一种鸦胆子提取物-虫草素HPV减毒制剂及其制备方法与应用
By combining Brucea javanica extract with cordycepin and using nanotechnology, the prepared HPV attenuation formulation solves the problems of low retention rate of active ingredients and poor transdermal absorption, achieving efficient HPV clearance and local immune enhancement, improving HPV seroconversion rate and CIN reversal rate, and ensuring the safety and stability of the formulation.
CN121570508BActive Publication Date: 2026-07-17SHANGHAI MEIHA BIOTECHNOLOGY DEV CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI MEIHA BIOTECHNOLOGY DEV CO LTD
- Filing Date
- 2025-12-18
- Publication Date
- 2026-07-17
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Figure CN121570508B_ABST
Abstract
本发明公开了一种鸦胆子提取物‑虫草素HPV减毒制剂及其制备方法与应用，具体涉及抗病毒制剂技术及妇科医疗技术领域，按质量百分比计，由以下组分组成：鸦胆子提取物5%‑15%、虫草素0.3%‑1.0%、表面活性剂1%‑3%、促透剂2%‑5%、增稠剂0.5%‑2%、pH调节剂和余量的纯化水；所述pH调节剂的用量为使制剂pH值稳定在4.0‑6.5范围内的用量。本发明通过鸦胆子提取物与虫草素的药理协同，实现直接抗病毒与主动免疫调节的双重功效突破，不仅快速降低了病毒载量，更通过增强机体自身清除能力，从根本上扭转了HPV持续感染的免疫微环境，物理粒径优化与化学促透增强的双重策略协同，确保了高活性的药物成分能够高效渗透并富集于病灶部位，从而显著提升了药效的发挥速度和作用强度。
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