Method for treating dermatitis caused by unknown reasons

Abstract

Dermatitis is a common skin disease, patients often suffer from strong pruritus, pain, many exudates and easy relapse in the later period, and although the prior art has a certain curative effect, the prior art has the defects of long healing time, low curative effect, slow wound healing speed and the like. The invention provides a method for rapidly treating dermatitis caused by unknown reasons, which is low in treatment cost, wide in raw material source, simple in medicament preparation, good in curative effect and capable of rapidly treating dermatitis caused by unknown reasons. The technical scheme is as follows: the mass ratio of sulfur to rapeseed oil to roxithromycin is (0.7-1.3): (4.7-5.3): (0.17-0.23); wherein the sulfur is crushed and then sieved by a 80-100-mesh sieve, the three raw materials are uniformly mixed according to a ratio and are used immediately after being prepared, and when the dermatitis is treated, the affected part of the skin is cleaned and disinfected by using a 3.0-3.5% hydrogen peroxide solution, is uniformly coated with a compound medicament and then is bound by using sterile gauze, and the medicament is changed once every 0.5 days after primary treatment until the dermatitis is cured.

Description

Technical Field

[0001] This invention relates to the field of biopharmaceuticals, specifically to a method for treating dermatitis of unknown cause, particularly suitable for treating dermatitis that is not well treated with Western medicine and is prone to recurrence. Background Technology

[0002] Dermatitis is a common skin disease, accounting for approximately 15% to 30% of dermatology outpatient visits, with acute eczematous dermatitis being particularly prevalent. Initial clinical symptoms include redness, swelling, papules, itching, and pain. In the middle stage, the papules develop into vesicles ranging in size from a rapeseed to a soybean. In the later stage, the vesicles merge into patches and may even rupture and ooze fluid. There are many causes of dermatitis, commonly including allergies, infections, and irritants. Allergic dermatitis is caused by an overreaction to a certain sensitizing substance, such as contact with cosmetics or certain foods. Infectious dermatitis is caused by skin infections resulting from bacteria, viruses, or fungi. Irritant dermatitis is caused by physical, chemical, or biological irritants in the external environment, such as sun exposure, cold, dry climates, and friction. In clinical practice, the exact cause of many cases of dermatitis is difficult to determine, and some are even related to genetic factors. Because this disease often involves intense itching, abundant exudate, and is prone to recurrence, patients with long-term, recurrent flare-ups suffer greatly. Currently, clinical treatment for these diseases often employs anti-allergy, sedative, and hormonal medications, such as hydrocortisone acetate ointment, triamcinolone ointment, clobetasol ointment, and dermatitis ointment. Long-term use of these Western medicines easily leads to drug resistance and has significant side effects, making it difficult to fundamentally solve the recurrence problem. Regarding traditional Chinese medicine treatment, the treatment schemes disclosed in invention patents CN121197263A, CN121265677A, CN121177423A, and CN120960307A, while having fewer side effects and some efficacy, suffer from drawbacks such as long healing time, low efficacy, slow wound healing, limited availability of medicinal components, difficulty in obtaining materials, complex preparation of the medicine, and a high recurrence rate after wound healing. Therefore, it is essential to develop a method that is convenient to obtain materials, simple to prepare, and has a significant curative effect. Summary of the Invention

[0003] To overcome the shortcomings of existing technologies, this invention provides a method for treating dermatitis of unknown cause that is low in treatment cost, has a wide range of raw material sources, is simple to prepare, has good efficacy, short cure time, and can quickly treat dermatitis of unknown cause. The technical solution is: a method for treating dermatitis of unknown cause, comprising sulfur, rapeseed oil, and roxithromycin, characterized in that the mass ratio of sulfur, rapeseed oil, and roxithromycin is 0.7–1.3:4.7–5.3:0.17–0.23.

[0004] The preferred ratio is 1:5:0.2 for sulfur, rapeseed oil, and roxithromycin.

[0005] Furthermore, in the above-mentioned method for treating dermatitis of unknown cause, the sulfur is processed "prepared sulfur" slices purchased from a traditional Chinese medicine pharmacy, which are then pulverized and passed through an 80-100 mesh sieve; the rapeseed oil is commercially available small-batch pressed rapeseed oil; and the roxithromycin is commercially available roxithromycin capsules.

[0006] Furthermore, sulfur, rapeseed oil, and roxithromycin are mixed evenly in a specific ratio and prepared immediately before use.

[0007] Furthermore, when treating dermatitis, first clean and disinfect the affected skin area with a 3.0%–3.5% hydrogen peroxide solution, then evenly apply the compound medication and bandage it with sterile gauze.

[0008] Furthermore, the dressing should be changed every 0.5 days after the initial treatment until the patient is fully recovered.

[0009] The evaluation criteria for the clinical efficacy of this invention are slightly modified from the "Guiding Principles for Clinical Research of Important New Drugs". Specifically: Cured: After treatment, clinical symptoms such as skin redness, swelling, papules, itching, and pain disappear, and skin color returns to normal; Significantly Effective: After treatment, symptoms are significantly improved, itching and pain symptoms basically disappear, and the area of ​​skin redness, swelling, and papules returning to normal exceeds 2 / 3; Effective: Clinical symptoms improve compared to before treatment, skin color improves, itching and pain symptoms are relieved, and the area of ​​skin redness, swelling, and papules returning to normal exceeds 1 / 2 but is less than 2 / 3; Ineffective: Does not meet the above criteria.

[0010] The clinical trial results of this invention are expressed using "calcium squared (X)". 2 The test involves statistical processing of the relevant experimental data.

[0011] The experimental materials for this invention were as follows: sulfur was processed sulfur slices purchased from a traditional Chinese medicine pharmacy; rapeseed oil was commercially available small-batch pressed rapeseed oil; roxithromycin capsules were commercially available and produced by Zhuhai Federal Pharmaceutical Co., Ltd., Zhongshan Branch; physiological saline was commercially available; and the control drug "Piyanping" was commercially available and produced by China Resources Sanjiu Pharmaceutical Co., Ltd. During the experiment, the sulfur was pulverized and passed through a 100-mesh sieve. According to the experimental design, sulfur, rapeseed oil, and roxithromycin were mixed evenly in proportion to form a coating.

[0012] In the clinical trial observation group of this invention, the compound medication provided by the inventor was used for treatment. Specifically, when treating dermatitis, the wound was first cleaned and disinfected with a 3.0%–3.5% hydrogen peroxide solution, the compound medication was applied, and then the wound was bandaged with sterile gauze. After the initial treatment, the dressing was changed every 0.5 days until the affected skin returned to normal. The control group was treated with traditional Western medicine methods. Specifically, when treating dermatitis, the wound was first cleaned with 3.0%–3.5% hydrogen peroxide, then "Piyanping" ointment was applied evenly, and then the wound was bandaged with sterile gauze. The dressing was changed every 0.5 days. The treatment effect was observed and recorded before each dressing change. A blank control group using physiological saline was also included.

[0013] To reduce experimental errors, the single-dose treatment effect observation experiment and the binary and ternary compound preparations compared with traditional Western medicine treatments of this invention are conducted in two replicates, using different affected areas of the same patient's body as the observation subjects. For example, in the comparison of the single-dose treatment effect of this invention, the affected areas of the same patient's left arm, right arm, left leg, right leg, back, and abdomen are used as the observation subjects.

[0014] To reduce the workload of textual description, this invention uses symbols to replace some textual statements. The textual meanings of the symbols in the tables of this article are shown in Table 1.

[0015] The results of the single-dose trial of this invention for treating mild early-stage dermatitis are shown in Table 2. Table 3 shows a comparison of the therapeutic effects of the binary and ternary compound formulations of this invention on patients with severe late-stage dermatitis. Table 1. Meaning of the symbols in the tables in this article

[0016] Note: In the tables of this article, the lowercase letters following the statistics on the duration of recovery (in days) indicate that the statistical analysis shows no significant difference between the two groups, while the lowercase letters indicate that the statistical analysis shows a significant difference between the two groups. " / " indicates that there was no improvement trend by the end of the experiment, and the duration of recovery was not counted.

[0017] The results in Table 2 show that for patients with mild dermatitis, saline (control area) further aggravated the dermatitis, while the sulfur single-agent area (formula A) only slowed the progression of dermatitis and could not effectively control the development of the disease. Single-agent rapeseed oil and roxithromycin had no therapeutic effect. The binary combination of sulfur and rapeseed oil had a better therapeutic effect than either single agent, and there was a significant synergistic and synergistic effect between the two. There was no significant difference in efficacy between the binary combination of sulfur and rapeseed oil and the ternary combination of sulfur, rapeseed oil and roxithromycin containing antibiotics for patients with early-stage mild dermatitis.

[0018] Table 3 shows that for patients with severe dermatitis, saline solution (control area) further aggravated the dermatitis. In the conventional control area, while "Piyanping" (a topical anti-inflammatory cream) provided some relief from itching and pain at the beginning of treatment, its astringent effect on herpes was poor, and the healing time was long, nearly a month. The treatment area treated with the "sulfur, rapeseed oil, and roxithromycin" ternary compound showed rapid healing, with near-complete recovery after 6 days of application. The treatment area treated with the antibiotic-free "sulfur and rapeseed oil" binary compound, although providing relief from itching and pain, did not show as good astringent and crust-forming effects as the antibiotic-containing ternary compound treatment area, requiring 9 days for near-complete recovery. It can be seen that the antibiotic-containing "sulfur powder, rapeseed oil, and roxithromycin" ternary compound has a better therapeutic effect and a shorter healing time for severe dermatitis. This indicates that although the binary combination of sulfur and rapeseed oil has a synergistic effect in the treatment of early-stage dermatitis (the synergistic effect is slightly weaker for severe dermatitis), the combination of sulfur, rapeseed oil, and roxithromycin shows a better synergistic effect in the treatment of severe patients in the later stages of dermatitis.

[0019] The results of the small-area clinical trial of this invention are shown in Table 4. As shown in Table 4, the C formula group of this invention, namely the sulfur, rapeseed oil, and roxithromycin 1:5:0.2 group, had significantly higher cure rates and total effective rates than the conventional Western medicine control group, significantly lower ineffective rates, and significantly shorter cure times. No side effects were observed. This indicates that the C formula of this invention is safe and effective.

[0020] In summary, the present invention, "A method for treating dermatitis of unknown cause," specifically the formula of "sulfur, rapeseed oil, and roxithromycin in a mass ratio of 0.7–1.3:4.7–5.3:0.17–0.23," utilizes widely available raw materials, is low in cost, pollution-free, simple to prepare, convenient to use, and results in a short treatment time, good efficacy, rapid wound healing, and no side effects. Satisfactory results have been achieved in clinical treatment of dozens of patients. It is the preferred technical solution for treating dermatitis of unknown cause. Detailed Implementation

[0021] The present invention will be further illustrated by specific embodiments below, but the following embodiments are only for illustrating the present invention and do not limit the present invention. Example

[0022] Purchase sulfur, locally pressed rapeseed oil, and roxithromycin from the market. The sulfur is pulverized and passed through an 80-mesh sieve. Mix the sulfur thoroughly in a mass ratio of 0.7:4.7:0.17, and prepare the solution immediately before use. When treating dermatitis patients, first clean the wound with 3.0% hydrogen peroxide. Then, apply the pre-mixed solution evenly to the wound with a sterile cotton ball, and bandage with sterile gauze. Change the dressing every half day until healed. Example

[0023] Purchase sulfur, locally pressed rapeseed oil, and roxithromycin from the market. The sulfur is pulverized and passed through a 90-mesh sieve. Mix the sulfur thoroughly in a mass ratio of 1:5:0.2, and prepare immediately before use. When treating dermatitis patients, first clean the wound with 3.3% hydrogen peroxide. Then, apply the pre-mixed compound solution evenly to the wound with a sterile cotton ball, and bandage with sterile gauze. Change the dressing every half day until healed. Example

[0024] Purchase sulfur, locally pressed rapeseed oil, and roxithromycin from the market. The sulfur is pulverized and passed through a 100-mesh sieve. Mix the sulfur thoroughly in a mass ratio of 1.3:5.3:0.23, and prepare immediately before use. When treating dermatitis patients, first clean the wound with 3.5% hydrogen peroxide. Then, apply the pre-mixed compound solution evenly to the wound with a sterile cotton ball, and bandage with sterile gauze. Change the dressing every half day until healed.

[0025] Table 2: Comparison of single-dose treatment effects of the present invention (patients with mild initial symptoms)

[0026] Note: To minimize experimental error, different affected areas of the same dermatitis patient were selected as observation subjects. Patient 1, Mr. Zhang, 56 years old, male, from Tinghu District, Yancheng City, Jiangsu Province, underwent a clinical efficacy trial on the third day after the onset of red and itchy skin due to dermatitis. Patient 2, Ms. Liu, 39 years old, female, from Yandu District, Yancheng City, Jiangsu Province, also underwent a clinical efficacy trial on the third day after the onset of red and itchy skin due to dermatitis. The experiment was conducted in July 2021. "↑" and "↓" indicate slight aggravation or improvement of related symptoms compared to the previous observation. The same applies to the following tables.

[0027] Table 3: Comparison of therapeutic effects between the binary and ternary compound formulations of this invention (for patients with severe late-stage illness).

[0028] Note: To minimize experimental error, two patients with the same dermatitis but different affected areas were selected for observation. Patient 1, Mr. Lu, 62 years old, from Tinghu District, Yancheng City, Jiangsu Province, underwent a drug efficacy test on the seventh day after the onset of red and itchy skin due to dermatitis. Patient 2, Ms. Li, 47 years old, from Yandu District, Jiangsu Province, also underwent a drug efficacy test on the seventh day after the onset of red and itchy skin due to dermatitis. In contrast, in the conventional treatment area (CK2), the blisters only subsided on the 22nd day, scabs formed on the 26th day, and the area was basically healed on the 28th day. The experiment was conducted in August 2022. * indicates a significant difference in CK2 between the invention group and the traditional Western medicine control group; ** indicates an extremely significant difference in CK2 between the invention group and the traditional Western medicine control group.

[0029] Table 4: Results of small-area clinical trial of the present invention

[0030] Note: * indicates a significant difference in CK2 between the invention group and the traditional Western medicine control group; ** indicates an extremely significant difference in CK2 between the invention group and the traditional Western medicine control group. The experiment was conducted in September 2025. "Cure duration" refers to the time from the start of medication to the skin returning to normal. The experiment was conducted at Yandong Town Hospital and Huangjian Town Hospital in Tinghu District, Yancheng City.

Claims

1. A method for treating dermatitis of unknown cause, comprising sulfur, rapeseed oil, and roxithromycin, characterized in that: The mass ratio of sulfur, rapeseed oil, and roxithromycin is 0.7–1.3: 4.7–5.3: 0.17–0.

23.

2. The method for treating dermatitis of unknown cause according to claim 1, characterized in that: The mass ratio of sulfur, rapeseed oil, and roxithromycin is 1:5:0.

2.

3. The method for treating dermatitis of unknown cause according to claim 2, characterized in that: The sulfur was processed "processed sulfur" slices purchased from a traditional Chinese medicine pharmacy, which were then crushed and passed through an 80-100 mesh sieve. The rapeseed oil was commercially available small-batch pressed rapeseed oil. The roxithromycin was commercially available roxithromycin capsules.

4. A method for treating dermatitis of unknown cause according to claim 1 or claim 2, characterized in that: Sulfur, rapeseed oil, and roxithromycin are mixed evenly in the specified proportions and prepared for immediate use.

5. A method for treating dermatitis of unknown cause according to claim 1 or claim 2, characterized in that: When treating dermatitis, first clean and disinfect the wound with a 3.0% to 3.5% hydrogen peroxide solution, then apply the compound medication evenly and bandage it with sterile gauze.

6. A method for treating dermatitis of unknown cause according to claim 1 or claim 2, characterized in that: After the initial treatment, the dressing should be changed every 0.5 days until the patient is fully recovered.

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