External medicine for removing bromhidrosis and preparation method thereof
By using a combination of specific natural ingredients and excipients, a topical medication for treating underarm odor has been prepared, solving the problems of significant side effects and insignificant efficacy of existing drugs, and achieving a solution that is effective in treating underarm odor without toxic side effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-02-04
- Publication Date
- 2026-03-10
AI Technical Summary
Existing topical medications for treating underarm odor have problems such as significant side effects, insignificant and short-lasting effects, inconvenience in use, and easy staining of clothing.
This product uses natural ingredients such as ephedra root, kudzu root, Sichuan pepper, perilla, calendula, tangerine peel, agastache, atractylodes, sophora flavescens extract, purslane extract, ginger extract, zinc oxide, and citric acid, combined with excipients IPM, Tween 20, rosemary essential oil, and Kathon, to prepare a topical medication for treating underarm odor. It achieves its deodorizing effect through antiperspirant, antibacterial, and soothing properties.
It achieves a non-toxic, gentle, fast-acting, effective, convenient, and long-lasting effect in removing underarm odor, without staining clothing.
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of topical medications for treating axillary odor, specifically relating to a topical medication for treating axillary odor and its preparation method. Background Technology
[0002] Axillary bromhidrosis, also known as bromhidrosis, refers to sweat with a distinctive odor or an unpleasant smell after decomposition. It is a common medical condition, and current treatments primarily include topical medications, local injections, and surgical excision. However, topical injections and surgical excision are invasive procedures and generally not well-received.
[0003] Topical medications come in liquid, powder, and ointment forms, each with varying effects. The purpose of topical medication is to reduce perspiration, inhibit bacteria, and mask odor. Topical medications are the least painful and most readily accepted treatment method, but they only temporarily mask odor and are not long-lasting, requiring consistent long-term use. They cannot cure the odor, and their effectiveness depends on the medication's efficacy. Some medications may cause adverse reactions such as rough skin, pigmentation, and peeling, and some patients with sensitive skin may experience skin allergies.
[0004] Existing topical medications include traditional Chinese medicine and Western medicine. Traditional Chinese medicine treatment for armpit odor primarily follows the principles of dispelling foul odors with aromatic herbs, dispelling wind and dampness, stopping sweating and eliminating odor, and regulating qi and blood. Commonly used herbs include alum, realgar, litharge, talc, patchouli, angelica dahurica, chuanxiong rhizome, and angelica sinensis. These herbs are applied to the affected area to stop sweating or mask odor with fragrance. A commonly used compound Chinese medicine formula is Zhongjing Armpit Odor Powder, a classic formula for treating armpit odor, composed of red powder, calcined alum, cloves, gypsum, and dragon bone. It can inhibit sweat secretion and effectively reduce armpit odor; however, the red powder in the formula is highly toxic and has many side effects, making it unsuitable for long-term use. Furthermore, traditional powders, due to their large particle size, are prone to clumping and causing discomfort during application.
[0005] Western medicine treatments for bromhidrosis primarily involve applying topical antiperspirants and antibacterial medications to the affected area to eliminate odor. These typically use astringents such as copper sulfate, aluminum chloride, zinc sulfate, or silver nitrate solutions to close pores, and then mask or remove the odor with deodorants. However, this method disrupts the body's normal sweat excretion function, easily leading to side effects such as itching, redness, and ulceration. Commercially available urotropine solutions are particularly potent, often causing dryness and cracking at the application site, and in some cases, skin irritation such as burning sensations, or allergic reactions such as rashes and itching. Summary of the Invention
[0006] To address the problems in the existing technology, this invention provides a topical drug for treating underarm odor and its preparation method, achieving the goals of being mild, non-irritating, non-toxic, fast-acting, highly effective, easy to use, long-lasting, and non-staining on clothing.
[0007] The technical problem solved by this invention is achieved by the following technical solution:
[0008] The purpose of this invention is to provide a topical medicine for treating underarm odor, comprising active ingredients including ephedra root, kudzu root, Sichuan pepper, perilla, calendula, tangerine peel, agastache, atractylodes, sophora flavescens extract, purslane extract, ginger extract, zinc oxide, and citric acid.
[0009] Furthermore, by weight, it includes 1-4 parts of Ephedra root, 2-5 parts of Pueraria root, 3-8 parts of Sichuan pepper, 1-6 parts of Perilla, 1-5 parts of Calendula, 2-4 parts of Tangerine peel, 3-6 parts of Eupatorium fortunei, 2-5 parts of Atractylodes lancea, 0.2-2 parts of Sophora flavescens extract, 2-5 parts of Portulaca oleracea extract, 0.1-1 parts of ginger extract, 1-3 parts of zinc oxide, and 0.1-1 parts of citric acid.
[0010] Furthermore, it also includes excipients, such as IPM, Tween 20, rosemary essential oil, and Kathon.
[0011] Furthermore, by weight, IPM 2-6 parts, Tween 20 1-3 parts, rosemary essential oil 0.05-0.5 parts, and Kathon 0.01-0.1 parts.
[0012] Furthermore, by weight, the ingredients include 2 parts ephedra root, 3 parts kudzu root, 6 parts Sichuan pepper, 4 parts perilla, 3 parts calendula, 3 parts dried tangerine peel, 4 parts agastache, 3 parts atractylodes, 1 part sophora flavescens extract, 3 parts purslane extract, 0.5 parts ginger extract, 2 parts zinc oxide, 0.3 parts citric acid, 4 parts IPM, 2 parts Tween 20, 0.3 parts rosemary essential oil, and 0.1 parts Kathon.
[0013] The present invention also aims to provide a method for preparing a topical drug for treating underarm odor, comprising the following steps:
[0014] S1: First, remove impurities from Ephedra root, Kudzu root, Sichuan pepper, Perilla, Calendula, Tangerine peel, Eupatorium, and Atractylodes lancea, then soak them. Next, cut and dry the herbs, then soak and decoct them, cool and filter to obtain the Chinese herbal extract.
[0015] S2: Add the Sophora flavescens extract, Portulaca oleracea extract, ginger extract and citric acid to S1 and stir until completely dissolved; to obtain a mixed extract.
[0016] S3: Mix zinc oxide and rosemary essential oil into IPM and stir evenly. Then add Tween 20 solution and sonicate to obtain a dispersion.
[0017] S4: Mix S2 and S3, homogenize and filter to obtain the drug for removing underarm odor.
[0018] Further, in S1, first remove impurities from Ephedra root, Kudzu root, Sichuan pepper, Perilla, Calendula, Tangerine peel, Eupatorium, and Atractylodes, then soak them in a washing and moistening tank with water 3-5 cm above the herbs. After soaking for 4 hours, let them sit for 3-5 hours. Cut the herbs into small pieces or slices and dry them in an oven at 50 degrees Celsius with a conveyor belt speed of 0.3-0.5 meters per minute. After drying, cool to room temperature and soak in 15-20 times the amount of purified water for 0.5-1 hour. Then heat and decoct until boiling, maintain the temperature for 1 hour, and cool. Filter through a 100-120 mesh screen to obtain the herbal extract.
[0019] Further, in step S4, the mixed extract of S2 is added to an emulsifier and the wall-scraping stirring speed is set to 1000-1200 rpm. Then, the dispersion of S3 is slowly injected into the mixed extract, and the homogenizer is turned on at a frequency of 1500-2500 rpm. After homogenizing for 5-15 minutes, Kathon is added, and stirring is continued for 30-60 minutes. The mixture is then filtered through a 150-250 mesh screen to obtain the axillary odor removal drug.
[0020] Citric acid is a commonly used pH adjuster in cosmetics, but in this invention it is used as an astringent; Sophora flavescens extract, ginger extract and purslane extract have antibacterial and anti-inflammatory effects; rosemary essential oil is used for fragrance;
[0021] A pH that is too low can increase skin irritation. In this invention, zinc oxide is used to regulate the pH; Tween 20 is used as a solubilizer, stabilizer, and suspending agent; Kathon is used as a preservative; and isopropyl myristate (IPM) is used to aid penetration and fix the fragrance.
[0022] Ephedra root stops sweating, Sichuan pepper and agastache deodorize and inhibit bacteria, calendula and dried tangerine peel have antibacterial and soothing properties, and kudzu root and atractylodes have anti-inflammatory and antibacterial effects. All the herbal extracts work together to achieve the effects of stopping sweating, inhibiting bacteria, and soothing.
[0023] The present invention ensures the effectiveness of removing underarm odor through the interaction of these active ingredients. At the same time, it uses natural ingredients such as ephedra root, kudzu root, Sichuan pepper, perilla, calendula, tangerine peel, agastache, atractylodes, sophora flavescens extract, purslane extract, and ginger extract, making the product non-toxic and avoiding the use of chemically synthesized bactericides that are toxic to the human body.
[0024] Among the excipients, Tween 20 and IPM solubilize and enhance drug penetration, thereby improving product stability and efficacy. Rosemary essential oil serves to impart fragrance and suppress odor.
[0025] Compared with the prior art, the beneficial technical effects of the present invention are as follows:
[0026] This invention provides a topical medication for treating underarm odor that is highly effective, has no toxic side effects, and exhibits stable performance. It possesses antibacterial, deodorizing, antiperspirant, moisturizing, and fragrance-enhancing properties, making it a multifunctional topical medication for treating underarm odor. The product is gentle, non-irritating, has no toxic side effects, is fast-acting, has significant therapeutic effects, is easy to use, has a long-lasting effect, and does not stain clothing.
[0027] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention, it can be implemented according to the contents of the specification. Furthermore, in order to make the above contents, objectives, features and advantages of the present invention more obvious and understandable, specific embodiments of the present invention are described below. Detailed Implementation
[0028] The technical solution of the present invention will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanatory of the present invention and should not be construed as limiting the scope of protection of the present invention. All technologies implemented based on the above content of the present invention are covered within the scope of protection intended by the present invention.
[0029] In addition, unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be obtained by purchasing them from the market or prepared by existing methods.
[0030] The active ingredients of this invention's anti-axillary odor medicine are extracts of ephedra root, kudzu root, Sichuan pepper, perilla, calendula, tangerine peel, agastache, atractylodes, sophora flavescens, purslane, ginger, zinc oxide, and citric acid. Excipients include IPM, Tween 20, rosemary essential oil, and Kathon. All components are commercially available or prepared using existing technologies.
[0031] Weigh each component according to the following mass proportions: 1-4 parts of Ephedra root, 2-5 parts of Pueraria root, 3-8 parts of Sichuan pepper, 1-6 parts of Perilla, 1-5 parts of Calendula, 2-4 parts of Tangerine peel, 3-6 parts of Eupatorium fortunei, 2-5 parts of Atractylodes lancea, 0.2-2 parts of Sophora flavescens extract, 2-5 parts of Portulaca oleracea extract, 0.1-1 parts of Zingiber officinale extract, 1-3 parts of Zinc oxide, 0.1-1 parts of Citric acid, 2-6 parts of IPM, 1-3 parts of Tween 20, 0.05-0.5 parts of Rosemary essential oil, and 0.01-0.1 parts of Kathon.
[0032] This invention provides a medication for treating underarm odor, which can be packaged in either a liniment (topical application) or a spray bottle (aerosol spray). When using the liniment bottle, apply a few drops of the medication to a piece of medical absorbent cotton and gently apply it to the armpits. Odor is eliminated within minutes, especially after showering. It can be applied once every 6-10 days. When using the spray bottle, simply spray the medication directly onto the affected area.
[0033] Example 1
[0034] 1. First, remove impurities from ephedra root, kudzu root, Sichuan pepper, perilla, calendula, dried tangerine peel, agastache, and atractylodes. Soak them in a washing and moistening tank with water 3 cm above the herbs for 4 hours. Then, let them sit for 3 hours to moisten. Cut the herbs into small, evenly sized pieces or slices. Dry them in an oven at 50 degrees Celsius with a conveyor belt speed of 0.3 m / min. After drying, let them cool to room temperature and weigh them. Do not slice herbs smaller than 0.5 cm. Soak them in 20 times their volume of purified water for 0.5 hours, then heat and decoct until boiling. Maintain the boiling state for 1 hour, then cool and filter through a 100-mesh sieve for later use.
[0035] 2. Weigh out the extracts from step 1 after filtration: 1 part ephedra root, 2 parts kudzu root, 3 parts Sichuan pepper, 1 part perilla, 1 part calendula, 2 parts dried tangerine peel, 3 parts agastache, and 2 parts atractylodes. Set aside.
[0036] 3. Add 0.2 parts of Sophora flavescens extract, 2 parts of Portulaca oleracea extract, 0.1 parts of ginger extract, and 0.1 parts of citric acid to the mixture from step 2 above and stir until completely dissolved. The stirring frequency is set to 50 Hz. During this process, continuously add materials and observe the dissolution of the extracts. If not completely dissolved, increase the stirring speed to 60 Hz or extend the stirring time by 30 minutes. Obtain the mixed extract.
[0037] 4. Pass zinc oxide through a 120-mesh filter to improve dispersibility. Mix 1 part Tween 20 with 5 parts purified water. Add 1 part zinc oxide powder and 0.05 parts rosemary essential oil to 2 parts IPM for pre-dispersion. Then add the Tween 20 solution and perform preliminary mixing with magnetic stirring. Then place it in an ultrasonic cleaner or probe ultrasonic instrument for 10 minutes to obtain a uniform and stable dispersion.
[0038] 5. Add the mixed extract from step 3 into an emulsifier and turn on the wall scraping and stirring speed to 1000 rpm. Then slowly inject the dispersion from step 4 into the mixed extract, and at the same time turn on the homogenizer and set the frequency to 1500 rpm. After homogenizing for 5 minutes, add 0.02 parts of Kathon and continue stirring for 30 minutes. Pass the mixture through a 150-mesh filter to obtain the anti-axillary odor topical medication.
[0039] 6. Once the product passes the inspection, it can be filled.
[0040] Tests showed that too little essential oil and extract were added, and the ultrasonic treatment time was too short, making it difficult to achieve the best results. The procedure was repeated.
[0041] Example 2
[0042] 1. First, remove impurities from ephedra root, kudzu root, Sichuan pepper, perilla, calendula, dried tangerine peel, agastache, and atractylodes. Soak them in a washing and moistening tank with water 5 cm above the herbs for 4 hours, then let them sit for 5 hours. Cut the herbs into small, evenly sized pieces or slices. Dry them in an oven at 50 degrees Celsius with a conveyor belt speed of 0.5 m / min. After drying, let them cool to room temperature and weigh them. Do not slice herbs smaller than 0.5 cm. Soak them in 15 times their volume of purified water for 1 hour, then heat and decoct until boiling. Maintain the boiling state for 1 hour, then cool and filter through a 110-mesh sieve for later use.
[0043] 2. Weigh out the following Chinese herbal extracts after filtration in step 1: 4 parts ephedra root, 5 parts kudzu root, 8 parts Sichuan pepper, 6 parts perilla, 5 parts calendula, 4 parts dried tangerine peel, 6 parts agastache, and 5 parts atractylodes. Set aside.
[0044] 3. Add 2 parts of Sophora flavescens extract, 5 parts of Portulaca oleracea extract, 1 part of ginger extract, and 1 part of citric acid to the mixture from step 2 above and stir until completely dissolved. Set the stirring frequency to 50 Hz. Continuously add materials and observe the dissolution of the extracts. If not completely dissolved, increase the stirring speed to 60 Hz or extend the stirring time by 40 minutes. Obtain the mixed extract.
[0045] 4. Pass zinc oxide through a 120-mesh filter to improve dispersibility. Mix 3 parts Tween 20 with 15 parts purified water. Add 3 parts zinc oxide powder and 0.5 parts rosemary essential oil to 6 parts IPM for pre-dispersion. Then add the Tween 20 solution and perform preliminary mixing with magnetic stirring. Then place it in an ultrasonic cleaner or probe ultrasonic instrument for 30 minutes to obtain a uniform and stable dispersion.
[0046] 5. Add the mixed extract into the emulsifier and turn on the wall scraping and stirring speed to 1100 rpm. Then slowly inject the dispersion into the mixed extract and turn on the homogenizer at a frequency of 2500 rpm. After homogenizing for 15 minutes, add 0.1 parts of Kathon and continue stirring for 45 minutes. Then filter through a 200-mesh filter to obtain the axillary odor removal drug.
[0047] 6. Once the product passes the inspection, it can be filled.
[0048] Testing revealed that the high zinc oxide content made dissolution relatively difficult, and the pH was low. However, the overall properties were good, and it can be considered a relatively good formulation. To further refine the formulation, another example was implemented.
[0049] Example 3
[0050] 1. First, remove impurities from ephedra root, kudzu root, Sichuan pepper, perilla, calendula, dried tangerine peel, agastache, and atractylodes. Soak them in a washing and moistening tank with water 4 cm above the herbs for 4 hours. Then, let them sit for another 4 hours to moisten them. Cut the herbs into small, evenly sized pieces or slices. Dry them in an oven at 50 degrees Celsius with a conveyor belt speed of 0.4 m / min. After drying, let them cool to room temperature and weigh them. Do not slice herbs smaller than 0.5 cm. Soak them in 18 times their volume of purified water for 1 hour, then heat and decoct until boiling. Maintain the boiling state for 1 hour, then cool and filter through a 120-mesh sieve for later use.
[0051] 2. Weigh out the extracts from step 1 after filtration: 2 parts of Ephedra root, 3 parts of Kudzu root, 6 parts of Sichuan pepper, 4 parts of Perilla frutescens, 3 parts of Calendula officinalis, 3 parts of dried tangerine peel, 4 parts of Eupatorium fortunei, and 3 parts of Atractylodes lancea. Set aside.
[0052] 3. Add 1 part of Sophora flavescens extract, 3 parts of Portulaca oleracea extract, 0.5 parts of ginger extract, and 0.3 parts of citric acid to the mixture from step 2 above and stir until completely dissolved. The stirring frequency is set to 50 Hz. During this process, continuously add materials and observe the dissolution of the extracts. If not completely dissolved, increase the stirring speed to 60 Hz or extend the stirring time by 50 minutes. Obtain the mixed extract.
[0053] 4. Pass zinc oxide through a 120-mesh filter to improve dispersibility. Mix 2 parts Tween 20 with 10 parts purified water. Add 2 parts zinc oxide powder and 0.3 parts rosemary essential oil to 4 parts IPM for pre-dispersion. Then add the Tween 20 solution and perform preliminary mixing with magnetic stirring. Then place it in an ultrasonic cleaner or probe ultrasonic instrument for 60 minutes to obtain a uniform and stable dispersion.
[0054] 5. Add the mixed extract into the emulsifier and turn on the wall-scraping stirring speed to 1200 rpm. Then slowly inject the dispersion into the mixed extract and turn on the homogenizer at a frequency of 2000 rpm. After homogenizing for 10 minutes, add 0.1 parts of Kathon and continue stirring for 60 minutes. Then filter through a 250-mesh filter to obtain the axillary odor removal drug.
[0055] 6. Once the product passes the inspection, it can be filled.
[0056] Testing revealed that this embodiment represents the optimal formulation in terms of both properties and efficacy.
[0057] Comparative Example 1
[0058] Take 100g of urotropine, 700ml of 95% ethanol, 200ml of propylene glycol, 5g of sodium benzoate, and 0.1ml of lemon flavoring, and add water to 1000ml. The preparation method is as follows: Dissolve the urotropine in the propylene glycol and ethanol solution by stirring until homogeneous. Then add distilled water to adjust the pH to 8. Add sodium benzoate and lemon flavoring, stir until homogeneous, filter, inspect the intermediates, fill into spray bottles, seal, package, and after passing inspection, it is the finished product. Urotropine spray: can be directly sprayed onto the affected area for accurate dosage and improved antibacterial activity.
[0059] Comparative Example 2
[0060] Take 4.0 kg of coral ginger essential oil, 1.0 kg of wild chrysanthemum supercritical CO2 extract, 0.4 kg of clove supercritical CO2 extract, 1.5 kg of p-chloro-m-xylenol, 3.0 kg of AES (sodium fatty alcohol polyoxyethylene ether sulfate), and 0.5 kg of polyoxyethylene (40) hydrogenated castor oil and dissolve them in a mixed solution of 42.0 kg of ethanol and 5.0 kg of propylene glycol at room temperature. Dissolve 2.0 kg of zinc phenol p-sulfonate in 40.5 kg of deionized water. Then place the aqueous solution phase into the alcohol solution phase, add 0.1 kg of fragrance, homogenize for 15 min, and filter to obtain this coating agent.
[0061] Experimental Example 1
[0062] 1. Selection of experimental subjects
[0063] Two hundred and fifty patients who met the diagnostic criteria for axillary osmidrosis were selected and randomly divided into five groups of 50 each.
[0064] Inclusion criteria: 1. Patients diagnosed with axillary osmidrosis who have not undergone surgical treatment; 2. Age 18–50 years;
[0065] Exclusion criteria: ① Skin infections, eczema, or fungal infections in the armpits; ② Pregnant or breastfeeding women, or women during menstruation; ③ Allergic constitution; ④ Liver or kidney diseases, or abnormal liver function.
[0066] 2. Experimental Grouping
[0067] Example 1: Group 1 consisted of 28 males and 22 females, aged 19–46 years, with a mean age of 29.15 ± 3.52 years. Among them, 7 cases were mild, 7 cases were moderate, and 36 cases were severe.
[0068] Example 2: Group 2 included 31 males and 19 females, aged 18–49 years, with a mean age of 28.32 ± 2.29 years. Among them, 5 cases were mild, 6 cases were moderate, and 39 cases were severe.
[0069] Example 3: Group 30 included 30 males and 20 females, aged 19–50 years, with a mean age of 30.12 ± 3.43 years. Among them, 6 cases were mild, 4 cases were moderate, and 40 cases were severe.
[0070] In the control group, there were 31 males and 19 females, aged (18-45) years, with a mean age of (28.47±2.89) years; among them, there were 8 mild cases, 5 moderate cases, and 37 severe cases.
[0071] The comparative group consisted of 29 males and 21 females, aged 19–48 years, with a mean age of 28.97 ± 3.18 years. Among them, there were 3 mild cases, 9 moderate cases, and 38 severe cases.
[0072] Severity rating method for armpit odor:
[0073] Patient self-assessment: 0 points: no odor; 1 point: occasionally smells odor when nose is near armpit after strenuous activity, does not affect social activities; 2 points: smells odor when nose is not near armpit, feels it affects social activities; 3 points: smells odor at all times, feels it seriously affects social activities.
[0074] Doctor's assessment: assessed by 2 regular doctors: 0 points for no odor; 1 point for occasional odor on gauze after wiping the armpit; 2 points for odor that can be smelled when the armpit is exposed during the examination; 3 points for odor that can be smelled when the armpit is not exposed and the patient is nearby or at a distance.
[0075] The severity of axillary osmidrosis was determined by combining the total scores from the patient's and two doctors' assessments: normal: 0 points; mild: 1-3 points; moderate: 4-6 points; severe: 7-9 points.
[0076] There were no statistically significant differences in gender, age, and disease duration among the five groups of patients (P>0.05).
[0077] 3. Treatment methods
[0078] a. Clean both sides thoroughly before the test, and do not use similar products within 2 weeks before the test;
[0079] b. Subjects cleaned their armpits with saline solution. One hour later, baseline values were assessed in both armpits. After assessment, Comparative Example 1, Comparative Example 2, and Examples 1-3 were used until absorption. Five minutes after application, both armpits were assessed and photographed using a dermoscope. After the test, subjects were given instructions on use and provided with the product and a usage diary.
[0080] c. Ten days later, on the 11th day, clean the armpits with saline solution. One hour later, apply the product to both sides until absorbed. Five minutes after application, assess one armpit and take a dermatological photograph.
[0081] d. Adjust the dosage and administration method according to the patient's constitution and severity. One month constitutes one course of treatment, and three courses of treatment are required.
[0082] 4. Assess the effectiveness of treatment
[0083] Significant effect: After treatment, no odor was detected within 20cm of the armpit even when sweating, and the amount of sweat under the armpit was significantly reduced;
[0084] Effective: After treatment, the odor is not obvious within 20cm of the armpit when sweating, and the amount of sweat under the armpit is reduced to a certain extent;
[0085] Ineffective: After treatment, the odor was noticeable within 20cm of the armpit even when sweating, and the amount of sweat under the armpit did not change significantly.
[0086] Overall effectiveness rate = (Number of people with significant effects + Number of people with effective results) ÷ Total number of people × 100%. The experimental results are shown in Table 1 below.
[0087] Table 1
[0088] Note: Irritation reactions include at least one of the following: skin allergy, itching, redness, swelling, and ulceration.
[0089] The above experimental examples show that Comparative Examples 1 and 2 are slightly closer to the efficacy of Examples 1 and 2 of the present invention, but still not as good as Examples 1 and 2 of the present invention. In particular, after 1 to 2 months of use, the efficacy of Examples 1 and 2 of the present invention reaches about 92%, which is faster. After 3 months of use, the efficacy is close to 100%. Moreover, the efficacy of Comparative Examples 1, 2, Examples 1 and 2 is not as good as the technical solution of Example 3 of the present invention. The solution of Example 3 of the present invention has the best effect. At the same time, the number of people who experienced irritation in Examples 1-3 of the present invention is significantly lower than that in Comparative Examples 1 and 2. That is to say, the anti-axillary odor liniment of the present invention can achieve an almost non-irritating effect.
[0090] The sequence numbers of the above embodiments of the present invention are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments.
[0091] The embodiments of the present invention have been described above, but the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims, and these forms are all within the protection scope of the present invention.
Claims
1. An external medicine for removing underarm odor, characterized by comprising: By mass fraction, it comprises active ingredients: Ephedra 1-4 parts, Pueraria 2-5 parts, Zanthoxylum 3-8 parts, Perilla 1-6 parts, Calendula 1-5 parts, Citrus 2-4 parts, Pterocephalus 3-6 parts, Atractylodes 2-5 parts, Sophora extract 0.2-2 parts, Gynostemma extract 2-5 parts, Ginger extract 0.1-1 part, zinc oxide 1-3 parts, citric acid 0.1-1 part; and auxiliary materials: IPM 2-6 parts, Tween 20 1-3 parts, rosemary essential oil 0.05-0.5 parts and casson 0.01-0.1 part. 2. The topical medication for treating underarm odor as described in claim 1, characterized in that: By mass fraction, it comprises Ephedra 2 parts, Pueraria 3 parts, Zanthoxylum 6 parts, Perilla 4 parts, Calendula 3 parts, Citrus 3 parts, Pterocephalus 4 parts, Atractylodes 3 parts, Sophora extract 1 part, Gynostemma extract 3 parts, Ginger extract 0.5 part, zinc oxide 2 parts, citric acid 0.3 part, IPM 4 parts, Tween 20 2 parts, rosemary essential oil 0.3 part and casson 0.1 part.
3. The preparation method of the external medicine for removing axillary odor according to claim 1 or 2, characterized in that: It comprises the following steps: S1: first, soak the Ephedra, Pueraria, Zanthoxylum, Perilla, Calendula, Citrus, Pterocephalus and Atractylodes after removing impurities, then cut and dry the medicinal materials, and then soak and decoct, cool and filter to obtain a traditional Chinese medicine extract; S2: then add Sophora extract, Gynostemma extract, Ginger extract and citric acid to S1 and stir until completely dissolved to obtain a mixed extract; S3: mix zinc oxide and rosemary essential oil into IPM, disperse and stir uniformly, then add Tween 20 solution and ultrasonic treatment to obtain a dispersion; S4: mix S2 and S3, homogenize and filter to obtain an axillary odor-removing medicine.
4. The preparation method of the external medicine for removing axillary odor according to claim 3, characterized in that: In S1, first remove the impurities of Ephedra, Pueraria, Zanthoxylum, Perilla, Calendula, Citrus, Pterocephalus and Atractylodes, soak them in a soaking pool, the water amount is 3-5 centimeters more than the medicinal materials, soak for 4 hours, then dampen for 3-5 hours, cut the medicinal materials into small pieces or small pieces, dry them in an oven, set the oven temperature to 50 degrees Celsius, and the conveying belt speed to 0.3-0.5 meters per minute, and then cool to room temperature after drying; Soak in 15-20 times of purified water for 0.5-1 hour, then heat and decoct, maintain the temperature for 1 hour after boiling, cool, and filter through a 100-120 mesh screen to obtain a traditional Chinese medicine extract.
5. The preparation method of the topical drug for treating axillary odor as described in claim 3, characterized in that: In S4, add the mixed extract of S2 into an emulsifier, set the scraping wall stirring speed to 1000-1200 revolutions per minute, then inject the dispersion of S3 into the mixed extract, start the homogenizer at a frequency of 1500-2500 revolutions per minute, homogenize for 5-15 minutes, then add casson, continue stirring for 30-60 minutes, and then filter through a 150-250 mesh screen to obtain an axillary odor-removing medicine.