A sterile automated caging and decaging device for the pharmaceutical industry

Abstract

The application relates to a sterile automatic boxing and unboxing device for the pharmaceutical industry, comprising a freeze dryer and a transfer assembly, characterized in that one side of the freeze dryer is provided with a boxing device, and the other side is provided with an unboxing device; the boxing device comprises a mounting seat, an operation box located on the mounting seat, a feeding module, a dial and a discharging table; the boxing device and the unboxing device are matched, the boxing and unboxing efficiency is high, and compared with manual operation, the risk of microbial and particle pollution is reduced.

Description

Technical Field

[0001] This invention relates to a device for storing and temporarily storing medicine bottles, and more specifically to a sterile automated frame-fitting and frame-unloading device for the pharmaceutical industry. Background Technology

[0002] In automated production lines of the pharmaceutical and biological products industries, ampoules are a common type of sealed container used to hold liquid medicines such as injectables and vaccines. Between filling, sealing, testing and packaging processes, ampoules usually need to be arranged in an orderly manner and transferred stably to ensure the continuity and accuracy of subsequent processes.

[0003] Currently, before freeze-drying the drugs in the bottles, the bottles need to be framed and divided into individual frames. However, the existing frame-setting is done from directly above the bottle, which can cause impurities to fall into the bottle, preventing the drugs from meeting the requirements. Moreover, the frame removal is done manually, which is inefficient. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the present invention aims to provide a sterile automated frame-packing and frame-removing device for the pharmaceutical industry, comprising a freeze dryer and a transfer assembly. The freeze dryer is characterized by having a frame-packing device on one side and a frame-removing device on the other. The frame-packing device includes a mounting base, an operation box on the mounting base, a feeding module, a dial, and a discharge platform. The mounting base has an alignment assembly on one side of the dial, and also includes a platform to the right of the alignment assembly, a frame placement rack behind the mounting base, several frames arranged longitudinally on the frame placement rack, a lower frame assembly for lowering the frames at the bottom of the frame placement rack, and a transfer assembly for... The frame feeding assembly moves the frame at the bottom of the frame placement rack to the top of the platform, and the adjusting assembly pushes the frame on the top of the platform forward. The top frame module drives the frame on the platform to slide up and down. The frame removal device includes a frame, a conveying device on the frame for conveying the frames filled with bottles, a placement plate on the frame located on one side of the conveying device and parallel to the conveyor belt of the conveying device, a frame pushing assembly at the output end of the conveyor belt of the conveying device for pushing the frames on the conveyor belt of the conveying device toward the placement plate, a frame removal assembly at one end of the placement plate, and a bottle pushing assembly on the placement plate.

[0005] The invention is further configured such that: the code frame placement frame includes a left plate and a right plate, and a limiting plate is fixedly installed on the rear side of the left plate; the code frame placement frame also includes a code frame baffle located on the front side between the left plate and the rear plate; the limiting plate extends vertically along its length and abuts against the rear end face of each frame; the inner walls of the left and right plates abut against the circumference of each frame; the lower frame assembly includes bases located on the left and right sides of the code frame placement frame and a drive shaft; each drive shaft is rotatably installed in its corresponding base; each drive shaft is provided with a first pagination piece and a second pagination piece on the upper and lower sides of the bottom frame; the opening of the first pagination piece faces rearward, and the opening of the second pagination piece faces forward and abuts against the lower end face of the bottom frame.

[0006] The present invention is further configured such that: a bottle-blocking assembly is provided on one side of the dial, the bottle-blocking assembly includes a bottle-blocking rodless cylinder fixedly mounted on the mounting base, a bottle-blocking seat fixedly connected to the output end of the bottle-blocking rodless cylinder, a motor fixedly mounted on the bottle-blocking seat, and a rotating shaft rotatably mounted on the bottle-blocking seat and fixedly connected to the output shaft of the motor, and a stop rod is fixedly connected to the other end of the rotating shaft.

[0007] The present invention is further configured such that: the frame feeding assembly includes a frame feeding plate, a frame feeding cylinder, and a mating seat that is linked with the frame feeding cylinder; the mating seat is fixedly connected to the frame feeding plate; the frame feeding plate includes a pushing part that abuts against the rear side of the bottom frame; the frame placement rack is provided with guide strips on the left and right sides of the bottom; and each frame bottom is provided with a guide groove corresponding to the guide strip.

[0008] A further embodiment of the present invention is that the top frame module includes top frame plates located on the front and rear sides of the platform and driving components for moving each top frame plate up and down.

[0009] The invention is further configured such that: the adjustment assembly includes a rotating seat, a connecting shaft, a first lifting arm and a second lifting arm rotatably sleeved on the connecting shaft, a first cylinder linked to the first lifting arm and a second cylinder linked to the second lifting arm, a drive cylinder for driving the rotating seat to move forward is installed on the mounting seat, the first lifting arm is located in front of the second lifting arm, a push plate is installed in front of the first lifting arm via a connecting rod, and a linear module for pushing the frame with the medicine bottle sleeved onto the transfer assembly is provided on the mounting seat.

[0010] The present invention is further configured such that: the frame removal assembly includes a frame removal device fixedly mounted on the frame, an electric push rod fixedly mounted on the frame, and a transfer frame movably mounted on the frame; the placement plate has a groove, and a fixing plate is provided in the groove; the fixing plate is spaced apart from the placement plate around its perimeter; the lower end faces of the front and rear sides of the fixing plate are connected to the lower end faces of the placement plate by fixing blocks; the fixing blocks have slots corresponding to the intervals; the left and right sides of the fixing plate are provided with lifting plates adapted to the grooves on the left and right sides of the fixing plate; the lifting plates are connected to the frame by lifting cylinders; a push plate is fixedly connected to the push rod of the electric push rod; the push plate is movably mounted on the frame removal device and the placement plate; cylinders are fixedly mounted on the front and rear sides of the frame removal device; a support plate is fixedly connected to the output end of the cylinder; and the support plate is movably mounted inside the frame removal device.

[0011] A further feature of the present invention is that a material drop trough is provided on the placement plate, and the detachment frame and the transfer frame are located at the material drop trough.

[0012] The present invention is further configured such that: the push frame assembly includes a rodless cylinder fixedly mounted on the frame, a fixed seat fixedly mounted on the rodless cylinder, and a fixed column fixedly mounted in the fixed seat; a front fixed rod and a rear fixed rod are arranged sequentially from front to back on the fixed column; the rear fixed rod is fixedly mounted on the fixed column; the front fixed rod is movably mounted on the fixed column; an electric push rod is fixed in the fixed seat; the electric push rod is connected to the front fixed rod through a fisheye connector; a clearance groove is provided on the conveying frame of the conveying device; and the rear fixed rod is located in the clearance groove.

[0013] The invention is further configured such that: the bottle pushing assembly includes a front rodless cylinder and a rear rodless cylinder fixedly mounted on the frame, the front rodless cylinder and the rear rodless cylinder are respectively located on the front and rear sides of the placement plate, the output ends of the front rodless cylinder and the rear rodless cylinder are fixed with mounting brackets, the mounting brackets are fixed with front mounting columns and rear mounting columns, the front mounting column is rotatably provided with a push bar, a lifting cylinder is provided between the front mounting column and the rear mounting column and fixedly connected to the mounting bracket, and the piston rod of the lifting cylinder is connected to the push bar through a fisheye connector.

[0014] By adopting the above technical solution, when the bottles are transported to the aligning and bottle-blocking components via a dial, the lower frame component is activated to lower the sleeve frame. Then, the feeding frame component pushes the sleeve frame at the bottom onto the platform. The platform has a groove that matches the sleeve frame. The sleeve frame pushed onto the platform will be above the groove. Then, the top frame module is activated, causing the sleeve frame to move down. At this time, the bottle-blocking component pushes all the aligned bottles onto the sleeve frame on the platform (only one-quarter of the sleeve frame size can be pushed at a time, requiring multiple alignments and multiple pushes to fill the sleeve frame on the platform). Then, the top frame module rises, placing the sleeve frame onto the bottle, and then the adjustment group is activated. The process involves pushing the frame containing the bottle to the discharge platform, then using a linear module and a horizontal plate to push the frame onto a transfer assembly. The transfer assembly then sends the frame to a freeze dryer for freeze drying. After freeze drying, the frame is pushed onto a conveyor via a pushing component on the transfer assembly. The conveyor then transports the frame to a frame-pushing assembly, where it is pushed onto a placement plate. The frame is then removed from the bottle by a frame-removing component on the placement plate, separating the frame from the bottle. Finally, a bottle-pushing assembly pushes the bottle to the next process. This process is highly efficient and requires no human contact. The combination of the frame-filling and frame-removing devices ensures high frame loading and unloading efficiency, reducing the risk of microbial and particulate contamination compared to manual operation. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is an assembly diagram of a specific embodiment of the sleeve frame device of the present invention;

[0017] Figure 2 This is a perspective view of the frame device of the present invention from a right-to-left perspective;

[0018] Figure 3 This is a cross-sectional view of the sleeve device of the present invention;

[0019] Figure 4 for Figure 2 Enlarged view of A in the middle;

[0020] Figure 5 for Figure 2 Enlarged view of B in the middle;

[0021] Figure 6 for Figure 3 Enlarged view of C in the middle;

[0022] Appendix Figure 7 This is a schematic diagram of the frame release device;

[0023] Appendix Figure 8 This is a bottom view of the frame-detaching device.

[0024] Appendix Figure 9 for Figure 8 A magnified structural diagram of D in the diagram. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0026] like Figures 1-9As shown, this invention discloses an aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry, including a freeze dryer (prior art) and a transfer assembly (prior art). The freeze dryer is characterized by having a frame-fitting device on one side and a frame-unfitting device on the other. The frame-fitting device includes a mounting base 111, an operation box 121 located on the mounting base 111, a feeding module 131, a dial 141, and a discharge platform 161. The mounting base 111 has an alignment assembly 1711 and a bottle-blocking assembly on one side of the dial 141. The alignment assembly 1711 includes a pusher cylinder 171, a pusher plate 172, and a vertical plate 173 slidably mounted on the mounting base 111. The mounting base 111 has a channel 151 for the passage of medicine bottles. The assembly also includes a transfer plate 173 located on the alignment assembly. The platform 1111 on the right side of 1711 includes a frame placement rack 330 located behind the mounting base 111, several longitudinally arranged frames 331 on the frame placement rack 330, a lower frame assembly 40 for lowering the frames 331 at the bottom of the frame placement rack 330, a frame feeding assembly 50 for moving the frames 331 at the bottom of the frame placement rack 330 to above the platform 1111, an adjusting assembly 60 for pushing the frames 331 above the platform 1111 forward, and a top frame module 210 for pushing the frames on the platform upward. The frame removal device includes a frame, a placement plate 3 mounted on the frame 1 and located on one side of the conveyor device and parallel to the conveyor belt of the conveyor device 2, and the output of the conveyor belt of the conveyor device. At one end, a pusher assembly 4 pushes the sleeve frames on the conveyor belt of the conveyor device towards the placement plate 3. One end of the placement plate 3 is equipped with a detacher assembly 5, and a bottle pusher assembly 666 is also provided on the placement plate 3. When the bottles are conveyed to the aligning assembly and the bottle-blocking assembly via a dial, the lower frame assembly is activated to lower the sleeve frames. Then, the feeding frame assembly pushes the sleeve frames at the bottom onto the platform. The platform has grooves that match the sleeve frames. The sleeve frames pushed onto the platform will be above the grooves. Then, the top frame module is activated, causing the sleeve frames to move downwards. At this time, the bottle-blocking assembly pushes all the aligned bottles towards the sleeve frames on the platform (only one-quarter of the sleeve frame size can be pushed at a time; multiple alignments and pushes are required to fill the sleeve frames on the platform). Then, the top frame module rises and places the frame onto the bottle. The adjusting component then pushes the frame with the bottle on it to the discharge platform. The frame is then pushed onto the transfer component by the cooperation of the linear module and the horizontal plate. The transfer component sends the frame to the freeze dryer for freeze drying. After freeze drying, the frame is pushed onto the conveyor by the pushing component on the transfer component. The conveyor then transports the frame to the frame pushing component, which pushes the frame onto the placement plate. The frame removal component on the placement plate removes the frame, separating it from the bottle. The bottle pushing component then pushes the bottle to the next process. This process is highly efficient and requires no human contact. The combination of the frame-fitting and frame-removing devices ensures high frame loading and unloading efficiency, reducing the risk of microbial and particulate contamination compared to manual operation.

[0027] The code frame placement frame 330 includes a left plate 332 and a right plate 33. A limiting plate 321 is fixedly installed on the rear side of the left plate 332 by means of integral molding or other methods. The code frame placement frame 330 also includes a code frame baffle 34 located on the front side between the left plate 332 and the rear plate. The limiting plate 321 extends vertically along its length and abuts against the rear end face of each frame 331. The inner walls of the left plate 332 and the right plate 33 abut against the circumference of each frame 331. Due to the limiting... The presence of plate 321 and frame baffle 34 ensures that after several frames 331 are inserted downwards from the top space between the left plate 332 and the right plate 33, the front side of each frame 331 is restricted by the frame baffle 34 and the rear side is restricted by the positioning plate 321. Therefore, without the action of external force, each frame 331 can be stably positioned between the left plate 332 and the right plate 33 and cannot fall or move forward. After the lower frame assembly 40 is activated, only the topmost frame 331 can be moved downwards.

[0028] A bottle-blocking assembly is also provided on one side of the dial. The bottle-blocking assembly includes a bottle-blocking rodless cylinder 101 fixedly mounted on the mounting base 111, a bottle-blocking seat 102 fixedly connected to the output end of the bottle-blocking rodless cylinder 101, a motor (not shown) fixedly mounted on the bottle-blocking seat 102, and a rotating shaft 103 rotatably mounted on the bottle-blocking seat 102 and fixedly connected to the output shaft of the motor. A stop rod 104 is fixedly connected to the other end of the rotating shaft 103. At this time, a vertical plate 173 is slidably mounted on one end of the dial 141. The vertical plate is higher than the upper surface of the platform. A vertical plate cylinder (not shown) is fixedly mounted on the mounting base for driving the vertical plate to move up and down. Then the bottle-blocking assembly is activated, driving the stop rod to rotate. The platform rotates to create an interval between the stop bar and the pusher plate. A dial conveyor transports medicine bottles into the interval. Once the interval is full, the dial stops, the stop bar rotates upwards, and the pusher cylinder moves the pusher plate, pushing the bottles towards the upright plate. At this point, the bottles exceed the position of the stop bar (when the stop bar rotates towards the platform and is level with it). This process is repeated, and more and more bottles accumulate between the stop bar and the upright plate (two or three groups). Then, the upright plate cylinder lowers, bringing the stop bar parallel to the platform. The bottle-blocking cylinder then activates, pushing all the bottles between the stop bar and the upright plate onto the platform. After repeating this process multiple times, the frame on the platform is filled with bottles, facilitating bottle pushing.

[0029] The lower frame assembly 40 includes bases 41 located on the left and right sides of the code frame placement frame 330 and drive shafts 42. Each drive shaft 42 is rotatably mounted in its corresponding base 41. Each drive shaft 42 has a first pagination piece 421 and a second pagination piece 422 located on the upper and lower sides of the bottom sleeve 331, respectively. The first pagination piece and the second pagination piece are staggered. The opening of the first pagination piece 421 faces rearward, and the opening of the second pagination piece 422 faces forward and abuts against the lower end face of the bottom sleeve 331. When it is necessary to move the bottom sleeve 331 of the code frame placement frame 330 downward, each drive shaft is rotated 180° to achieve the desired position. The second page 422 above the bottom frame 331 changes from being abutted against the lower end face of the bottom frame 331 to separating from the lower end face of the bottom frame 331. After the bottom frame 331 falls, the first page 421 abuts against the bottom of the frame 331 located above the bottom frame 331 to prevent it from falling continuously. At this time, after rotating 180° clockwise, the second page 422 is away from the frame. When rotating 180° again, the upper end face of the second page 422 abuts against the bottom of the frame. In this way, the frames 331 located on the frame placement rack 330 can be moved down one by one when they need to fall, avoiding multiple frames 331 falling at the same time and causing jamming or blocking.

[0030] The frame feeding assembly 50 includes a frame feeding plate 51, a frame feeding cylinder 52, and a mating seat 53 that is linked to the frame feeding cylinder 52. The movable end of the frame feeding cylinder is fixedly connected to the mating seat. The mating seat 53 is fixedly connected to the frame feeding plate 51 by welding or other means. The frame feeding plate 51 includes a pushing part 511 that abuts against the rear side of the bottom frame 331. After the frame 331 is lowered, the frame feeding cylinder 52 is activated, which can drive the mating seat 53 and the frame feeding plate 51 connected to the mating seat 53 to move forward. Since the pushing part 511 of the frame feeding plate 51 abuts against the rear side of the frame 331, it pushes the frame 331 forward and pushes the frame onto the platform 1111.

[0031] A further feature of the present invention is that the frame placement rack 330 is provided with guide strips 35 on the left and right sides between the bottom left plate 332 and the right plate 33, and each frame 331 is provided with a guide groove 311 at the bottom of the guide strip 35. When the frame feeding cylinder 52 is activated and the frame feeding plate 51 is moved forward, the frame 331 moving forward can slide smoothly along the guide strip 35. Therefore, each guide strip 35 can restrict and guide the movement path of the frame 331 moving forward.

[0032] The top frame module 210 includes top frame plates 211 located on the front and rear sides of the platform 1111 and a drive unit 212 for moving each top frame plate 211 up and down. Each top frame plate 211 is located directly below and abuts against the front and rear side plates of the sleeve frame 331. When the medicine bottles, after being fully aligned, enter the sleeve frame 331 under the action of the bottle-blocking rodless cylinder and the blocking rod 104, the drive unit 212 (which can be a cylinder, a motor that works with a lead screw / guide rail, or a linear motor) is activated to drive the top frame plates 211 located below the platform 1111 to move upward. As the top frame plates 211 move upward, the sleeve frame 331 moves upward to cover the medicine bottles. The upper surface of the top frame plate is flush with the upper surface of the platform. Then, the adjustment component is activated to push the sleeve frame filled with medicine bottles.

[0033] The invention is further configured such that the adjusting assembly 60 includes a rotating seat 61, a connecting shaft 62, a first lifting arm 63 and a second lifting arm 64 rotatably fitted onto the connecting shaft 62, a first cylinder 65 linked to the first lifting arm 63, and a second cylinder 66 linked to the second lifting arm 64. The first cylinder and the second cylinder are respectively connected to the first lifting arm and the second lifting arm via a fisheye connector. A driving cylinder 181 for driving the rotating seat 61 to move forward is mounted on the mounting base. The first lifting arm 63 is located in front of the second lifting arm 64. A push plate 631 is mounted in front of the first lifting arm 63 via a connecting rod. When the sleeve 331 containing the medicine bottle moves upward, the second lifting arm is rotated by activating the second cylinder 66. The downward-bent end of the second lifting arm is located behind the sleeve 331. During the process of activating the driving cylinder 181 to drive the rotating seat 61 to move forward, the second lifting arm 64 can push the sleeve 331 towards... After moving forward and completing the first stage of pushing, the rotating seat 61 retracts, and the second lifting arm 64 lifts. Similarly, after retracting, the first cylinder 65 drives the first lifting arm 63 to swing down, so that the push plate 631 is located behind the sleeve frame. Moving the rotating seat 61 forward again allows the first lifting arm 63 and the push plate 631 to push the sleeve frame 331 forward. The two lifting arms can share the thrust and extend the service life, and the alternating push can achieve long-distance transportation. The mounting seat is provided with a linear module 67 for pushing the frame with the medicine bottle on it to the transfer component. A horizontal plate is fixedly connected to the output end of the linear module. The linear module can easily drive the horizontal plate to push the frame with the medicine bottle on it out of the discharge platform and then push it onto the transfer component. The transfer component transports the frame with the medicine bottle on it to the freeze dryer to freeze dry the medicine. After freezing, the freeze-dried medicine and the sleeve frame are transported to the conveying device on the frame removal device through the transfer component. The frame removal device removes the frame.

[0034] A further configuration of the present invention is that the frame removal assembly 5 includes a frame removal frame 6 fixedly mounted on the frame 1, an electric push rod 7 fixedly mounted on the frame 1, and a transfer frame 8 movably mounted on the frame 1. The transfer frame is movably mounted on the frame to facilitate movement after the frame is filled. The placement plate 3 has a groove 9, and a fixing plate 10 is provided within the groove 9. The fixing plate 10 is spaced apart from the placement plate 3 around its perimeter, allowing the frame to fall below the placement plate and facilitating separation of the frame from the bottle. The lower ends of the front and rear sides of the fixing plate 10 are connected to the lower ends of the placement plate 3 via fixing blocks 11. The fixing blocks 11 have slots 12 corresponding to the spacing, which serve as limiting positions. The left and right sides of the fixing plate 10 have grooves that match the left and right sides of the fixing plate 10. The lifting plate 13 is connected to the frame 1 via a lifting cylinder 14. The lifting cylinder and the lifting plate are designed to facilitate the up-and-down movement of the sleeve frame. A push plate 15 is fixedly connected to the push rod of the electric push rod 7. The push plate 15 is movably mounted on the ejector frame 6 and the placement plate 3. When the sleeve frame is located in the groove of the placement plate, the push plate is used to transport the bottle to the bottle pushing assembly. When the sleeve frame is located on the placement plate, the push plate is pulled back, causing the sleeve frame to move towards the ejector frame. Cylinders 16 are fixed on the front and rear sides of the ejector frame 6. A support plate 17 is fixedly connected to the output end of the cylinder 16. The support plate 17 is movably mounted inside the ejector frame 6. The support plate serves as a transition when the push plate pulls the sleeve frame back, ensuring that the sleeve frame is inside the ejector frame. Then, the cylinder is activated, and the two support plates move away from each other.

[0035] A further feature of the present invention is that a material drop trough 18 is provided on the placement plate 3, and the frame removal frame and the transfer frame are located at the material drop trough, so that the frame can fall onto the transfer frame.

[0036] A further configuration of the present invention is that the push frame assembly 4 includes a rodless cylinder 19 fixedly mounted on the frame 1, a fixed seat 20 fixedly mounted on the rodless cylinder 19, and a fixed column 21 fixedly mounted within the fixed seat 20. The fixed column 21 has a front fixed rod 22 and a rear fixed rod 23 arranged sequentially from front to back. The rear fixed rod 23 is fixedly mounted on the fixed column 21, and the front fixed rod 22 is movably mounted on the fixed column 21. An electric push rod 24 is fixed within the fixed seat 20. The electric push rod 24 is connected to the front fixed rod 22 via a fisheye connector. The arrangement of the front and rear fixed rods allows for supplementary strokes when the rear fixed rod has a short travel distance, facilitating the pushing of the frame onto the placement plate. The conveyor frame of the conveying device has a clearance groove 25, and the rear fixed rod 23 is located within the clearance groove 25. By placing the rear fixed rod within the clearance groove, space is saved, and it is convenient to push the frame onto the placement plate.

[0037] A further configuration of the present invention is that the bottle-pushing assembly 666 includes a front rodless cylinder 26 and a rear rodless cylinder 27 fixedly mounted on the frame 1. The front rodless cylinder 26 and the rear rodless cylinder 27 are respectively located on the front and rear sides of the placement plate 3. A mounting bracket 28 is fixed to the output end of the front rodless cylinder 26 and the rear rodless cylinder 27. A front mounting post 29 and a rear mounting post 30 are fixed on the mounting bracket 28. A pusher strip 31 is rotatably mounted on the front mounting post 29. A connection is provided between the front mounting post 29 and the rear mounting post 30 to the mounting bracket 28. The lifting cylinder 32 is connected, and the piston rod of the lifting cylinder 32 is connected to the push bar 31 through a fisheye connector. When the lifting cylinder on the front rodless cylinder is activated, it drives the push bar to move. The push bar is parallel to the placement plate. The front rodless cylinder activates and drives the push bar to transport the medicine bottle. Then the front rodless cylinder resets. Then the lifting cylinder on the rear rodless cylinder is activated and drives the push bar to move. The push bar is parallel to the placement plate. The rear rodless cylinder activates and drives the push bar to continue transporting the medicine bottle. If the stroke of the front rodless cylinder is not long, the rear rodless cylinder will supplement and continue to transport the medicine bottle.

[0038] Working principle of the invention:

[0039] The principle of the frame assembly: After the medicine bottle is placed into the feeding module on the mounting base, the operation box controls the various components. Specifically, after startup, the conveyor belt on the mounting base moves, causing the medicine bottle to move towards the channel on the mounting base and reach the dial plate. At this time, a vertical plate is slidably mounted on one end of the dial plate, which is higher than the surface of the platform. A vertical plate cylinder (not shown in the figure) is fixedly mounted on the mounting base to drive the vertical plate to move up and down. Then, the bottle blocking assembly is activated, causing the blocking rod to rotate towards the platform, setting the blocking rod and the pusher plate at intervals. The dial plate transports the medicine bottle into the interval. After the interval is filled with medicine bottles, the dial plate stops moving, the blocking rod rotates upward, and the pusher cylinder pushes the pusher plate to move, placing the medicine bottle... Push the bottle towards the upright plate. At this point, the bottle exceeds the position of the stop lever (the position where the stop lever rotates towards the platform and is level with the platform). Repeat the above operation. More and more bottles will accumulate between the stop lever and the upright plate (two or three groups). Then, the upright plate cylinder drives the upright plate cylinder to descend. At this time, the stop lever rotates and lowers to be parallel to the platform. The bottle-blocking rodless cylinder is activated, pushing all the bottles between the stop lever and the upright plate onto the platform via the stop lever (when pushing the bottles onto the platform, the sleeve frame is located in the slot of the platform, i.e., above the top frame module). The sleeve frame at the bottom of the stacking frame moves downward. By causing each drive shaft to rotate 180°, the second page piece located above the bottom sleeve frame changes from being abutted against the lower end face of the bottom sleeve frame to separating from the lower end face of the bottom sleeve frame, while the first page... After the medicine bottle falls to the bottom of the frame, it abuts against the bottom of the frame above it to prevent it from falling continuously. Then, the feeding cylinder is activated, which moves the mating seat and the feeding plate connected to the mating seat forward. Because the pushing part of the feeding plate abuts against the rear side of the frame, it pushes the frame forward and pushes it onto the platform, above the top frame module. Then, the drive unit is activated, which moves the top frame plate down and simultaneously moves the frame down, so that the upper surface of the frame is flush with the platform. Then, the bottle-stopping rodless cylinder is activated, which pushes all the bottles between the stop rod and the upright plate onto the platform via the stop rod. When the platform frame is full of medicine bottles, the top frame module is activated, which moves the frame upward, trapping the medicine bottles in the frame. The upper end of the top frame plate is flush with the upper end of the platform. Then, the drive unit is activated. The adjusting component pushes the frame filled with medicine bottles. Activating the second cylinder rotates the second lifting arm, with its downward-curving end positioned behind the frame. Simultaneously, activating the drive cylinder moves the rotating seat forward, pushing the frame forward. After the first push, the rotating seat retracts, and the second lifting arm rises. Following this retraction, the first cylinder lowers the first lifting arm, positioning the push plate behind the frame. Moving the rotating seat forward again causes the first lifting arm and push plate to push the frame forward onto the discharge platform. The linear module and horizontal plate then push the frame off the discharge platform and onto the transfer component. The transfer component transports the frame with the medicine bottles to the freeze dryer for freeze-drying. After freeze-drying…The lyophilized drug and its frame are transported via a transfer assembly to a frame removal device, where the frame is removed.

[0040] The working principle of the frame removal device: The freeze-dried medicine and the frame are transported to the conveyor on the frame removal device via the transfer component. The conveyor transports the frame filled with medicine bottles to the frame pushing component. The conveyor stops moving, and then the servo module is activated to push the frame towards the placement plate via the rear fixing rod. Due to the short stroke of the rear fixing rod, the servo module drives the fixing seat to move backward. Then, the electric push rod drives the front fixing rod to move downward, parallel to the conveyor frame of the conveyor. Then, the servo module drives the front fixing rod to push the frame onto the placement plate (at this time, the lifting plate is flush with the upper surface of the placement plate). Then, the lifting cylinder is activated, driving the lifting plate to move downward, causing the frame to fall from the groove into the slot of the fixing block, with the upper surface of the frame flush with the placement plate. Then, the electric actuator starts, driving the pusher plate to move. The pusher plate pushes the bottle to the bottle pushing assembly. Then, the lifting cylinder starts, driving the lifting plate to move upward (at the same time, the cylinder drives the pallet to move, bringing the two pallets closer together). The lifting plate is level with the placement plate. Then, the electric actuator starts, driving the pusher plate to move back, pulling the frame onto the pallet. Then, the cylinder drives the two pallets to move away from each other, and the frame falls onto the transfer frame, completing the frame removal. Then, the lifting cylinder on the front servo module starts, driving the pusher bar to move. The pusher bar is parallel to the placement plate. The front servo module starts, driving the pusher bar to transport the medicine bottle. Then, the front servo module resets. Then, the lifting cylinder on the rear servo module starts, driving the pusher bar to move. The pusher bar is parallel to the placement plate. The rear servo module starts, driving the pusher bar to continue transporting the medicine bottle.

[0041] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A sterile automated crating and uncrewing device for the pharmaceutical industry, comprising a freeze dryer and a transfer assembly, characterized in that: The freeze dryer has a frame-sleeving device on one side and a frame-removing device on the other side. The frame-sleeving device includes a mounting base, an operation box on the mounting base, a feeding module, a dial, and a discharge platform. The mounting base has an alignment assembly on one side of the dial, and also includes a platform to the right of the alignment assembly, a frame-stacking rack behind the mounting base, several frames arranged longitudinally on the frame-stacking rack, a lower frame assembly for lowering the frames at the bottom of the frame-stacking rack, a frame-feeding assembly for moving the frames at the bottom of the frame-stacking rack to the top of the platform, an adjustment assembly for pushing the frames on the top of the platform forward, and a top frame module for moving the frames on the platform up and down. The frame-removing device includes a frame and a component mounted on the frame. A conveying device is provided for conveying frames filled with bottles. The frame is provided with a placement plate located on one side of the conveying device and parallel to the conveyor belt of the conveying device. At the output end of the conveyor belt of the conveying device, there is a frame pusher assembly that pushes the frames on the conveyor belt of the conveying device toward the placement plate. One end of the placement plate is provided with a frame release assembly. The placement plate is provided with a bottle pusher assembly. A bottle stop assembly is also provided on one side of the dial. The bottle stop assembly includes a bottle stop rodless cylinder fixedly mounted on a mounting base, a bottle stop seat fixedly connected to the output end of the bottle stop rodless cylinder, a motor fixedly mounted on the bottle stop seat, and a rotating shaft rotatably mounted on the bottle stop seat and fixedly connected to the output shaft of the motor. A stop rod is fixedly connected to the other end of the rotating shaft.

2. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 1, characterized in that: The code frame placement frame includes a left plate and a right plate, with a limiting plate fixedly installed on the rear side of the left plate. The code frame placement frame also includes a code frame baffle located on the front side between the left plate and the rear plate. The limiting plate extends vertically along its length and abuts against the rear end face of each frame. The inner walls of the left and right plates abut against the circumference of each frame. The lower frame assembly includes bases located on the left and right sides of the code frame placement frame and drive shafts. Each drive shaft is rotatably installed in its corresponding base. Each drive shaft has a first pagination piece and a second pagination piece on its upper and lower sides of the bottom frame. The opening of the first pagination piece faces rearward, and the opening of the second pagination piece faces forward and abuts against the lower end face of the bottom frame.

3. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 1, characterized in that: The frame feeding assembly includes a frame feeding plate, a frame feeding cylinder, and a mating seat that is linked to the frame feeding cylinder. The mating seat is fixedly connected to the frame feeding plate. The frame feeding plate includes a pushing part that abuts against the rear side of the bottom frame. The frame placement rack is provided with guide strips on the left and right sides of the bottom, and each frame bottom is provided with a guide groove corresponding to the guide strip.

4. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 1, characterized in that: The top frame module includes top frame plates located on the front and rear sides of the platform and driving components for moving each top frame plate up and down.

5. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 1, characterized in that: The adjustment assembly includes a rotating seat, a connecting shaft, a first lifting arm and a second lifting arm that are rotatably fitted onto the connecting shaft, a first cylinder that is linked to the first lifting arm and a second cylinder that is linked to the second lifting arm. A drive cylinder for moving the rotating seat forward is installed on the mounting seat. The first lifting arm is located in front of the second lifting arm. A push plate is installed in front of the first lifting arm via a connecting rod. A linear module for pushing the frame with the medicine bottle fitted onto it toward the transfer assembly is provided on the mounting seat.

6. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 1, characterized in that: The frame removal assembly includes a frame removal device fixedly mounted on the frame, an electric push rod fixedly mounted on the frame, and a transfer frame movably mounted on the frame. The placement plate has grooves, and a fixing plate is placed within the grooves. The fixing plate is spaced apart from the placement plate around its perimeter. The lower ends of the front and rear sides of the fixing plate are connected to the lower ends of the placement plate via fixing blocks. The fixing blocks have slots corresponding to the intervals. Lifting plates, matching the grooves on the left and right sides of the fixing plate, are provided on the left and right sides of the fixing plate. The lifting plates are connected to the frame via lifting cylinders. A push plate is fixedly connected to the push rod of the electric push rod, and the push plate is movably mounted on the frame removal device and the placement plate. Cylinders are fixedly mounted on the front and rear sides of the frame removal device, and a support plate is fixedly connected to the output end of each cylinder. The support plate is movably mounted within the frame removal device.

7. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 6, characterized in that: The placement plate is provided with a material drop chute, and the detachment frame and transfer frame are located at the material drop chute.

8. The aseptic automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 7, characterized in that: The push frame assembly includes a rodless cylinder fixedly mounted on the frame, a fixed seat fixedly mounted on the rodless cylinder, and a fixed column fixedly mounted inside the fixed seat. The fixed column has a front fixed rod and a rear fixed rod arranged sequentially from front to back. The rear fixed rod is fixedly mounted on the fixed column, and the front fixed rod is movably mounted on the fixed column. An electric push rod is fixed inside the fixed seat. The electric push rod is connected to the front fixed rod through a fisheye connector. The conveying frame of the conveying device has a clearance groove, and the rear fixed rod is located in the clearance groove.

9. A sterile automated frame-fitting and frame-unfitting device for the pharmaceutical industry according to claim 8, characterized in that: The bottle pushing assembly includes a front rodless cylinder and a rear rodless cylinder fixedly mounted on the frame. The front rodless cylinder and the rear rodless cylinder are located on the front and rear sides of the placement plate, respectively. A mounting frame is fixed on the output end of the front rodless cylinder and the rear rodless cylinder. A front mounting column and a rear mounting column are fixed on the mounting frame. A push bar is rotatably mounted on the front mounting column. A lifting cylinder is fixedly connected to the mounting frame between the front mounting column and the rear mounting column. The piston rod of the lifting cylinder is connected to the push bar through a fisheye connector.

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