Traditional Chinese medicine composition for treating joint diseases as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating joint diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 45 parts of radix angelicae pubescentis, 25 to 45 parts of cortex phellodendri, 20 to 40 parts of rhizoma smilacis glabrae, 20 to 40 parts of rhizoma dioscoreae septemlobae, 20 to 40 parts of rhizoma chuanxiong, 20 to 40 parts of semen coicis, 20 to 40 parts of radix cyathulae, 20 to 40 parts of herba artemisiae scopariae, 20 to 40 parts of herba lycopodii, 20 to 40 parts of rhizoma polygoni cuspidati, 20 to 40 parts of radix dipsaci, 20 to 40 parts of rhizoma atractylodis, 20 to 40 parts of semen plantaginis and 10 to 25 parts of liquorice root. The traditional Chinese medicine composition has a relatively good treatment effect on gout, rheumatic arthritis and rheumatoid arthritis, can treat both symptoms and root causes, and is relatively small in side effect and relatively small in harm to a human body.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating joint diseases, its preparation method, and its application. Background Technology

[0002] Gout is a heterogeneous group of diseases caused by purine metabolism disorders or uric acid excretion disorders. Clinical manifestations include elevated blood uric acid, recurrent acute arthritis, tophi, and joint deformities. It can also lead to uric acid kidney stones, glomerular, tubular, interstitial, and vascular kidney damage. Gouty arthritis is a disease caused by the deposition of urate crystals in tissues such as the synovium, joint capsule, cartilage, and bone, resulting in lesions and inflammatory reactions. It usually occurs in men over 40 years of age, most commonly affecting the first metatarsophalangeal joint. The main clinical manifestations are recurrent arthritis and hyperuricemia. In severe cases, tophi may appear, leading to joint deformities and functional impairment. Gouty arthritis is an important process in the pathogenesis of gout, and the two cannot be completely separated.

[0003] Currently, medications for gout or gouty arthritis mainly include drugs for treating damp-heat obstruction, drugs for promoting blood circulation and removing blood stasis, and chemical uric acid-lowering drugs. However, drugs for treating damp-heat obstruction focus on clearing heat and removing dampness, lacking synergistic intervention on rheumatic stagnation and liver and kidney deficiency; drugs for promoting blood circulation and removing blood stasis have limited effects on controlling inflammation in the acute phase and regulating the body's constitution; chemical uric acid-lowering drugs achieve the goal of lowering uric acid by inhibiting uric acid synthesis, but they have liver and kidney toxicity and are expensive. Therefore, it is particularly important to find a drug with definite efficacy and few side effects. Summary of the Invention

[0004] In view of the above-mentioned shortcomings in the prior art, the present invention provides a traditional Chinese medicine composition for treating joint diseases, its preparation method and application. The traditional Chinese medicine composition has good therapeutic effects on gout, rheumatoid arthritis and osteoarthritis, and can achieve both symptomatic and radical treatment. Moreover, the drug has few side effects and is less harmful to the human body.

[0005] To achieve the above objectives, the technical solution adopted by the present invention to solve its technical problem is as follows:

[0006] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: Angelica pubescens 25-45 parts, Phellodendron chinense 25-45 parts, Smilax glabra 20-40 parts, Dioscorea hypoglauca 20-40 parts, Ligusticum chuanxiong 20-40 parts, Coix lacryma-jobi 20-40 parts, Achyranthes bidentata 20-40 parts, Artemisia capillaris 20-40 parts, Lycopodium clavatum 20-40 parts, Polygonum cuspidatum 20-40 parts, Dipsacus asper 20-40 parts, Atractylodes lancea 20-40 parts, Plantago asiatica 20-40 parts, and Glycyrrhiza uralensis 10-25 parts.

[0007] Further, it includes the following components in parts by weight: 30-40 parts Angelica pubescens, 30-40 parts Phellodendron chinense, 25-35 parts Smilax glabra, 25-35 parts Dioscorea hypoglauca, 25-35 parts Ligusticum chuanxiong, 25-35 parts Coix lacryma-jobi, 25-35 parts Achyranthes bidentata, 25-35 parts Artemisia capillaris, 25-35 parts Lycopodium clavatum, 25-35 parts Polygonum cuspidatum, 25-35 parts Dipsacus asper, 25-35 parts Atractylodes lancea, 25-35 parts Plantago asiatica, and 15-20 parts Glycyrrhiza uralensis.

[0008] Further, it includes the following components in parts by weight: 30 parts Angelica pubescens, 40 parts Phellodendron chinense, 35 parts Smilax glabra, 25 parts Dioscorea hypoglauca, 35 parts Ligusticum chuanxiong, 25 parts Coix lacryma-jobi, 25 parts Achyranthes bidentata, 35 parts Artemisia capillaris, 35 parts Lycopodium clavatum, 25 parts Polygonum cuspidatum, 25 parts Dipsacus asper, 35 parts Atractylodes lancea, 25 parts Plantago asiatica, and 15 parts Glycyrrhiza uralensis.

[0009] Further, it includes the following components in parts by weight: Angelica pubescens 40 parts, Phellodendron chinense 30 parts, Smilax glabra 25 parts, Dioscorea hypoglauca 35 parts, Ligusticum chuanxiong 25 parts, Coix lacryma-jobi 35 parts, Achyranthes bidentata 35 parts, Artemisia capillaris 35 parts, Lycopodium clavatum 25 parts, Polygonum cuspidatum 35 parts, Dipsacus asper 35 parts, Atractylodes lancea 25 parts, Plantago asiatica 35 parts, and Glycyrrhiza uralensis 20 parts.

[0010] Further, it includes the following components in parts by weight: 36 parts Angelica pubescens, 36 parts Phellodendron chinense, 30 parts Smilax glabra, 30 parts Dioscorea hypoglauca, 30 parts Ligusticum chuanxiong, 30 parts Coix lacryma-jobi, 30 parts Achyranthes bidentata, 30 parts Artemisia capillaris, 30 parts Lycopodium clavatum, 30 parts Polygonum cuspidatum, 30 parts Dipsacus asper, 30 parts Atractylodes lancea, 30 parts Plantago asiatica, and 18 parts Glycyrrhiza uralensis.

[0011] Furthermore, the Job's tears are stir-fried Job's tears with wheat bran.

[0012] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: mixing the raw materials after pulverizing them; or preparing the composition by mixing or extracting the raw materials individually; or preparing the composition by further refining and purifying the extract to obtain the active ingredient; or preparing the composition by adding pharmaceutically acceptable excipients to the extract / active ingredient.

[0013] Furthermore, the dosage form produced is one of the following: pills, granules, capsules, powders, mixtures, tablets, granules, or oral liquids.

[0014] Further, the above fourteen ingredients are decocted with water, filtered, and the filtrates are combined and concentrated under reduced pressure to an extract with a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the extract is granulated to obtain the final product.

[0015] Furthermore, decoct three times. Add 10 times the amount of water for the first time, and 8 times the amount of water for the second and third times, and decoct for 1 hour each time.

[0016] Use of the above-mentioned traditional Chinese medicine composition for treating joint diseases in the preparation of a drug for treating joint diseases.

[0017] The beneficial effects produced by the present invention are as follows:

[0018] In the present invention, Herba Lycopodii is pungent, warm, dredging and promoting, capable of dispelling wind and dampness, relaxing muscles and tendons, assisting Herba Angelicae Pubescentis in dredging meridians, relieving joint stiffness and difficulty in flexion and extension, combining the functions of dispelling wind and dampness with relaxing muscles and tendons, and enhancing the analgesic effect; Dipsacus Root has the effects of tonifying the liver and kidney, strengthening muscles and bones. In view of the situation that arthralgia syndrome consumes the liver and kidney over time and the muscles and bones are not nourished, while dispelling wind and dampness, it also takes into account strengthening the healthy qi to prevent the long-term use of drugs for clearing and promoting from damaging the liver and kidney, reflecting the idea of treating arthralgia without forgetting to tonify the liver and kidney; Plantain Seed clears heat and promotes diuresis, percolates dampness and promotes diuresis, can dredge water passages, and guide damp heat and damp turbidity to be excreted from urine, strengthening the effects of Herba Artemisiae Scopariae and Rhizoma Dioscoreae Hypoglaucae in promoting diuresis and expelling turbid dampness, providing an outlet for damp pathogens; The above three are monarch drugs in combination, and their synergy lays the core direction of dehumidifying and strengthening muscles and bones;

[0019] Herba Artemisiae Scopariae is bitter and cold, clearing and promoting, belonging to the liver, gallbladder and spleen meridians, specializing in clearing damp heat, promoting diuresis and removing jaundice, capable of clearing the accumulated damp heat pathogens in the body, and at the same time promoting the excretion of damp turbidity from the lower jiao; Cortex Phellodendri is bitter and cold, descending and sinking, belonging to the kidney and bladder meridians, good at clearing dampness and heat, purging fire and detoxifying, especially clearing damp heat in the lower jiao. When combined with Herba Artemisiae Scopariae, it strengthens the power of clearing damp heat. For joint swelling, redness, heat and pain, it restrains the further damage of damp heat to tendons and meridians. Herba Angelicae Pubescentis is pungent, warm, bitter and drying, belonging to the kidney and bladder meridians, good at dispelling wind and dampness, dredging arthralgia and relieving pain, especially good at treating arthralgia pain in the waist, knees and lower limb joints, and can directly attack the superficial symptoms of wind-damp obstruction, relieving joint contracture pain; Rhizoma Smilacis Glabrae specializes in clearing heat and detoxifying, promoting diuresis and dredging collaterals, can assist Herba Artemisiae Scopariae and Cortex Phellodendri in clearing damp heat, and can also detoxify damp toxins, while dredging collaterals and relieving pain, suitable for joint swelling and pain caused by damp heat combined with toxins; Rhizoma Polygoni Cuspidati has the effects of clearing heat and detoxifying, promoting diuresis and removing jaundice, dissipating stasis and relieving pain, assisting Herba Artemisiae Scopariae and Cortex Phellodendri in clearing damp heat. Its stasis-dissipating function can resolve the stasis caused by long-term accumulation of damp heat, and at the same time its cold nature can enhance the power of clearing heat; Rhizoma Dioscoreae Hypoglaucae is good at promoting diuresis and removing turbid dampness, dispelling wind and relieving arthralgia, can specifically remove the damp turbidity between joints, and when combined with Herba Artemisiae Scopariae and Rhizoma Smilacis Glabrae, it strengthens the core of promoting diuresis and expelling turbid dampness, reducing the stimulation of damp turbidity to joints; The above are all ministerial drugs;

[0020] Chuanxiong is a qi-regulating drug in blood, capable of promoting blood circulation and qi movement, dispelling wind and relieving pain. On the one hand, it assists Rhizoma Polygoni Cuspidati in dissipating stasis, on the other hand, it promotes qi movement to assist in promoting diuresis. At the same time, its function of dispelling wind combined with Herba Angelicae Pubescentis makes the blood circulate smoothly when the wind subsides, enhancing the analgesic effect; Atractylodes Rhizome is good at drying dampness and strengthening the spleen. When combined with stir-fried Semen Coicis, it can not only enhance the power of Cortex Phellodendri and Herba Artemisiae Scopariae in drying dampness, but also strengthen the spleen to cut off the source of regeneration of damp turbidity; Stir-fried Semen Coicis can assist Atractylodes Rhizome in strengthening the spleen, and at the same time percolate dampness to assist Herba Artemisiae Scopariae and Plantain Seed in excreting damp turbidity. Its function of relieving arthralgia can also relieve joint heaviness and contracture; The above are all adjuvant drugs;

[0021] Achyranthes bidentata invigorates blood circulation, unblocks meridians, tonifies the liver and kidneys, strengthens the lower back and bones, and promotes urination. Its main function is to guide the entire formula downwards to the lower limb joints, enhancing local efficacy. Simultaneously, its blood-activating and diuretic effects assist Ligusticum chuanxiong and Plantago asiatica, addressing both meridian unblocking and dampness elimination. Glycyrrhiza uralensis harmonizes the other herbs, mitigating the stomach-damaging properties of bitter and cold herbs like Phellodendron chinense and Artemisia capillaris, as well as the qi-depleting and stagnant effects of pungent and drying herbs like Angelica pubescens and Lycopodium clavatum. Furthermore, its qi-tonifying and spleen-strengthening effects assist Atractylodes lancea and stir-fried Coix lacryma-jobi in enhancing spleen-strengthening and dampness-eliminating abilities. All of these serve as guiding herbs.

[0022] The above-mentioned drugs work together to create a synergistic effect, primarily expelling pathogens while simultaneously supporting the body's resistance, clearing heat and promoting diuresis, and combining unblocking the meridians with relieving pain. The drugs complement each other and have a good therapeutic effect on gout, rheumatoid arthritis, and osteoarthritis caused by rheumatism combined with damp-heat and deficiency of both liver and kidney. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention; that is, the described embodiments are merely some embodiments of the invention, and not all embodiments.

[0024] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0025] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0026] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0027] Example 1

[0028] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: 25 parts Angelica pubescens, 45 parts Phellodendron chinense, 40 parts Smilax glabra, 20 parts Dioscorea hypoglauca, 40 parts Ligusticum chuanxiong, 20 parts Coix lacryma-jobi, 20 parts Achyranthes bidentata, 40 parts Artemisia capillaris, 40 parts Lycopodium clavatum, 20 parts Polygonum cuspidatum, 20 parts Dipsacus asper, 40 parts Atractylodes lancea, 20 parts Plantago asiatica, and 10 parts Glycyrrhiza uralensis.

[0029] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: the above fourteen ingredients are decocted three times with water. The first decoction is made with 10 times the amount of water, and the second and third decoctions are made with 8 times the amount of water. The decoctions are decocted for 1 hour, filtered, and the filtrates are combined and concentrated under reduced pressure to an extract with a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the mixture is granulated to obtain the final product.

[0030] Example 2

[0031] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: Angelica pubescens 45 parts, Phellodendron chinense 25 parts, Smilax glabra 20 parts, Dioscorea hypoglauca 40 parts, Ligusticum chuanxiong 20 parts, Coix lacryma-jobi 40 parts, Achyranthes bidentata 40 parts, Artemisia capillaris 20 parts, Lycopodium clavatum 20 parts, Polygonum cuspidatum 40 parts, Dipsacus asper 40 parts, Atractylodes lancea 20 parts, Plantago asiatica 40 parts, and Glycyrrhiza uralensis 25 parts.

[0032] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: the above fourteen ingredients are decocted three times with water. The first decoction is made with 10 times the amount of water, and the second and third decoctions are made with 8 times the amount of water. The decoctions are decocted for 1 hour, filtered, and the filtrates are combined and concentrated under reduced pressure to an extract with a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the mixture is granulated to obtain the final product.

[0033] Example 3

[0034] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: 36 parts Angelica pubescens, 36 parts Phellodendron chinense, 30 parts Smilax glabra, 30 parts Dioscorea hypoglauca, 30 parts Ligusticum chuanxiong, 30 parts Coix lacryma-jobi, 30 parts Achyranthes bidentata, 30 parts Artemisia capillaris, 30 parts Lycopodium clavatum, 30 parts Polygonum cuspidatum, 30 parts Dipsacus asper, 30 parts Atractylodes lancea, 30 parts Plantago asiatica, and 18 parts Glycyrrhiza uralensis.

[0035] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: the above fourteen ingredients are decocted three times with water. The first decoction is made with 10 times the amount of water, and the second and third decoctions are made with 8 times the amount of water. The decoctions are decocted for 1 hour, filtered, and the filtrates are combined and concentrated under reduced pressure to an extract with a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the mixture is granulated to obtain the final product.

[0036] Example 4

[0037] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: 30 parts Angelica pubescens, 40 parts Phellodendron chinense, 35 parts Smilax glabra, 25 parts Dioscorea hypoglauca, 35 parts Ligusticum chuanxiong, 25 parts Coix lacryma-jobi, 25 parts Achyranthes bidentata, 35 parts Artemisia capillaris, 35 parts Lycopodium clavatum, 25 parts Polygonum cuspidatum, 25 parts Dipsacus asper, 35 parts Atractylodes lancea, 25 parts Plantago asiatica, and 15 parts Glycyrrhiza uralensis.

[0038] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: the above fourteen ingredients are decocted three times with water. The first decoction is made with 10 times the amount of water, and the second and third decoctions are made with 8 times the amount of water. The decoctions are decocted for 1 hour, filtered, and the filtrates are combined and concentrated under reduced pressure to an extract with a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the mixture is granulated to obtain the final product.

[0039] Example 5

[0040] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: 40 parts Angelica pubescens, 30 parts Phellodendron chinense, 25 parts Smilax glabra, 35 parts Dioscorea hypoglauca, 25 parts Ligusticum chuanxiong, 35 parts Coix lacryma-jobi, 35 parts Achyranthes bidentata, 35 parts Artemisia capillaris, 25 parts Lycopodium clavatum, 35 parts Polygonum cuspidatum, 35 parts Dipsacus asper, 25 parts Atractylodes lancea, 35 parts Plantago asiatica, and 20 parts Glycyrrhiza uralensis.

[0041] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: the above fourteen ingredients are decocted three times with water. The first decoction is made with 10 times the amount of water, and the second and third decoctions are made with 8 times the amount of water. The decoctions are decocted for 1 hour, filtered, and the filtrates are combined and concentrated under reduced pressure to an extract with a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the mixture is granulated to obtain the final product.

[0042] Comparative Example 1

[0043] A traditional Chinese medicine composition for treating joint diseases comprises the following components in parts by weight: Angelica pubescens 36 parts, Notopterygium incisum 36 parts, Phellodendron chinense 36 parts, Angelica sinensis 30 parts, Smilax glabra 30 parts, Saposhnikovia divaricata 30 parts, Dioscorea hypoglauca 30 parts, Alisma plantago-aquatica 24 parts, Ligusticum chuanxiong 30 parts, Trachelospermum jasminoides 30 parts, Coix lacryma-jobi 30 parts, Buthus martensii 9 parts, Achyranthes bidentata 30 parts, Artemisia capillaris 30 parts, Polygonum cuspidatum 30 parts, and Atractylodes lancea 30 parts.

[0044] The preparation method of the above-mentioned traditional Chinese medicine composition for treating joint diseases includes the following steps: the above sixteen ingredients are decocted three times with water. The first decoction is made with 10 times the amount of water, and the second and third decoctions are made with 8 times the amount of water. The decoctions are decocted for 1 hour, filtered, and the filtrates are combined. The extract is concentrated under reduced pressure to a relative density of 1.10-1.15. An appropriate amount of pharmaceutically acceptable excipients are added, and the extract is granulated to obtain the final product.

[0045] Test case

[0046] I. General Information

[0047] Eighty patients came to the hospital and were diagnosed with rheumatoid arthritis, including 45 men and 35 women, with an average age of 58.5 years.

[0048] II. Diagnostic Criteria

[0049] 1. Main manifestations

[0050] Migratory polyarthritis: The most common main manifestation, characterized by involvement of multiple joints (usually ≥2), mainly large joints such as knee, ankle, shoulder, elbow, and wrist. The joints are red, swollen, hot, and painful, with limited range of motion. It is migratory (after the symptoms in one joint are relieved, the symptoms in another joint flare up). No joint deformity is left after the inflammation subsides.

[0051] Other major manifestations include: carditis, chorea, erythema annulare, and subcutaneous nodules;

[0052] 2. Secondary manifestations: Clinical symptoms: fever, joint pain;

[0053] Laboratory indicators: elevated erythrocyte sedimentation rate, elevated C-reactive protein, and increased white blood cell count; electrocardiogram showed prolonged PR interval;

[0054] 3. Evidence of streptococcal infection

[0055] Positive throat swab culture or rapid streptococcal antigen test;

[0056] Elevated titers of anti-streptolysin O or other streptococcal antibodies;

[0057] For diagnosis, the following conditions must be met simultaneously: evidence of streptococcal infection, two major manifestations, or one major manifestation plus two minor manifestations.

[0058] III. Treatment Methods

[0059] The patients were randomly divided into two groups of 40 each. The first group of patients took the drug in Example 5, and the second group of patients took the drug in Comparative Example 1. They took 10g three times a day, each time. Each 1g is equivalent to 2.33g of the original medicinal material. They took the drug continuously for 3 months, and the patients' treatment was observed and recorded.

[0060] IV. Efficacy Evaluation Criteria

[0061] 1. Improvement in clinical symptoms and signs

[0062] Joint symptoms: Joint pain, swelling, redness, and limited range of motion completely disappear or are significantly reduced, and the frequency of attacks decreases;

[0063] Systemic symptoms: Fever, fatigue, etc. completely subsided, and no new joints were affected.

[0064] 2. Recovery of inflammatory markers

[0065] Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels returned to normal.

[0066] White blood cell count returned to normal.

[0067] 3. Control of Streptococcal Infections

[0068] The streptococcal antibody titer gradually decreased to normal.

[0069] There is no evidence of new streptococcal infection.

[0070] 4. No complications or recurrence

[0071] No carditis has developed or the existing carditis has not worsened;

[0072] No recurrence of arthritis was observed during the follow-up period.

[0073] Cure: Joint symptoms and systemic symptoms have completely disappeared, inflammatory markers are normal, and there is no evidence of active streptococcal infection;

[0074] Significant effect: Joint symptoms are significantly reduced, systemic symptoms disappear, inflammatory markers decrease by ≥50%, and streptococcal infection is controlled;

[0075] Effective: Joint symptoms are reduced, inflammatory markers decrease, and there is no worsening;

[0076] Ineffective: Symptoms, signs, and inflammatory markers do not improve or worsen, or even complications such as carditis occur.

[0077] Effectiveness rate (%) = (Number of cured patients + Number of patients with significant improvement + Number of patients with effective results) / Total number of patients * 100%

[0078] V. Treatment Results

[0079]

[0080] The data in the table above shows that the drug in Example 5 has a 100% efficacy rate in treating rheumatoid arthritis, while the drug in Comparative Example 1 has a 62.5% efficacy rate. Both drugs have good therapeutic effects, but the drug in Example 1 is slightly more effective than the drug in Comparative Example 1. Furthermore, the experimental data shows that the drug in Example 1 resulted in more patients recovering, proving that the drug in Example 1 can shorten the treatment cycle and has a better therapeutic effect. It is speculated that after the composition of the drugs in Comparative Example 1 was adjusted, the interaction between the drugs in the composition was weakened or disappeared, resulting in a worse therapeutic effect.

Claims

1. A traditional Chinese medicine composition for treating joint diseases, characterized in that, The components include the following weight parts: 25-45 parts of Angelica pubescens, 25-45 parts of Phellodendron amurense, 20-40 parts of Smilax glabra, 20-40 parts of Alisma orientale, 20-40 parts of Ligusticum chuanxiong, 20-40 parts of Coix lachryma-jobi, 20-40 parts of Cyathula officinalis, 20-40 parts of Artemisia capillaris, 20-40 parts of Pyrrosia calcicola, 20-40 parts of Polygonum cuspidatum, 20-40 parts of Dipsacus asper, 20-40 parts of Plantago asiatica, and 10-25 parts of Glycyrrhiza uralensis.

2. The Chinese medicine composition for treating joint disease according to claim 1, wherein, The components include the following weight parts: 30-40 parts of Angelica pubescens, 30-40 parts of Phellodendron amurense, 25-35 parts of Smilax glabra, 25-35 parts of Alisma orientale, 25-35 parts of Ligusticum chuanxiong, 25-35 parts of Coix lachryma-jobi, 25-35 parts of Cyathula officinalis, 25-35 parts of Artemisia capillaris, 25-35 parts of Pyrrosia calcicola, 25-35 parts of Polygonum cuspidatum, 25-35 parts of Dipsacus asper, 25-35 parts of Plantago asiatica, and 15-20 parts of Glycyrrhiza uralensis.

3. The Chinese medicine composition for treating joint disease according to claim 1, wherein the Chinese medicine composition is prepared by mixing the Chinese medicine extract and the pharmaceutically acceptable carrier. The components include the following weight parts: 30 parts of Angelica pubescens, 40 parts of Phellodendron amurense, 35 parts of Smilax glabra, 25 parts of Alisma orientale, 35 parts of Ligusticum chuanxiong, 25 parts of Coix lachryma-jobi, 25 parts of Cyathula officinalis, 35 parts of Artemisia capillaris, 35 parts of Pyrrosia calcicola, 25 parts of Polygonum cuspidatum, 25 parts of Dipsacus asper, 25 parts of Plantago asiatica, and 15 parts of Glycyrrhiza uralensis.

4. The Chinese medicine composition for treating joint disease according to claim 1, wherein the Chinese medicine composition is prepared by mixing the Chinese medicine extract and the pharmaceutically acceptable carrier. The components include the following weight parts: 40 parts of Angelica pubescens, 30 parts of Phellodendron amurense, 25 parts of Smilax glabra, 35 parts of Alisma orientale, 25 parts of Ligusticum chuanxiong, 35 parts of Coix lachryma-jobi, 35 parts of Cyathula officinalis, 25 parts of Artemisia capillaris, 25 parts of Pyrrosia calcicola, 35 parts of Polygonum cuspidatum, 35 parts of Dipsacus asper, 25 parts of Plantago asiatica, and 20 parts of Glycyrrhiza uralensis.

5. The Chinese medicine composition for treating joint disease according to claim 1, wherein the Chinese medicine composition is prepared by mixing the Chinese medicine extract and the pharmaceutically acceptable carrier. The components include the following weight parts: 36 parts of Angelica pubescens, 36 parts of Phellodendron amurense, 30 parts of Smilax glabra, 30 parts of Alisma orientale, 30 parts of Ligusticum chuanxiong, 30 parts of Coix lachryma-jobi, 30 parts of Cyathula officinalis, 30 parts of Artemisia capillaris, 30 parts of Pyrrosia calcicola, 30 parts of Polygonum cuspidatum, 30 parts of Dipsacus asper, 30 parts of Plantago asiatica, and 18 parts of Glycyrrhiza uralensis.

6. The Chinese medicine composition for treating joint disease according to any one of claims 1 to 5, wherein The Coix lachryma-jobi is fermented Coix lachryma-jobi.

7. The method for preparing the traditional Chinese medicine composition for treating joint diseases according to claim 1, characterized in that, The method includes the following steps: The raw medicinal materials are ground and mixed; or extracts obtained by mixing or separately extracting the raw medicinal materials are prepared; or effective components obtained by further refining and purifying the extracts are prepared; or the extracts / effective components are added to pharmaceutically acceptable excipients.

8. The method for preparing the traditional Chinese medicine composition for treating joint diseases according to claim 1, characterized in that, The prepared dosage form is one of a pill, granule, capsule, powder, mixture, tablet, decoction, or oral liquid.

9. The method for preparing the traditional Chinese medicine composition for treating joint diseases according to claim 1, characterized in that, The fourteen ingredients are decocted with water, filtered, and the filtrates are combined and concentrated under reduced pressure to a relative density of 1.10-1.

15. Appropriate pharmaceutically acceptable excipients are added to prepare granules.

10. Use of the traditional Chinese medicine composition for treating joint diseases according to any one of claims 1-6 in the preparation of a medicament for treating joint diseases.

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