Anti-caking D-ribose drying processing method

Abstract

The invention relates to the technical field of biochemical engineering, and provides an anti-caking D-ribose drying processing method which comprises the following steps: step 1, dehydrating wet D-ribose crystals obtained by a microbial conversion method through a centrifugal draining machine, and removing a free solvent on the surface to obtain a filter cake-shaped material; 2, air for drying is sequentially subjected to impurity removal through a primary filter, compression through an air compressor, cooling through a cooler and oil removal and water removal through a cyclone separator, deep dehumidification is conducted through a freezing dryer, the pressure is adjusted to 4.0-8.0 KPa through an adjusting valve, and the temperature is increased to 35-50 DEG C through a heater. By controlling the temperature and the humidity of drying air and preparing a special anti-blocking agent, the blocking rate is greatly reduced, and the blocking problem is solved; low-temperature rapid drying is achieved, melting is prevented, closed filtering is achieved, pollution is reduced, and purity and sanitation are guaranteed; fluidization drying improves efficiency, and tail gas recovery reduces loss; the anti-blocking agent and parameters can adapt to multiple scenes, can also be migrated to other saccharide processing, and has wide application value.

Description

Technical Field

[0001] This invention relates to the field of biochemical technology, specifically to a method for drying and processing D-ribose to prevent clumping. Background Technology

[0002] D-ribose, an important pentose monosaccharide, is widely used in food, medicine, cosmetics, and other fields. Its production often employs microbial transformation, involving fermentation, filtration, and crystallization. The moist crystals then need to be dried to obtain a qualified powder product. The drying process directly affects the purity, stability, and performance of D-ribose; preventing clumping is a key technical requirement in the drying process.

[0003] Existing D-ribose drying technologies mainly fall into two categories: one is airflow drying, which rapidly dehydrates the powder using high-temperature air, but D-ribose has a low melting point, and high temperatures can easily cause it to melt and stick together; the other is conventional dehumidification drying, which, while able to control temperature, lacks precise control over the humidity of the drying air and specific anti-caking measures. Some technologies involve sieving after drying, but this does not solve the problem of moisture absorption and clumping during powder storage, making it difficult to meet the needs of large-scale production and long-term storage.

[0004] Existing technologies have significant drawbacks: high-temperature drying easily leads to the melting and clumping of D-ribose, while low-temperature drying results in incomplete dehumidification of the air, leading to high residual humidity in the product and easy clumping after moisture absorption; there is a lack of anti-caking solutions adapted to the characteristics of D-ribose, and simple sieving cannot fundamentally solve the clumping problem; the connection between drying and subsequent processing is not airtight, and the intrusion of external moisture exacerbates clumping; some technologies fail to control impurities and microbial contamination during the drying process, affecting product quality and making it difficult to meet the comprehensive requirements of drying efficiency, anti-caking effect, and product purity. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a method for drying D-ribose to prevent caking, solving the defects of existing D-ribose drying technologies: high-temperature drying easily leads to melting and caking, while low-temperature drying results in high residual humidity and easy moisture absorption and caking due to incomplete air dehumidification; there is a lack of suitable anti-caking solutions, and simple sieving cannot fundamentally solve the problem; the processing links are not airtight, and the intrusion of external moisture exacerbates caking and easily leads to impurities and microbial contamination, making it difficult to balance efficiency, anti-caking, and purity.

[0006] To achieve the above objectives, the present invention provides a method for drying D-ribose to prevent clumping, comprising the following steps: Step 1: The moist D-ribose crystals obtained by microbial transformation are dehydrated by centrifugal filter dryer to remove free solvent on the surface and obtain filter cake material; Step 2: The drying air is sequentially passed through a pre-filter to remove impurities, compressed by an air compressor, cooled by a cooler, and degreased by a cyclone separator. Then, it is deeply dehumidified by a refrigerated dryer. The pressure is adjusted to 4.0-8.0 kPa by a regulating valve, and the temperature is raised to 35-50°C by a heater. Finally, it is filtered through a 0.3 μm pre-filter and a 0.01 μm sterile filter to obtain dry air with a relative humidity of 1.0%-2.5%. Step 3: The pretreated filter cake-like D-ribose is fed into a drying column, and drying air is introduced from the bottom of the column. The material-to-air mixing ratio is (4:1) to (7:1). The material is fluidized and suspended with the airflow. The drying time is 1-4 seconds to achieve rapid dehydration. At the outlet of the drying column, an anti-caking agent is evenly sprayed onto the dried D-ribose powder. The spraying amount is 0.1%-0.3% of the material mass. Step 4: Feed the D-ribose powder containing anti-caking agent into a particle size sieve to screen out qualified powder with a particle size of 100-200μm. The qualified powder is cooled to room temperature by a cooler and then sent to a sealed moisture-proof storage tank. The storage tank is equipped with a nitrogen protection device, and the humidity, temperature and pressure of the dry air are monitored in real time. The dew point temperature of the refrigerated dryer and the power of the heater are adjusted by a PLC system. Step 5: The entire drying process uses a closed equipment connection to prevent external moisture and impurities from entering. After drying, the powder is tested for microorganisms. Based on the type of solvent residue in D-ribose crystallization, the compound ratio of silica and maltodextrin in the anti-caking agent is adjusted. Finally, the finished D-ribose powder is tested for agglomeration.

[0007] Preferably, in step one, the centrifugal filter dryer operates at a speed of 3000-5000 rpm and a dehydration time of 10-15 minutes, which is used to loosen the filter cake structure and achieve subsequent drying.

[0008] Preferably, in step two, after the air is deeply dehumidified by the refrigerated dryer, the air is heated by the heater at a rate of 5-10℃ / min.

[0009] Preferably, in step three, a guide plate is installed inside the drying column to guide the airflow to form a spiral upward flow, thereby extending the contact time between the material and the air.

[0010] Preferably, in step four, the anti-caking agent is sprayed by atomization, with an atomized particle size of 5-10 μm, and the anti-caking agent is uniformly mixed with the powder by airflow stirring.

[0011] Preferably, in step four, the inner wall of the sealed moisture-proof storage tank is coated with polytetrafluoroethylene to prevent powder adsorption and adhesion, and the gas flow rate for nitrogen protection is 0.1-0.2 m³ / h.

[0012] Preferably, in step four, the monitoring frequency of the PLC system is 1 time / second, and when the relative humidity of the dry air exceeds 2.5%, the power adjustment of the refrigerated dryer is automatically triggered.

[0013] Preferably, in step four, the large particles on the screen are fed into a grinder for crushing and then returned to the screener.

[0014] Preferably, in the compound system of the anti-caking agent in step five, the particle size of food-grade silica is 5-20 nm, and the DE value of maltodextrin is 10-20.

[0015] Preferably, in step five, the ratio of solvent residues is 1:2 when alcohols are the main component and 1:4 when ketones are the main component.

[0016] This invention provides a method for drying D-ribose to prevent clumping. It has the following beneficial effects: 1. This invention, by precisely controlling the humidity and temperature of the dry air and combining it with a special anti-caking agent compound system, addresses both dehydration and anti-adhesion aspects, significantly reducing the agglomeration rate of D-ribose powder during long-term storage in a normal temperature and high humidity environment.

[0017] 2. This invention employs a low-temperature rapid drying mode to avoid the deterioration of D-ribose, while the closed processing and two-stage filtration system reduce impurities and microbial contamination.

[0018] 3. This invention uses fluidized bed drying to ensure full contact between the material and the drying air, reducing the drying time to the second level. Combined with a tail gas recovery system, it reduces material waste and improves drying efficiency, making it suitable for large-scale production needs.

[0019] 4. The compound ratio of the anti-caking agent of the present invention can be flexibly adjusted according to the type of solvent residue in D-ribose crystallization, adapting to the product characteristics of different production processes. Furthermore, the anti-caking drying approach can be transferred to the processing of other highly hygroscopic sugars, demonstrating an application range beyond expectations. Attached Figure Description

[0020] Figure 1 This is a perspective view of the present invention. Detailed Implementation

[0021] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example

[0022] Please see the appendix Figure 1 This invention provides a method for drying D-ribose to prevent clumping, comprising the following steps: Step 1: The moist D-ribose crystals obtained by microbial transformation are dehydrated by a centrifugal filter dryer to remove the free solvent on the surface, resulting in a filter cake material. The speed of the centrifugal filter dryer is 3000-5000 rpm, and the dehydration time is 10-15 minutes. This is used to loosen the structure of the filter cake for subsequent drying. Step 2: The air for drying is sequentially passed through a pre-filter to remove impurities, compressed by an air compressor, cooled by a cooler, and degreased and dehydrated by a cyclone separator. After deep dehumidification by a refrigerated dryer, the air is heated by a heater at a rate of 5-10℃ / min, and the pressure is adjusted to 4.0-8.0KPa by a regulating valve. The heater is then heated to 35-50℃. Finally, the air is filtered through a 0.3μm pre-filter and a 0.01μm sterile filter to obtain dry air with a relative humidity of 1.0%-2.5%. Step 3: The pretreated filter cake-like D-ribose is fed into a drying column. A guide plate is installed inside the drying column to guide the airflow into a spiral upward flow, extending the contact time between the material and the air. Drying air is introduced from the bottom of the column. The material is fluidized and suspended under the action of the spiral airflow, making full contact with the drying air. The mixing ratio of material to air is (4:1) to (7:1). The material is fluidized and suspended with the airflow. The drying time is 1-4 seconds to achieve rapid dehydration. At the outlet of the drying column, an anti-caking agent is evenly sprayed onto the dried D-ribose powder. The spraying amount is 0.1%-0.3% of the material mass. Step 4: Feed the D-ribose powder containing the anti-caking agent into a particle size separator. The anti-caking agent is sprayed by atomization with a particle size of 5-10μm. The anti-caking agent and powder are uniformly mixed by airflow stirring. Qualified powder with a particle size of 100-200μm is screened out. Large particles on the sieve are sent to a grinder for crushing and then returned to the separator. Qualified powder is cooled to room temperature by a cooler and then sent to a sealed moisture-proof storage tank. The inner wall of the sealed moisture-proof storage tank is coated with polytetrafluoroethylene to prevent powder adsorption and adhesion. The flow rate of nitrogen-protected gas is 0.1-0.2m³ / h. The storage tank is equipped with a nitrogen protection device and the humidity, temperature and pressure of the dry air are monitored in real time. The dew point temperature of the refrigerated dryer and the power of the heater are adjusted by a PLC system. The monitoring frequency of the PLC system is 1 time / second. When the relative humidity of the dry air exceeds 2.5%, the power of the refrigerated dryer is automatically triggered. Step 5: The entire drying process uses a closed-loop equipment connection to prevent external moisture and impurities from entering. After drying, the powder is tested for microorganisms. Based on the type of solvent residue in D-ribose crystals, the ratio is 1:2 when the solvent residue is mainly alcohol and 1:4 when it is mainly ketone. The compound ratio of silica and maltodextrin in the anti-caking agent is adjusted. Finally, the finished D-ribose powder is tested for agglomeration. In the compound system of the anti-caking agent, the particle size of food-grade silica is 5-20nm and the DE value of maltodextrin is 10-20.

[0023] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A process for the dry processing of anti-caking D-ribose, characterized in that, The method comprises the following steps: Step one, the moisture-containing D-ribose crystal obtained by microbial conversion is dehydrated by centrifugal filter dryer to remove the surface free solvent, and a filter cake material is obtained; Step two, the drying air is sequentially subjected to impurity removal by a primary filter, compression by an air compressor, temperature reduction by a cooler, oil and water removal by a cyclone separator, and deep dehumidification by a cold dryer, and is then adjusted to 4.0-8.0 KPa by a regulating valve, heated to 35-50℃ by a heater, and finally filtered by two stages of a 0.3 μm pre-filter and a 0.01 μm sterile filter to obtain dry air with a relative humidity of 1.0%-2.5%; Step three, the pretreated filter cake D-ribose is fed into a drying column, the dry air is fed from the bottom of the column, the mixing ratio of the material and the air is (4:1)-(7:1), the material is fluidized and suspended with the airflow, the drying time is 1-4 seconds, rapid dehydration is realized, and an anti-caking agent is uniformly sprayed on the dried D-ribose powder at the outlet of the drying column, the spraying amount being 0.1%-0.3% of the mass of the material; Step four, the D-ribose powder containing the anti-caking agent is fed into a particle size sifter, and the qualified powder with a particle size of 100-200 μm is screened out, the qualified powder is cooled to room temperature by a cooler, and is then fed into a sealed moisture-proof storage tank for storage, a nitrogen protection device is arranged in the storage tank, and the humidity, temperature and pressure of the dry air are monitored in real time, and the dew point temperature of the cold dryer and the power of the heater are adjusted by a PLC system; Step five, the whole drying process is connected by a closed equipment to avoid the entry of external moisture and impurities, the powder after drying is subjected to microbial detection, the compounding ratio of silicon dioxide and malt dextrin in the anti-caking agent is adjusted according to the solvent residue type of the D-ribose crystal, and finally the finished product D-ribose powder is subjected to caking test.

2. A process for the dry processing of D-ribose to prevent caking according to claim 1, characterized in that, In step one, the centrifugal filter dryer rotates at a speed of 3000-5000 rpm for 10-15 minutes to loosen the structure of the filter cake and realize subsequent drying.

3. A process for the dry processing of D-ribose to prevent caking according to claim 1, characterized in that, In step two, the air is heated at a rate of 5-10℃ / min by the heater after deep dehumidification by the cold dryer.

4. The process for the dry processing of D-ribose without caking according to claim 1, characterized in that, In step three, a guide plate is arranged in the drying column to guide the airflow to form a spiral upward flow, thereby prolonging the contact time of the material and the air.

5. A process for the dry processing of D-ribose to prevent caking according to claim 1, characterized in that, In step four, the anti-caking agent is sprayed in an atomization manner, the atomization particle size is 5-10 μm, and the anti-caking agent is uniformly mixed with the powder by airflow stirring.

6. A process for the dry processing of D-ribose to prevent caking according to claim 1, characterized in that, In step four, the inner wall of the sealed moisture-proof storage tank is coated with polytetrafluoroethylene to avoid powder adsorption and adhesion, and the gas flow rate of the nitrogen protection is 0.1-0.2 m³ / h.

7. A process for the dry processing of D-ribose to prevent caking according to claim 1, characterized in that, In step four, the monitoring frequency of the PLC system is 1 time / second, and the power of the cold dryer is automatically adjusted when the relative humidity of the dry air exceeds 2.5%.

8. A process for the dry processing of D-ribose to prevent caking according to claim 1, characterized in that, In step four, the large particle materials on the screen are crushed by a grinder and then returned to the sifter.

9. A process for the dry processing of D-ribose to prevent caking according to claim 1, wherein, In step five, the particle size of the food-grade silicon dioxide in the compounding system of the anti-caking agent is 5-20 nm, and the DE value of the malt dextrin is 10-20.

10. The process for the dry processing of D-ribose without caking according to claim 1, characterized in that, In step five, the ratio of alcohol-based solvent residue is 1:2, and the ratio of ketone-based solvent residue is 1:4.

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