Reusable traditional Chinese medicine external treatment conditioning ointment as well as preparation method and application thereof

Abstract

The embodiment of the invention discloses a reusable traditional Chinese medicine external treatment conditioning ointment as well as a preparation method and application thereof. The ointment is composed of core medicinal and edible raw materials and auxiliary materials, the core medicinal and edible raw materials comprise 17 medicinal and edible components such as zaocys dhumnade, agkistrodon halys, safflower and old ginger, and the auxiliary materials comprise 6 safe raw materials such as honey, glycerin and maltose. According to the ointment, the core raw materials are high in safety, the dissolution rate of effective components is increased after fermentation, the ointment has appropriate viscosity and toughness, and the ointment is matched with two use modes of heating hot compress and plaster application, can specifically condition uncomfortable parts of shoulders, necks, waists, abdomens and joints of a human body, and has the effects of promoting blood circulation to remove blood stasis and relaxing tendons and activating collaterals; the traditional Chinese medicine composition can be repeatedly used for 10-28 times (in a hot compress mode) or 3 times (in a paste mode), the use cost is effectively reduced, the resource waste is reduced, the preparation process is simple and convenient, large-scale production is easy, and the good application prospect is achieved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a reusable external treatment ointment made from traditional Chinese medicine, its preparation method, and its application. Background Technology

[0002] External application of traditional Chinese medicine is an important component of traditional Chinese medicine therapies. It boasts advantages such as direct targeting of the affected area, rapid onset of action, and minimal side effects, and is widely used to treat symptoms such as musculoskeletal discomfort and blood stasis. With increasing health awareness, the demand for safe, convenient, and flexible external application products of traditional Chinese medicine is growing daily.

[0003] Most of the traditional Chinese medicine external treatment ointments on the market are single-use products that are discarded after use. This not only increases the user's cost but also wastes resources. At the same time, some products have problems such as insufficient safety of ingredients (e.g., the addition of irritating chemical ingredients), improper viscosity control (too thin and it will flow easily or too thick and it will not adhere well), insufficient toughness (easily damaged and difficult to reapply), and limited usage methods. These issues fail to meet the needs of different users in different scenarios, affecting the user experience and treatment effect.

[0004] Food-medicine homologous substances possess both medicinal value and food safety. Applying them to the preparation of traditional Chinese medicine external treatment ointments can effectively improve the safety and versatility of the products. However, current technologies for the synergistic regulation of fermentation processes for food-medicine homologous substances and the viscosity and toughness of external ointments are still imperfect. Furthermore, there is a lack of reusable, safe, and stable traditional Chinese medicine external treatment ointments suitable for various application scenarios. Therefore, developing a reusable conditioning ointment based on food-medicine homologous substances with flexible application methods has become an urgent need in the field of traditional Chinese medicine external treatment. Summary of the Invention

[0005] Therefore, this invention provides a reusable traditional Chinese medicine external treatment ointment, its preparation method, and its application, to solve the defects of existing traditional Chinese medicine external treatment ointments, such as high cost of single use, insufficient safety of ingredients, unsuitable viscosity and toughness, and limited usage methods.

[0006] To achieve the above objectives, the embodiments of the present invention provide the following technical solutions:

[0007] According to a first aspect of the present invention, the present invention provides a reusable traditional Chinese medicine external treatment ointment, which is composed of core medicinal and edible raw materials and excipients. By weight, the core medicinal and edible raw materials include 2-6 parts of black-striped snake, 2-6 parts of viper, 2-6 parts of safflower, 2-6 parts of old ginger, 2-6 parts of angelica dahurica, 2-6 parts of papaya, 2-6 parts of cinnamon, 2-6 parts of Sichuan pepper, 2-6 parts of peach kernel, 2-6 parts of angelica sinensis, 2-6 parts of chuanxiong rhizome, 2-6 parts of salvia miltiorrhiza, 2-6 parts of eucommia ulmoides, 2-6 parts of cinnamon bark, 2-6 parts of achyranthes bidentata, 2-6 parts of coix seed, and 2-6 parts of poria cocos. The excipients include 10-15 parts of honey, 5-8 parts of glycerin, 8-12 parts of maltose, 3-5 parts of liquid paraffin, 4-6 parts of edible oil, and 1-2 parts of camphor.

[0008] Furthermore, the edible oil is selected from one or more of soybean oil, peanut oil, and sesame oil.

[0009] According to a second aspect of the present invention, the present invention provides a method for preparing the reusable traditional Chinese medicine external treatment ointment as described above, comprising the following steps:

[0010] (1) Clean the core medicinal and edible raw materials, remove impurities, dry them, and pulverize them into coarse powder of 20-40 mesh;

[0011] (2) Add deionized water to the coarse powder from step (1) and then inoculate with compound fermentation bacteria. Ferment at a constant temperature of 28-32℃ for 3-5 days, stirring regularly during the process.

[0012] (3) The fermented material obtained in step (2) is vacuum dried and then pulverized into 100-120 mesh fine powder to obtain fermented medicine powder;

[0013] (4) Heat the honey to 45°C, remove the foam on the surface, and obtain melted honey; mix maltose powder and deionized water at a mass ratio of 1:0.9, heat and stir until completely dissolved, and obtain maltose solution; heat soybean oil to 65°C, keep it at a constant temperature for 10 minutes, and cool it to room temperature to obtain refined edible oil.

[0014] (5) The fermented medicinal powder from step (3), the melted honey, maltose solution, glycerin, liquid paraffin, refined edible oil, and camphor from step (4) are mixed and stirred evenly in sequence, placed in a mold, kept at a constant temperature, cooled and demolded to obtain the reusable Chinese herbal external treatment ointment.

[0015] Further, in step (2), the amount of deionized water added is 1.2-1.5 times the total weight of the core medicinal and edible raw materials, and the compound fermentation bacteria are made by mixing brewing yeast and lactic acid bacteria in a mass ratio of 1:1, with an inoculation amount of 0.5-1% of the total weight of the core medicinal and edible raw materials.

[0016] Furthermore, in step (3), the vacuum drying conditions are 50-60℃ and vacuum degree 0.06-0.08MPa, and the material is dried until the moisture content is ≤8%.

[0017] Further, in step (5), the stirring conditions are: 40-60℃, 150-200r / min, 20-30 minutes; the constant temperature standing conditions are: 30-35℃, 2.5-3 hours.

[0018] Furthermore, the method also includes: placing the used traditional Chinese medicine external treatment ointment in a sealed iron can, soaking it in 80-100℃ hot water for 20-25 minutes for high-temperature sterilization, and then drying it for reuse.

[0019] According to a third aspect of the present invention, the present invention provides the application of the reusable traditional Chinese medicine external treatment ointment as described above in the preparation of a medicine for treating discomfort in the shoulders, neck, waist, abdomen, and joints of the human body.

[0020] The embodiments of the present invention have the following advantages:

[0021] (1) The core raw materials of this invention are all food and medicine homologous substances. After fermentation, they are mild and non-irritating. The excipients are all common food-grade or pharmaceutical-grade raw materials, which are highly safe and suitable for people of different ages (except pregnant women and those with broken skin).

[0022] (2) The ointment of the present invention has good toughness and stability. After use, it can be reused 10-28 times after being sterilized and dried at a specified high temperature, which effectively reduces the user's cost and reduces resource waste.

[0023] (3) The core medicinal and food homologous ingredients of this invention work synergistically. After fermentation, the dissolution rate of the effective ingredients is increased. Combined with the heating and enhanced use method, it can further promote the absorption of the effective ingredients by the skin. When applied externally to the body to the uncomfortable parts, it can fully exert the conditioning effect of promoting blood circulation, removing blood stasis, relaxing muscles and tendons, and relieving symptoms such as muscle soreness and joint discomfort.

[0024] (4) The ointment of the present invention has moderate viscosity and toughness, and is suitable for both heating and plaster application. It meets the needs of deep conditioning at home and is convenient to use when going out. There is no foreign body sensation during use, and it is easy to clean without leaving any stains.

[0025] (5) The preparation process of the present invention does not require complex equipment, the operation steps are simple, and it is easy to scale up production. Detailed Implementation

[0026] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] Example 1

[0028] This embodiment provides a reusable traditional Chinese medicine external treatment ointment:

[0029] 1. Raw material preparation (by weight):

[0030] Core medicinal and edible ingredients: 4 parts each of black-striped snake, viper, safflower, old ginger, angelica dahurica, papaya, cinnamon, Sichuan pepper, peach kernel, angelica sinensis, chuanxiong rhizome, salvia miltiorrhiza, eucommia ulmoides, cinnamon bark, achyranthes bidentata, coix seed, and poria cocos.

[0031] Ingredients: 12 parts honey, 6 parts glycerin, 10 parts maltose powder, 4 parts liquid paraffin, 5 parts soybean oil, 1.5 parts camphor;

[0032] 0.8 parts of compound fermentation bacteria (sacchariculture yeast and lactic acid bacteria in a weight ratio of 1:1).

[0033] 2. Preparation steps:

[0034] (1) Pretreatment of main ingredients: Clean the above-mentioned core medicinal and edible raw materials, remove impurities, and place them in a ventilated and dry place (temperature 35℃) to dry for later use.

[0035] (2) Fermentation treatment: After drying, the raw materials are crushed into 30-mesh coarse powder, mixed evenly, and then deionized water (1.3 times the total weight of the main materials) is added. The mixture is stirred evenly, and compound fermentation bacteria are introduced. The mixture is fermented at a constant temperature of 30℃ for 4 days, and stirred twice a day for 12 minutes each time to obtain fermented material.

[0036] (3) Powder preparation: The fermented material is placed in a vacuum drying oven and dried at 55°C and 0.07MPa vacuum until the moisture content is 6%. Then it is pulverized into 110-mesh fine powder and sieved to obtain fermented medicine powder.

[0037] (4) Pretreatment of auxiliary materials: Heat the honey to 45°C to melt it and remove the foam on the surface; add maltose powder to deionized water (0.9 times the weight of maltose powder), heat and stir until completely dissolved to make maltose solution; heat soybean oil to 65°C, keep it at a constant temperature for 10 minutes, and cool it to room temperature for later use.

[0038] (5) Mixing and molding: Add the fermented medicine powder to the mixing pot, then add the melted honey, maltose solution, glycerin, liquid paraffin and pretreated soybean oil in sequence. Stir at 180 r / min for 25 minutes. Finally, add camphor ground to 90 mesh fine powder and continue stirring for 12 minutes. Place the evenly mixed material in a round molding mold and let it stand at a constant temperature of 35℃ for 2.5 hours. After cooling to room temperature, demold to obtain a reusable ointment with a diameter of 5 cm and a thickness of 0.5 cm.

[0039] 3. Product testing: The prepared ointment has a moderate viscosity, is not sticky to the touch, and does not easily fall off after being applied to the skin; it has good toughness, and can return to its original shape after being stretched to 1.5 times its original length without damage; after being sterilized at a specified high temperature, there are no residual stains or harmful microorganisms on the surface, and it can be reused after drying.

[0040] 4. Instructions for use:

[0041] Method 1: Take 300-800g of the above ointment and spread it evenly on the uncomfortable area of ​​the neck and shoulders (0.4cm thick). Cover it with a sterile plastic film and heat it with a 42℃ hot compress for 50 minutes. After heating, remove the hot compress and plastic film, place the ointment in a sealed iron can with a sealing ring, and heat it in 90℃ hot water for 20 minutes for high-temperature sterilization. After drying, it can be reused.

[0042] Method 2: Take 10-30g of the above ointment, spread it evenly on a 5cm×8cm sterile non-woven fabric (0.25cm thickness) to make a plaster, apply it to the uncomfortable area of ​​the waist and abdomen, and remove it after 6 hours; place the ointment in a sealed iron can with a sealing ring, heat it in 90℃ hot water for 20 minutes for high-temperature sterilization, and it can be reused after drying.

[0043] 5. Reusability: Option 1: This ointment can be reused 10-28 times. The effect is stable during the first 10 uses, but the efficacy slightly weakens after the 11th use. It is recommended to replace it with a new ointment after the 28th use. Option 2: Can be reused 3 times.

[0044] Example 2

[0045] This embodiment provides a reusable traditional Chinese medicine external treatment ointment:

[0046] 1. Raw material preparation (by weight):

[0047] Core medicinal and edible ingredients: 2 parts of black-striped snake, 2 parts of viper, 2 parts of safflower, 2 parts of old ginger, 2 parts of angelica dahurica, 2 parts of papaya, 2 parts of cinnamon, 2 parts of Sichuan pepper, 2 parts of peach kernel, 2 parts of angelica sinensis, 2 parts of chuanxiong rhizome, 2 parts of salvia miltiorrhiza, 2 parts of eucommia bark, 2 parts of cinnamon bark, 2 parts of achyranthes bidentata, 2 parts of coix seed, and 2 parts of poria cocos;

[0048] Ingredients: 10 parts honey, 5 parts glycerin, 8 parts maltose powder, 3 parts liquid paraffin, 4 parts peanut oil, 1 part camphor;

[0049] 0.5 parts of compound fermentation bacteria (sacchariculture yeast and lactic acid bacteria in a 1:1 weight ratio).

[0050] 2. Preparation steps:

[0051] Except for the fermentation temperature of 28℃, the fermentation time of 5 days, the drying temperature of 50℃, the vacuum degree of 0.06MPa, the stirring speed of 150r / min, and the stirring time of 30 minutes, the other steps are the same as in Example 1.

[0052] 3. Product testing: The prepared ointment has the required viscosity and toughness, is mild and non-irritating, and is suitable for people with sensitive skin.

[0053] 4. Instructions for use:

[0054] Method 1: Take 300-800g of ointment and spread it evenly on the affected joint (0.3cm thickness). Cover with sterile plastic film and heat with a far-infrared therapy lamp (40℃) for 45 minutes. After heating, place the ointment in a sealed iron can with a sealing ring and heat it in 80℃ hot water for 20 minutes for high-temperature sterilization. After drying, it can be reused.

[0055] Method 2: Take 6-20g of ointment, spread it evenly on a 4cm×6cm sterile non-woven fabric to make an ointment patch, apply it to the affected area and remove it after 4 hours; place the ointment in a sealed iron can with a sealing ring, heat it in 80-degree hot water for 20 minutes for high-temperature sterilization, and it can be reused after drying.

[0056] 5. Reusability: Method 1 can be reused 10-28 times, and Method 2 can be reused 3 times, with gentle and long-lasting conditioning effects.

[0057] Example 3

[0058] This embodiment provides a reusable traditional Chinese medicine external treatment ointment:

[0059] 1. Raw material preparation (by weight):

[0060] Core ingredients that are both food and medicine: 6 parts of black-striped snake, 6 parts of viper, 6 parts of safflower, 6 parts of old ginger, 6 parts of angelica dahurica, 6 parts of papaya, 6 parts of cinnamon, 6 parts of Sichuan pepper, 6 parts of peach kernel, 6 parts of angelica sinensis, 6 parts of chuanxiong rhizome, 6 parts of salvia miltiorrhiza, 6 parts of eucommia bark, 6 parts of cinnamon bark, 6 parts of achyranthes bidentata, 6 parts of coix seed, and 6 parts of poria cocos;

[0061] Additional ingredients: 15 parts honey, 8 parts glycerin, 12 parts maltose powder, 5 parts liquid paraffin, 6 parts sesame oil, 2 parts camphor;

[0062] One part of compound fermentation bacteria (sacchariculture yeast and lactic acid bacteria in a 1:1 weight ratio).

[0063] 2. Preparation steps:

[0064] Except for the fermentation temperature of 32℃, the fermentation time of 3 days, the drying temperature of 60℃, the vacuum degree of 0.08MPa, the stirring speed of 200r / min, and the stirring time of 20 minutes, the other steps are the same as in Example 1.

[0065] 3. Product testing: The prepared ointment has strong efficacy, good viscosity and toughness, and is not easily deformed or damaged.

[0066] 4. Instructions for use:

[0067] Method 1: Take 100-300g of ointment, spread it evenly on the affected area (0.5cm thickness), cover with sterile plastic film, and heat with a 45℃ hot compress for 60 minutes; after heating, place the ointment in a sealed iron can with a sealing ring, heat in 100℃ hot water for 20 minutes for high-temperature sterilization, and it can be reused after drying.

[0068] Method 2: Take 10g of ointment, spread it evenly on a 6cm×10cm sterile non-woven fabric to make an ointment patch, apply it to the affected area and remove it after 5 hours; place the ointment in a sealed iron can with a sealing ring, heat it in 100℃ hot water for 20 minutes for high-temperature sterilization, and it can be reused after drying.

[0069] 5. Reusability: Method 1 can be reused 10-28 times, and Method 2 can be reused 3 times, with gentle and long-lasting conditioning effects.

[0070] Test Example 1

[0071] A total of 120 patients with shoulder and neck pain, lower back and abdominal discomfort, and joint stiffness were selected and randomly divided into experimental groups 1-3 and a control group, with 30 patients in each group. Exclusion criteria: pregnant women, those with broken skin, those with allergies, and those with severe liver or kidney dysfunction.

[0072] Experimental Groups 1-2: The ointments of Examples 1-2 were used for treatment, and were used in accordance with Method 1 as described in the corresponding examples, for 2 consecutive weeks. After use, the ointments were disinfected at high temperature and dried as required before reuse (14 times).

[0073] Group 3 of the experiment: The ointment of Example 3 was used for treatment, and it was used in accordance with Method 2 described in Example 3 for 2 consecutive weeks. After use, the ointment was disinfected at high temperature and dried as required before reuse (it was replaced after 3 reuses).

[0074] Control group: Used commercially available Wantong Muscle and Bone Plaster according to the product instructions, changed every 24 hours, for 2 consecutive weeks.

[0075] Efficacy evaluation criteria: Significant improvement in physical signs (such as limited joint movement and muscle tension) and significant reduction or near disappearance of symptoms (such as pain, stiffness, and soreness) are considered markedly effective; improvement in physical signs and significant reduction or reduction of symptoms are considered effective; no change in physical signs and no improvement in symptoms are considered ineffective.

[0076] The results are shown in Table 1.

[0077] Table 1

[0078]

[0079] The results showed that the ointments provided in Examples 1-3 of this invention can effectively improve symptoms such as shoulder and neck pain, lower back and abdominal discomfort, and joint stiffness, demonstrating excellent clinical efficacy. No allergic reactions or other adverse reactions were observed in any of the patients in groups 1-3, while two patients in the control group experienced mild local itching. This indicates that the ointments of this invention have higher safety, and their reusable nature does not affect their therapeutic effect or safety, making them valuable for clinical promotion.

[0080] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A reusable traditional Chinese medicine external treatment ointment, characterized in that, Composed of core medicinal and edible ingredients and excipients, the core medicinal and edible ingredients, by weight, include 2-6 parts of black-striped snake, 2-6 parts of viper, 2-6 parts of safflower, 2-6 parts of old ginger, 2-6 parts of angelica dahurica, 2-6 parts of papaya, 2-6 parts of cinnamon, 2-6 parts of Sichuan pepper, 2-6 parts of peach kernel, 2-6 parts of angelica sinensis, 2-6 parts of chuanxiong rhizome, 2-6 parts of salvia miltiorrhiza, 2-6 parts of eucommia ulmoides, 2-6 parts of cinnamon bark, 2-6 parts of achyranthes bidentata, 2-6 parts of coix seed, and 2-6 parts of poria cocos; the excipients include 10-15 parts of honey, 5-8 parts of glycerin, 8-12 parts of maltose, 3-5 parts of liquid paraffin, 4-6 parts of edible oil, and 1-2 parts of camphor.

2. The reusable traditional Chinese medicine external treatment ointment according to claim 1, characterized in that, The edible oil is selected from one or more of soybean oil, peanut oil, and sesame oil.

3. The method for preparing the reusable traditional Chinese medicine external treatment ointment according to claim 1, characterized in that, Includes the following steps: (1) Clean the core medicinal and edible raw materials, remove impurities, dry them, and pulverize them into coarse powder of 20-40 mesh; (2) Add deionized water to the coarse powder from step (1) and then inoculate with compound fermentation bacteria. Ferment at a constant temperature of 28-32℃ for 3-5 days, stirring regularly during the process. (3) The fermented material obtained in step (2) is vacuum dried and then pulverized into 100-120 mesh fine powder to obtain fermented medicine powder; (4) Heat the honey to 45°C, remove the foam on the surface, and obtain melted honey; mix maltose powder and deionized water at a mass ratio of 1:0.9, heat and stir until completely dissolved, and obtain maltose solution; heat soybean oil to 65°C, keep it at a constant temperature for 10 minutes, and cool it to room temperature to obtain refined edible oil. (5) The fermented medicinal powder from step (3), the melted honey, maltose solution, glycerin, liquid paraffin, refined edible oil, and camphor from step (4) are mixed and stirred evenly in sequence, placed in a mold, kept at a constant temperature, cooled and demolded to obtain the reusable Chinese herbal external treatment ointment.

4. The preparation method according to claim 3, characterized in that, In step (2), the amount of deionized water added is 1.2-1.5 times the total weight of the core medicinal and edible raw materials. The compound fermentation bacteria are made by mixing brewing yeast and lactic acid bacteria in a mass ratio of 1:1, and the inoculation amount is 0.5-1% of the total weight of the core medicinal and edible raw materials.

5. The preparation method according to claim 3, characterized in that, In step (3), the vacuum drying conditions are 50-60℃ and vacuum degree 0.06-0.08MPa, and the material is dried until the moisture content is ≤8%.

6. The preparation method according to claim 3, characterized in that, In step (5), the stirring conditions are: 40-60℃, 150-200r / min, 20-30 minutes; the constant temperature standing conditions are: 30-35℃, 2.5-3 hours.

7. The preparation method according to claim 3, characterized in that, The method also includes: placing the used Chinese herbal external treatment ointment in a sealed iron can, soaking it in 80-100℃ hot water for 20-25 minutes for high-temperature sterilization, and then drying it for reuse.

8. The application of the reusable traditional Chinese medicine external treatment ointment as described in claim 1 in the preparation of medicines for treating discomfort in the shoulders, neck, waist, abdomen, and joints of the human body.

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