Traditional Chinese medicine hot compress bag for treating pulmonary fibrosis

Abstract

The invention discloses a traditional Chinese medicine hot compress bag for treating pulmonary fibrosis, and relates to the technical field of traditional Chinese medicine compositions, the hot compress bag is composed of a non-woven fabric layer, a water-resisting layer, a heat preservation layer, a medicine applying layer, a fixing layer and a plurality of traditional Chinese medicinal materials wrapped in the medicine applying layer, according to the hot compress bag, the non-woven fabric layer serves as an integrated main body of the hot compress bag and is convenient to combine, the water-resisting layer is waterproof, moisture-proof and capable of preventing water vapor from invading, the medicine applying layer is arranged in the non-woven fabric layer, powdery traditional Chinese medicinal materials can be conveniently filled, and the hot compress bag is convenient to use. The heat preservation layer is used for achieving heat preservation and enhancing the hot compress effect, the fixing layer facilitates adhesion and contact of the hot compress bag and the skin and ensures fixation of the hot compress bag, through the combination, permeation and absorption of traditional Chinese medicine ingredients in the hot compress bag through the skin are conveniently promoted, pulmonary symptoms are relieved in an auxiliary mode, and the use effect of the traditional Chinese medicine composition is improved through hot compress.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, specifically a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis. Background Technology

[0002] Pulmonary fibrosis is a serious lung disease characterized by the gradual replacement of lung tissue with fibrous tissue, leading to a progressive decline in lung function. Pulmonary fibrosis is characterized by abnormal lung tissue repair leading to alveolar structure destruction and progressive decline in lung function, resulting in a poor prognosis. Traditional Chinese medicine hot compress packs are a traditional Chinese medicine therapy that combines syndrome differentiation and selection of medicines with heat therapy. The core of the therapy is to grind Chinese medicine into powder, put it into a cloth bag, heat it, and apply it to the affected area. The therapeutic effect is achieved through heat penetration and drug action. The principle is to dilate local capillaries through warmth, promote blood circulation, and enhance drug absorption, thereby achieving the purpose of regulating qi and blood and relieving pain. The efficacy of traditional Chinese medicine hot compress packs depends on the compatibility of medicinal materials. Currently, treatment options for pulmonary fibrosis are limited and the results are unsatisfactory. Western medicine often uses glucocorticoids and immunosuppressants, but these have many side effects and long-term use may lead to other complications. Traditional Chinese medicine (TCM) has unique advantages in treating pulmonary fibrosis. The multi-target mechanism of TCM can regulate the body's functions as a whole, alleviate symptoms, and slow disease progression. However, existing TCM treatment plans still need further improvement in terms of efficacy and safety. Therefore, developing a highly effective and safe TCM combination for treating pulmonary fibrosis is of great practical significance. Summary of the Invention

[0003] This invention provides a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis, which can effectively solve the problems mentioned in the background art, such as the limited treatment methods for pulmonary fibrosis and unsatisfactory effects, the many side effects of Western medicine treatment, and the possibility of other complications with long-term use, while the efficacy and safety of traditional Chinese medicine treatment still need to be further improved.

[0004] To achieve the above objectives, the present invention provides the following technical solution: a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis, the hot compress pack being composed of a non-woven fabric layer, a waterproof layer, a heat-insulating layer, a medicated dressing layer and a fixing layer, as well as a combination of various traditional Chinese medicinal materials wrapped within the medicated dressing layer; The non-woven fabric layer serves as the main component of the heat pack, and a waterproof layer is adhered to the outer layer of the non-woven fabric layer to provide moisture and water protection. The non-woven fabric layer is provided with a medicated dressing layer, which is filled with the traditional Chinese medicine composition. The traditional Chinese medicine materials in the medicated dressing layer are ground and mixed evenly in powder form before being wrapped by the medicated dressing layer. An insulation layer is provided between the non-woven fabric layer and the medicated dressing layer to keep the hot compress warm. The insulation layer is specifically polyurethane foam. The innermost layer of the non-woven fabric layer is in adhesive contact with the user's skin through a fixing layer, which is specifically a traceless adhesive film. The specific Chinese herbal combinations within the medicated dressing layer include Astragalus membranaceus, Hedyotis diffusa, Taraxacum mongolicum, Trichosanthes kirilowii, Allium macrostemon, Polygonum cuspidatum, Perilla frutescens, Ligusticum chuanxiong, and Glycyrrhiza uralensis.

[0005] According to the above technical solution, the various traditional Chinese medicine compositions within the medicated dressing layer, by weight, are as follows: Astragalus membranaceus 20-40 parts, Hedyotis diffusa 25-35 parts, Taraxacum mongolicum 20-40 parts, Trichosanthes kirilowii 18-30 parts, Allium macrostemon 20-28 parts, Polygonum cuspidatum 10-20 parts, Perilla frutescens 10-30 parts, Ligusticum chuanxiong 8-16 parts, Glycyrrhiza uralensis 2-10 parts.

[0006] According to the above technical solution, Astragalus membranaceus has the effects of tonifying qi and consolidating the exterior, promoting diuresis and eliminating toxins, draining pus, and promoting wound healing and tissue regeneration; Hedyotis diffusa has the effects of clearing heat and detoxifying, and promoting diuresis and relieving strangury; Taraxacum mongolicum has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules, and promoting diuresis and relieving strangury; Trichosanthes kirilowii has the effects of clearing heat and eliminating phlegm, widening the chest and dissipating nodules, and moistening dryness and lubricating the intestines; Allium macrostemon has the effects of promoting yang and dissipating nodules, and regulating qi and relieving stagnation.

[0007] According to the above technical solution, the Polygonum cuspidatum has the effects of promoting diuresis and relieving jaundice, clearing heat and detoxifying, dispersing blood stasis and relieving pain, and relieving cough and resolving phlegm. The Perilla frutescens has the effects of lowering qi and resolving phlegm, relieving cough and asthma, and moistening the intestines and promoting bowel movement. The Ligusticum chuanxiong has the effects of promoting blood circulation and regulating qi, dispelling wind and relieving pain. The Glycyrrhiza uralensis has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasms and pain, and harmonizing the effects of other medicines.

[0008] A method for applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis, wherein the traditional Chinese medicine composition in the hot compress pack is used in the preparation of drugs for treating idiopathic pulmonary fibrosis and secondary pulmonary fibrosis, including local hot compress application and oral administration of decoction.

[0009] According to the above technical solution, the local hot compress application specifically includes the following steps: Step A: Heat and activate the hot compress pack; Step B: Pre-treatment of the area to be treated with heat; Step C: Apply the patch to the affected area; Step D: Post-use treatment of the hot compress pack.

[0010] According to the above technical solution, in step A, first check that the hot compress pack is intact and undamaged, and that the waterproof layer is sealed, and then gently rub the hot compress pack to distribute the medicine powder evenly. Next, preheat the hot compress pack by heating it at a low temperature in a microwave oven for 1-2 minutes, so that the hot compress pack reaches 40-50 degrees Celsius before use. Step B involves cleaning the area corresponding to the patient's chest and lungs, and keeping that area dry. In step C, during the application process, the preheated hot compress pack is directly adhered to the hot compress area on the skin through the fixing layer. The specific location can be selected at the Feishu acupoint corresponding to the chest and lung area. Light pressure is used to ensure that it adheres to the skin. Before application, the temperature of the hot compress pack needs to be tested by touching it with the back of the hand. During the hot compress process, the heat insulation layer is used to maintain the temperature, and the application time is controlled to 15-30 minutes each time, 1-2 times a day; Step D involves gently peeling off the heat pack after the heat compress time has ended and then gently stroking the skin.

[0011] According to the above technical solution, the application of the decoction for warm administration specifically includes the following steps: Step E: Prepare the traditional Chinese medicine composition; Step F: Simmer in the clay pot twice in separate steps; Step G: Specific application of the decoction by warm administration; Step H: Verification of the efficacy of the traditional Chinese medicine combination.

[0012] According to the above technical solution, in step E, a specific weight ratio of Astragalus membranaceus, Hedyotis diffusa, Taraxacum mongolicum, Trichosanthes kirilowii, Allium macrostemon, Polygonum cuspidatum, Perilla frutescens, Ligusticum chuanxiong and Glycyrrhiza uralensis are prepared, and the Chinese herbal medicine composition is washed with clean water to remove surface impurities. In step F, a clay pot is used as a simmering container, and the decoction is obtained through two simmering processes. During the first decoction, put the washed Chinese herbal medicine mixture into a clay pot, add 1000ml of water, soak for 30 minutes to allow the herbs to fully absorb water, then bring to a boil over high heat, then simmer over low heat for 40 minutes. Use gauze to separate the liquid and dregs to obtain the first decoction. During the second decoction, add 800ml of water to the dregs, bring to a boil over high heat again, then simmer over low heat for 30 minutes. Filter again to obtain the decoction from the first decoction. Combine the decoctions from the two decoctions to obtain 500ml of soup. If the total amount of soup is less than 500ml, add water as needed. If there is too much soup, concentrate it to an appropriate amount. If there are obvious impurities in the soup, it needs to be filtered again.

[0013] According to the above technical solution, in step G, the obtained decoction is heated and taken in three separate doses, specifically in the morning, noon and evening of the same day, with each dose being 160-170ml, one dose per day, for three consecutive months. In step H, during the verification process, animal experiments were conducted. A rat model of idiopathic pulmonary fibrosis was prepared by intratracheal instillation of bleomycin. On the day after modeling, the rats were administered physiological saline, positive control drug, and Tongbi Huaxianfang (a traditional Chinese medicine formula) at high, medium, and low doses by gavage. Once daily for 28 consecutive days, rats were fasted for 12 hours before sampling but allowed free access to water. The general condition of the rats, lung coefficient, lung tissue pathological section staining, and HYP level were observed using ELISA.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The non-woven fabric layer serves as the main body of the heat pack, facilitating assembly. The waterproof layer prevents moisture penetration and keeps the Chinese medicine dry. The herbal dressing layer is placed inside the non-woven fabric layer for easy filling with powdered Chinese medicinal materials. The heat insulation layer provides warmth and enhances the heat pack effect. The fixing layer facilitates the adhesion between the heat pack and the skin, ensuring the heat pack is securely fixed. This combination promotes the absorption of the Chinese medicine ingredients in the heat pack through the skin, helping to relieve lung symptoms and enhancing the efficacy of the Chinese medicine composition through heat application. Furthermore, by filling the hot compress pack with Hedyotis diffusa, dandelion, and Polygonum cuspidatum, inflammatory factors in the lungs can be cleared, reducing alveolitis damage. Trichosanthes kirilowii, Allium macrostemon, and Perilla frutescens can dilute phlegm, promote lung qi circulation, and relieve pulmonary congestion. Ligusticum chuanxiong can improve pulmonary circulation and inhibit abnormal proliferation of fibroblasts. Astragalus membranaceus can replenish qi and detoxify, while Glycyrrhiza uralensis can harmonize the various herbs and enhance immunity. Through multi-target action, the progression of pulmonary fibrosis can be inhibited. The combination of multiple components can delay collagen deposition, repair alveolar structure, and ultimately improve lung function.

[0015] 2. By applying the hot compress pack locally, the heat promotes transdermal drug absorption. Combined with acupoint stimulation, it achieves targeted local treatment. The heating method is simple and easy to operate, convenient to use, and the hot compress can dilate local skin blood vessels, accelerate drug penetration, relieve muscle tension, and improve blood circulation in the lung area. Furthermore, the herbal powder composition inside the hot compress pack directly contacts the skin, allowing the effective ingredients of the herbs to penetrate through pores or the stratum corneum to the subcutaneous layer, acting on the corresponding lung back-shu points to regulate the qi and blood of the lung meridian and relieve symptoms such as cough and chest tightness. At the same time, the non-marking adhesive film fixation avoids frequent adjustments, making it convenient to use and reducing the risk of skin irritation. Microwave heating is simple and easy to implement, making it suitable for home-based adjunctive treatment.

[0016] 3. By decocting the Chinese herbal medicine composition in the hot compress pack and taking it orally, it can be absorbed and conveniently regulate the body's condition, inhibit the progression of fibrosis. The two decoctions can maximize the extraction of the effective components of the Chinese medicine and ensure the full release of the medicine. It can reduce the lung coefficient, reduce hydroxyproline levels, inhibit collagen deposition, and enhance the effect of warm application. Continuous use for 3 months can enhance the body's immunity, relieve cough and asthma, and regulate immunity and function. Attached Figure Description

[0017] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the embodiments of the invention to explain the invention and do not constitute a limitation thereof.

[0018] In the attached diagram: Figure 1 This is a schematic diagram of the composition of the hot compress pack of the present invention; Figure 2 This is a flowchart of the steps for applying local heat therapy externally according to the present invention; Figure 3 This is a flowchart illustrating the steps involved in the application of the decoction for warm administration according to the present invention. Figure 4 These are HE staining images of blank rat lung pathological sections from each group in this invention; Figure 5 These are HE staining images of the rat lung pathological section model groups of this invention; Figure 6 These are HE staining images of the positive drug groups in the lung pathological sections of rats in each group according to the present invention; Figure 7 These are HE staining images of high-dose rat lung pathological sections from various groups in this invention; Figure 8 These are HE staining images of the dosage groups in the lung pathological sections of rats in each group of this invention; Figure 9 These are HE staining images of low-dose rat lung pathological sections from various groups in this invention; Figure 10 These are Masson staining images of blank rat lung pathological sections from each group in this invention; Figure 11 These are Masson staining images of the rat lung pathological section model groups of this invention; Figure 12 These are Masson staining images of the positive drug groups in the lung pathological sections of rats in each group according to the present invention; Figure 13 These are Masson staining images of high-dose rat lung pathological sections from various groups in this invention; Figure 14 These are Masson staining images of the dosage groups in the lung pathological sections of rats in each group of this invention; Figure 15 These are Masson staining images of low-dose rat lung pathological sections from various groups in this invention. The labels in the diagram are: 1. Non-woven fabric layer; 2. Waterproof layer; 3. Thermal insulation layer; 4. Medicated dressing layer; 5. Fixing layer. Detailed Implementation

[0019] The preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0020] like Figure 1 As shown, the present invention provides a technical solution, a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis, the hot compress pack is composed of a non-woven fabric layer, a waterproof layer, a heat insulation layer, a medicated layer and a fixing layer, as well as a combination of various traditional Chinese medicines wrapped in the medicated layer; The non-woven fabric layer is the main component of the hot compress pack. The outer layer of the non-woven fabric layer is adhered with a water-proof layer. The water-proof layer is used to prevent moisture and water from entering the hot compress pack and to keep the Chinese medicine composition inside the hot compress pack dry. The non-woven fabric layer has a medicated dressing layer inside. The medicated dressing layer is filled with the Chinese medicine composition and is responsible for the release of the drug components. The Chinese medicinal materials in the medicated dressing layer are ground and mixed evenly in powder form before being wrapped by the medicated dressing layer. An insulation layer is set between the non-woven fabric layer and the medicated dressing layer to keep the hot compress pack warm and improve the hot compress effect of the Chinese herbal medicine. The insulation layer is specifically polyurethane foam. The innermost layer of the non-woven fabric layer is in adhesive contact with the user's skin through a fixing layer, which is a traceless adhesive film to ensure the stability of the hot compress pack's adhesion. The specific Chinese herbal combinations within the medicated dressing layer include Astragalus membranaceus, Hedyotis diffusa, Taraxacum mongolicum, Trichosanthes kirilowii, Allium macrostemon, Polygonum cuspidatum, Perilla frutescens, Ligusticum chuanxiong, and Glycyrrhiza uralensis.

[0021] Based on the above technical solution, the various traditional Chinese medicine compositions within the medicated dressing layer, by weight, are as follows: Astragalus membranaceus 30 parts, Hedyotis diffusa 30 parts, Taraxacum mongolicum 30 parts, Trichosanthes kirilowii 24 parts, Allium macrostemon 24 parts, Polygonum cuspidatum 15 parts, Perilla frutescens 20 parts, Ligusticum chuanxiong 12 parts, Glycyrrhiza uralensis 6 parts.

[0022] Based on the above technical solutions, Astragalus membranaceus has the effects of tonifying qi and strengthening the exterior, promoting diuresis and eliminating toxins, draining pus, and promoting wound healing and tissue regeneration. Astragalus membranaceus can regulate immune function, reduce lung inflammation, and inhibit the proliferation of lung fibroblasts, thereby delaying the process of pulmonary fibrosis. At the same time, Astragalus membranaceus can also improve lung blood circulation, provide sufficient nutrients for damaged lung tissue, and promote its repair. Hedyotis diffusa has the effects of clearing heat and detoxifying, promoting diuresis and relieving strangury. It can effectively inhibit the release of inflammatory factors, reduce chronic inflammatory response in the lungs, and thus reduce the continuous damage of inflammation to lung tissue. At the same time, it can also inhibit the abnormal proliferation of lung fibroblasts, reduce the excessive deposition of extracellular matrix, and delay the development of pulmonary fibrosis. In addition, it can also enhance the body's antioxidant capacity, protect lung epithelial cells, and promote the repair of damaged lung tissue. Dandelion has the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules, and promoting diuresis and relieving strangury. Dandelion can regulate the body's immune function and inhibit the attack of overactive immune response on the lungs. It can reduce inflammatory infiltration in the lungs, lower the level of inflammatory factors, and relieve lung inflammation. At the same time, dandelion can inhibit the proliferation of lung fibroblasts and the synthesis of collagen, reduce the formation of pulmonary fibrosis lesions, and improve the lung microenvironment, promote lung metabolism, and help the recovery of damaged lung tissue. Trichosanthes kirilowii has the effects of clearing heat and resolving phlegm, relieving chest congestion and dispersing nodules, and moistening dryness and lubricating the intestines. Trichosanthes kirilowii can inhibit the expression of fibrosis-related cytokines, reduce the activation and proliferation of fibroblasts, thereby delaying the progression of pulmonary fibrosis. It can improve pulmonary blood circulation, increase pulmonary blood supply, provide sufficient nutrition and oxygen to damaged lung tissue, and promote its repair. In addition, Trichosanthes kirilowii can reduce pulmonary mucus secretion, alleviate airway obstruction, and improve pulmonary ventilation function. Allium macrostemon has the effects of promoting yang and dispersing nodules, regulating qi and relieving stagnation. Allium macrostemon can inhibit platelet aggregation and the release of inflammatory factors, reduce pulmonary microcirculation disorders and inflammatory responses. It can downregulate the expression of α-smooth muscle actin, prevent the transformation of pulmonary epithelial cells into interstitial cells, and inhibit the development of pulmonary fibrosis. At the same time, Allium macrostemon can also regulate lipid metabolism, reduce the damage of lipid peroxidation products to lung tissue, and protect lung function.

[0023] Based on the above technical solutions, Polygonum cuspidatum has the effects of promoting diuresis and relieving jaundice, clearing heat and detoxifying, dispersing blood stasis and relieving pain, and relieving cough and resolving phlegm. The active ingredients in Polygonum cuspidatum have strong antioxidant effects, which can scavenge oxygen free radicals and reduce oxidative stress damage to lung tissue. It can inhibit the release of inflammatory factors and the activation of the NF-κB signaling pathway, thereby reducing lung inflammation. At the same time, Polygonum cuspidatum can downregulate TGF-β1 / Smad3 signaling, inhibit the proliferation of fibroblasts and the deposition of collagen, and promote the degradation of extracellular matrix, thereby delaying the process of pulmonary fibrosis. Perilla seeds have the effects of lowering qi and resolving phlegm, relieving cough and asthma, and moistening the intestines and promoting bowel movements. The α-linolenic acid in perilla seeds can inhibit the release of pro-inflammatory factors and reduce lung inflammation. It can enhance the body's antioxidant capacity and reduce the damage of oxidative stress to lung tissue. At the same time, perilla seeds can regulate immune balance, inhibit the differentiation of Th17 cells, reduce IL-17-mediated inflammatory response, and thus inhibit the development of pulmonary fibrosis. In addition, perilla seeds can also improve lung ventilation function and relieve cough and asthma symptoms. Ligusticum chuanxiong has the effects of promoting blood circulation, dispelling wind and relieving pain. The ligustrazine component in Ligusticum chuanxiong can dilate pulmonary blood vessels, improve pulmonary blood circulation, reduce the formation of microthrombi, and relieve the ischemic and hypoxic state of pulmonary tissue. It can inhibit the proliferation of fibroblasts induced by TGF-β1 and reduce the expression of type I collagen, thereby inhibiting the process of pulmonary fibrosis. At the same time, Ligusticum chuanxiong can also reduce inflammatory infiltration in the lungs, reduce the level of inflammatory factors, and protect lung tissue. Licorice has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving pain and pain, and harmonizing other medicines. The glycyrrhizic acid in licorice can inhibit the NF-κB pathway, reduce the release of inflammatory factors, enhance the activity of glucocorticoid receptors, and synergistically exert anti-inflammatory effects to reduce lung inflammation. It can scavenge free radicals, reduce oxidative damage to lung tissue, and has a detoxifying effect, reducing the stimulation of toxins on lung cells. In addition, licorice can harmonize the properties of other medicines in the prescription, reduce adverse reactions, enhance the overall therapeutic effect, and promote the repair of lung tissue.

[0024] like Figure 2 As shown in Example 1: A method for applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis, wherein the traditional Chinese medicine composition in the hot compress pack is used in the preparation of drugs for treating idiopathic pulmonary fibrosis (IPF) and secondary pulmonary fibrosis, including topical hot compress application, which includes the following steps: Step A: Heat and activate the hot compress pack; Step B: Pre-treatment of the area to be treated with heat; Step C: Apply the patch to the affected area; Step D: Post-use treatment of the hot compress pack.

[0025] Based on the above technical solution, in step A, first check that the hot compress pack is intact and undamaged, and that the waterproof layer is sealed to prevent the medicine from getting damp, and gently rub the hot compress pack to make the medicine powder evenly distributed. Next, preheat the hot compress pack by heating it at a low temperature in a microwave oven for 2 minutes, so that the hot compress pack reaches 47 degrees Celsius before use. Step B involves cleaning the area corresponding to the patient's chest and lungs, and keeping the area dry to enhance the adhesion of the heat pack's fixation layer. Step C: During the application process, the preheated hot compress pack is directly adhered to the hot compress area on the skin through the fixing layer. The specific location can be selected at the Feishu acupoint corresponding to the chest and lung area. Light pressure is used to ensure that it adheres to the skin. Before applying, the temperature of the hot compress pack needs to be tested by touching it with the back of your hand. The temperature should be warm but not scalding to avoid overheating and causing burns. During the hot compress process, the heat insulation layer is used to maintain the temperature, and the application time is controlled to 15-30 minutes each time, twice a day; Step D involves gently peeling off the heat pack after the heat compress time is over and lightly patting the skin to avoid irritation.

[0026] like Figure 3 As shown in Example 2: A method for applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis. The application of the traditional Chinese medicine composition in the hot compress pack in the preparation of drugs for treating idiopathic pulmonary fibrosis (IPF) and secondary pulmonary fibrosis includes the application of a decoction taken orally while warm. The application of the decoction taken orally while warm includes the following steps: Step E: Prepare the traditional Chinese medicine composition; Step F: Simmer in the clay pot twice in separate steps; Step G: Specific application of the decoction by warm administration; Step H: Verification of the efficacy of the traditional Chinese medicine combination.

[0027] Based on the above technical solution, in step E, specifically prepare the following ingredients in the specified weight proportions: Astragalus membranaceus, Hedyotis diffusa, Taraxacum mongolicum, Trichosanthes kirilowii, Allium macrostemon, Polygonum cuspidatum, Perilla frutescens, Ligusticum chuanxiong, and Glycyrrhiza uralensis. Wash the herbal composition with clean water to remove surface impurities and ensure that it is clean, dry, and intact. Step F: Use a clay pot as a decoction container to avoid metal utensils affecting the efficacy of the medicine, and obtain the decoction by decoction twice. During the first decoction, put the washed Chinese herbal medicine combination into a clay pot, add 1000ml of water, soak for 30 minutes to allow the herbs to fully absorb water, which is conducive to the dissolution of active ingredients. Then bring to a boil over high heat, then simmer over low heat for 40 minutes. Use gauze to separate the liquid and dregs to obtain the first decoction. During the second decoction, add 800ml of water to the dregs, bring to a boil over high heat again, then simmer over low heat for 30 minutes. Filter again to obtain the decoction from the first decoction. Combine the decoctions from the two decoctions to obtain 500ml of decoction. If the total volume of the decoction is less than 500ml, add water as needed. If there is an excess, concentrate it to an appropriate amount. If there are obvious impurities in the decoction, it needs to be filtered again. Step G: Heat the obtained decoction into three portions and take them warm to avoid irritating the gastrointestinal tract when taken cold. Specifically, take it warm once each in the morning, noon and evening on the same day, with a dosage of 165ml each time, one dose per day, for three consecutive months. Step H: During the verification process, animal experiments were conducted. A rat model of idiopathic pulmonary fibrosis was prepared by intratracheal instillation of bleomycin. On the day after modeling, the rats were administered physiological saline, positive control drug, and Tongbi Huaxianfang (a traditional Chinese medicine formula) at high, medium, and low doses by gavage. Once daily for 28 consecutive days, rats were fasted for 12 hours before sampling but allowed free access to water. The general condition of the rats, lung coefficient, lung tissue pathological section staining, and HYP level were observed by ELISA. General observation results: The rats in the blank group were in good mental condition, their body weight steadily increased, their fur was white and smooth, their lips were not cyanotic, and their food and water intake were normal. The rats in the model group preferred quiet and were less active. Their body weight increase slowed down in the early stage, and began to slowly recover after 14 days. Their fur was slightly yellow and dry, their lips were cyanotic, their food and water intake decreased, and some of them adopted a hunched back posture. The overall condition of the rats in each drug administration group was between that of the blank group and the model group. Lung coefficient statistics: The lung coefficient statistics of rats in each group treated with Tongbi Huaxianfang for IPF are shown in Table 1 below:

[0028] In Table 1, "#" indicates that the result is significant compared with the blank group (P < 0.05), and "##" indicates that the result is extremely significant compared with the blank group (P < 0.01). “ "" indicates that the result is significant compared to the model group, P < 0.05. "" indicates that the result is highly significant compared to the model group, P < 0.01; Statistical results showed that compared with the blank group, the lung coefficient of rats in the model group was significantly increased (P<0.01). Compared with the model group, the lung coefficient of the positive drug pirfenone group, the high- and medium-dose Tongbi Huaxianfang group was significantly decreased (P<0.05), and there was no significant difference in the low-dose Tongbi Huaxianfang group. Statistical analysis of lung tissue pathological section staining results: including statistical analysis of HE staining of lung pathological sections of rats in each group treated with Tongbi Huaxianfang for IPF and statistical analysis of collagen deposition in lung tissue of rats in each group treated with Tongbi Huaxianfang for IPF; like Figure 4-9 As shown in Table 2, the statistical results of HE staining of lung pathological sections are as follows:

[0029] In Table 2: "#" indicates that the result is significant compared with the blank group, P < 0.05, and "##" indicates that the result is extremely significant compared with the blank group, P < 0.01; “ "" indicates that the result is significant compared to the model group, P < 0.05. "" indicates that the result is highly significant compared to the model group, P < 0.01; Statistical results showed that compared with the blank group, the HE staining score of lung pathological sections in the model group was significantly increased (P<0.01). Compared with the model group, the HE staining score of lung pathological sections in the medium dose group of Tongbi Huaxianfang was decreased (P<0.05). There were no statistically significant differences in the other groups. like Figure 10-15 As shown in Table 3, the statistical results of collagen deposition in lung tissue are as follows:

[0030] In Table 3: "#" indicates that the result is significant compared with the blank group, P < 0.05, and "##" indicates that the result is extremely significant compared with the blank group, P < 0.01; “ "" indicates that the result is significant compared to the model group, P < 0.05. "" indicates that the result is highly significant compared to the model group, P < 0.01; Statistical results showed that compared with the blank group, collagen deposition in the lung tissue of the model group was significantly increased (P<0.01). Compared with the model group, collagen deposition in the lung tissue of the positive drug pirfenone group, the high- and medium-dose Tongbi Huaxianfang group was significantly decreased (P<0.01). There was no significant difference between the low-dose Tongbi Huaxianfang group and the model group (P<0.05). HYP Level Detection by Elisa: The statistical results of serum hydroxyproline (HYP) levels in rats treated with Tongbi Huaxian Fang for IPF are shown in Table 4 below.

[0031] In Table 4: "#" indicates that the result is significant compared with the blank group, P < 0.05, and "##" indicates that the result is extremely significant compared with the blank group, P < 0.01; “ "" indicates that the result is significant compared to the model group, P < 0.05. "" indicates that the result is highly significant compared to the model group, P < 0.01; Statistical results showed that compared with the blank group, the HYP level in the model group rats was significantly increased (P<0.01). Compared with the model group, the levels in the positive drug pirfenone group, the high, medium and low dose groups of Tongbi Huaxianfang were significantly decreased (P<0.01). The experimental results above show that Tongbi Huaxianfang can improve lung coefficient and inflammatory response.

[0032] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine hot compress pack for treating pulmonary fibrosis, characterized in that: The hot compress pack consists of a non-woven fabric layer, a waterproof layer, a heat insulation layer, a medicated dressing layer, and a fixing layer, as well as a combination of various Chinese medicinal herbs wrapped inside the medicated dressing layer; The non-woven fabric layer serves as the main component of the heat pack, and a waterproof layer is adhered to the outer layer of the non-woven fabric layer to provide moisture and water protection. The non-woven fabric layer is provided with a medicated dressing layer, which is filled with the traditional Chinese medicine composition. The traditional Chinese medicine materials in the medicated dressing layer are ground and mixed evenly in powder form before being wrapped by the medicated dressing layer. An insulation layer is provided between the non-woven fabric layer and the medicated dressing layer to keep the hot compress warm. The insulation layer is specifically polyurethane foam. The innermost layer of the non-woven fabric layer is in adhesive contact with the user's skin through a fixing layer, which is specifically a traceless adhesive film. The specific Chinese herbal combinations within the medicated dressing layer include Astragalus membranaceus, Hedyotis diffusa, Taraxacum mongolicum, Trichosanthes kirilowii, Allium macrostemon, Polygonum cuspidatum, Perilla frutescens, Ligusticum chuanxiong, and Glycyrrhiza uralensis.

2. The traditional Chinese medicine hot compress pack for treating pulmonary fibrosis according to claim 1, characterized in that: The herbal compositions within the medicated dressing layer, by weight, are as follows: Astragalus membranaceus 20-40 parts, Hedyotis diffusa 25-35 parts, Taraxacum mongolicum 20-40 parts, Trichosanthes kirilowii 18-30 parts, Allium macrostemon 20-28 parts, Polygonum cuspidatum 10-20 parts, Perilla frutescens 10-30 parts, Ligusticum chuanxiong 8-16 parts, Glycyrrhiza uralensis 2-10 parts.

3. A method of applying the hot compress pack for treating pulmonary fibrosis according to claim 1, characterized in that: The application of the traditional Chinese medicine composition in the hot compress pack in the preparation of drugs for treating idiopathic pulmonary fibrosis and secondary pulmonary fibrosis includes local hot compress application and oral administration of decoction.

4. The method of applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis according to claim 3, characterized in that: The localized hot compress application specifically includes the following steps: Step A: Heat and activate the hot compress pack; Step B: Pre-treatment of the area to be treated with heat; Step C: Apply the patch to the affected area; Step D: Post-use treatment of the hot compress pack.

5. The method of applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis according to claim 4, characterized in that: In step A, first check that the hot compress pack is intact and that the waterproof layer is sealed, and then gently rub the hot compress pack to distribute the medicine powder evenly. Next, preheat the hot compress pack by heating it at a low temperature in a microwave oven for 1-2 minutes, so that the hot compress pack reaches 40-50 degrees Celsius before use. Step B involves cleaning the area corresponding to the patient's chest and lungs, and keeping that area dry. In step C, during the application process, the preheated hot compress pack is directly adhered to the hot compress area on the skin through the fixing layer. The specific location can be selected at the Feishu acupoint corresponding to the chest and lung area. Light pressure is used to ensure that it adheres to the skin. Before application, the temperature of the hot compress pack needs to be tested by touching it with the back of the hand. During the hot compress process, the heat insulation layer is used to maintain the temperature, and the application time is controlled to 15-30 minutes each time, 1-2 times a day; Step D involves gently peeling off the heat pack after the heat compress time has ended and then gently stroking the skin.

6. The method of applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis according to claim 3, characterized in that: The application of the decoction for warm administration includes the following steps: Step E: Prepare the traditional Chinese medicine composition; Step F: Simmer in the clay pot twice in separate steps; Step G: Specific application of the decoction by warm administration; Step H: Verification of the efficacy of the traditional Chinese medicine combination.

7. The method of applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis according to claim 6, characterized in that: In step E, the following ingredients are prepared in the specified weight proportions: Astragalus membranaceus, Hedyotis diffusa, Taraxacum mongolicum, Trichosanthes kirilowii, Allium macrostemon, Polygonum cuspidatum, Perilla frutescens, Ligusticum chuanxiong, and Glycyrrhiza uralensis. The herbal composition is then washed with water to remove surface impurities. In step F, a clay pot is used as a simmering container, and the decoction is obtained through two simmering processes. During the first decoction, put the washed Chinese herbal medicine mixture into a clay pot, add 1000ml of water, soak for 30 minutes to allow the herbs to fully absorb water, then bring to a boil over high heat, then simmer over low heat for 40 minutes. Use gauze to separate the liquid and dregs to obtain the first decoction. During the second decoction, add 800ml of water to the dregs, bring to a boil over high heat again, then simmer over low heat for 30 minutes. Filter again to obtain the decoction from the first decoction. Combine the decoctions from the two decoctions to obtain 500ml of soup. If the total amount of soup is less than 500ml, add water as needed. If there is too much soup, concentrate it to an appropriate amount. If there are obvious impurities in the soup, it needs to be filtered again.

8. The method of applying a traditional Chinese medicine hot compress pack for treating pulmonary fibrosis according to claim 7, characterized in that: In step G, the obtained decoction is heated and taken in three divided doses, specifically in the morning, noon and evening of the same day, with each dose being 160-170ml, one dose per day, for three consecutive months. In step H, during the verification process, animal experiments were conducted. A rat model of idiopathic pulmonary fibrosis was prepared by intratracheal instillation of bleomycin. On the day after modeling, the rats were administered physiological saline, positive control drug, and Tongbi Huaxianfang (a traditional Chinese medicine formula) at high, medium, and low doses by gavage. Once daily for 28 consecutive days, rats were fasted for 12 hours before sampling but allowed free access to water. The general condition of the rats, lung coefficient, lung tissue pathological section staining, and HYP level were observed using ELISA.

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