a fixation device that can effectively fix experimental rats and suppress abdominal respiratory movements of rats through a quantifiable and adjustable pressure method, thereby significantly reducing artifacts in MRI images.

[0008] To achieve the above objectives, this application provides a rat restraint device, comprising: The fixed bed body has an upward-facing receiving cavity for supporting anesthetized experimental rats, with the abdomen of the experimental rats facing the receiving cavity. A positioning unit is used for positioning the head and limbs of the experimental rat; An abdominal compression system is used to apply pressure to the abdomen of the experimental rats to control the respiratory amplitude of the experimental rats; The abdominal compression system includes a pressure regulating unit, a pressure transmitting unit, and a respiratory amplitude indicating unit; the pressure transmitting unit is used to fit against the torso part directly above the abdomen of the experimental rat and rises and falls with the breathing of the experimental rat. The pressure regulating unit is used to adjust the upper limit of the vertical movement of the pressure transmission unit, thereby adjusting the pressure applied to the torso by the pressure transmission unit; The breathing amplitude indicator unit is equipped with a pointer and a distance scale. The pointer is connected to the pressure transmission unit and moves along the distance scale as the pressure transmission unit fluctuates. The respiratory amplitude of the experimental rat is determined by the range of movement of the pointer.

[0009] Preferably, the pressure regulating unit includes a vertically arranged, length-adjustable regulating rod; The pressure transmission unit includes a pressure plate and a slide rod connected to the center of the pressure plate. The pressure plate is used to fit against the torso portion, and the slide rod is configured to slide along the adjustment rod. The abdominal compression system also includes a pressure sensor integrated into the pressure transmission unit and wirelessly connected to an external display device.

[0010] Preferably, the abdominal pressure device is connected to the main body of the fixation bed or to an animal MRI coil.

[0011] More preferably, the side of the adjusting rod is provided with an elastic snap-fit ​​member with an opening, the elastic snap-fit ​​member being used to snap onto the upper part of the animal nuclear magnetic resonance coil to achieve a detachable connection with the animal nuclear magnetic resonance coil; The lower end of the slide bar has an extension that extends toward the inside of the through hole of the animal nuclear magnetic resonance coil. The extension is connected to the center of the pressure plate, so that the pressure plate fits against the torso.

[0012] Preferably, the bottom of the fixed bed body is provided with a connector for establishing a detachable connection with the connecting parts on a commercially available animal nuclear magnetic resonance coil.

[0013] More preferably, the positioning unit includes a head positioning module, which includes a length-adjustable incisor bar and a pair of length-adjustable ear bars; The ear rod is located on both sides of the main body of the fixed bed, corresponding to the external auditory canal of the experimental rat, and its length can be adjusted to extend into the external auditory canal of the experimental rat. The incisor bar is horizontally positioned, with one end connected to the main body of the fixation bed and the other end facing the head of the experimental rat. Its length can be adjusted to the incisor of the experimental rat to fix the incisor of the experimental rat.

[0014] Preferably, the head positioning module further includes an anesthesia mask, which is configured to slide along the length of the main body of the fixed bed; The anesthetic mask is equipped with an anesthetic gas delivery pipe and an exhaust gas channel, and the other end of the anesthetic gas delivery pipe is used to connect to the anesthetic gas source.

[0015] More preferably, the fixation unit includes a limb positioning module, which includes a number of fixing slots respectively disposed on both sides of the fixation bed body corresponding to the number of limbs of the experimental rat, and the limbs of the experimental rat respectively extend into the fixing slots.

[0016] Preferably, each of the fixing slots is provided with a restraint member, which is used to pull the limbs toward and fix them below the midline of the experimental rat's body.

[0017] More preferably, the containment cavity is provided with a body temperature maintenance unit at least at the bottom for heating the containment cavity during the test to maintain the body temperature of the experimental rat.

[0018] The technical solution claimed in this application achieves the following beneficial effects: 1. The abdominal compression system used in the fixation device achieved quantifiable suppression of respiratory amplitude in experimental rats, reducing respiratory motion artifacts by more than 80% at the source, and greatly improving the signal-to-noise ratio and clarity of abdominal MRI images. Because the mechanical compression used is not rigid, the pressure is controllable and monitorable, avoiding the risk of excessive compression and ensuring animal safety and welfare. 2. Simultaneously, the head and limbs of the experimental rats were fixed, achieving effective restraint of the entire rat body and enabling comprehensive control of motion artifacts.

[0019] 3. The body temperature maintenance unit can continuously provide heat to the experimental rats during the scanning process, maintaining their core body temperature at around 37°C, preventing hypothermia caused by anesthesia, ensuring their physiological stability, and improving the reliability and reproducibility of experimental results while meeting the ethical requirements of animal experiments.

[0020] 4. The functions of fixation, pressurization, heating, and anesthesia are highly integrated into one unit, which simplifies the operation process, shortens the preparation time, and improves experimental efficiency. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings in the following description are only embodiments of this application. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the main structure of a fixed bed with a fixed unit.

[0023] Figure 2 A schematic diagram of a nuclear magnetic resonance coil for animal use.

[0024] Figure 3 This is a schematic diagram of the structure in which the abdominal compression system is installed on the main body of the fixed bed.

[0025] Figure 4 This is a schematic diagram of an abdominal pressure system that can be detachably connected to an animal magnetic resonance coil.

[0026] Figure 5 This is a schematic diagram of the abdominal compression system not connected to an animal MRI coil.

[0027] Figure 6 A schematic diagram showing the connection of the abdominal pressure system to an animal MRI coil.

[0028] Figure 7 This is a cross-sectional schematic diagram of the main body of the fixed bed.

[0029] Figure label: 1-Fixed bed body; 2-Animal MRI coil; 3-Connecting component; 4-Pressure regulating unit; 5-Pressure transmission unit; 6-Respiratory amplitude indicator unit; 7-Pointer; 8-Distance scale; 9-Adjusting rod; 10-Pressure plate; 11-Slide rod; 12-Connecting rod; 13-Elastic snap-fit ​​component; 14-Incision tooth rod; 15-Ear rod; 16-Anesthesia mask; 17-Slider; 18-Anesthesia gas delivery tube; 19-Fixing slot; 20-Binding component; 21-Heat-conducting medium. Detailed Implementation

[0030] To make the objectives, technical solutions, and beneficial effects of the embodiments in this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0031] This embodiment provides a rat restraint device, preferably a rat restraint device for MRI testing. Figure 1-7 As shown, the rat restraint device mainly consists of a restraint bed body 1, a positioning unit, and an abdominal pressure system. The entire rat restraint device is preferably made of MRI-compatible high-strength engineering plastics (such as polycarbonate or PEEK). The restraint bed body 1 has an upward-facing receiving cavity for supporting the anesthetized experimental rat. During testing, the rat's abdomen faces the receiving cavity, and the cross-section of the receiving cavity is preferably U-shaped. The bottom of the restraint bed body preferably has a connector for establishing a detachable connection with a pre-set connecting component 3 on a commercially available animal MRI coil 2. The positioning unit is used to position the head and limbs of the experimental rat, thereby achieving effective restraint of the entire experimental rat.

[0032] An abdominal pressure system is used to apply pressure to the abdomen of experimental rats to control their respiratory amplitude. The system includes a pressure adjustment unit 4, a pressure transmission unit 5, and a respiratory amplitude indicator unit 6. During testing, the pressure transmission unit 5 is positioned to conform to the upper part of the rat's torso above the abdomen and rises and falls with the rat's breathing. The pressure adjustment unit 4 adjusts the upper limit of the vertical movement of the pressure transmission unit 5, thereby regulating the pressure applied to the rat's torso above the abdomen. The respiratory amplitude indicator unit 6 has a pointer 7 and a distance scale 8. The pointer 7 is connected to the pressure transmission unit 5 via a connector and moves along the distance scale 8 as the pressure transmission unit 5 rises and falls. The distance the pointer 7 moves on the scale 8 is equal to the distance the pressure transmission unit 5 rises and falls. The tester can pre-measure and record the linear relationship between the distance the pressure transmission unit rises and falls and the respiratory amplitude of the experimental rat; therefore, the respiratory level of the experimental rat can be determined by the range of pointer movement.

[0033] In this embodiment, the head and limbs of the experimental rat are simultaneously immobilized, achieving effective restraint of the entire rat and enabling comprehensive control of motion artifacts. The abdominal compression system used in the immobilization device applies a uniform, controllable, and quantifiable pressure to the rat's abdomen by precisely controlling the downward displacement of the pressure transmission unit. This pressure is sufficient to gently restrict diaphragmatic movement and abdominal wall fluctuations (suppressing respiratory amplitude by 50%-70%), reducing respiratory motion artifacts by more than 80% at the source, and significantly improving the signal-to-noise ratio and clarity of the abdominal MRI images. Furthermore, because mechanical compression is used instead of rigid pressure, the pressure is controllable and monitorable, avoiding the risk of excessive compression and ensuring animal safety and welfare.

[0034] In one exemplary embodiment, the pressure regulating unit includes a vertically positioned, length-adjustable regulating rod 9. The regulating rod 9 can be configured as a threaded adjustment type, dividing the rod into two sections: one section machined with an external thread, and the other section machined as an internal thread sleeve. By rotating the two sections, the overall length is changed by the advance and retraction of the threads. A scale can also be provided on the external thread section, with an accuracy of, for example, 0.1 mm. Alternatively, the regulating rod can be configured as a plug-in type or a telescopic sleeve type, or any structure that enables length adjustment.

[0035] Exemplarily, the pressure transmission unit 4 may be configured to include a pressure plate 10 and a slide rod 11 connected to the center of the pressure plate 10, the slide rod 11 being configured to slide along the lower end of the adjusting rod 9. The pressure plate 10 is used to conform to the torso of the experimental rat, and the pressure plate 10 is preferably configured to be arc-shaped, the curvature of which is adapted to the torso directly above the abdomen of the experimental rat. The adjusting rod 9 may be sleeved on the slide rod 11, allowing the slide rod 11 to slide within it. The pointer 7 may be exemplaryly connected to the pressure plate 10 via a thin rod passing through the center of the adjusting rod 9 and the center of the slide rod 11, so as to move with the movement of the pressure plate 10; in another exemplary structure, the thin rod may also be configured to pass through the center of the adjusting rod 9 and be connected to the upper end of the slide rod 11.

[0036] In a preferred embodiment, the abdominal compression system also includes a flexible pressure sensor integrated inside the pressure plate 10 (not shown in the figure) for real-time measurement of the pressure applied to the experimental rat. The pressure sensor is wirelessly connected to an external display device, which can directly read the pressure value applied to the abdomen (unit: kPa or mmHg) in real time. This achieves closed-loop control of pressure and accurate recording of data, greatly improving the repeatability and scientific rigor of the experiment.

[0037] In the preferred embodiment, refer to Figure 4 In this embodiment, the abdominal compression device can be configured to be connected to the main body 1 of the fixed bed or to be detachably connected to the animal MRI coil 2. (Reference) Figure 2 When installed on the main body 1 of the fixation bed, the fixation device can also be used in a non-NMR testing environment, in the following exemplary manner: the abdominal pressure device (e.g., the adjustment rod therein) is connected to one side of the main body of the fixation bed via a vertical connecting rod 12, the connecting rod 12 having a first extension extending toward the center of the main body of the fixation bed, the first extension causing the pressure plate 10 in the pressure transmission unit to be located above the torso of the experimental rat corresponding to the abdomen.

[0038] When the abdominal compression device is configured to be detachably mounted on an animal MRI coil, an elastic snap-fit ​​element 13 with an opening can be provided, for example, on the side of the adjusting rod 9. Figure 5-6 As shown, the elastic snap-fit ​​13 is used to snap onto the upper part of the animal MRI coil 2 to achieve a detachable connection with the animal MRI coil. In this case, the lower end of the slide bar 11 is provided with a second extension extending toward the inside of the through hole of the animal MRI coil. This second extension is connected to the center of the pressure plate 10, so that the pressure plate 10 can fit against the torso of the experimental rat during the test.

[0039] In the preferred embodiment, refer to Figure 1The positioning unit in this embodiment includes a head positioning module, which comprises an incisor rod 14 whose length can be adjusted via a precision thread and a pair of ear rods 15 whose lengths can also be adjusted via precision threads. The ear rods 15 are respectively positioned on both sides of the fixation bed body corresponding to the external auditory canals of the experimental rat, and have tapered blunt tips. Their length can be adjusted to extend into the external auditory canal of the experimental rat to prevent head rotation and translation. The incisor rod 14 is horizontally positioned, with one end connected to the fixation bed body 1 and the other end facing the head of the experimental rat. It has a hook-like structure, and its length can be adjusted to the incisors of the experimental rat to fix the incisors. Together with the ear rods, it achieves precise three-dimensional positioning of the experimental rat's head. In this embodiment, the incisor rod and ear rods can be made of POM (polyoxymethylene). Their structure and connection to the fixation bed body can refer to existing technologies and will not be described in detail here.

[0040] In a more preferred embodiment, refer to Figure 1 The head positioning module also includes an anesthesia mask 16, which is configured to slide along both sides of the fixed bed body. For example, sliders 17 (or slide rails) can be provided on both sides of the anesthesia mask, and grooves for sliding the sliders 17 (or slide rails) can be provided on both sides of the fixed bed body. The anesthesia mask 16 is provided with an anesthetic gas delivery pipe 18 and a waste gas exhaust channel, and the other end of the anesthetic gas delivery pipe 18 is used to connect to the anesthetic gas source.

[0041] In another preferred embodiment, refer to Figure 1 The positioning unit also includes a limb positioning module, which comprises a number of fixing slots 19 on both sides of the main body 1 of the fixation bed, corresponding to the number of limbs of the experimental rat. During the test, the limbs of the anesthetized experimental rat are inserted into the fixing slots 19. Furthermore, each fixing slot is equipped with a restraint 20, which can be, for example, in the form of an abdominal binder, and can be made of medical-grade silicone or Velcro. The four restraints are used to further pull the limbs of the experimental rat towards and fix them below the midline of the experimental rat's body, further preventing MRI artifacts caused by limb movement.

[0042] In another preferred embodiment, the receiving cavity of the fixed bed body is provided with a body temperature maintenance unit at least at the bottom for heating the receiving cavity during testing to maintain the body temperature of the experimental rat at approximately 37°C, preventing hypothermia caused by anesthesia and ensuring the stability of the experimental rat's physiological state. In an exemplary structure, refer to Figure 7 The body temperature maintenance unit consists of a heat-conducting medium 21 and a heating element, which is connected to a power source. During MRI scans, the power source is set 1 to 2 meters away from the magnetic field to avoid interference with the MRI. The heat-conducting medium, which is water, is arranged in pipes around the entire containment cavity. The heating element is a non-metallic heating element such as ceramic or quartz tube.

[0043] The embodiments and application examples described above are merely illustrative descriptions of this application and are not intended to limit the scope of this application. Any modifications and improvements made to the technical solutions of this application by those skilled in the art without departing from the spirit of this application should fall within the protection scope defined by this application.

Claims

1. An experimental rat fixing device, characterized by, The utility model relates to a fixed bed main part, with the cavity of opening upward for supporting the experimental rat after anesthesia, the abdomen of experimental rat is towards the cavity, positioning unit for the positioning of the head and limbs of experimental rat, abdomen pressurization system for exerting pressure to the abdomen of experimental rat to control the respiratory amplitude of experimental rat, wherein, abdomen pressurization system includes pressure regulating unit, pressure transmission unit and respiratory amplitude indicating unit, pressure transmission unit is used for the torso part of the abdomen of experimental rat directly above and with the respiration of experimental rat and goes up and down fluctuation, pressure regulating unit is used for adjusting the upper limit of pressure transmission unit in vertical direction movement, thereby adjusting the pressure that pressure transmission unit exerts to the torso part, respiratory amplitude indicating unit is equipped with pointer and distance scale table, the pointer is connected pressure transmission unit and with the fluctuation of pressure transmission unit along distance scale table moves, the respiratory amplitude of experimental rat is judged through the moving range of pointer. The utility model relates to a fixed bed main part, with the cavity of opening upward for supporting the experimental rat after anesthesia, the abdomen of experimental rat is towards the cavity, positioning unit for the positioning of the head and limbs of experimental rat, abdomen pressurization system for exerting pressure to the abdomen of experimental rat to control the respiratory amplitude of experimental rat, wherein, abdomen pressurization system includes pressure regulating unit, pressure transmission unit and respiratory amplitude indicating unit, pressure transmission unit is used for the torso part of the abdomen of experimental rat directly above and with the respiration of experimental rat and goes up and down fluctuation, pressure regulating unit is used for adjusting the upper limit of pressure transmission unit in vertical direction movement, thereby adjusting the pressure that pressure transmission unit exerts to the torso part, respiratory amplitude indicating unit is equipped with pointer and distance scale table, the pointer is connected pressure transmission unit and with the fluctuation of pressure transmission unit along distance scale table moves, the respiratory amplitude of experimental rat is judged through the moving range of pointer. The utility model relates to a fixed bed main part, with the cavity of opening upward for supporting the experimental rat after anesthesia, the abdomen of experimental rat is towards the cavity, positioning unit for the positioning of the head and limbs of experimental rat, abdomen pressurization system for exerting pressure to the abdomen of experimental rat to control the respiratory amplitude of experimental rat, wherein, abdomen pressurization system includes pressure regulating unit, pressure transmission unit and respiratory amplitude indicating unit, pressure transmission unit is used for the torso part of the abdomen of experimental rat directly above and with the respiration of experimental rat and goes up and down fluctuation, pressure regulating unit is used for adjusting the upper limit of pressure transmission unit in vertical direction movement, thereby adjusting the pressure that pressure transmission unit exerts to the torso part, respiratory amplitude indicating unit is equipped with pointer and distance scale table, the pointer is connected pressure transmission unit and with the fluctuation of pressure transmission unit along distance scale table moves, the respiratory amplitude of experimental rat is judged through the moving range of pointer. The utility model relates to a fixed bed main part, with the cavity of opening upward for supporting the experimental rat after anesthesia, the abdomen of experimental rat is towards the cavity, positioning unit for the positioning of the head and limbs of experimental rat, abdomen pressurization system for exerting pressure to the abdomen of experimental rat to control the respiratory amplitude of experimental rat, wherein, abdomen pressurization system includes pressure regulating unit, pressure transmission unit and respiratory amplitude indicating unit, pressure transmission unit is used for the torso part of the abdomen of experimental rat directly above and with the respiration of experimental rat and goes up and down fluctuation, pressure regulating unit is used for adjusting the upper limit of pressure transmission unit in vertical direction movement, thereby adjusting the pressure that pressure transmission unit exerts to the torso part, respiratory amplitude indicating unit is equipped with pointer and distance scale table, the pointer is connected pressure transmission unit and with the fluctuation of pressure transmission unit along distance scale table moves, the respiratory amplitude of experimental rat is judged through the moving range of pointer. The utility model relates to a fixed bed main part, with the cavity of opening upward for supporting the experimental rat after anesthesia, the abdomen of experimental rat is towards the cavity, positioning unit for the positioning of the head and limbs of experimental rat, abdomen pressurization system for exerting pressure to the abdomen of experimental rat to control the respiratory amplitude of experimental rat, wherein, abdomen pressurization system includes pressure regulating unit, pressure transmission unit and respiratory amplitude indicating unit, pressure transmission unit is used for the torso part of the abdomen of experimental rat directly above and with the respiration of experimental rat and goes up and down fluctuation, pressure regulating unit is used for adjusting the upper limit of pressure transmission unit in vertical direction movement, thereby adjusting the pressure that pressure transmission unit exerts to the torso part, respiratory amplitude indicating unit is equipped with pointer and distance scale table, the pointer is connected pressure transmission unit and with the fluctuation of pressure transmission unit along distance scale table moves, the respiratory amplitude of experimental rat is judged through the moving range of pointer. The utility model relates to a fixed bed main part, with the cavity of opening upward for supporting the experimental rat after anesthesia, the abdomen of experimental rat is towards the cavity, positioning unit for the positioning of the head and limbs of experimental rat, abdomen pressurization system for exerting pressure to the abdomen of experimental rat to control the respiratory amplitude of experimental rat, wherein, abdomen pressurization system includes pressure regulating unit, pressure transmission unit and respiratory amplitude indicating unit, pressure transmission unit is used for the torso part of the abdomen of experimental rat directly above and with the respiration of experimental rat and goes up and down fluctuation, pressure regulating unit is used for adjusting the upper limit of pressure transmission unit in vertical direction movement, thereby adjusting the pressure that pressure transmission unit exerts to the torso part, respiratory amplitude indicating unit is equipped with pointer and distance scale table, the pointer is connected pressure transmission unit and with the fluctuation of pressure transmission unit along distance scale table moves, the respiratory amplitude of experimental rat is judged through the moving range of pointer. ​ ​ 2. The experimental rat immobilization device of claim 1, wherein, ​ ​ ​ 3. The experimental rat immobilization device of claim 2, wherein, ​ 4. The experimental rat immobilization device of claim 3, wherein, ​ ​ 5. The experimental rat immobilization device of claim 1, wherein, ​ 6. The experimental rat immobilization device of claim 1, wherein, ​ ​ ​ 7. The experimental rat immobilization device of claim 6, wherein, ​ ​ 8. The experimental rat immobilization device of claim 1, wherein, The positioning unit comprises a four-limb positioning module, which comprises a number of fixing slots corresponding to the four limbs of the experimental rat and arranged on both sides of the fixed bed body respectively, and the four limbs of the experimental rat respectively extend into the fixing slots.

9. The experimental rat immobilization device of claim 8, wherein, A binding member is arranged at each fixing slot, which is used to pull and fix the four limbs below the body midline of the experimental rat.

10. The experimental rat immobilization device of claim 1, wherein, The accommodating cavity is provided with a body temperature maintaining unit at least at the bottom, which is used to heat the accommodating cavity to maintain the body temperature of the experimental rat during the test.

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