Sulfur composition as well as preparation method and application thereof

Abstract

The invention discloses a sulfur composition as well as a preparation method and application thereof, and relates to the technical field of skin products. The invention provides a sulfur composition. The sulfur composition is prepared from components in parts by weight as follows: 0.5-5 parts of a quaternary ammonium salt type cationic emulsifier, 5-30 parts of a nonionic emulsifier, 0.05-2 parts of sulfur and 60-95 parts of water, the light transmittance of the sulfur composition is greater than or equal to 85%. According to the compound system of the quaternary ammonium salt type cationic emulsifier and the specific nonionic emulsifier, breakthrough transformation of sulfur from a granular state to a molecular state is achieved, stable dispersion is achieved, and long-acting existence of molecular state sulfur is guaranteed.

Description

Technical Field

[0001] This application relates to the field of cleaning products technology, and in particular to a sulfur composition, its preparation method and application. Background Technology

[0002] Sulfur, a natural mineral with a long history of application, has multiple uses in antibacterial, anti-inflammatory, oil-controlling, and keratolytic applications. Modern pharmacological studies have confirmed that sulfur can effectively block microbial proliferation by inhibiting the metabolic enzyme activity of bacteria and fungi, thereby playing a therapeutic role in common skin diseases caused by bacterial or fungal infections, such as eczema, acne, and scabies. Simultaneously, sulfur can stimulate the release of specific neurotransmitters at the nerve endings in the skin, achieving significant antipruritic and analgesic effects by regulating local nerve signal transmission. However, due to the unique molecular structure of sulfur, it exists as a stable solid at room temperature and pressure with extremely low solubility, making it difficult to act directly on the skin in molecular form. This characteristic limits its application; currently, sulfur-related products on the market are all dispersed in a granular form within a matrix, with typical products including sulfur ointment, sulfur soap, sulfur shower gel, and sulfur shampoo.

[0003] Although the above-mentioned granular sulfur products have been applied on a large scale, they have revealed many insurmountable technical defects in actual use, which seriously affect their application effect and user experience. Specifically, they are reflected in the following aspects: (1) The effective utilization rate of granular sulfur products is low and the amount added is too high: The contact between granular sulfur and the skin is limited to the surface of the particles. The effective ingredients inside are difficult to be absorbed and utilized by the skin. In order to achieve the expected therapeutic effect, the amount of sulfur added in the product usually needs to be controlled within a high range, which not only increases the cost of raw materials, but also increases the risk of skin irritation. (2) The problem of characteristic odor residue is prominent: The presence of a large number of sulfur particles makes it difficult for the product to leave a distinct sulfur odor on the skin surface after use. This odor lasts for a long time, which causes great trouble to users in social situations and significantly reduces the acceptance of the product. (3) Poor stability and difficult cost control: Sulfur particles are prone to aggregation and sedimentation in the product matrix due to Brownian motion, gravity and other factors. Although surface modification can be used to prepare colloidal sulfur to improve dispersibility, this process requires additional processing technology for coating, which significantly increases production costs. On the other hand, the surface modification layer will further hinder the direct contact between sulfur and skin, resulting in a further reduction in its effective utilization rate.

[0004] Therefore, in view of the core technical defects of existing granular sulfur products, such as low effective utilization rate, large addition amount, obvious odor residue and poor stability, there is an urgent need in this field to develop a new form of sulfur application to overcome the technical bottleneck caused by the low solubility of sulfur. Summary of the Invention

[0005] Based on this, the purpose of this application is to overcome the shortcomings of the prior art and provide a sulfur composition, its preparation method and application.

[0006] To achieve the above objectives, a first aspect of this application provides a sulfur composition comprising the following components in parts by weight: 0.5-5 parts of a quaternary ammonium salt cationic emulsifier, 5-30 parts of a nonionic emulsifier, 0.05-2 parts of sulfur, and 60-95 parts of water; the sulfur composition having a light transmittance ≥85%; the quaternary ammonium salt cationic emulsifier comprising at least one of palmitamide propyltrimethylammonium chloride, hymexazolium chloride, and undecylaminopropyltrimethylammonium methyl sulfate; the nonionic emulsifier comprising at least one of PEG-7 glyceryl cocoate, di(PPG-2 myristyl alcohol polyether-10) adipate, di(PPG-3 myristyl ether) adipate, polyglycerol-4 lauryl ester, PEG-6 caprylic / capric glycerides, and lauryl alcohol polyether-4.

[0007] This application, after extensive screening and verification, identified a compound system of quaternary ammonium salt cationic emulsifier + specific nonionic emulsifier. Through the synergistic effect of these specific surfactants, this application achieves a breakthrough transformation of sulfur from a particulate state to a molecular state, dissolving the sulfur and uniformly dispersing it in molecular form between the aqueous and oil phases. This molecular-level dispersion significantly improves the system's light transmittance, resulting in a stable sulfur composition with high light transmittance. This compound system of quaternary ammonium salt cationic emulsifier + specific nonionic emulsifier improves the effective utilization rate of sulfur, achieves stable sulfur dispersion, and ensures the long-term existence of molecular sulfur. Molecular sulfur refers to sulfur uniformly dispersed between the aqueous and oil phases in a non-particulate form.

[0008] As an embodiment of this application, the transmittance of the sulfur composition is a range of one or any two of 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, and 96%.

[0009] As an embodiment of this application, the sulfur composition comprises the following components in parts by weight: 1-2 parts of quaternary ammonium salt cationic emulsifier, 10-25 parts of nonionic emulsifier, 0.05-2 parts of sulfur, and 60-95 parts of water.

[0010] In some embodiments, the quaternary ammonium salt cationic emulsifier is in the range of 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts by weight, or any two of these values; the nonionic emulsifier is in the range of 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts by weight, or any two of these values; the sulfur is in the range of 0.05 parts, 0.1 parts, 0.2 parts, 0.8 parts, 1 part, 1.5 parts, 2 parts by weight, or any two of these values; and the water is in the range of 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts by weight, or any two of these values.

[0011] As an embodiment of this application, the weight ratio of the quaternary ammonium salt cationic emulsifier to the nonionic emulsifier is 1:(10-15). In some embodiments, the weight ratio of the quaternary ammonium salt cationic emulsifier to the nonionic emulsifier is one or any two of the following: 1:10, 1:11, 1:12, 1:13, 1:14, 1:15.

[0012] During actual experiments, the inventors of this application discovered that when the sulfur composition is within the above-mentioned range, the selection of the specific weight parts can more accurately realize the transformation of sulfur from particulate to molecular state. Under the selection of specific weight parts, a more stable dispersion environment can be provided, ensuring the long-term existence of molecular sulfur, thereby improving sulfur utilization.

[0013] As an embodiment of this application, the quaternary ammonium salt cationic emulsifier is a compound of palmitamidopropyltrimethylammonium chloride and hymediamine chloride; the weight ratio of palmitamidopropyltrimethylammonium chloride to hymediamine chloride is (2-4):1. In some embodiments, the weight ratio of palmitamidopropyltrimethylammonium chloride to hymediamine chloride is one or any two of the following: 2:1, 2.5:1, 3:1, 3.5:1, 4:1.

[0014] The inventors of this application discovered during actual experiments that palmitamidopropyltrimethylammonium chloride contains amide bonds, exhibits excellent biocompatibility, and its long-chain palmityl group can form an auxiliary hydrophobic effect with sulfur, resulting in milder cationic activity. Hymetrimonium chloride exhibits strong cationic activity and a high positive charge density of its quaternary ammonium groups. When the aforementioned specific selection is made of the quaternary ammonium salt-type cationic emulsifier, palmitamidopropyltrimethylammonium chloride, as the main component, ensures the mildness of the system and avoids skin irritation. Simultaneously, its long-chain structure assists in the dispersion of sulfur particles, while hymetrimonium chloride acts as a synergist to supplement cationic activity. When the quaternary ammonium salt-type cationic emulsifier is a compound of palmitamidopropyltrimethylammonium chloride and hymetrimonium chloride, the transformation of sulfur from particulate to molecular state can be achieved more precisely.

[0015] As an embodiment of this application, the nonionic emulsifier includes a first nonionic emulsifier and a second nonionic emulsifier; the first nonionic emulsifier is PEG-7 glyceryl cocoate, and the second nonionic emulsifier is bis(PPG-2 myristyl alcohol polyether-10) adipate or bis(PPG-3 myristyl ether) adipate; the weight ratio of the first nonionic emulsifier and the second nonionic emulsifier is (1-2):1. In some embodiments, the weight ratio of the first nonionic emulsifier and the second nonionic emulsifier is one of or any two of the following: 1:1, 1.5:1, 1.8:1, and 2:1.

[0016] The inventors of this application discovered during actual experiments that the combination of PEG-7 glyceryl cocoate with specific adipate esters further optimizes the system. The first nonionic emulsifier has an HLB value suitable for the aqueous system, and its hydrophilic end exhibits good compatibility with the aqueous phase. The second nonionic emulsifier contains flexible PPG chains and dual hydrophobic ends, enhancing its hydrophobic encapsulation ability. The synergistic effect of the first and second nonionic emulsifiers provides, on the one hand, sufficient hydrophilic sites to ensure micelle dispersion and prevent system stratification; on the other hand, it improves hydrophobic carrying capacity and stability, preventing the precipitation of sulfur molecules.

[0017] A second aspect of this application provides a method for preparing the sulfur composition, comprising the following steps: S1. Weigh each component according to the above-mentioned weight proportions; S2. Mix the quaternary ammonium salt cationic emulsifier, nonionic emulsifier and water evenly to obtain a mixed solution. Add sulfur to the mixed solution and heat to 80-105℃. After stirring evenly, cool to 25-30℃ to obtain the sulfur composition.

[0018] As an embodiment of this application, the heating temperature is a range of one or any two of 80°C, 82°C, 85°C, 90°C, 95°C, 100°C, and 105°C.

[0019] This application prepares a sulfur composition in a molecular state at a specific temperature of 80-105℃. At the above temperature, the transformation of sulfur from particulate to molecular state can be achieved more precisely.

[0020] In a third aspect, this application provides the use of the sulfur composition described herein in the preparation of cleaning products.

[0021] In a fourth aspect, this application provides a cleaning product comprising the sulfur composition described above.

[0022] As an implementation of this application, the cleaning products include at least one of skin cleaning and care products, fabric cleaning and care products, and animal cleaning and care products; specifically, the skin cleaning and care products include one of shampoo, soap, and shower gel, the fabric cleaning and care products include fabric washing and softening products, and the animal cleaning and care products include animal shampoo, conditioner, animal medicated bath, and other products.

[0023] As an embodiment of this application, the cleaning product comprises the following components by weight percentage: 0.05-2% of the sulfur composition, 1-40% of the matrix, and the balance being water.

[0024] In some embodiments, the sulfur composition in the cleaning product is a mass percentage of one or any two of the following values: 0.05%, 0.06%, 0.07%, 0.08%, 0.1%, 0.12%, 0.15%, 0.18%, 0.2%, 0.3%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8%, 1.0%, 1.6%, 1.8%, 1.9%, and 2.0%.

[0025] As an embodiment of this application, when the skin product is a skin cleansing and care product, the base includes at least one of thickener, moisturizer, emulsifier, preservative, fragrance, pH adjuster, conditioning agent, solubilizer, pearlescent agent, and surfactant.

[0026] For example, the thickener includes at least one of xanthan gum, ammonium acryloyldimethyl taurate / VP copolymer, and sclerotium gum.

[0027] The moisturizer includes at least one of glycerin, allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, beta-glucan, trehalose, caprylyl glycol, dipropylene glycol, hyaluronic acid, sodium hyaluronate, and 1,2-butanediol.

[0028] The emulsifier includes at least one of the following: coconut oil alcohol-caprylate / capric acid ester, polydimethylsiloxane, caprylate-capric acid triglyceride, C14-22 alcohol, C12-20 alkyl glucoside, cetearyl glucoside, isononyl isononanoate, pentaerythritol tetraester, polydimethylsiloxane, stearyl alcohol, hydroxystearic acid, polymethylsilsesquioxane, pentaerythritol distearate, and sucrose stearate.

[0029] The preservative includes at least one of 1,2-hexanediol, p-hydroxyacetophenone, phenoxyethanol, and propylparaben.

[0030] The pH adjuster includes at least one of citric acid, arginine, and EDTA-2Na.

[0031] The conditioning agent includes at least one of guar hydroxypropyltrimethylammonium chloride, polyquaternium-10, and panthenol.

[0032] The solubilizer includes at least one of hydrogenated castor oil and caprylic / capric glycerides.

[0033] The pearlescent agent includes at least one of ethylene glycol distearate and mica.

[0034] The surfactant includes at least one of sodium lauryl ether sulfate, cocamidopropyl betaine, cocamidomethyl MEA, lauryl ether-4 carboxylic acid, potassium cocoyl oat protein, sodium α-olefin sulfonate, and decyl glucoside.

[0035] Compared with the prior art, the beneficial effects of this application are as follows: (1) After extensive screening and verification, this application has determined the compound system of quaternary ammonium salt cationic emulsifier + specific nonionic emulsifier. Through the synergy of the above-mentioned specific surfactants, this application has achieved a breakthrough transformation of sulfur from particulate to molecular state, dissolving sulfur and uniformly freeing it in molecular form between the aqueous and oil phases. The molecular-level dispersion greatly improves the light transmittance of the system, and the sulfur composition exhibits a stable state with high light transmittance. (2) The sulfur composition of this application has high light transmittance, long-lasting stability and good antibacterial properties. When the sulfur composition of this application is prepared into shampoo, it has low irritation, good odor and good dandruff removal properties. When the sulfur composition of this application is prepared into shower gel, it has low irritation, good odor and good mite removal properties. Attached Figure Description

[0036] Figure 1 Figures are shown for the molecular sulfur compositions prepared in Examples 1 and 12; wherein, Figure 1 The diagram shows the molecular sulfur composition A prepared in Example 1. Figure 1 The medium molecular sulfur composition B is a diagram of the molecular sulfur composition prepared in Example 12; Figure 2 Figures showing the molecular sulfur compositions prepared in Examples 1 and 12 under transmitted light; wherein, Figure (a) is a diagram of the molecular sulfur composition prepared in Example 1 under transmitted light, and Figure (b) is a diagram of the molecular sulfur composition prepared in Example 12 under transmitted light. Figure 3 The images are of products containing molecular sulfur compositions, wherein Figure (c) is a transparent shower gel containing a molecular sulfur composition prepared using Example 1', and Figure (d) is a transparent shampoo containing a molecular sulfur composition prepared using Example 1. Figure 4 A diagram of a sulfur-containing shower gel prepared for Comparative Example 1'. Detailed Implementation

[0037] To better illustrate the purpose, technical solution, and advantages of this application, the following description, in conjunction with the accompanying drawings and specific embodiments, will further explain this application. The purpose is to provide a detailed understanding of the content of this application, not to limit it. All other embodiments obtained by those skilled in the art without inventive effort are within the protection scope of this application. Unless otherwise specified, the experimental reagents and instruments designed in the embodiments and comparative examples of this application are commonly used reagents and instruments, all of which are commercially available. Unless otherwise specified, the experimental methods used in the embodiments and comparative examples are conventional methods; and unless otherwise specified, the raw materials used in parallel experiments are from the same batch.

[0038] Further explanation of the raw materials used in this invention: Sulfur: Pharmaceutical grade sublimed sulfur.

[0039] Examples 1-17 and Comparative Examples 1-9 Examples 1-17 of this application each provide a sulfur composition. The components and weight parts of the sulfur compositions are selected as shown in Tables 1-3, with a total weight of 100 parts. In the sulfur compositions provided in Examples 1-17, the sulfur is in molecular form, and the preparation method is the same, including the following steps: S1. Weigh each component according to its weight parts; S2. Mix the quaternary ammonium salt cationic emulsifier, nonionic emulsifier and water evenly to obtain a mixed solution. Add sulfur to the mixed solution and heat to 95°C. After stirring evenly, cool to 25°C to obtain the molecular sulfur composition.

[0040] The preparation methods of the sulfur compositions provided in Comparative Examples 1-9 are the same as those in Examples 1-17, except that if the relevant components are not present, they can be omitted, and the additional components are prepared together with the emulsifier and water in step S2. Add the mixture. The hexadecyltrimethylammonium chloride, octadecyldimethylbenzylammonium chloride, AEO-9, AEO-7, OP-10, Span 80, and Tween 60 are added at S2.

[0041] Table 1 Table 2 Table 3 Example 18 This application provides a sulfur composition that is identical to that of Example 1 in terms of component selection and preparation method, except for the heating temperature. The preparation method includes the following steps: S1, weighing each component according to the weight parts; S2, mixing the quaternary ammonium salt cationic emulsifier, nonionic emulsifier and water evenly to obtain a mixed solution, adding sulfur to the mixed solution and heating to 80°C, stirring evenly and then cooling to 25°C to obtain the molecular sulfur composition.

[0042] Comparative Example 10 This application provides a sulfur composition in comparative example. Compared with Example 12, the component selection is exactly the same, the preparation method is basically the same, only the heating temperature is different. The preparation method includes the following steps: S1, weigh each component according to the weight parts; S2, mix the quaternary ammonium salt cationic emulsifier, nonionic emulsifier and water evenly to obtain a mixed solution, add sulfur to the mixed solution and heat to 75°C, stir evenly and then cool to 25°C to obtain the sulfur composition.

[0043] Shampoos prepared in Application Examples 1-19, Comparative Application Examples 1-10, and Blank Application Examples The present invention provides a shampoo in the form of an application example, a comparative application example, and a blank application example. The components (mass percentage) of the shampoo are shown in Table 4. The sulfur compositions used in Application Examples 1-18 were those prepared in Examples 1-18, respectively; the sulfur compositions used in Comparative Application Examples 1-10 were those prepared in Comparative Examples 1-10, respectively. For example, the sulfur composition used in Application Example 1 was the sulfur composition prepared in Example 1, the sulfur composition used in Application Example 2 was the sulfur composition prepared in Example 2, the sulfur composition used in Comparative Application Example 1 was the sulfur composition prepared in Comparative Example 1, and so on. The sulfur composition used in Application Example 19 was the sulfur composition prepared in Example 1.

[0044] The preparation method of the shampoo described in Application Example 1 of this invention includes the following steps, wherein the preparation methods of the shampoo provided in the other application examples, comparative application examples, and blank application examples are consistent with those in Application Example 1, and the relevant components are not added if they are not applicable: (1) Disperse guar gum hydroxypropyltrimethylammonium chloride evenly in water, then neutralize it completely with citric acid, and then add sodium lauryl ether sulfate, cocamidopropyl betaine, cocamidomethyl MEA, ethylene glycol distearate, and hydrogenated castor oil in sequence, and start stirring and heating. Heat to 95°C until completely dissolved, then stir and cool down; (2) Cool down to below 45°C, add daily fragrance, preservative and prepared sulfur composition in sequence and stir evenly to obtain the shampoo.

[0045] Table 4 Shower gels prepared using Application Examples 1'-19', Comparative Application Examples 1'-10', and Blank Application Example ' The present invention provides a shower gel in the application examples, comparative application examples and blank application examples, the components (mass percentage) of the shower gel are shown in Table 5; The sulfur compositions used in Application Examples 1'-18' were those prepared in Examples 1-18, respectively; the sulfur compositions used in Comparative Application Examples 1'-10' were those prepared in Comparative Examples 1-10, respectively. For example, the sulfur composition used in Application Example 1' was the sulfur composition prepared in Example 1, and the sulfur composition used in Application Example 2' was the sulfur composition prepared in Example 2; the sulfur composition used in Comparative Application Example 1' was the sulfur composition prepared in Comparative Example 1, and so on. The sulfur composition used in Application Example 19' was the sulfur composition prepared in Example 1.

[0046] The method for preparing the shower gel according to the present invention includes the following steps: the pH of the prepared shower gel is between 5 and 6. The preparation methods of the shower gels provided in the other application examples, comparative application examples, and blank application examples are consistent with those in application example 1; if the relevant components are not present, they can be omitted. 1. Mix phase A thoroughly and add it to phase B, dispersing it evenly at high speed. Add phases C, D, and E sequentially, stirring thoroughly after each addition (3 minutes). Stir and heat to 95°C until completely dissolved, then stir and cool to 45°C to obtain mixture X for later use.

[0047] 2. Stir and heat the F phase until it is completely dissolved, then stir and cool it down to 50°C for later use.

[0048] 3. Mix phase G thoroughly and stir rapidly. Add phase H to phase G until a uniform milky white emulsion is formed. Then add phase F and stir thoroughly to obtain mixture Y.

[0049] 4. Cool mixture Y to 45℃, add pre-treated mixture X, then add pre-dispersed phase J, and stir until homogeneous.

[0050] Table 5 Among them, DM Coilsi 001, from Dumei, includes hydrogenated polyisobutylene, hydrogenated polydecene and triheptene; 1% 0.7 million sodium hyaluronate is sodium hyaluronate powder diluted with deionized water to 1%.

[0051] Performance Test - 1 Transmittance Test Test samples: The sulfur compositions prepared in Examples 1-18 and Comparative Examples 1-10 were tested for light transmittance after being placed for 24 hours. Test method: Spectrophotometer method, 1cm cuvette; shake the sample well, and take the sample into the 1cm cuvette. Use distilled water as a reference and measure its transmittance at a wavelength of 560nm.

[0052] Meanwhile, the sulfur composition prepared in the examples was subjected to stability tests. The heat resistance test was conducted by standing at 48°C for 1 month and measuring its transmittance; the cold resistance test was conducted by standing at -15°C for 1 month and measuring its transmittance; the room temperature test was conducted by standing at 25°C for 1 month and measuring its transmittance; the thermal cycling test was conducted by storing the composition at 48°C, room temperature and -15°C for 24 hours each, cycling 10 times, and measuring its transmittance.

[0053] The test results are shown in Table 6.

[0054] Table 6 As shown in the table above, the sulfur composition prepared in the embodiments of the present invention has a light transmittance of over 85%, and molecular sulfur was obtained. Furthermore, the sulfur composition prepared in the embodiments of the present invention exhibits excellent stability. Experimental results show that after heat resistance, cold resistance, room temperature resistance, and thermal cycling tests, the light transmittance does not change significantly, with the change in light transmittance being within 1%. Figure 1 Figures are shown for the molecular sulfur compositions prepared in Examples 1 and 12; wherein, Figure 1 The diagram shows the molecular sulfur composition A prepared in Example 1. Figure 1 The medium molecular sulfur composition B is a diagram of the molecular sulfur composition prepared in Example 12; Figure 2 Images of the molecular sulfur compositions prepared in Examples 1 and 12 under transmitted light are shown; wherein, Figure (a) is an image of the molecular sulfur composition prepared in Example 1 under transmitted light, and Figure (b) is an image of the molecular sulfur composition prepared in Example 12 under transmitted light. Figure 1-2 As can be seen, the molecular sulfur composition B has lower light transmittance and contains some flocculent material.

[0055] As can be seen from the comparison of Examples 1-3, when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymediamine chloride but the ratio of the two is different, and the weight ratio of palmitamide propyltrimethylammonium chloride and hymediamine chloride is (2-4):1, the light transmittance is better.

[0056] As can be seen from the comparison of Examples 1 and 4-5, the transmittance is better when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymexazolium chloride, depending on the type of quaternary ammonium salt cationic emulsifier selected.

[0057] As can be seen from the comparison of Examples 1 and 6-7, when the nonionic emulsifier includes the first and second nonionic emulsifiers but the ratio of the two is different, the weight ratio of the first nonionic emulsifier and the second nonionic emulsifier is (1-2):1, which results in better light transmittance.

[0058] As can be seen from the comparison of Examples 1 and Examples 8-11, when the first nonionic emulsifier is PEG-7 glyceryl cocoate and the second nonionic emulsifier is di(PPG-2 myristyl alcohol polyether-10) adipate or di(PPG-3 myristyl ether) adipate, the light transmittance is better.

[0059] A comparison of Examples 1, 12-14, and 17 shows that when only one component is selected for both quaternary ammonium salt cationic emulsifier and nonionic emulsifier, molecular sulfur with a transmittance of over 85% can also be prepared.

[0060] A comparison of Examples 1 and 12-17 shows that the light transmittance is better when the mixture contains 1-2 parts of quaternary ammonium salt cationic emulsifier, 10-25 parts of nonionic emulsifier, 0.05-2 parts of sulfur, and 60-95 parts of water. Specifically, Example 15 has a lower sulfur content and higher transparency, while Example 16 has a higher sulfur content, resulting in decreased solubility of the emulsifier system and slightly lower transparency.

[0061] As can be seen from the comparison of Examples 1, 18, and Comparative Example 10, the temperature during the sulfur preparation process has a significant impact on the preparation of molecular sulfur. Molecular sulfur can be prepared at 80-105℃, with a light transmittance exceeding 85%. However, excessively high temperatures during sulfur preparation will produce harmful gases such as sulfur vapor, hydrogen sulfide, and sulfur dioxide. Conversely, excessively low temperatures will prevent the formation of molecular sulfur, resulting in poor light transmittance.

[0062] As can be seen from the comparison of Example 1 and Comparative Examples 1-7, when the quaternary ammonium salt cationic emulsifier and the nonionic emulsifier are not selected according to the specific types of this application, the prepared solution is turbid or layered, with a transmittance of less than 80%, and molecular sulfur cannot be prepared. As can be seen from the comparison of Example 1 and Comparative Examples 8-9, when either the quaternary ammonium salt cationic emulsifier or the nonionic emulsifier is missing, the prepared solution is turbid or layered, with a transmittance of less than 80%, and molecular sulfur cannot be prepared.

[0063] Performance Test - 2 Shampoo Test Test samples: Shampoos prepared in Application Examples 1-19, Comparative Application Examples 1-10, and Blank Application Examples; Test method: QTC-C-LAB-TOP-057 "In vitro test method for anti-dandruff efficacy of cosmetics (antibacterial loop method)"; Take 20uL of liquid sample, drop it onto a filter paper, and dry it for later use. Use a sterile cotton swab to absorb a concentration of 5.0×10 5 CFU / mL - 5.0 × 10 6 CFU / mL Malassezia furfur suspension was evenly spread three times on a suitable culture medium plate (average value). One infected plate was placed on each test, with four test specimens (average value) and one negative control specimen on each plate, for a total of five specimens. The plates were covered and incubated at (36±1)℃ for 72 hours. The results were then observed, and the diameter of the inhibition zone (including the specimen) was measured and recorded using calipers.

[0064] The test results are shown in Table 7. The average value of repeated tests was taken. In all tests, the negative control sample did not produce an inhibition zone. The test sample with an inhibition zone diameter > 7 mm was judged to have antibacterial effect; the sample with an inhibition zone diameter ≤ 7 mm was judged to have no antibacterial effect. If antibacterial effect was observed in 3 repeated tests (a total of 12 samples), the sample was judged to be qualified.

[0065] Table 7 As shown in the table above, the antibacterial ring diameter of the shampoo prepared in the application example of the present invention is >7mm. When the sulfur composition is applied to the shampoo, a trace amount of sulfur can be used to prepare a shampoo with an antibacterial ring diameter >7mm, which has excellent dandruff removal effect. Figure 3 Figure 1 shows a product containing a molecular sulfur composition, wherein Figure (d) shows a sulfur shampoo containing a molecular sulfur composition prepared in Application Example 1.

[0066] As can be seen from the comparison of application examples 1-3, when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymediamine chloride but the ratio of the two is different, and the weight ratio of palmitamide propyltrimethylammonium chloride and hymediamine chloride is (2-4):1, the antibacterial effect is better and the dandruff removal effect is better.

[0067] As can be seen from the comparison of Application Examples 1 and 4-5, the antibacterial effect is better and the dandruff removal effect is better when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymexazolium chloride.

[0068] As can be seen from the comparison of Application Examples 1 and 6-7, when the nonionic emulsifier includes the first and second nonionic emulsifiers but the ratio of the two is different, the weight ratio of the first nonionic emulsifier and the second nonionic emulsifier is (1-2):1, which has a better antibacterial effect and a better dandruff removal effect.

[0069] As can be seen from the comparison of Application Examples 1 and 8-11, when the first nonionic emulsifier is PEG-7 glyceryl cocoate and the second nonionic emulsifier is di(PPG-2 myristyl alcohol polyether-10) adipate or di(PPG-3 myristyl ether) adipate, the antibacterial effect is better and the dandruff removal effect is better.

[0070] As can be seen from the comparison of Application Examples 1, 12-14 and 17, when only one component is selected for both quaternary ammonium salt cationic emulsifier and nonionic emulsifier, molecular sulfur can also be prepared with good antibacterial and anti-dandruff effects.

[0071] A comparison of Application Examples 1 and 12-17 shows that a mixture of 1-2 parts quaternary ammonium salt cationic emulsifier, 10-25 parts nonionic emulsifier, 0.05-2 parts sulfur, and 60-95 parts water results in better antibacterial and dandruff-removing effects. In Application Example 15, the lower sulfur content resulted in a slightly weaker antibacterial effect, while Application Example 16, despite a decrease in the solubility of the emulsifier system, exhibited a better antibacterial effect due to its higher sulfur content.

[0072] As can be seen from the comparison of Application Example 1, Application Example 18, and Comparative Application Example 10, the temperature during the sulfur preparation process has a significant impact on the preparation of molecular sulfur. Molecular sulfur can be prepared at temperatures between 80-105℃, resulting in a shampoo with better dandruff-removing effects. However, if the temperature during sulfur preparation is too high, harmful gases such as sulfur vapor, hydrogen sulfide, and sulfur dioxide will be produced. Conversely, if the temperature is too low, molecular sulfur cannot be formed, resulting in poor dandruff-removing effects.

[0073] As can be seen from the comparison between Application Example 1 and Comparative Application Examples 1-7, when the quaternary ammonium salt cationic emulsifier and the nonionic emulsifier are not selected according to the specific types of this application, the prepared solution is either suspended or layered, and molecular sulfur cannot be prepared. As can be seen from the comparison between Application Example 1 and Comparative Application Examples 8-9, when either the quaternary ammonium salt cationic emulsifier or the nonionic emulsifier is missing, the prepared solution is either suspended or layered, and molecular sulfur cannot be prepared. When sulfur cannot be uniformly dispersed between the aqueous and oil phases in a molecular form and cannot form a molecular state, the antibacterial effect is poor, and it is determined to have no antibacterial effect.

[0074] Performance Test - 3 Shower Gel Test Test samples: Shower gels prepared in Application Examples 1'-19', Comparative Application Examples 1'-10', and Blank Application Example'; Test method: QTC-C-LAB-TOP-072 "In vitro test method for acne-removing efficacy of cosmetics (antibacterial rate method)"; Main equipment and reagents: biosafety cabinet, biochemical incubator, Clostridium enrichment medium, phosphate-buffered saline (PBS), standard strain: Propionibacterium acnes ATCC6919; Test steps: (1) Dilute the test bacterial suspension appropriately with PBS solution. The required concentration is: take 0.1 mL and drop it into 5.0 mL of control sample solution (PBS). The recovered bacterial count is 1 × 10⁻⁶. 4 ~9×10 4 CFU / mL; (2) Take 5 mL of the sample and put it into a sterile test tube. Take 0.1 mL of the above test bacterial solution and add it to the test tube containing 5 mL of sample. Mix quickly and start timing immediately. (3) After acting for 20 minutes, take 0.5 mL of the above mixture and add it to a test tube containing 4.5 mL of sterilized PBS, and mix thoroughly. (4) After standing for 10 minutes, take 1 mL of sample solution and place it in a sterile petri dish. Inoculate two sterile petri dishes with each sample solution. (5) Pour 15 mL of Clostridium enrichment medium cooled to 40°C into a Petri dish, rotate the Petri dish to mix it thoroughly, and after the medium solidifies, turn the Petri dish over and anaerobic culture in a 37°C constant temperature incubator for 72 h, and then count the viable colonies. (6) Replace the test sample with PBS and follow the above steps as a blank control group. Repeat the experiment 3 times and calculate the average value. (7) A negative control group (bacterial suspension, culture medium, sterile standard hard water) was also prepared for the experiment.

[0075] Results calculation: Inhibition rate (%) = (AB) / A × 100%; A represents the average colony count of the blank control sample; B represents the average colony count of the experimental group. As shown in Table 8.

[0076] Table 8 As shown in the table above, the antibacterial rate of the shower gel prepared in the application example of the present invention is >90%. When the sulfur composition is applied to the shower gel, a small amount of sulfur can be used to prepare a shower gel with an antibacterial rate of >90%, which has excellent antibacterial effect. Figure 3 Figure (c) shows a product containing a molecular sulfur composition, wherein the sulfur shower gel containing a molecular sulfur composition prepared using Example 1' is shown. Figure 4 The image shows a sulfur shower gel containing a sulfur composition prepared for Comparative Example 1'. The sulfur shower gel containing the sulfur composition is in a turbid liquid state.

[0077] As can be seen from the comparison of application examples 1'-3', when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymediamine chloride but the ratio of the two is different, and the weight ratio of palmitamide propyltrimethylammonium chloride and hymediamine chloride is (2-4):1, the antibacterial effect is better.

[0078] As can be seen from the comparison of Application Examples 1' and 4'-5', the antibacterial effect is better when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymexazolium chloride, depending on the type of quaternary ammonium salt cationic emulsifier selected.

[0079] As can be seen from the comparison of Application Examples 1' and 6'-7', when the nonionic emulsifier includes the first and second nonionic emulsifiers but the ratio of the two is different, the weight ratio of the first nonionic emulsifier and the second nonionic emulsifier is (1-2):1, which has a better antibacterial effect.

[0080] As can be seen from the comparison of Application Examples 1' and 8'-11', the antibacterial effect is better when the first nonionic emulsifier is PEG-7 glyceryl cocoate and the second nonionic emulsifier is di(PPG-2 myristyl alcohol polyether-10) adipate or di(PPG-3 myristyl ether) adipate.

[0081] A comparison of Application Examples 1', 12'-14', and 17' shows that when only one component is selected for both quaternary ammonium salt cationic emulsifier and nonionic emulsifier, molecular sulfur with good antibacterial effect can also be prepared.

[0082] A comparison of Application Examples 1' and 12'-17' shows that the antibacterial effect is better when the quaternary ammonium salt cationic emulsifier is 1-2 parts, the nonionic emulsifier is 10-25 parts, the sulfur is 0.05-2 parts, and the water is 60-95 parts. Among them, Application Example 15' has a lower sulfur content and a slightly weaker antibacterial effect, while Application Example 16', although the solubility of the emulsifier system is reduced, has a higher sulfur content and a better antibacterial effect.

[0083] A comparison of Application Example 1', Application Example 18', and Comparative Application Example 10' shows that the temperature during sulfur preparation significantly affects the preparation of molecular sulfur. Molecular sulfur can be prepared at 80-105℃, resulting in a shower gel with better antibacterial effects. However, excessively high temperatures during sulfur preparation produce harmful gases such as sulfur vapor, hydrogen sulfide, and sulfur dioxide, while excessively low temperatures prevent the formation of molecular sulfur, thus diminishing the antibacterial effect of the shower gel.

[0084] A comparison of Application Example 1' and Comparative Application Examples 1'-7 shows that when the quaternary ammonium salt cationic emulsifier and the nonionic emulsifier are not selected according to the specific types described in this application, the prepared solution is either suspended or layered, and molecular sulfur cannot be prepared. A comparison of Application Example 1' and Comparative Application Examples 8'-9 shows that when either the quaternary ammonium salt cationic emulsifier or the nonionic emulsifier is missing, the prepared solution is either suspended or layered, and molecular sulfur cannot be prepared. When sulfur cannot be uniformly dispersed between the aqueous and oil phases in a molecular form and cannot form a molecular structure, the antibacterial effect is poor.

[0085] Performance Test - 5 Shower Gel Mite Removal Test Test samples: Shower gels prepared in Application Examples 1'-19', Comparative Application Examples 1'-10', and Blank Application Example'; Test method: Mite removal: T / CIAA 017-2022 "Test Method and Evaluation of Mite-Removing Performance of Household Cleaning Products", where ≥90% is considered to have mite-removing effect. Sample pretreatment: Take 5g of shower gel, add mites, and observe after 48 hours. The control sample is deionized water; when the mite mortality rate in the control group is <5%, no correction is needed; when the mite mortality rate in the control group is 5%-20%, calculate the corrected mite eradication rate. Test mites: 203 in number, including house dust mites (Dermatophagoides farinae), adult males and females and nymphs; Testing environmental conditions: Temperature: (10-30)℃, Relative humidity: (35-80)%% The test results are shown in Table 9.

[0086] Table 9 As shown in the table above, the shower gel prepared in the application example of the present invention has a mite-killing rate of >90%. When the sulfur composition is applied to the shower gel, a small amount of sulfur can be used to prepare a shower gel with a mite-killing rate of >90%, which has excellent mite-removing effect.

[0087] As can be seen from the comparison of application examples 1'-3', when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymediamine chloride but the ratio of the two is different, and the weight ratio of palmitamide propyltrimethylammonium chloride and hymediamine chloride is (2-4):1, the mite removal effect is better.

[0088] As can be seen from the comparison of Application Examples 1' and 4'-5', the quaternary ammonium salt cationic emulsifier has a better mite-killing effect when the quaternary ammonium salt cationic emulsifier is a compound of palmitamide propyltrimethylammonium chloride and hymexazolium chloride.

[0089] As can be seen from the comparison of Application Examples 1' and 6'-7', when the nonionic emulsifier includes the first and second nonionic emulsifiers but the ratio of the two is different, the weight ratio of the first nonionic emulsifier to the second nonionic emulsifier is (1-2):1, which has a better mite removal effect.

[0090] As can be seen from the comparison of Application Examples 1' and 8'-11', when the first nonionic emulsifier is PEG-7 glyceryl cocoate and the second nonionic emulsifier is di(PPG-2 myristyl alcohol polyether-10) adipate or di(PPG-3 myristyl ether) adipate, the mite removal effect is better.

[0091] A comparison of Application Examples 1', 12'-14', and 17' shows that when only one component is selected for both quaternary ammonium salt cationic emulsifier and nonionic emulsifier, molecular sulfur can also be prepared with good mite-removing effect.

[0092] A comparison of Application Examples 1' and 12'-17' shows that a combination of 1-2 parts quaternary ammonium salt cationic emulsifier, 10-25 parts nonionic emulsifier, 0.05-2 parts sulfur, and 60-95 parts water results in better mite removal. Application Example 15', with its lower sulfur content, exhibits slightly weaker mite removal performance, while Application Example 16', despite a decrease in emulsifier system solubility, demonstrates better mite removal due to its higher sulfur content.

[0093] A comparison of Application Example 1', Application Example 18', and Comparative Application Example 10' shows that the temperature during sulfur preparation significantly affects the preparation of molecular sulfur. Molecular sulfur can be prepared at 80-105℃, resulting in a shower gel with better mite-removing effects. However, excessively high temperatures during sulfur preparation produce harmful gases such as sulfur vapor, hydrogen sulfide, and sulfur dioxide, while excessively low temperatures prevent the formation of molecular sulfur, leading to a poor mite-removing effect in the shower gel.

[0094] A comparison of Application Example 1' and Comparative Application Examples 1'-7 shows that when the quaternary ammonium salt cationic emulsifier and the nonionic emulsifier are not selected according to the specific types described in this application, the prepared solution is either suspended or layered, and molecular sulfur cannot be prepared. A comparison of Application Example 1' and Comparative Application Examples 8'-9 shows that when either the quaternary ammonium salt cationic emulsifier or the nonionic emulsifier is missing, the prepared solution is either suspended or layered, and molecular sulfur cannot be prepared. When sulfur cannot be uniformly dispersed between the aqueous and oil phases in a molecular form and cannot form a molecular structure, the mite-killing effect is poor.

[0095] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit the scope of protection of this application. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the substance and scope of the technical solutions of this application.

Claims

1. A sulfur composition, characterized in that, The composition comprises the following components in parts by weight: 0.5-5 parts of quaternary ammonium salt cationic emulsifier, 5-30 parts of nonionic emulsifier, 0.05-2 parts of sulfur, and 60-95 parts of water; the transmittance of the sulfur composition is ≥85%. The quaternary ammonium salt cationic emulsifier includes at least one of palmitamidopropyltrimethylammonium chloride, hymediamine chloride, and undecenoylamidopropyltrimethylammonium methyl sulfate; The nonionic emulsifier includes at least one of PEG-7 glyceryl cocoate, di(PPG-2 myristyl alcohol polyether-10) adipate, di(PPG-3 myristyl ether) adipate, polyglycerol-4 lauryl ester, PEG-6 caprylic / capric glycerides, and lauryl alcohol polyether-4.

2. The sulfur composition according to claim 1, characterized in that, It includes the following components in parts by weight: 1-2 parts of quaternary ammonium salt cationic emulsifier, 10-25 parts of nonionic emulsifier, 0.05-2 parts of sulfur, and 60-95 parts of water.

3. The sulfur composition according to claim 1, characterized in that, The weight ratio of the quaternary ammonium salt cationic emulsifier to the nonionic emulsifier is 1:(10-15).

4. The sulfur composition according to claim 1, characterized in that, The quaternary ammonium salt cationic emulsifier is a compound of palmitamidopropyltrimethylammonium chloride and hymediamine chloride; the weight ratio of palmitamidopropyltrimethylammonium chloride and hymediamine chloride is (2-4):

1.

5. The sulfur composition according to claim 1, characterized in that, The nonionic emulsifier includes a first nonionic emulsifier and a second nonionic emulsifier; the first nonionic emulsifier is PEG-7 glyceryl cocoate, and the second nonionic emulsifier is di(PPG-2 myristyl alcohol polyether-10) adipate or di(PPG-3 myristyl ether) adipate; the weight ratio of the first nonionic emulsifier to the second nonionic emulsifier is (1-2):

1.

6. A method for preparing a sulfur composition according to any one of claims 1-5, characterized in that, Includes the following steps: S1. Weigh each component according to the above-mentioned weight proportions; S2. Mix the quaternary ammonium salt cationic emulsifier, nonionic emulsifier and water evenly to obtain a mixed solution. Add sulfur to the mixed solution and heat to 80-105℃. After stirring evenly, cool to 25-30℃ to obtain the sulfur composition.

7. The use of a sulfur composition as described in any one of claims 1-5 in the preparation of cleaning products.

8. A cleaning product, characterized in that, The cleaning products include the sulfur composition as described in any one of claims 1-5.

9. The cleaning product as described in claim 8, characterized in that, The cleaning products include at least one of skin cleaning and care products, fabric cleaning and care products, and animal cleaning and care products.

10. The cleaning product as described in claim 8, characterized in that, The cleaning product comprises the following components by weight percentage: 0.05-2% of the sulfur composition according to any one of claims 1-5, 1-40% of the matrix, and the balance being water.

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